UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16
UNDER THE SECURITIES EXCHANGE ACT OF 1934
For the date of October 27, 2023
Commission File Number 001-39124
Centogene N.V.
(Translation of registrant's name into English)
Am Strande
7
18055 Rostock
Germany
(Address of principal executive offices)
Indicate by check mark whether the registrant files
or will file annual reports under cover of Form 20-F or Form 40-F.
Form 20-F..X.. Form 40-F.....
Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ___
Indicate by check mark if the registrant is submitting
the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ____
Centogene N.V.
Variation Agreement to Joint Venture Agreement
On October 23, 2023, Centogene N.V. (the
“Company”) entered into a variation agreement (the “Variation Agreement”) to the joint venture
agreement (the “Joint Venture Agreement”) that the company entered into on June 26, 2023 with Pharmaceutical
Investment Company (“PIC”), a closed joint stock company incorporated pursuant to the laws of Saudi Arabia and
trading as “Lifera” and a wholly-owned subsidiary of the Public Investment Fund based in Riyadh. The Joint Venture Agreement was
summarized in the Company’s Current Report on Form 6-K filed on June 27, 2023 and filed therewith as Exhibit 99.2 thereto.
Pursuant to the Variation Agreement, amongst other things, the Company and PIC have agreed to extend the long-stop date under the
Joint Venture Agreement to November 30, 2023 and PIC has waived certain conditions to closing thereunder. The full text of the
Variation Agreement is attached as Exhibit 99.1 to this Current Report on Form 6-K and is incorporated herein by reference.
Convertible Loan Agreement and Ancillary Agreements
On October 26, 2023, PIC and the Company entered into a Loan Agreement,
Preemptive Rights Agreement and Registration Rights Agreement, each substantially in the forms agreed and summarized in the Company’s
Current Report on Form 6-K filed on June 27, 2023. In addition, and also on October 26, 2023, the Company, PIC and Oxford Finance LLC
(“Oxford”) entered into a Subordination Agreement pursuant to which the obligations incurred by the Company under
the Loan Agreement are subordinated to the Company’s obligations under the existing Loan and Security Agreement by and between
the Company and Oxford, originally dated January 31, 2022.
The full text of the form of Loan Agreement is attached as Exhibit
99.2 to this Current Report on Form 6-K and is incorporated herein by reference. The full text of the Preemptive Rights Agreement is
attached as Exhibit 99.3 to this Current Report on Form 6-K and is incorporated herein by reference. The full text of the Registration
Rights Agreement is attached as Exhibit 99.4 to this Current Report on Form 6-K and is incorporated herein by reference. The full text
of the Subordination Agreement is attached as Exhibit 99.5 to this Current Report on Form 6-K and is incorporated herein by reference.
In connection with the Loan Agreement, on October 26, 2023, certain
existing shareholders of the Company entered into a right of first offer agreement with PIC (the “ROFO Agreement”).
The full text of the ROFO Agreement is attached as Exhibit 99.6 to this Current Report on Form 6-K and is incorporated herein by reference.
Signatures
Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
Date: October 27, 2023
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CENTOGENE N.V. |
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By: |
/s/ Jose Miguel Coego Rios |
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Name: |
Jose Miguel Coego Rios |
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Title: |
Chief Financial Officer |
Exhibit Index
+The Company has omitted
portions of the exhibits attached hereto pursuant to Item 601(b)(10)(iv) of Regulation S-K on the basis that the Company customarily
and actually treats that information as private or confidential and the omitted information is not material.
Exhibit 99.1
Execution Copy
VARIATION AGREEMENT
TO JOINT VENTURE AGREEMENT
THIS VARIATION
AGREEMENT (this “Agreement”) is dated 23 October, 2023 and is made by and among:
| (1) | PHARMACEUTICAL
INVESTMENT COMPANY, a closed joint stock company incorporated pursuant to the laws of
the Kingdom of Saudi Arabia, with commercial registration number 1010698585, having its registered
address located at Alra’idah Digital City, Building MU04, Al Nakhil District, P.O.
Box 6847, Riyadh 11452, KSA (“PIC”); and |
| (2) | CENTOGENE
N.V., a public company (naamloze vennootschap) organized under the laws of the
Kingdom of the Netherlands and registered with the Chamber of Commerce (Kamer van Koophandel)
under registration number 72822872, having its head office address at Am Strande 7, 18055
Rostock, Germany (“NV”), each a Party and together the Parties. |
Background
| (A) | The Parties
entered into a joint venture agreement on 26 June 2023 (the “JVA”). |
| (B) | In accordance
with Clause 22.8 of the JVA, the purpose of this Agreement is to (i) extend the Long Stop
Date to a new date and (ii) revise the completion mechanism under the JVA. |
Agreed Terms
| 1. | TERMS DEFINED
IN THE AGREEMENT |
In this
Agreement, and unless otherwise defined herein, capitalized terms defined in the JVA and used in this Agreement have the meaning set
out in the JVA. The rules of interpretation set out in Clause 1.2 of the JVA shall apply to this Agreement as if set out herein.
| 2.1 | PIC hereby
waives the conditions specified under Clause 2.1(c) of the JVA (“the Articles of
Association of the Company (“Articles”) being in Agreed Form, having been
approved by MOC”), Clause 2.1(g) of the of the JVA (“the necessary corporate
and regulatory authorizations to incorporate the Company having been obtained by the Parties”)
and Clause 2.1(j) of the JVA (“any other step required by the Applicable Law and
the Governmental Authorities to incorporate the Company in the Kingdom having been completed
in accordance with the terms of this Agreement”). |
| 2.2 | Clause 2.5
of the JVA is hereby amended and restated in its entirety as follows: |
“2.5 Subject
to the following steps occurring in chronological order, as soon as reasonably practicable after the last of the Conditions has been
satisfied or waived, the Shareholders shall procure that the following actions shall be carried out:
| a) | execution
by PIC and NV of the Loan Agreement, Registration Rights Agreement and Pre-emptive Rights
Agreement; |
Addendum to the Joint Venture Agreement between Pharmaceutical Investment Company and Centogene N.V.
| b) | execution
by PIC, DPE Deutsche Private Equity Gesellschaft mbH, Careventures Fund II S.C.Sp, and TVM
Life Science Innovation I, L.P. of the ROFO Agreement; |
| c) | advance
by PIC of the loan being made under the Loan Agreement in accordance with its terms; |
| d) | execution
of the Articles in Agreed Form before a competent notary public in the Kingdom; |
| e) | issuance
of the commercial registration certificate evidencing the incorporation of the Company; |
| f) | execution
by the Company and NV of the Commercial Agreements; and |
| g) | opening
of a bank account in the name of the Company and deposit of the share capital of the Company,
with each of PIC and NV contributing the nominal value in SAR set out against the applicable
Shareholder’s name, and in exchange for the number of shares similarly identified,
in Clause 4.1 (Share Capital of the Company).” |
| 2.3 | The definition
of “Long Stop Date” under Clause 1.1 of the JVA is hereby amended and
restated in its entirety as follows: |
“Long
Stop Date” means 30 November 2023 or such later date as the Shareholders may agree in writing.”
| 3.1 | Except as set
out in Clause 2.1 of this Agreement, the JVA shall continue in full force and effect
and each Party agrees to be bound by its terms in all respects (as amended herein). |
| 3.2 | This Agreement
shall be read together and form part of the JVA and to the extent of any inconsistency between
the provisions of the JVA and this Agreement, the provisions of this Agreement shall prevail.
Clauses 16, 19 and 22 of the JVA shall apply mutatis mutandis to this letter. |
* * *
Addendum to the Joint Venture Agreement between Pharmaceutical Investment Company and Centogene N.V.
Page 2 of 3
This Agreement
has been executed in two (2) counterparts, of which PIC and NV have kept one copy each.
For and on behalf of THE PHARMACEUTICAL
INVESTMENT COMPANY |
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Signed by: |
/s/ Ibrahim Abdulrahman I Aljuffali |
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Name: Dr. Ibrahim Abdulrahman
I Aljuffali |
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Title: Chairman |
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For and on behalf
of CENTOGENE N.V |
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Signed by: |
/s/ Kim Stratton |
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Name: Kim Stratton |
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Title: Chief Executive Officer |
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By: |
/s/ Miguel Coego |
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Name: Miguel Coego |
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Title: Chief Financial
Officer, Legal & IT |
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Addendum to the Joint Venture Agreement between Pharmaceutical Investment Company and Centogene N.V.
Page 3 of 3
Exhibit 99.2
Execution Version
LOAN AGREEMENT
dated as
of October 26, 2023
by and among
CENTOGENE N.V.,
as Borrower,
and
PHARMACEUTICAL
INVESTMENT COMPANY,
as Lender,
Table of Contents
Page
Section 1. |
|
Definitions |
1 |
Section 2. |
|
Rules
of Construction |
8 |
Section 3. |
|
The
Loan |
9 |
(a) |
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Generally |
9 |
(b) |
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The
Closing |
9 |
Section 4. |
|
Representations,
Warranties and Covenants of the Borrower |
10 |
(a) |
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Due
Organization, Valid Existence; Power to Perform Obligations |
10 |
(b) |
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Status
of Underlying Shares |
10 |
(c) |
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Listing
of Underlying Shares |
10 |
(d) |
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Subsidiaries |
11 |
(e) |
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SEC
Documents; Financial Information |
11 |
(f) |
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Absence
of Certain Changes |
11 |
(g) |
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[Reserved] |
13 |
(h) |
|
Litigation |
13 |
(i) |
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Compliance
with Laws; Permits |
13 |
(j) |
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Taxes |
13 |
(k) |
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Enforceability
of Transaction Documents |
14 |
(l) |
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Non-Contravention |
14 |
(m) |
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No
Consents |
14 |
(n) |
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Authorization,
Execution and Delivery of the Transaction Documents |
14 |
(o) |
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Investment
Company Act |
14 |
(p) |
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Compliance |
14 |
(q) |
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Title
to Properties |
15 |
(r) |
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Intellectual
Property |
15 |
(s) |
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Environmental
Matters |
18 |
(t) |
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Insurance
Coverage |
18 |
(u) |
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[Reserved] |
18 |
(v) |
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Tax
Representations |
18 |
(w) |
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[Reserved] |
18 |
( x) |
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Cybersecurity;
Data Protection |
19 |
(y) |
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Compliance
with Health Care Laws |
20 |
(z) |
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Nasdaq |
22 |
(aa) |
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Securities
Act Matters |
22 |
(bb) |
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Employment
Matters |
22 |
(cc) |
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[Reserved] |
23 |
(dd) |
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Employee
Benefit Matters |
23 |
(ee) |
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Anti-Corruption |
25 |
(ff) |
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Sanctions
and Trade Controls |
26 |
Section 5. |
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Representations,
Warranties and Covenants of Lender |
26 |
(a) |
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Authorization,
Execution and Delivery of This Agreement |
26 |
(b) |
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Non-Contravention |
26 |
(c) |
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Acknowledgement of Risks; Investment
and Transaction Sophistication |
26 |
(d) |
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No Registration |
26 |
(e) |
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Restricted Securities |
27 |
Section 6. |
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Further
Covenants of the Parties |
28 |
(a) |
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Right to Nominate Lender Director |
28 |
(b) |
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Restrictions on Transfer |
29 |
(c) |
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Authorized Shares |
29 |
(d) |
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Use of Proceeds |
29 |
(e) |
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Additional Documentation |
30 |
(f) |
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Indebtedness |
30 |
(g) |
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Rights Upon Conversion |
30 |
Section 7. |
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Conditions
to Obligations of the Borrower and Lender |
31 |
(a) |
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Conditions to the Obligations of
the Borrower |
31 |
(b) |
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Conditions to Lender’s Obligations |
31 |
Section 8. |
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The
Release Time |
32 |
Section 9. |
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Miscellaneous |
32 |
(a) |
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Survival |
32 |
(b) |
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Entire Agreement; Waiver; Amendment |
32 |
(c) |
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Assignability |
32 |
(d) |
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Further Instruments and Acts |
32 |
(e) |
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Waiver of Jury Trial |
33 |
(f) |
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Governing Law |
33 |
(g) |
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Arbitration |
33 |
(h) |
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Counterparts |
33 |
(i) |
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Notices |
33 |
(j) |
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Binding Effect |
35 |
(k) |
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Severability |
35 |
(l) |
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No Third Party Beneficiaries |
35 |
(m) |
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Interpretation |
35 |
(n) |
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Confidentiality |
35 |
Schedules and
Exhibits
Schedule A: Loan Commitment Amount |
SA-1 |
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Schedule
4(d): Subsidiaries |
SA-2 |
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Schedule
4(e): SEC Documents |
SA-3 |
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Schedule
4(f): Absence of Certain Changes |
SA-4 |
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Schedule
4(h): Litigation |
SA-5 |
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Schedule
4(q)(i): Title to Properties |
SA-6 |
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Schedule
4(q)(ii): Leased Location Notices |
SA-7 |
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Schedule
4(q)(iii): Other Notices |
SA-8 |
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Schedule
4(r)(ii): IP Status and Claims |
SA-9 |
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Schedule
4(r)(iii): Intellectual Property |
SA-10 |
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Schedule
4(r)(iv): Current Company IP |
SA-11 |
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Schedule
4(r)(vi): Intellectual Property Assignments |
SA-12 |
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Schedule
4(cc): Employee Benefit Plans |
SA-13 |
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Schedule
4(cc)(v): Employee Payments |
SA-14 |
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Schedule
4(cc)(vi): Pension Commitments |
SA-15 |
Exhibit A: Terms and Conditions of Loan |
A-1 |
LOAN AGREEMENT
This
LOAN AGREEMENT (as the same may be amended, supplemented, restated or otherwise modified from time to time, and including all
Schedules and Exhibits hereto and thereto, this “Agreement”), dated as of October 26, 2023, between CENTOGENE N.V.,
a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (the “Borrower”),
and PHARMACEUTICAL INVESTMENT COMPANY (“Lender”).
WHEREAS,
the Borrower has requested that Lender make available to the Borrower the convertible term loan financing facility described herein.
Lender is willing to extend such convertible term loan to the Borrower under the terms and conditions set forth herein and in Exhibit
A.
THEREFORE,
in consideration of the agreements, provisions and covenants herein contained, the Borrower and Lender each agree as follows.
Section 1.
Definitions.
“Affiliate”
has the meaning set forth in Rule 144 as in effect on the Closing Date.
“Agreement”
has the meaning set forth in the preamble of this Agreement.
“Anti-Corruption
Laws” means all applicable laws, rules and regulations relating to bribery or corruption, including the U.S. Foreign Corrupt
Practices Act of 1977, as amended (“FCPA”), the UK Bribery Act 2010, the anti-corruption laws of the country of incorporation
of the Borrower, and any other applicable anti-corruption or anti-bribery laws.
“Articles
of Association” means the Borrower’s articles of association (as supplemented, amended or restated).
“Benefit
Plan” means each “employee benefit plan” (as defined under Section 3(3) of ERISA, whether or not subject
to ERISA) and any other plan, policy, or agreement providing current or deferred compensation, severance, change-in-control payments,
equity awards, fringe benefits, or other compensation or benefits, regardless of whether the plan, policy, or arrangement is written
or unwritten or is funded or unfunded, which the Borrower or any ERISA Affiliate sponsors or maintains or to which the Borrower has had
any obligation to contribute or any other liability, whether actual or contingent.
“Borrower”
has the meaning set forth in the preamble of this Agreement.
“Business
Day” means any day other than a Saturday, Sunday or any other day on which banking institutions in New York City, United States,
Riyadh, Saudi Arabia or Frankfurt am Main, Germany are authorized or required by Law or executive order to close or be closed.
“Business
Employee” means each employee of either the Borrower or any Subsidiary of the Borrower.
“Capital
Shares” has the meaning set forth in the Terms and Conditions.
“Closing”
has the meaning set forth in Section 3(b)(i).
“Closing
Date” has the meaning set forth in Section 3(b)(i).
“Closing
Legal Opinion” has the meaning set forth in Section 4(u).
“Code”
means the Internal Revenue Code of 1986, as amended.
“Common
Shares” means the common shares, nominal value €0.12 per share, of the Borrower.
“Company
Business” means the business of the Borrower and its Subsidiaries as currently conducted or proposed to be conducted.
“Conversion
Price” has the meaning set forth in the Terms and Conditions.
“Copyright
License” means any written agreement between the Borrower or any of its Subsidiaries, on the one hand, and a third party, on
the other hand, pursuant to which the Borrower or any of its Subsidiaries grants rights under its Copyrights included in Intellectual
Property, or such third party grants the Borrower or any of its Subsidiaries rights under such third party’s Copyrights.
“Copyrights”
means all copyrights, whether registered or unregistered, held pursuant to the laws of the United States of America, any State thereof,
or of any other country.
“Current
Company IP” has the meaning set forth in Section 4(r)(iv).
“Data
Protection Obligations” has the meaning set forth in Section 4(x).
“Environmental
Laws” has the meaning set forth in Section 4(s).
“ERISA”
means the Employee Retirement Income Security Act of 1974, as amended.
“ERISA
Affiliate” means any entity (other than the Borrower or any of its Subsidiaries) that, together with the Borrower or any of
its Subsidiaries, is treated as a single employer under Section 414(b), (c), (m) or (o) of the Code.
“Exchange
Act” means the Securities Exchange Act of 1934, as amended.
“Financial
Statements” has the meaning set forth in Section 4(e).
“FDA”
means the United States Food and Drug Administration, or any successor thereto.
“Government
Official” means any officer or employee of a foreign governmental authority or any department, agency, or instrumentality thereof,
or of a public international organization, or any person acting in an official capacity for or on behalf of any such foreign governmental
authority or department, agency, or instrumentality, or for or on behalf of any such
public
international organization, or any political party, party official, or candidate thereof, excluding officials of the governments of the
United States, the several states thereof, any local subdivision of any of them or any agency, department or unit of any of the foregoing.
“Governmental
Entity” means (a) any supranational, national, federal, state, provincial, municipal, local or foreign government, governmental
authority, regulatory or administrative agency, governmental commission, department, board, bureau, agency, instrumentality, any court,
tribunal, arbitrator, mediator or other governmental official, authority or instrumentality and (b) any entity to whom a Governmental
Entity has assigned or delegated any authority or oversight responsibilities, including any notified body accredited, designated, licensed,
authorized or approved to assess and certify the conformity of a medical device (including in vitro diagnostic medical device) with the
requirements of the In Vitro Diagnostic Medical Devices Directive 98/79/EC, the In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746,
and applicable harmonized standards.
“Health
Care Laws” has the meaning set forth in Section 4(y)(i).
“HIPAA”
has the meaning as set forth in Section 4(x).
“IFRS”
means the International Accounting Standards as issued by the International Accounting Standards Board.
“Indebtedness”
means, at any specified time, without duplication, any of the following indebtedness of any Person (whether or not contingent and including,
without limitation, any and all principal, accrued and unpaid interest, prepayment premiums or penalties, related expenses, commitment
and other fees, sale or liquidity participation amounts, reimbursements, indemnities and other amounts which would be payable in connection
therewith): (a) any obligations of such Person for borrowed money or in respect of loans or advances (whether or not evidenced by bonds,
debentures, notes, or other similar instruments or debt securities); (b) any obligations of such Person as lessee under any lease or
similar arrangement required to be recorded as a capital lease in accordance with IFRS; (c) all liabilities of such Person under or in
connection with letters of credit or bankers’ acceptances, performance bonds, sureties or similar obligations that have been drawn
down, in each case, to the extent of such draw; (d) all liabilities of such Person arising out of interest rate and currency swap arrangements
and any other arrangements designed to provide protection against fluctuations in interest or currency rates; and (e) any liability or
obligation of others guaranteed by, or secured by any Lien on the assets of, such Person.
“Intellectual
Property” means all Copyrights, Trademarks, Patents, trade secrets, inventions and mask works owned or controlled by the Borrower
and its Subsidiaries, together with the rights to sue for past, present and future infringement of any of the foregoing and the goodwill
associated therewith.
“Lender
Nominee” has the meaning set forth in Section 6(a)(i).
“IT
Systems” has the meaning set forth in Section 4(x).
“IRS”
means the United States Internal Revenue Service.
“License
Agreements” means any Copyright License, Patent License and Trademark License.
“JAMS”
has the meaning set forth in Section 10(g).
“JAMS
Rules” has the meaning set forth in Section 10(g).
“Joint
Venture” has the meaning set forth in Section 6(d).
“Law”
means any statute, law, ordinance, rule, regulation, code, approval, license, Permit or Order, in each case, of any Governmental Entity.
“Lien”
is a claim, mortgage, deed of trust, levy, charge, pledge, security interest or other encumbrance of any kind, whether voluntarily incurred
or arising by operation of Law or otherwise against any assets or property.
“Loan”
means the meaning set forth in Section 3(a). To the extent all or any portion of the Loan made on the Closing Date is assigned
by Lender to a Permitted Transferee (or Permitted Transferees), the use of the term “Loan” herein shall refer collectively
to the Loan Commitments held by all Permitted Transferees.
“Loan
Commitment” means, with respect to any Lender, the amount set forth opposite such Lender’s name on Schedule A hereto
under the caption “Loan Commitment Amount”, as amended from time to time to reflect any permitted and effective assignments
and as such amount may be reduced, terminated or converted pursuant to this Agreement.
“Material
Adverse Effect” means any change, event, effect, state of facts or occurrence arising after the date of this Agreement that,
individually or in the aggregate with any other change, event, effect, state of facts, or occurrence, has had or would reasonably be
expected to have a material adverse effect on (a) the assets, liabilities, results of operations, financial condition or business of
the Borrower and its Subsidiaries taken as a whole, or (b) the ability of the Borrower to perform its obligations under the Transaction
Documents, in each case excluding any effect resulting from (A) any failure, in it of itself, by NV to maintain compliance with the minimum
bid price, minimum stockholders’ equity or minimum market value of publicly-held securities requirement of The Nasdaq Stock Market
LLC (it being understood that the facts or causes underlying or contributing to such failure, including, without limitation, any decline
in stockholders’ equity, may be considered in determining whether a Material Adverse Change has occurred unless otherwise excluded
pursuant to any of the other clauses of this definition) or (B) any “going concern” or similar qualification in the audit
report prepared in connection with the financial statements for the NV and its Controlled Affiliates.
“Maximum
Number of Underlying Shares” has the meaning set forth in Section 4(b).
“Nasdaq”
means The Nasdaq Stock Market LLC.
“Nomination
Right Condition” has the meaning set forth in Section 6(a)(i).
“Open
Source Licenses” has the meaning set forth in Section 4(r)(xi).
“Order”
means any order, judgment, injunction, decree, writ, stipulation, determination or award, in each case, entered by or with any Governmental
Entity.
“Ordinary
Course of Business” means, with respect to any Person, the usual and ordinary course of normal day-to-day operations of such
Person, consistent (in scope, manner, amount and otherwise) with the such Person’s past practices through the date of this Agreement.
“Oxford
Loan” has the meaning set forth in Section 6(f).
“Oxford
Subordination Agreement” means that certain Subordination Agreement, dated as of the Closing Date, between Oxford Finance LLC
and the Lender, and acknowledged by the Borrower and certain of its Subsidiaries, as the same may be amended, supplemented, restated
or replaced from time to time, including any replacement subordination agreement required by the lenders providing financing that replaces
or refinances the Oxford Loan.
“Patent
License” means any written agreement between the Borrower or any of its Subsidiaries, on the one hand, and a third party, on
the other hand, pursuant to which the Borrower or any of its Subsidiaries grants rights under its Patents included in Intellectual Property,
or such third party grants the Borrower or any of its Subsidiaries rights under such third party’s Patents.
“Patents”
means all letters patent, or rights corresponding thereto, in the United States of America or in any other country, all registrations,
recordings, reissues, extensions, or renewals, thereof, and all applications for letters patent, or rights corresponding thereto, in
the United States of America or any other country.
“Payor”
means any health care insurance and other similar programs under which the Borrower or any of its Subsidiaries are directly or indirectly
receiving payments, including any federal or state healthcare program, Medicare, Medicaid, the TRICARE program, the Veterans Health Administration,
private or commercial insurance programs, third-party administrators, preferred provider organizations, managed care organizations, health
maintenance organizations, health plans, self-insured health plans, or any fiscal intermediary or contractor of any of the foregoing.
“Pension
Commitments” has the meaning set forth in Section 4(cc)(vi).
“Permit”
means all certifications, registrations, licenses, permits, franchises, approvals, clearances, exemptions, authorizations or consents
issued by any Governmental Entity, or declarations of conformity, necessary for or used in the conduct or operation of the Borrower’s
or any of its Subsidiaries’ business.
“Permitted
Liens” means (a) Liens for Taxes, assessments or other governmental charges not yet due and payable, or that are being contested
in good faith by appropriate proceedings and for which adequate reserves have been established on the Financial Statements in accordance
with IFRS, (b) any mechanics’, carriers’, workers’, repairers’ and other similar Liens arising or incurred in
the Ordinary Course of Business for obligations that are not overdue or are being contested in good faith by appropriate proceedings,
(c) zoning, entitlement, building and other land use regulations imposed by any Governmental Entity, (d) Liens and restrictions on real
property
(including easements, covenants, rights of way and similar restrictions of record) that (i) are matters of record, (ii) would be disclosed
by a current, accurate survey of such real property or (iii) do not materially interfere with the present uses of such real property,
(e) Liens arising under worker’s compensation, unemployment insurance, social security, retirement and similar legislation,
(f) non-exclusive Intellectual Property licenses granted in the Ordinary Course of Business and (g) Liens securing Term Loans (as defined
in the Oxford Loan) in an aggregate principal amount not to exceed $50,000,000 (or at any time prior to an Insolvency Proceeding (as
defined in the Oxford Subordination Agreement) of Borrower or any of its material Subsidiaries, such larger amount with the prior written
consent of the Lender and from and after such Insolvency Proceeding such consent shall not be required) and all other Obligations (as
defined in the Oxford Loan) in respect of the Oxford Loan. For the sake of clarity, the aggregate principal amount of the Oxford Loan
shall not include interest, Lenders’ Expenses, the Prepayment Fee, the Final Payment, the payment under the Success Fee Agreement
(as such terms are defined in the Oxford Loan) or other amounts due to the collateral agent and the lenders in respect of the Oxford
Loan.
“Permitted
Transferees” has the meaning set forth in Section 6(b).
“Person”
means an individual, corporation, partnership, limited liability company, joint venture, trust or unincorporated organization or a government
or agency or political subdivision thereof.
“Personal
Data” has the meaning set forth in Section 4(x).
“PIK
Interest Payment” has the meaning set forth in the Terms and Conditions.
“Preemptive
Rights Agreement” means that certain Preemptive Rights Agreement, dated as of the Closing Date, between the Borrower and the
Lender, as the same may be amended or supplemented from time to time.
“Principal
Amount” means the principal amount of the Loan issued on the Closing Date, as such amount may be increased pursuant to the
PIK Interest Payment as provided in the Terms and Conditions.
“Process”
or “Processing” or “Processed” means, with respect to data, the access, use, collection, processing,
storage, hosting, alteration, transfer, retrieval, transmittal, disclosure, disposal, dissemination or combination of such data.
“Registration
Rights Agreement” means that certain Registration Rights Agreement, dated as of the Closing Date, between the Borrower and
Lender, as the same may be amended or supplemented from time to time, in accordance with its terms.
“Release
Time” has the meaning set forth in Section 8.
“Representatives”
means a Persons’ Affiliates, employees, agents, consultants, accountants, attorneys or financial advisors.
“ROFO
Agreement” means that certain ROFO Agreement, dated as of the Closing Date, between the Lender, DPE Deutsche Private Equity
GmbH, Careventures Fund II S.C.Sp, and TVM Life Science Innovation I, L.P., as the same may be amended or supplemented from time to time.
“Safety
Notices” has the meaning set forth in Section 4(y)(ii).
“Sanctions”
means economic or financial sanctions or trade embargoes imposed, administered or enforced from time to time by the United States, the
European Union or any member state thereof, the United Kingdom, the United Nations or any governmental institution or agency of any of
the foregoing, including the United States’ Office of Foreign Assets Control (“OFAC”) or the United States Department
of State, the United Kingdom’s Office of Financial Sanctions Implementation or His Majesty’s Treasury or the United Nations
Security Council.
“Sanctioned
Country” means, at any time, a country or territory that is itself the target of comprehensive Sanctions (as of the date of
this Agreement, Cuba, Iran, North Korea, Syria, the Crimea region of Ukraine, the so-called Donetsk People’s Republic, and the
so-called Luhansk People’s Republic).
“Sanctioned
Person” means any Person that is the target of Sanctions, including (a) any Person listed in any Sanctions-related list of
designated Persons maintained by OFAC or the U.S. Department of State, the United Nations Security Council, the European Union, any Member
State of the European Union, or the United Kingdom; (b) any Person operating, organized, or resident in a Sanctioned Country; (c) the
government of a Sanctioned Country or the Government of Venezuela; or (d) any Person 50% or more owned or controlled by any such Person
or Persons or acting for or on behalf of such Person or Persons.
“SEC”
means the Securities and Exchange Commission.
“SEC
Documents” means all reports, schedules, registration statements, proxy statements and other documents (including all amendments,
exhibits and schedules thereto) filed by the Borrower with the SEC on or after January 1, 2021.
“Securities
Act” means the Securities Act of 1933, as amended.
“Security
Incident” has the meaning set forth in Section 4(x).
“Security
Risk Analysis” has the meaning set forth in Section 4(x).
“Subsequent
Lender Shareholders Agreement” has the meaning set forth in Section 6(g).
“Subsidiary”
means, when used with reference to a party, any Person, whether incorporated or unincorporated, of which an amount of the equity, voting
securities, other voting ownership or voting partnership interests of which is sufficient to elect at least a majority of its board of
directors or other governing body (or, if there are no such voting interests, 50% or more of the Equity Securities of which) is owned
directly or indirectly by such party or any other Subsidiary of such party, or such party is a general partner or serves in a similar
capacity.
“Supervisory
Board of Directors” means the supervisory board (raad van commissarissen) of the Borrower.
“Take-Private
Transaction” means any transaction or event in which the Common Shares of Borrower (or replacement equity interest in any surviving
entity, acquirer successor, or transferee, as applicable (or the parent entity thereof)) are no longer listed on Nasdaq or any other
national securities exchange.
“Tax”
and “Taxes” means any present or future tax, duty, levy, impost, assessment, deduction, withholding (including United
States backup withholding), fees or other charge in the nature of taxes (including penalties and interest and other similar liabilities
related thereto) imposed by any Governmental Entity.
“Tax
Return” means any return, report or similar filing (including the attached schedules) filed or required to be filed with respect
to Taxes (and any amendments thereto), including any information return, claim for refund or declaration of estimated Taxes.
“Terms
and Conditions” means the terms and conditions of the Loan attached in the form of Exhibit A hereto.
“Trade
Controls” means (a) all applicable trade, export control, import, and antiboycott laws and regulations imposed, administered,
or enforced by the U.S. government, including the Arms Export Control Act (22 U.S.C. § 1778), the International Emergency Economic
Powers Act (50 U.S.C. §§ 1701–1706), Section 999 of the Internal Revenue Code, the U.S. customs laws at Title 19 of the
U.S. Code, the Export Control Reform Act of 2018 (50 U.S.C. §§ 4801-4861), the International Traffic in Arms Regulations (22
C.F.R. Parts 120–130), the Export Administration Regulations (15 C.F.R. Parts 730-774), the U.S. customs regulations at 19 C.F.R.
Chapter 1, and the Foreign Trade Regulations (15 C.F.R. Part 30); and (b) all applicable trade, export control, import, and antiboycott
laws and regulations imposed, administered or enforced by any other country, except to the extent inconsistent with U.S. law.
“Trademark
License” means any written agreement between the Borrower or any of its Subsidiaries, on the one hand, and a third party, on
the other hand, pursuant to which the Borrower or any of its Subsidiaries grants rights under its Trademarks included in Intellectual
Property, or such third party grants the Borrower or any of its Subsidiaries rights under such third party’s Trademarks.
“Trademarks”
means all trademarks (registered, common law or otherwise) and any applications in connection therewith, including registrations, recordings
and applications in the United States Patent and Trademark Office or in any similar office or agency of the United States of America,
any State thereof or any other country or any political subdivision thereof.
“Transaction
Documents” means, collectively, this Agreement (including the Terms and Conditions attached hereto), the Registration Rights
Agreement, the Preemptive Rights Agreement, the ROFO Agreement and the Oxford Subordination Agreement.
“Transfer”
means any direct or indirect sale, transfer, hypothecation, assignment, gift, bequest or disposition by any other means, whether for
value or no value and whether voluntary or involuntary. The term “Transferred” shall have a correlative meaning.
“U.S.
Person” means a “U.S. person” as such term is defined in Rule 902(k) of Regulation S under the Securities Act.
“Underlying
Shares” means the Common Shares issuable upon conversion of the Loan.
Section 2.
Rules of Construction. For purposes of this Agreement:
(a)
“or” is not exclusive;
(b)
“including” means “including without limitation”;
(c)
“will” expresses a command;
(d)
words in the singular include the plural and in the plural include the singular, unless the context requires otherwise;
(e)
“herein,” “hereof” and other words of similar import refer to this Agreement as a whole and not to any
particular Section or other subdivision of this Agreement, unless the context requires otherwise;
(f)
references to currency mean the lawful currency of the United States of America, unless the context requires otherwise; and
(g)
the exhibits, schedules and other attachments to this Agreement are deemed to form part of this Agreement.
Section 3.
The Loan.
(a) Generally.
Subject to the other terms of this Agreement, Lender hereby agrees to make to Borrower a Loan on the Closing Date in an original aggregate
principal amount equal to Lender’s Loan Commitment (the “Loan”). Lender’s obligation to fund the Loan
shall be limited to Lender’s Loan Commitment Amount. The Loan shall be funded in one advance on the Closing Date.
(b) The
Closing.
(i) Closing
Date and Location. The closing of the Loan pursuant to this Agreement (the “Closing”) will take place virtually
through electronic transfer, or at such physical location as may be agreed upon by the parties hereto, at 10:00 a.m., New York City time,
on the later of (1) such date on which the conditions to Closing set forth in Section 7 are satisfied or waived; and (2)
such other time and place as the Borrower and Lender may agree (such later date, the “Closing Date”); provided
that if the Closing Date has not occurred on or prior to November 30, 2023, this Agreement shall automatically terminate unless the
parties otherwise agree in writing.
(ii) Loan
Proceeds. Subject to satisfaction of the applicable conditions precedent specified in this Agreement, at or prior to 9:30 a.m., New
York City time, on the Closing Date, Lender agrees to make funds available to the Borrower, by wire transfer to the account designated
by the Borrower at least five (5) Business Days prior to the Closing Date, equal to the aggregate Loan Commitment Amount.
(iii)
Lender Records. The Loan made by Lender, including the amounts of principal and interest thereon, shall be evidenced in
the records of Lender and shall be prima facie evidence, absent obvious error, of the existence and amounts of the Advances, principal,
interest and other obligations under the Transaction Documents recorded therein; provided that the failure of Lender to maintain
such records or any error therein shall not in any manner affect the obligation of the Borrower to repay the Loan in accordance with
the terms of this Agreement.
(iv) Payments.
The Borrower shall repay the Loan in accordance with Article 2 of the Terms and Conditions.
(v) Interest. From and following the Closing Date, the Loan shall bear interest as set forth in Article 2 of the Terms and
Conditions.
Section 4.
Representations, Warranties and Covenants of the Borrower. The Borrower represents
and warrants to Lender and covenants that:
(a) Due
Organization, Valid Existence; Power to Perform Obligations. The Borrower is duly organized and validly existing as a public company
with limited liability (naamloze vennootschap) under the laws of the Netherlands, with full power and authority to conduct its
business as it is currently being conducted and to own or lease and use its properties and assets. The Borrower has full power and authority
to enter into the Transaction Documents and perform all of its obligations hereunder and thereunder.
(b) Status
of Underlying Shares. Subject to the terms of this Agreement, the Loan will be convertible into Common Shares (together, if applicable,
with cash in lieu of any fractional Common Share). The Borrower’s authorized share capital (“maatschappelijk kapitaal”)
is EUR 9,480,000 which consists of 79,000,000 Common Shares with a nominal value of EUR 0.12 and as of June 12, 2023, 27,865,752 Common
Shares were issued and outstanding. Except for the securities described in the foregoing sentence or otherwise disclosed to the Lender
immediately prior to the Closing Date, there are not issued, reserved for issuance or outstanding (i) any equity securities of the Borrower
or its Subsidiaries, (ii) any securities convertible into or exchangeable or exercisable for equity securities of the Borrower or its
Subsidiaries or (iii) any warrants, calls, options or other rights to acquire from the Borrower or its Subsidiaries any equity securities
or securities convertible into or exchangeable or exercisable for equity securities of the Borrower or its Subsidiaries (in each case,
other than equity securities held by the Borrower or any of its Subsidiaries). The Borrower will, at all times while the Loan is outstanding,
(i) not propose at any general meeting of the Borrower’s shareholders any reduction of the authorized share capital (“maatschappelijk
kapitaal”) of the Borrower such that the authorized share capital would be insufficient to provide a number of Common Shares
for issuance upon conversion of the Loan equal to the initial maximum number of such shares issuable upon conversion
(assuming
conversions are settled by the delivery of a number of Common Shares equal to the product of (x) the Principal Amount of the Loan (expressed
in thousands) and (y) the initial Conversion Price (the “Maximum Number of Underlying Shares”)), and (ii) will otherwise
use its reasonable best efforts to ensure that the authorized share capital (“maatschappelijk kapitaal”) of the Borrower
is sufficient to provide for the Maximum Number of Underlying Shares to be issued upon conversion of the Loan in accordance with the
terms of the applicable Transaction Documents. When the Underlying Shares are issued upon conversion of the Loan in accordance with the
terms of the applicable Transaction Documents, such Underlying Shares will be validly issued, fully paid and non-assessable (meaning
that the holder of a Common Share shall not by reason of merely being such a holder be subject to assessment or calls by the Company
or its creditors for further payment on such Common Share), and the issuance of any such Underlying Shares will not be subject to any
preemptive or similar rights. To the extent the Borrower delivers Common Shares held in its treasury in settlement of the conversion
of the Loan, each reference in this Agreement to the issuance of Underlying Shares in connection therewith will be deemed to include
such delivery, mutatis mutandis.
(c) Listing
of Underlying Shares. At or before the Closing, the Borrower will have submitted to Nasdaq an Application for Listing of Additional
Shares with respect to the listing of the Underlying Shares. The Borrower shall provide confirmation to Lender when the Underlying Shares
are listed with Nasdaq. The Borrower will use its commercially reasonable efforts to maintain the listing of the Underlying Shares for
so long as the Common Shares are then so listed.
(d) Subsidiaries.
The Borrower’s Subsidiaries consist of all the entities listed on Schedule 4(d). The Borrower, directly or indirectly,
owns of record and beneficially, free and clear of all Liens (except for Liens securing Indebtedness under the Oxford Loan), all of the
issued and outstanding capital stock or equity interests of each of its Subsidiaries. All of the issued and outstanding capital stock
or equity interests of the Borrower’s Subsidiaries has been duly authorized and validly issued, and in the case of corporations,
is fully paid and non-assessable (meaning that the holder of a share or other equity interest in a Subsidiary
of the Borrower shall not by reason of merely being such a holder be subject to assessment or calls by the relevant Subsidiary or its
creditors for further payment on such share). There are no outstanding rights, options, warrants, preemptive rights, conversion
rights, rights of first refusal or similar rights for the purchase or acquisition from any of the Borrower’s Subsidiaries of any
securities of such Subsidiaries nor are there any commitments to issue or execute any such rights, options, warrants, preemptive rights,
conversion rights or rights of first refusal.
