Form 8-K - Current report

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) December 2, 2024

Hoth Therapeutics, Inc.

(Exact name of registrant as specified in its charter)

Nevada		001-38803		82-1553794
(State or other jurisdiction of incorporation)		(Commission File Number)		(I. R. S. Employer Identification No.)

590 Madison Ave, 21^st Floor

New York, New York 10022

(Address of principal executive offices, including ZIP code)

(646) 756-2997

(Registrant’s telephone number, including area code)

Not Applicable

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common stock, $0.0001 par value		HOTH		The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 8.01 Other Events.

Hoth Therapeutics, Inc. (the “Company”) has prepared presentation materials (the “Presentation Materials”) that management intends to use from time to time on and after December 2, 2024, in presentations about the Company’s operations and performance. The Presentation Materials are filed as Exhibit 99.1 to this Current Report on Form 8-K.

The information contained in the Presentation Materials is summary information that should be considered within the context of the Company’s filings with the Securities and Exchange Commission and other public announcements that the Company may make by press release or otherwise from time to time. The Presentation Materials speak as of the date of this Current Report on Form 8-K. While the Company may elect to update the Presentation Materials in the future or reflect events and circumstances occurring or existing after the date of this Current Report on Form 8-K, the Company specifically disclaims any obligation to do so.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

Exhibit No.		Description
99.1		Presentation Materials
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: December 2, 2024	Hoth Therapeutics, Inc.

	/s/ Robb Knie
	Robb Knie
	Chief Executive Officer

Exhibit 99.1

December 2024 Innovating for Everyone Clinical - stage biopharmaceutical company focused on next generation therapeutics meeting unmet patient needs.

This presentation contains "forward - looking statements" within the meaning of the “safe - harbor” provisions of the Private Securities Litigation Reform Act of 1995 . These statements are identified by the use of words “could,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “may,” “continue,” “predict,” “potential” and similar expressions that are intended to identify forward - looking statements . Such statements involve known and unknown risks, uncertainties and other factors that could cause the actual results of Hoth Therapeutics, Inc . (“Hoth” or the “Company”) to differ materially from the results expressed or implied by such statements . These forward - looking statements are made on the basis of the current beliefs, expectations and assumptions of management, are not guarantees of performance and are subject to significant risks and uncertainty . These forward - looking statements should, therefore, be considered in light of various important factors, including those set forth in Hoth’s reports that it files from time to time with the Securities and Exchange Commission (the “Commission”) and which you should review, including those statements under “Item 1 A – Risk Factors” in Hoth’s Annual Report on Form 10 - K, as amended by its Quarterly Reports on Form 10 - Q and other reports that Hoth files with the Commission . Important factors that could cause actual results to differ materially from those described in forward - looking statements contained in this presentation include, but are not limited to : the adverse impact on economies around the world of the ongoing COVID - 19 pandemic ; changes to our anticipated sources of revenues ; competitive conditions ; difficulties in obtaining regulatory approvals for the Company’s product candidates ; changes in economic and political conditions ; the success of our research and development initiates ; and other factors . These forward - looking statements should not be relied upon as predictions of future events and Hoth cannot assure you that the events or circumstances discussed or reflected in these statements will be achieved or will occur . If such forward - looking statements prove to be inaccurate, the inaccuracy may be material . You should not regard these statements as representation or warranty by Hoth or any other person that we will achieve our objectives and plans in any specified timeframe, or at all . You are cautioned not to place undue reliance on these forward - looking statements, which speak only as of the date of this presentation . The Company disclaims any obligations to publicly update or release any revisions to the forward - looking information contained in this presentation, whether as a result of new information, future events or otherwise, after the date of this presentation or to reflect the occurrence of unanticipated events, except as required by law . Safe Harbor Statement : HOTH

