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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
August 7, 2023
CARA THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Delaware |
|
001-36279 |
|
75-3175693 |
(State or other jurisdiction
of incorporation) |
|
(Commission
File Number) |
|
(IRS Employer
Identification No.) |
|
|
|
|
|
4 Stamford Plaza
107 Elm Street, 9th Floor
Stamford, Connecticut |
|
|
|
06902 |
(Address of principal executive offices) |
|
|
|
(Zip Code) |
|
|
|
|
|
Registrant's telephone number, including area code (203) 406-3700 |
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):
¨ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
Title
of each class |
Trading
Symbol |
Name
of each exchange on which registered |
Common Stock, par value $0.001 per share |
CARA |
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ¨
If an emerging growth company, indicate by
check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨.
Item 2.02. |
Results of Operations and Financial Condition. |
On August 7, 2023, Cara Therapeutics, Inc. (the “Company”)
issued a press release announcing its financial results for the second quarter ended June 30, 2023. A copy of the press release
is being furnished to the Securities and Exchange Commission as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated
by reference to this Item 2.02.
The information furnished pursuant to this Item 2.02, including Exhibit 99.1,
shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange
Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any of
the Company’s filings with the Securities and Exchange Commission under the Exchange Act or the Securities Act of 1933, as amended,
whether made before or after the date hereof, regardless of any general incorporation language in such a filing.
Item 9.01. |
Financial Statements and Exhibits. |
(d) Exhibits
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|
CARA THERAPEUTICS, INC. |
|
|
|
By: |
/s/
RYAN MAYNARD |
|
|
Ryan Maynard |
|
|
Chief Financial Officer |
|
|
(Principal Financial and Accounting Officer) |
Date: August 7, 2023
Exhibit 99.1
Cara Therapeutics Reports Second Quarter 2023
Financial Results
– 2Q23 total revenue of $6.9M including
collaborative revenue of $5.4M from the Company’s share of profit of KORSUVA® (difelikefalin) injection –
– Demand for KORSUVA injection accelerating
with 46% increase in vial orders quarter to quarter –
– 2024 ESRD PPS proposed rule suggests
additional funding for TDAPA-designated products in existing functional category; final rule expected in 4Q23 –
– Three late-stage oral difelikefalin
clinical programs tracking to plan; Internal readout of Part A of KIND 1 atopic dermatitis trial expected in 4Q23 –
– Conference call today at 4:30 p.m. EDT
–
STAMFORD, Conn., August 7, 2023 – Cara
Therapeutics, Inc. (Nasdaq: CARA), a commercial-stage biopharmaceutical company leading a new treatment paradigm to improve
the lives of patients suffering from pruritus, today announced financial results and operational highlights for the second quarter ended
June 30, 2023.
“In the second quarter of 2023, the commercialization
of KORSUVA® (difelikefalin) injection in the U.S. and Kapruvia® in countries around the world continued
to make meaningful progress. We believe the increased vial shipments and reorder rates in the U.S., as well as the positive feedback from
providers and patients globally, confirm the significant need for an anti-pruritic treatment for chronic kidney disease (CKD) patients,”
said Christopher Posner, President and Chief Executive Officer of Cara Therapeutics. “In June, CMS issued the CY2024 ESRD PPS proposed
rule, providing clarity around the reimbursement of KORSUVA injection post its TDAPA period. While we were pleased that CMS included additional
funding outside the bundle rate in the proposed rule, we will continue to work with CMS on refining the reimbursement methodology ahead
of the release of the final rule, which is expected in the fourth quarter of 2023.”
Mr. Posner continued, “On the development
front, we are pleased with the progress of our late-stage oral difelikefalin programs for pruritus associated with atopic dermatitis (AD),
advanced CKD and notalgia paresthetica (NP). All three trials are enrolling patients and the internal readout from Part A of our
KIND Phase 3 program in AD is expected in the fourth quarter of 2023. As the key driver of our long-term value, we are focused on advancing
the development of oral difelikefalin in our nephrology and medical dermatology franchises and remain steadfast in our commitment to establishing
Cara Therapeutics as the leader in the treatment of chronic pruritus.”