(e) SEC
Documents; Financial Information. Except as set forth on Schedule 4(e), since January 1, 2021, the Borrower has timely filed
(i) all annual reports (including all amendments, exhibits and schedules thereto) and (ii) all other reports and other documents (including
all amendments, exhibits and schedules thereto), in each case required to be filed by the Borrower with the SEC pursuant to the Exchange
Act and the Securities Act. As of their respective filing dates, such SEC Documents complied in all material respects with the requirements
of the Securities Act, the Exchange Act and the rules and regulations of the SEC thereunder applicable to such SEC Documents, and as
of their respective dates none of the SEC Documents contained any untrue statement of a material fact or omitted to state a material
fact required to be stated therein or necessary in order to make the statements therein, in light of the
circumstances
under which they were made, not misleading. The financial statements of the Borrower included in the SEC Documents (the “Financial
Statements”) comply as of their respective dates in all material respects with applicable accounting requirements and the rules
and regulations of the SEC with respect thereto (except as may be indicated in the notes thereto), and present fairly in all material
respects as of their respective dates the consolidated financial position of the Borrower and its Subsidiaries as at the dates thereof
and the consolidated results of their operations and their consolidated cash flows for each of the respective periods, all in conformity
with IFRS (except as may be indicated in such Financial Statements or the notes thereto).
(f) Absence
of Certain Changes. (i) From December 31, 2022 through the date hereof, the Borrower and each of its Subsidiaries has conducted its
business in the Ordinary Course of Business and (ii) except as set forth in Schedule 4(f), from December 31, 2022 through the
date hereof, there has not been:
(1)
any material change in the assets, liabilities, financial condition or operating results of the Borrower or its Subsidiaries,
except for (A) changes in the Ordinary Course of Business or (B) any changes that the Borrower’s annual report on Form 20-F for
the year ended December 31, 2022 discloses have occurred or are reasonably expected to occur;
(2)
any declaration or payment by the Borrower or its Subsidiaries of any dividend, or any authorization or payment by the Borrower
or its Subsidiaries of any distribution, on any of the capital stock of the Borrower or such Subsidiary, or any redemption, cancellation
or repurchase by the Borrower or any such Subsidiary of any securities of the Borrower or any such Subsidiary;
(3)
any adoption of any amendment to, or other modification of, the constituent documents of the Borrower or any of its Subsidiaries;
(4)
any incurrence of material Indebtedness, whether assumed, guaranteed or endorsing the obligations of any Person, except for the
Oxford Loan;
(5)
any issuance, sale, pledge, disposal of, Lien or other transfer of any equity securities, securities convertible, exchangeable
or exercisable into equity securities, or warrants, options or other rights to acquire equity securities, of the Borrower or any of its
Subsidiaries (except pursuant to any ordinary course equity compensation or incentive plan (including any employee stock ownership plan,
or other compensation agreements or arrangements));
(6)
any (A) increase in the compensation or benefits of any of the directors or officers of the Borrower or any of its Subsidiaries,
except as may be required under existing Benefit Plans or applicable Law, (B) enter into, adopt, amend or terminate any Benefit Plan
of the Borrower or any of its Subsidiaries, (C) grant or increase any severance, retention or termination pay to any current or former
director or officer, or increase benefits payable thereto under any existing
severance
or termination pay policies, (D) take any action to accelerate the vesting or payment of any compensation or benefit, or to fund or otherwise
secure any obligations under any Benefit Plan, (E) hire or terminate any director or officer of the Borrower or any of its Subsidiaries
other than for cause, or (F) enter into any collective bargaining agreement or into negotiations or discussions with any union;
(7)
any material change in any method of accounting practice other than those required by IFRS;
(8)
any transfer, sale, assignment or other disposition of, or lease or exclusive license of, any material property or assets of the
Borrower or any of its Subsidiaries other than in the Ordinary Course of Business;
(9)
any material damage, destruction or loss, whether or not covered by insurance, to any material assets or properties of the Borrower
or its Subsidiaries;
(10)
any waiver, not in the Ordinary Course of Business, by the Borrower or any of its Subsidiaries of a material right or of a material
debt owed to it;
(11)
any satisfaction or discharge of a material claim or Lien or repayment of any material Indebtedness by the Borrower or any of
its Subsidiaries, except in the Ordinary Course of Business;
(12)
any change or amendment to the Borrower’s Articles of Association, or termination of or material amendment to any material
contract of the Borrower or any of its Subsidiaries;
(13)
any entrance into, renewal, modification or revision of any contract with any officer or director of the Borrower or its Subsidiaries,
other than contracts related to the employment or employee benefits of such Persons;
(14)
any material acquisition, disposition or similar transaction entered into by the Borrower or any of its Subsidiaries other than
in the Ordinary Course of Business; or
(15)
any other event, occurrence, development or condition that, to the knowledge of the Borrower, has had or would reasonably be expected
to have a Material Adverse Effect.
(g) [Reserved].
(h) Litigation. Except as set forth on Schedule 4(h), there is no material litigation or proceeding with or by any
Governmental Entity pending or, to the knowledge of the Borrower, threatened in writing, against the Borrower or any of its Subsidiaries
or affecting any of the business, operations, properties or assets of the Borrower or any of its Subsidiaries. Neither the
Borrower
nor any of its Subsidiaries is subject to any material Order that is expressly applicable to the Borrower or any of its Subsidiaries.
(i) Compliance
with Laws; Permits. The Borrower and its Subsidiaries are in material compliance with all applicable Laws. The Borrower and its Subsidiaries
have obtained and maintained in all material respects, all Permits, including any Permits required pursuant to any applicable Health
Care Laws, and all of such Permits are in full force and effect. The Borrower and each of its Subsidiaries have fulfilled and performed
in all material respects all of their respective obligations with respect to all applicable Permits, and, to the knowledge of the Borrower,
no event has occurred which allows, or after notice or lapse of time would allow, revocation or termination thereof or result in any
other impairment of the rights of the holder of any such Permit.
(j) Taxes.
The Borrower and each of its Subsidiaries has filed all Tax Returns required to be filed within the applicable periods for such filings
(with due regard to any extension) and has paid all Taxes required to be paid.
(k) Enforceability
of Transaction Documents. Each of the Transaction Documents to which the Borrower is a party constitutes a valid and binding agreement
or instrument of the Borrower, enforceable against the Borrower in accordance with its terms, except as enforceability may be limited
by applicable bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or similar Laws affecting creditors’ rights
generally or by equitable principles relating to enforceability, including principles of commercial reasonableness, good faith and fair
dealing, regardless of whether enforcement is sought in a proceeding at Law or in equity.
(l) Non-Contravention.
The execution, delivery and performance by the Borrower of the Transaction Documents, including the borrowing of the Loan and the issuance
of the Underlying Shares upon conversion of the Loan in the manner contemplated by the Transaction Documents, and the consummation by
the Borrower of the other transactions contemplated by this hereby and thereby, will not (i) contravene in any material respect any Law
binding on, or any Order of any Governmental Entity (including the rules of Nasdaq) applicable to, the Borrower or any of its Subsidiaries;
(ii) constitute a material breach or violation or result in a default under any loan agreement, mortgage, lease or other agreement or
instrument to which the Borrower or any of its Subsidiaries is a party or by which any of them is bound; or (iii) constitute a breach
or violation or result in a default under the organizational documents of the Borrower or any of its Subsidiaries.
(m) No
Consents. No consent, approval, authorization, Order, license, registration or qualification of or with any Governmental Entity or
other Person is required for the execution, delivery and performance by the Borrower of its obligations under the Transaction Documents
and the consummation of the transactions contemplated hereby and thereby, except (i) such as have been obtained or made (or will, at
the Closing, have been obtained or made) and except for any filings as may be required (and will have been obtained or made in each case
when and as required) under the Exchange Act, by Nasdaq or, if relevant, the Dutch Trade Register (Kamer van Koophandel) and (ii)
where the failure to do so could not reasonably be expected to have a Material Adverse Effect.
(n) Authorization,
Execution and Delivery of the Transaction Documents. The Transaction Documents have been duly authorized, executed and delivered
by the Borrower.
(o) Investment Company Act. The Borrower is not and, after giving effect to the transactions contemplated by the Transaction
Documents, will not be an “investment company” within the meaning of the Investment Company Act of 1940, as amended, and
the rules and regulations of the SEC thereunder.
(p) Compliance.
The Borrower and each of its Subsidiaries, taken as a whole, is not (i) in material default under or in material violation of (and no
event has occurred that has not been waived that, with notice or lapse of time or both, would result in a default by the Borrower or
any of its Subsidiaries under), nor has the Borrower or any of its Subsidiaries received notice of a claim that it is in material default
under or that it is in material violation of, any indenture, loan or credit agreement or any other material agreement or instrument to
which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), or (ii)
in material violation of any Order.
(q) Title
to Properties. Except as set forth on Schedule 4(q)(i) or as would not reasonably be expected to have a Material Adverse Effect,
the Borrower and its Subsidiaries (i) have good and marketable title to all material real properties and all other material tangible
properties and assets owned by them, in each case free from Liens and defects, except for Permitted Liens, (ii) hold any leased real
or personal property under valid, subsisting and enforceable leases with which the Borrower and its Subsidiaries are in material compliance,
and (iii) use all real property leased by the Borrower or any of its Subsidiaries in all material respects in compliance with all applicable
Laws. Except as set forth on Schedule 4(q)(ii), in the past three years from the date hereof, the Borrower and its Subsidiaries
have not received written notice of any material violation or default under any real property lease. Except as set forth on Schedule
4(q)(iii), in the past three years from the date hereof, the Borrower and its Subsidiaries have not received any written notice of
existing, pending or threatened (A) condemnation proceedings affecting the any leased real property or (B) zoning, building code or other
moratorium proceedings, or similar matters, which would reasonably be expected to materially and adversely affect the ability to operate
the Borrower’s leased real properties as currently operated in the Ordinary Course of Business.
(r) Intellectual Property.
(i) The
Borrower and its Subsidiaries own, possess, license or have other rights to use, the Intellectual Property that is necessary or material
for use in connection with the Company Business.
(ii) Except
as described on Schedule 4(r)(ii), (A) each of the material Copyrights, Trademarks and Patents included in the Intellectual Property
that the Borrower and its Subsidiaries own or exclusively in-license are valid, subsisting and enforceable, (B) no material Copyrights,
Trademarks and Patents included in the Intellectual Property has been adjudged invalid or unenforceable, in whole or in part, and (C)
no written claim has been made to the Borrower or any of its Subsidiaries that any
material
Copyrights, Trademarks and Patents included in the Intellectual Property violates the rights of any third party.
(iii) Schedule
4(r)(iii) sets forth a true, correct and complete list of each of the Patents, registered Trademarks and registered Copyrights included
in the Intellectual Property that the Borrower and its Subsidiaries own or exclusively in-license, and material License Agreements under
which the Borrower and its Subsidiaries in-license Intellectual Property from third parties (other than shrink-wrap software licenses
or off-the-shelf commercial software licenses), together with application or registration numbers, as applicable, in each case as of
the Closing Date. The Borrower or any of its Subsidiaries is not in material breach of, nor has the Borrower or any of its Subsidiaries
failed to perform any material obligations under, any of the foregoing License Agreements and, to the Borrower’s knowledge, no
third party to any such License Agreement is in material breach thereof or has failed to perform any material obligations thereunder.
(iv) Except
as set forth on Schedule 4(r)(iv), each item of Intellectual Property that the Borrower or its Subsidiaries own or exclusively
in-license that, individually or taken together with any other Intellectual Property, is material to the Company Business, taken as a
whole (collectively, the “Current Company IP”) (1) no such item of Current Company IP has lapsed, expired, been cancelled
or invalidated or become abandoned or unenforceable, and (2) no written notice has been received challenging the inventorship or ownership,
or relating to any lapse, expiration, invalidation, abandonment or unenforceability, of any such item of Current Company IP.
(v) The Borrower or any of its Subsidiaries possesses valid title to the Current Company IP for which it is listed as the owner or
co-owner; and (ii) there are no Liens (other than Permitted Liens) on any Current Company IP.
(vi) To
the Borrower’s knowledge, there are no published patents, patent applications, articles or prior art references that are not owned
or controlled by the Borrower or any of the Subsidiaries that would reasonably be expected to materially adversely affect the Company
Business.
(vii) Except as set forth on Schedule 4(r)(vi), each Person who has or has had any rights in or to owned Current Company IP or
any trade secrets owned by the Borrower or any of its Subsidiaries, including each inventor named on the Patents within such owned Current
Company IP filed by the Borrower or any of its Subsidiaries, has executed an agreement assigning his, her or its entire right, title
and interest in and to such owned Current Company IP and such trade secrets, and the inventions, improvements, ideas, discoveries, writings,
works of authorship, information and other intellectual property embodied, described or claimed therein, to the stated owner thereof,
and to the knowledge of the Borrower, no such Person has any contractual or other obligation that would preclude or conflict with such
assignment or the exploitation of the Company Business or entitle such Person to ongoing payments.
(viii) There
are no maintenance, annuity or renewal fees that are currently overdue beyond their allotted grace period for any of the Current Company
IP that is owned by or exclusively in-licensed to the Borrower or any of its Subsidiaries, nor have any applications or registrations
therefor lapsed or become abandoned, been cancelled or expired, other than those that the Borrower or its Subsidiaries have abandoned,
cancelled or allowed to expired for strategic purposes. To the Borrower’s knowledge, there are no maintenance, annuity or renewal
fees that are currently overdue beyond their allotted grace period for any of the Current Company IP that is non-exclusively licensed
to the Borrower or any of its Subsidiaries, nor have any applications or registrations therefor lapsed or become abandoned, been cancelled
or expired, in each case, that would materially impact the exploitation of the Company Business.
(ix) Except
as set forth on Schedule 4(r)(ix), there is no pending or, to the knowledge of the Borrower, threatened in writing action, suit,
proceeding or claim by any Person that the Company Business or the business of its Subsidiaries as now conducted infringes or otherwise
violates any intellectual property rights of another Person. To the knowledge of the Borrower, there is no existing infringement by another
Person of any material Intellectual Property.
(x) The Borrower and its Subsidiaries have taken all commercially reasonable security measures (assessed by reference to what is commercially
reasonable in the life sciences industry) to protect the secrecy, confidentiality, nature and value of all of its Intellectual Property
used or held for use by the Borrower or any of its Subsidiaries that are material to the Company Business, where the value of such Intellectual
Property is contingent upon maintaining the secrecy or confidentiality thereof. All licenses or other material agreements under which
the Borrower is granted material rights to Intellectual Property are, to the knowledge of the Borrower, in full force and effect and,
to the knowledge of the Borrower, there is no material default by any other Person thereto. The Borrower has no reason to believe that
the licensors under such licenses and other agreements do not have and did not have all requisite power and authority to grant the rights
to the Intellectual Property purported to be granted thereby. The consummation of the transactions contemplated hereby and by the other
Transaction Documents will not result in the alteration, loss, impairment of or restriction on the Borrower’s or any of its Subsidiaries’
ownership or right to use any Intellectual Property that is material to the conduct of the Borrower’s business as currently conducted.
The Borrower and its Subsidiaries have the right to freely transfer, license or assign the Intellectual Property necessary or material
in the operation or conduct of the Company Business, without condition, restriction or payment of any kind (other than license payments
in the Ordinary Course of Business) to any other Person, and the Borrower and its Subsidiaries own or have the right to use, pursuant
to valid licenses, all software development tools, library functions, compilers and all other third-party software and other items that
are material to the Company Business, except customary covenants in inbound license agreements and equipment leases where the Borrower
or any of its Subsidiary is the licensee or lessee.
(xi) No
material software used by the Borrower or any of its Subsidiaries are subject to an open-source or similar license (including but not
limited to the General Public License, Lesser General Public License, Mozilla Public License, or Affero
License)
(collectively, “Open Source Licenses”) in a manner that would cause such software or other materials to have to be
(A) distributed to third parties at no charge or a minimal charge (royalty-free basis); (B) licensed to third parties to modify, make
derivative works based on, decompile, disassemble, or reverse engineer; or (C) used in a manner that does require disclosure or distribution
in source code form.
(xii) The
Borrower has not disclosed, delivered, licensed or made available to any Person or agreed or obligated itself to disclose, deliver, license
or make available to any Person, or permitted the disclosure or delivery to any escrow agent or other Person of, any company source code,
other than disclosures to employees and independent contractors who are individuals not companies involved in the development of products
on behalf of the Borrower under binding written agreements that prohibit use or disclosure except in the performance of services for
the Borrower. No event has occurred, and no circumstance or condition exists, that (with or without notice or lapse of time, or both)
will, or would reasonably be expected to, result in the disclosure, delivery or license by the Borrower of any company source code, other
than disclosures to employees and individual independent contractors involved in the development of the Borrower’s products under
binding written agreements that prohibit use or disclosure except in the performance of services for the Borrower. Without limiting the
foregoing, neither the execution of this Agreement nor any of the transactions contemplated by this Agreement will result in a release
from escrow or other delivery to a Person of any company source code.
(xiii) The
software included in Current Company IP and owned by the Borrower does not contain any disabling mechanisms or protection features which
are designed to disrupt, disable, harm or otherwise impede in any manner the operation of, or provide unauthorized access to, a computer
system or network or other device on which such software is stored or installed or damage or destroy any data or file without the user’s
consent. The Borrower has implemented procedures that are both reasonable and consistent with standard industry practices designed to
ensure its software is free from viruses, disabling or other malicious codes.
(s) Environmental
Matters. Neither the Borrower nor any of its Subsidiaries is in material violation of any Law or Order of any Governmental Entity,
domestic or foreign, relating to the use, disposal or release of hazardous or toxic substances or relating to the protection or restoration
of the environment or human exposure to hazardous or toxic substances (collectively, “Environmental Laws”), has released
any hazardous substances regulated by Environmental Law on to any real property that it owns or operates, or has received any written
notice or claim it is liable for any off-site disposal or contamination pursuant to any Environmental Laws, except in each case as would
not reasonably be expected to have a Material Adverse Effect; and to the knowledge of the Borrower, there is no pending or threatened
in writing investigation that would reasonably be expected to lead to such a claim.
(t) Insurance
Coverage. The Borrower and each of its Subsidiaries (i) maintain insurance covering their respective properties, operations, personnel
and businesses as the Borrower reasonably deems adequate relative to customary industry practice, (ii) the Borrower reasonably believes
such insurance insures against such losses and risks in accordance with
customary
industry practice to protect the Borrower and the Subsidiaries and their respective businesses and which is commercially reasonably for
the current conduct of their respective businesses, and (iii) maintains such insurance in full force on the date hereof.
(u) [Reserved].
(v) Tax
Representations. There are no material U.S. federal, state, county, local or non-U.S. Taxes due and payable by the Borrower and its
subsidiaries that have not been timely paid. There are no material accrued and unpaid U.S. federal, state, county, local or non-U.S.
Taxes of the Borrower or its subsidiaries that are due, whether or not assessed or disputed. There have been no examinations or audits
of any tax returns or reports of the Borrower or its subsidiaries by any applicable U.S. federal, state, local or non-U.S. Governmental
Entity. The Borrower and its subsidiaries have duly and timely filed all material U.S. federal, state, county, local and non-U.S. tax
returns required to have been filed by them, and there are in effect no waivers of applicable statutes of limitations with respect to
Taxes of the Borrower or its subsidiaries for any year.
(w) [Reserved].
(x) Cybersecurity; Data Protection. The information technology assets and equipment, computers, systems, networks, hardware,
software, websites, applications, and databases owned by, or licensed or leased to, the Borrower and its Subsidiaries and used in the
business of the Borrower and its Subsidiaries (collectively, “IT Systems”) are adequate for, and operate and perform
as required in all material respects in connection with the operation of the business of the Borrower and its Subsidiaries as currently
conducted and, to the knowledge of the Borrower, are free and clear of all material bugs, errors, defects, Trojan horses, time bombs,
malware and other corruptants. The Borrower and its Subsidiaries have implemented and maintained appropriate and commercially reasonable
controls, policies, procedures, safeguards and other technical and organizational measures necessary to maintain and protect their confidential
information and the integrity, continuous operation, redundancy and security of all IT Systems and data (including all personal, personally
identifiable, sensitive, confidential or regulated data (including protected health information) (“Personal Data”))
Processed in connection with their businesses as currently conducted. The Borrower and its Subsidiaries have taken commercially reasonable
steps in accordance with industry standard practices (including, without limitation, implementing and monitoring compliance with adequate
measures with respect to technical and physical security) to protect Personal Data Processed by or on behalf of the Borrower or any of
its Subsidiaries. There have been no breaches, violations, outages or unauthorized uses of or accesses to the IT Systems or Personal
Data in the possession, custody or control of the Borrower or any of its Subsidiaries, nor any incidents under internal review or investigations
relating to the same, including any alleged “breach” as defined in 45 C.F.R. § 164.402 or successful “security
incident” (as defined in 45 C.F.R. § 164.304) with respect to “protected health information” (as defined in 45
C.F.R. § 160.103) (each, a “Security Incident”), except which would not, individually or in the aggregate, reasonably
be expected to be material to the Borrower and its Subsidiaries, taken as a whole. The Borrower and its Subsidiaries have made all notifications
to patients, customers or individuals required to be made by the Borrower and its Subsidiaries under applicable Data Protection Obligations
arising out of or relating to any event of unauthorized access to or disclosure or acquisition of any Personal Data by any Person
of
which the Borrower has knowledge. Except as would not, individually or in the aggregate, reasonably be expected to be material to the
Borrower and its Subsidiaries, taken as a whole, the Borrower and its Subsidiaries are presently, and since January 1, 2021, have been
in compliance with (i) all applicable Laws relating to the Processing of data, data privacy, data security, data breach notification,
and the cross-border transfer of Personal Data (including without limitation, the Health Insurance Portability and Accountability Act
of 1996, as amended by the Health Information Technology for Economic and Clinical Health Act, and the regulations promulgated thereunder
(“HIPAA”), the General Data Protection Regulation EU 2016/679, the German Federal Data Protection Act, the ePrivacy
Directive and national implementing and supplementing laws in the European Economic Area and United Kingdom, the Kingdom of Saudi Arabia’s
National Data Management Office’s Interim Regulations on Personal Data Protection) and all applicable Orders and Laws of any Governmental
Entity; (ii) internal and external privacy policies; and (iii) applicable industry standards and contractual obligations applicable to
the Borrower and its Subsidiaries relating to the privacy and security of IT Systems and Personal Data (including the Payment Card Industry
Data Security Standard) (collectively, clauses (i) - (iii), the “Data Protection Obligations”). The
Borrower and its Subsidiaries have obtained written agreements from all subcontractors to which the Borrower or any of its Subsidiaries
have provided or disclosed Personal Data to the extent required by the applicable Data Protection Obligations, and to the knowledge of
the Borrower, no such subcontractor is in material breach of any such agreement. The Borrower and its Subsidiaries have in effect all
required business associate contracts (as such term is defined under HIPAA) that satisfy the requirements of HIPAA in all material respects,
such agreements permit the Borrower or its Subsidiary to operate the business of the Borrower and its Subsidiaries as it is presently
conducted, and the Borrower and its Subsidiaries are not in material breach of any such agreements, and to the knowledge of the Borrower,
no such business associate is in material breach of any such agreements. The Borrower and its Subsidiaries, with respect to their business,
have undertaken all necessary surveys, audits, inventories, reviews, analyses and/or assessments (including any necessary risk assessments
and risk analyses) of all areas of its business and operations required by the Data Protection Obligations, including security risk analyses
that meet the standards set forth at 45 C.F.R. § 164.308(a)(1)(ii)(A) (each, a “Security Risk Analysis”), and
have addressed and remediated all material risks identified in each Security Risk Analysis. Neither the Borrower nor any of its Subsidiaries
has received any written notification of or written complaint regarding non-compliance in any material respect with any Data Protection
Obligation. There is no pending, or to the knowledge of the Borrower, threatened in writing, action, suit or proceeding by or before
any Governmental Entity, authority or body alleging non-compliance in any material respect with any Data Protection Obligation. Except
as would not, individually or in the aggregate, reasonably be expected to be material to the Borrower and its Subsidiaries, taken as
a whole, the Borrower and its Subsidiaries have made all disclosures to patients, relatives, customers or other individuals required
by applicable Laws and no such disclosures have been inaccurate or in violation of any applicable Laws. The Borrower and its Subsidiaries
have adopted and published privacy notices and policies that accurately describe the privacy practices of the Borrower and its Subsidiaries
and complied with those notices and policies, and no such notices or disclosures have been inaccurate, misleading or deceptive. The Borrower
and its Subsidiaries have all necessary authority, rights, consents and authorizations to Process any Personal Data maintained by or
for the Borrower and its Subsidiaries to the extent
required
in connection with the operation of the Borrower and its Subsidiaries’ business as currently conducted.
(y) Compliance with Health Care Laws.
(i) The
Borrower and its Subsidiaries are and, since January 1, 2021, have been in material compliance with all applicable Health Care Laws (as
defined below). For purposes of this Agreement, “Health Care Laws” means the Federal Food, Drug, and Cosmetic Act
(21 U.S.C. § 301 et seq.), the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. § 263a et seq.), the Anti-Kickback
Statute (42 U.S.C. Section 1320a-7b(b)), the Civil Monetary Penalties Law (42 U.S.C. § 1320a-7a), the Civil False Claims Act
(31 U.S.C. Section 3729 et seq.), the criminal False Claims Law (42 U.S.C. § 1320a-7b(a)), all criminal laws relating to health
care fraud and abuse, including but not limited to 18 U.S.C. Sections 286, 287, 1035, 1347, 1349 and the health care fraud criminal provisions
under HIPAA, the exclusion laws (42 U.S.C. § 1320a-7), the Physician Payments Sunshine Act (42 U.S.C. Section 1320a-7h), the
21st Century Cures Act (Pub. L. 114-255), the Medicare statute (Title XVIII of the Social Security Act), the Medicaid statute (Title
XIX of the Social Security Act) and any other Law or regulation governing or pertaining to a government healthcare program, and any and
all other state, local or federal health care Laws and the regulations promulgated pursuant to such Laws, each as amended from time to
time, as well as any foreign equivalent Laws in respect of any of the foregoing, including, in the case of the European Union, any such
equivalent Laws of the European Union and the corresponding implementing national rules of each member state thereof, and the German
Genetic Diagnostic Act (Gendiagnostikgesetz, “GenDG”) and for the Kingdom of Saudi Arabia, the Ministry of Health’s
published regulations, policies and guidance. Since January 1, 2021, neither the Borrower nor its Subsidiaries has received any FDA Form
483, notice of adverse finding, warning letter, untitled letter or other correspondence or notice from the FDA, or other written notice
of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any Governmental Entity
alleging a material violation of any Health Care Laws, and, to the Borrower’s knowledge, no such claim, action, suit, proceeding,
hearing, enforcement, investigation, arbitration or other action is threatened in writing. The Borrower and its Subsidiaries have filed,
maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions and supplements or
amendments as required by any Health Care Laws, and all such reports, documents, forms, notices, applications, records, claims, submissions
and supplements or amendments were complete and accurate on the date filed in all material respects (or were corrected or supplemented
by a subsequent submission). None of the Borrower or its Subsidiaries is a party to or has ongoing reporting or disclosure obligations
pursuant to any corporate integrity agreements, deferred or non-prosecution agreements, monitoring agreements, consent decrees, settlement
orders, plans of correction or similar agreements with or imposed by any Governmental Entity. None of the Borrower, its Subsidiaries
or its respective employees, officers or directors, or, to the knowledge of the Borrower, agents, has been excluded, suspended or debarred
from participation in any U.S. federal health care program or, to the knowledge of the Borrower, is subject to an inquiry, investigation,
proceeding or other similar action from a Governmental Entity that could reasonably be expected to result in debarment, suspension, or
exclusion.
(ii) (A)
There have been no material recalls, field notifications, field corrections, market withdrawals or replacements, warnings, “dear
doctor” letters, investigator notices, safety alerts or other notice of action relating to an alleged lack of safety, efficacy,
or regulatory compliance of the Borrower’s products (“Safety Notices”), and (B) to the Borrower’s knowledge,
there are no facts that would be reasonably likely to result in a material Safety Notice with respect to the Borrower’s products,
or a termination or suspension of marketing or testing of any of the Borrower’s products.
(iii) All
clinical or preclinical studies, tests, trials or investigations that have been or are being conducted by or on behalf of, or sponsored
by, the Borrower or any of its Subsidiaries, or in which the Borrower’s or any of its Subsidiaries’ products or product candidates
have participated, and which have been or will be submitted to the FDA or other Governmental Entity in connection with applications for
Permits, were and, if still pending, are being conducted in compliance in all material respects with all applicable Health Care Laws.
No investigational device exemption or other allowance to commence a clinical trial or investigation filed with or submitted to the FDA
or other Governmental Entity by or on behalf of the Borrower or any of its Subsidiaries has been terminated or suspended, and neither
the FDA nor any applicable Governmental Entity has commenced, or to the Borrower’s knowledge, threatened in writing to initiate,
any action to place a clinical hold order on, or otherwise adversely modify, terminate, delay or suspend, any proposed or ongoing clinical
investigation conducted or proposed to be conducted by or on behalf of the Borrower or any of its Subsidiaries and, to the Borrower’s
knowledge, there are no reasonable grounds for the same.
(iv) The
Borrower and each of its Subsidiaries meet all applicable Payor requirements and conditions of participation and are a party to valid
participation or other agreements required for payment by such Payors in all material respects. All billing, claims, reporting and documentation
practices of the Borrower and its Subsidiaries are in compliance and have been in compliance with all Health Care Laws and legally enforceable
Payor requirements in all material respects. Neither the Borrower nor any of its Subsidiaries has billed, received or retained any payment
or reimbursement in violation of applicable Health Care Laws or legally enforceable Payor requirements in any material respects. There
are no pending audits, recoupments, appeals, or challenges in excess of $500,000 with respect to any billings or claims submissions.
No audit, investigation, validation review or program integrity review related to the Borrower or any of its Subsidiaries has been conducted
by any Payor or Governmental Entity since January 1, 2021 which, if determined adversely to the Borrower or any of its Subsidiaries,
would, individually or in the aggregate, reasonably be expected to be material to the Borrower and its Subsidiaries, taken a whole.
(z) Nasdaq.
As of the date hereof, the Borrower’s Common Shares are listed on Nasdaq. Schedule 4(z) sets forth the grounds (or potential
grounds) on which Nasdaq may delist the Borrower’s Common Shares as to which the Borrower is aware as of the date hereof.
(aa) Securities
Act Matters. Assuming the accuracy of the representations and warranties of Investor, the issuance of the Underlying Shares pursuant
to this Agreement is exempt from the registration requirements of the Securities Act.
(bb) Employment
Matters.
(i) Neither
the Borrower nor any of its Subsidiaries is or has ever been bound by any union contract or collective bargaining agreement and no labor
union or works council or similar labor organization or representative body represents any Business Employee. There is no material activity
or proceeding by any labor union or representative thereof to organize any Business Employee. There are no controversies, strikes, slowdowns,
work stoppages or any other material labor disputes involving any Business Employee pending or, to the knowledge of the Borrower, threatened
in writing, nor have there been any such controversies, strikes, slowdowns or work stoppages in the past three years. There are no grievances
or unfair labor practice complaints pending against the Borrower or any of its Subsidiaries before the National Labor Relations Board
or any other Governmental Entity with respect to any Business Employee.
(ii) Except as would not reasonably be expected to have a Material Adverse Effect, the Borrower and its Subsidiaries are, and have
been for the past three years, in compliance i with all applicable Laws relating to labor, employment, fair employment practices, terms
and conditions of employment, immigration, and wages and hours, and there are no complaints, lawsuits, arbitrations, administrative proceedings,
or other proceedings pending or, to the knowledge of the Borrower, threatened in writing against the Borrower or any of its Subsidiaries
brought by or on behalf of any applicant for employment, any current or former employee, any person alleging to be a current or former
employee, any class of the foregoing, or any Governmental Entity, relating to any such Law, or alleging breach of any express or implied
contract of employment, wrongful termination of employment, or any other discriminatory, wrongful or tortious conduct in connection with
the employment relationship.
(iii) Except
as would not reasonably be expected to have a Material Adverse Effect, all of the independent contractors and service providers of the
Borrower and its Subsidiaries are and have been rightly classified as independent contractors and, to the knowledge of the Borrower,
(i) no contractor, freelancer or consultant has claimed to be an employee of the Borrower or its Subsidiaries within the last five years
prior to the date hereof and (ii) neither the Borrower nor any of its Subsidiaries employs any independent contractor, freelancer or
consultant who is in fact a disguised employee (Scheinselbstständiger) under the applicable Laws of the Borrower or the respective
Subsidiary’s jurisdiction.
(iv) Schedule 4(bb)(iv)(1) sets forth a complete and correct list of all officers and directors of the Borrower and any Subsidiary
of the Borrower by: name; title or position; status (part-time, full-time, exempt, non-exempt, etc.); whether paid on a salaried, hourly
or other basis; current base salary or wage rate; current target bonus; start date; service reference date (if different from the start
date); work location (city and state); vacation entitlement formula; amount of accrued but unused vacation; and an indication of whether
or not such employee is on leave of absence.
(cc) [Reserved]
(dd) Employee
Benefit Matters.
(i) Each material Benefit Plan is listed on Schedule 4(cc). Each Benefit Plan (A) has been operated and administered in all
material respects in accordance with its terms and applicable Law, (B) which is a “nonqualified deferred compensation plan”
(within the meaning of Section 409A of the Code) is and has at all relevant times been operated, administered and documented in
compliance in all material respects with Section 409A of the Code and all proposed and final IRS guidance thereunder, and (C) which
is intended to be “qualified” within the meaning of Section 401(a) of the Code has received a favorable determination
or opinion letter as to its qualification, and nothing has occurred, whether by action or failure to act, that would reasonably be expected
to cause the loss of such qualification.
(ii) There are no pending, or to the knowledge of the Borrower, threatened in writing claims by or on behalf of any Benefit Plan, by
any employee or beneficiary covered under any such Benefit Plan, or otherwise involving any such Benefit Plan (other than routine claims
for benefits).
(iii) With respect to each Benefit Plan, the Borrower has delivered to Lender true and complete copies, as applicable, of (A) the plan
document (including all amendments thereto) and any related trust agreement and other governing documents, (B) the most recent annual
report (Form 5500 Series) filed with the IRS, (C) the most recent financial statements and actuarial valuation, (D) the most recent summary
plan description and any summaries of material modification thereto, (E) the most recent favorable determination or opinion letter received
from the IRS and (F) any non-routine, material correspondence with any Governmental Entity during the past three years.
(iv) Neither
the Borrower, any of its Subsidiaries, nor, to the knowledge of the Borrower, any other “disqualified person” or “party
in interest” (as defined in Section 4975(e)(2) of the Code and Section 3(14) of ERISA, respectively) has engaged in any
transactions in connection with any Benefit Plan that would reasonably be expected to result in the imposition of a penalty pursuant
to Section 502 of ERISA, damages pursuant to Section 409 of ERISA or a tax pursuant to Section 4975 of the Code.
(v) Except
as set forth in Schedule 4(cc)(v), no current or former managing director, employee or any other individual engaged by the
Borrower or any of its Subsidiaries is entitled to (A) a bonus, retention payment, severance payment, performance orientated payment
or comparable payments regarding the consummation of the transactions contemplated by this Agreement and/or continued service or employment
with the Borrower or its Subsidiaries, (B) any payments under or in connection with any virtual share option, equity option, equity incentive
plan or other employee participation programs of the Borrower or any of its Subsidiaries or (C) any payment that could, individually
or in combination with any other such payment, constitute an “excess parachute payment,” as defined in Section 280G(b)(1)
of the Code.
(vi) Except as set forth in Schedule 4(cc)(vi) and except to the extent only implementing or reflecting mandatory legal obligations
or mandatory legal requirements
pursuant
to applicable Law, no pension plan, pension scheme, pension related arrangement or promises exist under which any current or former managing
director or employee of the Borrower or an Affiliate has any entitlements (jointly the “Pension Commitments”). With
regard to the Pension Commitments, as of the date hereof, all pension payments (including any mandatory adjustments) and contributions
have been made and all fees for reinsurances as well as insolvency coverage have been paid in full and sufficient book reserves have
been established for any unfunded pension liabilities in accordance with the latest actuarial reports. All Pension Commitments have been
made and, where applicable, changed, amended, replaced, closed or terminated, in compliance with all applicable requirements of all applicable
Laws.
(vii) Neither
the Borrower nor any ERISA Affiliate has sponsored, maintained, contributed to or been required to maintain or contribute to, or has
any actual or contingent liability under, any Benefit Plan that is subject to Section 302 or Title IV of ERISA or Section 412
or 430 of the Code or is otherwise a defined benefit pension plan within the meaning of ERISA or is a multiple employer plan (as described
in Section 413(c) of the Code) or a multiple employer welfare arrangement (as defined in Section 3(40) of ERISA).
(viii) No
Benefit Plan provides health, medical or other welfare benefits after retirement or other termination of employment (other than for continuation
coverage required under Section 4980(B)(f) of the Code), and no circumstances exist that could result in the Borrower or any of
its Affiliates becoming obligated to provide any such benefits.
(ee) Anti-Corruption.
(i) None
of the Borrower, any of its Subsidiaries, directors, officers, or employees, nor, to the knowledge of the Borrower, any agent, representative,
consultant or any other Person acting on behalf of the Borrower or any of its Subsidiaries (and only in their capacities as such) has,
within the last five years and in connection with the business of the Borrower or any of its Subsidiaries: (A) unlawfully offered,
paid, promised to pay, or authorized the payment of, directly or indirectly, anything of value, including money, loans, gifts, travel,
or entertainment, to any Government Official with the purpose of (1) influencing any act or decision of such Government Official in his
or her official capacity; (2) inducing such Government Official to perform or omit to perform any activity in violation of his or her
legal duties; (3) securing any improper advantage; or (4) inducing a Government Official to influence or affect any act or decision
of such Governmental Entity; (B) made any illegal contribution to any political party or candidate; (C) made, offered or promised to
pay any unlawful bribe, payoff, influence payment, kickback, unlawful rebate, or other similar unlawful payment of any nature, directly
or indirectly, in connection with the business of the Borrower, to any person, including any supplier or customer; (D) knowingly established
or maintained any unrecorded fund or asset or made any false entry on any book or record of the Borrower or any of its Subsidiaries for
any purpose; or (E) otherwise violated any Anti-Corruption Laws.
(ii) The Borrower represents and warrants that it will comply with all Anti-Corruption Laws and will not, directly or indirectly, make
any offer, payment, promise to pay, or authorize the payment, of money or anything else of value to any Person, including any Government
Official, in violation of any Anti-Corruption Law, or make any illegal or improper bribe, rebate, payoff, influence payment, kickback
or other unlawful or improper payment or benefit.
(iii) At
all times during the past five years, the Borrower has implemented and maintained policies and procedures reasonably designed to promote
and achieve compliance by the Borrower and its Subsidiaries and their respective directors, officers, employees, and agents with the
Anti-Corruption Laws. The Borrower will continue to maintain and enforce such policies and procedures.
(iv) The
Borrower, its Subsidiaries, and their respective Representatives have not been the subject of any actual, suspected, or threatened in
writing allegations, investigations, litigation, voluntary or directed disclosures to any Government Entity (including but not limited
to the U.S. Department of Justice, U.S. Securities Exchange Commission, or U.K. Securities Fraud Office), whistleblower reports, or other
issues concerning suspected violation of the Anti-Corruption Laws.
(ff) Sanctions and Trade Controls. The Borrower has, within the last five years: (i) complied with applicable Trade
Control Laws and Sanctions; (ii) maintained in place and implemented controls and systems reasonably designed to comply with applicable
Trade Control Laws and Sanctions; (iii) not engaged in a transaction or dealing, direct or indirect, with or involving a Sanctioned Country
or Sanctioned Person; and (iv) not been the subject of or otherwise involved in investigations or enforcement actions by any Governmental
Entity or other legal proceedings with respect to any actual or alleged violations of Trade Control Laws or Sanctions, and has not been
notified in writing of any such pending or threatened actions. Neither the Borrower nor any director, officer or, to the knowledge of
the Borrower, employee or agent of the Borrower is: (x) a Sanctioned Person; (y) subject to debarment or any list-based designations
under any Trade Control Law; or (z) engaged in transactions, dealings, or activities that might reasonably be expected to cause such
Person to become a Sanctioned Person.
Section 5.
Representations, Warranties and Covenants of Lender. Lender represents, and warrants
to the Borrower and covenants that:
(a) Authorization, Execution and Delivery of This Agreement. Lender has full power and authority to execute and deliver,
and perform its obligations under, and has duly authorized, executed and delivered, each Transaction Document.