At Hoth Therapeutics, we strive to develop innovative, impactful, and ground - breaking treatments with a goal to improve patient quality of life . We are a catalyst in early - stage pharmaceutical research and development, elevating promising drugs from the bench to pre - clinical and clinical testing . Utilizing a patient - centric approach, we collaborate and partner with a team of scientists, clinicians, and key opinion leaders to seek out and investigate medications that hold immense potential to create breakthroughs and diversify treatment options . Our mission is to bring value to both our shareholders and our patient populations . Our Mission : HOTH

Key Investment Highlights : HOTH Clinical Programs Robust Pre - Clinical Development Programs Targeting Unmet Medical Needs to Address Broad Market Experienced Management and Advisory Board

Pipeline : Multiple Shots on Goal : HOTH LAUNCH PHASE 3 PHASE 2 PHASE 1 IND - ENABLING PRECLINICAL PROOF OF CONCEPT DISEASE PRODUCT Mast - Cell Derived Cancers HT - KIT Oncology Traumatic Brain Injury/Ischemic Stroke Alzheimer’s Disease HT - TBI HT - ALZ Neurology Skin Toxicity associated with EGFR Inhibitors Atopic Dermatitis Acne HT - 001 BioLexa HT - 003D Dermatology Asthma Inflammatory Bowel Diseases HT - 004 HT - 003IBD Inflammatory

Primary Development : HOTH HT - 001 Topical Gel HT - KIT Injection HT - ALZ Oral Soluble Film BioLexa Lotion

HT - 001 : Value Proposition : HOTH Market Growth: EGFR Inhibitor Skin Toxicity market predicted to grow from $52M in 2018 to $391M by end of 2030* Mechanism of Action: 12 - week study conducted at GW suggests the topical application of HT - 001 significantly reduces erlotinib - induced cutaneous toxicities applied preventatively or proactively. It supports that HT - 001 may be used as a topical intervention to treat EGFR - inhibitor - induced cutaneous toxicity.** Addresses Unmet Need: No current approved product on th e market that specifically treats EGFR inhibitor cutaneous toxicities, which occur in up to 90% of patients undergoing EFGR inhibitor therapy.*** *EGFR Inhibitors - Induced Skin Disorders - Market Insights, Epidemiology, and Market Forecast - 2030 **https://ir.hoththerapeutics.com/ht - 001 ***https://jamanetwork.com/journals/jamadermatology/article - abstract/2767656

Recent & Upcoming Milestones : HT - 001 Topical Gel : HOTH Q1 2023 Initiated Phase 2a Clinical Trial in Open Label Cohort Q4 2024 All Clinical Sites Active and Enrolling in Open Label and Double - Blind Randomized Cohorts Initial Interim Open Label PK Cohort Data Q3 2025 Full Data Set for Open Label PK Cohort Q1 2025

IND - Opening Trial : CLEER - 001 Phase 2a Dose Ranging Study : HOTH A Randomized, Placebo - Controlled, Parallel Phase 2a Dose Ranging Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT - 001 for the Treatment of Cutaneous Toxicities Associated with EGFR Inhibitors 2 Parts – Parallel Study Design: • Part 1: Open - label treatment with HT - 001 2% for 6 weeks (PK cohort) • Part 2: Randomized double - blind treatment with HT - 001 0.5%, 1%, 2% or placebo Open - Label PK Cohort (6 weeks treatment + 2 weeks follow - up) N = 12 patients Part 1 Randomized, Double Blind Period (6 weeks treatment + 2 week treatment follow - up) N = 140 patients Part 2

HT - 001 505 (b)(2) Development Pathway : HOTH Current estimated dates; pending FDA meetings for phase 2b/phase 3 clinical studies NDA Submission IND Submission 2023 Phase 2a Clinical Study (US only) 2024 EOP2 FDA Meeting 2025 2026 Phase 2b Clinical Study (TBD) 2027 Phase 3 Clinical Study (s) Chronic Toxicology Studies Registration Batches Type C FDA Meeting In - Process 2028 2029 Pre - NDA Meeting

