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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
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☒ |
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended June 30, 2024
OR
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☐ |
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from to
Commission File Number: 001-39676
INHIBIKASE THERAPEUTICS, INC.
(Exact Name of Registrant as Specified in its Charter)
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Delaware |
26-3407249 |
( State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
3350 Riverwood Parkway SE, Suite 1900 Atlanta, GA |
30339 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including area code: (678) 392-3419
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common Stock, $0.001 par value |
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IKT |
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The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer |
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☐ |
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Accelerated filer |
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☐ |
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Non-accelerated filer |
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☒ |
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Smaller reporting company |
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☒ |
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Emerging growth company |
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☒ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of August 1, 2024, the registrant had 7,464,070 shares of common stock, $0.001 par value per share, outstanding.
Table of Contents
PART I—FINANCIAL INFORMATION
Item 1. Condensed Consolidated Financial Statements (Unaudited).
Inhibikase Therapeutics, Inc.
Condensed Consolidated Balance Sheets
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June 30, 2024 |
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December 31, 2023 |
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(unaudited) |
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(Note 3) |
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Assets |
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Current assets: |
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Cash and cash equivalents |
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$ |
3,086,455 |
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$ |
9,165,179 |
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Marketable securities |
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4,853,559 |
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4,086,873 |
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Prepaid research and development |
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306,300 |
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219,817 |
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Prepaid expenses and other current assets |
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356,487 |
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739,179 |
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Total current assets |
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8,602,801 |
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14,211,048 |
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Equipment and improvements, net |
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60,235 |
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73,372 |
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Right-of-use asset |
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163,762 |
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222,227 |
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Total assets |
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$ |
8,826,798 |
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$ |
14,506,647 |
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Liabilities and stockholders’ equity |
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Current liabilities: |
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Accounts payable |
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$ |
1,340,538 |
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$ |
646,767 |
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Lease obligation, current |
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152,224 |
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150,095 |
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Accrued expenses and other current liabilities |
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2,034,525 |
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2,259,955 |
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Insurance premium financing payable |
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177,256 |
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381,784 |
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Total current liabilities |
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3,704,543 |
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3,438,601 |
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Lease obligation, net of current portion |
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25,606 |
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90,124 |
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Total liabilities |
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3,730,149 |
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3,528,725 |
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Commitments and contingencies (see Note 13) |
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Stockholders’ equity: |
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Preferred stock, $0.001 par value; 10,000,000 shares authorized; 0 shares issued and outstanding at June 30, 2024 and December 31, 2023 |
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— |
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— |
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Common stock, $0.001 par value; 100,000,000 shares authorized; 7,216,145 and 6,186,280 shares issued and outstanding at June 30, 2024 and December 31, 2023 |
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7,216 |
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6,186 |
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Additional paid-in capital |
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81,600,425 |
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77,871,584 |
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Accumulated other comprehensive (loss) income |
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(1,024 |
) |
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877 |
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Accumulated deficit |
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(76,509,968 |
) |
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(66,900,725 |
) |
Total stockholders' equity |
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5,096,649 |
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10,977,922 |
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Total liabilities and stockholders’ equity |
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$ |
8,826,798 |
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$ |
14,506,647 |
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See accompanying notes to condensed consolidated financial statements.
Inhibikase Therapeutics, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(Unaudited)
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Three Months Ended June 30, |
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Six Months Ended June 30, |
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2024 |
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2023 |
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2024 |
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2023 |
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Revenue: |
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Grant revenue |
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$ |
— |
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$ |
116,410 |
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$ |
— |
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$ |
180,931 |
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Total revenue |
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— |
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116,410 |
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— |
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180,931 |
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Costs and expenses: |
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Research and development |
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3,075,830 |
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4,535,698 |
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5,827,109 |
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7,389,817 |
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Selling, general and administrative |
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1,974,705 |
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1,783,113 |
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4,005,786 |
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3,708,464 |
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Total costs and expenses |
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5,050,535 |
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6,318,811 |
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9,832,895 |
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11,098,281 |
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Loss from operations |
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(5,050,535 |
) |
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(6,202,401 |
) |
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(9,832,895 |
) |
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(10,917,350 |
) |
Interest income |
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90,927 |
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424,435 |
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223,652 |
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661,606 |
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Net loss |
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(4,959,608 |
) |
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(5,777,966 |
) |
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(9,609,243 |
) |
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(10,255,744 |
) |
Other comprehensive income (loss), net of tax |
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Unrealized gains (loss) on marketable securities |
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776 |
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(167,536 |
) |
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(1,901 |
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(106,432 |
) |
Comprehensive loss |
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$ |
(4,958,832 |
) |
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$ |
(5,945,502 |
) |
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$ |
(9,611,144 |
) |
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$ |
(10,362,176 |
) |
Net loss per share – basic and diluted |
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$ |
(0.66 |
) |
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$ |
(0.94 |
) |
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$ |
(1.38 |
) |
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$ |
(1.74 |
) |
Weighted-average number of common shares – basic and diluted |
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7,535,667 |
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6,162,280 |
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6,939,779 |
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5,883,895 |
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See accompanying notes to condensed consolidated financial statements.
Inhibikase Therapeutics, Inc.
Condensed Consolidated Statements of Stockholders' Equity
(Unaudited)
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Common Stock |
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Shares |
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Amount |
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Additional Paid-In Capital |
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Accumulated Other Comprehensive Income (Loss) |
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Accumulated Deficit |
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Total Stockholders’ Equity |
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Balance at December 31, 2023 |
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6,186,280 |
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$ |
6,186 |
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$ |
77,871,584 |
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$ |
877 |
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$ |
(66,900,725 |
) |
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$ |
10,977,922 |
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Stock-based compensation expense |
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— |
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— |
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53,434 |
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— |
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— |
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53,434 |
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Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
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290,564 |
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291 |
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397,316 |
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— |
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— |
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397,607 |
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Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(2,677 |
) |
|
|
— |
|
|
|
(2,677 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(4,649,635 |
) |
|
|
(4,649,635 |
) |
Balance at March 31, 2024 |
|
|
6,476,844 |
|
|
|
6,477 |
|
|
|
78,322,334 |
|
|
|
(1,800 |
) |
|
|
(71,550,360 |
) |
|
|
6,776,651 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
30,697 |
|
|
|
— |
|
|
|
— |
|
|
|
30,697 |
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
739,301 |
|
|
|
739 |
|
|
|
3,247,394 |
|
|
|
— |
|
|
|
— |
|
|
|
3,248,133 |
|
Other comprehensive income |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
776 |
|
|
|
— |
|
|
|
776 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(4,959,608 |
) |
|
|
(4,959,608 |
) |
Balance at June 30, 2024 |
|
|
7,216,145 |
|
|
$ |
7,216 |
|
|
$ |
81,600,425 |
|
|
$ |
(1,024 |
) |
|
$ |
(76,509,968 |
) |
|
$ |
5,096,649 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common Stock |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Shares |
|
|
Amount |
|
|
Additional Paid-In Capital |
|
|
Accumulated Other Comprehensive Income (Loss) |
|
|
Accumulated Deficit |
|
|
Total Stockholders’ Equity |
|
Balance at December 31, 2022 |
|
|
4,224,294 |
|
|
$ |
4,224 |
|
|
$ |
68,798,301 |
|
|
$ |
104,718 |
|
|
$ |
(47,871,842 |
) |
|
$ |
21,035,401 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
123,273 |
|
|
|
— |
|
|
|
— |
|
|
|
123,273 |
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
971,532 |
|
|
|
972 |
|
|
|
8,541,970 |
|
|
|
— |
|
|
|
— |
|
|
|
8,542,942 |
|
Other comprehensive income |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
61,104 |
|
|
|
— |
|
|
|
61,104 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(4,477,778 |
) |
|
|
(4,477,778 |
) |
Balance at March 31, 2023 |
|
|
5,195,826 |
|
|
|
5,196 |
|
|
|
77,463,544 |
|
|
|
165,822 |
|
|
|
(52,349,620 |
) |
|
|
25,284,942 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
124,845 |
|
|
|
— |
|
|
|
— |
|
|
|
124,845 |
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
95,000 |
|
|
|
95 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
95 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(167,536 |
) |
|
|
— |
|
|
|
(167,536 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(5,777,966 |
) |
|
|
(5,777,966 |
) |
Balance at June 30, 2023 |
|
|
5,290,826 |
|
|
$ |
5,291 |
|
|
$ |
77,588,389 |
|
|
$ |
(1,714 |
) |
|
$ |
(58,127,586 |
) |
|
$ |
19,464,380 |
|
See accompanying notes to condensed consolidated financial statements.
Inhibikase Therapeutics, Inc.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Cash flows from operating activities |
|
|
|
|
|
|
Net loss |
|
$ |
(9,609,243 |
) |
|
$ |
(10,255,744 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
Depreciation |
|
|
13,137 |
|
|
|
164,247 |
|
Stock-based compensation expense |
|
|
84,131 |
|
|
|
248,118 |
|
Changes in operating assets and liabilities: |
|
|
|
|
|
|
Accounts receivable |
|
|
— |
|
|
|
(39,721 |
) |
Operating lease right‑of‑use assets |
|
|
58,465 |
|
|
|
51,551 |
|
Prepaid expenses and other assets |
|
|
30,719 |
|
|
|
(380,471 |
) |
Prepaid research and development |
|
|
(86,483 |
) |
|
|
692,387 |
|
Accounts payable |
|
|
875,701 |
|
|
|
(397,027 |
) |
Operating lease liabilities |
|
|
(62,389 |
) |
|
|
(53,350 |
) |
Accrued expenses and other current liabilities |
|
|
(225,430 |
) |
|
|
(567,509 |
) |
Net cash used in operating activities |
|
|
(8,921,392 |
) |
|
|
(10,537,519 |
) |
|
|
|
|
|
|
|
Cash flows from investing activities |
|
|
|
|
|
|
Purchases of equipment and improvements |
|
|
— |
|
|
|
(14,238 |
) |
Purchases of investments - marketable securities |
|
|
(9,209,545 |
) |
|
|
(18,681,260 |
) |
Maturities of investments - marketable securities |
|
|
8,440,958 |
|
|
|
15,406,535 |
|
Net cash used in investing activities |
|
|
(768,587 |
) |
|
|
(3,288,963 |
) |
|
|
|
|
|
|
|
Cash flows from financing activities |
|
|
|
|
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
3,611,255 |
|
|
|
8,543,037 |
|
Net cash provided by financing activities |
|
|
3,611,255 |
|
|
|
8,543,037 |
|
Net decrease in cash and cash equivalents |
|
|
(6,078,724 |
) |
|
|
(5,283,445 |
) |
Cash and cash equivalents at beginning of period |
|
|
9,165,179 |
|
|
|
7,188,553 |
|
Cash and cash equivalents at end of period |
|
$ |
3,086,455 |
|
|
$ |
1,905,108 |
|
Supplemental disclosures of non-cash financing activities |
|
|
|
|
|
|
Non-cash financing costs |
|
$ |
(181,930 |
) |
|
|
— |
|
Supplemental disclosures of cash flow information |
|
|
|
|
|
|
Issuance costs |
|
$ |
1,203,350 |
|
|
$ |
1,456,479 |
|
See accompanying notes to condensed consolidated financial statements.
Inhibikase Therapeutics, Inc.
Notes to Unaudited Condensed Consolidated Financial Statements
We are a clinical-stage pharmaceutical company developing protein kinase inhibitor therapeutics to modify the course of Parkinson’s disease (“PD”), Parkinson’s-related disorders and other diseases of the Abelson Tyrosine Kinases. The Company’s multi-therapeutic pipeline has a primary focus on neurodegeneration and its lead program utilizing Risvodetinib (also known as IkT-148009), a selective inhibitor of the non-receptor Abelson Tyrosine Kinases, targets the treatment of Parkinson’s disease inside and outside the brain as well as other diseases that arise from Abelson Tyrosine Kinases. In 2021, we commenced clinical development of Risvodetinib (IkT-148009), which we believe can modify the course of Parkinson’s disease including its manifestation in the gastrointestinal tract, or GI. In January 2023, the Company initiated its Phase 2 program, termed ‘the 201 trial’ (www.the201trial.com), for Risvodetinib (IkT-148009) as a treatment for Parkinson’s disease. In June 2024, the 201 trial was fully enrolled.
We are also developing platform technologies to improve delivery of protein kinase inhibitors in patients. One example of our potential ability to improve drug delivery is IkT-001Pro, a prodrug of the anticancer agent imatinib mesylate, which is intended to treat Stable Phase Chronic Myelogenous Leukemia, or SP-CML. IkT-001Pro has completed a three-part dose finding/dose equivalence study in 66 healthy volunteers (known as ‘the 501 trial’).
We are also evaluating the application of IkT-001Pro to pulmonary arterial hypertension (PAH). The Company has filed an Investigational New Drug Application, or IND, with the Food and Drug Administration, or FDA.
For both IkT-148009 and IkT-001Pro, we have completed clinical batch manufacturing of a film-coated tablet formulation. The bioequivalence studies with IkT-001Pro have already implemented these tablets into the study. A pharmacokinetic bridging study with two different tablet formulations of IkT-148009 was completed in 2023.
The Company has incurred recurring losses. At June 30, 2024, the Company had working capital of $4,898,258, an accumulated deficit of $76,509,968, cash and cash equivalents of $3,086,455, marketable securities of $4,853,559 and accounts payable and accrued expenses of $3,375,063.
The future success of the Company is dependent on its ability to successfully obtain additional working capital, obtain regulatory approval for and successfully launch and commercialize its product candidates and to ultimately attain profitable operations. Historically, the Company has funded its operations primarily through cash received in connection with revenue from its various grant programs. In addition, in December 2020, June 2021, January 2023 and May 2024, the Company raised approximately $14.6 million, $41.1 million, $8.5 million and $3.2 million in net proceeds for working capital from its initial public offering (“IPO”), June 2021 Offering, January 2023 Offering and May 2024 Offering, respectively.
The Company is subject to a variety of risks similar to other early-stage life science companies including, but not limited to, the successful development, regulatory approval, and market acceptance of the Company’s product candidates, development by its competitors of new technological innovations, protection of proprietary technology, and raising additional working capital. The Company has incurred significant research and development expenses, general and administrative expenses related to its product candidate programs and negative cash flows from operations. The Company anticipates costs and expenses to increase in the future as the Company continues to develop its product candidates.
The Company may seek to fund its operations through additional public equity, private equity, or debt financings, as well as other sources. However, the Company may be unable to raise additional working capital, or if it is able to raise additional capital, it may be unable to do so on commercially favorable terms. The Company’s failure to raise capital or enter into such other arrangements if and when needed would have a negative impact on the Company’s business, results of operations and financial condition and the Company’s ability to continue to develop its product candidates.
The Company estimates that its working capital at June 30, 2024, including the funds raised from the May 2024 Offering is sufficient to fund its normal operations into December, 2024.
These conditions raise substantial doubt regarding the Company’s ability to continue as a going concern for a period of one year after the date the financial statements are issued. Management’s plan to alleviate the conditions that raise substantial doubt may include additional equity raises, suspending or delaying certain research projects and capital expenditures and eliminating certain future operating expenses in order to fund operations at reduced levels for the Company to continue as a going concern.
The accompanying condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and satisfaction of liabilities in the ordinary course of business. The condensed consolidated financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities that might result from the outcome of the uncertainties described above.
3.Basis of Presentation and Significant Accounting Policies
Basis of Presentation of Interim Financial Statements
The accompanying unaudited condensed consolidated financial statements were prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim financial statements and, in the opinion of management, include all normal and recurring adjustments necessary to present fairly the results of the interim periods shown. The December 31, 2023 balance sheet was derived from December 31, 2023 audited financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles (“US GAAP”) have been condensed or omitted pursuant to such SEC rules and regulations. Management believes that the disclosures made are adequate to make the information presented not misleading. The results for the interim periods are not necessarily indicative of results to be expected for the fiscal year ending December 31, 2024. The unaudited condensed consolidated financial statements contained herein should be read in conjunction with the Company’s annual audited financial statements and notes thereto for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC.
The unaudited condensed consolidated financial statements have been prepared in conformity with US GAAP, which prescribes elimination of all significant intercompany accounts and transactions in the accounts of the Company and its wholly-owned subsidiary, IKT Securities Corporation, Inc., which was incorporated in the Commonwealth of Massachusetts in December 2021. Any reference in these notes to applicable guidance is meant to refer to the authoritative US GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Update (“ASU”) of the Financial Accounting Standards Board (“FASB”).
From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies and are generally adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its financial position or results of operations upon adoption.
The Company qualifies as an “emerging growth company” as defined in the Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act. The JOBS Act permits an emerging growth company such as the Company to take advantage of an extended transition period to comply with new or revised accounting standards applicable to public companies until those standards would otherwise apply to private companies. The Company has elected not to “opt out” of such extended transition period, which means that when a standard is issued or revised and it has different application dates for public or private companies, the Company will adopt the new or revised standard at the time private companies adopt the new or revised standard and will do so until such time that it either (i) irrevocably elects to “opt out” of such extended transition period or (ii) no longer qualifies as an emerging growth company.
On June 30, 2023, we effected a reverse stock split at the ratio of 1 post-split share for every 6 pre-split shares. All common stock, options, warrant amounts, per share information and references have been retroactively adjusted for all figures presented to reflect this split unless specifically stated otherwise.
Use of Estimates
The preparation of the Company’s financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The Company utilizes certain estimates in the determination of our liquidity and working capital adequacy, the fair value of its stock options and warrants, deferred tax valuation allowances and revenue recognition, to record expenses relating to research and development contracts and accrued expenses. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from such estimates.
New Accounting Pronouncements
From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies that the Company adopts as of the specified effective date. Unless otherwise discussed below, the Company does not believe that the adoption of recently issued standards have or may have a material impact on its condensed consolidated financial statements and disclosures.
Concentrations of Credit Risk
For the three and six months ended June 30, 2024, the Company did not report any revenues. For the three and six months ended June 30, 2023, the Company derived 100% of its total revenue from a single source, the United States Government, in the form of federal research grants.
Revenue Recognition
The Company generates revenue from research and development grants under contracts with third parties that do not create customer-vendor relationships. The Company’s research and development grants are non-exchange transactions and are not within the scope of ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”). Contribution revenue earned from activities performed pursuant to research and development grants is reported as grant revenue in the Company’s unaudited condensed consolidated statements of operations and comprehensive loss. Revenue from these grants is recognized as the Company incurs qualifying expenses as stipulated by the terms of the respective grant. Cash received from grants in advance of incurring qualifying expenses is recorded as deferred revenue. The Company records revenue and a corresponding receivable when qualifying costs are incurred before the grants are received.
Research and Development Costs
Costs incurred in the research and development of the Company’s product candidates are expensed as incurred. Research and development expenses consist of costs incurred in performing research and development activities, including activities associated with performing services under grant revenue contracts and include salaries and benefits, stock compensation, research-related subcontractors and consultants, supplies and overhead costs. Advance payments made to suppliers and contract research organizations are classified as prepaid research and development and are expensed as research and development as the supplies are consumed and the contract services are provided. During the three and six months ended June 30, 2024, the Company incurred expenses of approximately $175 thousand and $297 thousand, respectively, with a related party vendor included in research and development expenses. During the three and six months ended June 30, 2023, the Company did not incur any expenses with a related party vendor that were included in research and development expenses. As at the period ended June 30, 2024 and December 31, 2023, the Company had a payable or accrued expense balance with a related party vendor of approximately $125 thousand and $57 thousand, respectively, included in accounts payable and accrued expenses.
Leases
The Company accounts for its leases under ASU 2021-09, ASU 2018-10, and ASC Topic 842, Leases (“ASC 842”). ASC 842 requires a lessee to record a right-of-use asset and a corresponding lease liability for most lease arrangements on the Company's balance sheet. Under the standard, disclosure of key information about leasing arrangements to assist users of the financial statements with assessing the amount, timing and uncertainty of cash flows arising from leases is required.
Leases are classified as either finance leases or operating leases. A lease is classified as a finance lease if any one of the following criteria are met: the lease transfers ownership of the asset by the end of the lease term, the lease contains an option to purchase the asset that is reasonably certain to be exercised, the lease term is for a major part of the remaining useful life of the asset or the present value of the lease payments equals or exceeds substantially all of the fair value of the asset. A lease is classified as an operating lease if it does not meet any of these criteria.
For all leases at the lease commencement date, a right-of-use asset and a lease liability are recognized. The right-of-use asset represents the right to use the leased asset for the lease term. The lease liability represents the present value of the lease payments under the lease.
The right-of-use asset is initially measured at cost, which primarily comprises the initial amount of the lease liability, plus any initial direct costs incurred if any, less any lease incentives received. All right-of-use assets are reviewed for impairment. The lease liability is initially measured at the present value of the lease payments, discounted using the interest rate implicit in the lease or, if that rate cannot be readily determined, the secured incremental borrowing rate for the same term as the underlying lease.
Lease payments included in the measurement of the lease liability comprise the following: the fixed noncancelable lease payments, payments for optional renewal periods where it is reasonably certain the renewal period will be exercised, and payments for early termination options unless it is reasonably certain the lease will not be terminated early.
Lease cost for operating leases consists of the lease payments plus any initial direct costs, primarily brokerage commissions, and is recognized on a straight-line basis over the lease term. Included in lease cost are any variable lease payments incurred in the period
that are not included in the initial lease liability and lease payments incurred in the period for any leases with an initial term of 12 months or less. Lease cost for finance leases consists of the amortization of the right-of-use asset on a straight-line basis over the lease term and interest expense determined on an amortized cost basis. The lease payments are allocated between a reduction of the lease liability and interest expense.
The Company has made an accounting policy election to not recognize leases with an initial term of 12 months or less within our condensed consolidated balance sheets and to recognize those lease payments on a straight-line basis in our condensed consolidated statements of operations and comprehensive loss over the lease term.
Equipment and Improvements
Equipment and improvements are stated at cost, less accumulated depreciation. For financial reporting purposes, depreciation is recognized using the straight-line method, allocating the cost of the assets over their estimated usefulness from three to five years for network equipment, office equipment, and furniture classified as fixed assets.
|
|
|
|
|
Estimated Useful Economic Life |
Leasehold property improvements, right-of-use assets |
|
Lesser of lease term or useful life |
Furniture and office equipment |
|
3-5 years |
Lab equipment |
|
3 years |
IT equipment |
|
3 years |
Fair Value Measurement
The Company has certain financial assets and liabilities recorded at fair value which have been classified as Level 1, 2 or 3 within the fair value hierarchy as described in the accounting standards for fair value measurements.