(b) Non-Contravention. The consummation of the transactions contemplated by the Transaction Documents to be performed by
Lender, including the funding of the Loan by Lender pursuant to this Agreement, will not (i) contravene any Law binding on Lender or
any investment guideline or restriction applicable to Lender; or (ii) constitute a breach or violation or result in a default under the
organizational documents of Lender or any material loan agreement, mortgage, lease or other agreement or instrument to which Lender is
a party or by which it is bound.
(c) Acknowledgement
of Risks; Investment and Transaction Sophistication. Lender understands and accepts that the Loan involves risks. Lender has such
knowledge, skill and experience in business, financial and investment matters that Lender is capable of evaluating the merits and risks
of the transactions contemplated by the Transaction Documents. With the assistance of Lender’s own professional advisors, to the
extent that Lender has deemed appropriate, Lender has made its own legal, tax, accounting and financial evaluation of the merits and
risks of an investment in the Loan and the consequences of the transactions contemplated by this Agreement. Lender has considered the
suitability and repayment of the Loan as an investment in light of Lender’s own circumstances and financial condition, and Lender
is able to bear the risks associated therewith. Lender acknowledges that it may be required to hold the Loan and any Underlying Shares
for an indefinite period of time and that it will bear the related economic risks, including the risk of a complete loss of its investment.
(d) No
Registration. Investor is a “qualified institutional buyer” (within the meaning of Rule 144A under the Securities Act)
or an “accredited investor” (within the meaning of Rule 21 501 of Regulation D under the Securities Act) and is aware that
the issuance of the Underlying Shares upon conversion of the Loan in the manner contemplated by the Transaction Documents shall be made
in reliance on a private placement exemption from registration under the Securities Act. Upon conversion, Investor shall acquire the
Underlying Shares solely for Investor’s own beneficial account, for investment purposes, and not with a view to, or for resale
in connection with any distribution of the Underlying Shares in violation of the Securities Act. Investor understands that the offer
and issuance of the Underlying Shares upon conversion shall not be registered under the Securities Act or any state securities laws by
reason of specific exemptions under the provisions thereof that depend in part upon the investment intent of Investor and the accuracy
of the other representations made by Investor in this Agreement and that the Company is relying on the representations, warranties and
agreements contained herein for the purpose of determining whether the offer and issuance of the Underlying Shares upon conversion meet
the requirements for such exemptions.
(e) Restricted
Securities. Investor understands and acknowledges that the Underlying Shares, if any, are “restricted securities” within
the meaning of Rule 144(a)(3) under the Securities Act, and may not be Transferred unless pursuant to a registration statement that is
effective under the Securities Act or pursuant to an exemption from the registration requirements of the Securities Act and in compliance
with any restrictive legend imprinted thereon to the same effect.
Section 6.
Further Covenants of the Parties.
(a) Right
to Nominate Lender Directors.
(i) Generally.
For so long as (x) the Loan funded on the Closing Date remains outstanding or (y) following any conversion of the Loan, Lender and its
Permitted Transferees continue to have record and beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act) of at
least 10% of the outstanding Common Shares of the Borrower (in each case, the “Nomination Right Condition”), Lender
and its Permitted Transferees, if any, shall have the right to designate two persons for appointment to the Supervisory Board of Directors
(an “Lender Nominee”), at each
annual
general meeting of shareholders of the Borrower in which one or more members of the Supervisory Board of Directors are up for appointment
or re-appointment. If Lender and its Permitted Transferees, if any, have the right to so designate one or two Lender Nominees in a given
year, the Supervisory Board of Directors shall upon each such designation having been made nominate each Lender Nominee so designated
for appointment or re-appointment, as applicable, by the general meeting of shareholders of the Borrower to the Supervisory Board of
Directors in accordance with the Articles of Association and Dutch law. If, following appointment or re-appointment to the Supervisory
Board of Directors, a Lender Nominee resigns, is removed, is not re-appointed or is otherwise unable to serve for any reason and Lender
and its Permitted Transferees, if any, still have the right to designate a Lender Nominee, then Lender and its Permitted Transferees,
if any, shall be entitled to designate a replacement Lender Nominee, and the Supervisory Board of Directors shall upon such designation
nominate the Lender Nominee for appointment by the general meeting of shareholders to the Supervisory Board of Directors in accordance
with the Articles of Association and Dutch law. In the event that Lender and its Permitted Transferees, if any, cease to satisfy either
Nomination Right Condition, if requested by the Supervisory Board of Directors, Lender and its Permitted Transferees, if any, shall use
reasonable efforts to have such Lender Nominee resign as a member of the Supervisory Board of Directors.
(ii) Subject
to all applicable legal and Nasdaq listing requirements, in the event any Lender Nominee is appointed to the Supervisory Board of Directors,
the Borrower shall take all action reasonably necessary to ensure such Lender Nominee serves as a member of one committee of the Supervisory
Board of Directors (other than the Audit Committee), in accordance with the Borrower’s Articles of Association and other organizational
documents of the Borrower.
(iii) In the event any Lender Nominee is appointed to the Supervisory Board of Directors, such Lender Nominee shall be entitled to indemnification
in the same manner and to the same extent as the other members of the Supervisory Board of Directors, in accordance with the Borrower’s
organizational documents and on the basis of the form of director indemnification agreements filed in the SEC Documents.
(iv) At
all times when the Nomination Right Condition is satisfied without a Lender Nominee serving as a member of the Supervisory Board of Directors,
if requested by Lender, the Borrower shall (or it shall cause its management board or its Supervisory Board of Directors, as applicable,
to) convene an extraordinary general meeting of shareholders of the Borrower for the appointment of such then-current Lender Nominee
to the Supervisory Board of Directors. Notwithstanding anything to the contrary in this Section 6(a)(iv), if the Borrower’s
next general meeting of shareholders is scheduled to occur within 90 days after a request from Lender pursuant to this Section 6(a)(iv),
and the Borrower is otherwise permitted to conduct such appointment at such next general meeting, then such appointment will instead
be included in the agenda for, and conducted at, such next general meeting of the shareholders.
(b) Restrictions
on Transfer. Lender shall not Transfer any amount of the Loan to any Person (i) without the consent of the Borrower and (ii) unless
such Person executes and delivers
a
joinder to the Oxford Subordination Agreement to Oxford concurrently with, but immediately prior to, such Transfer, such joinder to be
in form and substance reasonably satisfactory to Oxford Finance LLC (or in the case of a refinancing of the Oxford Loan, the lenders
providing such refinancing). Notwithstanding the foregoing, without the consent of the Borrower (but subject to the requirement to execute
and deliver a joinder to the Oxford Subordination Agreement described in clause (b)(ii) above), Lender may Transfer the Loan, in whole,
but not in part (i) to any transferee that is (x) a wholly owned direct or indirect Subsidiary of the Lender; or (b) a parent that owns
100% of the Lender (but does not include, for the avoidance of doubt, any Subsidiary of any such parent other than the Lender and its
wholly owned direct or indirect Subsidiaries), (ii) following the date the Borrower commences a voluntary case under Title 11 of the
United States Bankruptcy Code or any other similar insolvency laws or (iii) upon the occurrence of a Default or Event of Default
(each as defined in the Terms and Conditions) (each transferee pursuant to clauses (i), (ii) and (iii), a “Permitted Transferee”).
Following any Transfer to a Permitted Transferee, such Permitted Transferee shall be deemed a “Lender” for purposes of this
Agreement and the terms and conditions contained herein shall apply to such Permitted Transferee. Any attempted Transfer in violation
of this Section 6(b) or applicable securities laws shall be void ab initio.
(c) Authorized
Shares. At all times when the Loan is outstanding, the Borrower shall use its best efforts to ensure that its authorized share capital
(“maatschappelijk kapitaal”) is sufficient for the conversion of the Loan, and upon issuance of the Underlying Shares
in accordance with the terms hereof, as applicable, such Underlying Shares will be duly and validly issued, fully paid and nonassessable
(meaning that the holder of a Common Share shall not by reason of merely being such a holder be subject to
assessment or calls by the Company or its creditors for further payment on such Common Share) and free of restrictions on transfer
other than the Borrower’s governing documents, applicable federal and state securities laws or Liens created by or imposed by Lender.
The Borrower covenants and agrees that it will not issue or grant Capital Shares such that the Borrower has an insufficient number of
unissued Common Shares comprised in the authorized share capital for the Maximum Number of Underlying Shares to be issued in the event
of conversion of the Loan at any time.
(d) Use
of Proceeds. The Borrower shall use the proceeds from the Loan to (i) fund working capital and general corporate purposes, (ii) pay
for the fees and expenses payable by the Borrower in connection with the transactions contemplated by this Agreement, and (iii) fund
at least $5.0 million U.S. Dollars for the joint venture with Lender (the “Joint Venture”) in accordance with that
certain Joint Venture Agreement, dated June 26, 2023.
(e) Additional
Documentation. Lender will, upon request, execute and deliver any additional documents that the Borrower may reasonably request to
complete the transactions contemplated by the Transaction Documents.
(f) Indebtedness.
Without Lender’s prior written consent, the Borrower shall not, and shall cause its Subsidiaries not to, (i) create, incur, assume
or be liable for any Indebtedness (other than the Oxford Loan) that is secured by any security interest or Lien in the Borrower’s
assets in favor of any Person, unless the Loan is secured on an equal and ratable basis with such Indebtedness or (ii) incur Indebtedness
under that certain Loan and Security Agreement, dated as of January 31, 2022 among the Borrower, certain Subsidiaries of the Borrower,
Oxford Finance
LLC
and the Lenders party thereto from time to time, as amended, supplemented, restated, renewed, replaced, refinanced or extended from time
to time (the “Oxford Loan”) in an aggregate principal amount outstanding exceeding $50,000,000 (or at any time prior
to an Insolvency Proceeding (as defined in the Oxford Subordination Agreement) of the Borrower or any of its material Subsidiaries, such
larger amount with the prior written consent of Lender and from and after such Insolvency Proceeding such consent shall not be required)
and all other Obligations (as defined in the Oxford Loan) in respect of the Oxford Loan. For the sake of clarity, the aggregate principal
amount of the Oxford Loan shall not include interest, Lenders’ Expenses, the Prepayment Fee, the Final Payment, the payment under
the Success Fee Agreement (as such terms are defined in the Oxford Loan) or other amounts due to the collateral agent and the lenders
in respect of the Oxford Loan.
(g) Rights
Upon Conversion. Following (a) the conversion of the Loan into Common Shares and (b) the acquisition by any Person, directly or indirectly,
of beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act) of a percentage of the outstanding shares of the Borrower
that is greater than the ownership percentage of the outstanding shares in the Borrower beneficially owned (within the meaning of Rule
13d-3 under the Exchange Act) by the Lender at such time, the Borrower and the Lender shall negotiate in good faith and enter into a
shareholders agreement or similar agreement with the Lender (a “Lender Shareholders Agreement”) containing customary
minority rights in favor of the Lender. The LSA Notice shall set forth the Borrower’s proposal for the terms of the Lender Shareholders
Agreement. If, at such time, no Take-Private Transaction has occurred, such terms shall be limited to customary negative consent rights
(limited to the following matters: amendments to charter documents, material acquisitions, material agreements, incurrence of indebtedness,
material changes to the nature of the business, related party transactions, and amendments to the Joint Venture documents, in each case,
subject to limitations and qualifications to be agreed; provided, however, by way of example and without limitation, that
the Company shall not be required to agree to any particular consent right if the Supervisory Board of Directors or the Company’s
Management Board of Directors determine that the provision of such consent right would violate their respective fiduciary duties under
applicable Law or violate any Nasdaq requirements applicable to the Company) and information rights in favor of the Lender. If, at such
time, a Take-Private Transaction has occurred, such rights may include, without limitation, customary minority consent rights (including
the rights described in the preceding sentence), preemptive rights, rights of first refusal, rights of co-sale and information rights
in favor of the Lender. Nothing in the Lender Shareholders Agreement or this Section 6(g) shall limit the Lender’s rights under
Section 6(a) or the Preemptive Rights Agreement or the ROFO Agreement. In the event that following delivery of the LSA Notice a Take-Private
Transaction occurs, the Lender may deliver another written notice (a “Subsequent LSA Notice”) to the Borrower of its
obligation to negotiate in good faith and enter into a shareholders agreement or similar agreement with the Lender (which may be an amendment
to the Lender Shareholders Agreement) (a “Subsequent Lender Shareholders Agreement”) setting forth the Lender’s
proposal for the terms of such Subsequent Lender Shareholders Agreement, which may include, among other things, customary minority consent
rights, preemptive rights, rights of first refusal, rights of co-sale and information rights in favor of the Lender. Upon receipt of
the LSA Notice or Subsequent LSA Notice, the Lender and the Borrower shall negotiate in good faith the terms of the Lender Shareholders
Agreement or Subsequent Lender Shareholders Agreement proposed by the Borrower in the LSA Notice as promptly as reasonably practicable,
provided, however,
that
the minority rights provided to the Borrower shall be no less favorable to the Lender than the minority rights provided to other shareholders
of the Borrower holding the same or a smaller percentage of the outstanding shares of capital stock of the Borrower as the Lender holds
as of the time of the negotiation.
Section 7.
Conditions to Obligations of the Borrower and Lender.
(a) Conditions to the Obligations of the Borrower. The obligation of the Borrower to execute and deliver the Transaction
Documents to which it is a party to Lender is subject to the satisfaction at or prior to the Closing of each of the following conditions
precedent: (i) the representations, warranties and covenants of Lender in Section 5 hereof are true and correct as of the
Closing in all respects with the same effect as though such representations and warranties had been made as of the Closing; (ii) the
Borrower shall have received the consent under the Oxford Loan; (iii) all covenants of Lender in Section 5 to be performed
at or before the Closing have been performed; and (iv) receipt of the Loan proceeds in accordance with Section 3(b)(ii).
(b) Conditions
to Lender’s Obligations. The obligation of Lender to fund its Loan Commitment Amount pursuant to this Agreement is subject
to the satisfaction at or prior to the Closing of each of the following conditions precedent: (i) the representations, warranties and
covenants of the Borrower in Section 4 and Section 6 hereof are true and correct in all material respects, and
the Borrower shall have performed and complied in all respects with such agreements and covenants required to be performed and complied
with prior to the Closing, (ii) Lender shall have received a copy of the resolutions adopted by the Supervisory Board of Directors and
the Borrower’s management board approving the Transaction Documents and the transactions contemplated hereby and thereby (including
the borrowing of the Loan), together with a certificate executed by one or more members of the management board on behalf of the Borrower
certifying (A) the Borrower has the authority to execute, deliver, and perform its obligations under each of the Transaction Documents,
(B) that set forth as a part of or attached as an exhibit to such certificate is a true, correct, and complete copy of the resolutions
then in full force and effect authorizing and ratifying the execution, delivery, and performance by the Borrower of the Transaction Documents,
(C) the name(s) of the Person(s) authorized to execute the Transaction Documents on behalf of the Borrower, together with a sample of
the true signature(s) of such Person(s), and (D) that the conditions to be satisfied on or prior to the Closing Date have been satisfied
by the Borrower, (iii) Lender shall have received a copy of a legal opinion of Davis Polk & Wardwell LLP in customary form regarding
the Loan reasonably satisfactory to Lender (the “Closing Legal Opinion”), (iv) no event shall have occurred which
would cause, or be reasonably likely to cause, any Material Adverse Effect to occur on or prior to the Closing Date, (v) the Borrower
and its Subsidiaries shall have obtained all authorizations from any applicable Governmental Entity and all consents of other Persons,
in each case that are necessary or advisable in connection with the transactions contemplated by the Transaction Documents, including
consent under the Oxford Loan, and each of the foregoing shall be in full force and effect and in form and substance reasonably satisfactory
to Lender, (vi) Lender shall have received a duly executed copy of the Borrower’s counterpart to the final definitive documents
to form the Joint Venture.
Section 8.
The Release Time. (a) As of the date
of this Agreement, the Borrower is not aware of, and has not provided to Lender, any material non-public information regarding the
Borrower
or its securities, other than any material non-public information relating to the transactions contemplated by this Agreement; and (b)
the Borrower agrees to publicly disclose at or before 8:30 a.m., New York City time, on the first Business Day after the date of this
Agreement (such time and date, the “Release Time”), the material terms of this Agreement and the transactions contemplated
hereby in a press release or other public announcement. The Borrower acknowledges and agrees that, as of the Release Time, none of the
information provided by or on behalf of the Borrower to Lender in connection with the transactions contemplated by this Agreement will
constitute material non-public information.
Section 9.
Tax Matters. The Borrower shall be responsible of all applicable Taxes, including
withholding tax, that will arise from this Agreement.
Section 10.
Miscellaneous.
(a) Survival.
All of the agreements, covenants, representations and warranties made by each party hereto in this Agreement shall survive the Closing.
(b) Entire Agreement; Waiver; Amendment. This Agreement and the other Transaction Documents (including any schedules and
exhibits hereto and thereto) represent the entire understanding and agreement between the parties hereto with respect to the subject
matter hereof. Nothing expressed or implied in this Agreement is intended or shall be construed so as to grant or confer on any person,
firm or corporation other than the parties hereto, any rights or privileges hereunder. This Agreement can be amended, supplemented, changed,
discharged or terminated and any provision hereof can be waived, only by written instrument making specific reference to this Agreement
signed by the parties hereto. No action taken pursuant to this Agreement shall be deemed to constitute a waiver by the party taking such
action of compliance with any agreement contained herein. The waiver by any party hereto of a breach of any provision of this Agreement
shall not operate or be construed as a further or continuing waiver of such breach or as a waiver of any other or subsequent breach.
No failure on the part of any party to exercise, and no delay in exercising, any right, power or remedy hereunder shall operate as a
waiver thereof, nor shall any single or partial exercise of such right, power or remedy by such party preclude any other or further exercise
thereof or the exercise of any other right, power or remedy.
(c) Assignability.
Subject to Section 6(b), neither this Agreement nor any right, remedy, obligation or liability arising hereunder or by reason
hereof will be assignable by either the Borrower, on the one hand, or Lender, on the other hand, without the prior written consent of
the other party.
(d) Further
Instruments and Acts. Each of the parties to this Agreement agrees to execute and deliver such further instruments and do such further
acts as may be reasonably necessary or proper to more effectively carry out the purposes of this Agreement and the other Transaction
Documents.
(e) Waiver
of Jury Trial. EACH OF THE BORROWER AND LENDER IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY WITH RESPECT
TO
ANY LEGAL PROCEEDING ARISING OUT OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT.
(f) Governing
Law. This Agreement will be governed by and construed in accordance with the internal laws of the State of New York.
(g) Arbitration. Each party agrees that any dispute, difference, claim, question or controversy arising out of or in connection
with the Transaction Documents, which is not amicably settled between the parties hereto within a period of one month from the date of
the start of negotiations between the parties, shall be finally resolved pursuant to arbitration pursuant to the terms set forth in this
Section 10(g). New York, NY will be the place of arbitration. Arbitration shall be governed by Judicial Arbitration &
Mediation Services (“JAMS”) and its JAMS Comprehensive Rules and Procedures (“JAMS Rules”) in effect
at the time the arbitration is commenced. A panel of three neutral arbitrators will be selected in accordance with the JAMS Rules to
conduct the arbitration. The arbitration shall be conducted in English. The arbitral award shall be final and enforced in any court of
competent jurisdiction by either party. To the extent permissible by Law, the parties hereby waive any right to appeal the decision of
the arbitration. The arbitral tribunal may award legal costs and expenses as it deems fit. The parties hereby acknowledge and agree that
arbitrators may issue procedural orders and decide on interim measures/injunctions in the course of the arbitration. The parties hereunder
agree that any one of them may request in aid of arbitration from any court of competent jurisdiction, injunctive relief or other conservatory
measures. The parties hereto hereby agree that the fact of any arbitration hereunder, the content of any such proceedings and the outcome
thereof shall be treated as confidential and shall be held confidential by each party and their respective Representatives in accordance
with Section 10(n) of this Agreement.
(h) Counterparts.
This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including .pdf or any electronic
signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
(i) Notices
Section 11.. All notices
and other communications under this Agreement shall be in writing and shall be deemed given (a) when delivered personally by hand (with
written confirmation of receipt), (b) when sent by e-mail (with written confirmation of transmission) or (c) one Business Day following
the day sent by overnight courier (with written confirmation of receipt), in each case at the following addresses and facsimile numbers
(or to such other address or facsimile number as a Party may have specified by notice given to the other Party pursuant to this provision):
If
to Borrower:
Centogene
N.V.
Am
Strande 7
18055
Rostock
Germany
Attn:
[***]
Email:
[***]
with
a copy to (which shall not constitute notice):
Davis
Polk & Wardwell London LLP
5
Aldermanbury Square
London
EC2V 7HR
Attn: Leo Borchardt
Email: leo.borchardt@davispolk.com
And
Davis
Polk & Wardwell LLP
450 Lexington
Avenue
New York,
NY 10017
United
States
Attn:
David Hahn
Email: david.hahn@davispolk.com
And
NautaDutilh
N.V.
Beethovenstraat
400
1082
PR Amsterdam
The
Netherlands
Attn: Paul van der Bijl
Email: Paul.vanderBijl@nautadutilh.com
If
to Lender:
Alra’idah
Digital City, Building MU04, Al Nakhil District,
P.O.
Box 6847, Riyadh 11452,
The
Kingdom of Saudi Arabia
Attn:
[***]
Email: [***]
with
a copy to (which shall not constitute notice):
Latham
& Watkins LLP
Al-Tatweer
Towers, 7th Floor, Tower 1
King
Fahad Highway, PO Box 17411
Riyadh
11484, Saudi Arabia
Attn:
Ahmed el-Gaili, David Zaheer, and Gregory P. Rodgers
Email: Ahmed.el-Gaili@lw.com
david.zaheer@lw.com
Greg.Rodgers@lw.com
(j) Binding
Effect. The provisions of this Agreement will be binding upon and accrue to the benefit of the parties hereto and their respective
heirs, legal representatives, successors and permitted assigns.
(k) Severability.
If any term or provision of this Agreement is invalid, illegal or unenforceable in any jurisdiction, such invalidity, illegality or unenforceability
will not affect any other term or provision of this Agreement or invalidate or render unenforceable such term or provision in any other
jurisdiction.
(l) No
Third Party Beneficiaries. This Agreement is for the sole benefit of the parties hereto and their successors and permitted assigns
and nothing expressed or referred to in this Agreement will be construed to give any Person, other than the parties to this Agreement
and such permitted assigns, any legal or equitable right, remedy or claim under or with respect to this Agreement or any provision of
this Agreement, whether as third party beneficiary or otherwise.
(m) Interpretation.
Any reference to a contract, instrument or other document as of a given date means the contract, instrument or other document as amended,
supplemented and modified from time to time through such date. The headings contained in this Agreement are for convenience of reference
only and will not affect the meaning or interpretation of this Agreement. All preamble, recital, article, section, exhibit and schedule
references are to the preambles, recitals, articles, sections, exhibits and schedules of this Agreement unless otherwise specified. All
references in this Agreement to “dollars” or “$” are to U.S. dollars. All payments to be made in cash under this
Agreement or under any other Transaction Document are to be paid in U.S. dollars. All references in this Agreement to any period of days
will mean the relevant number of calendar days, unless otherwise specified. When calculating the period of time before which, within
which or following which, any act is to be done or step taken pursuant to this Agreement, the date that is the reference date in calculating
such period will be excluded, unless otherwise specified. If the last day of any period is a non-Business Day, the period in question
will end on the next succeeding Business Day, unless otherwise specified. Words in the singular will be held to include the plural and
vice versa. Words of one gender will be held to include the other genders and neutral as the context requires. The terms “hereof,”
“herein,” “hereunder,” “hereto” and “herewith” and words of similar import will, unless
otherwise stated, be construed to refer to this Agreement and not to any particular provision of this Agreement. The word “including”
and words of similar import when used in this Agreement will mean “including, without limitation,” unless otherwise specified.
The word “or” will not be exclusive. The parties acknowledge and agree that each has negotiated and reviewed the terms of
this Agreement, assisted by such legal and tax counsel as they desired, and has contributed to its revisions. The parties further agree
that the rule of construction that any ambiguities are resolved against the drafting party will be subordinated to the principle that
the terms and provisions of this Agreement will be construed fairly as to all parties and not in favor of or against any party.
(n)
Confidentiality Neither party hereto nor any of its Representatives may
make any press release or other public disclosure regarding the existence of this Agreement,
its contents, or the transactions contemplated by this Agreement without the written consent
of the other party, in any case, as to the form, content, and timing and manner of distribution
or publication of such press release or other public disclosure (which consent may not be
unreasonably withheld,
conditioned,
or delayed). Each party shall hold confidential the terms and provisions of this Agreement and the terms of the transactions contemplated
by this Agreement. Notwithstanding the foregoing, nothing in this Section 10(n) will prevent either party or its Representatives
from making any press release or other disclosure (a) required by Law or the rules of any stock exchange, in which case the party required
to make such press release or other disclosure shall use commercially reasonable efforts to allow the other party reasonable time to
review and comment on such release or disclosure in advance of its issuance or (b) to the accountants, Representatives, stockholders,
members and partners of such party and its Affiliates as necessary in connection with the ordinary conduct of their businesses (so long
as such Persons agree to keep the terms of this Agreement confidential).
(o) Subordination.
This Agreement, and the rights and obligations evidenced hereby, are subordinate in the manner and to the extent set forth in the Oxford
Subordination Agreement.
[The Remainder
of This Page Intentionally Left Blank; Signature Pages Follow]
IN
WITNESS WHEREOF, the parties to this Agreement have caused this Agreement to be duly executed as of the date first written above.
|
Lender: |
|
|
|
PHARMACEUTICAL INVESTMENT COMPANY |
|
|
|
By: |
/s/ Ibrahim Abdulrahman I Aljuffali |
|
|
Name: Dr. Ibrahim Abdulrahman I Aljuffali |
|
|
Title: Chairman |
[Signature Page to Loan Agreement]
IN
WITNESS WHEREOF, the parties to this Agreement have caused this Agreement to be duly executed as of the date first written above.
|
Borrower: |
|
|
|
CENTOGENE N.V. |
|
|
|
By: |
/s/ Kim Stratton |
|
|
Name: Kim Stratton |
|
|
Title: Chief Executive Officer |
|
|
|
|
|
|
|
By: |
/s/ Miguel Coego |
|
|
Name: Miguel Coego |
|
|
Title: Chief Financial Officer, Legal, & IT |
[Signature Page to Loan Agreement]
Schedule
A
Loan Commitment
Amount
Lender: |
Loan
Commitment Amount: |
Pharmaceutical
Investment Company |
$30,000,000 |
Total |
$30,000,000 |
EXHIBIT A
TERMS AND
CONDITIONS OF LOAN
Exhibit A
to Loan Agreement
dated as of
October 26, 2023
by and among
CENTOGENE N.V.,
as Borrower,
and
PHARMACEUTICAL
INVESTMENT COMPANY,
as Lender,
EXHIBIT A TO LOAN AGREEMENT
TABLE OF CONTENTS
Page
Article
1. Definitions; Rules of Construction |
1 |
Section
1.01. Definitions. |
1 |
Section
1.02. Other Definitions. |
7 |
Section
1.03. Rules of Construction. |
8 |
Article
2. The Loan |
9 |
Section
2.01. Method of Payment. |
9 |
Section
2.02. Accrual of Interest; Defaulted Amounts; When Payment Date is Not a Business Day. |
9 |
Section
2.03. Register. |
10 |
Article
3. Covenants |
10 |
Section
3.01. Payment Of The Loan. |
10 |
Section
3.02. Additional Amounts. |
10 |
Section
3.03. Stay, Extension and Usury Laws. |
12 |
Section
3.04. Corporate Existence. |
13 |
Section
3.05. Further Instruments and Acts. |
13 |
Section
3.06. Additional Interest. |
13 |
Article
4. Conversion Upon A Fundamental Change |
14 |
Section
4.01. Right of the Lender to Convert the Loan Upon a Fundamental Change. |
14 |
Article
5. Conversion |
15 |
Section
5.01. Right to Convert. |
15 |
Section
5.02. Conversion Procedures. |
16 |
Section
5.03. Settlement Upon Conversion. |
17 |
Section
5.04. Reserve and Status of Common Shares Issued Upon Conversion. |
17 |
Section
5.05. Adjustments to the Conversion Price. |
18 |
Section
5.06. Voluntary Adjustments. |
27 |
Section
5.07. Effect of Common Shares Change Event. |
27 |
Article
6. Successors |
29 |
Section
6.01. When the Borrower May Merge, Etc. |
29 |
Section
6.02. Successor Entity Substituted. |
29 |
Article
7. Defaults and Remedies |
30 |
Section
7.01. Events of Default. |
30 |
Section
7.02. Acceleration. |
32 |
Article
8. Miscellaneous |
32 |
Section
8.01. Notices. |
32 |
Section
8.02. No Personal Liability of Directors, Officers, Employees and Shareholders. |
33 |
Section
8.03. Governing Law; Waiver of Jury Trial. |
33 |
Section
8.04. Arbitration. |
34 |
Section
8.05. No Adverse Interpretation of Other Agreements. |
34 |
Section
8.06. Successors. |
34 |
Section
8.07. Calculations. |
34 |
Section
8.08. Severability. |
35 |
Section
8.09. Table of Contents, Headings, Etc. |
35 |
Section
8.10. Service of Process. |
35 |
Exhibits
Exhibit A: Form of Conversion Notice |
A-1 |
Exhibit B: Form of Assignment |
B-1 |
WHEREAS,
pursuant to the Loan Agreement to which these Terms and Conditions are attached, the Lender has agreed to make a convertible term loan
in dollars in an aggregate principal amount of $30,000,000 to Centogene N.V., a public company with limited liability (naamloze vennootschap)
incorporated under the laws of the Netherlands (the “Borrower”); and
WHEREAS,
these Terms and Conditions establish the rights and obligations of the Borrower under, and the terms and conditions of, the Loan and
the Transaction Documents. Capitalized terms used herein without definition have the respective meanings ascribed to them in the Loan
Agreement.
Article
1. Definitions;
Rules of Construction
Section
1.01. Definitions.
“Additional
Interest” has the meaning ascribed to it in the Registration Rights Agreement.
“Affiliate”
has the meaning set forth in Rule 144 as in effect on the Closing Date.
“Bankruptcy
Law” means Title 11, United States Code, or any similar U.S. federal or state or non-U.S. law for the relief of debtors.
“Board
of Managing Directors” means the board of managing director (bestuur) of the Borrower.
“Borrower”
means the Person named as such in the first paragraph of these Terms and Conditions and, subject to Article 6, its successors
and assigns.
“Business
Day” means any day other than a Saturday, a Sunday or any day on which banking institutions in New York, New York, United States,
Riyadh, Saudi Arabia or Frankfurt am Main, Germany are authorized or required by Law or executive order to close or be closed.
“Capital
Shares” of any Person means any and all shares of, interests in, rights to purchase, warrants or options for, participations
in, or other equivalents of, in each case however designated, the equity of such Person, but excluding any debt securities convertible
into such equity.
“Close
of Business” means 5:00 p.m., New York City time.
“Closing
Date” has the meaning ascribed to it in the Loan Agreement.
“Common
Shares” means the common shares, nominal value €0.12 per share, of the Borrower, subject to Section 5.07.
“Conversion
Date” means, with respect to the Loan, the first Business Day on which the requirements set forth in Section 5.02(A)
to convert the Loan are satisfied or, in the case of any conversion pursuant to Section 5.01(D), the Maturity Date. The Conversion
Date with respect to
any conversion
at the Borrower’s option pursuant to Section 5.01(E) is the date on which the Borrower provides the notice contemplated
by Section 5.01(E). For purposes of Section 5.05, references to “Conversion Date” shall include any Fundamental
Change Conversion Date.
“Conversion
Fee Shares” has the meaning assigned in Section 3.01.
“Conversion
Price” initially means $2.20 per Common Share; provided, however, that the Conversion Price is subject to adjustment
pursuant to Article 5; provided, further, that whenever these Terms and Conditions refer to the Conversion Price
as of a particular date without setting forth a particular time on such date, such reference will be deemed to be to the Conversion Price
immediately after the Close of Business on such date and further, provided that, the Conversion Price per Common Share shall never
be less than the nominal value of one Common Share.
“Conversion
Share” means any Common Share issued or issuable upon conversion of the Loan.
“Default”
means any event that is (or, after notice, passage of time or both, would be) an Event of Default.
“Effective
Price” has the following meaning with respect to the issuance or sale of any Common Shares or any Equity-Linked Securities:
(A) in
the case of the issuance or sale of Common Shares, the value of the consideration received by the Borrower for such shares, expressed
as an amount per Common Share; and
(B) in
the case of the issuance or sale of any Equity-Linked Securities, an amount equal to a fraction whose:
(i) numerator
is equal to sum, without duplication, of (x) the value of the aggregate consideration received by the Borrower for the issuance or sale
of such Equity-Linked Securities; and (y) the value of the minimum aggregate additional consideration, if any, payable to purchase or
otherwise acquire Common Shares pursuant to such Equity-Linked Securities; and
(ii) denominator
is equal to the maximum number of Common Shares underlying such Equity-Linked Securities;
provided,
however, that:
(x) for
purposes of clause (B) above, if such minimum aggregate consideration, or such maximum number of Common Shares, is not determinable
at the time such Equity-Linked Securities are issued or sold, then (I) the initial consideration payable under such Equity-Linked Securities,
or the initial number of Common Shares underlying such Equity-Linked Securities, as applicable, will be used; and (II) at each
time
thereafter when such amount of consideration or number of shares becomes determinable or is otherwise adjusted (including pursuant to
“anti-dilution” or similar provisions), there will be deemed to occur, for purposes of Section 5.05(A)(vi), as applicable,
and without affecting any prior adjustments theretofore made to the Conversion Price, an issuance of additional Equity-Linked Securities;
(y) for
purposes of clause (B) above, the surrender, extinguishment, maturity or other expiration of any such Equity-Linked Securities
will be deemed not to constitute consideration payable to purchase or otherwise acquire Common Shares pursuant to such Equity-Linked
Securities; and
(z) the
“value” of any such consideration will be the fair value thereof, as of the date such shares or Equity-Linked Securities,
as applicable, are issued or sold, determined in good faith by the Board of Managing Directors (or, in the case of cash denominated in
U.S. dollars, the face amount thereof).
“Equity-Linked
Securities” means any rights, obligations, options or warrants to purchase or otherwise acquire (whether immediately, during
specified times, upon the satisfaction of any conditions or otherwise) any Common Shares.
“Ex-Dividend
Date” means, with respect to an issuance, dividend or distribution on the Common Shares, the first date on which the Common
Shares trade on the applicable exchange or in the applicable market, regular way, without the right to receive such issuance, dividend
or distribution (including pursuant to due bills or similar arrangements required by the Relevant Stock Exchange). For the avoidance
of doubt, any alternative trading convention on the applicable exchange or market in respect of the Common Shares under a separate ticker
symbol or CUSIP number (or similar securities identifier) will not be considered “regular way” for this purpose.
“Exchange
Act” means the U.S. Securities Exchange Act of 1934, as amended.
“Exempt
Issuance” means (A) the Borrower’s issuance of any securities as full or partial consideration in connection with a strategic
merger, acquisition, consolidation or purchase of all or substantially all of the securities or assets of a corporation or other entity;
(B) the Borrower’s issuance or grant of Common Shares or options to purchase Common Shares to employees, directors or consultants
of the Borrower or any of its Subsidiaries for compensatory purposes, pursuant to plans that have been approved by a majority of the
independent members of the Board of Managing Directors or that exist as of the Closing Date; (C) the Borrower’s issuance of securities
upon the exercise, exchange or conversion of any securities that are exercisable or exchangeable for, or convertible into, Common Shares
and are outstanding as of the Closing Date, provided that such exercise, exchange or conversion is effected pursuant to the terms
of such securities as in effect on the Closing Date; (D) the Borrower’s issuance of securities pursuant to any equipment loan or
leasing arrangement, real property leasing arrangement or debt financing from a bank or similar financial institution approved by a majority
of the disinterested members of the Board of Managing Directors; (E) the Borrower’s issuance of any Common Shares upon conversion
of the Loan; (F) the Borrower’s issuance of rights issued
pursuant to a shareholder
rights plan; provided that the issuance of any securities upon exercise of any such rights will be deemed to be an issuance for
purposes of Section 5.05(A)(vi); and (G) Common Shares or Equity-Linked Securities issued by reason of a dividend, share split,
split-up or other distribution on Common Shares that is covered by Section 5.05(A)(i) or Section 5.05(A)(v). For purposes
of this definition, “consultant” means a consultant that may participate in an “employee benefit plan” in accordance
with the definition of such term in Rule 405 under the Securities Act.
“Fundamental
Change” means any of the following events:
(A) the
acquisition by any party (or parties acting in concert) of Common Shares representing more than fifty percent (50%) of the voting power
of all of the Borrower’s Common Shares;
(B) the
consummation of (i) any sale, lease or other transfer, in one transaction or a series of transactions, of all or substantially all of
the assets of the Borrower and its Subsidiaries, taken as a whole, to any Person; or (ii) any transaction or series of related transactions
(whether by means of merger, demerger, consolidation, share exchange, business combination, reclassification, recapitalization, acquisition,
liquidation or otherwise), the result of which is the Borrower’s shareholders prior to such transaction or series of transactions
cease to own more than fifty percent (50%) of all classes of common equity of the Borrower or its successor following any such transaction
or series of transactions; or
(C) the
Borrower’s shareholders approve any plan or proposal for the liquidation or dissolution of the Borrower;
provided,
however, that a transaction or event described in clause (A) or (B) above will not be deemed to constitute a Fundamental
Change if (i) DPE Deutsche Private Equity GmbH, (ii) Careventures Fund II S.C.Sp and (iii) TVM Life Science Innovation I, L.P. or their
respective Affiliates (including Affiliates jointly owned thereof), each continue, immediately after such transaction or event described
in clause (A) or (B) to be the direct or indirect “beneficial owner” (as defined below) of substantially the
same number of Common Shares of the Borrower (or replacement equity interests in the surviving entity, acquirer, successor, or transferee,
as applicable (or the parent entity thereof)) as each “beneficially owned” as of the Closing Date.
For
the purposes of this definition, whether a Person is a “beneficial owner,” and whether shares are “beneficially
owned,” will be determined in accordance with Rule 13d-3 under the Exchange Act.
“Fundamental
Change Conversion Date” means the date fixed for the conversion of the Loan pursuant to the occurrence of a Fundamental Change.
“Interest
Payment Date” means, with respect to the Loan, (i) the date that is ninety (90) days from the Closing Date and (ii) the date
that is one-hundred-eighty (180) days from the Closing Date. For the avoidance of doubt, the Maturity Date is an Interest Payment Date.
“Internal
Revenue Code” means the United States Internal Revenue Code of 1986, as
amended.
“JAMS”
has the meaning specified in Section 8.04.
“JAMS
Rules” has the meaning specified in Section 8.04.
“Joint
Venture Agreement” means that certain joint venture agreement, dated June 26, 2023, between the Borrower and the Lender.
“Last
Reported Sale Price” of the Common Shares for any Trading Day means the closing sale price per Common Share (or, if no closing
sale price is reported, the average of the last bid price and the last ask price per Common Share or, if more than one in either case,
the average of the average last bid prices and the average last ask prices per Common Share) on such Trading Day as reported in composite
transactions for the principal U.S. national or regional securities exchange on which the Common Shares are then listed. If the Common
Shares are not listed on a U.S. national or regional securities exchange on such Trading Day, then the Last Reported Sale Price will
be the last quoted bid price per Common Share on such Trading Day in the over-the-counter market as reported by OTC Markets Group Inc.
or a similar organization. If the Common Shares are not so quoted on such Trading Day, then the Last Reported Sale Price will be the
average of the mid-point of the last bid price and the last ask price per Common Share on such Trading Day from each of at least three
(3) nationally recognized independent investment banking firms selected by the Borrower.
“Lender”
means that certain lender named in the Loan Agreement and its Permitted Transferees. For purposes of these Terms and Conditions, to the
extent all or any portion of the Loan made on the Closing Date is assigned by the Lender to a Permitted Transferee (or Permitted Transferees),
the use of the term “Lender” herein shall refer to such Permitted Transferee (or Permitted Transferees) and shall mean either
the singular or the plural as the context requires. The Lender under the Loan Agreement as of the Closing Date is Pharmaceutical Investment
Company.