Erlotinib ( noVeh C) – Week 12 Erlotinib + Topical HT - 001 Initiated Week 1 – Week 12 Erlotinib + Topical HT - 001 Initiated Week 6 – Week 12 Proactive Topical HT - 001 Significantly Reduces EGFR Inhibitor - Induced Cutaneous Toxicity : HOTH Change Compared to Erlotinib Only Group: Hair Loss at 12 weeks Change Compared to Erlotinib Only Group: Facial Skin Lesions at 12 weeks Group 56.2% reduction in hair loss (p<0.001 vs Erl and p<0.001 vs control) 58.5% Reduction (p<001 vs Erl and p<0.01 vs control) Preventati ve Topical HT - 001 + Erlotinib 44.4% reduction in hair loss (p<0.001 vs Erl and p<0.001 vs control) 47.8% reduction (p<0.001 vs Erl and p<0.001 vs control) Proactive (week 6) Topical HT - 001 + Erlotinib

HT - KIT : Value Proposition : HOTH Market Growth: Global systemic mastocytosis treatment revenue is $128M and projected to grow at 5.8% CAGR through 2031* Mechanism of Action: HT - KIT is an antisense oligonucleotide that results in non - functional cKIT via mRNA frameshift.** Addresses Unmet Need: KIT D816V mutation found in >80% of adult systemic mastocytosis cases results in confirmational changes that make some tyrosine kinase inhibitor drugs ineffective.** cKIT is also implicated in gastrointestinal stromal tumors, acute myeloid leukemia, and other rare cancers *Global Systemic Mastocytosis Treatment Market Research Report, January 2022, Market.US **Snider et al., Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms , M olecular Therapy (2021), https://doi.org/10.1016/j.ymthe.2021.08.009

Recent & Upcoming Milestones : HT - KIT Injection : HOTH Q4 2023 Pre - IND Meeting with FDA and strategy confirmed Q1 2024 IND - enabling animal toxicology studies initiated Q1 2025 GLP animal studies and GMP API manufacturing initiation target Q4 2025 IND Submission target

HT - KIT Orphan Drug Development Pathway : HOTH Pivotal Clinical Studies (TBD) Current estimated dates; pending FDA meetings for clinical studies. Preclinical Dosing Studies Clinical Readiness: • Formulation Development • Toxicology studies • GMP Drug Manufacture • Clinical Protocol Development Pre - IND Meeting 2023 Type C FDA Meeting 2024 API Manufacturing 2025 Phase 1b Safety and Preliminary Efficacy Study in patients with mastocytosis IND Submission 2026 In - Process

Systemic delivery of human HT - KIT inhibits tumor growth in a humanized xenograft mast cell neoplasia model : HOTH Figures from Douglas B. Snider1, Greer K. Arthur1, Guido H. Falduto2, Ana Olivera2, Lauren C. Ehrhardt - Humbert1, Emmaline Smith 1, Cierra Smith1, Dean D. Metcalfe2 and Glenn Cruse1 (1Department of Molecular Biomedical Sciences, CVM, NC State University 2Laboratory of Allergic Di sea ses, NIAID, NIH). Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms. Poster presenta tio n at ASCO June 2021. HT - KIT

HT - KIT Reduces Liver Infiltration of Neoplastic Mast Cells in a Humanized Xenograft Model of Mast Cell Neoplasia : HOTH Figures from Douglas B. Snider1, Greer K. Arthur1, Guido H. Falduto2, Ana Olivera2, Lauren C. Ehrhardt - Humbert1, Emmaline Smith 1, Cierra Smith1, Dean D. Metcalfe2 and Glenn Cruse1 (1Department of Molecular Biomedical Sciences, CVM, NC State University 2Laboratory of Allergic Di sea ses, NIAID, NIH). Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms. Poster presenta tio n at ASCO June 2021.