2Q23 and Recent Highlights
| · | England’s National Institute for Health
and Care Excellence (NICE) recommended Kapruvia® for the treatment of moderate-to-severe chronic kidney disease-associated
pruritus (CKD-aP) in adult patients on hemodialysis |
| · | Enrollment continued in the KIND Phase 3 program
in AD with the internal readout from Part A expected in 4Q23 and final topline results for the program expected in 1H25 |
| · | Enrollment continued in the KICK Phase 3 program
in advanced CKD with topline results expected in 2H24 |
| · | KOURAGE Phase 2/3 program of oral difelikefalin
for the treatment of moderate-to-severe pruritus in patients with NP is ongoing; internal readout from Part A is expected in 2H24
with final topline results for the program expected in 1H26 |
KORSUVA Injection Launch Update: 2Q23
United States
In the second quarter of 2023, KORSUVA injection
generated net sales of $11.4 million and the Company recorded collaborative revenue of $5.4 million, which represented the Company’s
share of the profit from sales of KORSUVA injection.
Wholesalers shipped 66,852 vials to dialysis centers,
the majority of which were Fresenius clinics, during the second quarter of 2023. Vial orders increased 46% quarter to quarter, indicating
an acceleration in patient demand.
In June 2023, the Centers for Medicare &
Medicaid Services (CMS) issued a proposed rule for the End Stage Renal Disease Prospective Payment System (ESRD PPS) for calendar
year 2024, which addresses the reimbursement of KORSUVA injection after its Transitional Drug Add-On Payment Adjustment (TDAPA) period.
The final rule is expected in the fourth quarter of 2023.
International
In the second quarter of 2023, Kapruvia generated
$1.2 million in net sales and the Company recorded $123,000 in royalty revenue associated with Kapruvia sales in Europe.
Seven EU countries have launched Kapruvia to date,
and the Company expects additional launches to commence over the coming months. In May 2023, England’s NICE recommended Kapruvia
for the treatment of moderate-to-severe CKD-aP in adult patients on hemodialysis.
The Company continues to expect its licensing
partner Maruishi Pharmaceutical Co., Ltd. to receive a regulatory decision from the Pharmaceuticals and Medical Devices Agency (PMDA)
in Japan in the second half of 2023.
Upcoming Meeting Activities
The Company expects to present at the following
upcoming investor conferences:
| · | Canaccord Genuity 43rd Annual Growth
Conference, August 7-10 |
| · | Stifel Biotech Summer Summit, August 14-15 |
| · | H.C. Wainwright Global Investment Conference,
September 11-13 |
Second Quarter 2023 Financial Results
Cash, cash equivalents and marketable securities
at June 30, 2023 totaled $101.7 million compared to $156.7 million at December 31, 2022. The decrease in the balance primarily
resulted from $55.1 million of cash used in operating activities.
For the second quarter of 2023, net loss was $31.5
million, or $(0.58) per basic and diluted share, compared to net loss of $4.2 million, or $(0.08) per basic and diluted share, for the
same period in 2022.
Revenues: Total revenue was $6.9 million
and $23.0 million for the three months ended June 30, 2023 and 2022, respectively. Revenue primarily consisted of:
| · | $5.4
million and $8.0 million of collaborative revenue related to our share of the profit from
CSL Vifor’s sales of KORSUVA injection to third parties during the three months ended
June 30, 2023 and 2022, respectively; |
| · | $1.4
million of commercial supply revenue related to sales of KORSUVA injection to CSL Vifor during
the three months ended June 30, 2023. There was no commercial supply revenue during
the three months ended June 30, 2022; |
| · | Approximately
$123,000 of royalty revenue related to our royalties on the net sales of Kapruvia in Europe
during the three months ended June 30, 2023. There was no royalty revenue during the
three months ended June 30, 2022; and |
| · | There
was no license and milestone revenue during the three months ended June 30, 2023. We
recorded $15.0 million in milestone revenue related to the approval of Kapruvia by the European
Commission in April 2022 during the three months ended June 30, 2022. |
Cost of Goods Sold: Cost of goods
sold was $1.4 million during the three months ended June 30, 2023, related to commercial supply revenue for KORSUVA injection
sales to CSL Vifor. There was no associated cost of goods sold during the three months ended June 30, 2022 as there was no
commercial supply revenue from CSL Vifor.
Research and Development (R&D) Expenses:
R&D expenses were $30.3 million for the three months ended June 30, 2023 compared to $19.9 million in the same period of
2022. The higher R&D expenses in 2023 were primarily due to increases in clinical trial costs related to our three late-stage development
programs partially offset by a decrease in stock-based compensation expense.