“Loan”
means the convertible loan made by the Lender to the Borrower pursuant to the Loan Agreement and having the terms set forth in these
Terms and Conditions. To the extent all or any portion of the Loan made on the Closing Date is assigned by the Lender to a Permitted
Transferee (or Permitted Transferees), the use of the term “Loan” herein shall refer the all or any portion of the Loan held
by any Permitted Transferee (or Permitted Transferees).
“Loan
Agreement” means that certain Loan Agreement, dated October 26, 2023 between the Borrower, as borrower thereunder and the Lender,
as the same may be amended, supplemented, restated or otherwise modified from time to time. These Terms and Conditions form a part of
such Loan Agreement and are incorporated therein in all respects.
“Market
Disruption Event” means, with respect to any date, the occurrence or existence, during the one-half hour period ending at the
scheduled close of trading on such date on the Relevant Stock Exchange or other market on which the Common Shares are listed for trading
or trade, of any material suspension or limitation imposed on trading (by reason of
movements in price
exceeding limits permitted by the Relevant Stock Exchange or otherwise) in the Common Shares or in any options contracts or futures contracts
relating to the Common Shares.
“Maturity
Date” means the date that is one-hundred-eighty (180) days from the Closing Date.
“Officer”
means the Chairman of the Board of Managing Directors, the Chief Executive Officer, the President, the Chief Medical Officer, the Chief
Financial Officer, the Corporate Secretary or any Vice-President of the Borrower.
“Open
of Business” means 9:00 a.m., New York City time.
“Permitted
Transferee” has the meaning specified in the Loan Agreement.
“Person”
or “person” means any individual, corporation, partnership, limited liability company, joint venture, association,
joint-stock company, trust, unincorporated organization or government or other agency or political subdivision thereof. Any division
or series of a limited liability company, limited partnership or trust will constitute a separate “person” under these Terms
and Conditions.
“Preemptive
Rights Agreement” means that certain preemptive rights agreement, dated October 26, 2023, between the Borrower and the Lender.
“PIK
Interest Payment” has the meaning specified in Section 2.02(A)(i).
“Principal
Amount” means the principal amount of the Loan issued on the Closing Date, as such amount may be increased pursuant to the
payment-in-kind of any Stated Interest as provided in Section 2.02(A)(i).
“Relevant
Stock Exchange” means the principal securities exchange on which the Common Shares are listed; provided, however,
that if the Common Shares are listed on a U.S. national securities exchange, then the Relevant Stock Exchange will be such U.S. national
securities exchange. For the avoidance of doubt, the Relevant Stock Exchange as of the Closing Date is The Nasdaq Stock Market LLC.
“Registration
Rights Agreement” means that certain Registration Rights Agreement, dated as of October 26, 2023 between the Borrower and the
Lender, as the same may be amended or supplemented from time to time.
“Scheduled
Trading Day” means any day that is scheduled to be a Trading Day on the Relevant Stock Exchange or, if the Common Shares are
not then listed on a securities exchange, on the principal other market on which the Common Shares are then traded. If the Common Shares
are not so listed or traded, then “Scheduled Trading Day” means a Business Day.
“Securities
Act” means the U.S. Securities Act of 1933, as amended.
“Significant
Subsidiary” means, with respect to any Person, any Subsidiary of such Person that constitutes, or any group of Subsidiaries
of such Person that, in the aggregate, would constitute, a “significant subsidiary” (as defined in Rule 1-02(w) of Regulation
S-X under the Exchange Act) of such Person.
“Subsidiary”
means, with respect to any Person, (A) any corporation, association or other business entity (other than a partnership or limited liability
company) of which more than fifty percent (50%) of the total voting power of the Capital Shares entitled (without regard to the occurrence
of any contingency, but after giving effect to any voting agreement or shareholders’ agreement that effectively transfers voting
power) to vote in the election of directors, managers or trustees, as applicable, of such corporation, association or other business
entity is owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of such Person; and (B)
any partnership or limited liability company where (i) more than fifty percent (50%) of the capital accounts, distribution rights, equity
and voting interests, or of the general and limited partnership interests, as applicable, of such partnership or limited liability company
are owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of such Person, whether in the
form of membership, general, special or limited partnership or limited liability company interests or otherwise; and (ii) such Person
or any one or more of the other Subsidiaries of such Person is a controlling general partner of, or otherwise controls, such partnership
or limited liability company.
“Tax”
means any tax, duty, levy, impost, assessment or other governmental charge (including penalties and interest and other similar liabilities
related thereto).
“Tender
Offer” means a tender offer for the Common Shares of the Borrower by any Person that would result in a Fundamental Change.
“Terms
and Conditions” means these Terms and Conditions.
“Trading
Day” means any day on which (A) trading in the Common Shares generally occurs on the principal U.S. national or regional securities
exchange on which the Common Shares are then listed or, if the Common Shares are not then listed on a securities exchange, on the principal
other market on which the Common Shares are then traded; and (B) there is no Market Disruption Event. If the Common Shares are not so
listed or traded, then “Trading Day” means a Business Day.
“Wholly
Owned Subsidiary” of a Person means any Subsidiary of such Person all of the outstanding Capital Shares or other ownership
interests of which (other than directors’ qualifying shares) are owned by such Person or one or more Wholly Owned Subsidiaries
of such Person.
Section
1.02. Other Definitions.
Term |
Defined
in Section |
“Additional Amounts” |
3.02(A) |
“Business Combination Event” |
6.01 |
“Common Shares Change Event” |
5.07(A) |
“Conversion Consideration” |
5.03(A) |
“Default Interest” |
2.02(B) |
“Defaulted Amount” |
2.02(B) |
“Degressive Issuance” |
5.05(A)(vi) |
“Event of Default” |
7.01(A) |
“Expiration Date” |
5.05(A)(v) |
“Expiration Time” |
5.05(A)(v) |
“FATCA” |
3.02(A)(iv) |
“Fundamental Change Notice” |
4.01(E) |
“Reference Property” |
5.07(A) |
“Reference Property Unit” |
5.07(A) |
“Register” |
2.03 |
“Relevant Taxing Jurisdiction” |
3.02(A) |
“Specified Courts” |
8.04 |
“Spin-Off” |
5.05(A)(iii)(2) |
“Spin-Off Valuation Period” |
5.05(A)(iii)(2) |
“Stated Interest” |
2.02(A) |
“Successor Entity” |
6.01(A) |
“Successor Person” |
5.07(A) |
“Tender/Exchange Offer Valuation Period” |
5.05(A)(v) |
“Transfer Taxes” |
3.02(B) |
“Weighted Average Issuance Price” |
5.05(A)(vi) |
Section
1.03. Rules of Construction.
For
purposes of these Terms and Conditions:
(A)
“or” is not exclusive;
(B)
“including” means “including without limitation”;
(C)
“will” expresses a command;
(D)
the “average” of a set of numerical values refers to the arithmetic average of such numerical values;
(E) a merger involving, or a transfer of assets by, a limited liability company, limited partnership or trust will be deemed to include
any division of or by, or an allocation of assets to a series of, such limited liability company, limited partnership or trust, or any
unwinding of any such division or allocation;
(F)
words in the singular include the plural and in the plural include the singular, unless the context requires otherwise;
(G) “herein,”
“hereof” and other words of similar import refer to these Terms and Conditions as a whole and not to any particular Article,
Section or other subdivision of these Terms and
Conditions,
unless the context requires otherwise;
(H)
references to currency mean the lawful currency of the United States of America, unless the context requires otherwise;
(I)
the exhibits, schedules and other attachments to these Terms and Conditions are deemed to form part of these Terms and Conditions;
and
(J) the
term “interest,” when used with respect to the Loan, includes any Default Interest or Additional Interest, unless
the context requires otherwise.
Article
2. The
Loan
Section
2.01. Method of Payment.
Subject
to Section 5.01(D), the Borrower will pay the Principal Amount of, any cash Conversion Consideration for, the Loan no later than
the time the same is due as provided in these Terms and Conditions as follows: (i) if the Lender entitled to such payment has delivered
to the Borrower, no later than the time set forth in the immediately following sentence, a written request that the Borrower make such
payment by wire transfer to an account of such Lender, by wire transfer of immediately available funds to such account; and (ii) in all
other cases, by check mailed to the address of the Lender entitled to such payment. To be timely, such written request must be so delivered
no later than the Close of Business on the following date: (x) with respect to any cash Conversion Consideration, the relevant Conversion
Date or Fundamental Change Conversion Date; and (y) with respect to any other payment, the date that is fifteen (15) calendar days immediately
before the date such payment is due.
Section
2.02. Accrual of Interest; Defaulted Amounts;
When Payment Date is Not a Business Day.
(A) Accrual of Interest.
(i) The
Loan will accrue interest daily on the Principal Amount of the Loan at a rate per annum equal to 12.8% (the “Stated Interest”),
plus any Additional Interest that may accrue pursuant to the Registration Rights Agreement as of each such date, from and including,
the Closing Date until, but not including, the Maturity Date or such earlier repayment, prepayment or conversion. The accrual of Stated
Interest on the Loan as of any date will be calculated based on the Principal Amount of the Loan as of the Close of Business on the immediately
preceding Interest Payment Date (or, if no preceding Interest Payment Date, on the Closing Date). Accrued and unpaid Stated Interest
shall be payable quarterly in arrears on the Interest Payment Date, by adding all such accrued interest to the Principal Amount under
the Loan on such Interest Payment Date (such payment, a “PIK Interest Payment”), which addition of accrued interest
will be effective as of the Open of Business on such Interest Payment Date. Stated Interest and, if applicable, Additional Interest,
shall accrue and shall be computed daily on the basis of actual days elapsed over the number of calendar days per year (which shall be
365 days or 366 days, as applicable).
(ii) On
each Interest Payment Date, the Borrower shall make a record on its books and in the
Register
of any increase in the Principal Amount of the Loan due to the completion of a PIK Interest Payment, which addition of accrued interest
will be effective as of the Open of Business on such Interest Payment Date, the Loan shall represent the increased Principal Amount.
(B) Defaulted
Amounts. If the Borrower fails to pay any amount (a “Defaulted Amount”), payable on the Loan on or before the
due date therefor as provided in these Terms and Conditions, then, regardless of whether such failure constitutes an Event of Default,
(i) such Defaulted Amount will forthwith cease to be payable to the Lender otherwise entitled to such payment; (ii) to the extent lawful,
interest (“Default Interest”) will accrue on such Defaulted Amount at a rate per annum equal to the rate per annum
at which Stated Interest accrues, from, and including, such due date to, but excluding, the date of payment of such Defaulted Amount
and Default Interest; (iii) such Defaulted Amount and Default Interest will be paid on the next Interest Payment Date and the addition
of such Defaulted Amount and Default Interest will be effective as of the Open of Business on such Interest Payment Date. For the avoidance
of doubt, any payment of any Defaulted Amount and Default Interest shall be paid-in-kind consistent with the payment of Stated Interest
as described in Section 2.02(A)(i).
(C) Delay
of Payment when Payment Date is Not a Business Day. If the due date for a payment on the Loan as provided in these Terms and Conditions
is not a Business Day, then, notwithstanding anything to the contrary in these Terms and Conditions, such payment may be made on the
immediately following Business Day and no interest will accrue on such payment as a result of the related delay. Solely for purposes
of the immediately preceding sentence, a day on which the applicable place of payment is authorized or required by law or executive order
to close or be closed will be deemed not to be a “Business Day.”
Section
2.03. Register.
The
Borrower will keep a record (the “Register”) of the names and addresses of the Lender, the Principal Amount of the
Loan held by the Lender, any increase in the Principal Amount of the Loan due to a PIK Interest Payment and the transfer, assignment,
exchange, repayment and conversion of the Loan, if applicable. Absent manifest error, the entries in the Register will be conclusive.
The Register will be in written form or in any form capable of being converted into written form reasonably promptly.
Article
3. Covenants
Section
3.01. Payment Of The Loan.
The
Borrower will pay or cause to be paid all the Principal Amount of, and other amounts due with respect to, the Loan on the dates and in
the manner set forth in these Terms and Conditions, including, upon any conversion of the Loan, a number of Common Shares equal to quotient
obtained by dividing (x) $2,100,000 by (y) the Conversion Price then in effect (the “Conversion Fee Shares”). Notwithstanding
anything to the contrary in these Terms and Conditions, on the Maturity Date, the Loan shall be automatically converted in accordance
with Article 5 in satisfaction in full of the outstanding Principal Amount of the Loan and any accrued and unpaid interest thereon.
Section
3.02. Additional Amounts.
(A) Requirement
to Pay Additional Amounts. All payments and deliveries made by, or on behalf of, the Borrower under or with respect to the Loan (including
the PIK Interest Payment, payment of the Principal Amount of, the delivery of any Conversion Consideration due upon conversion of, the
Loan or the Conversion Fee Shares) will be made without withholding or deduction for, or on account of, any present or future Taxes,
unless such withholding or deduction is required by law or regulation or by governmental policy having the force of law. If any Taxes
levied by or on behalf of the Netherlands, Germany or any other jurisdiction (or any political subdivision or taxing authority thereof
or therein) in which the Borrower or any Successor Entity is, for tax purposes, organized or resident or doing business or through which
payment is made or deemed to be made (each such jurisdiction, subdivision or authority, as applicable, a “Relevant Taxing Jurisdiction”)
are required to be withheld or deducted from any payments or deliveries made under or with respect to the Loan, then the Borrower or
such Successor Entity, as applicable, will pay to the Lender such additional amounts (the “Additional Amounts”) as
may be necessary to ensure that the net amount received by the beneficial owner of such Loan after such withholding or deduction (and
after withholding or deducting any Taxes on the Additional Amounts) will equal the amounts that would have been received by such beneficial
owner had no such withholding or deduction been required; provided, however, that such obligation to pay Additional Amounts
will not apply to:
(i) any Tax that would not have been imposed but for:
(1) the
existence of any present or former connection between the Lender or beneficial owner of such Loan and the Relevant Taxing Jurisdiction
(other than merely holding or being a beneficial owner of such Loan or the receipt or enforcement of payments or deliveries thereunder),
including such Lender or beneficial owner being or having been a national, domiciliary or resident, or treated as a resident, of, or
being or having been physically present or engaged in a trade or business, or having had a permanent establishment, in, such Relevant
Taxing Jurisdiction; or
(2) the
failure of such Lender to comply with a timely request from the Borrower or the Successor Entity, addressed to such Lender, to (x) provide
certification, information, documentation or other evidence concerning such Lender’s nationality, residence, identity or connection
with such Relevant Taxing Jurisdiction; or (y) make any declaration or satisfy any other reporting requirement relating to such matters,
in each case if and to the extent that such Lender is legally entitled without material burden to comply with such request and due and
timely compliance with such request is required by statute, regulation or administrative practice of such Relevant Taxing Jurisdiction
in order to reduce or eliminate such withholding or deduction;
(ii)
any estate, inheritance, gift, sale, transfer, personal property or similar Tax;
(iii)
any tax that is payable other than by withholding or deduction from payments or
deliveries
under or with respect to the Loan;
(iv) any withholding or deduction required by (x) sections 1471 through 1474 of the Internal Revenue Code and any current or future
U.S. Treasury Regulations or rulings promulgated thereunder (“FATCA”); (y) any inter-governmental agreement between
the United States and any other non-U.S. jurisdiction to implement FATCA or any law enacted by such other jurisdiction to give effect
to such agreement; or (z) any agreement with the U.S. Internal Revenue Service pursuant to Section 1471(b)(1) of the Internal Revenue
Code;
(v) any
taxes imposed on or with respect to any payment by the Borrower to such Lender if such Lender is a fiduciary, partnership or person other
than the sole beneficial owner of such payment, to the extent that such payment would be required, under the laws of such Relevant Taxing
Jurisdiction, to be included for tax purposes in the income of a beneficiary or settlor with respect to such fiduciary, a partner or
member of such partnership, or a beneficial owner, who would not have been entitled to such Additional Amounts had such beneficiary,
settlor, partner, member or beneficial owner been the Lender thereof; or
(vi) any combination of items referred to in the preceding clauses (i) through (v), inclusive, above.
(B) Indemnification for Transfer Taxes. The Borrower will pay and indemnify each Lender for any present or future stamp, issue,
registration, transfer, court, documentary, excise or property Taxes (“Transfer Taxes”) levied by any Relevant Taxing
Jurisdiction in connection with the execution, delivery, registration, issuance or enforcement of the Loan or the receipt of any payments
or deliveries (including of any Conversion Consideration or the Conversion Fee Shares) with respect to the Loan; provided, however,
that, with respect to any such taxes attributable to the receipt of any payments or deliveries with respect to the Loan, Transfer Taxes
will not include those excluded under any combination of clauses (i), (ii), (iv) and (v) of Section 3.02(A).
(C) Indemnification for German Taxes. The Borrower will pay and indemnify each Lender for any present or future Taxes levied
by Germany on any payments (including PIK Interest Payments) under the Loan. The exceptions included in Section 3.02(A)(i)(1)
shall apply mutatis mutandis to the indemnity obligation of the Borrower under this Section 3.02(C).
(D) Tax Receipts. If the Borrower is required to make any deduction or withholding from any payments or deliveries with respect
to the Loan, then the Borrower will deliver to the applicable Lenders official tax receipts (or, if, after expending reasonable efforts,
the Borrower is unable to obtain such receipts, other evidence of payments reasonably acceptable to the Lenders) evidencing the remittance
to the relevant tax authorities of the amounts so withheld or deducted.
(E) Interpretation
of Terms and Conditions. All references in these Terms and Conditions to any payment on, or delivery with respect to, the Loan (including
payment of the Principal Amount of, the delivery of any Conversion Consideration due upon conversion of, the Loan or the Conversion Fee
Shares) will, to the extent that Additional Amounts are payable in respect thereof, be deemed to include the payment of such Additional
Amounts.
(F) Survival
of Obligations. The obligations set forth in this Section 3.02 will survive any
transfer
or assignment of the Loan by a Lender.
Section
3.03. Stay, Extension and Usury Laws.
To
the extent that it may lawfully do so, the Borrower (A) agrees that it will not at any time insist upon, plead, or in any manner whatsoever
claim or take the benefit or advantage of, any stay, extension or usury law (wherever or whenever enacted or in force) that may affect
the covenants or the performance of these Terms and Conditions; and (B) expressly waives all benefits or advantages of any such law and
agrees that it will not, by resort to any such law, hinder, delay or impede the execution of any power granted to the Lender by these
Terms and Conditions, but will suffer and permit the execution of every such power as though no such law has been enacted.
Section
3.04. Corporate Existence.
Subject
to Article 6, the Borrower will cause to preserve and keep in full force and effect:
(A) its corporate existence in accordance with the organizational documents of the Borrower; and
(B) the
material rights (charter and statutory), licenses and franchises of the Borrower and its Subsidiaries;
provided,
however, that the Borrower need not preserve or keep in full force and effect any such license or franchise if the Board of Managing
Directors determines that (x) the preservation thereof is no longer desirable in the conduct of the business of the Borrower and its
Subsidiaries, taken as a whole; and (y) the loss thereof is not, individually or in the aggregate, materially adverse to the Lender.
Section
3.05. Further Instruments and Acts.
The
Borrower will execute and deliver such further instruments and do such further acts as may be reasonably necessary or proper to more
effectively carry out the purposes of these Terms and Conditions.
Section
3.06. Additional Interest.
(A) Accrual of Additional Interest. Additional Interest, if any, will accrue on the Loan on each day, and in the circumstances,
set forth in the Registration Rights Agreement.
(B) Amount
and Payment of Additional Interest. Any Additional Interest that accrues on the Loan pursuant to Section 3.06(A) will be payable
on the same date and in the same manner as the Stated Interest on the Loan and will accrue at a rate per annum equal to one quarter of
one percent (0.25%) of the Principal Amount thereof for the first ninety (90) days on which Additional Interest accrues and, thereafter,
at a rate per annum equal to one half of one percent (0.50%) of the Principal Amount thereof. For the avoidance of doubt, any Additional
Interest that accrues on the Loan will be in addition to the Stated Interest that accrues on the Loan. For
the
avoidance of doubt, any payment of Additional Interest shall be paid-in-kind consistent with the payment of Stated Interest as described
in Section 2.02(A)(i).
(C) Notice
of Accrual of Additional Interest. The Borrower will send notice to the Lender of the commencement and termination of any period
in which Additional Interest accrues on the Loan. In addition, if Additional Interest accrues on the Loan, then, no later than five (5)
Business Days before each date on which such Additional Interest is to be paid, the Borrower will deliver an Officer’s Certificate
to the Lender stating (i) that the Borrower is obligated to pay Additional Interest on the Loan on such date of payment; and (ii) the
amount of such Additional Interest that is payable on such date of payment.
Article
4. Conversion
Upon A Fundamental Change
Section
4.01. Right of the Lender to Convert the Loan
Upon a Fundamental Change.
(A) Right of the Lender to Convert the Loan Upon a Fundamental Change. Subject to the other terms of this Section 4.01,
if a Fundamental Change occurs, then the Lender will have the right, but not the obligation, to convert all, but not less than all, of
the Loan on the Fundamental Change Conversion Date for such Fundamental Change at the Conversion Price.
(B) Fundamental
Change Conversion Date. The Fundamental Change Conversion Date for any Fundamental Change will be a Business Day of the Borrower’s
choosing that is no more than thirty five (35), nor less than twenty (20), Business Days after the date the Borrower sends the related
Fundamental Change Notice pursuant to Section 4.01(E). For the avoidance of doubt, the Lender will have the right, but not the
obligation, to convert all, but not less than all, of the Loan on the Fundamental Change Conversion Date.
(C) Conversion
Upon a Fundamental Change. In the event of a Fundamental Change, the Lender will have the right, but not the obligation, to convert
the Principal Amount of the Loan at the Close of Business on the Fundamental Change Conversion Date for such Fundamental Change and the
Conversion Consideration due in respect of the Principal Amount of the Loan to be converted will be a number of Common Shares equal to
the quotient obtained by dividing (1) the Principal Amount of the Loan plus accrued and unpaid interest (to the extent such accrued
and unpaid interest is not included in the Principal Amount) by (2) the Conversion Price then in effect on the Fundamental Change Conversion
Date for such conversion in accordance with the provisions under Section 5.02 and Section 5.03. Additionally, on any such
Fundamental Change Conversion Date, the Company shall deliver the Conversion Fee Shares to the Lender. For the avoidance of doubt, if
an Interest Payment Date is not a Business Day within the meaning of Section 2.02(C) and such Fundamental Change Conversion Date
occurs on the Business Day immediately after such Interest Payment Date, then the Principal Amount of the Loan will include interest
on the Loan to be converted from, and including, such Interest Payment Date.
(D)
[Reserved].
(E) Fundamental
Change Notice. On or before the twentieth (20th) calendar day after the
effective
date of a Fundamental Change, the Borrower will send to the Lender a notice of such Fundamental Change (a “Fundamental Change
Notice”).
Such
Fundamental Change Notice must state:
(i) briefly, the events causing such Fundamental Change;
(ii)
the effective date of such Fundamental Change;
(iii)
the Fundamental Change Conversion Date for such Fundamental Change;
(iv) the
(1) number of Common Shares consisting of the Conversion Consideration with respect to the Principal Amount of the Loan plus accrued
and unpaid interest on the Loan to, and including, such Fundamental Change Conversion Date for such Fundamental Change (to the extent
such accrued and unpaid interest is not included in the Principal Amount) for such Fundamental Change and (2) the Conversion Fee Shares;
(v) the
name and address of the Borrower; and
(vi) the
Conversion Price in effect on the date of such Fundamental Change Notice and a description and quantification of any adjustments to the
Conversion Price that may result from such Fundamental Change.
(F) [Reserved].
(G)
Conversion in Connection with a Fundamental Change in the Event of a Tender Offer. In the event of a Fundamental Change
pursuant to a Tender Offer for the outstanding Common Shares of the Borrower where the price offered in such Tender Offer is greater
than the Conversion Price then in effect, the Lender shall be required to convert the entirety of the Loan in accordance with Article
5 hereof. Additionally, the Lender shall be required, upon conversion, to (1) tender all of the Common Shares issued upon conversion
(and any other Common Shares then held by such Lender, if applicable) in such Tender Offer, (2) vote all such Common Shares in favor
of the relevant transaction and (3) take any and all steps reasonably necessary to support the completion of the relevant transaction
or series of related transactions in connection with such Fundamental Change; provided, however, the requirements in the
foregoing sentence shall not apply if the Lender makes a superior, competing offer for the Borrower.
Article
5. Conversion
Section
5.01. Right to Convert.
(A) Generally.
Subject to the provisions of this Article 5, the Lender may, at its option, convert the Loan into Conversion Consideration. Upon
conversion of the Loan, the Lender shall also receive Conversion Fee Shares, as described under Section 5.03(A)(i)(1).
(B) No Partial Conversions. Subject to the terms of these Terms and Conditions, the Loan may be converted in whole and not
in part.
(C) When
the Loan May Be Converted.
(i) Generally.
The Lender may convert the Loan in its entirety at any time after the date upon which the 30-day volume-weighted average price of the
Common Shares has been at least the Conversion Price per Common Share for at least 20 Trading Days (whether or not consecutive) during
a period of 30 consecutive Trading Days, ending on, and including such date, in each case until the Close of Business on the Scheduled
Trading Day immediately before the Maturity Date. For the avoidance of doubt, the Loan may also be converted, at the Lender’s option,
upon the occurrence of a Fundamental Change as described in Article 4.
(ii)
Limitations and Closed Periods. Notwithstanding anything to the contrary in these Terms and Conditions:
(1)
The Loan may be surrendered for conversion only after the Open of Business and before the Close of Business on a day that is a
Business Day; and
(2)
subject to Section 5.01(D), in no event may the Loan be converted after the Close of Business on the Scheduled Trading
Day immediately before the Maturity Date.
(D) Conversion
on Maturity Date. Notwithstanding anything to the contrary in these Terms and Conditions, on the Maturity Date, the Loan shall be
automatically converted in accordance with this Article 5 in satisfaction in full of the outstanding Principal Amount of the Loan
and any accrued and unpaid interest thereon. The Conversion Consideration delivered to the Lender on the Maturity Date shall be calculated
in accordance with Section 5.03(A)(i).
(E) Conversion
at Borrower’s Option. Notwithstanding anything to the contrary in these Terms and Conditions, the Borrower may, at its option,
convert the Loan into Conversion Consideration and at any time by providing written notice to the Lender; provided that, in the
event of such conversion at the Borrower’s option, the Conversion Consideration shall be calculated based on the amount of unpaid
interest that would be accrued through the Maturity Date, provided that, in no event, shall such accrued and unpaid interest be less
than the amount that would have accrued over six months at an annual interest rate of 13.77% on the Principal Amount of the Loan (or
$2.0 million). Additionally, upon conversion pursuant to this Section 5.01(E), the Borrower shall deliver the Conversion Fee Shares.
Section
5.02. Conversion Procedures.
(A) Generally.
To convert the Loan, the Lender must (1) complete, manually sign and deliver to the Borrower the conversion notice attached to these
Terms and Conditions or a facsimile of such conversion notice; (2) deliver such conversion notice to the Borrower (at which time such
conversion will become irrevocable); (3) furnish any endorsements and transfer documents that the Borrower may reasonably require (including
directions as to how and to which securities account Lender dictates the Common Shares comprised in the Conversion Consideration and
Conversion Fee Shares to be delivered); and (4) pay any amounts due pursuant to or Section 5.02(D). Clauses (1) and (2) of this
Section 5.02(A) shall not apply in the event the Lender elects to convert the Loan in its entirety in connection with a Fundamental
Change described in Article 4 or if the Loan is automatically converted at the Maturity Date pursuant to Section 5.01(D).
(B) Effect
of Converting the Loan. At the Close of Business on the Conversion Date or a Fundamental Change Conversion Date for the Loan to be
converted, the Loan will (unless there occurs a Default in the delivery of the Conversion Consideration, Conversion Fee Shares or interest
due, pursuant to Section 5.03(A), upon such conversion) be deemed to cease to be outstanding (and, for the avoidance of doubt,
no Person will be deemed to be a Lender as of the Close of Business on such Conversion Date or Fundamental Change Conversion Date, as
applicable, or have the ability to exercise any rights or remedies as a Lender).
(C) Holder
of Record of Conversion Shares. The Person in whose name any Common Share is issuable upon conversion of the Loan will be deemed
to become the holder of record of such share as of the Close of Business on the Conversion Date for such conversion.
(D) Taxes
and Duties. If the Lender converts the Loan (including at the Lender’s election upon a Fundamental Change) or when the Loan
is automatically converted at the Maturity Date pursuant to Section 5.01(D), the Borrower will pay any documentary, stamp
or similar issue or transfer tax or duty due on the issue of any Common Shares upon such conversion; provided, however,
that if any tax or duty is due because such Lender requested such shares to be registered in a name other than the Lender’s name,
then the Lender will pay such tax or duty and, until having received a sum sufficient to pay such tax or duty, the Borrower may refuse
to deliver any such shares to be issued in a name other than that of the Lender.
Section
5.03. Settlement Upon Conversion.
(A) Conversion
Consideration.
(i) Generally.
Subject to Section 5.03(A)(ii), the type and amount of consideration (the “Conversion Consideration”) due in
respect of the Principal Amount of the Loan to be converted will be a number of Common Shares equal to the quotient obtained by dividing
(1) the Principal Amount of the Loan plus accrued and unpaid interest by (2) the Conversion Price then in effect on the Conversion
Date or Fundamental Change Conversion Date for such conversion, plus the Conversion Fee Shares. On the Maturity Date, which, for
the avoidance of doubt, is deemed a Conversion Date, the Company shall deliver a number of Common Shares of the Company equal to the
quotient obtained by dividing (x) the Principal Amount of the Loan plus accrued and unpaid interest by (y) the Conversion Price
then in effect on the Maturity Date; provided, however, in no event on the Maturity Date shall the accrued and unpaid interest
described in the preceding clause (x) be less than the amount that would have accrued over six months at an annual interest rate of 13.77%
of the Principal Amount of the Loan (or $2.0 million). Additionally, the Conversion Fee Shares will be delivered on the Maturity Date.
(1)
The number of Conversion Fee Shares to be delivered upon any conversion of the Loan under these Terms and Conditions shall be
equal to the quotient obtained by dividing (x) $1,000,000 by (y) the Conversion Price then in effect on any Conversion Date or Fundamental
Change Conversion Date. For the avoidance of doubt, the Maturity Date is deemed a Conversion Date.
(ii) Cash
in Lieu of Fractional Shares. If the number of Common Shares deliverable pursuant to Section 5.03(A)(i) upon conversion of
the Loan is not a whole number, then such number will
be
rounded down to the nearest whole number and the Borrower will deliver, in addition to the other consideration due upon such conversion,
cash in lieu of the related fractional share in an amount equal to the product of (1) such fraction and (2) the Last Reported Sale Price
per Common Share on the Conversion Date or the Fundamental Change Conversion Date for such conversion (or, if such Conversion Date or
Fundamental Change Conversion Date is not a Trading Day, the immediately preceding Trading Day).
(iii)
[Reserved].
(B) Delivery
of the Conversion Consideration. Except as set forth in Section 5.05(B), and subject to the Lender having paid any amounts
due under Section 5.02(D) and Section 5.03(C), the Borrower will pay or deliver, as applicable, the Conversion Consideration
due upon the conversion of the Loan to the Lender plus the Conversion Fee Shares on or before the second (2nd) Business Day immediately
after the Conversion Date or the Fundamental Change Conversion Date for such conversion.
(C) Delivery of Nominal Value Payment to the Borrower Upon Conversion. Upon conversion of the Loan in accordance with (1) the
Articles of Association of the Borrower and (2) Section 5.02(A) hereof, the conversion notice shall be accompanied by an amount
in cash equal to the nominal value per Common Share for each Common Share such Lender is entitled to receive as Conversion Consideration
and Conversion Fee Shares upon conversion of the Loan. The Lender shall similarly be obligated to pay such amount in connection with
any automatic conversion of the Loan on the Maturity Date pursuant to Section 5.01(D), on any conversion of the Loan at the Borrower’s
option pursuant to Section 5.01(E) or upon the occurrence of a Fundamental Change pursuant to Article 4 (notwithstanding
the fact that no conversion notice shall be required in the event of a Fundamental Change as described in Section 5.02(A) or any
automatic conversion of the Loan on the Maturity Date pursuant to Section 5.01(D)). Notwithstanding the foregoing, the Borrower
may advance, on Lender’s behalf, any amounts necessary to ensure that the conversion of the Loan is not delayed by the foregoing
requirement (or any other requirement hereunder or under any applicable law) that the Lender pay the Borrower the nominal value per Common
Share for each Common Share such Lender is entitled to receive as Conversion Consideration and Conversion Fee Shares before the conversion
is complete; provided that, if the Borrower does advance any such amounts, the Lender shall repay the Borrower such amounts in
cash within five (5) Business Days of any such conversion.
(D) Settlement
of Accrued Interest Notwithstanding Conversion. The Borrower’s delivery of the Conversion Consideration and Conversion Fee
Shares due in respect of conversion of the Loan will be deemed to fully satisfy and discharge the Borrower’s obligation to pay
the Principal Amount of, and accrued and unpaid interest, if any (to the extent such accrued and unpaid interest is not included in the
Principal Amount), on the Loan to, but, excluding the Conversion Date or Fundamental Change Conversion Date, as applicable. As a result,
any accrued and unpaid interest on the converted Loan will be deemed to be paid in full rather cancelled, extinguished or forfeited.
Section
5.04. Reserve and Status of Common Shares Issued
Upon Conversion.
(A) Share
Reserve. At all times when the Loan is outstanding, the Borrower will not propose
at
any general meeting of the Borrower’s shareholders any reduction of the authorized share capital (“maatschappelijk kapitaal”)
such that it becomes insufficient to provide for the conversion of the Loan and will use its best efforts to ensure that its authorized
share capital (“maatschappelijk kapitaal”) is sufficient to permit the conversion of the then-outstanding Principal
Amount of the Loan. To the extent the Borrower delivers Common Shares held in its treasury in settlement of the conversion of the Loan,
each reference in these Terms and Conditions to the issuance of Common Shares in connection therewith will be deemed to include such
delivery, mutatis mutandis.
(B) Status
of Conversion Shares; Listing. Each Conversion Share delivered upon conversion of the Loan will be a newly issued or treasury share
and will be duly authorized, validly issued, fully paid, non-assessable (meaning that the holder of a Common Share shall not by reason
of merely being such a holder be subject to assessment or calls by the Company or its creditors for further payment on such Common Share),
free from preemptive rights and free of any lien or adverse claim (except to the extent of any lien or adverse claim created by the action
or inaction of the Lender or the Person to whom such Conversion Share will be delivered). The initial number of Conversion Shares to
be delivered upon conversion of the Loan is 15,000,000 (representing (i) a number of Common Shares of the Company equal to the quotient
obtained by dividing (x) the Principal Amount of the Loan plus accrued and unpaid interest (which, in no event shall be less than
$2,000,000) by (y) the Conversion Price plus (ii) the Conversion Fee Shares); provided, however, such amount is
subject to adjustment pursuant to Section 5.05 in accordance with the terms thereof. If the Common Shares are then listed on any
securities exchange, or quoted on any inter-dealer quotation system, then the Borrower will cause each Conversion Share, when delivered
upon conversion of the Loan, to be admitted for listing on such exchange or quotation on such system.
Section
5.05. Adjustments to the Conversion Price.
(A) Events
Requiring an Adjustment to the Conversion Price. The Conversion Price will be adjusted from time to time as follows (provided
that, for the avoidance of doubt, the conversion of the Loan in accordance with these Terms and Conditions will not result in an
adjustment of the Conversion Price):
(i) Share Dividends, Splits and Combinations. If the Borrower issues solely Common Shares as a dividend or distribution on
all or substantially all Common Shares, or if the Borrower effects a share split or a share combination of the Common Shares (in each
case excluding an issuance solely pursuant to a Common Shares Change Event, as to which Section 5.07 will apply), then the Conversion
Price will be adjusted based on the following formula:
where:
| CP0 |
= | the Conversion Price in effect
immediately before the Open of Business on the Ex-Dividend Date for such dividend or distribution, or immediately before the Open of
Business on the effective date of such share split or |
share
combination, as applicable;
| CP1 |
= | the Conversion Price in effect
immediately after the Open of Business on such Ex-Dividend Date or effective date, as applicable; |
| OS0 |
= | the number of Common Shares
outstanding immediately before the Open of Business on such Ex-Dividend Date or effective date, as applicable, without giving effect
to such dividend, distribution, share split or share combination; and |
| OS1 |
= | the number of Common Shares
outstanding immediately after giving effect to such dividend, distribution, share split or share combination. |
If any
dividend, distribution, share split or share combination of the type described in this Section 5.05(A)(i) is declared or announced,
but not so paid or made, then the Conversion Price will be readjusted, effective as of the date the Board of Managing Directors determines
not to pay such dividend or distribution or to effect such share split or share combination, to the Conversion Price that would then
be in effect had such dividend, distribution, share split or share combination not been declared or announced.
(ii)
Rights, Options and Warrants. If the Borrower distributes, to all or substantially all holders of Common Shares, rights,
options or warrants (other than (x) rights issued or otherwise distributed pursuant to a shareholder rights plan; or (y) pursuant to
an Initial Degressive Issuance or Degressive Issuance, as applicable, for which an adjustment to the Conversion Price is required (or
would be required without regard to Section 5.05(B)) pursuant to Section 5.05(A)(vi), entitling such holders, for a period
of not more than sixty (60) calendar days after the record date of such distribution, to subscribe for or purchase Common Shares at a
price per share that is less than the average of the Last Reported Sale Prices per Common Share for the ten (10) consecutive Trading
Days ending on, and including, the Trading Day immediately before the date such distribution is announced, then the Conversion Price
will be decreased based on the following formula:
where:
| CP0 |
= | the Conversion Price in effect
immediately before the Open of Business on the Ex-Dividend Date for such distribution; |
| CP1 |
= | the Conversion Price in effect
immediately after the Open of Business on such Ex-Dividend Date; |
| OS |
= | the
number of Common Shares outstanding immediately before the Open of Business on such Ex-Dividend
Date; |
| X |
= | the
total number of Common Shares issuable pursuant to such rights, options or warrants; and |
| Y |
= | a
number of Common Shares obtained by dividing (x) the aggregate price payable to exercise
such rights, options or warrants by (y) the average of the Last Reported Sale Prices per
Common Share for the ten (10) consecutive Trading Days ending on, and including, the Trading
Day immediately before the date such distribution is announced. |
To the
extent such rights, options or warrants are not so distributed, the Conversion Price will be readjusted to the Conversion Price that
would then be in effect had the increase to the Conversion Price for such distribution been made on the basis of only the rights, options
or warrants, if any, actually distributed. In addition, to the extent that Common Shares are not delivered after the expiration of such
rights, options or warrants (including as a result of such rights, options or warrants not being exercised), the Conversion Price will
be readjusted to the Conversion Price that would then be in effect had the decrease to the Conversion Price for such distribution been
made on the basis of delivery of only the number of Common Shares actually delivered upon exercise of such rights, option or warrants.
For purposes
of this Section 5.05(A)(ii), in determining whether any rights, options or warrants entitle holders of Common Shares to subscribe
for or purchase Common Shares at a price per share that is less than the average of the Last Reported Sale Prices per Common Share for
the ten (10) consecutive Trading Days ending on, and including, the Trading Day immediately before the date the distribution of such
rights, options or warrants is announced, and in determining the aggregate price payable to exercise such rights, options or warrants,
there will be taken into account any consideration the Borrower receives for such rights, options or warrants and any amount payable
on exercise thereof, with the value of such consideration, if not cash, to be determined by the Board of Managing Directors.
(iii)
Spin-Offs and Other Distributed Property.
