The data were published at the annual world congress of the
European Society of Medical Oncology (ESMO), which this year takes
place in Barcelona and brings
together the leading international companies in the sector,
presenting the most innovative developments in cancer
research.
BARCELONA, Spain, Sept. 17, 2024 /PRNewswire/ -- Kience has
presented the results of the first validation study of its
innovative non-invasive test based on a blood and urine sample.
This test, especially aimed at people aged 40 and over, promises to
provide early and accurate screening for up to 42 different types
of solid tumors and 5 hematological malignancies (even in the early
stages), before the first symptoms and signs appear, precisely when
treatment is most likely to be successful.
The test is claimed to be much less invasive, more economical
and more guaranteed to offer fewer false positives than other tests
currently on the market to detect different types of cancer, thanks
to being based on a machine learning algorithm of its own creation
that includes, among other innovations, the Barcelona Criteria,
four criteria established by Dr. Rafael Molina† together with other
members of the Spanish Society of Clinical Chemistry (SEQCML) in
1994, on the correct interpretation of tumor markers.
For the development of the algorithm, Kience initially used a
sample size (n) of 192,090 patients, which is the sample resulting
from the agglutination of more than 1,600 previous studies (some of
them acquired through different technology transfer contracts with
the developing medical centers). It was then processed using
complex mathematical functions, mainly serial and parallel
approximations, to increase specificity and sensitivity,
respectively. From here, a sample of 314 patients (166 in the final
sample) was recruited to validate the efficacy of the test. The
blood and urine samples of these patients were analyzed by
Laboratorio Echevarne (Sant Cugat del Vallès, Barcelona), and subsequently processed with
the algorithm for the evaluation of their results.
Without the application of the Barcelona Criteria, the algorithm
achieved a sensitivity of 100% but a specificity of only 67%, with
a positive predictive value (PPV) of 21%. In contrast, when
applying the Barcelona Criteria, the specificity was 100% and the
PPV improved considerably, also reaching 100%. Even so, it is
important to note that these results were obtained with a final
sample of 166 patients (148 patients were excluded from the trial
because they did not meet any of the trial criteria). Nevertheless,
the results themselves demonstrate how important it is to include
the Barcelona Criteria in any test that makes use of tumor markers
(such as cancer screening tests), in order to avoid false positives
and, consequently, overdiagnosis errors.
The company has launched a new international clinical trial with
26,000 patients to further improve the accuracy of the algorithm in
the general population. This new trial will run from September 2024 to December
2026.
About Kience Inc.
Kience is a biotechnology company based in Delaware, U.S., resulting from the integration
of the Catalan companies Cloud Health Solutions, Bioprognos and
Blueberry Diagnostics, focused on the development of revolutionary
tests for the prevention, screening and diagnostic confirmation of
cancer.
More information: https://www.kience.com
Chief Communications Officer
Ángel Plana
+34 659 61 51 84
383390@email4pr.com
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SOURCE Kience Inc.