· Level 1 — Fair values are determined utilizing quoted prices (unadjusted) in active markets for identical assets or liabilities that the Company has the ability to access;
· Level 2 — Fair values are determined by utilizing quoted prices for identical or similar assets and liabilities in active markets or other market observable inputs such as interest rates, yield curves and foreign currency spot rates; and
· Level 3 — Inputs are unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement.
The Company’s financial assets, which include cash equivalents and marketable securities, have been initially valued at the transaction price, and subsequently revalued at the end of each reporting period, utilizing third-party pricing services. The pricing services utilize industry standard valuation models, including both income and market based approaches, to determine value and improvements are stated at cost, less accumulated depreciation.
Marketable Securities
The Company's marketable securities consist of U.S. Treasury securities with maturities of less than one year which are classified as available-for-sale and included in current assets on the condensed consolidated balance sheets. Available-for-sale debt securities are carried at fair value with unrealized gains and losses reported as a component of stockholders’ equity in accumulated other comprehensive income (loss). Realized gains and losses, if any, are included in other income, net in the condensed consolidated statements of operations and comprehensive loss.
Available-for-sale securities are reviewed for possible impairment at least quarterly, or more frequently if circumstances arise that may indicate impairment. When the fair value of the securities declines below the amortized cost basis, impairment is indicated and it must be determined whether it is other than temporary. Impairment is considered to be other than temporary if the Company: (i) intends to sell the security, (ii) will more likely than not be forced to sell the security before recovering its cost, or (iii) does not expect to recover the security’s amortized cost basis. If the decline in fair value is considered other than temporary, the cost basis of the security is adjusted to its fair market value and the realized loss is reported.
4.Fair Value of Financial Instruments
The following table summarizes cash equivalents and marketable securities measured at their fair value on a recurring basis as of June 30, 2024:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of June 30, 2024 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
Total |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
Total |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of December 31, 2023 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
Total |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Marketable securities consisted of the following as of:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
Total |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2023 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
As of June 30, 2024, the Company held 18 U.S. Treasury debt securities that were in an unrealized loss position totaling $1,024. As of December 31, 2023, the Company held three U.S. Treasury debt securities that were in an unrealized gain position totaling $877. All U.S. Treasury obligations were due to mature in less than one year for the period and year ended June 30, 2024 and December 31, 2023, respectively.
The Company received proceeds of $8.4 million from maturities of marketable securities for the six months ended June 30, 2024. The Company received proceeds of $41.1 million from maturities of marketable securities for the year ended December 31, 2023. The Company did not realize any gains or losses from maturities of marketable securities for the period ended June 30, 2024 or the year ended December 31, 2023.
6.Equipment and Improvements
|
|
|
|
|
|
|
|
|
Equipment and Improvements, net |
|
|
|
June 30, |
|
|
December 31, |
|
|
|
2024 |
|
|
2023 |
|
Furniture and office equipment |
|
$ |
86,930 |
|
|
$ |
86,930 |
|
IT equipment |
|
|
16,895 |
|
|
|
16,895 |
|
|
|
|
103,825 |
|
|
|
103,825 |
|
Less: Accumulated depreciation |
|
|
43,590 |
|
|
|
30,453 |
|
Total |
|
$ |
60,235 |
|
|
$ |
73,372 |
|
Depreciation expense for the three and six months ended June 30, 2024 was $6,569 and $13,137, respectively. Depreciation expense for the three and six months ended June 30, 2023 was $159,204 and $164,247, respectively.
7.Supplemental Balance Sheet Information
Accrued expenses and other current liabilities consist of the following:
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued consulting |
|
$ |
54,298 |
|
|
$ |
49,395 |
|
Accrued compensation |
|
|
486,956 |
|
|
|
635,451 |
|
Accrued research and development |
|
|
1,482,340 |
|
|
|
1,472,292 |
|
Accrued other |
|
|
10,931 |
|
|
|
102,817 |
|
Total accrued expenses and other current liabilities |
|
$ |
2,034,525 |
|
|
$ |
2,259,955 |
|
Each share of common stock is entitled to one vote. The holders of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the board of directors, subject to the prior rights of holders of all classes of stock outstanding. As of June 30, 2024, a total of 3,589,232 shares of common stock were reserved for issuance upon the exercise of outstanding stock options and warrants under the 2020 Equity Incentive Plan (the "2020 Plan") and the 2011 Equity Incentive Plan.
Share Issuances
On February 1, 2024, the Company entered into an At The Market Offering (the “ATM”) with H.C. Wainwright & Co., LLC as sales agent (the “Agent”), pursuant to which the Company may, from time to time, issue and sell shares of its common stock, at an aggregate offering price of up to approximately $5.7 million (the “Shares”) through the Agent. Under the terms of the Agreement, the Agent may sell the Shares at market prices by any method that is deemed to be an “ATM” as defined in Rule 415 under the Securities Act, as amended. On May 20, 2024, the Company reduced the aggregate offering price to $50,000, not including the shares of common stock previously sold.
Subject to the terms and conditions of the Agreement, the Agent will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company’s instructions. The Company has no obligation to sell any of the Shares, and may at any time suspend sales under the Agreement or terminate the Agreement in accordance with its terms. The Company has provided the Agent with customary indemnification rights, and the Agent will be entitled to a fixed commission of 3.0% of the aggregate gross proceeds from the Shares sold. The Agreement contains customary representations and warranties, and the Company is required to deliver customary closing documents and certificates in connection with sales of the Shares. As of June 30, 2024, 315,338 ATM Shares have been sold under the Agreement with net proceeds of $820,509 to the Company.
On May 20, 2024, the Company entered into a securities purchase agreement with a single institutional investor in connection with a registered direct offering and concurrent private placement with the same institutional investor (collectively the "May 2024 Offering"). The May 2024 Offering consisted of (i) 714,527 shares of the Company's common stock sold at $1.68 per share, (ii) Pre-Funded Common Warrants to purchase up to 957,925 shares of common stock with an exercise price of $0.0001 which are immediately exercisable after the issuance until exercised in full, (iii) Series A Common Warrants to purchase 1,672,452 shares of common stock with an exercise price of $1.68 per share which expire on the one-year anniversary from the date of stockholder approval, and (iv) Series B Common Warrants to purchase 1,672,452 shares of common stock with an exercise price of $1.68 per
share which expire on the five-year anniversary from the date of stockholder approval. All of the warrants in the May 2024 Offering were issued to a single investor. As of the date of issuance, the investor exercised 247,925 Pre-Funded Common Warrants. The Company received net proceeds from the May 2024 Offering of approximately $2.2 million.
On May 20, 2024, the Company also entered into a warrant inducement agreement with the same investor to exercise certain outstanding warrants that the Company issued in January 2023 ("January 2023 Existing Warrants"). Pursuant to the warrant inducement agreement, the investor agreed to exercise outstanding warrants to purchase an aggregate of 708,500 shares of the Company's common stock at an amended exercise price of $1.68 per share. These shares are held in abeyance and not considered outstanding. The shares held in abeyance will be held in abeyance until notice from the investor that the balance, or portion thereof, may be issued in compliance with a beneficial ownership limitation provision in the warrants. The Company also agreed to reduce the exercise price of the remaining unexercised portion of such warrants to purchase 1,229,484 shares of common stock to $1.68 per share and to issue the investor Series C Common Warrants to purchase 708,500 shares of the Company's common stock and Series D Common Warrants to purchase 708,500 shares of the Company's common stock ("January 2023 New Warrants"). Each will have an exercise price of $1.68 per share and will be exercisable beginning on the effective date of stockholder approval. The Series C Common Warrants will expire on the one-year anniversary from the date of stockholder approval and the Series D Common Warrants will expire on the five-year anniversary from the date of stockholder approval.
The repricing of the January 2023 Existing Warrants and issuance of the Series C Common Warrants and the Series D Common Warrants is considered a modification of the January 2023 Existing Warrants under the guidance of ASU 2021-04. The modification is consistent with the "Equity Issuance" classification under that guidance as the reason for the modification was to induce the holder to cash exercise their warrants, resulting in the imminent exercise of the January 2023 Existing Warrants, which raised equity capital and generated net proceeds for the Company of approximately $1.0 million. The total fair value of the consideration of the modification includes the incremental fair value of the January 2023 Existing Warrants (determined by comparing the fair values immediately prior to and immediately after the modification) and the initial fair value of the January 2023 New Warrants. The fair values were calculated using the Black-Scholes model and the Company determined that the total fair value of the consideration related to the modification of the January 2023 Existing Warrants, including the initial fair value of the January 2023 New Warrants was $1.8 million.
9.Stock-Based Compensation
2020 Equity Incentive Plan
The Company’s 2020 Plan was established for granting stock incentive awards to directors, officers, employees and consultants to the Company.
Stock Options
During the six months ended June 30, 2024, the Company granted 188,039 options with a weighted average strike price of $2.12 to purchase common stock to certain employees that either (i) vest annually in three equal parts over three years or (ii) vest on the first anniversary of the grant of such option in the mount of one-third of such grant, and the remaining portion will vest in 24 equal monthly installments thereafter. The Company granted 45,000 performance-based options with a weighted average strike price of $2.16 to purchase common stock to certain employees. These options are subject to performance vesting and will vest and become exercisable once the performance conditions are probable of being met. There is no assurance that the performance conditions will be met and therefore some or all of these options may never vest or become exercisable. The total aggregate grant date fair value of all options granted was $359,032. During the three months ended June 30, 2024, certain performance conditions were met.
During the six months ended June 30, 2023, the Company granted 86,669 options with a weighted average strike price of $2.81 to purchase common stock to certain employees that will either (i) vest annually in three equal parts over three years or (ii) vest on the first anniversary of the grant of such option in the amount of one-third of such grant, and the remaining portion will vest in 24 equal monthly installments thereafter. The Company granted 25,000 performance-based options with a weighted average strike price of $1.33 to purchase common stock to certain employees. These options are subject to performance vesting and will vest and become exercisable once the performance conditions have been met. There is no assurance that the performance conditions will be met and therefore some or all of these options may never vest or become exercisable. The total aggregate grant date fair value of all options granted was $338,738. During the six months ended June 30, 2023, no performance conditions were met.
For awards with performance conditions in which the award does not vest unless the performance condition is met, we recognize expense if, and to the extent that, we estimate that achievement of the performance condition is probable. If we conclude that vesting is probable, we recognize expense from the date we reach this conclusion through the estimated vesting date.
Stock-Based Compensation Expense
The following table summarizes the stock-based compensation expense for stock options granted to employees and non-employees:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Research and development |
|
$ |
(7,706 |
) |
|
$ |
40,259 |
|
|
$ |
10,224 |
|
|
$ |
78,876 |
|
Selling, general and administrative |
|
|
38,403 |
|
|
|
84,586 |
|
|
|
73,907 |
|
|
|
169,242 |
|
Total stock-based compensation expense |
|
$ |
30,697 |
|
|
$ |
124,845 |
|
|
$ |
84,131 |
|
|
$ |
248,118 |
|
On February 1, 2024, the Company entered into an At The Market Offering (the “ATM”) with H.C. Wainwright & Co., LLC as sales agent (the “Agent”), pursuant to which the Company may, from time to time, issue and sell shares of its common stock, at an aggregate offering price of up to approximately $5.7 million (the “Shares”) through the Agent. Under the terms of the Agreement, the Agent may sell the Shares at market prices by any method that is deemed to be an “ATM” as defined in Rule 415 under the Securities Act, as amended. On May 20, 2024, the Company reduced the aggregate offering price to $50,000, not including the shares of common stock previously sold.
Subject to the terms and conditions of the Agreement, the Agent will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company’s instructions. The Company has no obligation to sell any of the Shares, and may at any time suspend sales under the Agreement or terminate the Agreement in accordance with its terms. The Company has provided the Agent with customary indemnification rights, and the Agent will be entitled to a fixed commission of 3.0% of the aggregate gross proceeds from the Shares sold. The Agreement contains customary representations and warranties, and the Company is required to deliver customary closing documents and certificates in connection with sales of the Shares. As of June 30, 2024, 315,338 ATM Shares have been sold under the Agreement with net proceeds of $820,509 to the Company.
The following table presents the calculation of basic and diluted net loss per share applicable to common stockholders. Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted-average number of shares outstanding during the period which includes pre-funded warrants and shares held in abeyance from date of issuance.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(4,959,608 |
) |
|
$ |
(5,777,966 |
) |
|
$ |
(9,609,243 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
7,535,667 |
|
|
|
6,162,280 |
|
|
|
6,939,779 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.66 |
) |
|
$ |
(0.94 |
) |
|
$ |
(1.38 |
) |
|
$ |
(1.74 |
) |
The following shares were excluded from the calculation of diluted net loss per share applicable to common stockholders, prior to the application of the treasury stock method, because their effect would have been anti-dilutive for the periods presented:
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Options to purchase shares of stock |
|
|
1,020,280 |
|
|
|
835,913 |
|
Warrants to purchase shares of stock |
|
|
7,985,965 |
|
|
|
3,137,590 |
|
Total |
|
|
9,006,245 |
|
|
|
3,973,503 |
|
During the three and six months ended June 30, 2024 and 2023, there was no provision for income taxes as the Company incurred losses during those periods. Deferred tax assets and liabilities reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. The Company recorded a full valuation allowance against its deferred tax assets as the Company believes it is more likely than not the deferred tax assets will not be realized.
13.Commitments and Contingencies
Litigation
On April 26, 2024, the Company received a notice of a demand for arbitration with the American Arbitration Association from Pivot Holding LLC (“Pivot”), that alleges to be a successor in interest to Sphaera Pharma Pte. Ltd. (“Sphaera”), in connection with the Collaborative Research and Development Agreement dated February 29, 2012, as amended, between the Company and Sphaera (the "Agreement"). Pivot alleges breach of contract by the Company for failure to pay milestone payments and seeks damages of $1.625 million in milestone payments plus interest. The Company believes that Pivot’s claims are without merit and that the Company hasn’t owed and doesn’t owe any milestone payments to Pivot. The Company intends to vigorously dispute Pivot’s claims. The parties have agreed to mediate before arbitrating and a mediation is scheduled for September 6, 2024.
On June 17, 2024, the Company filed an answering statement and counterclaim, in which Inhibikase disputed Pivot’s claims and counterclaimed that Sphaera had breached the Agreement by failing to complete properly the drug development work required by the Agreement, causing the Company over $900,000 in damages.
Lease
On April 18, 2022, the Company entered into an operating lease agreement for office space at its new location in Lexington, Massachusetts (the "Office Lease"). On August 8, 2022, the Company commenced occupancy of the leased space. The lease runs through September 30, 2025. We have an option to extend the lease term for an additional three (3) years thereafter.
The Company accounts for the Office Lease under the provisions of ASC 842. We recorded a right-of-use asset and a corresponding operating lease liability on the Company's condensed consolidated balance sheets upon the accounting commencement date in August 2022. The lease liability was measured at the accounting commencement date utilizing a 12% discount rate. The right-of-use asset had a balance of $163,762 at June 30, 2024. The operating lease obligations totaled $177,830 at June 30, 2024, of which $152,224 is included under current liabilities and $25,606 is included under non-current liabilities. The Company recorded lease expense of $32,296 and $70,591 and other short-term payments of $5,653 and $11,306 for the three and six months ended June 30, 2024, respectively in selling, general and administrative expenses and lease expense relating to the Office Lease of $35,296 and $70,591 and other short-term payments of $5,788 and $11,576 for the three and six months ended June 30, 2023, respectively in selling, general and administrative expenses.
The Office Lease contains escalating payments during the lease period. Upon execution of the Office Lease, the Company prepaid one month of rent and a security deposit, one of which will be held in escrow and credited at the termination of the lease and the other of which will be applied to the first month’s rent.
As of June 30, 2024, a security deposit of approximately $25,000 was included in prepaid expenses and other current assets on the Company’s condensed consolidated balance sheet related to the Office Lease.
Future minimum lease payments under this lease at June 30, 2024, are presented by calendar year as follows:
|
|
|
|
|
Year |
|
|
|
2024 |
|
$ |
75,580 |
|
2025 |
|
|
114,966 |
|
Total lease payments |
|
|
190,546 |
|
Less: imputed interest |
|
|
(12,716 |
) |
Present value of operating lease liabilities |
|
$ |
177,830 |
|
14. Correction of Prior Period Immaterial Error:
The Company has identified an immaterial error in the Company's previously issued consolidated financial statements related to net loss per share and weighted-average number of common shares outstanding. The error pertains to the exclusion of pre-funded warrants from the January 2023 transaction in the weighted-average number of common shares used in the calculation of net loss per share, the effect of which improves net loss per share.
In evaluating whether the previously issued Consolidated Financial Statements were materially misstated for the interim or annual periods prior to December 31, 2023, the Company applied the guidance of ASC 250, Accounting Changes and Error Corrections, SEC Staff Accounting Bulletin (“SAB”) Topic 1.M, Assessing Materiality and SAB Topic 1.N, Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements and concluded that the effect of the errors on prior period annual financial statements was immaterial. The guidance states that prior-year misstatements which, if corrected in the current year would materially misstate the current year’s financial statements, must be corrected by adjusting prior year financial statements, even though such correction previously was and continues to be immaterial to the prior-year financial statements. This is because if left uncorrected over time the difference to weighted-average shares outstanding could have grown to be material. Correcting prior-year financial statements for such immaterial misstatements does not require previously filed reports to be amended.
The adjustment required to correct the misstatement in the financial statements for the three and six months ended June 30, 2023 is reflected in these consolidated statements of operations which are presented on a comparative basis with those for the three and six months ended June 30, 2024.
In accordance with ASC 250, Accounting Changes and Error Correction, the Company is hereby reporting the correction of the weighted-average common shares outstanding and net loss per share line items of its consolidated interim statements of operations for 2023 and its consolidated 2023 statement of operations.
The Company's consolidated statements of operations have been revised from the amounts previously reported to correct the error as shown in the tables below.
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended March 31, |
|
|
Three Months Ended March 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,477,778 |
) |
|
$ |
(4,477,778 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,585,013 |
|
|
|
5,582,631 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.98 |
) |
|
$ |
(0.80 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended June 30, |
|
|
Three Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(5,777,966 |
) |
|
$ |
(5,777,966 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,226,101 |
|
|
|
6,162,280 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(1.11 |
) |
|
$ |
(0.94 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Six Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(10,255,744 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,918,206 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.09 |
) |
|
$ |
(1.74 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended September 30, |
|
|
Three Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,595,199 |
) |
|
$ |
(4,595,199 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,342,337 |
|
|
|
6,162,671 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.86 |
) |
|
$ |
(0.75 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Nine Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(14,850,943 |
) |
|
$ |
(14,850,943 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,060,447 |
|
|
|
5,977,841 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.93 |
) |
|
$ |
(2.48 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Year ended December 31, |
|
|
Year ended December 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(19,028,883 |
) |
|
$ |
(19,028,883 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted (restated) |
|
|
5,333,096 |
|
|
|
6,028,210 |
|
Net loss per share applicable to common stockholders – basic and diluted (restated) |
|
$ |
(3.57 |
) |
|
$ |
(3.16 |
) |
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
Forward-Looking Statements
This Quarterly Report on Form 10-Q (“Report”) (including but not limited to this Item 2, “Management’s Discussion and Analysis of Financial Condition and Results of Operations”) contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), that are intended to qualify for the “safe harbor” created by those sections. In addition, we may make forward-looking statements in other documents filed with or furnished to the SEC, and our management and other representatives may make forward-looking statements orally or in writing to analysts, investors, representatives of the media and others. You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited condensed consolidated financial statements and the related notes to those statements included elsewhere in this Report. This discussion and analysis and other parts of this Report contain forward-looking statements based upon current beliefs, plans and expectations related to future events and our future financial performance that involve risks, uncertainties and assumptions, such as statements regarding our intentions, plans, objectives, expectations, forecasts and projections. Our actual results and the timing of selected events could differ materially from those anticipated in these forward-looking statements as a result of several factors.
All statements included or incorporated by reference in this Report, other than statements or characterizations of historical fact, are forward-looking statements. Forward-looking statements can generally be identified by the fact that they do not relate strictly to historical or current facts and include, but are not limited to, statements using terminology such as “can”, “may”, “could”, “should”, “assume”, “forecasts”, “believe”, “designed to”, “will”, “expect”, “plan”, “anticipate”, “estimate”, “potential”, “position”, “predicts”, “strategy”, “guidance”, “intend”, “seek”, “budget”, “project” or “continue”, or the negative thereof or other comparable terminology regarding beliefs, plans, expectations or intentions regarding the future. You should read statements that contain these words carefully because they:
•discuss our future expectations;
•contain projections of our clinical trials, future results of operations or of our financial condition; and
•state other “forward-looking” information.