(1)
Distributions Other than Spin-Offs. If the Borrower distributes its Capital Shares, evidences of its indebtedness or other
assets or property of the Borrower, or rights, options or warrants to acquire Capital Shares of the Borrower or other securities, to
all or substantially all holders of the Common Shares, excluding:
(t) any
distribution pursuant to an Initial Degressive Issuance or a Degressive Issuance for which an adjustment to the Conversion Price is required
(or would be required without regard to Section 5.05(B)) pursuant to Section 5.05(A)(vi), as applicable;
(u) dividends,
distributions, rights, options or warrants for which an adjustment to the Conversion Price is required (or would be required without
regard to Section 5.05(B)) pursuant to Section 5.05(A)(i)
or 5.05(A)(ii),
as applicable;
(v) dividends
or distributions paid exclusively in cash for which an adjustment to the Conversion Price is required (or would be required without regard
to Section 5.05(B)) pursuant to Section 5.05(A)(iv);
(w) rights
issued or otherwise distributed pursuant to a stockholder rights plan;
(x) Spin-Offs
for which an adjustment to the Conversion Price is required (or would be required without regard to Section 5.05(B)) pursuant
to Section 5.05(A)(iii)(2);
(y) a
distribution solely pursuant to a tender offer or exchange offer for Common Shares, as to which Section 5.05(A)(v) will apply;
and
(z) a
distribution solely pursuant to a Common Shares Change Event, as to which Section 5.07 will apply,
then the
Conversion Price will be decreased based on the following formula:
where:
| CP0 |
= | the Conversion Price in effect
immediately before the Open of Business on the Ex-Dividend Date for such distribution; |
| CP1 |
= | the Conversion Price in effect
immediately after the Open of Business on such Ex-Dividend Date; |
| SP |
= | the
average of the Last Reported Sale Prices per Common Share for the ten (10) consecutive Trading
Days ending on, and including, the Trading Day immediately before such Ex-Dividend Date;
and |
| FMV |
= | the
fair market value (as determined by the Board of Managing Directors), as of such Ex-Dividend
Date, of the Capital Shares, evidences of indebtedness, assets, property, rights, options
or warrants distributed per Common Share pursuant to such distribution; |
provided,
however, that if FMV is equal to or greater than SP, then, in lieu of the foregoing adjustment to the Conversion
Price, the Lender will receive, for each
Common
Share such Lender would have owned had such Lender converted the Loan on the record date for such distribution (which number of Common
Shares shall be equal to the quotient obtained by dividing (1) the Principal Amount of the Loan plus accrued and unpaid interest
by (2) the Conversion Price then in effect on such record date), at the same time and on the same terms as holders of Common Shares,
the amount and kind of Capital Shares, evidences of indebtedness, assets, property, rights, options or warrants distributed per one Common
Share.
To the
extent such distribution is not so paid or made, the Conversion Price will be readjusted to the Conversion Price that would then be in
effect had the adjustment been made on the basis of only the distribution, if any, actually made or paid.
(2)
Spin-Offs. If the Borrower distributes or dividends Capital Shares of any class or series, or similar equity interests,
of or relating to an Affiliate, a Subsidiary or other business unit of the Borrower to all or substantially all holders of the Common
Shares (other than solely pursuant to (x) a Common Shares Change Event, as to which Section 5.07 will apply; or (y) a tender offer
or exchange offer for Common Shares, as to which Section 5.05(A)(v) will apply), and such Capital Shares or equity interests are
listed or quoted (or will be listed or quoted upon the consummation of the transaction) on a U.S. national securities exchange (a “Spin-Off”),
then the Conversion Price will be decreased based on the following formula:
where:
| CP0 |
= | the Conversion Price in effect
immediately before the Close of Business on the last Trading Day of the Spin-Off Valuation Period for such Spin-Off; |
| CP1 |
= | the Conversion Price in effect
immediately after the Close of Business on the last Trading Day of the Spin-Off Valuation Period; |
| FMV |
= | the
product of (x) the average of the Last Reported Sale Prices per share or unit of the Capital
Shares or equity interests distributed in such Spin-Off over the ten (10) consecutive Trading
Day period (the “Spin-Off Valuation Period”) beginning on, and including,
the Ex-Dividend Date for such Spin-Off (such average to be determined as if references to
Common Shares in the definitions of Relevant Stock Exchange, Last Reported Sale Price, Trading
Day and Market Disruption Event were instead references to such Capital Shares or equity
interests); and (y) the number of shares or |
units of
such Capital Shares or equity interests distributed per Common Share in such Spin-Off; and
| SP |
= | the
average of the Last Reported Sale Prices per Common Share for each Trading Day in the Spin-Off
Valuation Period. |
Notwithstanding
anything to the contrary in this Section 5.05(A)(iii)(2), if the Conversion Date for the Loan to be converted occurs during the
Spin-Off Valuation Period for such Spin-Off, then, solely for purposes of determining the Conversion Consideration and Conversion Fee
Shares for such conversion, such Spin-Off Valuation Period will be deemed to consist of the Trading Days occurring in the period from,
and including, the Ex-Dividend Date for such Spin-Off to, and including, such Conversion Date.
To the
extent any dividend or distribution of the type set forth in this Section 5.05(A)(iii)(2) is declared but not made or paid, the
Conversion Price will be readjusted to the Conversion Price that would then be in effect had the adjustment been made on the basis of
only the dividend or distribution, if any, actually made or paid.
(iv)
Cash Dividends or Distributions. If any dividend or distribution of cash is made to all or substantially all holders of
Common Shares, then the Conversion Price will be decreased based on the following formula:
where:
| CP0 |
= | the Conversion Price in effect
immediately before the Open of Business on the Ex-Dividend Date for such dividend or distribution; |
| CP1 |
= | the Conversion Price in effect
immediately after the Open of Business on such Ex-Dividend Date; |
| SP |
= | the
Last Reported Sale Price per Common Share on the Trading Day immediately before such Ex-Dividend
Date; and |
| D |
= | the
cash amount distributed per Common Share in such dividend or distribution; |
provided,
however, that if D is equal to or greater than SP, then, in lieu of the foregoing adjustment to the Conversion Price,
the Lender will receive, for each Common Share such Lender would have owned had such Lender converted the Loan on the record date for
such dividend or distribution (which number of Common Shares shall be equal to the quotient obtained by dividing (1) the Principal Amount
of the Loan plus accrued and
unpaid
interest by (2) the Conversion Price then in effect on such record date), at the same time and on the same terms as holders of Common
Shares, the amount of cash distributed per one Common Share.
To the
extent such dividend or distribution is declared but not made or paid, the Conversion Price will be readjusted to the Conversion Price
that would then be in effect had the adjustment been made on the basis of only the dividend or distribution, if any, actually made or
paid.
(v)
Tender Offers or Exchange Offers. If the Borrower or any of its Subsidiaries makes a payment in respect of a tender offer
or exchange offer for Common Shares, and the value (determined as of the Expiration Time by the Board of Managing Directors) of the cash
and other consideration paid per Common Share in such tender or exchange offer exceeds the Last Reported Sale Price per Common Share
on the Trading Day immediately after the last date (the “Expiration Date”) on which tenders or exchanges may be made
pursuant to such tender or exchange offer (as it may be amended), then the Conversion Price will be decreased based on the following
formula:
where:
| CP0 |
= | the Conversion Price in effect immediately before the Close of Business on the last Trading Day
of the Tender/Exchange Offer Valuation Period for such tender or exchange offer; |
| CP1 |
= | the Conversion Price in effect immediately after the Close of Business on the last Trading Day
of the Tender/Exchange Offer Valuation Period; |
| AC |
= | the
aggregate value (determined as of the time (the “Expiration Time”) such
tender or exchange offer expires by the Board of Managing Directors) of all cash and other
consideration paid for Common Shares purchased or exchanged in such tender or exchange offer; |
| OS0 |
= | the number of Common Shares outstanding immediately before the Expiration Time (including all
Common Shares accepted for purchase or exchange in such tender or exchange offer); |
| OS1 |
= | the number of Common Shares outstanding immediately after the Expiration Time (excluding all
Common Shares accepted for purchase or exchange in such tender or exchange offer); and |
| SP |
= | the
average of the Last Reported Sale Prices per Common Share over the ten (10) consecutive Trading
Day period (the “Tender/Exchange Offer Valuation Period”) beginning on,
and including, the Trading Day |
immediately
after the Expiration Date;
provided,
however, that the Conversion Price will in no event be adjusted down pursuant to this Section 5.05(A)(v), except to the
extent provided in the immediately following paragraph. Notwithstanding anything to the contrary in this Section 5.05(A)(v), if
the Conversion Date for the Loan to be converted occurs during the Tender/Exchange Offer Valuation Period for such tender or exchange
offer, then, solely for purposes of determining the Conversion Consideration or the Conversion Fee Shares for such conversion, such Tender/Exchange
Offer Valuation Period will be deemed to consist of the Trading Days occurring in the period from, and including, the Trading Day immediately
after the Expiration Date to, and including, such Conversion Date.
To the
extent such tender or exchange offer is announced but not consummated (including as a result of the Borrower being precluded from consummating
such tender or exchange offer under applicable law), or any purchases or exchanges of Common Shares in such tender or exchange offer
are rescinded, the Conversion Price will be readjusted to the Conversion Price that would then be in effect had the adjustment been made
on the basis of only the purchases or exchanges of Common Shares, if any, actually made, and not rescinded, in such tender or exchange
offer.
(vi) Degressive Issuances. If, on or after the Closing Date, the Borrower or any of its Subsidiaries issues or otherwise sells
any Common Shares, or any Equity-Linked Securities, in each case at an Effective Price per Common Share that is less than the Conversion
Price in effect (before giving effect to the adjustment required by this Section 5.05(A)(vi)) as of the date of the issuance or
sale of such shares or Equity-Linked Securities (such an issuance or sale, a “Degressive Issuance”), then, effective
as of the Close of Business on such date, the Conversion Price will be decreased to an amount equal to the Weighted Average Issuance
Price. For these purposes, the “Weighted Average Issuance Price” will be equal to:
where:
| CP |
= | the
Conversion Price in effect immediately before giving effect to the adjustment required by
this Section 5.05(A)(vi); |
| OS |
= | the
number of Common Shares outstanding immediately before such Degressive Issuance; |
| EP |
= | the
Effective Price per share of Common Shares in such Degressive Issuance; and |
| X |
= | the
sum, without duplication, of (x) the total number of Common Shares issued or sold in such
Degressive Issuance; and (y) the maximum number of Common Shares underlying such Equity-Linked
Securities issued or |
sold
in such Degressive Issuance;
provided,
however, that (1) the Conversion Price will not be adjusted pursuant to this Section 5.05(A)(vi) solely as a result of
an Exempt Issuance; (2) the issuance of Common Shares pursuant to any such Equity-Linked Securities will not constitute an additional
issuance or sale of Common Shares for purposes of this Section 5.05(A)(vi) (it being understood, for the avoidance of doubt, that
the issuance or sale of such Equity-Linked Securities, or any re-pricing or amendment thereof, will be subject to this Section 5.05(A)(vi));
and (3) in no event will the Conversion Price be increased pursuant to this Section 5.05(A)(vi). For purposes of this Section
5.05(A)(vi), any re-pricing or amendment of any Equity-Linked Securities (including, for the avoidance of doubt, any Equity-Linked
Securities existing as of the Closing Date) will be deemed to be the issuance of additional Equity-Linked Securities, without affecting
any prior adjustments theretofore made to the Conversion Price. The Borrower will not effect any Degressive Issuance that would result
in an adjustment to the Conversion Price pursuant to this Section 5.05(A)(vi) that requires the approval of the Borrower’s
shareholders, unless the Borrower has obtained such shareholder approval before such Degressive Issuance.
(B) Adjustments Not Yet Effective. Notwithstanding anything to the contrary in these Terms and Conditions, if:
(i) the
Loan is to be converted;
(ii)
the record date, effective date or Expiration Time for any event that requires an adjustment to the Conversion Price pursuant
to Section 5.05(A) (but without regard to Section 5.05(A)(vi)) has occurred on or before the Conversion Date for such conversion,
but an adjustment to the Conversion Price for such event has not yet become effective as of such Conversion Date;
(iii)
the Conversion Consideration due upon such conversion includes any whole Common Shares; and
(iv)
such shares are not entitled to participate in such event (because they were not held on the related record date or otherwise),
then, solely for
purposes of such conversion, the Borrower will, without duplication, give effect to such adjustment on such Conversion Date. In such
case, if the date on which the Borrower is otherwise required to deliver the consideration due upon such conversion is before the first
date on which the amount of such adjustment can be determined, then the Borrower will delay the settlement of such conversion until the
second (2nd) Business Day after such first date.
(C) Conversion Price Adjustments where Converting Lenders Participate in the Relevant Transaction or Event. Notwithstanding
anything to the contrary in these Terms and Conditions, if:
(i) a Conversion Price adjustment for any dividend or distribution becomes effective on any Ex-Dividend Date pursuant to Section
5.05(A) (but without regard to Section 5.05(A)(vi));
(ii)
the Loan is to be converted;
(iii) the
Conversion Date for such conversion occurs on or after such Ex-Dividend Date and on or before the related record date;
(iv) the Conversion Consideration due upon such conversion includes any whole Common Shares based on a Conversion Price that is adjusted
for such dividend or distribution; and
(v) such
shares would be entitled to participate in such dividend or distribution (including pursuant to Section 5.02(C)),
then (x) such Conversion
Price adjustment will not be given effect for such conversion and (y) the Common Shares issuable upon such conversion based on such unadjusted
Conversion Price will be entitled to participate in such dividend or distribution.
(D) Limitation
on Effecting Transactions Resulting in Certain Adjustments. The Borrower will not engage in or be a party to any transaction or event
that would require the Conversion Price to be adjusted pursuant to Section 5.05(A) to an amount, if any, that, under applicable
law, would not permit the Common Shares issuable upon conversion to be legally issued and valid.
(E) Equitable
Adjustments to Prices. Whenever any provision of these Terms and Conditions requires the Borrower to calculate the average of the
Last Reported Sale Prices, or any function thereof, over a period of multiple days (including to calculate an adjustment to the Conversion
Price), the Borrower will make proportionate adjustments, if any, to such calculations to account for any adjustment to the Conversion
Price pursuant to Section 5.05(A)(i) that becomes effective, or any event requiring such an adjustment to the Conversion Price
where the Ex-Dividend Date or effective date, as applicable, of such event occurs, at any time during such period.
(F) Calculation
of Number of Outstanding Common Shares. For purposes of Section 5.05(A), the number of Common Shares outstanding at any time
will exclude Common Shares held in the Borrower’s treasury (unless the Borrower pays any dividend or makes any distribution on
Common Shares held in its treasury).
(G)
Calculations. All calculations with respect to the Conversion Price and adjustments thereto will be made to the nearest
cent.
(H)
Notice of Conversion Price Adjustments. Upon the effectiveness of any adjustment to the Conversion Price pursuant to Section
5.05(A), the Borrower will promptly send notice to the Lenders containing (i) a brief description of the transaction or other event
on account of which such adjustment was made; (ii) the Conversion Price in effect immediately after such adjustment; and (iii) the effective
time of such adjustment.
Section
5.06. Voluntary Adjustments.
(A)
Generally. To the extent permitted by law and applicable stock exchange rules, the Borrower, from time to time, may (but
is not required to) decrease the Conversion Price by any amount if (i) the Board of Managing Directors determines that such decrease
is either (x) in the best interest of the Borrower; or (y) advisable to avoid or diminish any income tax imposed on holders of Common
Shares or rights to purchase Common Shares as a result of any dividend or
distribution
of Common Shares (or rights to acquire Common Shares) or any similar event; (ii) such decrease is in effect for a period of at least
twenty (20) Business Days; and (iii) such decrease is irrevocable during such period.
(B)
Notice of Voluntary Decreases. If the Board of Managing Directors determines to decrease the Conversion Price pursuant
to Section 5.06(A), then, no later than the first Business Day of the related twenty (20) Business Day period referred to in Section
5.06(A), the Borrower will send notice to the Lender of such decrease, the amount thereof and the period during which such decrease
will be in effect.
Section
5.07. Effect of Common Shares Change Event.
(A)
Generally. If there occurs any:
(i) recapitalization, reclassification or change of the Common Shares (other than (x) changes solely resulting from a subdivision
or combination of the Common Shares, (y) a change only in par value or from par value to no par value or no par value to par value and
(z) share splits and share combinations that do not involve the issuance of any other series or class of securities);
(ii)
consolidation, merger, combination or binding or statutory share exchange involving the Borrower;
(iii)
sale, lease or other transfer of all or substantially all of the assets of the Borrower and its Subsidiaries, taken as a whole,
to any Person; or
(iv)
other similar event,
and, as a result
of which, the Common Shares are converted into, or are exchanged for, or represent solely the right to receive, other securities, cash
or other property, or any combination of the foregoing (such an event, a “Common Shares Change Event,” and such other
securities, cash or property, the “Reference Property,” and the amount and kind of Reference Property that a holder
of one (1) Common Share would be entitled to receive on account of such Common Shares Change Event (without giving effect to any arrangement
not to issue or deliver a fractional portion of any security or other property), a “Reference Property Unit”), then,
notwithstanding anything to the contrary in these Terms and Conditions,
(1) from
and after the effective time of such Common Shares Change Event, (I) the Conversion Consideration and the Conversion Fee Shares due upon
conversion of the Loan will be determined in the same manner as if each reference to any number of Common Shares in this Article 5
(or in any related definitions) were instead a reference to the same number of Reference Property Units; and (II) for purposes of
the definition of “Fundamental Change” references to “Common Shares” and the Borrower’s “common equity”
will be deemed to refer to the common equity (including depositary receipts representing common equity), if any, forming part of such
Reference Property; and
(2) for
these purposes, the Last Reported Sale Price of any Reference Property Unit or portion thereof that does not consist of a class of securities
will be the fair value of such Reference Property Unit or portion thereof, as applicable, determined in good
faith
and in a commercially reasonable manner by the Borrower (or, in the case of cash denominated in U.S. dollars, the face amount thereof).
If
the Reference Property consists of more than a single type of consideration to be determined based in part upon any form of shareholder
election, then the composition of the Reference Property Unit will be deemed to be the weighted average of the types and amounts of consideration
actually received, per Common Share, by the holders of Common Shares. The Borrower will notify the Lender of such weighted average as
soon as practicable after such determination is made.
At
or before the effective time of such Common Shares Change Event, the Borrower and the resulting, surviving or transferee Person (if not
the Borrower) of such Common Shares Change Event (the “Successor Person”) will execute and deliver to the Lender such
instrument(s) or other document(s) as may be necessary or reasonable to give effect to the provisions of this Section 5.07(A),
including to (x) provide for subsequent conversions of the Loan in the manner set forth in this Section 5.07; and (y) provide
for subsequent adjustments to the Conversion Price pursuant to Section 5.05(A) in a manner consistent with this Section 5.07.
If the Reference Property includes shares of stock or other securities or assets (other than cash) of a Person other than the Successor
Person, then such other Person will also execute such instrument(s) or other document(s) and the same will contain such additional provisions,
if any, that the Borrower reasonably determines are appropriate to preserve the economic interests of the Lender.
(B) Notice
of Common Shares Change Events. The Borrower will provide notice of each Common Shares Change Event to the Lender no later than the
effective date of such Common Shares Change Event.
(C) Compliance Covenant. The Borrower will not become a party to any Common Shares Change Event unless its terms are consistent
with this Section 5.07.
Article
6. Successors
Section
6.01. When the Borrower May Merge, Etc.
The
Borrower will not consolidate with or merge with or into, or (directly, or indirectly through one or more of its Subsidiaries) sell,
lease or otherwise transfer, in one transaction or a series of transactions, all or substantially all of the assets of the Borrower and
its Subsidiaries, taken as a whole, to another Person (a “Business Combination Event”), unless:
(A)
the resulting, surviving or transferee Person either (x) is the Borrower or (y) if not the Borrower, is a corporation (the “Successor
Entity”) duly organized and existing under the laws of the Netherlands or the laws of the United States of America, any State
thereof or the District of Columbia that expressly assumes (by executing and delivering to the Lender, at or before the effective time
of such Business Combination Event, such appropriate instrument(s) or other documentation) all of the Borrower’s obligations under
these Terms and Conditions (including, for the avoidance of doubt, the obligation to pay Additional Amounts pursuant to Section 3.02);
and
(B)
immediately after giving effect to such Business Combination Event, no Default or Event of Default will have occurred and be continuing.
Section
6.02. Successor Entity Substituted.
At
the effective time of any Business Combination Event that complies with Section 6.01, the Successor Entity (if not the Borrower)
will succeed to, and may exercise every right and power of, the Borrower under these Terms and Conditions with the same effect as if
such Successor Entity had been named as the Borrower in these Terms and Conditions, and, except in the case of a lease, the predecessor
Borrower will be discharged from its obligations under these Terms and Conditions and the other Transaction Documents.
Article
7. Defaults
and Remedies
Section
7.01. Events of Default.
(A)
Definition of Events of Default. “Event of Default” means the occurrence of any of the following:
(i) a default in the payment when due (whether at maturity or otherwise) of any accrued and unpaid interest, if any, on the Loan;
(ii)
the Borrower’s failure to deliver, when required by these Terms and Conditions, a Fundamental Change Notice, if such failure
is not cured within five (5) Business Days after its occurrence;
(iii)
a default in the Borrower’s obligation to convert the Loan in accordance with Article 4 or Article 5 upon
the exercise of the conversion right with respect thereto, which default continues for five (5) Business Days after its occurrence;
(iv)
a default in the Borrower’s obligations under Article 6;
(v) a default in any of the Borrower’s obligations or agreements under these Terms and Conditions or any other Transaction Document
(other than a default set forth in clause (i), (ii), (iii) or (iv) of this Section 7.01(A)) where
such default is not cured or waived within thirty (30) days after notice to the Borrower by the Lender, which notice must specify such
default, demand that it be remedied and state that such notice is a “Notice of Default”;
(vi)
a default by the Borrower or any of the Borrower’s Significant Subsidiaries with respect to any one or more mortgages, agreements
or other instruments under which there is outstanding, or by which there is secured or evidenced, any indebtedness for money borrowed
of at least five hundred thousand dollars ($500,000) (or its foreign currency equivalent) in the aggregate of the Borrower or any of
the Borrower’s Significant Subsidiaries, whether such indebtedness exists as of the Closing Date or is thereafter created, where
such default:
(1)
constitutes a failure to pay the principal of, or premium or interest on, any of such indebtedness when due and payable at its
stated maturity, upon
required
repayment, upon declaration of acceleration or otherwise; or
(2)
results in such indebtedness becoming or being declared due and payable before its stated maturity;
(vii)
one or more final judgments being rendered against the Borrower or any of the Borrower’s Significant Subsidiaries for the
payment of at least five hundred thousand dollars ($500,000) (or its foreign currency equivalent) in the aggregate (excluding any amounts
covered by insurance), where such judgment is not discharged or stayed within sixty (60) days after (i) the date on which the right to
appeal the same has expired, if no such appeal has commenced; or (ii) the date on which all rights to appeal have been extinguished;
(viii)
the Borrower denies or disaffirms its obligations under the Registration Rights Agreement;
(ix)
the Borrower or any of its Significant Subsidiaries, pursuant to or within the meaning of any Bankruptcy Law, either:
(1)
commences a voluntary case or proceeding;
(2)
consents to the entry of an order for relief against it in an involuntary case or proceeding;
(3)
consents to the appointment of a custodian of it or for any substantial part of its property;
(4)
makes a general assignment for the benefit of its creditors;
(5)
takes any comparable action under any foreign Bankruptcy Law; or
(6)
generally is not paying its debts as they become due; or
(x) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that either:
(1)
is for relief against the Borrower or any of its Significant Subsidiaries in an involuntary case or proceeding;
(2) appoints a custodian of the Borrower or any of its Significant Subsidiaries, or for any substantial part of the property of the
Borrower or any of its Significant Subsidiaries;
(3)
orders the winding up or liquidation of the Borrower or any of its Significant Subsidiaries; or
(4)
grants any similar relief under any foreign Bankruptcy Law,
and,
in each case under this Section 7.01(A)(x), such order or decree remains unstayed
and in
effect for at least sixty (60) days.
(xi) a
breach or default in the Borrower’s obligations or agreements under Section 6(a) (Right to Nominate Lender Director), Section 6(d)
(Use of Proceeds) or Section 6(f) (Indebtedness) of the Loan Agreement or under Section 2 (Certain New Securities; Preemptive Rights)
under the Preemptive Rights Agreement;
(xii)
an Event of Default (as defined in the Joint Venture Agreement) under Section 14 of the Joint Venture Agreement occurs (without
giving effect to the applicable grace or cure periods described therein) and any such Event of Default continues for a period of thirty
(30) days following such Event of Default.
(B) Cause
Irrelevant. Each of the events set forth in Section 7.01(A) will constitute an Event of Default regardless of the cause thereof
or whether voluntary or involuntary or effected by operation of law or pursuant to any judgment, decree or order of any court or any
order, rule or regulation of any administrative or governmental body.
Section
7.02. Acceleration.
If
an Event of Default occurs, then the Principal Amount of, and all accrued and unpaid interest on, the Loan then outstanding will become
due and payable without any further action or notice by any Person (x) with respect to an Event of Default under Section 7.01(A)(ix)
or Section 7.01(A)(x), immediately, and (y) with respect to any other Event of Default, at the election of the Lender by notice
to the Borrower.
Article
8. Miscellaneous
Section
8.01. Notices.
Any
notice or communication by the Borrower will be deemed to have been duly given (a) when delivered personally by hand (with written confirmation
of receipt), (b) when sent by e-mail, facsimile transmission, or other similar means of unsecured electronic communication (with written
confirmation of transmission) or (c) one Business Day following the day sent by overnight courier (with written confirmation of receipt),
in each case at the following addresses (or to such other address as the Borrower may have specified by notice given to the other Parties
pursuant to this provision):
Centogene
N.V.
Am Strande
7
18055 Rostock
Germany
Attention:
[***]
with a
copy (which will not constitute notice) to:
Davis Polk
& Wardwell London LLP
5 Aldermanbury
Square
London
EC2V 7HR
United
Kingdom
Attention:
Leo Borchardt
And
Davis Polk
& Wardwell LLP
450 Lexington
Avenue
New York,
NY 10017
United
States
Attention:
David Hahn
And
NautaDutilh
N.V.
Beethovenstraat
400
1082 PR
Amsterdam
The Netherlands
Attn: Paul
van der Bijl
Email:
Paul.vanderBijl@nautadutilh.com
The
Borrower or the Lender, by notice to the other, may designate additional or different addresses (including facsimile numbers and electronic
addresses) for subsequent notices or communications. The Borrower will record in the Register any such additional or different address
provided by the Lender.
All
notices or communications required to be made to a Lender pursuant to these Terms and Conditions must be made in writing and will be
deemed to be duly sent or given in writing if mailed by first class mail, certified or registered, return receipt requested, or by overnight
air courier guaranteeing next day delivery, to its address shown on the Register. The failure to send a notice or communication to a
Lender, or any defect in such notice or communication, will not affect its sufficiency with respect to any other Lender, if applicable.
All
notices and communications will be deemed to have been duly given: (A) at the time delivered by hand, if personally delivered; (B) five
(5) Business Days after being deposited in the mail, postage prepaid, if mailed; (C) when receipt acknowledged, if transmitted by facsimile,
electronic transmission or other similar means of unsecured electronic communication; and (D) the next Business Day after timely delivery
to the courier, if sent by overnight air courier guaranteeing next day delivery.
Section
8.02. No Personal Liability of Directors, Officers,
Employees and Shareholders.
No
past, present or future director, officer, employee, incorporator or shareholder of the Borrower, as such, will have any liability for
any obligations of the Borrower under these Terms and Conditions or for any claim based on, in respect of, or by reason of, such obligations
or their
creation and by
making the Loan pursuant to the Loan Agreement, the Lender waives and releases all such liability. Such waiver and release are part of
the consideration for assumption of the Loan on the part of the Borrower.
Section
8.03. Governing Law; Waiver of Jury Trial.
THESE
TERMS AND CONDITIONS, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THESE TERMS AND CONDITIONS, WILL BE GOVERNED
BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH OF BORROWER AND LENDER IRREVOCABLY WAIVES, TO THE FULLEST
EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THESE TERMS
AND CONDITIONS OR THE TRANSACTIONS CONTEMPLATED BY THESE TERMS AND CONDITIONS.
Section
8.04. Arbitration.
The
Borrower and each Lender agrees that any dispute, difference, claim, question or controversy arising out of or in connection with these
Terms and Conditions, which is not amicably settled between the Borrower and the Lender within a period of one month from the date of
the start of negotiations between the Borrower and the Lender, shall be finally resolved pursuant to arbitration pursuant to the terms
set forth in this Section 8.04. New York, New York will be the place of arbitration. Arbitration shall be governed by Judicial
Arbitration & Mediation Services (“JAMS”) and its JAMS Comprehensive Rules and Procedures (“JAMS Rules”)
in effect at the time the arbitration is commenced. A panel of three neutral arbitrators will be selected in accordance with the JAMS
Rules to conduct the arbitration. The arbitration shall be conducted in English. The arbitral award shall be final and enforced in any
court of competent jurisdiction by either party. To the extent permissible by applicable law, the Borrower and the Lender hereby waive
any right to appeal the decision of the arbitration. The arbitral tribunal may award legal costs and expenses as it deems fit. The Borrower
and the Lender hereby acknowledge and agree that arbitrators may issue procedural orders and decide on interim measures/injunctions in
the course of the arbitration. The Borrower and the Lender agree that any one of them may request in aid of arbitration from any court
of competent jurisdiction, injunctive relief or other conservatory measures. The Borrower and each Lender agrees that the fact of any
arbitration hereunder, the content of any such proceedings and the outcome thereof shall be treated as confidential and shall be held
confidential by either party and their respective Representatives.
Section
8.05. No Adverse Interpretation of Other Agreements.
These
Terms and Conditions may not be used to interpret any indenture, note, loan or debt agreement of the Borrower or its Subsidiaries or
of any other Person, and no such indenture, note, loan or debt agreement may be used to interpret these Terms and Conditions.
Section
8.06. Successors.
All
agreements of the Borrower in the Loan Agreement and these Terms and Conditions
will bind its successors.
Section
8.07. Calculations.
Except
as otherwise provided in these Terms and Conditions, the Borrower will be responsible for making all calculations called for under these
Terms and Conditions, including determinations of the Last Reported Sale Price, accrued interest on the Loan and the Conversion Price.
The
Borrower will make all calculations in good faith, and, absent manifest error, its calculations will be final and binding on the Lender.
The Borrower will provide a schedule of its calculations to the Lender upon request.
Section
8.08. Severability.
If
any provision of these Terms and Conditions or any other Transaction Document is invalid, illegal or unenforceable, then the validity,
legality and enforceability of the remaining provisions of these Terms and Conditions or the other Transaction Documents will not in
any way be affected or impaired thereby.
Section
8.09. Table of Contents, Headings, Etc.
The
table of contents and the headings of the Articles and Sections of these Terms and Conditions have been inserted for convenience of reference
only, are not to be considered a part of these Terms and Conditions and will in no way modify or restrict any of the terms or provisions
of these Terms and Conditions.
Section
8.10. Service of Process.
The
Borrower irrevocably appoints Centogene US, LLC, which currently maintains an office at 99 Erie St, Cambridge, MA 02139, United States
of America, as its authorized agent in the United States upon which process may be served in any suit, action or proceeding referred
to in Section 8.04, and agrees that service of process upon such agent, and written notice of such service to the Borrower by
the person serving the same to Centogene N.V., Am Strande 7, 18055 Rostock, Germany, Attention: [***], will be,
in every respect, effective service of process upon the Borrower in any such suit, action or proceeding. The Borrower agrees to take
any and all reasonable action as may be necessary to maintain such designation and appointment of such agent in full force and effect
until the date that is six (6) months after the Maturity Date. If, for any reason, such agent ceases to be such agent for service of
process, then the Borrower will promptly appoint a new agent of recognized standing for service of process in the United States and deliver
to the Lender a copy of the new agent’s acceptance of that appointment within ten (10) Business Days of such acceptance. Nothing
in this Section 8.10 will affect the right of the Lender to serve process in any other manner permitted by law or to commence
legal proceedings or otherwise proceed against the Borrower in any other court of competent jurisdiction. To the extent that the Borrower
has or hereafter may acquire any sovereign or other immunity from jurisdiction of any court or from any legal process with
respect to itself
or its property, the Borrower irrevocably waives such immunity in respect of its obligations under these Terms and Conditions.
[The Remainder
of This Page Intentionally Left Blank]
EXHIBIT A
FORM OF CONVERSION
NOTICE
CONVERSION NOTICE
CENTOGENE
N.V.
Loan
Subject
to the terms of the Terms and Conditions and the Loan Agreement, by executing and delivering this Conversion Notice, the undersigned
Lender identified below directs the Borrower to convert the entire Principal Amount (as defined in the Loan Agreement) of the Loan.
Date: |
|
|
|
|
|
|
(Legal
Name of Lender) |
EXHIBIT B
FORM OF ASSIGNMENT
ASSIGNMENT FORM
centogene
n.v.
Loan
Subject to the
terms of the Terms and Conditions, the undersigned Lender identified below assigns (check one):
| o | the
entire Principal Amount of |
| o | $
aggregate Principal Amount of |
the Loan and all
rights thereunder, to:
|
Social security or tax id. #: |
|
|
and
irrevocably appoints: |
|
as agent to transfer
and assign such Loan on the books of the Borrower. The agent may substitute another to act for him/her.
Date: |
|
|
|
|
|
|
(Legal
Name of Lender) |
Exhibit 99.3
Execution Version
PHARMACEUTICAL
INVESTMENT COMPANY
Alra’idah
Digital City, Building MU04, Al Nakhil District,
P.O. Box 6847, Riyadh
11452,
The Kingdom of Saudi
Arabia
October 26, 2023
Centogene N.V.
Am Strande 7
18055 Rostock
Germany
Re: Loan Agreement
– Preemptive Rights Agreement
Ladies and Gentlemen:
This
preemptive rights agreement (this “Agreement”) sets forth the agreements between Centogene N.V., a public company
with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (“Borrower”),
and Pharmaceutical Investment Company, a closed joint stock company incorporated pursuant to the laws of the Kingdom of Saudi Arabia
(together with its successors and/or permitted assigns, “Lender”), relating to certain rights, obligations and other
matters set forth herein in connection with Borrower and Lender’s entry into that certain Loan Agreement, dated as of the date
hereof, by and between Borrower and Lender (as may be amended, restated, amended and restated, modified or supplemented in accordance
with its terms from time to time, the “Loan Agreement”), and is to be effective as of the Closing Date (as defined
in the Loan Agreement). Lender and Borrower are each referred to herein as a “Party” and collectively as the “Parties”.
1. Defined
Terms.
(a)
Capitalized terms used but not otherwise defined herein shall have the meanings given thereto
in the Loan Agreement.
(b)
The following capitalized terms shall be defined herein as follows:
“Affiliate”
has the meaning set forth in Rule 144 of the Securities Act as in effect on the date hereof.
“Agreement”
has the meaning set forth in the preamble of this Agreement.
“Borrower”
has the meaning set forth in the preamble of this Agreement.
“Business
Day” means any day other than a Saturday, a Sunday or any day on which banking institutions in New York City, United States,
Riyadh, Saudi Arabia or Frankfurt am Main, Germany are authorized or required by Law or executive order to close or be closed.
“Capital
Shares” of any Person means any and all shares of, interests in, rights to purchase, warrants or options for, participations
in, or other equivalents of, in each case however designated, the equity of such Person, but excluding any debt securities convertible
into such equity.
“Convertible
Securities” has the meaning set forth in Section 2(a)(i).
“Common
Shares” means the common shares, par value €0.12 per share, of Borrower.
“Equity
Securities” has the meaning set forth in Section 2(a)(ii).
“Exchange
Act” means the U.S. Securities Exchange Act of 1934, as amended.
“Excluded
Securities” has the meaning set forth in Section 2(a)(iii).
“Fundamental
Change” means any of the following events:
(a)
the acquisition by any party (or parties acting in concert) of Common Shares representing more than 50% of the voting power of all of
Borrower’s Common Shares;
(b)
the consummation of (i) any sale, lease or other transfer, in one transaction or a series of related transactions, of all or substantially
all of the assets of Borrower and its Subsidiaries, taken as a whole, to any Person; or (ii) any transaction or series of related transactions
in connection with which (whether by means of merger, demerger, consolidation, share exchange, business combination, reclassification,
recapitalization, acquisition, liquidation or otherwise), the result of which is Borrower’s shareholders prior to any transaction
described in clause (i) or (ii) cease to own more than 50% of all classes of common equity of Borrower or its successor
following any such transaction; or
(c)
Borrower’s shareholders approve any plan or proposal for the liquidation or dissolution of Borrower;
provided,
however, that a transaction or event described in clause (a) or (b) above will not be deemed to constitute a Fundamental
Change if the Specified Shareholders each continue, immediately after such transaction or event described in clause (a) or (b)
to be the direct or indirect “beneficial owner” (as defined below) of substantially the same number of Common Shares
of Borrower (or replacement equity interests in the surviving entity, acquirer, successor, or transferee, as applicable (or the parent
entity thereof)) as each “beneficially owned” as of the date hereof.
For
the purposes of this definition, whether a Person is a “beneficial owner,” and whether shares are “beneficially owned,”
will be determined in accordance with Rule 13d-3 under the Exchange Act.
“Governmental
Entity” means (a) any supranational, national, federal, state, provincial, municipal, local or foreign government, governmental
authority, regulatory or administrative agency, governmental commission, department, board, bureau, agency, instrumentality, any court,
tribunal, arbitrator, mediator or other governmental official, authority or instrumentality and (b) any entity to whom a Governmental
Entity has assigned or delegated any authority or oversight responsibilities, including any notified body accredited, designated, licensed,
authorized or approved to assess and certify the conformity of a medical device (including in vitro diagnostic medical device) with the
requirements of the In Vitro Diagnostic Medical Devices Directive 98/79/EC, the In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746,
and applicable harmonized standards.
“JAMS”
has the meaning set forth in Section 9.
“JAMS
Rules” has the meaning set forth in Section 9.
“Lender”
has the meaning set forth in the preamble of this Agreement.
“Law”
means any statute, law, ordinance, rule, regulation, code, approval, license, Permit or Order, in each case, of any Governmental Entity.
“Loan”
means the convertible loan made by Lender to Borrower pursuant to the Loan Agreement.
“Loan
Agreement” has the meaning set forth in the preamble of this Agreement.
“Nasdaq”
means The Nasdaq Stock Market LLC.
“New
Securities” has the meaning set forth in Section 2(a)(iv).
“Offer”
has the meaning set forth in Section 2(b).
“Offer
Period” has the meaning set forth in Section 2(b).
“Options”
has the meaning set forth in Section 2(a)(v).
“Party”
or “Parties” has the meaning set forth in the preamble of this Agreement.
“Person”
means an individual, corporation, partnership, limited liability company, joint venture, trust or unincorporated organization or a Governmental
Entity.
“ROFO
Agreement” means that certain ROFO Agreement, dated as of October 26, 2023, between Lender, DPE Deutsche Private Equity GmbH,
Careventures Fund II S.C.Sp, and TVM Life Science Innovation I, L.P., as the same may be amended or supplemented from time to time.
“Registration
Rights Agreement” means that certain Registration Rights Agreement, dated as of October 26, 2023, between Borrower and Lender,
as the same may be amended or supplemented from time to time.
“Representatives”
means with respect to any Person, such Person’s Affiliates and its and their respective directors, officers, employees, agents,
insurance providers, and legal and financial advisors.
“Securities
Act” means the U.S. Securities Act of 1933, as amended.
“Specified
Shareholder” means, collectively, (a) DPE Deutsche Private Equity GmbH, (b), Careventures Fund II S.C.Sp, and (c) TVM Life
Science Innovation I, L.P.
“Subsidiary”
means, with respect to any Person, (a) any corporation, association or other business entity (other than a partnership or limited liability
company) of which more than 50% of the total voting power of the Capital Shares entitled (without regard to the occurrence of any contingency,
but after giving effect to any voting agreement or shareholders’ agreement that effectively transfers voting power) to vote in
the election of directors, managers or trustees, as applicable, of such corporation, association or other business entity is owned or
controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of such Person; and (b) any partnership or
limited liability company where (i) more than 50% of the capital accounts, distribution rights, equity and voting interests, or of the
general and limited partnership interests, as applicable, of such partnership or limited liability company are owned or controlled, directly
or indirectly, by such Person or one or more of the other Subsidiaries of such Person, whether in the form of membership, general, special
or limited partnership or limited liability company interests or otherwise; and (ii) such Person or any one or more of the other Subsidiaries
of such Person is a controlling general partner of, or otherwise controls, such partnership or limited liability company.