General and Administrative (G&A) Expenses:
G&A expenses were essentially flat at $7.5 million for the three months ended June 30, 2023 compared to $7.6 million in the same
period of 2022.
Other Income, net: Other income, net was
approximately $861,000 for the three months ended June 30, 2023 compared to approximately $266,000 in the same period of 2022. The
increase in other income, net was primarily due to an increase in interest income resulting from a higher yield on our portfolio of investments
during the three months ended June 30, 2023.
Financial Guidance
We expect that our current unrestricted cash and
cash equivalents and available-for-sale marketable securities, including collaborative revenue from our share of the profit from KORSUVA
injection, will be sufficient to fund our currently anticipated operating plan for at least the next 12 months.
About Cara Therapeutics
Cara Therapeutics is
a commercial-stage biopharmaceutical company leading a new treatment paradigm to improve the lives of patients suffering from pruritus.
The Company’s KORSUVA® (difelikefalin) injection is the first and only FDA-approved treatment for moderate-to-severe pruritus
associated with chronic kidney disease in adults undergoing hemodialysis. The Company is developing an oral formulation of difelikefalin
and has Phase 3 programs ongoing for the treatment of pruritus in patients with advanced chronic kidney disease and atopic dermatitis.
In addition, the Company has initiated a Phase 2/3 program of oral difelikefalin for the treatment of moderate-to-severe pruritus in
patients with notalgia paresthetica. For more information, visit www.CaraTherapeutics.com and follow the company on Twitter,
LinkedIn and Instagram.
Forward-looking Statements
Statements contained in this press release regarding matters that are
not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of
1995. Examples of these forward-looking statements include statements concerning the Company’s and its partners’ ongoing commercialization
of and ability to successfully commercialize KORSUVA injection and Kapruvia, future revenue and profit share from sales of KORSUVA and
Kapruvia, planned future regulatory submissions and potential future regulatory approvals, potential for post-TDAPA reimbursement of KORSUVA
and timing of final rules related thereto, future product launches, the performance of the Company’s commercial partners, including
CSL Vifor, expected timing of the initiation, enrollment and data readouts from the Company’s planned and ongoing clinical trials,
the potential results of ongoing clinical trials, timing of future regulatory and development milestones for the Company’s product
candidates, the potential for the Company’s product candidates to be alternatives in the therapeutic areas investigated and the
potential for oral difelikefalin to address additional pruritic indications, the size and growth of the potential markets for pruritus
management, the Company’s participation in certain conferences and the Company’s expected cash reach. Because such statements
are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements.
These risks and uncertainties include the risks inherent in the launch of new products, including that our commercial partners, including
CSL Vifor, may not perform as expected, risks inherent in the clinical and regulatory development of pharmaceutical products, and the
risks described more fully in Cara Therapeutics’ filings with the Securities and Exchange Commission, including the “Risk
Factors” section of the Company’s Annual Report on Form 10-K for the year ending December 31, 2022 and its other
documents subsequently filed with or furnished to the Securities and Exchange Commission, including its Form 10-Q for the quarter
ended March 31, 2023. All forward-looking statements contained in this press release speak only as of the date on which they were
made. Cara Therapeutics undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after
the date on which they were made, except as required by law.