We believe it is important to communicate our expectations. However, forward-looking statements are based on our current expectations, assumptions, estimates, approximations and projections about our business and our industry and management’s beliefs, all of which are subject to change. Forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and other factors. Accordingly, our actual results and the timing of certain events may differ materially and adversely from those expressed or implied in such forward-looking statements due to a variety of factors and risks, including, but not limited to, those set forth in this Item 2, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and in our unaudited condensed consolidated financial statements and notes thereto included in this Report, those set forth from time to time in our other filings with the SEC, including our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, and the following factors and risks:
•We are a clinical-stage drug development company with limited resources, a limited operating history and have no products approved for commercial sale, which may make it difficult to evaluate our current business and predict our future success and viability;
•If we are unable to successfully raise additional capital, our future clinical trials and product development could be limited and our long-term viability may be threatened;
•There is substantial doubt regarding our ability to continue as a going concern and our independent registered public accounting firm has included an explanatory paragraph relating to our ability to continue as a going concern in its report on our audited financial statements included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023. We will need to raise additional funding, which may not be available on acceptable terms, or at all. Failure to obtain this necessary capital when needed may force us to delay, limit or terminate our clinical trials or other operations;
•While the U.S. Food and Drug Administration, or FDA, lifted the clinical holds with respect to the Risvodetinib (IkT-148009) programs relating to Parkinson’s disease and Multiple System Atrophy, or MSA, we may be subject to further clinical holds by the FDA in the future;
•Drug development is a highly uncertain undertaking and involves a substantial degree of risk. We have never generated any revenue from product sales, we may never generate any revenue from product sales, and we may fail to generate further revenue from grants or contracts or to be profitable;
•The wars between Russia and Ukraine and between Israel and Hamas could materially adversely affect our business, results of operations, and financial condition;
•Our results of operations have been adversely affected and, in the future, could be materially adversely impacted by the COVID-19 virus;
•Adverse developments affecting financial institutions, companies in the financial services industry or the financial services industry generally, including those we do business with, could adversely affect our operations and liquidity;
•We have incurred significant net losses since our inception and anticipate that we will continue to incur net losses for the foreseeable future;
•Due to the significant resources required for the development of our programs, and depending on our ability to access capital, we must prioritize development of certain product candidates;
•Our business is highly dependent on the success of our initial product candidates targeting neurodegenerative diseases;
•We currently contract with various research institutions to perform the research and development activities needed to develop our products, and if we ever choose to or need to find alternative research institutions, we may not be able to do so at all or, if we are able to do so, it may be costly and may cause significant delays in the development and commercialization of our products;
•Positive results from early preclinical or clinical studies of our product candidates are not necessarily predictive of the results of later preclinical studies and any current and future clinical trials of our product candidates;
•We have no history of completing clinical trials for novel drug substances or commercializing pharmaceutical products, which may make it difficult to evaluate the prospects for our future viability;
•Our clinical trials may reveal significant adverse events, toxicities or other side effects not seen in our preclinical studies and may result in a safety profile that could inhibit regulatory approval or market acceptance of any of our product candidates;
•We have concentrated much of our research and development efforts on the treatment of neurodegenerative diseases, a field that has seen limited success in drug development;
•We may encounter substantial delays in our current and planned clinical trials, or may not be able to conduct or complete our clinical trials on the timelines we expect, if at all;
•Our current and planned clinical trials may fail to demonstrate substantial evidence of the safety and efficacy of our product candidates, which would prevent, delay or limit the scope of regulatory approval and commercialization;
•Clinical development is a lengthy and expensive process with an uncertain outcome, and failure can occur at any stage of clinical development;
•The manufacture of our product candidates is complex and difficulties may be encountered in production;
•If, in the future, we are unable to establish sales and marketing capabilities or enter into agreements with third parties to sell and market any product candidates we may develop, we may not be successful in commercializing those product candidates if and when they are approved;
•Even if any product candidates we develop receive marketing approval, they may fail to achieve the degree of market acceptance by physicians, patients, healthcare payors, and others in the medical community necessary for commercial success;
•Even if we are able to commercialize any product candidates, such products may become subject to unfavorable pricing regulations, third-party reimbursement practices, or healthcare reform initiatives, which would harm our business;
•The regulatory approval processes of the FDA, European Medicines Agency, and comparable foreign regulatory authorities are lengthy, time consuming, and inherently unpredictable. Regulatory authorities have substantial discretion in the approval process and may refuse to accept an application, may disagree with our regulatory strategy or proposed pathway for approval or may decide that our data are insufficient for approval and require additional preclinical, clinical or other studies;
•We expect to depend in whole or in part on collaborations with third parties for the research, development and commercialization of any product candidates we may develop;
•We contract with third parties for the manufacture of materials for our research programs, preclinical studies and current clinical trials and expect to continue to do so for any future clinical trials and for commercialization of any product candidates that we may develop;
•We depend on a small number of third-party suppliers for key raw materials used in the manufacturing processes for our product candidates, and the loss of these third-party suppliers or their inability to supply us with adequate raw materials could harm our business; and
•If we are unable to obtain and maintain patent protection for any product candidates we develop, our competitors could develop and commercialize products or technology similar or identical to ours, and our ability to successfully commercialize any product candidates we may develop, and our technology may be adversely affected.
•We have identified a material weakness in our internal control over financial reporting as of June 30, 2024 relating to a non-routine transaction associated with pre-funded warrants that impacted the calculation of net loss per share. If we are not able to remediate this material weakness, or if we experience additional material weaknesses or other deficiencies in our internal control over financial reporting in the future or otherwise fail to maintain an effective system of internal control over financial reporting, we may not be able to accurately or timely report our financial results, and we may conclude that our internal control over financial reporting is not effective, which may adversely affect our business.
Any or all of our forward-looking statements may turn out to be wrong. They may be affected by inaccurate assumptions that we might make or by known or unknown risks and uncertainties. Actual outcomes and results may differ materially from what is expressed or implied in our forward-looking statements.
All forward-looking statements included in this Report are made as of the date hereof, in each case based on information available to us as of the date hereof, and we assume no obligations to update any forward-looking statement or risk factor, unless we are required to do so by law. If we do update one or more forward-looking statements, no inference should be drawn that we will make updates with respect to other forward-looking statements or that we will make any further updates to those forward-looking statements at any future time.
Forward-looking statements may include our plans and objectives for future operations, including plans and objectives relating to our product candidates and our future economic performance, projections, business strategy and timing and likelihood of success. Assumptions relating to the forward-looking statements included in this Report involve judgments with respect to, among other things, future economic, competitive and market conditions, future business decisions, and the time and money required to successfully complete development and commercialization of our product candidates, all of which are difficult or impossible to predict accurately and many of which are beyond our control.
Any of the assumptions underlying the forward-looking statements contained in this Report could prove inaccurate and, therefore, we cannot assure you that any of the results or events contemplated in any of such forward-looking statements will be realized. Based on the significant uncertainties inherent in these forward-looking statements, the inclusion of any such statement should not be regarded as a representation or as a guarantee by us that our objectives or plans will be achieved, and we caution you against relying on any of the forward-looking statements contained herein.
Correction of Prior Period Immaterial Error
The accompanying Management’s Discussion and Analysis of Financial Condition and Results of Operations gives effect to the correction of prior period immaterial errors in the previously reported Condensed Consolidated Financial Statements. For additional information and a detailed discussion of the correction, see Note 14, “Correction of Prior Period Immaterial Errors.”
Overview
We are a clinical-stage pharmaceutical company developing protein kinase inhibitor therapeutics to modify the course of Parkinson’s disease (“PD”), Parkinson’s-related disorders and other diseases of the Abelson Tyrosine Kinases. The Company’s multi-therapeutic pipeline has a primary focus on neurodegeneration and its lead program utilizing Risvodetinib (also known as IkT-148009), a selective inhibitor of the non-receptor Abelson Tyrosine Kinases, targets the treatment of Parkinson’s disease inside and outside the brain as well as other diseases that arise from Abelson Tyrosine Kinases. In 2021, we commenced clinical development of Risvodetinib (IkT-148009), which we believe can modify the course of Parkinson’s disease including its manifestation in the gastrointestinal, or GI, tract. In January 2023, the Company initiated its Phase 2 program, termed ‘the 201 trial’, for Risvodetinib (IkT-148009) as a treatment for Parkinson’s disease and began the process of opening up to 32 sites in the U.S. As of June 17, 2024, 32 sites are open and the trial was fully enrolled. As of June 29, 2024, 41 mild and 8 moderate possibly treatment-related adverse events
have been reported across all enrolled patients taking Risvodetinib (IkT-148009). Results from this trial will be reported in the fourth quarter of 2024. This multi-dose study is planned to be extended by up to 12 months subject to additional financing. In addition, emerging biomarker data from the 201 trial evaluating pathological alpha-synuclein in multiple tissues and fluids supported our recent grant submissions to the National Institute of Neurological Disease and Stroke. One of these grants, if approved, will introduce our novel monoclonal antibody to track phospho-Tyr-alpha-synuclein in the clinical trial setting, which we believe in turn will enhance the meaning of biomarker measurements. We believe the utilization of this antibody in tissue biopsy and fluid analysis will enable us to confirm target engagement and evaluate the effect of Risvodetinib (IkT-148009) on the underlying pathology responsible for disease.
The twelve-week 201 trial is evaluating three doses in participants who have untreated Parkinson’s disease on a staggered schedule and is placebo controlled with 1:1:1:1 randomization. The primary endpoints of this trial are safety and tolerability and a hierarchy of 15 secondary endpoints will evaluate treatment benefit in the brain and GI tract. The recent analysis of 11 patients who participated in the 201 trial prior to the temporary clinical hold issued by the FDA in November, 2022, which was lifted in January, 2023, suggested that Risvodetinib (IkT-148009) may have some effect on disease. These participants were withdrawn from the trial following the FDA’s temporary clinical hold. As detailed at the Movement Disorder Society Congress held August 2023, a key secondary endpoint is a functional assessment comprised of the sum of Parts 2 and 3 of the Movement Disorder Society Universal Parkinson’s Disease Rating Scale (MDS-UPDRS Parts II+III). This sum showed an average -8.7 point improvement in the three participants on the 200 mg dose relative to baseline, while three placebo participants increased by +1.7 points; this represents an average spread of -10.4 points. A lower (or negative) change relative to placebo of greater than -3 to -6 points might be considered a measure of improvement. Given the small sample size on this dose, we believe it is premature to conclude a clinical benefit, but this observation reinforces our desire to extend the trial for an additional 12 months to potentially obtain a clear picture of clinical benefit over a total measurement of 15 months. Blinded functional assessment and biomarker data supports the trial extension and may reinforce the observations made from the 11 unblinded patients.
In March 2023, we opened our Investigational New Drug Application, or IND, for Risvodetinib (IkT-148009) as a treatment for the Parkinson’s-related orphan disease Multiple System Atrophy, or MSA. Our evaluation of Risvodetinib (IkT-148009) in MSA was benefited by a grant received from the National Institute of Neurological Diseases and Stroke, an Institute of the National Institutes of Health, for $0.39 million to fund animal model studies of Risvodetinib (IkT-148009) as a therapy for MSA. Two different animal studies were undertaken to evaluate whether Risvodetinib (IkT-148009) could have an impact on disease in the animal. One model evaluated the ability of Risvodetinib (IkT-148009) to modify disease early in its progression, while the second model is evaluating whether Risvodetinib (IkT-148009) can correct functional loss much later in the disease course. The early progression model study has now been shown to preserve nearly normal functional activity following 20 weeks of once daily dosing relative to untreated controls. Preservation of function in this model occurred with substantial reduction of the underlying alpha-synuclein protein pathology. The second model evaluating Risvodetinib (IkT-148009) late in the disease course is ongoing. In addition, Risvodetinib (IkT-148009) was recently given Orphan Drug Designation by the FDA for the treatment of MSA. We are working with the National Institute of Neurological Diseases and Stroke to possibly initiate a Phase 2/3 program to evaluate Risvodetinib (IkT-148009) as a treatment for MSA through a clinical trial network supported by the Institute. The proposed Phase 2/3 study will have a primary efficacy endpoint following once daily dosing at one of two dose levels for twelve months. We plan to submit complementary regulatory documents for Risvodetinib (IkT-148009) to European Union authorities in 2024.
We are also developing platform technologies to improve delivery of protein kinase inhibitors in patients. One example of our potential ability to improve drug delivery is IkT-001Pro, a prodrug of the anticancer agent imatinib mesylate, which is intended to treat Stable Phase Chronic Myelogenous Leukemia, or SP-CML. A three-part dose finding/dose equivalence study in 66 healthy volunteers (known as ‘the 501 trial’) has been completed with IkT-001Pro. The study was designed to evaluate the 96-hour pharmacokinetics of imatinib delivered as IkT-001Pro and determine the dose of IkT-001Pro that can deliver the equivalent of either 400 mg or 600 mg imatinib mesylate. As of the date of this Report, bioequivalence to 400 mg imatinib mesylate has been established to our satisfaction for a 600 mg dose of IkT-001Pro. We further evaluated 600 mg imatinib mesylate and believe that a dose between 800 mg and 900 mg of IkT-001Pro is the preferred dose of IkT-001Pro to deliver a dose of imatinib equivalent to 600 mg imatinib mesylate. We studied 800 mg IkT-001Pro and found it to be nearly equivalent to 600 mg imatinib mesylate. We may study higher doses of IkT-001Pro to cover the full range of doses approved for imatinib mesylate to treat up to 11 adult and pediatric blood cancers.
On January 19, 2024, members of the Company along with its medical oncology consultants met with the FDA Review Team (the “Review Team”) from the Division of Hematologic Malignancies in a Pre-New Drug Application, or NDA, meeting to discuss our bioequivalence studies of IkT-001Pro and its path to approval. All questions were addressed and summarized in official meeting minutes issued by the FDA on February 12, 2024. During the meeting we inquired whether additional clinical studies may be needed to seek approval and discussed manufacturing and quality control requirements for approval. The Review Team acknowledged that the 505(b)(2) pathway appears to be the appropriate pathway for approval of IkT-001Pro and indicated that, pending formal review of our clinical data, clinical studies completed to date indicate that 600 mg and 800 mg IkT-001Pro provides similar exposures to 400 mg and 600 mg imatinib mesylate, respectively, subject to review of the NDA upon filing. In addition, given that imatinib mesylate is
approved for use between 300 mg and 800 mg once daily for a variety of blood and gastrointestinal cancers, the Review Team stated that if we intend to seek approval across all currently approved indications, we should evaluate additional dose(s) as needed to measure the safety, tolerability and bioequivalent dose of IkT-001Pro that would deliver up to 800 mg, the highest approved dose of imatinib mesylate. The Review Team also discussed the possible difference between IkT-001Pro and imatinib mesylate absorption in the gut and recommended that we evaluate whether IkT-001Pro and imatinib mesylate behave differently with respect to certain gut transporters that regulate absorption. This evaluation is now ongoing. Finally, a number of recommendations were discussed to prevent the potential mix-up between IkT-001Pro and imatinib mesylate either at the pharmacy or by patients for two drugs delivering the same active ingredient. We discussed alternate dosage forms for IkT-001Pro relative to imatinib mesylate as the primary mitigation strategy and will provide a justification of the dosage forms chosen and why they are unlikely to cause medication errors. To ensure that we meet the manufacturing requirements for approval, we will request milestone-based meetings with the Review Team as we complete the required manufacturing and quality control processes.
We are also evaluating the application of IkT-001Pro to pulmonary arterial hypertension (PAH). PAH is a rare disease of the pulmonary microvasculature with about 30,000 cases in the U.S., mostly in women between the ages of 30 and 60. The global PAH market size was valued at $7.66 billion in 2023 and is estimated to grow at a compound annual growth rate of 5.4% between 2024 to 2030. Most treatments for PAH attempt to address symptoms of this progressive disorder, but in the early 2010s, imatinib delivered by imatinib mesylate was shown to be a disease-modifying therapy for PAH. Co-administration of medications with harmful drug-drug interactions precluded the approval of imatinib as add-on therapy in PAH. Today, due to changes to standard-of-care for these patients, we believe the safety risk has been reduced and we plan to evaluate imatinib delivered by IkT-001Pro for PAH. As such, on April 5, 2024, members of the Company met with the FDA Division of Cardiology and Nephrology in a pre-IND meeting to discuss the Company’s plan to utilize IkT-001Pro at 300 mg or 450 mg in a Phase 2/3 efficacy, safety and tolerability trial in World Health Organization Functional Class I patients. At the meeting, the FDA confirmed that IkT-001Pro would be viewed as a New Molecular Entity (NME) for PAH and that the appropriate path for approval appears to be the 505(b)(2) statute. This opens up the possibility of IkT-001Pro being granted NME and patent exclusivity on approval. The period of exclusivity would be evaluated once the NDA is filed. The FDA requested that we conduct a comparative cell-culture based study of the hERG ion channel, a standard cardiovascular safety test performed for any NME for which a new IND is to be opened. The Company has completed this study and filed the IND on August 9, 2024. The Company is in active discussion with potential strategic partners on this program. The Company has also applied for Orphan Drug Designation for delivery of imatinib by IkT-001Pro for PAH.
We have also improved drug delivery of Risvodetinib (IkT-148009) through development of a tablet formulation, which we measured to nearly double the concentration of Risvodetinib (IkT-148009) delivered relative to the same dose previously administered as a gelatin capsule. This provides the opportunity to lower the effective oral dose, which could lead to further safety and tolerability improvements for Risvodetinib (IkT-148009). The Company plans to introduce the tablet formulation into the 12-month extension study, once implemented, as well as in all future clinical trials.
Finally, we are evaluating a number of research phase molecules (IkT-148x and BIP 4-7) for a variety of neurodegenerative disease indications across our pre-clinical development pipeline.
In our opinion, the multi-decade failures in the treatment of neurodegenerative diseases such as PD result from a lack of understanding of the biochemistry of the disease processes involved. Neurodegeneration is marked by a progressive degeneration and loss of function of neurons which send and receive signals to and from the brain. Historically, the cause of a neurodegenerative disease was thought to be a “plaque” made up of a misfolded and/or aggregated protein(s). Therapeutic approaches, therefore, sought to remove “plaque” from the brain. A “plaque”-focused treatment strategy has failed to alter the course of Parkinson’s disease in two Phase 2 trials that reported results in 2020 and 2021. We believe we are different. We identified the proteins that become dysfunctional in a disease pathway and sought to understand how a dysfunctional protein causes disease and published those results in several high-profile peer reviewed publications. We believe our approach to PD and other neurological diseases has identified the underlying cause of disease and led to an understanding of how individual proteins are linked together to define the disease process. We believe our approach to neurodegenerative disease is validated by our 2022 and 2023 publications and oral presentations at the major academic and industry conferences in Parkinson’s and Alzheimer’s diseases.
To increase the probability of success, we are making parallel investments in several product candidates and back-up candidates, and plan to advance only those candidates to the later stages of clinical development that show strong preclinical and early clinical data. By developing a portfolio of product candidates across therapeutic indications, we can continuously apply learnings and tools across programs and leverage economies of scale in our research and development organization. Our target indications include diseases with large patient populations, such as PD, as well as orphan indications, such as, Multiple System Atrophy and Chronic Myelogenous Leukemia.
We currently have commercialization rights to all of our development programs and patent protection in the United States until 2033 for IkT-001Pro and 2036 for Risvodetinib (IkT-148009). Additional patent filings could extend this period of exclusivity.
As of August 1, 2024, our patent portfolio included: (i) nine issued patents and four pending patent applications in the United States and (ii) eleven issued foreign patents and four pending foreign patent applications. The patents in this portfolio, and patents that may issue from the applications in this portfolio, will expire between 2033 and 2037, not taking into account any potential patent-term adjustments or extensions that may be available in the future.
Two families contain patents and applications covering (a) certain compositions of matter comprising IkT-001Pro; and (b) methods of treating certain diseases using IkT-001Pro. These families include two issued U.S. patents and one pending U.S. patent application. The patents will expire in 2033, not taking into account any potential patent-term adjustments or extensions that may be available in the future. The pending application is a U.S. provisional patent application that was filed in 2024. Future patent applications that are entitled to claim priority to this provisional application may issue as patents that would expire in 2044 or 2045, not taking into account any potential patent-term adjustments or extensions that may be available in the future.
Three families contain patents and applications covering (a) certain compositions of matter comprising IkT-148009 or IkT-01427; and (b) methods of treating certain diseases using IkT-148009 or IkT-01427. These families include seven issued U.S. patents and three pending U.S. patent applications. The patents within these families, and patents that may issue from the applications in these families, will expire between 2036 and 2037, not taking into account any potential patent-term adjustments or extensions that may be available in the future. One of the pending applications is a U.S. provisional patent application that was filed in 2024. Future patent applications that are entitled to claim priority to this provisional application may issue as patents that would expire in 2044 or 2045, not taking into account any potential patent-term adjustments or extensions that may be available in the future.
Components of Operating Results
Operating Expenses
Research and Development
Research and development activities account for a significant portion of our operating expenses. We record research and development expenses as incurred. Research and development expenses incurred by us for the discovery and development of our product candidates and prodrug technologies include:
•external research and development expenses, including expenses incurred under arrangements with third parties, such as CROs, preclinical testing organizations, clinical testing organizations, CMOs, academic and non-profit institutions and consultants;
•fees related to our license and collaboration agreements;
•personnel related expenses, including salaries, benefits and non-cash stock-based compensation expense; and
•other expenses, which include direct and allocated expenses for laboratory, facilities and other costs.
A portion of our research and development expenses are direct external expenses, which we track on a program-specific basis from inception of the program.
Program expenses include expenses associated with our most advanced product candidates and the discovery and development of compounds that are potential future candidates. We also track external expenses associated with our third-party research and development efforts. All external costs are tracked by therapeutic indication. We do not track personnel or other operating expenses incurred for our research and development programs on a program-specific basis. These expenses primarily relate to salaries and benefits and stock-based compensation and office consumables.
At this time, we can only estimate the nature, timing and costs of the efforts that will be necessary to complete the development of, and obtain regulatory approval for, any of our product candidates. We are also unable to predict when, if ever, material net cash inflows will commence from sales or licensing of our product candidates. This is due to the numerous risks and uncertainties associated with drug development, including the uncertainty of:
•our ability to add and retain key research and development personnel and other key employees;
•our ability to successfully file IND and NDA applications with the FDA;
•our ability to conduct and commence trials;
•our ability to establish an appropriate safety profile with IND-enabling toxicology studies;
•our ability to successfully develop, obtain regulatory approval for, and then successfully commercialize, our product candidates;
•our successful enrollment in and completion of our current and future clinical trials;
•the costs associated with the development of any additional product candidates we identify in-house or acquire through collaborations;
•our ability to discover, develop and utilize biomarkers to demonstrate target engagement, pathway engagement and the impact on disease progression of our molecules;
•our ability to establish agreements with third party manufacturers for clinical supply for any future clinical trials and commercial manufacturing, if our product candidates are approved;
•the terms and timing of any collaboration, license or other arrangement, including the terms and timing of any milestone payments thereunder;
•our ability to obtain and maintain patent, trade secret and other intellectual property protection and regulatory exclusivity for our product candidates if and when approved;
•our receipt of marketing approvals from applicable regulatory authorities;
•the impact of the outbreak of the COVID-19 pandemic or other future pandemics;
•our ability to commercialize products, if and when approved, whether alone or in collaboration with others; and
•the continued acceptable safety profiles of the product candidates following approval.
A change in any of these variables with respect to the development of any of our product candidates would significantly change the costs, timing and viability associated with the development of that product candidate. We expect our research and development expenses to increase for the next several years as we continue to implement our business strategy, advance our current programs, expand our research and development efforts, seek regulatory approvals for any product candidates that successfully complete clinical trials, access and develop additional product candidates and incur expenses associated with hiring additional personnel to support our research and development efforts. In addition, product candidates in later stages of clinical development generally incur higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of later-stage clinical trials.
