DNAPrint Selects Proteos to Manufacture PT-401 for Pre-Clinical Evaluation
2005年6月14日 - 11:44PM
PRニュース・ワイアー (英語)
DNAPrint Selects Proteos to Manufacture PT-401 for Pre-Clinical
Evaluation SARASOTA, Fla., June 14 /PRNewswire-FirstCall/ --
DNAPrint genomics, Inc. (OTC:DNAP) (BULLETIN BOARD: DNAP) (the
"Company") today announced that it has selected Proteos, Inc. to
manufacture the first batch of its new therapeutic candidate PT-401
(Super EPO dimer) for pre-clinical testing. "Proteos has 20 years
of experience in protein and peptide chemistry and has proven its
ability as a Contract Research Organization (CRO) dealing with
biologically complex therapeutics," stated DNAPrint Chairman and
Chief Medical Officer Hector Gomez, M.D., Ph.D. "The selection of
Proteos is the culmination of a competitive bidding process
solicited by DNAPrint management. In addition, Proteos' staff has
previously worked with erythropoietin (EPO), the simpler, monomer
form of the drug that major pharmaceutical companies currently have
on the market." DNAPrint announced in April that it has acquired an
exclusive worldwide license from Harvard Medical School's Beth
Israel Deaconess Medical Center (BIDMC) to develop a new, more
potent and longer acting form of the anemia drug erythropoietin.
DNAPrint is working on the project with Dr. Arthur J. Sytkowski,
Director for the Laboratory for Cell and Molecular Biology,
Division of Hematology and Oncology at Beth Israel Deaconess. The
PT-401 to be manufactured by Proteos will be used to generate
pre-clinical data required for an Investigational New Drug (IND)
application as required by the U.S. Food and Drug Administration.
"We are now beginning the clinical development process and today's
announcement is a major step for DNAPrint toward compiling the data
for its first IND application," stated President and Chief
Executive Officer Richard Gabriel. "Dr. Sytkowski, who has worked
his entire career on Erythropoietin and similar molecules, and Dr.
Gomez selected Proteos for its technical skills and background and
will monitor the data collection very closely." DNAPrint also
announced that it has agreed to a six-month contract with Dr.
Sytkowski to provide continued support for the completion of the
PT-401 clinical research program. "Dr. Sytkowski holds eight
patents covering this technology and is the author of a book on the
subject, 'Erythropoietin, Blood, Brain and Beyond.' He brings a
knowledge base to the development of our licensed product, and his
agreement is structured to give him appropriate incentives to help
move the product through clinical development," Dr. Gomez stated.
About Proteos Proteos, Inc. ( http://www.proteos.net/ ) is a
provider of high quality proteins and peptides for enabling and
facilitating drug discovery. The Proteos Process includes target
identification, expression using various cell lines, purification
and production of proteins. Unique protein services include
Expression in baculovirus, mammalian cells, and E coli, Refolding
of proteins from inclusion bodies, Purification, and Assay
Development. Peptide services include Design and Modification, and
Antigen Design, Production and Purification. Proteos, based in
Kalamazoo, Mich., was founded by eight scientists following the
August 2002 acquisition of Pharmacia by Pfizer, Inc. About DNAPrint
genomics, Inc. DNAPrint genomics, Inc. ( http://www.dnaprint.com/ )
is a developer of genomics-based products and services focused on
drug development, pharmacogenomic diagnostic tests, forensics
technology and consumer genetic tests. The Company's first
theranostic product (drug/test combination) is PT-401, a "Super
EPO" (erythropoietin) dimer protein drug for treatment of anemia in
renal dialysis patients (end stage renal disease). Currently in
pre-clinical development, PT-401 will be targeted to patients with
a genetic profile indicating their propensity to have the best
clinical response. Forward-Looking Statements All statements in
this press release that are not historical are forward- looking
statements. Such statements are subject to risks and uncertainties
that could cause actual results to differ materially from those
projected, including, but not limited to, uncertainties relating to
technologies, product development, manufacturing, market
acceptance, cost and pricing of DNAPrint's products, dependence on
collaborations and partners, regulatory approvals, competition,
intellectual property of others, and patent protection and
litigation. DNAPrint genomics, Inc. expressly disclaims any
obligation or undertaking to release publicly any updates or
revisions to any forward- looking statements contained herein to
reflect any change in DNAPrint's expectations with regard thereto
or any change in events, conditions, or circumstances on which any
such statements are based. Company Contact: Richard Gabriel
President and CEO 941-366-3400 -or- Ron Stabiner The Wall Street
Group, Inc. 212-888-4848 DATASOURCE: DNAPrint genomics, Inc.
CONTACT: Richard Gabriel, President and CEO of DNAPrint genomics,
+1-941-366-3400, or Ron Stabiner of The Wall Street Group, Inc.,
+1-212-888-4848, for DNAPrint Web site: http://www.dnaprint.com/
http://www.proteos.net/
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