HT - ALZ : Value Proposition : HOTH *https://www.acumenresearchandconsulting.com/alzheimers - disease - treatment - market **Martinez AN, Philipp MT. Substance P and Antagonists of the Neurokinin - 1 Receptor in Neuroinflammation Associated with Infecti ous and Neurodegenerative Diseases of the Central Nervous System. J Neurol Neuromedicine . 2016;1(2):29 - 36. doi:10.29245/2572.942x/2016/2.1020 ** Severini C, Petrella C, Calissano P. Substance P and Alzheimer's Disease: Emerging Novel Roles. Curr Alzheimer Res. 2016;13(9):964 - 72. doi : 10.2174/1567205013666160401114039. PMID: 27033058. Market Growth: The Global Alzheimer’s Disease Treatment Market is expected to grow at a CAGR of around 12.8% from 2020 to 2027 and reach the market value of over $5.2B by 2027.* Mechanism of Action: HT - ALZ targets the Substance P/Neurokinin - 1 Receptor pathway** in the brain, which has both negative (inflammatory) and positive (anti - amyloidogenic, memory, neuroprotective) roles in Alzheimer’s disease. Addresses Unmet Need: : There are currently no drugs approved that are considered disease modifying and demonstrate cognitive improvement. Preclinical data with HT - ALZ indicates HT - ALZ may provide reduced neuroinflammation and significant improvements in cognitive functions such as memory and learning.

Recent & Upcoming Milestones : HT - ALZ Oral Soluble Film : HOTH Q2 2024 HT - ALZ Formulation Work initiated Q3 2024 US Patent Office Awarded HT - ALZ Patent Q3 2024 Preclinical Studies completed at WashU 2025 Pre - IND Meeting Submission

HT - ALZ 505 (b)(2) Development Pathway : HOTH Continuation Of Clinical Studies (TBD) Current estimated dates; pending FDA meetings for clinical studies. Chronic Dose AD Mouse Model Studies 2023 Clinical Readiness: • Toxicology studies • GMP Drug Manufacture • Clinical Protocol Development • Site Selection and Activation Pre - IND Meeting 2024 Type C FDA Meeting 2025 2026 2027 Phase 1b PK/PD Clinical Study Formulation Development IND Submission In - Process

Biolexa : Value Proposition : HOTH Market Growth: Atopic dermatitis market predicted to grow from $6.4B in 2017 to $18.3B by end of 2027* Mechanism of Action: Novel mixture of two previously approved compounds targeting the underlying Staphylococcus aureus infection hypothesize to potentiate Atopic Dermatitis (AD) or eczema flares - First compound prevents biofilm formation, which protects the underlying infection, allowing the second, an antibiotic, to more effectively treat the underlying infection. Addresses Unmet Need: Non - corticosteroid treatment targeted for treatment of both pediatric and adult mild to moderate AD populations *Atopic Dermatitis Market – Global Industry Analysis, Size and Forecast, 2017 - 2027

Recent & Upcoming Milestones : BioLexa Lotion : HOTH 2021 Phase 1b Cohort 1 with healthy subjects completed Dec 2021 Phase 1b cohort in patients with mild to moderate atopic dermatitis initiated Sep 2022 Open Label dosing portion of Phase 1b Study is completed 2023 Data Readout from Phase 1b Clinical Study

BioLexa Phase 1b Clinical Study Design : HOTH A Randomised , Double - Blind, Vehicle Controlled, Sequential Group Study to Determine the Safety, Tolerability, Pharmacokinetics and Efficacy of Twice Daily Application of Topical BioLexa in Adult Healthy Subjects and Patients with Mild to Moderate Atopic Dermatitis

BioLexa : Proof - of - Concept Results : HOTH This study concluded that the combination of gentamicin and Ca - DTPA is more effective to reduce bacteria growth and inhibit the formation of biofilms than each compound individually. Miller School of Medicine, of the University of Miami and University of Cincinnati - Determination of the effects of a novel antimicrobial agent used in conjunction with Gentamicin on Staphylococcus aureus using a porcine model: preliminary evaluations Jose Valdes, Joel Gil, Andrew Herr, Andrew Harding and Stephen Davis Miller School of Medicine, of the University of Miami and University of Cincinnati - Determination of the effects of a novel antimicrobial agent used in conjunction with Gentamicin on Staphylococcus aureus using a porcine model: preliminary evaluations Jose Valdes, Joel Gil, Andrew Herr, Andrew Harding and Stephen Davis DT P A A lone Ge n ta m i c i n A lone Combination Reduced Bacteria Below LOQ