Our direct research and development expenses consist principally of external costs, such as fees paid to investigators, consultants, central laboratories and CROs in connection with our clinical studies, and costs related to acquiring and manufacturing clinical study materials. We allocate salary and benefit costs directly related to specific programs. We do not allocate personnel-related discretionary bonus or stock-based compensation costs, laboratory and related expenses, depreciation or other indirect costs that are deployed across multiple projects under development and, as such, the costs are separately classified as other research and development expenses in the table below:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
|
|
|
|
2024 |
|
|
2023 |
|
|
Change |
|
PD |
|
$ |
2,666,108 |
|
|
$ |
2,493,338 |
|
|
$ |
172,770 |
|
MSA |
|
|
50,953 |
|
|
|
104,106 |
|
|
|
(53,153 |
) |
CML |
|
|
44,403 |
|
|
|
1,493,957 |
|
|
|
(1,449,554 |
) |
Other research and development expenses |
|
|
314,366 |
|
|
|
444,297 |
|
|
|
(129,931 |
) |
Total research and development expenses |
|
$ |
3,075,830 |
|
|
$ |
4,535,698 |
|
|
|
(1,459,868 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
|
|
|
2024 |
|
|
2023 |
|
|
Change |
|
PD |
|
$ |
5,010,004 |
|
|
$ |
4,250,785 |
|
|
$ |
759,219 |
|
MSA |
|
|
94,305 |
|
|
|
179,406 |
|
|
|
(85,101 |
) |
CML |
|
|
124,623 |
|
|
|
2,312,003 |
|
|
|
(2,187,380 |
) |
Other research and development expenses |
|
|
598,177 |
|
|
|
647,623 |
|
|
|
(49,446 |
) |
Total research and development expenses |
|
$ |
5,827,109 |
|
|
$ |
7,389,817 |
|
|
|
(1,562,708 |
) |
Selling, General and Administrative
Selling, general and administrative expenses include personnel related expenses, such as salaries, benefits, travel and non-cash stock-based compensation expense, expenses for outside professional services and allocated expenses. Outside professional services consist of legal, accounting and audit services, investor relations services and other consulting fees. Allocated expenses consist of rent expenses related to our offices in Lexington, Massachusetts and Atlanta, Georgia not otherwise included in research and development expenses.
We are incurring additional expenses as compared to when we were a private company, including expenses related to compliance with the rules and regulations of the SEC and those of Nasdaq, additional insurance expenses, investor relations activities and other administrative and professional services. We also are increasing our administrative headcount as a public company and as we advance our product candidates through clinical development, which will also likely require us to increase our selling, general and administrative expenses.
Results of Operations
Comparison of the Three Months Ended June 30, 2024 and 2023.
The following table sets forth the significant components of our results of operations:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
Change |
|
|
|
2024 |
|
|
2023 |
|
|
($) |
|
|
(%) |
|
|
|
(unaudited) |
|
|
|
|
|
|
|
Grant revenue |
|
$ |
— |
|
|
$ |
116,410 |
|
|
$ |
(116,410 |
) |
|
|
(100.0 |
) |
Research and development |
|
|
(3,075,830 |
) |
|
|
(4,535,698 |
) |
|
|
1,459,868 |
|
|
|
(32.2 |
) |
Selling, general and administrative |
|
|
(1,974,705 |
) |
|
|
(1,783,113 |
) |
|
|
(191,592 |
) |
|
|
10.7 |
|
Loss from operations |
|
|
(5,050,535 |
) |
|
|
(6,202,401 |
) |
|
|
1,151,866 |
|
|
|
18.6 |
|
Interest income |
|
|
90,927 |
|
|
|
424,435 |
|
|
|
(333,508 |
) |
|
|
(78.6 |
) |
Net loss |
|
$ |
(4,959,608 |
) |
|
$ |
(5,777,966 |
) |
|
$ |
818,358 |
|
|
|
14.2 |
|
Grant Revenue
Grant revenue for the three months ended June 30, 2024, decreased by $116,410 or 100.0% to $0 from $116,410 in the prior comparable period. During 2024, the Company continued to advance its Phase I and II clinical trials which were not submitted for grant revenue.
Research and Development
Research and development expenses decreased by $1,459,868 or 32.2% to $3,075,830 from $4,535,698 in the prior comparable period. The $1.5 million decrease in research and development expenses was due to a decrease of $1.4 million in IkT-001 Pro expenses due to the completion of the three-part dose finding/dose equivalence study in 2023 and a net decrease of $0.1 million in other research and development expenses.
Selling, General and Administrative
Selling, general and administrative expenses increased by $191,592 or 10.7% to $1,974,705 from $1,783,113 in the prior comparable period. The $0.2 million increase was primarily driven by a $0.4 million increase in legal and consulting fees partially offset by a $0.1 million decrease in D&O insurance and a $0.1 million net decrease in all other normal selling, general and administrative expenses.
Interest Income
Interest income decreased by $333,508 or 78.6% to $90,927 from $424,435 in the prior comparable period. The decrease was driven by a reduction in interest earned on U.S. Treasuries and money market instruments.
Comparison of the Six Months Ended June 30, 2024 and 2023.
The following table sets forth the significant components of our results of operations:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Six Months Ended June 30, |
|
|
Change |
|
|
|
2024 |
|
|
2023 |
|
|
($) |
|
|
(%) |
|
|
|
(unaudited) |
|
|
|
|
|
|
|
Grant revenue |
|
$ |
— |
|
|
$ |
180,931 |
|
|
$ |
(180,931 |
) |
|
|
(100.0 |
) |
Research and development |
|
|
(5,827,109 |
) |
|
|
(7,389,817 |
) |
|
|
1,562,708 |
|
|
|
(21.1 |
) |
Selling, general and administrative |
|
|
(4,005,786 |
) |
|
|
(3,708,464 |
) |
|
|
(297,322 |
) |
|
|
8.0 |
|
Loss from operations |
|
|
(9,832,895 |
) |
|
|
(10,917,350 |
) |
|
|
1,084,455 |
|
|
|
(9.9 |
) |
Interest income |
|
|
223,652 |
|
|
|
661,606 |
|
|
|
(437,954 |
) |
|
|
(66.2 |
) |
Net loss |
|
$ |
(9,609,243 |
) |
|
$ |
(10,255,744 |
) |
|
$ |
646,501 |
|
|
|
(6.3 |
) |
Grant Revenue
Grant revenue for the six months ended June 30, 2024, decreased by $180,931 or 100% to $0 from $180,931 in the prior comparable period. During 2024, the Company continued to advance its Phase I and Phase II clinical trials which were not submitted for grant revenue.
Research and Development
Research and development expenses decreased by $1,562,708 or 21.1% to $5,827,109 from $7,389,817 in the prior comparable period. The $1,562,708 decrease in research and development expenses was due to a decrease of $2.2 million in IkT-001 Pro expenses due to the completion of the three-part dose finding/dose equivalence study in 2023 partially offset by $0.8 million increase in Risvodetinib (IkT-148009) expenses and a net decrease of $0.2 million in other research and development expenses.
Selling, General and Administrative
Selling, general and administrative expenses increased by $297,322 or 8% to 4,005,786 from $3,708,464 in the prior comparable period. The $297,322 increase was primarily driven by a $0.5 million increase in legal and consulting fees partially offset by a $0.2 million decrease in D&O insurance, a $0.1 million decrease in investor relations costs and a $0.1 million net increase in all other normal selling, general and administrative expenses.
Interest Income
Interest income decreased by $437,954 or 66.2% to $223,652 from $661,606 in the prior comparable period. The decrease was driven by a reduction in interest earned on U.S. Treasuries and money market instruments.
Liquidity and Capital Resources
Sources of Liquidity
From our inception up until our December 2020 IPO, we funded our operations primarily through private, state and federal contracts and grants. From our inception through June 30, 2024, we generated aggregate cash proceeds of approximately $23.6 million from private, state and federal contracts and grants. In December 2020, June 2021, January 2023, and May 2024, the Company raised approximately $14.6 million, $41.1 million, $8.5 million, and $3.2 million respectively, in net proceeds from its 2020 IPO, its June 2021 Offering, its January 2023 Offering, and its May 2024 Offering, respectively.
On February 1, 2024, the Company entered into an ATM with H.C. Wainwright & Co., LLC as sales agent (the “Agent”), pursuant to which the Company may, from time to time, issue and sell shares of its Common Stock, in an aggregate offering price of up to $5.7 million through the Agent. Under the terms of the ATM, the Agent may sell the shares of Common Stock at market prices by any method that is deemed to be an “at the market offering” as defined in Rule 415 under the Securities Act. On May 20, 2024, the Company reduced the aggregate offering price to $50,000, not including the shares of common stock previously sold. As of June 30, 2024, 315,338 Shares have been sold under the Agreement with net proceeds of $820,509 to the Company.
At June 30, 2024, the Company had working capital of $4,898,258, an accumulated deficit of $76,509,968, cash and cash equivalents of $3,086,455, marketable securities of $4,853,559 and accounts payable, accrued expenses and other current liabilities of $3,375,063.
Future Funding Requirements
To date, we have not generated any revenue from the sale of commercial products. We do not expect to generate any significant revenue from product sales unless and until we obtain regulatory approval of and successfully commercialize any of our product candidates and we do not know when, or if, this will occur. We expect to continue to incur significant losses for the foreseeable future, and we expect the losses to increase as we continue the development of, and seek regulatory approvals for, our product candidates, and begin to commercialize any future approved products. We are subject to all of the risks typically related to the development of new product candidates, and we may encounter unforeseen expenses, difficulties, complications, delays and other unknown factors that may adversely affect our business. Moreover, following the completion of the December 2020 IPO, we incurred additional costs associated with operating as a public company. We anticipate that we will need substantial additional funding in connection with our continuing operations.
Until we can generate a sufficient amount of revenue from the commercialization of our product candidates, if ever, we expect to finance our incremental cash needs through a combination of equity offerings, debt financings, working capital lines of credit, grant funding and potential licenses and collaboration agreements. Additional working capital may not be available on commercially reasonable terms, if at all. If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us, we may have to significantly delay, reduce or discontinue the development or commercialization of one or more of our product candidates. If we raise additional funds through the issuance of additional debt or equity securities, it could result in dilution to our existing stockholders, increased fixed payment obligations and the existence of securities with rights that may be senior to those of our common stock. If we incur indebtedness, we could become subject to covenants that would restrict our operations and potentially impair our competitiveness, such as limitations on our ability to incur additional debt, limitations on our ability to acquire, sell or license intellectual property rights and other operating restrictions that could adversely impact our ability to conduct our business. Additionally, any future collaborations we enter into with third parties may provide capital in the near term but limit our potential cash flow and revenue in the future. Any of the foregoing could have a material adverse effect on our business, financial condition and results of operations.
Since our inception, we have incurred significant losses and negative cash flows from operations. We have an accumulated deficit of $76,509,968 at June 30, 2024. We expect to incur substantial additional losses in the future as we conduct and expand our research and development activities.
We may seek to fund our operations through public equity or private equity or debt financings, as well as other sources. However, we may be unable to raise additional working capital, or if we are able to raise additional working capital, we may be unable to do so on commercially favorable terms. Our failure to raise capital or enter into such other arrangements if and when needed would have a negative impact on our business, results of operations and financial condition and our ability to continue to develop our product candidates.
The Company had working capital of $4,898,258 at June 30, 2024. The Company intends to raise additional working capital in order to carry on its operations and current clinical trials. However, as certain elements of the Company’s operating plan are outside of the Company’s control, including the receipt of anticipated future grants and funding from a future capital raise, they cannot be considered probable. If the Company does not receive additional working capital from future anticipated grants and future anticipated capital raises, its operating plan will be limited in scope to operating at its pre-IPO levels which were limited to basic research and development but excluded current and planned future clinical trials.
We have identified conditions and events that raise doubt about our ability to continue as a going concern and our independent registered public accounting firm has included an explanatory paragraph relating to our ability to continue as a going concern in its report on our audited financial statements for the years ended December 31, 2023 and 2022 included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023. These conditions raise substantial doubt regarding our ability to continue as a going concern for a period of one year after the date the financial statements included in this Report are issued. Our management’s plans to alleviate the conditions that raise substantial doubt may include suspending or delaying certain research projects and capital expenditures and eliminating certain future operating expenses in order to fund operations at reduced levels for us to continue as a going concern for a period of 12 months from the date the financial statements are issued.
We believe that our existing cash resources as of June 30, 2024 will enable us to fund our operating requirements into December, 2024. However, we have based these estimates on assumptions that may prove to be wrong, and we could deplete our working capital sooner than planned.
The timing and amount of our operating expenditures will depend largely on:
•the timing and progress of preclinical and clinical development activities;
•the number and scope of preclinical and clinical programs we decide to pursue;
•possible delays or interruptions to preclinical studies, clinical trials, our receipt of services from our third-party service providers on whom we rely;
•the progress of the development efforts of third parties with whom we have entered into license and collaboration agreements;
•our ability to maintain our current research and development programs and to establish new research and development, license or collaboration arrangements;
•our ability and success in securing manufacturing relationships with third parties or, in the future, in establishing and operating a manufacturing facility;
•the costs involved in prosecuting, defending and enforcing patent claims and other intellectual property claims;
•the cost and timing of regulatory approvals;
•our efforts to enhance operational, financial and information management systems and hire additional personnel, including personnel to support development of our product candidates; and
•the costs and ongoing investments to in-license and/or acquire additional technologies.
A change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly change the costs and timing associated with the development of that product candidate. Furthermore, our operating plans may change in the future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans.
Cash Flows
The following table sets forth a summary of the primary sources and uses of cash for each of the periods presented below:
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Net cash used in operating activities |
|
$ |
(8,921,392 |
) |
|
$ |
(10,537,519 |
) |
|
|
|
|
|
|
|
Net cash used in investing activities |
|
|
(768,587 |
) |
|
|
(3,288,963 |
) |
|
|
|
|
|
|
|
Net cash provided by financing activities |
|
|
3,611,255 |
|
|
|
8,543,037 |
|
Net decrease in cash and cash equivalents |
|
$ |
(6,078,724 |
) |
|
$ |
(5,283,445 |
) |
Net Cash Flows Used in Operating Activities
Net cash flows used in operating activities for the six months ended June 30, 2024 , totaled $8,921,392, and consisted primarily of a net loss of $9.6 million adjusted for non-cash stock compensation of $0.1 million, a decrease in prepaid research and development of $0.1 million, an increase in accounts payable of $0.9 million, and a decrease in accrued expenses and other current liabilities of $0.2 million.
Net cash flows used in operating activities for the six months ended June 30, 2023, totaled $10,537,519, and consisted primarily of a net loss of $10.3 million adjusted for non-cash stock compensation of $0.2 million, depreciation and lease expense of $0.2 million, a decrease in accounts receivable of $39,721, decrease in prepaid expenses and other assets of $0.4 million, an increase in prepaid research and development of $0.7 million, decrease in accounts payable of $0.4 million, and a decrease in accrued expenses and other current liabilities of $0.6 million.
Cash Used in Investing Activities
Net cash flows used in investing activities for the six months ended June 30, 2024, totaled $768,587, of which $9.2 million was used for the purchase of marketable securities investments and $8.4 million was provided by maturity of marketable securities.
Net cash flows used in investing activities for the six months ended June 30, 2023, totaled $3,288,963, of which $18.7 million was used for the purchase of marketable securities investments and $15.4 million was provided by maturity of marketable securities.
Cash Provided by Financing Activities
Net cash flows provided by financing activities for the six months ended June 30, 2024, totaled $3,611,255, which consisted of net proceeds from issuance of common stock and pre-funded warrants in with connection our May 2024 Offering and our ATM Offering.
Net cash flows provided by financing activities for the six months ended June 30, 2023, totaled $8,543,037, consisted of net proceeds from issuance of common stock and pre-funded warrants in connection with our January 2023 Offering.
Off-Balance Sheet Arrangements
We have not entered into any off-balance sheet arrangements.
Contractual Obligations and Commitments
On April 18, 2022, the Company entered into an operating lease agreement through September 30, 2025 for its office space in Lexington, Massachusetts. The Lexington lease contains escalating payments during the lease period. Upon execution of this lease agreement, the Company prepaid one month of rent, applied to the first month's rent, and a security deposit, which will be held in escrow and credited at the termination of the lease. Our total lease obligation is $190,546, consisting of minimum annual rental obligations of $75,580 for fiscal year 2024 and $114,966 for fiscal year 2025.
Critical Accounting Policies and Significant Judgments and Estimates
This discussion and analysis of our financial condition and results of operations is based on our unaudited condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States, or US GAAP. The preparation of these unaudited condensed consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the unaudited condensed consolidated financial statements, as well as the reported expenses incurred during the reporting periods. Our estimates are based on our historical experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. While our significant accounting policies are described in more detail in the notes to our unaudited condensed consolidated financial statements included elsewhere in this Report, we believe that the following accounting policies are critical to understanding our historical and future performance, as these policies relate to the more significant areas involving management’s judgments and estimates.
Research and Development Expenses
We record research and development expenses to operations as incurred. Research and development expenses represent costs incurred by us for the discovery and development of our product candidates and the development of our RAMP drug discovery program and prodrug technologies and include: employee-related expenses, such as salaries, benefits, travel and non-cash stock-based compensation expense; external research and development expenses incurred under arrangements with third parties, such as CROs, preclinical testing organizations, clinical testing organizations, CMOs, academic and non-profit institutions and consultants; costs to acquire technologies to be used in research and development that have not reached technological feasibility and have no alternative future use; license fees; and other expenses, which include direct and allocated expenses for laboratory, facilities and other costs.
As part of the process of preparing financial statements, we are required to estimate and accrue expenses. A portion of our research and development expenses is comprised of external costs, which we track on a program-specific basis. We record the estimated expenses of research and development activities conducted by third-party service providers as they are incurred and provided within research and development expense in the condensed consolidated statements of operations and comprehensive loss. These services include the conduct of clinical studies, preclinical studies and consulting services. These costs are a significant component of our research and development expenses.
Costs for research and development activities are recognized based on costs incurred. We make significant judgments and estimates in determining the accrued balance in each reporting period. As actual costs become known, we adjust our accrued estimates. Although we do not expect our estimates to be materially different from amounts actually incurred, our understanding of the status and timing of services performed may vary from our estimates and could result in us reporting amounts that are too high or too low in any particular period. Our accrued expenses are dependent, in part, upon the receipt of timely and accurate reporting from
external clinical research organizations and other third-party service providers. Due to the nature of estimates, we cannot assure you that we will not make changes to our estimates in the future as we become aware of additional information about the status or conduct of our clinical trials and other research activities.
Item 3. Quantitative and Qualitative Disclosures About Market Risk.
As a smaller reporting company, we are not required to provide disclosure regarding quantitative and qualitative market risk.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
Under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, we evaluated the effectiveness of the design and operation of our disclosure controls and procedures pursuant to Rule 13a-15(b) and 15d-15(b) under the Exchange Act as of the end of the period covered by this Report. Our disclosure controls and procedures are designed to ensure that information required to be disclosed in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including the Chief Executive Officer and the Chief Financial Officer, to allow timely decisions regarding required disclosures. Any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objective and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on that evaluation, our Chief Executive Officer and Chief Financial Officer have concluded that, because of a material weakness in our internal controls over financial reporting, our disclosure controls and procedures were not effective at a reasonable assurance level as of June 30, 2024 and at December 31, 2023. The material weakness related to a non-routine transaction associated with the exclusion of pre-funded warrants in the weighted-average number of common shares used in the calculation of net loss per share.
In response to the material weakness described above, during the quarter ended June 30, 2024, we have strengthened internal controls to ensure all aspects of accounting treatment and disclosure are evaluated as part of non-routine accounting transactions.
Changes in Internal Control over Financial Reporting
Other than as described above, there were no changes in our internal control over financial reporting or in any other factors that could significantly affect these controls during the three and six months ended June 30, 2024 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
On April 26, 2024, the Company received a notice of a demand for arbitration with the American Arbitration Association from Pivot Holding LLC (“Pivot”), that alleges to be a successor in interest to Sphaera Pharma Pte. Ltd. (“Sphaera”), in connection with the Collaborative Research and Development Agreement dated February 29, 2012, as amended, between the Company and Sphaera (the "Agreement"). Pivot alleges breach of contract by the Company for failure to pay milestone payments and seeks damages of $1.625 million in milestone payments plus interest. The Company believes that Pivot’s claims are without merit and that the Company hasn’t owed and doesn’t owe any milestone payments to Pivot. The Company intends to vigorously dispute Pivot’s claims. The parties have agreed to mediate before arbitrating and a mediation is scheduled for September 6, 2024.
On June 17, 2024, the Company filed an answering statement and counterclaim, in which the Company disputed Pivot’s claims and counterclaimed that Sphaera had breached the Agreement by failing to complete properly the drug development work required by the Agreement, causing the Company over $900,000 in damages.
Item 1A. Risk Factors.
In addition to the other information set forth in this report, you should carefully consider the factors discussed in “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2023. Other than as set forth below, there have been no material changes from the risk factors previously disclosed in our Annual Report on Form 10-K for the year ended December 31, 2023.
We have identified a material weakness in our internal control over financial reporting, as of June 30, 2024, which if not remediated, could adversely affect our business.
During the quarter ended June 30, 2024, we identified a material weakness in our internal control over financial reporting. We identified an error in management's conclusions regarding a certain non-routine transaction. Specifically, we did not appropriately include pre-funded warrants in our net loss per share calculation.
Our management is responsible for establishing and maintaining adequate internal control over financial reporting to provide reasonable assurance regarding the reliability of our financial reporting and the preparation of financial statements for external purposes in accordance with U.S. generally accepted accounting principles. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. We determined that our internal control over financial reporting and disclosure controls and procedures were not effective as a result of the material weakness related to an immaterial error in the determination of the weighted-average number of common shares used in the calculation of net loss per share in the previously reported Condensed Consolidated Financial Statements, as discussed in Part I, Item 4 of this Form 10-Q.
A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of a company’s annual or interim financial statements will not be prevented or detected on a timely basis.
As such, if we do not remediate this material weakness in a timely manner, or if additional material weaknesses in our internal control over financial reporting are discovered, they may adversely affect our ability to record, process, summarize and report financial information timely and accurately and our financial statements may contain material misstatements or omissions. Additionally, our internal control environment and remediation efforts do not provide absolute assurance with regard to timely detecting or preventing control deficiencies and thus do not insulate us from any failure to meet our financial reporting obligations.
It is possible that additional control deficiencies could be identified by our management or by our independent registered public accounting firm in the future or may occur without being identified. Such a failure could require us to incur the expense of remediation, result in regulatory scrutiny, investigations or enforcement actions, cause investors to lose confidence in our reported financial condition and have a negative effect on the trading price of our common stock, lead to a default under our indebtedness, and otherwise have a material adverse effect on our business, financial condition, results of operations, and cash flows.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
None.
Item 6. Exhibits.
