- Termination of Registration of a Class of Security under Section 12(g) (15-12G)

Rule 12g-4(a)(1)

Rule 12g-4(a)(2)

Rule 12h-3(b)(1)(i)

Rule 12h-3(b)(1)(ii)

Rule 15d-6

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 15

CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 .

Commission File Number 000-50405

Acusphere, Inc.

(Exact name of registrant as specified in its charter)

500 Arsenal Street

Watertown, MA 02472

(617) 648-8800

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Common Stock, $.01 Par Value

(Title of each class of securities covered by this Form)

None

(Titles of all other classes of securities for which a duty to file reports under section 13(a) or 15(d) remains)

Please place an X in the box(es) to designate the appropriate rule provision(s) relied upon to terminate or suspend the duty to file reports:

Approximate number of holders of record as of the certification or notice date: 224

Pursuant to the requirements of the Securities Exchange Act of 1934, Acusphere, Inc. has caused this certification/notice to be signed on its behalf by the undersigned duly authorized person.