Preclinical Development : HOTH HT - 003 HT - 004 HT - TBI

HT - 003 : Value Proposition : HOTH Market Growth: The global acne treatment market size was valued at $5.46 Bn in 2019 & is projected to reach $7.19 Bn by 2027, with a CAGR of 4.6% during forecast period.* IBD Treatment market was valued at USD 15.87 billion by 2019, growing with 4.1% CAGR during the forecast period, 2020 - 2026** Mechanism of Action: Group of novel inhibitors of retinoic acid metabolism (collectively called RAMBAs), which prolong the presence of retinoic acid. Retinoids play key role in the regulation of immune cells and inflammation and are also important for differentiation of the skin. Addresses Unmet Need: Focuses on restoring immune system rather than inducing immune suppression (current therapies) *https://www.fortunebusinessinsights.com/acne - treatment - market - 103361 **https://www.marketwatch.com/press - release/inflammatory - bowel - disease - ibd - treatment - market - analysis - share - trends - size - forecast - from - 2020 --- 2030 - 2021 - 11 - 01?tesla=y

HT - 003D : Dermal Preclinical Study Results : HOTH TLR2 is one of the most critical genes for acne pathophysiology Data shows that HT - 003 significantly downregulates TLR2 expression after challenge with PGN (TLR2 agonist) in an in vitro human keratinocyte model

HT - 003IBD : Preclinical Study Results Ulcerative Colitis Ex Vivo Tissue (n = 2 donors) : HOTH HT - 003 molecules reduce inflammatory cytokines associated with IBD and promotes intestinal homeostasis U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 I L - 1 7 a l p h a r e l e a s e ( % C o n t r o l ) U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 200 250 I L - 2 2 r e l e a s e ( % C o n t r o l ) U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 I L - 2 2 r e l e a s e ( % C o n t r o l ) U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 200 I L - 1 7 a l p h a r e l e a s e ( % C o n t r o l ) BIRB796 = positive therapeutic control | CFW = HT - 003 molecules 1 – 4 unique entities

HT - 003IBD : Preclinical Study Results Crohn’s Ex Vivo Tissue (n = 1 donor) : HOTH HT - 003 molecules reduce inflammatory cytokines associated with IBD and promotes intestinal homeostasis CFW = HT - 003 molecules 1 – 4 unique entities | BIRB796 = positive therapeutic control U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 I L - 1 7 a l p h a r e l e a s e ( % C o n t r o l ) U n s t i m u l a t e d c o n t r o l V e h i c l e B I R B 7 9 6 C F W 0 0 1 / 0 1 C F W 0 0 1 / 0 2 C F W 0 0 1 / 0 3 C F W 0 0 1 / 0 4 0 50 100 150 I L - 2 2 r e l e a s e ( % C o n t r o l )

HT - 004 : Value Proposition : HOTH Market Growth: The global asthma therapeutics market reached a value of $17.6B in 2020. The market is expected to reach a value of $19.13B by 2026, expanding at a CAGR of 1.60% during 2021 - 2026.* Mechanism of Action: Target IgE receptor trafficking to prevent downstream inflammatory pathways Addresses Unmet Need: New class of drug for maintenance treatment of asthma with potential for a better safety profile *Asthma Therapeutics Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2021 - 2026, imarc