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Incorporated by Reference to SEC Filing |
Exhibit No. |
|
Filed Exhibit Description |
|
Form |
|
Exhibit No. |
|
File No. |
|
Date Filed |
3.1 |
|
Amended and Restated Certificate of Incorporation of Inhibikase Therapeutics, Inc., as most recently amended and restated effective Wednesday, December 23, 2020. |
|
8-K |
|
3.1 |
|
001-39676 |
|
12/29/2020 |
3.2 |
|
Certificate of Amendment to Amended and Restated Certificate of Incorporation of Inhibikase Therapeutics, Inc. |
|
8-K |
|
3.1 |
|
001-39676 |
|
06/29/2023 |
3.3 |
|
Amended and Restated Bylaws of Inhibikase Therapeutics, Inc. |
|
8-K |
|
3.3 |
|
001-39676 |
|
12/29/2020 |
4.1 |
|
Form of Pre-Funded Warrant (May 2024) |
|
8-K |
|
4.1 |
|
001-39676 |
|
05/20/2024 |
4.2 |
|
Form of Series A Warrant (May 2024) |
|
8-K |
|
4.2 |
|
001-39676 |
|
05/20/2024 |
4.3 |
|
Form of Series B Warrant (May 2024) |
|
8-K |
|
4.3 |
|
001-39676 |
|
05/20/2024 |
4.4 |
|
Form of Series C Warrant (May 2024) |
|
8-K |
|
4.4 |
|
001-39676 |
|
05/20/2024 |
4.5 |
|
Form of Series D Warrant (May 2024) |
|
8-K |
|
4.5 |
|
001-39676 |
|
05/20/2024 |
4.6 |
|
Form of Warrant Amendment (May 2024) |
|
8-K |
|
4.6 |
|
001-39676 |
|
05/20/2024 |
10.1 |
|
Employment Agreement between Inhibikase Therapeutics, Inc. and Garth Lees-Rolfe, dated as of April 1, 2024 |
|
S-1 |
|
10.18 |
|
333-278844 |
|
04/19/2024 |
10.2 |
|
Securities Purchase Agreement, dated as of May 20, 2024 |
|
8-K |
|
10.1 |
|
001-39676 |
|
05/20/2024 |
10.3 |
|
Placement Agency Agreement, dated as of May 20, 2024 |
|
8-K |
|
10.2 |
|
001-39676 |
|
05/20/2024 |
10.4 |
|
Inducement Letter, dated as of May 20, 2024 |
|
8-K |
|
10.3 |
|
001-39676 |
|
05/20/2024 |
31.1* |
|
Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
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|
|
|
|
|
|
|
31.2* |
|
Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
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|
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32.1** |
|
Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
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32.2** |
|
Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
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101.INS |
|
Inline XBRL Instance Document |
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|
101.SCH |
|
Inline XBRL Taxonomy Extension Schema Document |
|
|
|
|
|
|
|
|
101.CAL |
|
Inline XBRL Taxonomy Extension Calculation Linkbase Document |
|
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|
101.DEF |
|
Inline XBRL Taxonomy Extension Definition Linkbase Document |
|
|
|
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|
|
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|
101.LAB |
|
Inline XBRL Taxonomy Extension Label Linkbase Document |
|
|
|
|
|
|
|
|
101.PRE |
|
Inline XBRL Taxonomy Extension Presentation Linkbase Document |
|
|
|
|
|
|
|
|
104 |
|
Cover Page Interactive Data File (formatted as inline XBRL with applicable taxonomy extension information contained in Exhibits 101) |
|
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|
|
|
|
|
* Filed herewith.
** Furnished herewith.
# A contract, compensatory plan or arrangement to which a director or executive officers is a party or in which one or more directors or executive officers are eligible to participate.
Exhibits 32.1 and 32.2 are being furnished and shall not be deemed to be “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall such exhibits be deemed to be incorporated by reference in any
registration statement or other document filed under the Securities Act or the Exchange Act, except as otherwise stated in any such filing.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
|
|
|
|
|
|
Inhibikase Therapeutics, Inc. |
|
|
|
|
Date: August 14, 2024 |
|
By: |
/s/ MILTON H. WERNER, Ph.D. |
|
|
|
Milton H. Werner, Ph.D. |
|
|
|
Chief Executive Officer (Principal Executive Officer) |
|
|
|
|
Date: August 14, 2024 |
|
By: |
/s/ GARTH LEES-ROLFE |
|
|
|
Garth Lees-Rolfe |
|
|
|
Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) |
EXHIBIT 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Milton H. Werner, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Inhibikase Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
|
/s/ Milton H. Werner |
Milton H. Werner, Ph.D. |
President and Chief Executive Officer (Principal Executive Officer) |
Date: August 14, 2024
EXHIBIT 31.2
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Garth Lees-Rolfe, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Inhibikase Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
|
/s/ Garth Lees-Rolfe |
Garth Lees-Rolfe |
Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) |
Date: August 14, 2024
EXHIBIT 32.1
CERTIFICATION OF
PRINCIPAL EXECUTIVE OFFICER
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report on Form 10-Q of Inhibikase Therapeutics, Inc. (the “Company”) for the period ended June 30, 2024 (the “Report”), the undersigned hereby certifies in his capacity as President and Chief Executive Officer of the Company pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:
1. the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and
2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
|
|
|
|
Dated: August 14, 2024 |
|
By: |
/s/ Milton H. Werner |
|
|
|
Milton H. Werner, Ph.D. |
|
|
|
President and Chief Executive Officer |
|
|
|
(Principal Executive Officer) |
EXHIBIT 32.2
CERTIFICATION OF
PRINCIPAL FINANCIAL OFFICER
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report on Form 10-Q of Inhibikase Therapeutics, Inc. (the “Company”) for the period ended June 30, 2024 (the “Report”), the undersigned hereby certifies in his capacity as Chief Financial Officer of the Company pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:
1. the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and
2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
|
|
|
|
Dated: August 14, 2024 |
|
By: |
/s/ Garth Lees-Rolfe |
|
|
|
Garth Lees-Rolfe |
|
|
|
Chief Financial Officer |
|
|
|
(Principal Financial Officer and Principal Accounting Officer) |
v3.24.2.u1
Document and Entity Information - shares
|
6 Months Ended |
|
Jun. 30, 2024 |
Aug. 01, 2024 |
Cover [Abstract] |
|
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Document Type |
10-Q
|
|
Amendment Flag |
false
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Document Quarterly Report |
true
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false
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|
Document Period End Date |
Jun. 30, 2024
|
|
Document Fiscal Year Focus |
2024
|
|
Document Fiscal Period Focus |
Q2
|
|
Current Fiscal Year End Date |
--12-31
|
|
Entity Registrant Name |
INHIBIKASE THERAPEUTICS, INC.
|
|
Entity Central Index Key |
0001750149
|
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Entity Filer Category |
Non-accelerated Filer
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Entity Shell Company |
false
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Entity Small Business |
true
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Entity Emerging Growth Company |
true
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Entity Ex Transition Period |
false
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Entity File Number |
001-39676
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Entity Interactive Data Current |
Yes
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Entity Current Reporting Status |
Yes
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Entity Tax Identification Number |
26-3407249
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Entity Incorporation, State or Country Code |
DE
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Entity Address, Address Line One |
3350 Riverwood Parkway SE
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Entity Address, Address Line Two |
Suite 1900
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Entity Address, City or Town |
Atlanta
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Entity Address, State or Province |
GA
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|
Entity Address, Postal Zip Code |
30339
|
|
City Area Code |
678
|
|
Local Phone Number |
392-3419
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Title of 12(b) Security |
Common Stock, $0.001 par value
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Trading Symbol |
IKT
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NASDAQ
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v3.24.2.u1
Condensed Balance Sheets - USD ($)
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Current assets: |
|
|
Cash and cash equivalents |
$ 3,086,455
|
$ 9,165,179
|
Marketable securities |
4,853,559
|
4,086,873
|
Prepaid research and development |
306,300
|
219,817
|
Prepaid expenses and other current assets |
356,487
|
739,179
|
Total current assets |
8,602,801
|
14,211,048
|
Equipment and improvements, net |
60,235
|
73,372
|
Right-of-use asset |
163,762
|
222,227
|
Total assets |
8,826,798
|
14,506,647
|
Current liabilities: |
|
|
Accounts payable |
1,340,538
|
646,767
|
Lease obligation, current |
152,224
|
150,095
|
Accrued expenses and other current liabilities |
2,034,525
|
2,259,955
|
Insurance premium financing payable |
177,256
|
381,784
|
Total current liabilities |
3,704,543
|
3,438,601
|
Lease obligation, net of current portion |
25,606
|
90,124
|
Total liabilities |
3,730,149
|
3,528,725
|
Commitments and contingencies (see Note 13) |
|
|
Stockholders’ equity: |
|
|
Preferred stock, $0.001 par value; 10,000,000 shares authorized; 0 shares issued and outstanding at June 30, 2024 and December 31, 2023 |
0
|
0
|
Common stock, $0.001 par value; 100,000,000 shares authorized; 7,216,145 and 6,186,280 shares issued and outstanding at June 30, 2024 and December 31, 2023 |
7,216
|
6,186
|
Additional paid-in capital |
81,600,425
|
77,871,584
|
Accumulated other comprehensive (loss) income |
(1,024)
|
877
|
Accumulated deficit |
(76,509,968)
|
(66,900,725)
|
Total stockholders' equity |
5,096,649
|
10,977,922
|
Total liabilities and stockholders' equity |
$ 8,826,798
|
$ 14,506,647
|
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v3.24.2.u1
Condensed Balance Sheets (Parenthetical) - $ / shares
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock, par value |
$ 0.001
|
$ 0.001
|
Preferred stock, shares authorized |
10,000,000
|
10,000,000
|
Preferred stock, shares issued |
0
|
0
|
Preferred stock, shares outstanding |
0
|
0
|
Common stock, par value |
$ 0.001
|
$ 0.001
|
Common stock, shares authorized |
100,000,000
|
100,000,000
|
Common stock, shares issued |
7,216,145
|
6,186,280
|
Common stock, shares outstanding |
7,216,145
|
6,186,280
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.24.2.u1
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Revenue: |
|
|
|
|
Total revenue |
$ 0
|
|
$ 0
|
|
Revenue from Contract with Customer, Product and Service [Extensible List] |
us-gaap:GrantMember
|
us-gaap:GrantMember
|
us-gaap:GrantMember
|
us-gaap:GrantMember
|
Costs and expenses: |
|
|
|
|
Research and development |
$ 3,075,830
|
|
$ 5,827,109
|
|
Selling, general and administrative |
1,974,705
|
|
4,005,786
|
|
Total costs and expenses |
5,050,535
|
|
9,832,895
|
|
Loss from operations |
(5,050,535)
|
|
(9,832,895)
|
|
Interest income |
90,927
|
|
223,652
|
|
Net loss |
(4,959,608)
|
$ (5,777,966)
|
(9,609,243)
|
$ (10,255,744)
|
Other comprehensive income (loss), net of tax |
|
|
|
|
Unrealized gains (loss) on marketable securities |
776
|
|
(1,901)
|
|
Comprehensive loss |
$ (4,958,832)
|
|
$ (9,611,144)
|
|
Net loss per share - basic |
$ (0.66)
|
|
$ (1.38)
|
|
Net loss per share - diluted |
$ (0.66)
|
|
$ (1.38)
|
|
Weighted average number of common share basic |
7,535,667
|
|
6,939,779
|
|
Weighted average number of common share diluted |
7,535,667
|
|
6,939,779
|
|
As Adjusted |
|
|
|
|
Revenue: |
|
|
|
|
Total revenue |
|
116,410
|
|
180,931
|
Costs and expenses: |
|
|
|
|
Research and development |
|
4,535,698
|
|
7,389,817
|
Selling, general and administrative |
|
1,783,113
|
|
3,708,464
|
Total costs and expenses |
|
6,318,811
|
|
11,098,281
|
Loss from operations |
|
(6,202,401)
|
|
(10,917,350)
|
Interest income |
|
424,435
|
|
661,606
|
Net loss |
|
(5,777,966)
|
|
(10,255,744)
|
Other comprehensive income (loss), net of tax |
|
|
|
|
Unrealized gains (loss) on marketable securities |
|
(167,536)
|
|
(106,432)
|
Comprehensive loss |
|
$ (5,945,502)
|
|
$ (10,362,176)
|
Net loss per share - basic |
|
$ (0.94)
|
|
$ (1.74)
|
Net loss per share - diluted |
|
$ (0.94)
|
|
$ (1.74)
|
Weighted average number of common share basic |
|
6,162,280
|
|
5,883,895
|
Weighted average number of common share diluted |
|
6,162,280
|
|
5,883,895
|
X |
- DefinitionAmount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.
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v3.24.2.u1
Condensed Statements of Stockholders' Equity (Unaudited) - USD ($)
|
Total |
Common Stock |
Additional Paid-In Capital |
Accumulated Other Comprehensive Income (Loss) |
Accumulated Deficit |
Beginning balance at Dec. 31, 2022 |
$ 21,035,401
|
$ 4,224
|
$ 68,798,301
|
$ 104,718
|
$ (47,871,842)
|
Beginning balance, Shares at Dec. 31, 2022 |
|
4,224,294
|
|
|
|
Stock-based compensation expense |
123,273
|
|
123,273
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
8,542,942
|
$ 972
|
8,541,970
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs, Shares |
|
971,532
|
|
|
|
Other comprehensive income |
61,104
|
|
|
61,104
|
|
Net loss |
(4,477,778)
|
|
|
|
(4,477,778)
|
Ending balance at Mar. 31, 2023 |
25,284,942
|
$ 5,196
|
77,463,544
|
165,822
|
(52,349,620)
|
Ending balance, Shares at Mar. 31, 2023 |
|
5,195,826
|
|
|
|
Beginning balance at Dec. 31, 2022 |
21,035,401
|
$ 4,224
|
68,798,301
|
104,718
|
(47,871,842)
|
Beginning balance, Shares at Dec. 31, 2022 |
|
4,224,294
|
|
|
|
Net loss |
(10,255,744)
|
|
|
|
|
Ending balance at Jun. 30, 2023 |
19,464,380
|
$ 5,291
|
77,588,389
|
(1,714)
|
(58,127,586)
|
Ending balance, Shares at Jun. 30, 2023 |
|
5,290,826
|
|
|
|
Beginning balance at Dec. 31, 2022 |
21,035,401
|
$ 4,224
|
68,798,301
|
104,718
|
(47,871,842)
|
Beginning balance, Shares at Dec. 31, 2022 |
|
4,224,294
|
|
|
|
Ending balance at Dec. 31, 2023 |
$ 10,977,922
|
$ 6,186
|
77,871,584
|
877
|
(66,900,725)
|
Ending balance, Shares at Dec. 31, 2023 |
6,186,280
|
6,186,280
|
|
|
|
Beginning balance at Mar. 31, 2023 |
$ 25,284,942
|
$ 5,196
|
77,463,544
|
165,822
|
(52,349,620)
|
Beginning balance, Shares at Mar. 31, 2023 |
|
5,195,826
|
|
|
|
Stock-based compensation expense |
124,845
|
|
124,845
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
95
|
$ 95
|
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs, Shares |
|
95,000
|
|
|
|
Other comprehensive income |
(167,536)
|
|
|
(167,536)
|
|
Net loss |
(5,777,966)
|
|
|
|
(5,777,966)
|
Ending balance at Jun. 30, 2023 |
19,464,380
|
$ 5,291
|
77,588,389
|
(1,714)
|
(58,127,586)
|
Ending balance, Shares at Jun. 30, 2023 |
|
5,290,826
|
|
|
|
Beginning balance at Dec. 31, 2023 |
$ 10,977,922
|
$ 6,186
|
77,871,584
|
877
|
(66,900,725)
|
Beginning balance, Shares at Dec. 31, 2023 |
6,186,280
|
6,186,280
|
|
|
|
Stock-based compensation expense |
$ 53,434
|
|
53,434
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
397,607
|
$ 291
|
397,316
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs, Shares |
|
290,564
|
|
|
|
Other comprehensive income |
(2,677)
|
|
|
(2,677)
|
|
Net loss |
(4,649,635)
|
|
|
|
(4,649,635)
|
Ending balance at Mar. 31, 2024 |
6,776,651
|
$ 6,477
|
78,322,334
|
(1,800)
|
(71,550,360)
|
Ending balance, Shares at Mar. 31, 2024 |
|
6,476,844
|
|
|
|
Beginning balance at Dec. 31, 2023 |
$ 10,977,922
|
$ 6,186
|
77,871,584
|
877
|
(66,900,725)
|
Beginning balance, Shares at Dec. 31, 2023 |
6,186,280
|
6,186,280
|
|
|
|
Net loss |
$ (9,609,243)
|
|
|
|
|
Ending balance at Jun. 30, 2024 |
$ 5,096,649
|
$ 7,216
|
81,600,425
|
(1,024)
|
(76,509,968)
|
Ending balance, Shares at Jun. 30, 2024 |
7,216,145
|
7,216,145
|
|
|
|
Beginning balance at Mar. 31, 2024 |
$ 6,776,651
|
$ 6,477
|
78,322,334
|
(1,800)
|
(71,550,360)
|
Beginning balance, Shares at Mar. 31, 2024 |
|
6,476,844
|
|
|
|
Stock-based compensation expense |
30,697
|
|
30,697
|
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
3,248,133
|
$ 739
|
3,247,394
|
0
|
|
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs, Shares |
|
739,301
|
|
|
|
Other comprehensive income |
776
|
|
|
776
|
|
Net loss |
(4,959,608)
|
|
|
|
(4,959,608)
|
Ending balance at Jun. 30, 2024 |
$ 5,096,649
|
$ 7,216
|
$ 81,600,425
|
$ (1,024)
|
$ (76,509,968)
|
Ending balance, Shares at Jun. 30, 2024 |
7,216,145
|
7,216,145
|
|
|
|
X |
- DefinitionAmount of increase to additional paid-in capital (APIC) for recognition of cost for award under share-based payment arrangement.
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v3.24.2.u1
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
|
3 Months Ended |
6 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Mar. 31, 2024 |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Cash flows from operating activities |
|
|
|
|
|
|
|
Net loss |
$ (4,959,608)
|
$ (4,649,635)
|
$ (5,777,966)
|
$ (4,477,778)
|
$ (9,609,243)
|
$ (10,255,744)
|
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
|
Depreciation |
6,569
|
|
159,204
|
|
13,137
|
164,247
|
|
Stock-based compensation expense |
|
|
|
|
84,131
|
248,118
|
|
Changes in operating assets and liabilities: |
|
|
|
|
|
|
|
Accounts receivable |
|
|
|
|
0
|
(39,721)
|
|
Operating lease right-of-use assets |
|
|
|
|
58,465
|
51,551
|
|
Prepaid expenses and other current assets |
|
|
|
|
30,719
|
(380,471)
|
|
Prepaid research and development |
|
|
|
|
(86,483)
|
692,387
|
|
Accounts payable |
|
|
|
|
875,701
|
(397,027)
|
|
Operating lease liabilities |
|
|
|
|
(62,389)
|
(53,350)
|
|
Accrued expenses and other current liabilities |
|
|
|
|
(225,430)
|
(567,509)
|
|
Net cash used in operating activities |
|
|
|
|
(8,921,392)
|
(10,537,519)
|
|
Cash flows from investing activities |
|
|
|
|
|
|
|
Purchases of equipment and improvements |
|
|
|
|
0
|
(14,238)
|
|
Purchases of investments - marketable securities |
|
|
|
|
(9,209,545)
|
(18,681,260)
|
|
Maturities of investments - marketable securities |
|
|
|
|
8,440,958
|
15,406,535
|
|
Net cash used in investing activities |
|
|
|
|
(768,587)
|
(3,288,963)
|
|
Cash flows from financing activities |
|
|
|
|
|
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
|
1,000,000
|
3,611,255
|
8,543,037
|
|
Net cash provided by financing activities |
|
|
|
|
3,611,255
|
8,543,037
|
|
Net decrease in cash and cash equivalents |
|
|
|
|
(6,078,724)
|
(5,283,445)
|
|
Cash and cash equivalents at beginning of period |
|
$ 9,165,179
|
|
$ 7,188,553
|
9,165,179
|
7,188,553
|
$ 7,188,553
|
Cash and cash equivalents at end of period |
$ 3,086,455
|
|
$ 1,905,108
|
|
3,086,455
|
1,905,108
|
$ 9,165,179
|
Supplemental disclosures of non-cash financing activities |
|
|
|
|
|
|
|
Non-cash financing costs |
|
|
|
|
(181,930)
|
0
|
|
Supplemental disclosures of cash flow information |
|
|
|
|
|
|
|
Issuance costs |
|
|
|
|
$ 1,203,350
|
$ 1,456,479
|
|
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v3.24.2.u1
Nature of Business
|
6 Months Ended |
Jun. 30, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Nature of Business |
We are a clinical-stage pharmaceutical company developing protein kinase inhibitor therapeutics to modify the course of Parkinson’s disease (“PD”), Parkinson’s-related disorders and other diseases of the Abelson Tyrosine Kinases. The Company’s multi-therapeutic pipeline has a primary focus on neurodegeneration and its lead program utilizing Risvodetinib (also known as IkT-148009), a selective inhibitor of the non-receptor Abelson Tyrosine Kinases, targets the treatment of Parkinson’s disease inside and outside the brain as well as other diseases that arise from Abelson Tyrosine Kinases. In 2021, we commenced clinical development of Risvodetinib (IkT-148009), which we believe can modify the course of Parkinson’s disease including its manifestation in the gastrointestinal tract, or GI. In January 2023, the Company initiated its Phase 2 program, termed ‘the 201 trial’ (www.the201trial.com), for Risvodetinib (IkT-148009) as a treatment for Parkinson’s disease. In June 2024, the 201 trial was fully enrolled. We are also developing platform technologies to improve delivery of protein kinase inhibitors in patients. One example of our potential ability to improve drug delivery is IkT-001Pro, a prodrug of the anticancer agent imatinib mesylate, which is intended to treat Stable Phase Chronic Myelogenous Leukemia, or SP-CML. IkT-001Pro has completed a three-part dose finding/dose equivalence study in 66 healthy volunteers (known as ‘the 501 trial’). We are also evaluating the application of IkT-001Pro to pulmonary arterial hypertension (PAH). The Company has filed an Investigational New Drug Application, or IND, with the Food and Drug Administration, or FDA. For both IkT-148009 and IkT-001Pro, we have completed clinical batch manufacturing of a film-coated tablet formulation. The bioequivalence studies with IkT-001Pro have already implemented these tablets into the study. A pharmacokinetic bridging study with two different tablet formulations of IkT-148009 was completed in 2023.