“Supervisory
Board of Directors” means the supervisory board of directors of Borrower.
“Transaction
Documents” means, collectively, this Agreement, the Loan Agreement, the ROFO Agreement, and the Registration Rights Agreement.
“Underlying
Shares” means the Common Shares issuable upon conversion of the Loan.
2. Certain
New Securities; Preemptive Rights.
(a)
For purposes of this Section 2, the following terms shall have the following
meanings:
| (i) | “Convertible
Securities” means any security convertible into or exchangeable for Common Shares. |
| (ii) | “Equity
Securities” means (A) all Capital Shares of Borrower or its Subsidiaries, (B) all
securities convertible into or exchangeable for Capital Shares of Borrower or its Subsidiaries
and (C) all options, warrants or other rights to purchase or otherwise acquire from Borrower
or its Subsidiaries such Capital Shares, or securities convertible into or exchangeable for
Capital Shares. |
| (iii) | “Excluded
Securities” means (A) any Capital Shares or options to purchase shares of Capital
Shares, or other equity-based awards (including restricted stock units), issued or granted
to employees (or prospective employees who have accepted an offer of employment), directors
or consultants of Borrower or any of its Subsidiaries, pursuant to plans that have been approved
by a majority of the independent members of the Supervisory Board of Directors or that exist
as of the date of this Agreement; (B) securities issued by Borrower or its Subsidiaries upon
the exercise, exchange or conversion of any securities that are exercisable or exchangeable
for, or convertible into, Capital Shares and are outstanding as of the date of this Agreement,
provided that such exercise, exchange or conversion is effected pursuant to the terms of
such securities as in effect on the date of this Agreement; (C) any securities issued as
a result of any Common Share split, reclassification or reorganization; (D) securities (including
Common Shares or Convertible Securities) issued pursuant to a bona fide public offering,
or Convertible Securities or Common Shares issuable upon exercise or conversion of Convertible
Securities issued pursuant to a bona fide public offering; provided, that the
foregoing exception in clause (D) shall only apply so long as Borrower remains listed
on Nasdaq, and (E) the Loan and Underlying Shares. For purposes of this definition, “consultant”
means a consultant that may participate in an “employee benefit plan” in accordance
with the definition of such term in Rule 405 under the Securities Act. |
| (iv) | “New
Securities” means all Equity Securities other than: (A) Excluded Securities;
(B) Capital Shares of Borrower issued on a pro rata basis to all holders of such class as
a share dividend; (C) Capital Shares of Borrower issued as consideration in connection with
the acquisition, approved by the Supervisory Board of Directors, by Borrower of assets or
Capital Shares of any Person; and (D) rights issued pursuant to a shareholder rights plan. |
| (v) | “Options”
means any options, warrants or other rights to subscribe for or to purchase, or any options
for the purchase of, any Common Shares or Convertible Securities. |
(b)
Following the consummation of any Fundamental Change (including any take private transaction),
and for so long as Lender holds at least 10% of the outstanding Common Shares of Borrower, including, prior to conversion, on an as-converted
basis, if Borrower intends to issue New Securities to any Person, then, at least 20 Business Days prior to the issuance of the New Securities,
Borrower shall deliver to Lender an offer (the “Offer”) to issue the New Securities to Lender upon the terms set forth
in this Section 2. The Offer shall state that Borrower proposes to issue New Securities and shall specify the
number and material terms (including the timing for the proposed issuance and the proposed purchase price) of the New Securities proposed
to be issued. The Offer shall remain open and irrevocable for a period of 15 Business Days (the “Offer Period”) from
the date of its delivery to Lender.
(c)
Upon receipt of the Offer described in the foregoing paragraph, Lender shall have the right
to purchase up to that portion of such New Securities equal to the quotient determined by dividing (x) the number of Common Shares held
by Lender (including, prior to conversion, on an as-converted basis) by (y) the total number of Common Shares then outstanding. The closing
of the purchase of New Securities by Lender shall be held at the principal offices of Borrower on the closing date set forth in the Offer
or at such other time and place as Borrower and Lender may agree. At such closing, Borrower shall issue and deliver the New Securities
to Lender against payment of the purchase price therefor by Lender. At such closing, Borrower and Lender shall execute such additional
documents as are otherwise reasonably necessary or appropriate to consummate the closing of the issuance and sale of the New Securities.
(d)
If Lender does not elect to purchase all or a portion of the New Securities available to
Lender pursuant to Section 2(c), Borrower may issue and sell all or any of such New Securities not purchased by Lender,
together with all other New Securities proposed to be issued as set out in the Offer, as applicable, to the applicable purchaser at a
purchase price that is not more favorable, and on other terms and conditions that are not more favorable in any material respect, than
those set forth in the Offer. If such sale is not consummated within 90 days of the date upon which the Offer is delivered to Lender
in accordance with this Section 2 (which 90-day period shall be extended, if required, in order for the relevant parties to obtain
any required approval of any Governmental Entity; provided, that such extension shall in no event extend for a period longer than
270 days after the date upon which the Offer is delivered to Lender), then Borrower’s right under this Section 2(d) to freely
issue and sell such New Securities shall terminate and Borrower shall again comply with Section 2(c) in respect of
any proposed issuance of New Securities.
3. Survival. Each Party’s obligations and covenants made in this Agreement shall
survive.
4. Entire Agreement; Amendment; Waiver. This Agreement and the other Transaction Documents
(including any schedules and exhibits hereto and thereto) represent the entire understanding and agreement between the Parties hereto
with respect to the subject matter hereof. Nothing expressed or implied in this Agreement is intended or shall be construed so as to
grant or confer on any person, firm or corporation other than the Parties hereto, any rights or privileges hereunder. This Agreement
can be amended, supplemented or changed, and any provision hereof can be waived, only by written instrument making specific reference
to this Agreement signed by the Party against whom enforcement of any such amendment, supplement, modification or waiver is sought. No
action taken pursuant to this Agreement shall be deemed to constitute a waiver by the Party taking such action of compliance with any
agreement contained herein. The waiver by any Party hereto of a breach of any provision of this Agreement shall not operate or be construed
as a further or continuing waiver of such breach or as a waiver of any other or
subsequent
breach. No failure on the part of any Party to exercise, and no delay in exercising, any right, power or remedy hereunder shall operate
as a waiver thereof, nor shall any single or partial exercise of such right, power or remedy by such Party preclude any other or further
exercise thereof or the exercise of any other right, power or remedy.
5. Assignability. Neither this Agreement nor any right, remedy, obligation or liability
arising hereunder or by reason hereof will be assignable by either Party without the prior written consent of the other Party; provided,
however, that Lender may assign any of its rights, remedies, obligations or liabilities arising under this Agreement to its Permitted
Transferees (as defined in the Loan Agreement).
6. Further Instruments and Acts. Each of the Parties to this Agreement agrees to execute
and deliver such further instruments and do such further acts as may be reasonably necessary or proper to more effectively carry out
the purposes of this Agreement.
7. Waiver
of Jury Trial. EACH OF BORROWER AND LENDER IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY WITH RESPECT TO ANY LEGAL PROCEEDING
ARISING OUT OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT.
8. Governing
Law. This Agreement will be governed by and construed in accordance with the internal laws of the State of New York.
9. Arbitration. Each Party agrees that any dispute, difference, claim, question or controversy
arising out of or in connection with this Agreement, which is not amicably settled between the Parties hereto within a period of one
month from the date of the start of negotiations between the Parties, shall be finally resolved pursuant to arbitration pursuant to the
terms set forth in this Section 9. New York, NY will be the place of arbitration. Arbitration shall be governed by
Judicial Arbitration & Mediation Services (“JAMS”) and its JAMS Comprehensive Rules and Procedures (“JAMS
Rules”) in effect at the time the arbitration is commenced. A panel of three neutral arbitrators will be selected in accordance
with the JAMS Rules to conduct the arbitration. The arbitration shall be conducted in English. The arbitral award shall be final and
enforced in any court of competent jurisdiction by either Party. To the extent permissible by Law, the Parties hereby waive any right
to appeal the decision of the arbitration. The arbitral tribunal may award legal costs and expenses as it deems fit. The Parties hereby
acknowledge and agree that arbitrators may issue procedural orders and decide on interim measures/injunctions in the course of the arbitration.
The Parties hereunder agree that any one of them may request in aid of arbitration from any court of competent jurisdiction, injunctive
relief or other conservatory measures. The Parties hereto hereby agree that the fact of any arbitration hereunder, the content of any
such proceedings and the outcome thereof shall be treated as confidential and shall be held confidential by each Party and their respective
Representatives in accordance with Section 17.
10. Expenses. Each of the Parties shall bear all of its own costs and expenses incurred
in connection with transactions contemplated by this Agreement and the other Transaction Documents, including without limitation, legal
and meeting expenses and costs in connection with the preparation of this Agreement and the other Transaction Documents and any filing
expenses with respect to the Transaction Documents.
11. Counterparts.
This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including .pdf or any electronic
signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
12. Notices.
All notices and other communications under this Agreement shall be in writing and shall be deemed given (a) when delivered personally
by hand (with written confirmation of receipt), (b) when sent by e-mail (with written confirmation of transmission) or (c) one Business
Day following the day sent by overnight courier (with written confirmation of receipt), in each case at the following addresses and facsimile
numbers (or to such other address or facsimile number as a Party may have specified by notice given to the other Party pursuant to this
provision):
If
to Borrower:
Centogene
N.V.
Am
Strande 7
18055
Rostock
Germany
Attn:
[***]
Email:
[***]
with
a copy to (which shall not constitute notice):
Davis
Polk & Wardwell London LLP
5
Aldermanbury Square
London
EC2V 7HR
Attn: Leo Borchardt
Email: leo.borchardt@davispolk.com
If
to Lender:
Alra’idah
Digital City, Building MU04, Al Nakhil District,
P.O.
Box 6847, Riyadh 11452,
The
Kingdom of Saudi Arabia
Attn:
[***]
Email: [***]
with
a copy to (which shall not constitute notice):
Latham
& Watkins LLP
Al-Tatweer
Towers, 7th Floor, Tower 1
King
Fahad Highway, PO Box 17411
Riyadh
11484, Saudi Arabia
Attn:
Ahmed el-Gaili, David Zaheer, and Gregory P. Rodgers
Email: Ahmed.el-Gaili@lw.com
david.zaheer@lw.com
Greg.Rodgers@lw.com
13. Binding
Effect. The provisions of this Agreement will be binding upon and accrue to the benefit of the Parties hereto and their respective
heirs, legal representatives, successors and permitted assigns.
14. No
Third Party Beneficiaries. This Agreement is for the sole benefit of the Parties hereto and their successors and permitted assigns
and nothing expressed or referred to in this Agreement will be construed to give any Person, other than the Parties to this Agreement
and such permitted assigns, any legal or equitable right, remedy or claim under or with respect to this Agreement or any provision of
this Agreement, whether as third party beneficiary or otherwise.
15. Severability. If any term or provision of this Agreement is invalid, illegal or unenforceable
in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other term or provision of this Agreement or
invalidate or render unenforceable such term or provision in any other jurisdiction.
16. Interpretation.
Any reference to a contract, instrument or other document as of a given date means the contract, instrument or other document as amended,
supplemented and modified from time to time through such date. The headings contained in this Agreement are for convenience of reference
only and will not affect the meaning or interpretation of this Agreement. All preamble, recital, article, section, exhibit and schedule
references are to the preambles, recitals, articles, sections, exhibits and schedules of this Agreement unless otherwise specified. All
references in this Agreement to “dollars” or “$” are to U.S. dollars. All payments to be made in cash under this
Agreement or under any other Transaction Document are to be paid in U.S. dollars. All references in this Agreement to any period of days
will mean the relevant number of calendar days unless otherwise specified. When calculating the period of time before which, within which
or following which, any act is to be done or step taken pursuant to this Agreement, the date that is the reference date in calculating
such period will be excluded. If the last day of any period is a non-Business Day, the period in question will end on the next succeeding
Business Day. Words in the singular will be held to include the plural and vice versa. Words of one gender will be held to include the
other genders and neutral as the context requires. The terms “hereof,” “herein,” “hereunder,” “hereto”
and “herewith” and words of similar import will, unless otherwise stated, be construed to refer to this Agreement and not
to any particular provision of this Agreement. The word “including” and words of similar import when used in this Agreement
will mean “including, without limitation,” unless otherwise specified. The word “or” will not be exclusive. The
Parties acknowledge and agree that each has negotiated and reviewed the terms of this Agreement, assisted by such legal and tax counsel
as they desired, and has contributed to its revisions. The Parties further agree that the rule of construction that any ambiguities are
resolved against the drafting Party will be subordinated to the principle that the terms and provisions of this Agreement will be construed
fairly as to all Parties and not in favor of or against any Party.
17. Confidentiality.
Neither Party hereto nor any of its Representatives may make any press release or other public disclosure regarding the existence of
this Agreement, its contents, or the transactions contemplated by this Agreement without the written consent of the other Party, in any
case, as to the form, content, and timing and manner of distribution or publication of such press release or other public disclosure
(which consent may not be unreasonably withheld, conditioned, or delayed). Each Party shall hold confidential the terms and provisions
of this Agreement and the terms of the transactions contemplated by this Agreement. Notwithstanding the foregoing, nothing in this Section
17 will prevent either Party or its Representatives from making any press release or other disclosure (a) required by Law or the
rules of any stock exchange, in which case the Party required to make such press release or other disclosure shall use commercially reasonable
efforts to allow the other Party reasonable time to review and comment on such release or disclosure in advance of its issuance or (b)
to the accountants, Representatives, stockholders, members and partners of such Party and its Affiliates as necessary in connection with
the ordinary conduct of their businesses (so long as such Persons agree to keep the terms of this Agreement confidential).
[Signature Page
Follows]
The undersigned
hereby execute and deliver this Agreement as of the date first set forth above.
|
Lender: |
|
|
|
PHARMACEUTICAL INVESTMENT COMPANY |
|
|
|
By: |
/s/ Ibrahim Abdulrahman I Aljuffali |
|
|
Name: Dr. Ibrahim Abdulrahman I Aljuffali |
|
|
Title: Chairman |
|
Borrower: |
|
|
|
CENTOGENE N.V. |
|
|
|
By: |
/s/ Kim Stratton |
|
|
Name: Kim Stratton |
|
|
Title: Chief Executive Officer |
Signature Page to Preemptive Rights Agreement
Exhibit 99.4
Execution Version
Centogene N.V.
Second Registration
Rights Agreement
October 26, 2023
Table of Contents
Page
Section
1. Definitions |
1 |
Section
2. Rules of Construction |
7 |
Section
3. General Resale Registration Statement |
8 |
(a) Filing
and Effectiveness of General Resale Registration Statement |
8 |
(b) Contents
of and Requirements for General Resale Registration Statement |
8 |
(c) Obligation
to Make Filings to Name Additional Notice Holders |
9 |
(d) Filing
of New General Resale Registration Statement; Designation of Existing Registration Statement |
10 |
(e) Where
SEC Rules Do Not Require Naming Selling Securityholders |
10 |
Section
4. Demand Underwriting Registration Rights |
10 |
(a) Right
to Demand Underwriting Registrations |
10 |
(b) Contents
of Demand Registration Notice |
11 |
(c) Participation
by Notice Holders Other Than the Demanding Notice Holder(s) |
11 |
(d) Certain
Procedures Relating to Demand Underwritten Offerings |
12 |
(e) Conditions
Precedent to Inclusion of a Notice Holder’s Registrable Securities |
13 |
(f) Priority
of Securities in Demand Underwritten Offerings |
13 |
(g) Covenant
Regarding Piggyback Rights with Respect to Demand Underwritten Offering |
14 |
Section
5. Piggyback Registration Rights |
14 |
(a) Notice
of Piggyback Underwritten Offering and Right to Participate Therein |
14 |
(b) Certain
Procedures Relating to Piggyback Underwritten Offerings |
14 |
(c) Conditions
Precedent to Inclusion of a Notice Holder’s Registrable Securities |
15 |
(d) Priority
of Securities in Piggyback Underwritten Offerings |
15 |
(e) Filing
of General Shelf Registration Statements |
16 |
(f) Notice
of General Shelf Registration Statements and Right to Participate Therein |
17 |
Section
6. Blackout Periods |
17 |
(a) Generally |
17 |
(b) Limitation
on Blackout Periods |
18 |
(c) Borrower
Representation Regarding Material Non-Public Information |
18 |
Section
7. Certain Registration and Related Procedures |
18 |
(a) Compliance
with Registration Obligations and Securities Act; SEC Staff Comments |
18 |
(b) Opportunity
for Review |
18 |
(c) Blue
Sky Qualification |
18 |
(d) Prevention
and Lifting of Suspension Orders |
19 |
(e) Notices
of Certain Events |
19 |
(f) Remediation
of Material Disclosure Defects |
20 |
(g) Listing
of Registrable Securities |
20 |
(h) Provision
of Copies of the Prospectus |
20 |
(i) Holders
Cannot Be Named as Underwriters Without Consent |
20 |
(j) Due
Diligence Matters |
21 |
(k) Earnings
Statement |
21 |
(l) Settlement
of Transfers and De-Legending |
21 |
(m) Certain
Covenants Relating to Underwritten Offerings |
21 |
Section
8. Expenses |
21 |
Section
9. Accrual of Additional Interest During Registration Default Events |
22 |
(a) Generally |
22 |
(b) No
Accrual of Registration Default Fee During any Blackout Period, Etc |
22 |
(c) Accrual
and Payment of Additional Interest |
22 |
Section
10. Certain Agreements and Representations of the Holders |
22 |
(a) Provision
of Information |
22 |
(b) Use
of Offering Materials |
22 |
(c) Covenants
Relating to Blackout Periods |
23 |
Section
11. Indemnification and Contribution |
23 |
(a) Indemnification
by the Borrower |
23 |
(b) Indemnification
by the Holders |
23 |
(c) Indemnification
Procedures |
23 |
(d) Contribution
Where Indemnification Not Available |
25 |
(e) Remedies
Not Exclusive |
25 |
Section
12. Termination of Registration Rights |
26 |
(a) General
Resale Registration Statement |
26 |
(b) Demand
Underwriting Registration Rights |
26 |
(c) Piggyback
Registration Rights |
26 |
Section
13. Subsequent Holders |
26 |
Section
14. Miscellaneous |
26 |
(a) Notices |
26 |
(b) Amendments
and Waivers |
27 |
(c) Third
Party Beneficiaries |
28 |
(d) Governing
Law; Waiver of Jury Trial. |
28 |
(e) Arbitration |
28 |
(f) No
Adverse Interpretation of Other Agreements. |
29 |
(g) Successors |
29 |
(h) Severability |
29 |
(i) Counterparts |
29 |
(j) Table
of Contents, Headings, Etc |
29 |
(k) Service
of Process |
29 |
(l) Entire
Agreement |
29 |
(m) Specific
Performance |
29 |
Exhibits
Exhibit A: Form
of Notice and Questionnaire |
A-1 |
Second Registration
Rights Agreement
SECOND
REGISTRATION RIGHTS AGREEMENT, dated as of October 26, 2023, to be effective as of the Closing Date (as defined below), between Centogene
N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (the “Borrower”),
and the Lender signatory hereto.
WHEREAS,
the execution and delivery of this Agreement is a condition to the closing of the transactions contemplated by the Loan Agreement (as
defined in Section 1).
THEREFORE,
the Borrower agrees as follows for the benefit of the Lender and the Holders (as defined in Section 1):
Section
1.
Definitions.
“Additional
Interest” means any fee payable by the Borrower pursuant to Section 9(c).
“Additional
Interest Rate” means a rate per annum equal to one quarter of one percent (0.25%) for the first ninety (90) days on which Additional
Interest accrues and, thereafter, at a rate per annum equal to one half of one percent (0.50%).
“Affiliate”
has the meaning set forth in Rule 144.
“Agreement”
means this Second Registration Rights Agreement, as amended or supplemented from time to time.
“As-Converted
Registrable Security Ownership Percentage” means, with respect to any Holder(s) as of any time, a fraction (a) whose numerator
is the aggregate number of Registrable Securities owned, or issuable upon conversion of the Loan, held by such Holder(s) as of such time;
and (b) whose denominator is the aggregate number of Registrable Securities that are then outstanding or are issuable upon conversion
of the Loan then outstanding.
“Blackout
Commencement Notice” has the meaning set forth in Section 6(a)(i).
“Blackout
Period” has the meaning set forth in Section 6(a)(v).
“Blackout
Termination Notice” has the meaning set forth in Section 6(a)(v).
“Borrower”
means Centogene N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands.
“Borrower
Indemnified Person” mean each of the following Persons: (a) the Borrower; (b) any Affiliate of the Borrower; (c) any partner,
director, officer, member, shareholder, employee, advisor or other representative of the Borrower or its Affiliates; (d) each Person,
if any, who controls the Borrower within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act; and (e) each
successor of the foregoing Persons.
“Borrower
Registration Expenses” means all fees and expenses incurred by the Borrower in connection with its obligations pursuant to
Section 3, Section 4, Section 5 or Section 7 (regardless of whether any Registration Statement is filed or
becomes effective under the Securities Act or whether any Demand Underwritten Offering or Piggyback Underwritten Offering is consummated),
including the following, to the extent applicable: (a) registration, qualification or filing fees of the SEC, FINRA or state securities
or “blue sky” regulatory agencies; (b) fees incurred in connection with the listing, or the maintaining of any listing, of
any Registrable Securities on any national securities exchange or inter-dealer quotation system; (c) the fees and disbursements of counsel
for the Borrower or of any independent accounting firm for the Borrower; (d) the reasonable fees and out-of-pocket expenses of a single
counsel for the Lender in connection the review of the General Registration Statement Documents contemplated by Section 7(b);
and (e) the reasonable fees and out-of-pocket expenses, of a single Designated Holder Counsel incurred in connection with any Demand
Underwritten Offering, or a single Designated Holder Counsel incurred in connection with any Piggyback Underwritten Offering; provided,
however, that Borrower Registration Expenses will not include (i) any fees, expenses or disbursements of any counsel for any Holder
or for the Lender, except fees and expenses of any such counsel that constitute Borrower Registration Expenses pursuant to clause
(d) or (e) above; or (ii) any underwriting, brokerage or similar fees or discounts or selling commissions, or any share transfer
taxes (or any other taxes borne by any Holder), incurred in connection with the sale or other transfer of any Registrable Securities.
“Business
Day” means any day other than a Saturday, Sunday or any other day on which banking institutions in New York City, United States,
Riyadh, Saudi Arabia or Frankfurt am Main, Germany are authorized or required by Law or executive order to close or be closed.
“Closing
Date” has the meaning set forth in the Terms and Conditions.
“Common
Shares” means the common shares, par value €0.12 per share, of the Borrower.
“Common
Shares Change Event” has the meaning set forth in the Terms and Conditions.
“Demand
Registration Notice” has the meaning set forth in Section 4(a).
“Demand
Registration Statement” means each registration statement under the Securities Act that is designated by the Borrower for the
registration, under the Securities Act, of any Demand Underwritten Offering pursuant to Section 4. For the avoidance of doubt,
the Demand Registration Statement may, at the Borrower’s election, be the General Resale Registration Statement.
“Demand
Underwriting Registration Statement Documents” means any Demand Registration Statement, all pre- and post-effective amendments
thereto, the related prospectus (including any preliminary prospectus), all supplements to such prospectus (including any preliminary
prospectus supplements), the documents incorporated by reference in any of the foregoing and each related “issuer free writing
prospectus” (as defined in Rule 433 under the
Securities Act).
“Demand
Underwritten Offering” has the meaning set forth in Section 4(a).
“Demand
Underwritten Offering Majority Holders” has the meaning set forth in Section 4(d)(i).
“Demanding
Notice Holders” has the meaning set forth in Section 4(a).
“Depositary”
means The Depository Trust, Borrower or any other entity acting as securities depositary for any of the Registrable Securities.
“Designated
Holder Counsel” has the following meaning: (a) with respect to the General Resale Registration Statement, a single counsel
that is designated and appointed by one or more Notice Holders whose aggregate As-Converted Registrable Securities Ownership Percentage
exceeds fifty percent (50%) (with written notice of such designation and appointment to the Borrower by such Notice Holders), to serve
as counsel for all Notice Holders in respect of the General Resale Registration Statement and (b) with respect to any Demand Underwritten
Offering, a single counsel that is designated and appointed by one or more Notice Holders owning a majority of the Registrable Securities
to be sold pursuant to such Demand Underwritten Offering (with written notice thereof to the Borrower by such Notice Holders), to serve
as counsel for such Notice Holders in respect of such Demand Underwritten Offering; and (c) with respect to any Piggyback Underwritten
Offering, a single counsel that is designated and appointed by one or more Notice Holders owning a majority of the Registrable Securities
to be sold pursuant to such Piggyback Underwritten Offering (with written notice thereof to the Borrower by such Notice Holders), to
serve as counsel for such Notice Holders in respect of such Piggyback Underwritten Offering.
“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations of the SEC thereunder.
“FINRA”
means the Financial Industry Regulatory Authority, Inc. or any successor organization performing similar functions.
“Form
F-1” means Form F-1 under the Securities Act, or any successor form thereto.
“Form
F-3” means Form F-3 under the Securities Act, or any successor form thereto.
“Fundamental
Change” has the meaning set forth in the Terms and Conditions.
“General
Resale Registration Statement” means each registration statement under the Securities Act that is filed pursuant to Section
3 for the purposes set forth therein.
“General
Resale Registration Statement Documents” means any General Resale Registration Statement, all pre- and post-effective amendments
thereto, the related prospectus (including any preliminary prospectus), all supplements to such prospectus (including any
preliminary prospectus
supplements), the documents incorporated by reference in any of the foregoing and each related “issuer free writing prospectus”
(as defined in Rule 433 under the Securities Act).
“General
Resale Registration Statement Effectiveness Deadline Date” means the date
that is sixty (60)
days after the Closing Date.
“General
Resale Registration Statement Effectiveness Period” means the period that (a) begins on, and includes, the earlier of (i) the
General Resale Registration Statement Effectiveness Deadline Date; and (ii) the first date the General Resale Registration Statement
is effective under the Securities Act; and (b) ends on, and includes, the first date when no Registrable Securities are outstanding.
“General
Shelf Registration Statement” has the meaning set forth in Section 5(e).
“Holder”
means, subject to Section 13, any Person that beneficially owns any Registrable Securities. For these purposes, a Person will
be deemed to beneficially own any Registrable Securities issuable upon conversion of any other securities beneficially owned by such
person.
“Holder
Indemnified Person” mean each of the following Persons: (a) any Holder; (b) any Affiliate of any Holder; (c) any partner, director,
officer, member, shareholder, employee, advisor or other representative of any Holder or its Affiliates; (d) each Person, if any, who
controls any Holder within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act; and (e) each successor
of the foregoing Persons.
“Holder
Information” means, with respect to any Holder, any information furnished in writing by or on behalf of such Holder to the
Borrower expressly for use in any Registration Statement Document (including information in any Notice and Questionnaire delivered by
such Holder to the Borrower).
“Indemnified
Person” means any Borrower Indemnified Person or Holder Indemnified Person.
“Indemnifying
Party” has the meaning set forth in Section 11(c)(i).
“Initial
Notice and Questionnaire Deadline Date” means the date that is ten (10) calendar days before the first date that the relevant
General Resale Registration Statement becomes effective under the Securities Act.
“JAMS”
has the meaning set forth in Section 14(e).
“JAMS
Rules” has the meaning set forth in Section 14(e).
“Lender”
means that certain Lender party to that certain Loan Agreement and its Permitted Transferees (as defined in the Loan Agreement).
“Loan
Agreement” means that certain loan agreement, dated October 26, 2023 between the Borrower, as borrower thereunder and the Lender
party thereto.
“Loss”
means any loss, damage, expense, liability or claim (including reasonable costs of investigating or defending, and reasonable attorney’s
fees and disbursements in connection with, the same).
“Managing
Underwriters” means, with respect to any Demand Underwritten Offering or Piggyback Underwritten Offering, one or more registered
broker-dealers that are designated in accordance with this Agreement to administer such offering.
“Material
Disclosure Defect” has the following meaning with respect to any document: (a) if such document is of the type as to which
the provisions of Section 11 of the Securities Act are applicable, that such document contains an untrue statement of a material fact
or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading; and (b) in
all other cases, that such document includes an untrue statement of a material fact or omits to state a material fact necessary in order
to make the statements therein, in the light of the circumstances under which they were made, not misleading.
“Maximum
Successful Underwritten Offering Size” means, with respect to any Demand Underwritten Offering or Piggyback Underwritten Offering,
the maximum number of securities that may be sold in such offering without adversely affecting the success of such offering, as advised
by the Managing Underwriters for such offering to the Borrower and the applicable Demand Underwritten Offering Majority Holders.
“Non-Holder
Securities” means any securities of the Borrower, or of any Person other than any Holder, to be included in any Piggyback Underwritten
Offering.
“Notice
and Questionnaire” means a duly completed and executed Notice and Questionnaire substantially in the form set forth in Exhibit
A.
“Notice
Holder” means, subject to Section 13, a Holder that has delivered a Notice and Questionnaire to the Borrower.
“Offering
Launch Time” means, with respect to a Demand Underwritten Offering or Piggyback Underwritten Offering, the earliest of (a)
the first date a preliminary prospectus (or prospectus supplement) for such offering is filed with the SEC; (b) the first date such offering
is publicly announced; and (c) the date a definitive agreement is entered into with the Managing Underwriters respect to the such offering.
“Person”
or “person” means any individual, corporation, partnership, limited liability company, joint venture, association,
joint-stock company, trust, unincorporated organization or government or other agency or political subdivision thereof. Any division
or series of a limited liability company, limited partnership or trust will constitute a separate “person” under this Agreement.
“Piggyback
Registration Statement” means each registration statement under the Securities Act that registers any Piggyback Underwritten
Offering that includes any Registrable Securities pursuant to Section 5.
“Piggyback
Registration Statement Documents” means any Piggyback Registration Statement, all pre- and post-effective amendments thereto,
the related prospectus (including any preliminary prospectus), all supplements to such prospectus (including any preliminary prospectus
supplements), the documents incorporated by reference in any of the foregoing and each related “issuer free writing prospectus”
(as defined in Rule 433 under the Securities Act).
“Piggyback
Right” has the meaning set forth in Section 5(a)(ii).
“Piggyback
Underwritten Offering” means a firmly underwritten public offering of the Common Shares that are registered under the Securities
Act and pursuant to which the Borrower or other selling shareholders sell Common Shares to one or more underwriters for reoffering to
the public for cash; provided, however, that the following will not constitute a Piggyback Underwritten Offering: (a) any
Demand Underwritten Offering; and (b) any “at-the-market” offering pursuant to which Common Shares are sold from time to
time into an existing market at prices then prevailing.
“Piggyback
Underwritten Offering Notice” has the meaning set forth in Section 5(a)(i).
“Piggyback
Underwritten Offering Notice Deadline Date” means, with respect to any Piggyback Underwritten Offering, the fourth (4th) Business
Days before the date of the Offering Launch Time for such Piggyback Underwritten Offering; provided, however, that if a
new registration statement that is not an “automatic registration statement” (as defined in Rule 405 under the Securities
Act) will be filed for such Piggyback Underwritten Offering, then the Piggyback Underwritten Offering Notice Deadline Date will instead
be the fifth (5th) Business Days before the date such registration statement is initially filed with the SEC.
“Proceeding”
has the meaning set forth in Section 11(c)(i).
“Registrable
Securities” means:
(a) the
Common Shares or other securities issued or issuable (including following a Common Shares Change Event) upon conversion of the Loan;
and
(b) any
securities issued, distributed or otherwise delivered with respect to any security referred to in clause (a) above upon any share
dividend, combination or split or other similar event or in connection with a Common Shares Change Event;
provided,
however, that a security described in clause (a) or (b) above will cease to be a Registrable Security when such
security ceases to be outstanding.
“Registration
Default Event” means any event set forth in Section 9 that gives rise to
the accrual of
any Additional Interest pursuant to Section 9.
“Registration
Statement” means any General Resale Registration Statement, Demand Underwriting Registration Statement or Piggyback Registration
Statement.
“Registration
Statement Documents” means any General Resale Registration Statement Documents, Demand Underwriting Registration Statement
Documents or Piggyback Registration Statement Documents.
“Relevant
Stock Exchange” means the principal securities exchange on which the Common Shares are listed; provided, however,
that if the Common Shares are listed on a U.S. national securities exchange, then the Relevant Stock Exchange will be such U.S. national
securities exchange. For the avoidance of doubt, the Relevant Stock Exchange as of the Closing Date is The Nasdaq Stock Market LLC.
“Rule
144” means Rule 144 under the Securities Act (or any successor rule thereto).
“Rule
415” means Rule under the Securities Act (or any successor rule thereto).
“SEC”
means the U.S. Securities and Exchange Commission.
“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations of the SEC thereunder.
“Specified
Courts” has the meaning set forth in Section 14(e).
“Take-Private
Transaction” has the meaning set forth in Section 12(a).
“Terms
and Conditions” means the Terms and Conditions establishing the rights and obligations of the Borrower under, and the terms
and conditions of, the Loan, attached as Exhibit A to the Loan Agreement.
“Un-Marketed
Block Trade” means a Demand Underwritten Offering in connection
with which no director,
officer or other employee of the Borrower participates in any live
or pre-recorded
“roadshow” or similar presentation
Section
2.
Rules of Construction. For purposes of this Agreement:
(a) “or”
is not exclusive;
(b) “including”
means “including without limitation”;
(c) “will”
expresses a command;
(d) a
merger involving, or a transfer of assets by, a limited liability company, limited
partnership or
trust will be deemed to include any division of or by, or an allocation of assets to a series of, such limited liability company, limited
partnership or trust, or any unwinding of any such division or allocation;
(e) words
in the singular include the plural and in the plural include the singular, unless the context requires otherwise;
(f) “herein,”
“hereof” and other words of similar import refer to this Agreement as a whole and not to any particular Section or other
subdivision of this Agreement, unless the context requires otherwise;
(g) references
to currency mean the lawful currency of the United States of America, unless the context requires otherwise; and
(h) the
exhibits, schedules and other attachments to this Agreement are deemed to form part of this Agreement.
Section
3.
General Resale Registration Statement.
(a)
Filing and Effectiveness of General Resale Registration Statement. Subject to Section 6, the Borrower will (i)
prepare and file a General Resale Registration Statement with the SEC; and (ii) use its commercially reasonable efforts to cause such
General Resale Registration Statement to (x) become effective under the Securities Act as soon as reasonably practicable, but will cause
the same to occur in any event no later than the General Resale Registration Statement Effectiveness Deadline Date; and (y) remain continuously
effective, and usable for the resale or other transfer of Registrable Securities, under the Securities Act throughout the General Resale
Registration Statement Effectiveness Period.
(b)
Contents of and Requirements for General Resale Registration Statement. The Borrower will cause the General Resale
Registration Statement to satisfy the following requirements:
(i)
Registration for Continuous Resale by Holders Under Rule 415. The General Resale Registration Statement will register,
under the Securities Act, the offer and resale, from time to time on a continuous basis under Rule 415, of Registrable Securities by
the Holders thereof as provided in Sections 3(b)(ii) and 3(c).
(ii)
Selling Securityholder Information. When it first becomes effective under the Securities Act, the General Resale Registration
Statement will cover resales of Registrable Securities of Notice Holders identified in all Notice and Questionnaires delivered to the
Borrower on or before the Initial Notice and Questionnaire Deadline Date. Thereafter, the General Resale Registration Statement will
cover resales of Registrable Securities of Notice Holders as provided in Section 3(c). Each Holder as to which any General Resale
Registration Statement is being effected agrees to furnish to the Borrower all information with respect to such Holder necessary to make
the information previously furnished to the Borrower by such Holder not materially misleading. No Holder shall be permitted to include
any of its Registrable Securities in
any
General Resale Registration Statement pursuant to this Agreement unless and until it complies with the terms of this Section 3(b)(ii).
(iii)
Plan of Distribution. The General Resale Registration Statement will provide for a plan of distribution in customary form
(and reasonably satisfactory to the Holders) for resale registration statements of the type contemplated by this Agreement, including
coverage for market transactions on a national securities exchange, privately negotiated transactions and transactions through broker-dealers
acting as agent or principal. In addition, if the rules under the Securities Act then so permit, such plan of distribution will permit
underwritten offerings (including “block” trades) through one or more registered broker-dealers acting as underwriters to
be effected pursuant to one or more prospectus supplements that identify such underwriters (in addition to any other information that
may then be required pursuant to the Securities Act); provided, however, that the Borrower will be under no obligation
to effect any such underwritten offering pursuant to the General Resale Registration Statement except pursuant to Section 4.
(iv)
Form F-3. If the resales contemplated by the General Resale Registration Statement are then eligible to be registered by
the Borrower on Form F-3, then the General Resale Registration Statement will be on such Form F-3. If the Borrower is ineligible to use
Form F-3, then the General Resale Registration Statement will be on Form F-1 or another form reasonably acceptable to the Holders. If
Form F-3 is not available for registration of the Registrable Securities hereunder, the Borrower shall undertake to register the resale
of the Registrable Securities on Form S-3 as soon as such form is available, provided that the Borrower shall maintain the effectiveness
of all Registration Statements then in effect until such time as a General Resale Registration Statement on Form S-3 covering the resale
of all the Registrable Securities has been declared effective by the SEC and the prospectus contained therein is available for use. If
the General Resale Registration Statement ceases to be effective under the Securities Act for any reason at any time while Registrable
Securities are still outstanding, the Borrower shall use its commercially reasonable efforts to as promptly as is reasonably practicable
cause such General Resale Registration Statement again become effective under the Securities Act, or a new General Resale Registration
Statement to be filed and declared effective.
(c)
Obligation to Make Filings to Name Additional Notice Holders. If any Holder delivers a Notice and Questionnaire to
the Borrower after the Initial Notice and Questionnaire Deadline Date, then, subject to Section 6 and the other provisions of
this Section 3(c), the Borrower will make such filing(s) with the SEC (including, if applicable, (w) a post-effective amendment,
(x) a prospectus supplement, (y) any document that will be incorporated by reference in the General Resale Registration Statement upon
its filing or (z) a new General Resale Registration Statement, provided that the Borrower will effect such filing by means of
a prospectus supplement or a document referred to in the preceding clause (y) instead of a post-effective amendment or a new Resale
Registration Statement, if reasonably practicable and then permitted by the rules of the SEC) so as to enable such Holder to sell or
otherwise transfer such Holder’s Registrable Securities identified in such Notice and Questionnaire pursuant to the applicable
General Resale Registration Statement and the related prospectus and, if applicable, prospectus supplement in accordance with the plan
of distribution set forth therein. Subject to the
next sentence,
the Borrower will make such filing(s) as follows: (i) within sixty (60) calendar days after the date of such delivery (or, if such Notice
and Questionnaire is delivered before the initial effective date of the General Resale Registration Statement or during a Blackout Period,
such effective date or the last day of such Blackout Period, respectively), if a new General Resale Registration Statement is required
(and the Borrower will use commercially reasonable efforts to cause such new General Resale Registration Statement to become effective
under the Securities Act as soon as reasonably practicable); and (ii) in all other cases, within fifteen (15) calendar days after the
date of such delivery (or, if such Notice and Questionnaire is delivered before the initial effective date of the General Resale Registration
Statement or during a Blackout Period, such effective date or the last day of such Blackout Period, respectively). Notwithstanding anything
to the contrary in this Section 3(c), the Borrower will in no event be required pursuant to this Section 3(c) to file more
than one (1) new General Resale Registration Statement within any twelve (12) month period or more than one (1) other filing in any six
(6) month period.
(d)
Filing of New General Resale Registration Statement; Designation of Existing Registration Statement. To the extent
the Borrower deems doing so to be desirable or necessary to satisfy its obligations under this Agreement or to comply with applicable
law (including, if applicable, to comply with Rule 415(a)(5)), the Borrower may file one or more new General Resale Registration Statements
or designate an existing registration statement of the Borrower to constitute a General Resale Registration Statement for purposes of
this Agreement, provided that each such new General Resale Registration Statement or existing registration statement satisfies
the requirements of this Agreement. Each reference in this Agreement to the General Resale Registration Statement will, if applicable,
be deemed to include each such new General Resale Registration Statement or existing registration statement, if any, mutatis mutandis.