Financial tables follow
CARA THERAPEUTICS, INC. |
CONDENSED BALANCE SHEETS |
(in thousands) |
(unaudited) |
| |
| | |
| |
| |
June 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
Assets | |
| | | |
| | |
Current assets: | |
| | | |
| | |
Cash and cash equivalents | |
$ | 58,249 | | |
$ | 63,741 | |
Marketable securities | |
| 36,442 | | |
| 81,658 | |
Accounts receivable, net - related party | |
| 10,124 | | |
| 3,260 | |
Inventory, net | |
| 3,420 | | |
| 2,383 | |
Income tax receivable | |
| 697 | | |
| 697 | |
Other receivables | |
| 420 | | |
| 496 | |
Prepaid expenses | |
| 14,976 | | |
| 16,267 | |
Restricted cash | |
| 408 | | |
| 408 | |
Total current assets | |
| 124,736 | | |
| 168,910 | |
Operating lease right-of-use assets | |
| 792 | | |
| 1,551 | |
Marketable securities, non-current | |
| 7,053 | | |
| 11,350 | |
Property and equipment, net | |
| 308 | | |
| 426 | |
Restricted cash, non-current | |
| 1,500 | | |
| - | |
Total assets | |
$ | 134,389 | | |
$ | 182,237 | |
| |
| | | |
| | |
Liabilities and stockholders’ equity | |
| | | |
| | |
Current liabilities: | |
| | | |
| | |
Accounts payable and accrued expenses | |
$ | 24,475 | | |
$ | 21,540 | |
Operating lease liabilities, current | |
| 982 | | |
| 1,918 | |
Total current liabilities | |
| 25,457 | | |
| 23,458 | |
| |
| | | |
| | |
Commitments and contingencies | |
| - | | |
| - | |
| |
| | | |
| | |
Stockholders’ equity: | |
| | | |
| | |
Preferred stock | |
| - | | |
| - | |
Common stock | |
| 54 | | |
| 53 | |
Additional paid-in capital | |
| 733,984 | | |
| 726,630 | |
Accumulated deficit | |
| (624,376 | ) | |
| (566,232 | ) |
Accumulated other comprehensive loss | |
| (730 | ) | |
| (1,672 | ) |
Total stockholders’ equity | |
| 108,932 | | |
| 158,779 | |
Total liabilities and stockholders’ equity | |
$ | 134,389 | | |
$ | 182,237 | |
CARA THERAPEUTICS, INC. |
CONDENSED STATEMENTS OF OPERATIONS |
(amounts in thousands, except share and per share data) |
(unaudited) |
|
| |
Three Months Ended June 30, | | |
Six Months Ended June 30, | |
| |
2023 | | |
2022 | | |
2023 | | |
2022 | |
Revenue: | |
| | | |
| | | |
| | | |
| | |
Collaborative revenue | |
$ | 5,410 | | |
$ | 8,003 | | |
$ | 8,160 | | |
$ | 8,003 | |
Commercial supply revenue | |
| 1,400 | | |
| - | | |
| 4,591 | | |
| 4,790 | |
Royalty revenue | |
| 123 | | |
| - | | |
| 248 | | |
| - | |
License and milestone fees | |
| - | | |
| 15,000 | | |
| - | | |
| 15,000 | |
Clinical compound revenue | |
| - | | |
| - | | |
| 99 | | |
| - | |
Total revenue | |
| 6,933 | | |
| 23,003 | | |
| 13,098 | | |
| 27,793 | |
| |
| | | |
| | | |
| | | |
| | |
Operating expenses: | |
| | | |
| | | |
| | | |
| | |
Cost of goods sold | |
| 1,418 | | |
| - | | |
| 4,008 | | |
| 2,081 | |
Research and development | |
| 30,310 | | |
| 19,905 | | |
| 54,644 | | |
| 41,178 | |
General and administrative | |
| 7,545 | | |
| 7,570 | | |
| 14,436 | | |
| 16,917 | |
Total operating expenses | |
| 39,273 | | |
| 27,475 | | |
| 73,088 | | |
| 60,176 | |
Operating loss | |
| (32,340 | ) | |
| (4,472 | ) | |
| (59,990 | ) | |
| (32,383 | ) |
| |
| | | |
| | | |
| | | |
| | |
Other income, net | |
| 861 | | |
| 266 | | |
| 1,846 | | |
| 428 | |
Net loss | |
| (31,479 | ) | |
| (4,206 | ) | |
| (58,144 | ) | |
| (31,955 | ) |
| |
| | | |
| | | |
| | | |
| | |
Net loss per share: | |
| | | |
| | | |
| | | |
| | |
Basic and Diluted | |
$ | (0.58 | ) | |
$ | (0.08 | ) | |
$ | (1.08 | ) | |
$ | (0.60 | ) |
| |
| | | |
| | | |
| | | |
| | |
Weighted average shares: | |
| | | |
| | | |
| | | |
| | |
Basic and Diluted | |
| 54,002,988 | | |
| 53,614,668 | | |
| 53,937,875 | | |
| 53,561,161 | |
MEDIA CONTACT:
Annie Spinetta
6 Degrees
973-768-2170
aspinetta@6degreespr.com
INVESTOR CONTACT:
Iris Francesconi, Ph.D.
Cara Therapeutics
203-406-3700
investor@caratherapeutics.com
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Cara Therapeutics (NASDAQ:CARA)
過去 株価チャート
から 4 2024 まで 5 2024
Cara Therapeutics (NASDAQ:CARA)
過去 株価チャート
から 5 2023 まで 5 2024