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v3.24.2.u1
Going Concern
|
6 Months Ended |
Jun. 30, 2024 |
DisclosureOfGoingConcernAbstract |
|
Going Concern |
The Company has incurred recurring losses. At June 30, 2024, the Company had working capital of $4,898,258, an accumulated deficit of $76,509,968, cash and cash equivalents of $3,086,455, marketable securities of $4,853,559 and accounts payable and accrued expenses of $3,375,063. The future success of the Company is dependent on its ability to successfully obtain additional working capital, obtain regulatory approval for and successfully launch and commercialize its product candidates and to ultimately attain profitable operations. Historically, the Company has funded its operations primarily through cash received in connection with revenue from its various grant programs. In addition, in December 2020, June 2021, January 2023 and May 2024, the Company raised approximately $14.6 million, $41.1 million, $8.5 million and $3.2 million in net proceeds for working capital from its initial public offering (“IPO”), June 2021 Offering, January 2023 Offering and May 2024 Offering, respectively. The Company is subject to a variety of risks similar to other early-stage life science companies including, but not limited to, the successful development, regulatory approval, and market acceptance of the Company’s product candidates, development by its competitors of new technological innovations, protection of proprietary technology, and raising additional working capital. The Company has incurred significant research and development expenses, general and administrative expenses related to its product candidate programs and negative cash flows from operations. The Company anticipates costs and expenses to increase in the future as the Company continues to develop its product candidates. The Company may seek to fund its operations through additional public equity, private equity, or debt financings, as well as other sources. However, the Company may be unable to raise additional working capital, or if it is able to raise additional capital, it may be unable to do so on commercially favorable terms. The Company’s failure to raise capital or enter into such other arrangements if and when needed would have a negative impact on the Company’s business, results of operations and financial condition and the Company’s ability to continue to develop its product candidates. The Company estimates that its working capital at June 30, 2024, including the funds raised from the May 2024 Offering is sufficient to fund its normal operations into December, 2024. These conditions raise substantial doubt regarding the Company’s ability to continue as a going concern for a period of one year after the date the financial statements are issued. Management’s plan to alleviate the conditions that raise substantial doubt may include additional equity raises, suspending or delaying certain research projects and capital expenditures and eliminating certain future operating expenses in order to fund operations at reduced levels for the Company to continue as a going concern. The accompanying condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and satisfaction of liabilities in the ordinary course of business. The condensed consolidated financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities that might result from the outcome of the uncertainties described above.
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v3.24.2.u1
Basis of Presentation and Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Basis of Presentation and Significant Accounting Policies |
3.Basis of Presentation and Significant Accounting Policies Basis of Presentation of Interim Financial Statements The accompanying unaudited condensed consolidated financial statements were prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim financial statements and, in the opinion of management, include all normal and recurring adjustments necessary to present fairly the results of the interim periods shown. The December 31, 2023 balance sheet was derived from December 31, 2023 audited financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles (“US GAAP”) have been condensed or omitted pursuant to such SEC rules and regulations. Management believes that the disclosures made are adequate to make the information presented not misleading. The results for the interim periods are not necessarily indicative of results to be expected for the fiscal year ending December 31, 2024. The unaudited condensed consolidated financial statements contained herein should be read in conjunction with the Company’s annual audited financial statements and notes thereto for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC. The unaudited condensed consolidated financial statements have been prepared in conformity with US GAAP, which prescribes elimination of all significant intercompany accounts and transactions in the accounts of the Company and its wholly-owned subsidiary, IKT Securities Corporation, Inc., which was incorporated in the Commonwealth of Massachusetts in December 2021. Any reference in these notes to applicable guidance is meant to refer to the authoritative US GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Update (“ASU”) of the Financial Accounting Standards Board (“FASB”). From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies and are generally adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its financial position or results of operations upon adoption. The Company qualifies as an “emerging growth company” as defined in the Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act. The JOBS Act permits an emerging growth company such as the Company to take advantage of an extended transition period to comply with new or revised accounting standards applicable to public companies until those standards would otherwise apply to private companies. The Company has elected not to “opt out” of such extended transition period, which means that when a standard is issued or revised and it has different application dates for public or private companies, the Company will adopt the new or revised standard at the time private companies adopt the new or revised standard and will do so until such time that it either (i) irrevocably elects to “opt out” of such extended transition period or (ii) no longer qualifies as an emerging growth company. On June 30, 2023, we effected a reverse stock split at the ratio of 1 post-split share for every 6 pre-split shares. All common stock, options, warrant amounts, per share information and references have been retroactively adjusted for all figures presented to reflect this split unless specifically stated otherwise. Use of Estimates The preparation of the Company’s financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The Company utilizes certain estimates in the determination of our liquidity and working capital adequacy, the fair value of its stock options and warrants, deferred tax valuation allowances and revenue recognition, to record expenses relating to research and development contracts and accrued expenses. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from such estimates. New Accounting Pronouncements
From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies that the Company adopts as of the specified effective date. Unless otherwise discussed below, the Company does not believe that the adoption of recently issued standards have or may have a material impact on its condensed consolidated financial statements and disclosures. Concentrations of Credit Risk For the three and six months ended June 30, 2024, the Company did not report any revenues. For the three and six months ended June 30, 2023, the Company derived 100% of its total revenue from a single source, the United States Government, in the form of federal research grants. Revenue Recognition The Company generates revenue from research and development grants under contracts with third parties that do not create customer-vendor relationships. The Company’s research and development grants are non-exchange transactions and are not within the scope of ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”). Contribution revenue earned from activities performed pursuant to research and development grants is reported as grant revenue in the Company’s unaudited condensed consolidated statements of operations and comprehensive loss. Revenue from these grants is recognized as the Company incurs qualifying expenses as stipulated by the terms of the respective grant. Cash received from grants in advance of incurring qualifying expenses is recorded as deferred revenue. The Company records revenue and a corresponding receivable when qualifying costs are incurred before the grants are received. Research and Development Costs Costs incurred in the research and development of the Company’s product candidates are expensed as incurred. Research and development expenses consist of costs incurred in performing research and development activities, including activities associated with performing services under grant revenue contracts and include salaries and benefits, stock compensation, research-related subcontractors and consultants, supplies and overhead costs. Advance payments made to suppliers and contract research organizations are classified as prepaid research and development and are expensed as research and development as the supplies are consumed and the contract services are provided. During the three and six months ended June 30, 2024, the Company incurred expenses of approximately $175 thousand and $297 thousand, respectively, with a related party vendor included in research and development expenses. During the three and six months ended June 30, 2023, the Company did not incur any expenses with a related party vendor that were included in research and development expenses. As at the period ended June 30, 2024 and December 31, 2023, the Company had a payable or accrued expense balance with a related party vendor of approximately $125 thousand and $57 thousand, respectively, included in accounts payable and accrued expenses. Leases The Company accounts for its leases under ASU 2021-09, ASU 2018-10, and ASC Topic 842, Leases (“ASC 842”). ASC 842 requires a lessee to record a right-of-use asset and a corresponding lease liability for most lease arrangements on the Company's balance sheet. Under the standard, disclosure of key information about leasing arrangements to assist users of the financial statements with assessing the amount, timing and uncertainty of cash flows arising from leases is required. Leases are classified as either finance leases or operating leases. A lease is classified as a finance lease if any one of the following criteria are met: the lease transfers ownership of the asset by the end of the lease term, the lease contains an option to purchase the asset that is reasonably certain to be exercised, the lease term is for a major part of the remaining useful life of the asset or the present value of the lease payments equals or exceeds substantially all of the fair value of the asset. A lease is classified as an operating lease if it does not meet any of these criteria. For all leases at the lease commencement date, a right-of-use asset and a lease liability are recognized. The right-of-use asset represents the right to use the leased asset for the lease term. The lease liability represents the present value of the lease payments under the lease. The right-of-use asset is initially measured at cost, which primarily comprises the initial amount of the lease liability, plus any initial direct costs incurred if any, less any lease incentives received. All right-of-use assets are reviewed for impairment. The lease liability is initially measured at the present value of the lease payments, discounted using the interest rate implicit in the lease or, if that rate cannot be readily determined, the secured incremental borrowing rate for the same term as the underlying lease. Lease payments included in the measurement of the lease liability comprise the following: the fixed noncancelable lease payments, payments for optional renewal periods where it is reasonably certain the renewal period will be exercised, and payments for early termination options unless it is reasonably certain the lease will not be terminated early. Lease cost for operating leases consists of the lease payments plus any initial direct costs, primarily brokerage commissions, and is recognized on a straight-line basis over the lease term. Included in lease cost are any variable lease payments incurred in the period that are not included in the initial lease liability and lease payments incurred in the period for any leases with an initial term of 12 months or less. Lease cost for finance leases consists of the amortization of the right-of-use asset on a straight-line basis over the lease term and interest expense determined on an amortized cost basis. The lease payments are allocated between a reduction of the lease liability and interest expense. The Company has made an accounting policy election to not recognize leases with an initial term of 12 months or less within our condensed consolidated balance sheets and to recognize those lease payments on a straight-line basis in our condensed consolidated statements of operations and comprehensive loss over the lease term. Equipment and Improvements Equipment and improvements are stated at cost, less accumulated depreciation. For financial reporting purposes, depreciation is recognized using the straight-line method, allocating the cost of the assets over their estimated usefulness from three to five years for network equipment, office equipment, and furniture classified as fixed assets.
|
|
|
|
|
Estimated Useful Economic Life |
Leasehold property improvements, right-of-use assets |
|
Lesser of lease term or useful life |
Furniture and office equipment |
|
3-5 years |
Lab equipment |
|
3 years |
IT equipment |
|
3 years |
Fair Value Measurement The Company has certain financial assets and liabilities recorded at fair value which have been classified as Level 1, 2 or 3 within the fair value hierarchy as described in the accounting standards for fair value measurements. · Level 1 — Fair values are determined utilizing quoted prices (unadjusted) in active markets for identical assets or liabilities that the Company has the ability to access; · Level 2 — Fair values are determined by utilizing quoted prices for identical or similar assets and liabilities in active markets or other market observable inputs such as interest rates, yield curves and foreign currency spot rates; and · Level 3 — Inputs are unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s financial assets, which include cash equivalents and marketable securities, have been initially valued at the transaction price, and subsequently revalued at the end of each reporting period, utilizing third-party pricing services. The pricing services utilize industry standard valuation models, including both income and market based approaches, to determine value and improvements are stated at cost, less accumulated depreciation. Marketable Securities The Company's marketable securities consist of U.S. Treasury securities with maturities of less than one year which are classified as available-for-sale and included in current assets on the condensed consolidated balance sheets. Available-for-sale debt securities are carried at fair value with unrealized gains and losses reported as a component of stockholders’ equity in accumulated other comprehensive income (loss). Realized gains and losses, if any, are included in other income, net in the condensed consolidated statements of operations and comprehensive loss. Available-for-sale securities are reviewed for possible impairment at least quarterly, or more frequently if circumstances arise that may indicate impairment. When the fair value of the securities declines below the amortized cost basis, impairment is indicated and it must be determined whether it is other than temporary. Impairment is considered to be other than temporary if the Company: (i) intends to sell the security, (ii) will more likely than not be forced to sell the security before recovering its cost, or (iii) does not expect to recover the security’s amortized cost basis. If the decline in fair value is considered other than temporary, the cost basis of the security is adjusted to its fair market value and the realized loss is reported.
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v3.24.2.u1
Fair Value of Financial Instruments
|
6 Months Ended |
Jun. 30, 2024 |
Fair Value Disclosures [Abstract] |
|
Fair Value of Financial Instruments |
4.Fair Value of Financial Instruments The following table summarizes cash equivalents and marketable securities measured at their fair value on a recurring basis as of June 30, 2024:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of June 30, 2024 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
Total |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
Total |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of December 31, 2023 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
Total |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
|
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- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.24.2.u1
Marketable Securities
|
6 Months Ended |
Jun. 30, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Marketable Securities |
Marketable securities consisted of the following as of:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
Total |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2023 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
As of June 30, 2024, the Company held 18 U.S. Treasury debt securities that were in an unrealized loss position totaling $1,024. As of December 31, 2023, the Company held three U.S. Treasury debt securities that were in an unrealized gain position totaling $877. All U.S. Treasury obligations were due to mature in less than one year for the period and year ended June 30, 2024 and December 31, 2023, respectively. The Company received proceeds of $8.4 million from maturities of marketable securities for the six months ended June 30, 2024. The Company received proceeds of $41.1 million from maturities of marketable securities for the year ended December 31, 2023. The Company did not realize any gains or losses from maturities of marketable securities for the period ended June 30, 2024 or the year ended December 31, 2023.
|
X |
- DefinitionThe entire disclosure of cash, cash equivalents, and debt and equity securities, including any unrealized or realized gain (loss).
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v3.24.2.u1
Equipment and Improvements
|
6 Months Ended |
Jun. 30, 2024 |
Property, Plant and Equipment [Abstract] |
|
Equipment and Improvements |
6.Equipment and Improvements
|
|
|
|
|
|
|
|
|
Equipment and Improvements, net |
|
|
|
June 30, |
|
|
December 31, |
|
|
|
2024 |
|
|
2023 |
|
Furniture and office equipment |
|
$ |
86,930 |
|
|
$ |
86,930 |
|
IT equipment |
|
|
16,895 |
|
|
|
16,895 |
|
|
|
|
103,825 |
|
|
|
103,825 |
|
Less: Accumulated depreciation |
|
|
43,590 |
|
|
|
30,453 |
|
Total |
|
$ |
60,235 |
|
|
$ |
73,372 |
|
Depreciation expense for the three and six months ended June 30, 2024 was $6,569 and $13,137, respectively. Depreciation expense for the three and six months ended June 30, 2023 was $159,204 and $164,247, respectively.
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- DefinitionThe entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections.
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v3.24.2.u1
Supplemental Balance Sheet Information
|
6 Months Ended |
Jun. 30, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Supplemental Balance Sheet Information |
7.Supplemental Balance Sheet Information Accrued expenses and other current liabilities consist of the following:
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued consulting |
|
$ |
54,298 |
|
|
$ |
49,395 |
|
Accrued compensation |
|
|
486,956 |
|
|
|
635,451 |
|
Accrued research and development |
|
|
1,482,340 |
|
|
|
1,472,292 |
|
Accrued other |
|
|
10,931 |
|
|
|
102,817 |
|
Total accrued expenses and other current liabilities |
|
$ |
2,034,525 |
|
|
$ |
2,259,955 |
|
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- DefinitionThe entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity.
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v3.24.2.u1
Stockholders' Equity
|
6 Months Ended |
Jun. 30, 2024 |
Stockholders' Equity Note [Abstract] |
|
Stockholders' Equity |
Each share of common stock is entitled to one vote. The holders of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the board of directors, subject to the prior rights of holders of all classes of stock outstanding. As of June 30, 2024, a total of 3,589,232 shares of common stock were reserved for issuance upon the exercise of outstanding stock options and warrants under the 2020 Equity Incentive Plan (the "2020 Plan") and the 2011 Equity Incentive Plan. Share Issuances On February 1, 2024, the Company entered into an At The Market Offering (the “ATM”) with H.C. Wainwright & Co., LLC as sales agent (the “Agent”), pursuant to which the Company may, from time to time, issue and sell shares of its common stock, at an aggregate offering price of up to approximately $5.7 million (the “Shares”) through the Agent. Under the terms of the Agreement, the Agent may sell the Shares at market prices by any method that is deemed to be an “ATM” as defined in Rule 415 under the Securities Act, as amended. On May 20, 2024, the Company reduced the aggregate offering price to $50,000, not including the shares of common stock previously sold. Subject to the terms and conditions of the Agreement, the Agent will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company’s instructions. The Company has no obligation to sell any of the Shares, and may at any time suspend sales under the Agreement or terminate the Agreement in accordance with its terms. The Company has provided the Agent with customary indemnification rights, and the Agent will be entitled to a fixed commission of 3.0% of the aggregate gross proceeds from the Shares sold. The Agreement contains customary representations and warranties, and the Company is required to deliver customary closing documents and certificates in connection with sales of the Shares. As of June 30, 2024, 315,338 ATM Shares have been sold under the Agreement with net proceeds of $820,509 to the Company. On May 20, 2024, the Company entered into a securities purchase agreement with a single institutional investor in connection with a registered direct offering and concurrent private placement with the same institutional investor (collectively the "May 2024 Offering"). The May 2024 Offering consisted of (i) 714,527 shares of the Company's common stock sold at $1.68 per share, (ii) Pre-Funded Common Warrants to purchase up to 957,925 shares of common stock with an exercise price of $0.0001 which are immediately exercisable after the issuance until exercised in full, (iii) Series A Common Warrants to purchase 1,672,452 shares of common stock with an exercise price of $1.68 per share which expire on the one-year anniversary from the date of stockholder approval, and (iv) Series B Common Warrants to purchase 1,672,452 shares of common stock with an exercise price of $1.68 per share which expire on the five-year anniversary from the date of stockholder approval. All of the warrants in the May 2024 Offering were issued to a single investor. As of the date of issuance, the investor exercised 247,925 Pre-Funded Common Warrants. The Company received net proceeds from the May 2024 Offering of approximately $2.2 million. On May 20, 2024, the Company also entered into a warrant inducement agreement with the same investor to exercise certain outstanding warrants that the Company issued in January 2023 ("January 2023 Existing Warrants"). Pursuant to the warrant inducement agreement, the investor agreed to exercise outstanding warrants to purchase an aggregate of 708,500 shares of the Company's common stock at an amended exercise price of $1.68 per share. These shares are held in abeyance and not considered outstanding. The shares held in abeyance will be held in abeyance until notice from the investor that the balance, or portion thereof, may be issued in compliance with a beneficial ownership limitation provision in the warrants. The Company also agreed to reduce the exercise price of the remaining unexercised portion of such warrants to purchase 1,229,484 shares of common stock to $1.68 per share and to issue the investor Series C Common Warrants to purchase 708,500 shares of the Company's common stock and Series D Common Warrants to purchase 708,500 shares of the Company's common stock ("January 2023 New Warrants"). Each will have an exercise price of $1.68 per share and will be exercisable beginning on the effective date of stockholder approval. The Series C Common Warrants will expire on the one-year anniversary from the date of stockholder approval and the Series D Common Warrants will expire on the five-year anniversary from the date of stockholder approval. The repricing of the January 2023 Existing Warrants and issuance of the Series C Common Warrants and the Series D Common Warrants is considered a modification of the January 2023 Existing Warrants under the guidance of ASU 2021-04. The modification is consistent with the "Equity Issuance" classification under that guidance as the reason for the modification was to induce the holder to cash exercise their warrants, resulting in the imminent exercise of the January 2023 Existing Warrants, which raised equity capital and generated net proceeds for the Company of approximately $1.0 million. The total fair value of the consideration of the modification includes the incremental fair value of the January 2023 Existing Warrants (determined by comparing the fair values immediately prior to and immediately after the modification) and the initial fair value of the January 2023 New Warrants. The fair values were calculated using the Black-Scholes model and the Company determined that the total fair value of the consideration related to the modification of the January 2023 Existing Warrants, including the initial fair value of the January 2023 New Warrants was $1.8 million
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- DefinitionThe entire disclosure for equity.
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v3.24.2.u1
Stock-Based Compensation
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Stock-Based Compensation |
9.Stock-Based Compensation 2020 Equity Incentive Plan The Company’s 2020 Plan was established for granting stock incentive awards to directors, officers, employees and consultants to the Company. Stock Options During the six months ended June 30, 2024, the Company granted 188,039 options with a weighted average strike price of $2.12 to purchase common stock to certain employees that either (i) vest annually in three equal parts over three years or (ii) vest on the first anniversary of the grant of such option in the mount of one-third of such grant, and the remaining portion will vest in 24 equal monthly installments thereafter. The Company granted 45,000 performance-based options with a weighted average strike price of $2.16 to purchase common stock to certain employees. These options are subject to performance vesting and will vest and become exercisable once the performance conditions are probable of being met. There is no assurance that the performance conditions will be met and therefore some or all of these options may never vest or become exercisable. The total aggregate grant date fair value of all options granted was $359,032. During the three months ended June 30, 2024, certain performance conditions were met. During the six months ended June 30, 2023, the Company granted 86,669 options with a weighted average strike price of $2.81 to purchase common stock to certain employees that will either (i) vest annually in three equal parts over three years or (ii) vest on the first anniversary of the grant of such option in the amount of one-third of such grant, and the remaining portion will vest in 24 equal monthly installments thereafter. The Company granted 25,000 performance-based options with a weighted average strike price of $1.33 to purchase common stock to certain employees. These options are subject to performance vesting and will vest and become exercisable once the performance conditions have been met. There is no assurance that the performance conditions will be met and therefore some or all of these options may never vest or become exercisable. The total aggregate grant date fair value of all options granted was $338,738. During the six months ended June 30, 2023, no performance conditions were met. For awards with performance conditions in which the award does not vest unless the performance condition is met, we recognize expense if, and to the extent that, we estimate that achievement of the performance condition is probable. If we conclude that vesting is probable, we recognize expense from the date we reach this conclusion through the estimated vesting date. Stock-Based Compensation Expense The following table summarizes the stock-based compensation expense for stock options granted to employees and non-employees:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Research and development |
|
$ |
(7,706 |
) |
|
$ |
40,259 |
|
|
$ |
10,224 |
|
|
$ |
78,876 |
|
Selling, general and administrative |
|
|
38,403 |
|
|
|
84,586 |
|
|
|
73,907 |
|
|
|
169,242 |
|
Total stock-based compensation expense |
|
$ |
30,697 |
|
|
$ |
124,845 |
|
|
$ |
84,131 |
|
|
$ |
248,118 |
|
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.24.2.u1
ATM Program
|
6 Months Ended |
Jun. 30, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
ATM Program |
On February 1, 2024, the Company entered into an At The Market Offering (the “ATM”) with H.C. Wainwright & Co., LLC as sales agent (the “Agent”), pursuant to which the Company may, from time to time, issue and sell shares of its common stock, at an aggregate offering price of up to approximately $5.7 million (the “Shares”) through the Agent. Under the terms of the Agreement, the Agent may sell the Shares at market prices by any method that is deemed to be an “ATM” as defined in Rule 415 under the Securities Act, as amended. On May 20, 2024, the Company reduced the aggregate offering price to $50,000, not including the shares of common stock previously sold. Subject to the terms and conditions of the Agreement, the Agent will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company’s instructions. The Company has no obligation to sell any of the Shares, and may at any time suspend sales under the Agreement or terminate the Agreement in accordance with its terms. The Company has provided the Agent with customary indemnification rights, and the Agent will be entitled to a fixed commission of 3.0% of the aggregate gross proceeds from the Shares sold. The Agreement contains customary representations and warranties, and the Company is required to deliver customary closing documents and certificates in connection with sales of the Shares. As of June 30, 2024, 315,338 ATM Shares have been sold under the Agreement with net proceeds of $820,509 to the Company.