In addition, the first date any such existing registration statement is amended or supplemented to permit the offer and resale of Registrable
Securities in the manner contemplated by this Agreement will be deemed, for purposes of Sections 7(b) and 7(e) and any
related definitions, to be the initial filing date of such existing registration statement, and the first date such amended or supplemented
existing registration statement is effective under the Securities Act and permits such the offers and resales will be deemed, for purposes
of Sections 3(b)(ii), 3(c) and 7(e) and any related definitions, to be the initial effective date of such existing
registration statement.
(e)
Where SEC Rules Do Not Require Naming Selling Securityholders. Notwithstanding anything to the contrary in this Section
3, if the applicable rules under the Securities Act, or interpretations thereof published by the staff of the SEC, are amended so
as to permit Holders to resell their Registrable Securities pursuant to the General Resale Registration Statement without being named
as a selling securityholder therein or in any related prospectus or prospectus supplement, then the Borrower may, at its election, amend
any applicable General Resale Registration Statement Documents to identify the Holders generically in accordance with such rules and
interpretations, in which event the Borrower will no longer have any obligation thereafter make any filings pursuant to Section 3(c)
to the extent such filings are not necessary to permit any Holder to sell its Registrable Securities pursuant to the General Resale
Registration Statement.
Section
4.
Demand Underwriting Registration Rights.
(a)
Right to Demand Underwriting Registrations. Subject to the other provisions of
this Section
4, Holders will have the right, exercisable by written notice satisfying the requirements of Section 4(b) (a “Demand
Registration Notice”) to the Borrower by any one or more Notice Holders whose aggregate As-Converted Registrable Security Ownership
Percentage exceeds twenty-five percent (25%) (such Notice Holders, the “Demanding Notice Holders”), to require the
Borrower to register, under the Securities Act, a firmly underwritten public offering (a “Demand Underwritten Offering”)
of Registrable Securities in accordance with this Section 4; provided, however, that:
(i)
no Demand Registration Notice may be delivered, or will be effective, unless, at the time it is delivered, the Borrower has an
effective registration statement on Form F-3 (or, if Form F-3 is not available, any other form described in Section 3(b)(iv))
on file with the SEC (including, if applicable, the General Resale Registration Statement) that is available and permitted to be used
to register the applicable Demand Underwritten Offering by means of one or more prospectus supplements to such registration statement;
(ii)
no Demand Registration Notice may be delivered, or will be effective, if:
(1) a
prior Demand Underwritten Offering is pending or in process, and is not completed or withdrawn, at the time such Demand Registration
Notice is delivered;
(2) either
(A) if such Demand Registration Notice requests a Demand Underwritten Offering that is not an Un-Marketed Block Trade, the aggregate
number of prior Demand Underwritten Offerings (other than Un-Marketed Block Trades) that have been completed or withdrawn is two (2)
or more; or (B) if such Demand Registration Notice requests a Demand Underwritten Offering that is an Un-Marketed Block Trade, the aggregate
number of prior Demand Underwritten Offerings that are Un-Marketed Block Trades and have been completed or withdrawn is two (2) or more;
provided, however, that solely for purposes of this clause (2), a Demand Underwritten Offering will not count as being
“withdrawn” unless it is withdrawn after its Offering Launch Time;
(3) it is delivered during a Blackout Period; or
(4) the aggregate market value of the Registrable Securities of such Notice Holder(s) to be included in the requested Demand Underwritten
Offering is less than ten million dollars ($10,000,000) or such lesser amount that constitutes all of the Demanding Notice Holder’s
Registrable Securities.
(b)
Contents of Demand Registration Notice. Each Demand Registration Notice sent by any Demanding Notice Holder(s) must
state the following:
(i)
the name of, and contact information for, each such Demanding Notice Holder(s) and the number of the Registrable Securities that
are outstanding and were issued upon conversion of the Loan that was issued pursuant to the Loan Agreement;
(ii)
the desired date of the Offering Launch Time for the requested Demand
Underwritten
Offering, which desired date cannot (without the Borrower’s consent, which will not be unreasonably withheld or delayed) be earlier
than ten (10) Business Days after the date such Demand Registration Notice is delivered to the Borrower;
(iii)
the number of Registrable Securities that are proposed to be sold by each such Demanding Notice Holder; and
(iv)
if the intended method of disposition is an Un-Marketed Block Trade.
(c)
Participation by Persons Other Than the Demanding Notice Holder(s). If the Borrower receives a Demand Registration
Notice sent by one or more Demanding Notice Holders, then:
(i)
the Borrower will, within three (3) (or, in the case of an Un-Marketed Block Trade, two (2)) Business Days, send a copy of such
Demand Registration Notice to each Notice Holder other than such Demanding Notice Holders; and
(ii)
subject to Section 4(f), the Borrower will use its commercially reasonable efforts to include, in the related Demand Underwritten
Offering, (1) Registrable Securities of any such Notice Holder that has requested such Registrable Securities to be included in such
Demand Underwritten Offering pursuant to a joinder notice that complies with the next sentence and (2) the securities of any other person
entitled to request the inclusion of Common Shares in such Demand Underwritten Offering.
To include any
of its Registrable Securities in such Demand Underwritten Offering, a Notice Holder must deliver to the Borrower, no later than the fifth
(5th) Business Day (or, in the case of an Un-Marketed Block Trade, the Business Day after the date on which Borrower sent a copy of such
Demand Registration Notice pursuant to subsection (i) above, a written instrument, executed by such Notice Holder, joining in
such Demand Registration Notice, which instrument contains the information set forth in Section 4(b)(iii) with respect to such
Notice Holder.
(d)
Certain Procedures Relating to Demand Underwritten Offerings.
(i)
Obligations and Rights of the Borrower. Subject to the other terms of this Agreement, upon its receipt of a Demand Registration
Notice, the Borrower will (1) designate a Demand Registration Statement, in accordance with the definition of such term and this Section
4, for the related Demand Underwritten Offering; and (2) use commercially reasonable efforts to effect such Demand Underwritten Offering
in accordance with the requests set forth in such Demand Registration Notice or the requests of the Notice Holders whose Registrable
Securities are included in such Demand Underwritten Offering (the “Demand Underwritten Offering Majority Holders”),
and cooperate in good faith with such Notice Holders in connection therewith. Notwithstanding anything to the contrary in this Agreement,
the Borrower will not be obligated to effect, or take any actions in respect of, any Demand Underwritten Offering (i) during a Blackout
Period, (ii) after the Borrower has already effected two (2) Demand Underwritten Offerings pursuant to this Agreement, (iii) after the
Borrower has already effected two (2) Un-Marketed Block Trades or (iv) at any time when the securities
proposed
to be sold pursuant to such Demand Underwritten Offering are subject to any lock-up agreement (including pursuant to a prior Demand Underwritten
Offering) that has not been waived or released. The Borrower will be entitled to rely on the authority of the Demand Underwritten Offering
Majority Holders of any Demand Underwritten Offering to act on behalf of all Holders that have requested any securities to be included
in or at any time when the securities proposed to be sold pursuant to such Demand Underwritten Offering.
(ii)
Designation of the Underwriting Syndicate. The Managing Underwriters, and any other underwriter, for any Demand Underwritten
Offering will be selected by the applicable Demand Underwritten Offering Majority Holders with the approval of the Borrower (which will
not be unreasonably withheld or delayed).
(iii)
Authority of the Demand Underwriting Offering Majority Holders to Control Offering Procedures, Timing and Related Matters.
Notwithstanding anything to the contrary in this Agreement, the applicable Demand Underwritten Majority Holders will have the following
rights with respect to each Demand Underwritten Offering:
(1) in consultation with the Managing Underwriters for such Demand Underwritten Offering, to determine the Offering Launch Time and
timing for such Demand Underwritten Offering, which date must comply with the limitations set forth in Section 4(b)(ii);
(2) to
determine the structure of the offering, provided such structure is reasonable and customary;
(3) to negotiate any related underwriting agreement and it terms, including the amount of securities to be sold by the applicable
Holders pursuant thereto and the offering price of, and underwriting discount for, such securities; provided, however,
that the Borrower will have the right to negotiate in good faith all of their respective representations, warranties and covenants, and
indemnification and contribution obligations, set forth in any such underwriting agreement.
(e)
Conditions Precedent to Inclusion of a Notice Holder’s Registrable Securities. Notwithstanding anything to the
contrary in this Section 4, the right of any Notice Holder to include any of its Registrable Securities in any Demand Underwritten
Offering will be subject to the following conditions:
(i)
the execution and delivery, by such Notice Holder or it is duly authorized representative or power of attorney, of any related
underwriting agreement and such other agreements or instruments (including customary “lock-up” agreements, custody agreements
and powers of attorney), if any, as may be reasonably requested by the Managing Underwriters for such Demand Underwritten Offering (and,
if reasonably required, medallion-guaranteed); and
(ii)
the provision, by such Notice Holder no later than the Business Day immediately after the request therefor, of any information
reasonably requested by the
Borrower
or such Managing Underwriters in connection with such Demand Underwritten Offering.
(f)
Priority of Securities in Demand Underwritten Offerings. If the total number of securities requested to be included
in a Demand Underwritten Offering pursuant to this Section 4 exceeds the Maximum Successful Underwritten Offering Size for such
Demand Underwritten Offering, then:
(i)
the number of securities to be included in such Demand Underwritten Offering will be reduced to an amount that does not exceed
such Maximum Successful Underwritten Offering Size; and
(ii)
to effect such reduction,
(1) the
number of Non-Holder Securities included in such Demand Underwritten Offering will be reduced, provided that Borrower shall have
the right to allocate such reduction of the Non-Holder Securities requested to be included in such Demand Underwritten Offering in its
sole discretion; and
(2) if, after excluding all Non-Holder Securities from such Demand Underwritten Offering, the number of Registrable Securities of
Notice Holders that have duly requested such Registrable Securities to be included in such Demand Underwritten Offering in accordance
with this Section 4 exceeds such Maximum Successful Underwritten Offering Size, then number of Registrable Securities to be included
in such Demand Underwritten Offering will be allocated pro rata based on the total number of Registrable Securities so requested by each
such Notice Holder to be included in such Demand Underwritten Offering.
(g)
Covenant Regarding Piggyback Rights with Respect to Demand Underwritten Offering. The Borrower will not grant any Person
(other than a Holder or Notice Holder) the right to include any securities of such Person in any Demand Underwritten Offering.
Section
5.
Piggyback Registration Rights.
(a)
Notice of Piggyback Underwritten Offering and Right to Participate Therein. Subject to the other provisions of this
Section 5, if the Borrower proposes to engage in a Piggyback Underwritten Offering, then:
(i)
no later than the Piggyback Underwritten Offering Notice Deadline Date for such Piggyback Underwritten Offering, the Borrower
will send to each Notice Holder written notice (the “Piggyback Underwritten Offering Notice”) of such Piggyback Underwritten
Offering setting forth the anticipated Offering Launch Time for the related Piggyback Underwritten Offering and the deadline (determined
as provided in subsection (ii) below) by which the related Piggyback Right may be exercised; and
(ii)
each Notice Holder will have the right (the “Piggyback Right”) to include all or any portion of its Registrable
Securities in such Piggyback Underwritten Offering,
on
the same financial terms and conditions as apply to the Borrower, which right is exercisable by delivering, no later than ten (10) Business
Days after the date the Borrower sends such Piggyback Underwritten Offering Notice pursuant to subsection (i) above, written notice
to the Borrower setting forth (1) the name of, and contact information for, such Notice Holder; and (2) the number of such Notice Holder’s
Registrable Securities that such Notice Holder requests to be included in such Piggyback Underwritten Offering.
(b)
Certain Procedures Relating to Piggyback Underwritten Offerings.
(i)
Obligations of the Borrower. Subject to the other terms of this Agreement, upon exercise of any Piggyback Rights to include
any Notice Holder’s Registrable Securities in a Piggyback Underwritten Offering, the Borrower will use commercially reasonable
efforts to include such Registrable Securities in such Piggyback Underwritten Offering and will cooperate in good faith with such Notice
Holder in connection therewith.
(ii)
Designation of the Underwriting Syndicate. The Managing Underwriters, and any other underwriter, for any Piggyback Underwritten
Offering will be selected by the Borrower in its sole discretion provided, however, that the Managing Underwriters must
be investment banking firms nationally recognized in the United States.
(iii)
Right of the Borrower to Control Offering Procedures, Timing and Related Matters. Notwithstanding anything to the contrary
in this Agreement, the Borrower will have the following rights with respect to each Piggyback Underwritten Offering:
(1) to determine the Offering Launch Time and timing for such Piggyback Underwritten Offering;
(2)
to determine the structure of the offering, provided such structure is reasonable and customary;
(3) to negotiate any related underwriting agreement and it terms, including the amount of securities to be sold by the Borrower or
persons other than Notice Holders pursuant thereto and the offering price of, and underwriting discount for, such securities; provided,
however, that the Notice Holders whose Registrable Securities are included in such Piggyback Underwritten Offering will have the
right negotiate in good faith all of their respective representations, warranties and covenants, and indemnification and contribution
obligations, set forth in any such underwriting agreement; and
(4) to terminate such Piggyback Underwritten Offering in its sole discretion, provided that the Borrower will provide notice of any
such termination to all Notice Holders whose Registrable Securities were to be included in such Piggyback Underwritten Offering.
(c)
Conditions Precedent to Inclusion of a Notice Holder’s Registrable Securities.
Notwithstanding
anything to the contrary in this Section 5, the right of any Notice Holder to include any of its Registrable Securities in any
Piggyback Underwritten Offering upon exercise of the Piggyback Rights therefor will be subject to the followings conditions:
(i)
the execution and delivery, by such Notice Holder or it is duly authorized representative or power of attorney, of any related
underwriting agreement and such other agreements or instruments (including customary “lock-up” agreements, custody agreements
and powers of attorney), if any, as may be reasonably requested by the Managing Underwriters for such Piggyback Underwritten Offering
(and, if reasonably required, medallion-guaranteed); and
(ii)
the provision, by such Notice Holder no later than the Business Day immediately after the request therefor, of any information
reasonably requested by the Borrower or such Managing Underwriters in connection with such Piggyback Underwritten Offering.
(d)
Priority of Securities in Piggyback Underwritten Offerings. If the total number of securities proposed to be included
in a Piggyback Underwritten Offering pursuant to this Section 5 exceeds the Maximum Successful Underwritten Offering Size for
such Piggyback Underwritten Offering, then:
(i)
the number of securities to be included in such Piggyback Underwritten Offering will be reduced to an amount that does not exceed
such Maximum Successful Underwritten Offering Size; and
(ii)
to effect such reduction,
(1) (A) the number of Registrable Securities of Notice Holders that have duly requested such Registrable Securities to be included
in such Piggyback Underwritten Offering in accordance with this Section 5 will be reduced; and (B) the amount of such Registrable
Securities, if any, that will be included in such Piggyback Underwritten Offering after giving effect to such reduction pursuant to clause
(A) will be allocated pro rata based on the total number of Registrable Securities so requested by each such Notice Holder to be
included in such Piggyback Underwritten Offering; and
(2)
if, after excluding all Registrable Securities from such Piggyback Underwritten Offering, the number of securities to be included
in such Piggyback Underwritten Offering exceeds such Maximum Successful Underwritten Offering Size, then the number of the number of
Non-Holder Securities included in such Piggyback Underwritten Offering will be reduced.
(e)
Filing of General Shelf Registration Statements. If, at
any time when any Piggyback Rights then exist and have not lapsed in accordance with Section 12, the Borrower files a registration
statement under the Securities Act on Form S-3 (or, if Form S-3 is not available, any other form described in Section 3(b)(iv))
or other offering statement (a “General Shelf Registration Statement”) relating to an offering for the Borrower’s own
account (or the account of others) that contemplates registering any of the Borrower’s equity or equity-linked
securities
or their then equivalents relating to equity or equity-linked securities to be issued solely in connection with any acquisition of any
entity or business (or a business combination subject to Rule 145 under the Securities Act) or equity or equity-linked securities issuable
in connection with the Borrower’s share option or other employee benefit plans), or a dividend reinvestment or similar plan or
rights offering, then the Borrower will include, in such General Shelf Registration Statement, such statements or disclosures, if any,
that would be necessary to be included therein at the time of its effectiveness under the Securities Act to permit offers and sales of
Registrable Securities by Notice Holders to be made pursuant to such General Shelf Registration Statement in accordance with this Section
5 if Piggyback Rights with respect thereto were exercised; provided, however, that this Section 5(e) will not apply:
(i)
at any time when the General Resale Registration Statement (or any other registration statement of the Borrower that would then
permit offers and sales of Registrable Securities as described above) is effective under the Securities Act, and a common prospectus
or prospectus supplement is eligible to be used pursuant to Rule 429 under the Securities Act (or any successor rule) with the General
Resale Registration Statement (or such other registration statement) and the General Shelf Registration Statement in manner that would
permit offers and sales of Registrable Securities as described above; or
(ii)
offers and sales of Registrable Securities as described above would be permitted to be made by a prospectus supplement, to the
prospectus included in such General Shelf Registration Statement, filed in accordance with Rule 430B under the Securities Act, without
the need to include any additional statements or disclosures in such General Shelf Registration Statement at the time of its effectiveness.
(f)
Notice of General Shelf Registration Statements and Right to Participate Therein. Subject to the other provisions of
this Section 5, if the Borrower proposes to file a General Shelf Registration Statement, then each Notice Holder will have the
Piggyback Right to include all or any portion of its Registrable Securities in such General Shelf Registration Statement, which right
is exercisable by delivering, no later than ten (10) Business Days after the date the Borrower sends written notice of such General Shelf
Registration Statement, written notice to the Borrower setting forth (1) the name of, and contact information for, such Notice Holder;
and (2) the number of such Notice Holder’s Registrable Securities that such Notice Holder requests to be included in such General
Shelf Registration Statement. The Borrower will use commercially reasonable efforts to include such Registrable Securities in such General
Shelf Registration Statement and will cooperate in good faith with such Notice Holder in connection therewith.
Section
6.
Blackout Periods.
(a)
Generally. Notwithstanding anything to the contrary in this Agreement, but subject to Section 6(b), if there
occurs or exists any pending corporate development, filing with the SEC or any other event, in each case that, in the Borrower’s
reasonable judgment, makes it appropriate to suspend the availability of any Registration Statement or any pending or potential Demand
Underwritten Offering, then:
(i)
the Borrower will send notice (a “Blackout Commencement Notice”) to
each
Notice Holder of such suspension (without setting forth any material non-public information);
(ii)
the Borrower’s obligations under Section 3 or otherwise with respect to the General Resale Registration Statement,
under Section 4 or otherwise with respect to any Demand Registration Notice or under Section 5 with respect to any Piggyback
Underwritten Offering, in each case will be suspended until the related Blackout Period has terminated;
(iii)
upon its receipt of such Blackout Commencement Notice, each Holder agrees to comply with its obligations set forth in Section
10(c);
(iv)
the Borrower shall not engage in any sales of any securities of the Borrower for the duration of the Blackout Period; and
(v)
upon the Borrower’s determination that such suspension is no longer needed or appropriate, the Borrower will send notice
(a “Blackout Termination Notice,” and the period from, and including, the date the Borrower sends such Blackout Commencement
Notice to, and including, the date the Borrower sends such Blackout Termination Notice, a “Blackout Period”) to each
Notice Holder of the termination of such suspension (without setting forth any material non-public information).
(b)
Limitation on Blackout Periods. No single Blackout Period can extend beyond ninety (90) consecutive calendar days,
and the total number calendar days in all Blackout Periods cannot exceed an aggregate of one hundred twenty (120) calendar days (whether
or not consecutive) in any period of twelve (12) full calendar months.
(c)
[Reserved].
Section
7.
Certain Registration and Related Procedures.
(a)
Compliance with Registration Obligations and Securities Act; SEC Staff Comments. Subject to Section 6, the Borrower
will use its commercially reasonable efforts to make such filings with the SEC as may be necessary to comply with its obligations under
Section 3, Section 4 and Section 5 and to cause each Registration Statement to comply with the Securities Act and
other applicable law, including, if applicable, the filing of any Registration Statement Documents to comply with Section 10(a)(3) of
the Securities Act and Rule 3-12 of Regulation S-X under the Securities Act, to amend such Registration Statement to cause the same to
be on a form for which the Borrower and the transactions contemplated thereby are eligible, and to address any comments received from
the staff of the SEC. The Borrower will otherwise use its commercially reasonable efforts to comply with the Securities Act and other
applicable law in the discharge of its obligations under Section 3, Section 4 and Section 5.
(b)
Opportunity for Review. The Borrower will provide the Lender and each Notice Holder with a reasonable opportunity to
comment on draft copies of the initial filing of the General Resale Registration Statement, each pre-effective and post-effective amendment
thereto,
and each related
prospectus supplement, at least five (5) Business Days before the same is filed with the SEC, and the Borrower will use its commercially
reasonable efforts to give effect to the comments timely received by the Borrower from the Lender or such Notice Holders; provided,
however, that no such opportunity to comment will be provided in the case of a prospectus supplement that solely supplements or
amends selling securityholder information and is filed pursuant to Rule 424(b)(7) under the Securities Act (or any successor rule). Each
Notice Holder whose Registrable Securities are to be sold pursuant to a Demand Registration Statement in accordance with Section 4
or a Piggyback Registration Statement in accordance with Section 5 will be afforded the same rights set forth in this Section
7(b) with respect to any prospectus supplement or other Registration Statement Document relating such Registration Statement, which
prospectus supplement or other Registration Statement Document names such Notice Holder.
(c)
Blue Sky Qualification. The Borrower will use its commercially reasonable efforts to register or qualify the offer
and sale of Registrable Securities in the manner contemplated by the General Resale Registration Statement (or any other applicable Registration
Statement, to the extent any are to be sold pursuant thereto in accordance with Section 4 or Section 5, as applicable)
under the securities or “blue sky” laws of those jurisdictions within the United States as the Notice Holders or the Managing
Underwriters, as applicable, may reasonably request in writing and to maintain such qualification, once obtained, during the General
Resale Registration Statement Effectiveness Period (in the case of the General Resale Registration Statement) or until the completion
of the offering contemplated thereby (in the case of any other Registration Statement), the Borrower will use its commercially reasonable
efforts to cooperate with such Notice Holders or the Managing Underwriters, as applicable, in connection with the same, except, in each
case, to the extent such qualification is not required in connection with such offer and sale (including as a result of preemption by
federal law pursuant to Section 18 of the Securities Act (or any successor provision)); provided, however, that the Borrower
will not be required to qualify generally to do business in any jurisdiction where it is not then so qualified.
(d)
Prevention and Lifting of Suspension Orders. The Borrower will use its commercially reasonable efforts to prevent the
issuance (or, if issued, to obtain the withdrawal as promptly as practicable) of any order suspending the effectiveness of the General
Resale Registration Statement (or any other Registration Statement, to the extent any are to be sold pursuant thereto in accordance with
Section 4 or Section 5, as applicable) under the Securities Act or suspending any qualification referred to in Section
7(c).
(e)
Notices of Certain Events. The Borrower will provide notice of the following events to the Lender and to each Notice
Holder as soon as reasonably practicable:
(i) the
filing with the SEC of the General Resale Registration Statement, any pre- or post-effective amendment thereto or any related prospectus,
prospectus supplement or “issuer free writing prospectus” (as defined in Rule 433 under the Securities Act);
(ii) the effectiveness under the Securities Act, of the General Resale Registration Statement or any amendment thereto;
(iii)
the receipt, by the Borrower, of any request by the staff of the SEC or any other governmental authority for any amendment or
supplement to the General Resale Registration Statement;
(iv) the issuance, by the SEC or any other governmental authority, of any stop order suspending the effectiveness of the General Resale
Registration Statement or the receipt, by the Borrower, of any notice that proceedings for such purpose have been initiated or threatened;
(v) the
receipt, by the Borrower, of any notice (x) of the suspension of the qualification or exemption from qualification of the offer and sale
of the Registrable Securities in any jurisdiction; or (y) that proceedings for such purpose have been initiated or threatened;
(vi) the withdrawal or lifting of any suspension referred to in clause (iv) or (v) above; and
(vii)
that the Borrower has determined that the use of the General Resale Registration Statement must be suspended (which notice may,
at the Borrower’s discretion, state that it constitutes a Blackout Commencement Notice), including as a result of the occurrence
of any event that causes any of the General Resale Registration Statement Documents to have a Material Disclosure Defect or to cease
to comply with applicable law;
provided,
however, that (x) the Borrower need not provide any such notice during a Blackout Period; and (y) in no event will this Section
7(e) require the Borrower to, and in no event will the Borrower, provide any information that it in good faith determines would constitute
material non-public information. In addition, during the pendency of any Demand Underwritten Offering pursuant to Section 4 or
any Piggyback Underwritten Offering pursuant to Section 5, but other than during a Blackout Period, the Borrower will provide
notice of each Notice Holder whose Registrable Securities are to be sold in such offering pursuant to the related Demand Underwriting
Registration Statement or Piggyback Registration Statement, as applicable, which such Notice Holders will be afforded the same notice
set forth in clauses (i) through (vii), inclusive, of this Section 7(e) relating to such Registration Statement.
(f) Remediation
of Material Disclosure Defects. Subject to Section 6, the Borrower will, as promptly as practicable after determining that
any Registration Statement Document contains a Material Disclosure Defect, prepare and file with the SEC (and, if applicable, use its
commercially reasonable efforts to cause the same to become effective under the Securities Act as promptly as practicable) such appropriate
additional Registration Statement Document(s) so as to cause the applicable Registration Statement Document(s) to thereafter not contain
any Material Disclosure Defect.
(g)
Listing of Registrable Securities. The Borrower will cause the Registrable
Securities to be
listed for trading on each U.S. national securities exchange, if any, on which
securities of the
same class of the Borrower are then so listed. To the extent the Common Shares of the Company cease to be listed on the Relevant Stock
Exchange, the Company will use its
best efforts to
take all actions reasonably necessary to re-list on the Relevant Stock Exchange, except in the event of a Take-Private Transaction (as
defined herein).
(h)
Provision of Copies of the Prospectus. At its expense, the Borrower will provide, to Notice Holders and the Managing
Underwriters, if any, such number of copies of the prospectus relating to the applicable Registration Statement or any related prospectus
supplement or “issuer free writing prospectus” (as defined in Rule 433 under the Securities Act) as such Notice Holders or
Managing Underwriters, as applicable, may reasonably request in writing; provided, however, that the Borrower need not
provide any document pursuant to this Section 7(h) that is publicly available on the SEC’s EDGAR system (or any successor
thereto).
(i)
Holders Cannot Be Named as Underwriters Without Consent. The Borrower will not expressly name or identify any Holder
as an “underwriter” in any Registration Statement Document without such Holder’s prior written consent (including consent
provided in a Notice and Questionnaire); provided, however, that nothing in this Section 7(i) will require the consent
of any Holder in connection with the inclusion in any Registration Statement Document of customary language, without naming any Holder,
that selling securityholders may in certain circumstances be considered to be underwriters under federal securities laws.
(j)
Due Diligence Matters. Upon reasonable notice and written request, and at reasonable times during normal business hours,
the Borrower will make available for inspection by a representative of each Notice Holder, and the Managing Underwriters, if any, and
any attorneys or accountants retained by such Notice Holder or Managing Underwriters, as applicable, customary due diligence information.
(k)
Earnings Statement. The Borrower will use its commercially reasonable efforts to comply with its reporting obligations
under Section 13(a) or 15(d) of the Exchange Act in such manner, as contemplated under Rule 158 under the Securities Act, so as to make
generally available to its securityholders an earnings statement covering the twelve (12) month period referred to in Section 11(a) of
the Securities Act, as it relates to each applicable Registration Statement, in the manner contemplated by, and otherwise in compliance
with, such Section 11(a).
(l)
Settlement of Transfers and De-Legending. The Borrower will use its commercially reasonable efforts to cause its transfer
agent (or any other securities custodian for any Registrable Securities) to cooperate in connection with the settlement of any transfer
of Registrable Securities pursuant to any Registration Statement, including through the applicable Depositary, provided that any
related documentation, if reasonably required, be medallion-guaranteed. If any such Registrable Securities so transferred are represented
by a certificate bearing a legend referring to transfer restrictions under the Securities Act, then the Borrower will, if appropriate,
cause such Registrable Securities to be reissued in the form of one or more certificates not bearing such a legend.
(m)
Certain Covenants Relating to Underwritten Offerings. The following covenants will apply, in each case to the extent
applicable, in connection with any Piggyback Underwritten Offering that includes any Registrable Securities, or any Demand Underwritten
Offering:
(i)
Underwriting Agreement and Related Matters. The Borrower will (1) subject to Section 4(d)(iii)(3) and Section 5(b)(iii)(3),
execute and deliver any customary underwriting agreement or other agreement or instrument reasonably requested in writing by the Managing
Underwriters for such offering; (2) use commercially reasonable efforts to cause such customary legal opinions, comfort letters, “lock-up”
agreements and officers’ certificates to be delivered in connection therewith; and (3) cooperate in good faith with such Managing
Underwriters in connection with the disposition of Registrable Securities pursuant to such offering.
(ii)
Marketing and Roadshow Matters. The Borrower will cooperate in good faith with the Managing Underwriters for such offering
in connection with any marketing activities relating to such offering.
(iii)
FINRA Matters. The Borrower will cooperate and assist in any filings required to be made with the Financial Industry Regulatory
Authority, Inc. in connection with such offering.
Section
8.
Expenses. All Borrower Registration Expenses will be borne by Borrower. All fees and expenses that are incurred by any
Holder in connection with this Agreement, and that are not Borrower Registration Expenses, will be borne by such Holder.
Section
9.
Accrual of Additional Interest During Registration Default Events.
(a)
Generally. Subject to Section 9(b), Additional Interest will accrue, as provided in Section 9(c),
(1)
on all of the outstanding Registrable Securities for each day during the General Resale Registration Statement Effectiveness Period
on which the General Resale Registration Statement is not on file with the SEC, effective under the Securities Act or usable for the
resale or other transfer of Registrable Securities in the manner required by Section 3(a);
(2) on each outstanding Registrable Security (and only such Registrable Security) for each day on which the resale of such Registrable
Security, is required by Section 3(b)(ii) to be, but is not, covered by the General Resale Registration Statement; and
(3) on any outstanding Registrable Security (and only such Registrable for each day after the deadline, set forth in Section 3(c),
by which a filing is required by Section 3(c) to be made, but has not yet been made, with respect to such Registrable Security
in accordance therewith.
(b)
No Accrual of Registration Default Fee During any Blackout Period, Etc. Notwithstanding anything to the contrary in
this Section 9, (i) no Registration Default Event will occur on any day (i) during any Blackout Period that does not exceed the
limitations set forth in
Section 6(b);
(ii) after the Registration Statement Effectiveness Period; or (iii) from and after the time the Borrower’s obligations under this
Agreement with respect to the General Resale Registration Statement have terminated pursuant to Section 12.
(c)
Accrual and Payment of Additional Interest. Any Additional Interest that accrues on the Loan pursuant to Section
9(a) will accrue and be payable in the manner, and at the rates, set forth in Section 3.06 of the Terms and Conditions.
Section
10. Certain
Agreements and Representations of the Holders.
(a)
Provision of Information. Notwithstanding anything to the contrary in this Agreement, no Holder will be entitled to
any benefits under this Agreement until it has executed and delivered a Notice and Questionnaire to the Borrower. Each Holder represents
that the information included in any such Notice and Questionnaire is accurate in all material respects and covenants, during the term
of this Agreement, to promptly provide notice to the Borrower if any such information thereafter ceases to be accurate in all material
respects. Each Holder authorizes the Borrower to assume the accuracy and completeness of all information contained in the most recent
Notice and Questionnaire executed and delivered by such Holder. Each Holder will (i) provide, as soon as reasonably practicable, such
other information as the Borrower may reasonably request in connection with the performance of the Borrower’s obligations under
this Agreement; and (ii) promptly notify the Borrower upon becoming aware that any information relating to such Holder and included in
any Registration Statement Document contains a Material Disclosure Defect.
(b)
Use of Offering Materials. Each Holder agrees that, without the prior written consent of the Borrower, it will not
offer or sell any Registrable Securities by means of any written communication other than the latest prospectus or prospectus supplement
provided to such Holder by the Borrower (or on file on SEC’s EDGAR system (or any successor thereto)) relating to the applicable
Registration Statement, and any related “issuer free writing prospectus” (as defined in Rule 433 under the Securities Act)
authorized for such use by the Borrower.
(c)
Covenants Relating to Blackout Periods. Each Holder agrees that, upon its receipt of a Blackout Commencement Notice,
such Holder will not effect any sale or other transfer of Registrable Securities pursuant to any Registration Statement, and will not
distribute any Registration Statement Document, until such Holder has received a subsequent Blackout Termination Notice.
Section
11. Indemnification
and Contribution.
(a)
Indemnification by the Borrower. The Borrower will indemnify, defend and hold harmless each Holder Indemnified Person
from and against (and will reimburse such Holder Indemnified Person, as incurred, for) any Losses that, jointly or severally, such Holder
Indemnified Person may incur under the Securities Act, the Exchange Act, the common law or otherwise, insofar as such Losses arise out
of or are based on (i) any Material Disclosure Defect or alleged Material Disclosure Defect in any Registration Statement Document; or
(ii) any violation by the Borrower of the Securities Act, the Exchange Act or any other U.S. federal securities laws, or any U.S. state
securities or “blue sky” laws, in connection with any
Registration Statement
Document; provided, however, that the Borrower will have no obligations under this Section 11(a) in respect of any
Losses insofar as such Losses arise out of or are based on any Material Disclosure Defect or alleged Material Disclosure Defect included
in any Registration Statement Document in conformity with the Holder Information of any Holder.
(b)
Indemnification by the Holders. Each Person that is a signatory to this Agreement or that is a Notice Holder, severally
and not jointly, will indemnify, defend and hold harmless each Borrower Indemnified Person from and against (and will reimburse such
Borrower Indemnified Person, as incurred, for) any Losses that, jointly or severally, such Borrower Indemnified Person may incur under
the Securities Act, the Exchange Act, the common law or otherwise, insofar as such Losses arise out of or are based on any Material Disclosure
Defect or alleged Material Disclosure Defect in any Registration Statement Document, which Material Disclosure Defect or alleged Material
Disclosure Defect is included therein in conformity with the Holder Information of such Holder; provided, however, that
in no event will the liability of any Holder pursuant to this Section 11(b) exceed a dollar amount equal to the proceeds received
by such Holder (less any related discounts, commissions, transfer taxes, fees or other expenses) from the sale of the Registrable Securities
giving rise to the related indemnification obligation under this Section 11(b).
(c)
Indemnification Procedures.
(i)
Notice of Proceedings. If any claim, action, suit or proceeding (each, a “Proceeding”) is made or commenced
against any Indemnified Person in respect of which indemnity is or may be sought from any Person (in such capacity, the “Indemnifying
Party”) pursuant to Section 11(a) or Section 11(b), then such Indemnified Person will promptly notify the such
Indemnifying Party in writing of such Proceeding; provided, however, that the failure to so notify such Indemnifying Party
will not relieve such Indemnifying Party from any liability that it may have to such Indemnified Person or otherwise.
(ii)
Defense of Proceedings; Employment of Counsel. Subject to the next sentence, upon its receipt of the notice referred to
in Section 11(c)(i) in respect of a Proceeding, the Indemnifying Party will assume the defense of such Proceeding, including the
employment of counsel reasonably satisfactory to the Indemnified Person and payment of all fees and expenses. Such Indemnified Person
will also have the right to employ its own counsel in such Proceeding at such Indemnified Person’s expense; provided, however,
that such Indemnifying Party will be responsible for, and pay as incurred, the reasonable fees and expenses of such counsel if (1) such
Indemnifying Party authorized, in writing, the employment of such counsel in connection with the defense of such Proceeding; (2) such
Indemnifying Party fails, within a reasonable period of time in light of the circumstances, to employ counsel to defend such Proceeding;
or (3) such Indemnified Person reasonably concludes that there may be defenses available to such Indemnified Person that are different
from, in addition to, or in conflict with, those available to such Indemnifying Party (in which case of this clause (3), such
Indemnifying Party will not have the right to direct the defense of such Proceeding on behalf of such Indemnified Person). Notwithstanding
anything to the contrary in this Section 11(c)(ii), in no event will any Indemnifying Party be liable for the fees or expenses
of more than
one
separate counsel (in addition to any local counsel) in any one Proceeding or series of related Proceedings in the same jurisdiction representing
the Indemnified Person(s) who are parties to such Proceeding.
(iii)
Settlements of Proceedings. An Indemnifying Party will not be liable pursuant to Section 11(a) or Section 11(b),
as applicable, or this Section 11(c) for any settlement of any Proceeding except as provided in the next sentence. If any Proceeding
is settled, then the Indemnifying Party will indemnify and hold harmless each Indemnified Person that is subject to such settlement from
and against any Losses incurred by such Indemnified Person by reason of such settlement, if:
(1) such
Indemnifying Party effected, or otherwise provided its written consent to, such settlement (which consent will not be unreasonably withheld
or delayed); or
(2) (A)
such Indemnified Person has requested such Indemnifying Party to reimburse such Indemnified Person for any fees and expenses of counsel
as contemplated by Section 11(c)(ii); (B) such settlement is entered into more than sixty (60) Business Days after such Indemnifying
Party has received such request; (C) such Indemnifying Party has not fully reimbursed such Indemnified Person in accordance with such
request before the date of such settlement; and (D) such Indemnified Person has given such Indemnifying Party at least thirty (30) days’
prior notice of its intention to settle.
The Indemnifying
Party will not effect any settlement of any Proceeding without the prior written consent of the applicable Indemnified Person(s), unless
such settlement (1) includes an unconditional release of such Indemnified Person(s) from all liability on the claims that are the subject
matter of such Proceeding; (2) does not include an admission of fault or culpability or a failure to act by or on behalf of such Indemnified
Person(s); and (3) does not purport to bind the Indemnified Persons(s) to perform or refrain from performing any act (excluding any provision
providing for the payment of money by the Indemnified Persons(s), which, for the avoidance of doubt, will be subject to the indemnity
provided in the second sentence of this Section 11(c)(iii)).
(d)
Contribution Where Indemnification Not Available. If the indemnification provided for in this Section 11 is
unavailable to any Indemnified Person, or is insufficient to hold any Indemnified Person harmless, in respect of any Losses referred
to in the preceding provisions of this Section 11, then each applicable Indemnifying Party, severally and not jointly, will contribute
to the amount paid or payable by such Indemnified Person as a result of such Losses in such proportion as is appropriate to reflect the
relative fault of the Borrower, on the one hand, and of the Holders, on the other hand, in connection with the statements or omissions,
or the actions or non-actions, as applicable, that resulted in such Losses, as well as other relevant equitable considerations. The relative
fault of the Borrower, on the one hand, and of the Holders, on the other hand, will be determined by reference to, among other things,
whether any applicable Material Disclosure Defect or alleged Material Disclosure Defect, or any relevant action or non-action, as applicable,
relates to information supplied, or was taken or made, as applicable, by the Borrower or by the Holders and the parties’ relative
intent, knowledge, access
to information
and opportunity to correct or prevent such Material Disclosure Defect or alleged Material Disclosure Defect, or such action or non-action,
as applicable,. The amount paid or payable by an Indemnified Person as a result of any Losses referred to in this Section 11(d)
will include any legal or other fees or expenses reasonably incurred by such Indemnified Person in connection with investigating, preparing
to defend or defending the related Proceeding.
The
Borrower and the Holders agree that it would not be just and equitable if contribution pursuant to this Section 11(d) were determined
by pro rata allocation (even if the Holders were treated as one Person for such purpose) or by any other allocation method that does
not take account of the equitable considerations referred to in the preceding paragraph. Notwithstanding anything to the contrary in
the preceding paragraph, no Holder will be required to contribute any amount in excess of the amount by which the proceeds received by
such Holder (less any related discounts, commissions, transfer taxes, fees or other expenses) from the sale of Registrable Securities
giving rise to the related contribution obligation under this Section 11(b) exceeds the amount of any damage that such Holder
has otherwise been required to pay by reason of the relevant Material Disclosure Defect or alleged Material Disclosure Defect, or the
relevant action or non-action, as applicable. No Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. The Holders’
obligations to contribute pursuant to this Section 11(d) are several and not joint.