HT - 004 : Asthma & Allergic Inflammation : HOTH B a s e l i n e V e h i c l e C o n t r o l O l i g o C o n t r o l B e t a O l i g o 0 1 2 3 4 5 B r o n c h i o l a r i n f l a m m a t i o n s c o r e **** **** n.s. • Peribronchiolar Inflammation was reduced by inhalation of HT - 004 that targets FcER1 - beta alternative exon splicing. • Ovalbumin inhalation induced airway - centric recruitment of inflammatory cells predominated by eosinophils admixed with lymphocytes, macrophages, and fewer mast cells. • Inflammatory cell recruitment was minimal in lungs of mice lacking the ovalbumin - induced allergic airway disease and administered only PBS vehicle control. • Inflammatory cell recruitment was moderate to marked resulting in expansion of peribronchiolar connective tissues by several cells thick in some areas for mice in control treatment groups with ovalbumin - induced allergic airway disease (vehicle control and oligo (non - target) control. • Despite ovalbumin - induced allergic airway induction, lungs from mice receiving inhalation of HT - 004 had reduced inflammatory cell recruitment around bronchioles.

HT - TBI : Value Proposition : HOTH Market Growth: The global stroke management market size was valued at $31.7B in 2020, and is projected to reach $67.7B by 2030, registering a CAGR of 7.8% from 2021 to 2030.* The traumatic brain injuries treatment market to account $201.1B by 2029 by growing at a CAGR of 5.00% in the forecast period of 2022 - 2029.** Mechanism of Action: Target neurokinin - 1/substance P to prevent downstream inflammatory pathways leading to secondary brain injury (edema, inflammation) Addresses Unmet Need: : There is insufficient clinical evidence to support the use of the current hyperosmotic therapy methods ( eg , mannitol) for lowering intracranial pressure per the Guidelines for the Management of Severe Traumatic Brain Injury; hyperosmotic therapy can also be associated with risk to patient morbidity and mortality.*** *Stroke Management Market Statistics 2030, Allied Market Research **Global Traumatic Brain Injuries Treatment Market – Industry Trends and Forecast to 2029, Data Bridge Market Research ***Guidelines for the Management of Severe Traumatic Brain Injury 4th Edition, Brain Trauma Foundation

Investment Highlights : HOTH Programs in Clinical Stage of Development Diverse and Robust Pipeline of Pre - Clinical Candidates Clean Financials Experienced Management, Board and Scientific Advisors • Addressing multi - billion - dollar unmet market opportunities across indications • HT - 001 – no approved product/competitor currently on the market, clinical trial currently enrolling • HT - KIT – Pre - IND Meeting with FDA successful and IND - enabling tox studies and development planned for 2025 • Offers strong intellectual property portfolio, including exclusive licenses to patents and trademarks • Multiple shots on goal with diversified portfolio and market • Multiple assets have platform technology possibilities • 7.7 million shares outstanding (as of November 29, 2024) • Cash on hand is sufficient to take company through the clinical and pre - clinical programs currently in development • Experienced management team, board of directors and scientific advisors with proven financial, capital markets and drug development experience

Thank You. : HOTH : HOTH Contact Information Investor Relations: Hoth Therapeutics, Inc. investorrelations@hoththerapeutics.com

Cover	Dec. 02, 2024
Cover [Abstract]
Document Type	8-K
Amendment Flag	false
Document Period End Date	Dec. 02, 2024
Entity File Number	001-38803
Entity Registrant Name	Hoth Therapeutics, Inc.
Entity Central Index Key	0001711786
Entity Tax Identification Number	82-1553794
Entity Incorporation, State or Country Code	NV
Entity Address, Address Line One	590 Madison Ave
Entity Address, Address Line Two	21st Floor
Entity Address, City or Town	New York
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10022
City Area Code	646
Local Phone Number	756-2997
Written Communications	false
Soliciting Material	false
Pre-commencement Tender Offer	false
Pre-commencement Issuer Tender Offer	false
Title of 12(b) Security	Common stock, $0.0001 par value
Trading Symbol	HOTH
Security Exchange Name	NASDAQ
Entity Emerging Growth Company	true
Elected Not To Use the Extended Transition Period	false