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v3.24.2.u1
Net Loss Per Share
|
6 Months Ended |
Jun. 30, 2024 |
Earnings Per Share [Abstract] |
|
Net Loss Per Share |
The following table presents the calculation of basic and diluted net loss per share applicable to common stockholders. Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted-average number of shares outstanding during the period which includes pre-funded warrants and shares held in abeyance from date of issuance.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(4,959,608 |
) |
|
$ |
(5,777,966 |
) |
|
$ |
(9,609,243 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
7,535,667 |
|
|
|
6,162,280 |
|
|
|
6,939,779 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.66 |
) |
|
$ |
(0.94 |
) |
|
$ |
(1.38 |
) |
|
$ |
(1.74 |
) |
The following shares were excluded from the calculation of diluted net loss per share applicable to common stockholders, prior to the application of the treasury stock method, because their effect would have been anti-dilutive for the periods presented:
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Options to purchase shares of stock |
|
|
1,020,280 |
|
|
|
835,913 |
|
Warrants to purchase shares of stock |
|
|
7,985,965 |
|
|
|
3,137,590 |
|
Total |
|
|
9,006,245 |
|
|
|
3,973,503 |
|
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v3.24.2.u1
Income Taxes
|
6 Months Ended |
Jun. 30, 2024 |
Income Tax Disclosure [Abstract] |
|
Income Taxes |
During the three and six months ended June 30, 2024 and 2023, there was no provision for income taxes as the Company incurred losses during those periods. Deferred tax assets and liabilities reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. The Company recorded a full valuation allowance against its deferred tax assets as the Company believes it is more likely than not the deferred tax assets will not be realized.
|
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v3.24.2.u1
Commitments and Contingencies
|
6 Months Ended |
Jun. 30, 2024 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
13.Commitments and Contingencies Litigation On April 26, 2024, the Company received a notice of a demand for arbitration with the American Arbitration Association from Pivot Holding LLC (“Pivot”), that alleges to be a successor in interest to Sphaera Pharma Pte. Ltd. (“Sphaera”), in connection with the Collaborative Research and Development Agreement dated February 29, 2012, as amended, between the Company and Sphaera (the "Agreement"). Pivot alleges breach of contract by the Company for failure to pay milestone payments and seeks damages of $1.625 million in milestone payments plus interest. The Company believes that Pivot’s claims are without merit and that the Company hasn’t owed and doesn’t owe any milestone payments to Pivot. The Company intends to vigorously dispute Pivot’s claims. The parties have agreed to mediate before arbitrating and a mediation is scheduled for September 6, 2024. On June 17, 2024, the Company filed an answering statement and counterclaim, in which Inhibikase disputed Pivot’s claims and counterclaimed that Sphaera had breached the Agreement by failing to complete properly the drug development work required by the Agreement, causing the Company over $900,000 in damages. Lease On April 18, 2022, the Company entered into an operating lease agreement for office space at its new location in Lexington, Massachusetts (the "Office Lease"). On August 8, 2022, the Company commenced occupancy of the leased space. The lease runs through September 30, 2025. We have an option to extend the lease term for an additional three (3) years thereafter. The Company accounts for the Office Lease under the provisions of ASC 842. We recorded a right-of-use asset and a corresponding operating lease liability on the Company's condensed consolidated balance sheets upon the accounting commencement date in August 2022. The lease liability was measured at the accounting commencement date utilizing a 12% discount rate. The right-of-use asset had a balance of $163,762 at June 30, 2024. The operating lease obligations totaled $177,830 at June 30, 2024, of which $152,224 is included under current liabilities and $25,606 is included under non-current liabilities. The Company recorded lease expense of $32,296 and $70,591 and other short-term payments of $5,653 and $11,306 for the three and six months ended June 30, 2024, respectively in selling, general and administrative expenses and lease expense relating to the Office Lease of $35,296 and $70,591 and other short-term payments of $5,788 and $11,576 for the three and six months ended June 30, 2023, respectively in selling, general and administrative expenses. The Office Lease contains escalating payments during the lease period. Upon execution of the Office Lease, the Company prepaid one month of rent and a security deposit, one of which will be held in escrow and credited at the termination of the lease and the other of which will be applied to the first month’s rent. As of June 30, 2024, a security deposit of approximately $25,000 was included in prepaid expenses and other current assets on the Company’s condensed consolidated balance sheet related to the Office Lease. Future minimum lease payments under this lease at June 30, 2024, are presented by calendar year as follows:
|
|
|
|
|
Year |
|
|
|
2024 |
|
$ |
75,580 |
|
2025 |
|
|
114,966 |
|
Total lease payments |
|
|
190,546 |
|
Less: imputed interest |
|
|
(12,716 |
) |
Present value of operating lease liabilities |
|
$ |
177,830 |
|
|
X |
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v3.24.2.u1
Correction of Prior Period Immaterial Error
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Changes and Error Corrections [Abstract] |
|
Correction of Prior Period Immaterial Error: |
14. Correction of Prior Period Immaterial Error: The Company has identified an immaterial error in the Company's previously issued consolidated financial statements related to net loss per share and weighted-average number of common shares outstanding. The error pertains to the exclusion of pre-funded warrants from the January 2023 transaction in the weighted-average number of common shares used in the calculation of net loss per share, the effect of which improves net loss per share. In evaluating whether the previously issued Consolidated Financial Statements were materially misstated for the interim or annual periods prior to December 31, 2023, the Company applied the guidance of ASC 250, Accounting Changes and Error Corrections, SEC Staff Accounting Bulletin (“SAB”) Topic 1.M, Assessing Materiality and SAB Topic 1.N, Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements and concluded that the effect of the errors on prior period annual financial statements was immaterial. The guidance states that prior-year misstatements which, if corrected in the current year would materially misstate the current year’s financial statements, must be corrected by adjusting prior year financial statements, even though such correction previously was and continues to be immaterial to the prior-year financial statements. This is because if left uncorrected over time the difference to weighted-average shares outstanding could have grown to be material. Correcting prior-year financial statements for such immaterial misstatements does not require previously filed reports to be amended. The adjustment required to correct the misstatement in the financial statements for the three and six months ended June 30, 2023 is reflected in these consolidated statements of operations which are presented on a comparative basis with those for the three and six months ended June 30, 2024. In accordance with ASC 250, Accounting Changes and Error Correction, the Company is hereby reporting the correction of the weighted-average common shares outstanding and net loss per share line items of its consolidated interim statements of operations for 2023 and its consolidated 2023 statement of operations. The Company's consolidated statements of operations have been revised from the amounts previously reported to correct the error as shown in the tables below.
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended March 31, |
|
|
Three Months Ended March 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,477,778 |
) |
|
$ |
(4,477,778 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,585,013 |
|
|
|
5,582,631 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.98 |
) |
|
$ |
(0.80 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended June 30, |
|
|
Three Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(5,777,966 |
) |
|
$ |
(5,777,966 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,226,101 |
|
|
|
6,162,280 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(1.11 |
) |
|
$ |
(0.94 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Six Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(10,255,744 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,918,206 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.09 |
) |
|
$ |
(1.74 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended September 30, |
|
|
Three Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,595,199 |
) |
|
$ |
(4,595,199 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,342,337 |
|
|
|
6,162,671 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.86 |
) |
|
$ |
(0.75 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Nine Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(14,850,943 |
) |
|
$ |
(14,850,943 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,060,447 |
|
|
|
5,977,841 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.93 |
) |
|
$ |
(2.48 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Year ended December 31, |
|
|
Year ended December 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(19,028,883 |
) |
|
$ |
(19,028,883 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted (restated) |
|
|
5,333,096 |
|
|
|
6,028,210 |
|
Net loss per share applicable to common stockholders – basic and diluted (restated) |
|
$ |
(3.57 |
) |
|
$ |
(3.16 |
) |
|
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- DefinitionThe entire disclosure for reporting error correction.
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v3.24.2.u1
Basis of Presentation and Significant Accounting Policies (Policies)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Basis of Presentation of Interim Financial Statements |
Basis of Presentation of Interim Financial Statements The accompanying unaudited condensed consolidated financial statements were prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim financial statements and, in the opinion of management, include all normal and recurring adjustments necessary to present fairly the results of the interim periods shown. The December 31, 2023 balance sheet was derived from December 31, 2023 audited financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles (“US GAAP”) have been condensed or omitted pursuant to such SEC rules and regulations. Management believes that the disclosures made are adequate to make the information presented not misleading. The results for the interim periods are not necessarily indicative of results to be expected for the fiscal year ending December 31, 2024. The unaudited condensed consolidated financial statements contained herein should be read in conjunction with the Company’s annual audited financial statements and notes thereto for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC. The unaudited condensed consolidated financial statements have been prepared in conformity with US GAAP, which prescribes elimination of all significant intercompany accounts and transactions in the accounts of the Company and its wholly-owned subsidiary, IKT Securities Corporation, Inc., which was incorporated in the Commonwealth of Massachusetts in December 2021. Any reference in these notes to applicable guidance is meant to refer to the authoritative US GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Update (“ASU”) of the Financial Accounting Standards Board (“FASB”). From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies and are generally adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its financial position or results of operations upon adoption. The Company qualifies as an “emerging growth company” as defined in the Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act. The JOBS Act permits an emerging growth company such as the Company to take advantage of an extended transition period to comply with new or revised accounting standards applicable to public companies until those standards would otherwise apply to private companies. The Company has elected not to “opt out” of such extended transition period, which means that when a standard is issued or revised and it has different application dates for public or private companies, the Company will adopt the new or revised standard at the time private companies adopt the new or revised standard and will do so until such time that it either (i) irrevocably elects to “opt out” of such extended transition period or (ii) no longer qualifies as an emerging growth company. On June 30, 2023, we effected a reverse stock split at the ratio of 1 post-split share for every 6 pre-split shares. All common stock, options, warrant amounts, per share information and references have been retroactively adjusted for all figures presented to reflect this split unless specifically stated otherwise.
|
Use of Estimates |
Use of Estimates The preparation of the Company’s financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The Company utilizes certain estimates in the determination of our liquidity and working capital adequacy, the fair value of its stock options and warrants, deferred tax valuation allowances and revenue recognition, to record expenses relating to research and development contracts and accrued expenses. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from such estimates.
|
New Accounting Pronouncements |
New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies that the Company adopts as of the specified effective date. Unless otherwise discussed below, the Company does not believe that the adoption of recently issued standards have or may have a material impact on its condensed consolidated financial statements and disclosures.
|
Concentrations of Credit Risk |
Concentrations of Credit Risk For the three and six months ended June 30, 2024, the Company did not report any revenues. For the three and six months ended June 30, 2023, the Company derived 100% of its total revenue from a single source, the United States Government, in the form of federal research grants.
|
Revenue Recognition |
Revenue Recognition The Company generates revenue from research and development grants under contracts with third parties that do not create customer-vendor relationships. The Company’s research and development grants are non-exchange transactions and are not within the scope of ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”). Contribution revenue earned from activities performed pursuant to research and development grants is reported as grant revenue in the Company’s unaudited condensed consolidated statements of operations and comprehensive loss. Revenue from these grants is recognized as the Company incurs qualifying expenses as stipulated by the terms of the respective grant. Cash received from grants in advance of incurring qualifying expenses is recorded as deferred revenue. The Company records revenue and a corresponding receivable when qualifying costs are incurred before the grants are received.
|
Research and Development Costs |
Research and Development Costs Costs incurred in the research and development of the Company’s product candidates are expensed as incurred. Research and development expenses consist of costs incurred in performing research and development activities, including activities associated with performing services under grant revenue contracts and include salaries and benefits, stock compensation, research-related subcontractors and consultants, supplies and overhead costs. Advance payments made to suppliers and contract research organizations are classified as prepaid research and development and are expensed as research and development as the supplies are consumed and the contract services are provided. During the three and six months ended June 30, 2024, the Company incurred expenses of approximately $175 thousand and $297 thousand, respectively, with a related party vendor included in research and development expenses. During the three and six months ended June 30, 2023, the Company did not incur any expenses with a related party vendor that were included in research and development expenses. As at the period ended June 30, 2024 and December 31, 2023, the Company had a payable or accrued expense balance with a related party vendor of approximately $125 thousand and $57 thousand, respectively, included in accounts payable and accrued expenses.
|
Leases |
Leases The Company accounts for its leases under ASU 2021-09, ASU 2018-10, and ASC Topic 842, Leases (“ASC 842”). ASC 842 requires a lessee to record a right-of-use asset and a corresponding lease liability for most lease arrangements on the Company's balance sheet. Under the standard, disclosure of key information about leasing arrangements to assist users of the financial statements with assessing the amount, timing and uncertainty of cash flows arising from leases is required. Leases are classified as either finance leases or operating leases. A lease is classified as a finance lease if any one of the following criteria are met: the lease transfers ownership of the asset by the end of the lease term, the lease contains an option to purchase the asset that is reasonably certain to be exercised, the lease term is for a major part of the remaining useful life of the asset or the present value of the lease payments equals or exceeds substantially all of the fair value of the asset. A lease is classified as an operating lease if it does not meet any of these criteria. For all leases at the lease commencement date, a right-of-use asset and a lease liability are recognized. The right-of-use asset represents the right to use the leased asset for the lease term. The lease liability represents the present value of the lease payments under the lease. The right-of-use asset is initially measured at cost, which primarily comprises the initial amount of the lease liability, plus any initial direct costs incurred if any, less any lease incentives received. All right-of-use assets are reviewed for impairment. The lease liability is initially measured at the present value of the lease payments, discounted using the interest rate implicit in the lease or, if that rate cannot be readily determined, the secured incremental borrowing rate for the same term as the underlying lease. Lease payments included in the measurement of the lease liability comprise the following: the fixed noncancelable lease payments, payments for optional renewal periods where it is reasonably certain the renewal period will be exercised, and payments for early termination options unless it is reasonably certain the lease will not be terminated early. Lease cost for operating leases consists of the lease payments plus any initial direct costs, primarily brokerage commissions, and is recognized on a straight-line basis over the lease term. Included in lease cost are any variable lease payments incurred in the period that are not included in the initial lease liability and lease payments incurred in the period for any leases with an initial term of 12 months or less. Lease cost for finance leases consists of the amortization of the right-of-use asset on a straight-line basis over the lease term and interest expense determined on an amortized cost basis. The lease payments are allocated between a reduction of the lease liability and interest expense. The Company has made an accounting policy election to not recognize leases with an initial term of 12 months or less within our condensed consolidated balance sheets and to recognize those lease payments on a straight-line basis in our condensed consolidated statements of operations and comprehensive loss over the lease term.
|
Equipment and Improvements |
Equipment and Improvements Equipment and improvements are stated at cost, less accumulated depreciation. For financial reporting purposes, depreciation is recognized using the straight-line method, allocating the cost of the assets over their estimated usefulness from three to five years for network equipment, office equipment, and furniture classified as fixed assets.
|
|
|
|
|
Estimated Useful Economic Life |
Leasehold property improvements, right-of-use assets |
|
Lesser of lease term or useful life |
Furniture and office equipment |
|
3-5 years |
Lab equipment |
|
3 years |
IT equipment |
|
3 years |
Fair Value Measurement The Company has certain financial assets and liabilities recorded at fair value which have been classified as Level 1, 2 or 3 within the fair value hierarchy as described in the accounting standards for fair value measurements. · Level 1 — Fair values are determined utilizing quoted prices (unadjusted) in active markets for identical assets or liabilities that the Company has the ability to access; · Level 2 — Fair values are determined by utilizing quoted prices for identical or similar assets and liabilities in active markets or other market observable inputs such as interest rates, yield curves and foreign currency spot rates; and · Level 3 — Inputs are unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s financial assets, which include cash equivalents and marketable securities, have been initially valued at the transaction price, and subsequently revalued at the end of each reporting period, utilizing third-party pricing services. The pricing services utilize industry standard valuation models, including both income and market based approaches, to determine value and improvements are stated at cost, less accumulated depreciation.
|
Marketable Securities |
Marketable Securities The Company's marketable securities consist of U.S. Treasury securities with maturities of less than one year which are classified as available-for-sale and included in current assets on the condensed consolidated balance sheets. Available-for-sale debt securities are carried at fair value with unrealized gains and losses reported as a component of stockholders’ equity in accumulated other comprehensive income (loss). Realized gains and losses, if any, are included in other income, net in the condensed consolidated statements of operations and comprehensive loss. Available-for-sale securities are reviewed for possible impairment at least quarterly, or more frequently if circumstances arise that may indicate impairment. When the fair value of the securities declines below the amortized cost basis, impairment is indicated and it must be determined whether it is other than temporary. Impairment is considered to be other than temporary if the Company: (i) intends to sell the security, (ii) will more likely than not be forced to sell the security before recovering its cost, or (iii) does not expect to recover the security’s amortized cost basis. If the decline in fair value is considered other than temporary, the cost basis of the security is adjusted to its fair market value and the realized loss is reported.
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- DefinitionDisclosure of accounting policy for revenue from contract with customer.
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v3.24.2.u1
Basis of Presentation and Significant Accounting Policies (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Property plant estimated useful life |
For financial reporting purposes, depreciation is recognized using the straight-line method, allocating the cost of the assets over their estimated usefulness from three to five years for network equipment, office equipment, and furniture classified as fixed assets.
|
|
|
|
|
Estimated Useful Economic Life |
Leasehold property improvements, right-of-use assets |
|
Lesser of lease term or useful life |
Furniture and office equipment |
|
3-5 years |
Lab equipment |
|
3 years |
IT equipment |
|
3 years |
|
X |
- References
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- DefinitionTabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation.
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v3.24.2.u1
Fair Value of Financial Instruments (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Fair Value Disclosures [Abstract] |
|
Summery of Fair Value Assets Measured On Recurring Basis |
The following table summarizes cash equivalents and marketable securities measured at their fair value on a recurring basis as of June 30, 2024:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of June 30, 2024 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
Total |
|
$ |
1,012,040 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
1,012,040 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
Total |
|
$ |
4,853,559 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurements as of December 31, 2023 Using: |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market funds |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
Total |
|
$ |
8,039,024 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
8,039,024 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,086,873 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
|
X |
- DefinitionTabular disclosure of assets, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, by class that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3).
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v3.24.2.u1
Marketable Securities (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Investments, Debt and Equity Securities [Abstract] |
|
Marketable Securities [Table Text Block] |
Marketable securities consisted of the following as of:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
Total |
|
$ |
4,854,583 |
|
|
$ |
— |
|
|
$ |
(1,024 |
) |
|
$ |
4,853,559 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2023 |
|
Amortized Cost |
|
|
Unrealized Gain |
|
|
Unrealized Loss |
|
|
Fair Value |
|
Marketable securities, available-for-sale: |
|
|
|
|
|
|
|
|
|
|
|
|
U.S. Treasury obligations |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
Total |
|
$ |
4,085,996 |
|
|
$ |
877 |
|
|
$ |
— |
|
|
$ |
4,086,873 |
|
|
X |
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v3.24.2.u1
Equipment and Improvements (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Property, Plant and Equipment [Abstract] |
|
Schedule Of Equipment and Improvements |
|
|
|
|
|
|
|
|
|
Equipment and Improvements, net |
|
|
|
June 30, |
|
|
December 31, |
|
|
|
2024 |
|
|
2023 |
|
Furniture and office equipment |
|
$ |
86,930 |
|
|
$ |
86,930 |
|
IT equipment |
|
|
16,895 |
|
|
|
16,895 |
|
|
|
|
103,825 |
|
|
|
103,825 |
|
Less: Accumulated depreciation |
|
|
43,590 |
|
|
|
30,453 |
|
Total |
|
$ |
60,235 |
|
|
$ |
73,372 |
|
|
X |
- DefinitionSchedule Of Equipment and Improvements Table [Text Block]
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v3.24.2.u1
Supplemental Balance Sheet Information (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Schedule of Accrued Expenses and Other Current Liabilities |
Accrued expenses and other current liabilities consist of the following:
|
|
|
|
|
|
|
|
|
|
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued consulting |
|
$ |
54,298 |
|
|
$ |
49,395 |
|
Accrued compensation |
|
|
486,956 |
|
|
|
635,451 |
|
Accrued research and development |
|
|
1,482,340 |
|
|
|
1,472,292 |
|
Accrued other |
|
|
10,931 |
|
|
|
102,817 |
|
Total accrued expenses and other current liabilities |
|
$ |
2,034,525 |
|
|
$ |
2,259,955 |
|
|
X |
- DefinitionSchedule of accrued expenses and other current liabilities.
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v3.24.2.u1
Stock-Based Compensation (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Summary of Stock-Based Compensation Expense for Stock Options Granted to Employees and Non-Employees |
The following table summarizes the stock-based compensation expense for stock options granted to employees and non-employees:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Research and development |
|
$ |
(7,706 |
) |
|
$ |
40,259 |
|
|
$ |
10,224 |
|
|
$ |
78,876 |
|
Selling, general and administrative |
|
|
38,403 |
|
|
|
84,586 |
|
|
|
73,907 |
|
|
|
169,242 |
|
Total stock-based compensation expense |
|
$ |
30,697 |
|
|
$ |
124,845 |
|
|
$ |
84,131 |
|
|
$ |
248,118 |
|
|
X |
- DefinitionTabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.
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v3.24.2.u1
Net Loss Per Share (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Earnings Per Share [Abstract] |
|
Summary of Calculation of Basic and Diluted Net Loss Per Share applicable to Common Stockholders |
The following table presents the calculation of basic and diluted net loss per share applicable to common stockholders. Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted-average number of shares outstanding during the period which includes pre-funded warrants and shares held in abeyance from date of issuance.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(4,959,608 |
) |
|
$ |
(5,777,966 |
) |
|
$ |
(9,609,243 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
7,535,667 |
|
|
|
6,162,280 |
|
|
|
6,939,779 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.66 |
) |
|
$ |
(0.94 |
) |
|
$ |
(1.38 |
) |
|
$ |
(1.74 |
) |
|
Summary of Shares Excluded from Calculation of Diluted Net Loss per Share Applicable to Common Stockholders |
The following shares were excluded from the calculation of diluted net loss per share applicable to common stockholders, prior to the application of the treasury stock method, because their effect would have been anti-dilutive for the periods presented:
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Options to purchase shares of stock |
|
|
1,020,280 |
|
|
|
835,913 |
|
Warrants to purchase shares of stock |
|
|
7,985,965 |
|
|
|
3,137,590 |
|
Total |
|
|
9,006,245 |
|
|
|
3,973,503 |
|
|
X |
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- DefinitionTabular disclosure of undiscounted cash flows of lessee's operating lease liability. Includes, but is not limited to, reconciliation of undiscounted cash flows to operating lease liability recognized in statement of financial position.
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v3.24.2.u1
Correction of Prior Period Immaterial Error (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Changes and Error Corrections [Abstract] |
|
Schedule of Error Corrections and Prior Period Adjustments |
The Company's consolidated statements of operations have been revised from the amounts previously reported to correct the error as shown in the tables below.
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended March 31, |
|
|
Three Months Ended March 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,477,778 |
) |
|
$ |
(4,477,778 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,585,013 |
|
|
|
5,582,631 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.98 |
) |
|
$ |
(0.80 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended June 30, |
|
|
Three Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(5,777,966 |
) |
|
$ |
(5,777,966 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,226,101 |
|
|
|
6,162,280 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(1.11 |
) |
|
$ |
(0.94 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Six Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(10,255,744 |
) |
|
$ |
(10,255,744 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
4,918,206 |
|
|
|
5,883,895 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.09 |
) |
|
$ |
(1.74 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Three Months Ended September 30, |
|
|
Three Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(4,595,199 |
) |
|
$ |
(4,595,199 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,342,337 |
|
|
|
6,162,671 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(0.86 |
) |
|
$ |
(0.75 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Nine Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(14,850,943 |
) |
|
$ |
(14,850,943 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted |
|
|
5,060,447 |
|
|
|
5,977,841 |
|
Net loss per share applicable to common stockholders – basic and diluted |
|
$ |
(2.93 |
) |
|
$ |
(2.48 |
) |
|
|
|
|
|
|
|
|
|
|
|
As Previously Reported |
|
|
As Adjusted |
|
|
|
Year ended December 31, |
|
|
Year ended December 31, |
|
|
|
2023 |
|
|
2023 |
|
Numerator: |
|
|
|
|
|
|
Net loss |
|
$ |
(19,028,883 |
) |
|
$ |
(19,028,883 |
) |
Denominator: |
|
|
|
|
|
|
Weighted-average number of common shares outstanding – basic and diluted (restated) |
|
|
5,333,096 |
|
|
|
6,028,210 |
|
Net loss per share applicable to common stockholders – basic and diluted (restated) |
|
$ |
(3.57 |
) |
|
$ |
(3.16 |
) |
|
X |
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- DefinitionTabular disclosure of prior period adjustments to previously issued financial statements including (1) the effect of the correction on each financial statement line item and any per-share amounts affected for each prior period presented (2) the cumulative effect of the change on retained earnings or other appropriate components of equity or net assets in the statement of financial position, as of the beginning of the earliest period presented, and (3) the effect of the prior period adjustments (both gross and net of applicable income tax) on the net income of each prior period presented in the entity's annual report for the year in which the adjustments are made.
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v3.24.2.u1
Going Concern - Additional Information (Details) - USD ($)
|
Jun. 30, 2024 |
May 30, 2024 |
Dec. 31, 2023 |
Jan. 31, 2023 |
Jun. 30, 2021 |
Dec. 31, 2020 |
DisclosureOfGoingConcernLineItems |
|
|
|
|
|
|
Working capital |
$ 4,898,258
|
$ 3,200,000
|
|
|
|
|
Accumulated deficit |
(76,509,968)
|
|
$ (66,900,725)
|
|
|
|
Cash |
3,086,455
|
|
9,165,179
|
|
|
|
Marketable securities |
4,853,559
|
|
$ 4,086,873
|
|
|
|
Accounts payable and accrued expenses |
$ 3,375,063
|
|
|
|
|
|
IPO [Member] |
|
|
|
|
|
|
DisclosureOfGoingConcernLineItems |
|
|
|
|
|
|
Working capital |
|
|
|
|
|
$ 14,600,000
|
January 2023 Offering |
|
|
|
|
|
|
DisclosureOfGoingConcernLineItems |
|
|
|
|
|
|
Working capital |
|
|
|
$ 8,500,000
|
|
|
June 2021 Offering |
|
|
|
|
|
|
DisclosureOfGoingConcernLineItems |
|
|
|
|
|
|
Working capital |
|
|
|
|
$ 41,100,000
|
|
X |
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- DefinitionSum of the carrying values as of the balance sheet date of obligations incurred through that date, including liabilities incurred and payable to vendors for goods and services received, taxes, interest, rent and utilities, compensation costs, payroll taxes and fringe benefits (other than pension and postretirement obligations), contractual rights and obligations, and statutory obligations.
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v3.24.2.u1
Basis of Presentation and Significant Accounting Policies - Additional Information (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Summary Of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Common stock, par value |
$ 0.001
|
|
$ 0.001
|
|
$ 0.001
|
Revenue |
$ 0
|
|
$ 0
|
|
|
Reverse stock split description |
|
|
On June 30, 2023, we effected a reverse stock split at the ratio of 1 post-split share for every 6 pre-split shares.
|
|
|
Research and Development Expense |
3,075,830
|
|
$ 5,827,109
|
|
|
Minimum | Office Equipment |
|
|
|
|
|
Summary Of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Estimated Useful Lives |
|
|
three
|
|
|
Maximum | Office Equipment |
|
|
|
|
|
Summary Of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Estimated Useful Lives |
|
|
five
|
|
|
Vendor [Member] |
|
|
|
|
|
Summary Of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Research and Development Expense |
$ 175,000
|
|
$ 297,000
|
|
|
Payable balance to vendor |
|
|
$ 125,000
|
|
$ 57,000
|
Customer Concentration Risk | Sales Revenue |
|
|
|
|
|
Summary Of Significant Accounting Policies [Line Items] |
|
|
|
|
|
Concentration risk, percentage |
|
100.00%
|
|
100.00%
|
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|
Jun. 30, 2024 |
Dec. 31, 2023 |
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Marketable securities, Amortized cost |
$ 4,854,583
|
$ 4,085,996
|
Fair Value, Recurring [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
1,012,040
|
8,039,024
|
Marketable securities, Amortized cost |
4,853,559
|
4,086,873
|
Fair Value, Recurring [Member] | U.S. Treasury obligations [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Marketable securities, Amortized cost |
4,853,559
|
4,086,873
|
Fair Value, Recurring [Member] | Money Market Funds [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
1,012,040
|
8,039,024
|
Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
1,012,040
|
8,039,024
|
Marketable securities, Amortized cost |
4,853,559
|
4,086,873
|
Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member] | U.S. Treasury obligations [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Marketable securities, Amortized cost |
4,853,559
|
4,086,873
|
Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member] | Money Market Funds [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
1,012,040
|
8,039,024
|
Fair Value, Inputs, Level 3 [Member] | Fair Value, Recurring [Member] |
|
|
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
|
|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
0
|
0
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Marketable securities, Amortized cost |
0
|
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Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
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Marketable securities, Amortized cost |
0
|
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Fair Value, Inputs, Level 3 [Member] | Fair Value, Recurring [Member] | Money Market Funds [Member] |
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Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] |
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|
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|
Cash equivalents and marketable securities measured at their fair value on a recurring basis |
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|
$ 0
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|
6 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Dec. 31, 2023 |
Marketable securities, available-for-sale: |
|
|
Marketable securities, Amortized cost |
$ 4,854,583
|
$ 4,085,996
|
Marketable securities, Unrealized Gain |
0
|
877
|
Marketable securities, Unrealized Loss |
(1,024)
|
0
|
Marketable securities, Fair Value |
4,853,559
|
4,086,873
|
U.S. Treasury obligations |
|
|
Marketable securities, available-for-sale: |
|
|
Marketable securities, Amortized cost |
4,854,583
|
4,085,996
|
Marketable securities, Unrealized Gain |
0
|
877
|
Marketable securities, Unrealized Loss |
(1,024)
|
0
|
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$ 4,086,873
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|
6 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Dec. 31, 2023 |
Gain (Loss) on Securities [Line Items] |
|
|
Unrealized gain |
$ 0
|
$ 877
|
Marketable securities, Unrealized Loss |
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|
0
|
Proceeds from Sale and Maturity of Marketable Securities |
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|
41,100,000
|
Marketable Securities, Realized Gain (Losses) |
0
|
0
|
U.S. treasury debt securities |
|
|
Gain (Loss) on Securities [Line Items] |
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|
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v3.24.2.u1
Equipment and Improvements - Schedule of Equipment and Improvements (Details) - USD ($)
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Property, Plant and Equipment, Gross |
$ 103,825
|
$ 103,825
|
Less: Accumulated depreciation |
43,590
|
30,453
|
Total |
60,235
|
73,372
|
Furniture and office equipment |
|
|
Property, Plant and Equipment, Gross |
86,930
|
86,930
|
IT equipment |
|
|
Property, Plant and Equipment, Gross |
$ 16,895
|
$ 16,895
|
X |
- DefinitionAmount of accumulated depreciation and amortization from plant, property, and equipment and right-of-use asset from finance lease.
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v3.24.2.u1
Supplemental Balance Sheet Information - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($)
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
|
Accrued consulting |
$ 54,298
|
$ 49,395
|
Accrued compensation |
486,956
|
635,451
|
Accrued research and development |
1,482,340
|
1,472,292
|
Accrued other |
10,931
|
102,817
|
Total accrued expenses and other current liabilities |
$ 2,034,525
|
$ 2,259,955
|
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v3.24.2.u1
Stockholders' Equity - Additional Information (Details)
|
|
|
3 Months Ended |
6 Months Ended |
May 20, 2024
USD ($)
$ / shares
shares
|
Feb. 01, 2024
USD ($)
|
Mar. 31, 2023
USD ($)
|
Jun. 30, 2024
USD ($)
Vote
shares
|
Jun. 30, 2023
USD ($)
|
Class Of Stock [Line Items] |
|
|
|
|
|
Votes per each common stock share | Vote |
|
|
|
1
|
|
Common stock shares reserved for issuance |
|
|
|
3,589,232
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs | $ |
|
|
$ 1,000,000
|
$ 3,611,255
|
$ 8,543,037
|
Initial fair value of Warrants | $ |
|
|
$ 1,800,000
|
|
|
Warrant [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Common warrants issued for purchase of common shares |
247,925
|
|
|
|
|
Securities purchase agreements [Member] | Warrant [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Issuance of common stock for services, Shares |
714,527
|
|
|
|
|
Sale of common stock | $ / shares |
$ 1.68
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 0.0001
|
|
|
|
|
Common warrants issued for purchase of common shares |
957,925
|
|
|
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs | $ |
$ 2,200,000
|
|
|
|
|
Securities purchase agreements [Member] | Warrant [Member] | Series A [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 1.68
|
|
|
|
|
Common warrants issued for purchase of common shares |
1,672,452
|
|
|
|
|
Securities purchase agreements [Member] | Warrant [Member] | Series B [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 1.68
|
|
|
|
|
Common warrants issued for purchase of common shares |
1,672,452
|
|
|
|
|
Warrant Inducement Agreement [Member] | Series C [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 1.68
|
|
|
|
|
Common warrants issued for purchase of common shares |
1,229,484
|
|
|
|
|
Warrant Inducement Agreement [Member] | Common Stock |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 1.68
|
|
|
|
|
Common warrants issued for purchase of common shares |
708,500
|
|
|
|
|
Warrant Inducement Agreement [Member] | Common Stock | Series C [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Common warrants issued for purchase of common shares |
708,500
|
|
|
|
|
Warrant Inducement Agreement [Member] | Common Stock | Series D [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Warrants exercise price | $ / shares |
$ 1.68
|
|
|
|
|
Common warrants issued for purchase of common shares |
708,500
|
|
|
|
|
H.C. Wainwright & Co., LLC [Member] | Wainwright Agreement [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Aggregate offering price from sales agent | $ |
$ 50,000
|
$ 5,700,000
|
|
|
|
Agent commission percentage of aggreagate gross proceeds |
|
3.00%
|
|
|
|
Number of shares sold |
|
|
|
315,338
|
|
Net proceeds from agent (Private Placement) | $ |
|
|
|
$ 820,509
|
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Stock-based Compensation - Additional Information (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Stock compensation expense |
$ 30,697
|
$ 124,845
|
$ 84,131
|
$ 248,118
|
Board of Director Member |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Number of stock options granted |
|
|
188,039
|
86,669
|
Stock option, strike price |
$ 2.12
|
$ 2.81
|
$ 2.12
|
$ 2.81
|
Performance-based options, Granted |
|
|
45,000
|
25,000
|
Performance-based options, weighted average strike price |
|
|
$ 2.16
|
$ 1.33
|
Employee |
|
|
|
|
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] |
|
|
|
|
Stock option, aggregate grant date fair value |
$ 359,032
|
$ 338,738
|
$ 359,032
|
$ 338,738
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Stock-Based Compensation - Summary of Stock-Based Compensation Expense for Stock Options Granted to Employees and Non-Employees (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 30,697
|
$ 124,845
|
$ 84,131
|
$ 248,118
|
Research and Development |
|
|
|
|
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] |
|
|
|
|
Total stock-based compensation expense |
(7,706)
|
40,259
|
10,224
|
78,876
|
Selling, General and Administrative |
|
|
|
|
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 38,403
|
$ 84,586
|
$ 73,907
|
$ 169,242
|
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ATM Program (Additional Information) (Details) - USD ($)
|
|
|
3 Months Ended |
6 Months Ended |
May 20, 2024 |
Feb. 01, 2024 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Marketable Securities [Line Items] |
|
|
|
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
$ 1,000,000
|
$ 3,611,255
|
$ 8,543,037
|
H.C. Wainwright & Co., LLC [Member] | Wainwright Agreement [Member] |
|
|
|
|
|
Marketable Securities [Line Items] |
|
|
|
|
|
Number of shares sold |
|
|
|
315,338
|
|
Percentage of Commission from Sale of Shares |
|
3.00%
|
|
|
|
Proceeds from issuance of common stock, pre-funded warrants and warrants, net of issuance costs |
|
|
|
$ 820,509
|
|
H.C. Wainwright & Co., LLC [Member] | Wainwright Agreement [Member] | Common Stock |
|
|
|
|
|
Marketable Securities [Line Items] |
|
|
|
|
|
Common stock Aggregate offering price |
$ 50,000
|
|
|
|
|
Number of shares sold |
|
5,700,000
|
|
|
|
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v3.24.2.u1
Net Loss Per Share - Summary of Calculation of Basic and Diluted Net Loss Per Share applicable to Common Stockholders (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
9 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Mar. 31, 2024 |
Sep. 30, 2023 |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Sep. 30, 2023 |
Dec. 31, 2023 |
Numerator: |
|
|
|
|
|
|
|
|
|
Net loss |
$ (4,959,608)
|
$ (4,649,635)
|
|
$ (5,777,966)
|
$ (4,477,778)
|
$ (9,609,243)
|
$ (10,255,744)
|
|
|
Denominator: |
|
|
|
|
|
|
|
|
|
Weighted average number of common share basic |
7,535,667
|
|
|
|
|
6,939,779
|
|
|
|
Weighted average number of common share diluted |
7,535,667
|
|
|
|
|
6,939,779
|
|
|
|
Net loss per share applicable to common stockholders - basic |
$ (0.66)
|
|
|
|
|
$ (1.38)
|
|
|
|
Net loss per share applicable to common stockholders - diluted |
$ (0.66)
|
|
|
|
|
$ (1.38)
|
|
|
|
As Adjusted |
|
|
|
|
|
|
|
|
|
Numerator: |
|
|
|
|
|
|
|
|
|
Net loss |
|
|
$ (4,595,199)
|
$ (5,777,966)
|
$ (4,477,778)
|
|
$ (10,255,744)
|
$ (14,850,943)
|
$ (19,028,883)
|
Denominator: |
|
|
|
|
|
|
|
|
|
Weighted average number of common share basic |
|
|
6,162,671
|
6,162,280
|
5,582,631
|
|
5,883,895
|
5,977,841
|
6,028,210
|
Weighted average number of common share diluted |
|
|
6,162,671
|
6,162,280
|
5,582,631
|
|
5,883,895
|
5,977,841
|
6,028,210
|
Net loss per share applicable to common stockholders - basic |
|
|
$ (0.75)
|
$ (0.94)
|
$ (0.8)
|
|
$ (1.74)
|
$ (2.48)
|
$ (3.16)
|
Net loss per share applicable to common stockholders - diluted |
|
|
$ (0.75)
|
$ (0.94)
|
$ (0.8)
|
|
$ (1.74)
|
$ (2.48)
|
$ (3.16)
|
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Net Loss Per Share - Summary of Shares Excluded from Calculation of Diluted Net Loss per Share Applicable to Common Stockholders (Details) - shares
|
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Antidilutive shares excluded from calculation of diluted net loss per share |
9,006,245
|
3,973,503
|
Options to Purchase Shares of Stock |
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Antidilutive shares excluded from calculation of diluted net loss per share |
1,020,280
|
835,913
|
Warrants to Purchase Shares of Stock |
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Antidilutive shares excluded from calculation of diluted net loss per share |
7,985,965
|
3,137,590
|
X |
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v3.24.2.u1
v3.24.2.u1
Commitments and Contingencies (Additional Information) (Details) - USD ($)
|
|
|
3 Months Ended |
6 Months Ended |
|
|
Jun. 17, 2024 |
Apr. 18, 2022 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Apr. 26, 2024 |
Dec. 31, 2023 |
Loss Contingencies [Line Items] |
|
|
|
|
|
|
|
|
Right-of-use asset |
|
|
$ 163,762
|
|
$ 163,762
|
|
|
$ 222,227
|
Operating Lease, Liability, Current |
|
|
152,224
|
|
152,224
|
|
|
|
Lease term |
|
3 years
|
|
|
|
|
|
|
Operating Lease, Liability, Noncurrent |
|
|
25,606
|
|
25,606
|
|
|
|
Lease Expense |
|
|
32,296
|
$ 35,296
|
70,591
|
$ 70,591
|
|
|
ShortTerm Lease Payments |
|
|
5,653
|
$ 5,788
|
11,306
|
$ 11,576
|
|
|
Present value of operating lease liabilities |
|
|
177,830
|
|
177,830
|
|
|
|
Prepaid Expenses and Other Current Assets [Member] |
|
|
|
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
|
|
|
Security deposit |
|
|
$ 25,000
|
|
$ 25,000
|
|
|
|
Lexington |
|
|
|
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
|
|
|
Lease Expiration Date |
|
Sep. 30, 2025
|
|
|
|
|
|
|
Lessee, Operating Lease, Discount Rate |
|
|
12.00%
|
|
12.00%
|
|
|
|
Right-of-use asset |
|
|
$ 163,762
|
|
$ 163,762
|
|
|
|
Lessor, Operating Lease, Description |
|
|
|
|
The Office Lease contains escalating payments during the lease period. Upon execution of the Office Lease, the Company prepaid one month of rent and a security deposit, one of which will be held in escrow and credited at the termination of the lease and the other of which will be applied to the first month’s rent.
|
|
|
|
Present value of operating lease liabilities |
|
|
$ 177,830
|
|
$ 177,830
|
|
|
|
Sphaera Agreement [Member] |
|
|
|
|
|
|
|
|
Loss Contingencies [Line Items] |
|
|
|
|
|
|
|
|
Damages sought value |
$ 900,000
|
|
|
|
|
|
|
|
Milestone payments plus interest |
|
|
|
|
|
|
$ 1,625,000
|
|
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v3.24.2.u1
Commitments and Contingencies - Summary of Future minimum lease payments (Details)
|
Jun. 30, 2024
USD ($)
|
Commitments and Contingencies Disclosure [Abstract] |
|
2024 |
$ 75,580
|
2025 |
114,966
|
Total lease payments |
190,546
|
Less: imputed interest |
(12,716)
|
Operating Lease, Liability, Total |
$ 177,830
|
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v3.24.2.u1
Correction of Prior Period Immaterial Error - Schedule of Error Corrections and Prior Period Adjustments (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
9 Months Ended |
12 Months Ended |
Jun. 30, 2024 |
Mar. 31, 2024 |
Sep. 30, 2023 |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Sep. 30, 2023 |
Dec. 31, 2023 |
Error Corrections and Prior Period Adjustments Restatement [Line Items] |
|
|
|
|
|
|
|
|
|
Net loss |
$ (4,959,608)
|
$ (4,649,635)
|
|
$ (5,777,966)
|
$ (4,477,778)
|
$ (9,609,243)
|
$ (10,255,744)
|
|
|
Weighted average number of common share basic |
7,535,667
|
|
|
|
|
6,939,779
|
|
|
|
Weighted average number of common share diluted |
7,535,667
|
|
|
|
|
6,939,779
|
|
|
|
Net loss per share applicable to common stockholders - basic |
$ (0.66)
|
|
|
|
|
$ (1.38)
|
|
|
|
Net loss per share applicable to common stockholders - diluted |
$ (0.66)
|
|
|
|
|
$ (1.38)
|
|
|
|
Previously Reported |
|
|
|
|
|
|
|
|
|
Error Corrections and Prior Period Adjustments Restatement [Line Items] |
|
|
|
|
|
|
|
|
|
Net loss |
|
|
$ (4,595,199)
|
$ (5,777,966)
|
$ (4,477,778)
|
|
$ (10,255,744)
|
$ (14,850,943)
|
$ (19,028,883)
|
Weighted average number of common share basic |
|
|
5,342,337
|
5,226,101
|
4,585,013
|
|
4,918,206
|
5,060,447
|
5,333,096
|
Weighted average number of common share diluted |
|
|
5,342,337
|
5,226,101
|
4,585,013
|
|
4,918,206
|
5,060,447
|
5,333,096
|
Net loss per share applicable to common stockholders - basic |
|
|
$ (0.86)
|
$ (1.11)
|
$ (0.98)
|
|
$ (2.09)
|
$ (2.93)
|
$ (3.57)
|
Net loss per share applicable to common stockholders - diluted |
|
|
$ (0.86)
|
$ (1.11)
|
$ (0.98)
|
|
$ (2.09)
|
$ (2.93)
|
$ (3.57)
|
As Adjusted |
|
|
|
|
|
|
|
|
|
Error Corrections and Prior Period Adjustments Restatement [Line Items] |
|
|
|
|
|
|
|
|
|
Net loss |
|
|
$ (4,595,199)
|
$ (5,777,966)
|
$ (4,477,778)
|
|
$ (10,255,744)
|
$ (14,850,943)
|
$ (19,028,883)
|
Weighted average number of common share basic |
|
|
6,162,671
|
6,162,280
|
5,582,631
|
|
5,883,895
|
5,977,841
|
6,028,210
|
Weighted average number of common share diluted |
|
|
6,162,671
|
6,162,280
|
5,582,631
|
|
5,883,895
|
5,977,841
|
6,028,210
|
Net loss per share applicable to common stockholders - basic |
|
|
$ (0.75)
|
$ (0.94)
|
$ (0.8)
|
|
$ (1.74)
|
$ (2.48)
|
$ (3.16)
|
Net loss per share applicable to common stockholders - diluted |
|
|
$ (0.75)
|
$ (0.94)
|
$ (0.8)
|
|
$ (1.74)
|
$ (2.48)
|
$ (3.16)
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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Inhibikase Therapeutics (NASDAQ:IKT)
過去 株価チャート
から 7 2024 まで 8 2024
Inhibikase Therapeutics (NASDAQ:IKT)
過去 株価チャート
から 8 2023 まで 8 2024