(e)
Remedies Not Exclusive. The remedies provided for in this Section 11 are not exclusive and will not limit, and
will be in addition to, any rights or remedies that may otherwise be available to any Indemnified Person at law or in equity.
Section
12. Termination
of Registration Rights.
(a)
General Resale Registration Statement. Notwithstanding anything to the contrary in this Agreement, the Borrower’s
obligations under Section 3, and any related obligations of the Borrower under Section 7, will terminate (and, for the
avoidance of doubt, the Borrower will thereafter have no obligation to file, keep effective or usable, or amend or make and other filings
with respect to, the General Resale Registration Statement or any other General Resale Registration Statement Document) upon the earlier
of (i) a Fundamental Change, the result of which the Company is “taken private,” ceasing to be subject to ongoing securities
law and relevant SEC reporting requirements under Section 12(g) of the Exchange Act (a “Take-Private Transaction”)
and (ii) the first date on which no Registrable Securities are outstanding.
(b)
Demand Underwriting Registration Rights. Notwithstanding anything to the contrary in this Agreement, the Borrower’s
obligations under Section 4, and any related obligations of the Borrower under Section 7, will terminate (and, for the
avoidance of doubt, the Borrower will thereafter have no obligation to effect any Demand Underwritten Offering) upon the earlier of (i)
a Take-Private Transaction and (ii) the first date on which no Registrable Securities are outstanding.
(c)
Piggyback Registration Rights. Notwithstanding anything to the contrary in this Agreement, the Borrower’s obligations
under Section 5, and any related obligations of the Borrower under Section 7, will terminate (and, for the avoidance of
doubt, the Borrower will
thereafter have
no obligation to include any Registrable Securities in any Piggyback Underwritten Offering) upon the earlier of (i) a Take Private Transaction
and (ii) the first date on which no Registrable Securities are outstanding.
Section
13. Subsequent
Holders. Each Person that acquires any Registrable Securities from any Holder will, to the extent such securities continue to constitute
Registrable Securities in the hands of such Person, become a Holder; provided, however, that such Person will not be entitled
to the benefits of this Agreement (and will be deemed not to be a Holder or a Notice Holder) unless such Person promptly, and in any
event within five (5) Business Days after acquiring such securities, execute and deliver a Notice and Questionnaire to the Borrower agreeing
to be bound by the terms of this Agreement.
Section
14. Miscellaneous.
(a)
Notices. The Borrower will send all notices or communications to any Holder pursuant to this Agreement either (a) in
writing by first class mail, certified or registered, return receipt requested, or by overnight air courier guaranteeing next day delivery,
to such Holder’s address as set forth in the latest Notice and Questionnaire of such Notice Holder delivered to the Borrower (or,
if such Holder has not delivered any Notice and Questionnaire, as set forth in the Borrower’s registrar); or (b) by email to the
email address specified in such Notice and Questionnaire (which email will be deemed to constitute notice in writing for purposes of
this Agreement).
Any
notice or communication by any Holder to the Borrower will be deemed to have been duly given if in writing by first class mail, certified
or registered, return receipt requested, or by overnight air courier guaranteeing next day delivery, to offices of the Borrower at the
following address (or at such other address as may be hereafter specified by notice to the Holders by the Borrower):
Centogene
N.V.
Am Strande
7
18055
Rostock
Germany
Attention:
[***]
Email:
[***]
with
a copy (which will not constitute notice) to:
Davis
Polk & Wardwell London LLP
5
Aldermanbury Square
London
EC2V 7HR
United
Kingdom
Attention:
Leo Borchardt
And
Davis
Polk & Wardwell LLP
450
Lexington Avenue
New
York, NY 10017
United
States
Attention:
David Hahn
And
NautaDutilh
N.V.
Beethovenstraat
400
1082
PR Amsterdam
The
Netherlands
Attn:
Paul van der Bijl
Email:
Paul.vanderBijl@nautadutilh.com
(b)
Amendments and Waivers. This Agreement, of any provision of this Agreement, may be amended, modified, waived or superseded
only by a written instrument that is executed by the Borrower and by one or more Holders whose aggregate As-Converted Registrable Securities
Ownership Percentage exceeds fifty percent (50%), and any such amendment, modification, waiver or supersession so executed will be binding
upon the Borrower and all Holders; provided, however, that (i) no amendment, modification, waiver or supersession of Section
9 (including the events that constitute a Registration Default Event) or this Section 14(b), or any related definitions, will
be effective as to any Holder or the Lender unless reflected in a written instrument executed by such Holder or such Lender, as applicable;
(ii) a waiver with respect to any particular Holder’s rights under this Agreement will be effective as to such Holder if reflected
in a written instrument executed by such Holder, provided such waiver does not adversely affect the rights of any other Holder; (iii)
waiver of any rights of the Holders in respect of any Piggyback Underwritten Offering will be effective if reflected in a written instrument
executed by Notice Holders holding a majority of the total number of Registrable Securities of Notice Holders proposed to be sold in
such Piggyback Underwritten Offering; and (iv) no amendment, modification, waiver or supersession that affects any rights of the Lender
or any Holders in respect of any Demand Underwritten Offering will be effective as to the Lender or the Holders, as applicable, unless
reflected in a written instrument executed by the Lender or Notice Holders holding a majority of the total number of Registrable Securities
of Notice Holders proposed to be sold in such Demand Underwritten Offering, respectively.
For
purposes of determining whether any such amendment, modification, waiver or supersession is executed by Holders of the requisite number
of securities, the Borrower may, absent manifest error, conclusively rely on information contained in its registrar or in any Notice
and Questionnaire.
No
delay on the part of any party in exercising any right, power or privilege pursuant to this Agreement will operate as a waiver thereof,
and no waiver, or single or partial exercise of, any such right, power or privilege will preclude any other or further exercise thereof
or the exercise of any other right, power or privilege pursuant to this Agreement.
(c)
Third Party Beneficiaries. Subject to Section 13, this Agreement will be binding on, inure to the benefit of
and be enforceable by, each Holder and its successors and assigns.
(d)
Governing Law; Waiver of Jury Trial.. THIS AGREEMENT, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED
TO THIS AGREEMENT, WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH OF THE BORROWER AND THE
LENDER IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING
ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT.
(e)
Arbitration. The Borrower and each Holder agrees that any dispute, difference, claim, question or controversy arising
out of or in connection with this Agreement, which is not amicably settled between the Borrower and any Holder within a period of one
month from the date of the start of negotiations between the Borrower and any Holder, shall be finally resolved pursuant to arbitration
pursuant to the terms set forth in this Section 14(e). New York, New York will be the place of arbitration. Arbitration shall
be governed by Judicial Arbitration & Mediation Services (“JAMS”) and its JAMS Comprehensive Rules and
Procedures (“JAMS Rules”) in effect at the time the arbitration is commenced. A panel of three neutral arbitrators
will be selected in accordance with the JAMS Rules to conduct the arbitration. The arbitration shall be conducted in English. The arbitral
award shall be final and enforced in any court of competent jurisdiction by either party. To the extent permissible by applicable law,
the Borrower and each Holder hereby waive any right to appeal the decision of the arbitration. The arbitral tribunal may award legal
costs and expenses as it deems fit. The Borrower and each Holder hereby acknowledge and agree that arbitrators may issue procedural orders
and decide on interim measures/injunctions in the course of the arbitration. The Borrower and each Holder agree that any one of them
may request in aid of arbitration from any court of competent jurisdiction, injunctive relief or other conservatory measures.
(f)
No Adverse Interpretation of Other Agreements.. This Agreement may be used to interpret any other agreement of the
Borrower or its subsidiaries or of any other Person, and no such agreement may be used to interpret this Agreement.
(g)
Successors. All agreements of the Borrower in this Agreement will bind its successors.
(h)
Severability. If any provision of this Agreement is invalid, illegal or unenforceable, then the validity, legality
and enforceability of the remaining provisions of this Agreement will not in any way be affected or impaired thereby.
(i)
Counterparts. The parties may sign any number of copies of this Agreement. Each signed copy will be an original, and
all of them together represent the same agreement. Delivery of an executed counterpart of this Agreement by facsimile, electronically
in portable document format or in any other format will be effective as delivery of a manually executed counterpart.
(j)
Table of Contents, Headings, Etc. The table of contents and the headings of the
Sections and Subsections
of this Agreement have been inserted for convenience of reference only, are not to be considered a part of this Agreement and will in
no way modify or restrict any of the terms or provisions of this Agreement.
(k)
Service of Process. The Borrower irrevocably appoints Centogene US, LLC, which currently maintains an office at 99
Erie St, Cambridge, MA 02139, United States of America, as its authorized agent in Cambridge upon which process may be served in any
suit, action or proceeding referred to in Section 14(e), and agrees that service of process upon such agent, and written notice
of such service to the Borrower by the person serving the same to Centogene N.V., Am Strande 7, 18055 Rostock, Germany, Attention: [***], will be, in every respect, effective service of process upon the Borrower in any such suit, action or proceeding.
If, for any reason, such agent ceases to be such agent for service of process, then the Borrower will promptly appoint a new agent of
recognized standing for service of process in Massachusetts and deliver to the Lender and the Notice Holders a copy of the new agent’s
acceptance of that appointment within ten (10) Business Days of such acceptance. Nothing in this Section 14(k) will affect the
right of the Lender or any Holder to serve process in any other manner permitted by law or to commence legal proceedings or otherwise
proceed against the Borrower in any other court of competent jurisdiction. To the extent that the Borrower has or hereafter may acquire
any sovereign or other immunity from jurisdiction of any court or from any legal process with respect to itself or its property, the
Borrower irrevocably waives such immunity in respect of its obligations under this Agreement.
(l)
Entire Agreement. This Agreement, including Exhibit A, constitutes the entire agreement of the parties with
respect to the specific subject matter of this Agreement and supersedes in their entirety all other agreements or understandings (whether
written or oral) between or among the parties with respect to such specific subject matter.
(m)
Specific Performance. The Borrower (a) agrees that any failure by it to comply with its obligations under this Agreement
may result in material irreparable injury to the Holders for which there is no adequate remedy at law, and, that upon any such failure,
any Holder may obtain such relief as may be required to specifically enforce the Borrower’s obligations under this Agreement; and
(b) hereby waives the defense in any action for specific performance that a remedy at law would be adequate.
[The Remainder
of This Page Intentionally Left Blank; Signature Page Follows]
IN
WITNESS WHEREOF, the parties to this Agreement have caused this Agreement to be duly executed as of the date first written above.
|
Centogene
N.V. |
|
|
|
|
|
By: |
/s/ Kim Stratton |
|
|
Name: Kim Stratton |
|
|
Title: Chief Executive Officer |
[Signature Page to Second Registration Rights Agreement]
|
Pharmaceutical
Investment Company |
|
|
|
|
|
By: |
/s/ Ibrahim Abdulrahman I Aljuffali |
|
|
Name: Dr. Ibrahim Abdulrahman I Aljuffali |
|
|
Title: Chairman |
[Signature Page to Second Registration Rights Agreement]
EXHIBIT A
FORM OF NOTICE
AND QUESTIONNAIRE
The undersigned
(the “Selling Securityholder”) beneficial owner of common shares, par value €0.12 per share (the “Common
Shares”), or other Registrable Securities (as defined in the Second Registration Rights Agreement referred to below) of Cenotogene,
N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands (the “Borrower”)
understands that the Borrower has filed, or intends to file, with the Securities and Exchange Commission (the “SEC”)
a registration statement (the “Registration Statement”) under the Securities Act of 1933, as amended (the “Securities
Act”) to register the resale of Registrable Securities, in accordance with the terms of the Second Registration Rights Agreement,
dated as of October 26, 2023 (the “Second Registration Rights Agreement”), between the Borrower and the Lender named
therein. The Borrower will provide a copy of the Second Registration Rights Agreement upon written request at the address set forth below.
All capitalized terms used in this Notice and Questionnaire without definition have the respective meanings given to them in the Second
Registration Rights Agreement.
To sell or otherwise
dispose of any Registrable Securities pursuant to the Registration Statement, the beneficial owner of those Registrable Securities generally
must be named as a selling securityholder in the related prospectus, deliver a prospectus to the purchasers of the Registrable Securities
and be bound by those provisions of the Second Registration Rights Agreement applicable to such beneficial owner (including certain indemnification
provisions, as described below). Beneficial owners of any Registrable Securities that do not complete this Notice and Questionnaire and
deliver it to the Borrower as provided below will not be named as selling securityholders in the prospectus and will not be permitted
to sell any Registrable Securities pursuant to the Registration Statement. Beneficial owners are encouraged to complete and deliver this
Notice and Questionnaire as soon as possible.
Please note
that if the Common Shares held by you or which may be held by you do not meet the definition of “Registrable Securities”
set forth in the Second Registration Rights Agreement, the Borrower is not required to register your securities and you will not be named
as a selling securityholder in the Registration Statement.
Certain legal consequences
arise from being named as a selling securityholder in the Registration Statement and the related prospectus. Accordingly, registered
holders and beneficial owners of Registrable Securities should consult their legal counsel regarding the consequences of being named
or not being named as a selling securityholder in the Registration Statement and the related prospectus.
NOTICE
By signing and
returning this Notice and Questionnaire, the Selling Securityholder:
| · | notifies
the Borrower of its intention to sell or otherwise dispose of Registrable Securities beneficially
owned by it and listed below in Item 3 (except as otherwise specified under such Item 3)
pursuant to the Registration Statement; and |
| · | agrees
to be bound by the terms and conditions of this Notice and Questionnaire and the Second Registration
Rights Agreement. |
Pursuant to the
Second Registration Rights Agreement, the Selling Securityholder has agreed to indemnify and hold harmless the Borrower and its affiliates,
the partners, directors, officers, members, shareholders, employees, advisors or other representatives of the Borrower or its affiliates,
and each person, if any, who controls the Borrower within the meaning of Section 15 of the Securities Act or Section 20 of the Securities
Exchange Act of 1934, as amended (the “Exchange Act”), from and against certain claims and losses arising in connection
with statements or omissions concerning the Selling Securityholder made in the Registration Statement or the related prospectus in reliance
upon the information provided in this Notice and Questionnaire.
The Selling Securityholder
hereby provides the following information to the Borrower and represents and warrants that such information is accurate and complete:
QUESTIONNAIRE
Please respond
to every item, even if your response is “none.” If you need more space for any response, please attach additional sheets
of paper. Please be sure to indicate your name and the number of the item being responded to on each such additional sheet of paper,
and to sign each such additional sheet of paper before attaching it to this Notice and Questionnaire. Please note that you may be asked
to answer additional questions depending on your responses to the following questions.
| 1. | Selling Securityholder
Information: |
| (a) | Full legal
name of the Selling Securityholder: |
| (b) | If the
Registrable Securities listed in Item 3 below are held in certificated form and not “in
street name,” state the full legal name of the registered holder through which the
Registrable Securities listed in Item 3 below are held: |
| (c) | If the
Registrable Securities listed in Item 3 below are held “in street name,” state
the full legal name of the Depository Trust Company participant through which the Registrable
Securities listed in Item 3 below are held: |
| (d) | Taxpayer
identification or social security number of the Selling Securityholder: |
| 2. | Address and
Contact Information for Notices to the Selling Securityholder: |
| 3. | Beneficial
Ownership of Common Shares Issued Upon Conversion of the Loan: |
| ☐ | I own
Common Shares that were issued upon conversion of the Loan: |
| 4. | Beneficial
Ownership of Other Securities of the Borrower: |
Except
as set forth below in this Item 4, the Selling Securityholder is not the beneficial or registered owner of any securities of the Borrower
other than the securities listed in Item 3 above.
Type
and amount of other securities beneficially owned by the Selling Securityholder:
|
Title of Security |
Amount
Beneficially Owned |
CUSIP
No(s). (If Any) |
| 5. | Relationships
with the Borrower: |
| (a) | Has the
Selling Securityholder or any of its affiliates, officers, directors or principal equity
holders (owners of 5% or more of the equity securities of the Selling Securityholder) held
any position or office or had any other material relationship with the |
Borrower
(or its predecessors or affiliates) during the past three years?
| (b) | If the
response to (a) above is “Yes,” then please state the nature and duration of
the relationship with the Borrower: |
Check
the following box confirming the intended plan of distribution of the Registrable Securities:
| ☐ | The Selling
Securityholder (including its donees and pledgees) does not intend to distribute the Registrable
Securities listed in Item 3 above pursuant to the Shelf Resale Registration Statement except
as follows (if at all): |
The Registrable
Securities may be sold from time to time directly by the Selling Securityholder or, alternatively, through underwriters, broker-dealers
or agents. If the Registrable Securities are sold through broker-dealers or agents, the Selling Securityholder will be responsible for
underwriting discounts or commissions or agents’ commissions. The Registrable Securities may be sold in one or more transactions
at fixed prices, at prevailing market prices at the time of sale, at varying prices determined at the time of sale or at negotiated prices.
Such sales may be effected in transactions (which may involve block transactions) (1) on any national securities exchange or quotation
service on which the Registrable Securities may be listed or quoted at the time of sale; (2) in the over-the-counter market; (3) otherwise
than on such exchanges or services or in the over-the-counter market; or (4) through the writing of options. In connection with sales
of the Registrable Securities or otherwise, the Selling Securityholder may enter into hedging transactions with broker-dealers, which
may in turn engage in short sales of the Registrable Securities in the course of the hedging positions they assume. The Selling Securityholder
may also sell Registrable Securities short and deliver Registrable Securities to close out short positions or loan or pledge Registrable
Securities to broker-dealers that in turn may sell such securities. Notwithstanding anything to the contrary, in no event will the methods
of distribution take the form of an underwritten offering of the Registrable Securities without the prior agreement of the Borrower.
State
any exceptions:
| 7. | Broker-Dealers
and Their Affiliates: |
The
Borrower may have to identify the Selling Securityholder as an underwriter in the Registration Statement or related prospectus if:
| · | the
Selling Securityholder is a broker-dealer and did not receive the Registrable Securities
as compensation for underwriting activities or investment banking services or as investment
securities; or |
| · | the
Selling Securityholder is an affiliate of a broker-dealer and either (1) did not acquire
the Registrable Securities in the ordinary course of business; or (2) at the time of its
purchase of the Registrable Securities, had an agreement or understanding, directly or indirectly,
with any person to distribute the Registrable Securities. |
Persons
identified as underwriters in the Registration Statement or related prospectus may be subject to additional potential liabilities under
the Securities Act and should consult their legal counsel before submitting this Notice and Questionnaire.
| (a) | Is the
Selling Securityholder a broker-dealer registered pursuant to Section 15 of the Exchange
Act? |
| (b) | If the
response to (a) above is “No,” is the Selling Securityholder an “affiliate”
of a broker-dealer that is registered pursuant to Section 15 of the Exchange Act? |
For the
purposes of this Item 7(b), an “affiliate” of a registered broker-dealer includes any company that directly, or indirectly
through one or more intermediaries, controls, or is controlled by, or is under common control with, such broker-dealer.
| (c) | Did the
Selling Securityholder acquire the securities listed in Item 3 above in the ordinary course
of business? |
| (d) | At the
time of the Selling Securityholder’s purchase of the securities listed in Item 3 above,
did the Selling Securityholder have any agreements or understandings, directly or indirectly,
with any person to distribute the securities? |
| (e) | If the
response to (d) above is “Yes,” then please describe such agreements or understandings: |
| (f) | Did the
Selling Securityholder receive the securities listed in Item 3 above as compensation for
underwriting activities or investment banking services or as investment securities? |
| (g) | If the
response to (f) above is Yes,” then please describe the circumstances: |
| 8. | Nature of
Beneficial Ownership: |
The
purpose of this section is to identify the ultimate natural person(s) or publicly held entity(ies) that exercise(s) sole or shared voting
or dispositive power over the Registrable Securities.
| (a) | Is the
Selling Securityholder a natural person? |
| (b) | Is the
Selling Securityholder required to file, or is it a wholly owned subsidiary of an entity
that is required to file, periodic and other reports (for example, Forms 10-K, 10-Q |
and 8-K)
with the SEC pursuant to Section 13(a) or 15(d) of the Exchange Act?
| (c) | Is the
Selling Securityholder an investment company, or a subsidiary of an investment company, registered
under the Investment Company Act of 1940, as amended? |
| (d) | If the
Selling Securityholder is a subsidiary of such an investment company, please identify the
investment company: |
| (e) | Identify
below the name of each natural person or entity that has sole or shared investment or voting
control over the securities listed in Item 3 above: |
PLEASE
NOTE THAT THE SEC REQUIRES THAT THESE NATURAL PERSONS AND ENTITIES BE NAMED IN THE PROSPECTUS
| 9. | Securities
Received from Named Selling Securityholder: |
| (a) | Did the
Selling Securityholder receive the Registrable Securities listed above in Item 3 as a transferee
from selling securityholder(s) previously identified in the Registration Statement? |
| (b) | If the
response to (a) above is “Yes,” then please answer the following two questions: |
| (i) | Did the
Selling Securityholder receive the Registrable Securities listed above in Item 3 from the
named selling securityholder(s) prior to the effectiveness of the Registration Statement? |
| (ii) | Identify
below the names of the selling securityholder(s) from whom the Selling Securityholder received
the Registrable Securities listed above in Item 3 and the date on which such securities were
received. |
If more space is
needed for responses, then please attach additional sheets of paper. Please indicate the Selling Securityholder’s name and the
number of the item being responded to on each such additional sheet of paper, and sign each such additional sheet of paper, before attaching
it to this Notice and Questionnaire. The Selling Securityholder may be asked to answer additional questions depending on the responses
to the above questions.
ACKNOWLEDGEMENTS
The Selling Securityholder
acknowledges its obligation to comply with the provisions of the Exchange Act and the rules thereunder relating to share manipulation,
particularly Regulation M thereunder (or any successor rules or regulations), in connection with any offer or sale of Registrable Securities.
The Selling Securityholder agrees that neither it nor any person acting on its behalf will engage in any transaction in violation of
such provisions.
The Selling Securityholder
acknowledges its obligations under the Second Registration Rights Agreement to indemnify and hold harmless certain persons as set forth
therein.
Pursuant to the
Second Registration Rights Agreement, the Borrower has agreed under certain circumstances to indemnify the Selling Securityholder against
certain liabilities.
In accordance with
the Selling Securityholder’s obligation under the Second Registration Rights Agreement to provide such information as may be required
by law for inclusion in the Resale Registration Statement, the Selling Securityholder agrees to promptly notify the Borrower of any inaccuracies
or changes in the information provided in this Notice and Questionnaire that may occur after the date of this Notice and Questionnaire
at any time while the Resale Registration
Statement remains
effective.
Notices to the
Selling Securityholder relating to this Notice and Questionnaire or pursuant to the Second Registration Rights Agreement will be made
by email, or in writing, at the email or physical address set forth in Item 2 above.
By signing below,
the Selling Securityholder acknowledges that it is the beneficial owner of the Registrable Securities set forth herein, represents that
the information provided herein is accurate in all material respects and consents to the disclosure of the information contained in this
Notice and Questionnaire in its answers to Items 1 through 9 and the inclusion of such information in the Resale Registration Statement
and the related prospectus. The Selling Securityholder understands that such information will be relied upon by the Borrower in connection
with the preparation or amendment of the Resale Registration Statement and the related prospectus.
Once this Notice
and Questionnaire is executed by the undersigned beneficial owner and received by the Company, the terms of this Notice and Questionnaire,
and the representations and warranties contained herein, shall be binding on, shall inure to the benefit of and shall be enforceable
by the respective successors, heirs, personal representatives and assigns of the Company and the undersigned beneficial owner. This Notice
and Questionnaire shall be governed, adjudicated and enforced in accordance with terms of the Second Registration Rights Agreement.
[Remainder
of Page Intentionally Left Blank; Signature Pages Follows]
The Selling Securityholder
has caused this Notice and Questionnaire to be executed and delivered either in person or by its duly authorized agent.
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PLEASE RETURN THE
COMPLETED AND EXECUTED NOTICE
AND QUESTIONNAIRE
TO CENTOGENE N.V. AT:
Centogene N.V.
Am Strande 7
18055 Rostock, Germany
Attention: Chief
Financial Officer
Email: [***]
This Notice and
Questionnaire must be returned in the manner and within the time period set forth in the Second Registration Rights Agreement in order
to include Registrable Securities in such Registration Statement.
Exhibit 99.5
SUBORDINATION AGREEMENT
This Subordination Agreement
(the “Agreement”) is made as of October 26, 2023, by and between PHARMACEUTICAL INVESTMENT COMPANY, a closed joint
stock company incorporated pursuant to the laws of the Kingdom of Saudi Arabia, with commercial registration number 1010698585, having
its registered address located at Alra’idah Digital City, Building MU04, Al Nakhil District, P.O. Box 6847, Riyadh 11452, KSA (“Creditor”),
and OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria,
Virginia 22314, in its capacity as Collateral Agent (as hereinafter defined) for the Lenders (as hereinafter defined).
Recitals
A. Pursuant
to a Loan and Security Agreement (such agreement as it may be amended from time to time, the “Loan Agreement”), dated
as of January 31, 2022, among OXFORD FINANCE LLC (in its capacity as Collateral Agent for the Lenders, the “Collateral Agent”),
the Lenders from time to time a party thereto, including, without limitation, Oxford Finance LLC (the “Lenders”), CENTOGENE
N.V., a public limited liability company (naamloze vennootschap) incorporated under the laws of the Netherlands, having its corporate
seat (statutaire zetel) in Amsterdam, the Netherlands and with offices located at Am Strande 7, 18055 Rostock, Germany and registered
with the Chamber of Commerce (Kamer van Koophandel) under number 72822872 (“Parent”), CENTOGENE GMBH, a company
with limited liability (Gesellschaft mit beschränkter Haftung) incorporated under the laws of Germany with offices located
at Am Strande 7, 18055 Rostock, Germany, and registered with the commercial register (Handelsregister) of the local court (Amtsgericht)
of Rostock under HRB 14967 (“Centogene Germany”), CENTOSAFE B.V., a private limited liability company (besloten
vennootschap) incorporated under the laws of the Netherlands, having its corporate seat (statutaire zetel) in Amsterdam, the
Netherlands and with offices located at Am Strande 7, 18055 Rostock, Germany and registered with the Chamber of Commerce (Kamer van
Koophandel) under number 80366120 (“Centosafe”) and CENTOGENE US, LLC, a Delaware limited liability company with
offices located at 99 Erie Street, Cambridge, MA 02139 (together with Parent, Centogene Germany and Centosafe, individually and collectively,
jointly and severally, “Borrower”) has requested and/or obtained certain loans or other credit accommodations from
the Lenders which are or may be from time to time secured by assets and property of Borrower.
B. Creditor
has extended loans or other credit accommodations to Borrower, and/or may extend loans or other credit accommodations to Borrower from
time to time.
C. In
order to induce the Lenders to extend credit to Borrower and, at any time or from time to time, at the Lenders’ option, to make
such further loans, extensions of credit, or other accommodations to or for the account of Borrower, or to purchase or extend credit upon
any instrument or writing in respect of which Borrower may be liable in any capacity, or to grant such renewals or extension of any such
loan, extension of credit, purchase, or other accommodation as the Lenders may deem advisable, Creditor is willing to subordinate: (i)
all of Borrower’s indebtedness and obligations to Creditor (including, without limitation, principal, premium (if any), interest,
fees, charges, expenses, costs, professional fees and expenses, and reimbursement obligations), and any dividends and/or distributions
or other payments pursuant to call, put or conversion features in connection with equity securities of Borrower issued to or held by Creditor,
whether presently existing or arising in the future (the “Subordinated Debt”) to all of Borrower’s indebtedness
and obligations to the Collateral Agent and/or the Lenders; and (ii) all of Creditor’s security interests, if any, to all security
interests in Borrower’s property in favor of the Collateral Agent and/or the Lenders.
NOW, THEREFORE, THE PARTIES AGREE AS FOLLOWS:
1. Creditor
hereby acknowledges and agrees that (i) Creditor does not have any lien on or security interest in any property of Borrower, whether now
owned or hereafter acquired, including, without limitation, the “Collateral” as defined in the Loan Agreement, (ii)
Borrower is prohibited from granting to the Creditor any lien on or security interest in any property of Borrower, whether now owned or
hereafter acquired, including, without limitation, the Collateral and (iii) the Creditor shall not take any lien on or security interest
in any property of
Borrower whether now owned or
hereafter acquired, including without limitation, the Collateral. In furtherance of the foregoing, Creditor hereby subordinates (to the
extent required pursuant to Section 15 below, this includes subordination (achterstelling) pursuant to section 3:277 of the Dutch
Civil Code) to the Collateral Agent and the Lenders any security interest or lien that Creditor may have in any property of Borrower,
including without limitation, the Collateral. Notwithstanding the respective dates of attachment or perfection of any security interest
of Creditor and the security interest of the Collateral Agent and the Lenders, the lien and security interest of the Collateral Agent
and the Lenders in the any property of Borrower, whether now owned or hereafter acquired, including, without limitation, the Collateral,
shall at all times be senior to the lien and security interest of Creditor (and to the extent required shall be deemed a change in ranking
(rangwisseling) in respect of any such lien and security interest in favor of the Collateral Agent and the Lenders for any assets
situated in the Netherlands).
2. All
Subordinated Debt is subordinated in right of payment to all obligations of Borrower to the Collateral Agent and the Lenders now existing
or hereafter arising, together with all costs of collecting such obligations (including attorneys’ fees), including, without limitation,
all interest accruing after the commencement by or against Borrower of any Insolvency Proceeding (as defined below), and all obligations
under the Loan Agreement (the “Senior Debt”); provided, however, in no event shall the aggregate principal amount of
the Term Loans (as defined in the Loan Agreement) (such amount, the “Senior Cap”) exceed $50,000,000 (or at any time
prior to an Insolvency Proceeding of Borrower or any of its material Subsidiaries, such larger amount with the prior written consent of
Creditor and from and after such Insolvency Proceeding such consent shall not be required). For the sake of clarity, the aggregate principal
amount of the Senior Debt shall not include interest, Lenders’ Expenses, the Prepayment Fee, the Final Payment, the payment under
the Success Fee Agreement (as such terms are defined in the Loan Agreement) or other amounts due to the Collateral Agent and the Lenders.
Notwithstanding the foregoing, the Collateral Agent and Lenders shall not be bound by the Senior Cap from and after the date that the
Loan (as defined in the PIC Loan Agreement (as defined herein) pursuant to that certain Loan Agreement dated on or about the date hereof
between Creditor and Centogene N.V. (as amended to the extent permitted by the terms of this Agreement, the “PIC Loan Agreement”)
is converted into equity securities of Centogene N.V. (or any successor or other person) in accordance with the terms of the PIC Loan
Agreement.
3. Creditor
will not demand or receive from Borrower (and Borrower will not pay to Creditor) all or any part of the Subordinated Debt, by way of payment,
prepayment, setoff, lawsuit or otherwise, nor will Creditor exercise any remedy with respect to the Subordinated Debt or any property
of Borrower, whether now owned or hereafter acquired, including, without limitation, the Collateral, nor will Creditor accelerate the
Subordinated Debt, or commence, or cause to commence, prosecute or participate in any administrative, legal or equitable action against
Borrower (any action, an “Enforcement Action”), until such time as (i) the Senior Debt is fully paid in cash, and (ii)
the Lenders have no commitment or obligation to lend any further funds to Borrower, and (iii) all financing agreements among the Collateral
Agent and the Lenders and Borrower are terminated. Nothing in the foregoing paragraph shall prohibit Creditor from converting all or any
part of the Subordinated Debt into equity securities of Borrower which do not have any call, put or other conversion features that would
obligate Borrower to pay any money (including the payment of any dividends or other distributions for so long as the Senior Debt remains
outstanding) or deliver any other securities or consideration to the holder, Creditor hereby agrees that Borrower may not declare, pay
or make such dividends, distributions or other payments to Creditor and Creditor shall not accept any such dividends, distributions or
other payments. Notwithstanding the foregoing, if there is an Event of Default under the Subordinated Debt, Creditor may commence Enforcement
Actions against Borrower at the expiration of the Maturity Default Standstill Period (as defined herein) unless the Collateral Agent (or
its agent) is pursuing diligently in good faith an Enforcement Action related to the Senior Debt or the Collateral, or is pursuing diligently
in good faith to vacate any stay on prohibiting an Enforcement Action related to the Senior Debt or the Collateral. “Maturity
Default Standstill Period” shall mean, the period of one hundred eighty (180) days commencing on the date on which Collateral
Agent receives a written notice from Creditor, identified as a “Standstill Notice”, that states an event of default has occurred
and is continuing under the Subordinated Debt, and that, as a consequence thereof, Creditor has declared all of the Subordinated Debt
to be immediately due and payable. The Maturity Default Standstill Period shall be tolled during the pendency of any Insolvency Proceeding
of Borrower or any of its material Subsidiaries. Any amounts received by Creditor from any Enforcement Action shall be delivered to Collateral
Agent pursuant to Section 4 below.
4. Creditor
shall hold in trust for the Collateral Agent and the Lenders and promptly deliver to the Collateral Agent in the form received (except
for endorsement or assignment by Creditor where required by the Collateral Agent), for application to the Senior Debt, any payment, distribution,
security or proceeds received by Creditor with respect to the Subordinated Debt other than in accordance with this Agreement.
5. In
the event of Borrower’s insolvency, reorganization or any case or proceeding under any local or international bankruptcy or insolvency
law or laws relating to the relief of debtors, including, without limitation, applicable laws in Germany and in the Netherlands (including
any procedure or step taken in bankruptcy (faillissement), suspension of payments (surseance van betaling), emergency procedure
(noodregeling) or any other procedure having the effect that the entity to which it applies loses the free management or ability
to dispose of its property (irrespective of whether that procedure is provisional or final; and dissolution (ontbinding) or any
other procedure having the effect that the entity to which it applies ceases to exist or any notice under section 36 of the Dutch Tax
Collection Act (Invorderingswet 1990) (irrespective of whether this notice is pursuant to section 60 of the Act on the Financing
of Social Insurances (Wet financiering sociale verzekeringen) and including any restructuring schemes, plans (akkoorden)
or similar) (each, an “Insolvency Proceeding”), (i) this Agreement shall remain in full force and effect, (ii) the
Collateral shall include, without limitation, all Collateral arising during or after any such Insolvency Proceeding, and (iii) the Collateral
Agent’s and the Lenders’ claims against Borrower and the estate of Borrower shall be paid in full before any payment is made
to Creditor.
6. Collateral
Agent will endeavor to provide Creditor with a copy of any written notice of an Event of Default that Collateral Agent provides to Borrower
within two business days after Collateral Agent provides such written notice to Borrower, provided, however, that the failure by Collateral
Agent to provide such notice shall not be a breach of this Agreement.
7. Until
the Senior Debt is fully paid in cash and Lenders’ arrangements to lend any funds to Borrower have been terminated, Creditor irrevocably
appoints the Collateral Agent as Creditor’s attorney-in-fact, and grants to the Collateral Agent a power of attorney with full power
of substitution, in the name of Creditor or in the name of the Collateral Agent and/or the Lenders, for the use and benefit of the Collateral
Agent and the Lenders, without notice to Creditor, to perform at the Collateral Agent’s option the following acts in any Insolvency
Proceeding involving Borrower:
(i) To
file the appropriate claim or claims in respect of the Subordinated Debt on behalf of Creditor if Creditor does not do so prior to 30
days before the expiration of the time to file claims in such Insolvency Proceeding and if the Collateral Agent elects, in its sole discretion,
to file such claim or claims; and
(ii) To
accept or reject any plan of reorganization or arrangement on behalf of Creditor and to otherwise vote Creditor’s claims in respect
of any Subordinated Debt in any manner that the Collateral Agent deems appropriate for the enforcement of its rights hereunder.
In addition to and without limiting
the foregoing: (x) until the Senior Debt is fully paid in cash and Lenders’ arrangements to lend any funds to Borrower have been
terminated, Creditor shall not commence, support, encourage, or join in any involuntary bankruptcy petition or similar action or proceeding
(including Insolvency Proceedings) against Borrower, and (y) if an Insolvency Proceeding occurs: (i) Creditor shall not assert, without
the prior written consent of Collateral Agent, any application, claim, complaint, motion, objection or argument in respect of the Collateral
in connection with any Insolvency Proceeding, including, without limitation, any application, claim, complaint, motion, objection or argument
seeking adequate protection, to invalidate or subordinate any lien on the Collateral, to surcharge Collateral, to borrow money and/or
encumber the Collateral, to convert or dismiss the Insolvency Proceeding, to appoint an examiner or trustee (or similar, including but
not limited to a bankruptcy trustee, administrator, restructuring expert or observer), or relief from the automatic stay in respect of
the Collateral, (ii) Collateral Agent may consent to the use of cash collateral on such terms and conditions and in such amounts as it
shall in good faith determine without seeking or obtaining the consent of Creditor as (if applicable) holder of an interest in the Collateral,
(iii) if use of cash collateral by Borrower is consented to by Collateral Agent, Creditor shall not oppose such use of cash collateral
for any reason, (iv) Creditor shall not object
to, or oppose, any sale, abandonment,
or other disposition of any assets comprising all or part of the Collateral, free and clear of security interests, liens and claims of
any party, including Creditor, under Section 363 of the United States Bankruptcy Code (or similar, including sections 3:250 ff. of the
Dutch Civil Code to the extent initiated or supported by the Collateral Agent), a plan of reorganization or liquidation, or otherwise,
for any reason if such action is supported by Collateral Agent and, if requested by Collateral Agent, Creditor shall affirmatively and
promptly consent to such sale or disposition of such assets, if Collateral Agent has consented to, or supports, such sale or disposition
of such assets, and (v) Creditor shall not file a proof of claim or vote on any chapter 11 plan (or similar, including any restructuring
plan pursuant to Title IV of the Dutch Bankruptcy Act (Wet homologatie onderands akkoord)) with respect to any claim of Creditor
that is secured, in whole or in part, by the Collateral.
8. Creditor
represents and warrants that Creditor has provided Collateral Agent with true and correct copies of all documents evidencing or relating
to the Subordinated Debt. Creditor shall ensure that the PIC Loan Agreement contains provisions that such agreement is subject to the
terms of this Agreement. By the execution of this Agreement, Creditor hereby authorizes the Collateral Agent and the Lenders to amend
any financing statements filed by Creditor against Borrower as follows: “In accordance with a certain Subordination Agreement by
and among the Secured Party, the Debtor and Oxford Finance LLC, in its capacity as Collateral Agent, the Secured Party has subordinated
any security interest or lien that Secured Party may have in any property of the Debtor to the security interest of Oxford Finance LLC
and the Lenders identified therein in all assets of the Debtor, notwithstanding the respective dates of attachment or perfection of the
security interest of the Secured Party and Oxford Finance LLC and the Lenders.”
9. Neither
Borrower nor the Creditor may amend the terms of any Subordinated Debt without the prior written consent of the Collateral Agent and the
Lenders if such amendment is adverse to Borrower or Lenders in any material respect, or could reasonably be expected to be adverse to
Borrower or Lenders in any material respect. Without limiting the foregoing, no amendment of the documents evidencing or relating to the
Subordinated Debt shall directly or indirectly modify the provisions of this Agreement in any manner which might terminate or impair the
subordination of the Subordinated Debt or the subordination of any security interest or lien that Creditor may have in any property of
Borrower. By way of example, such instruments shall not be amended to (i) increase the rate of interest with respect to the Subordinated
Debt, or (ii) accelerate the payment of the principal or interest or any other portion of the Subordinated Debt. The Collateral Agent
and the Lenders shall have the sole and exclusive right to restrict or permit, or approve or disapprove, the sale, transfer or other disposition
of any of the property or assets of Borrower, including, without limitation, the Collateral, except in accordance with the terms of the
Senior Debt. Upon written notice from the Collateral Agent of the Collateral Agent’s and the Lenders’ agreement to release
its lien on all or any portion of the Collateral in connection with the sale, transfer or other disposition thereof by the Collateral
Agent and the Lenders (or by Borrower with consent of the Collateral Agent and the Lenders), Creditor shall be deemed to have also, automatically
and simultaneously, released any lien or security interest on such Collateral, and Creditor shall upon written request by the Collateral
Agent, immediately take such action as shall be necessary or appropriate to evidence and confirm such release. All proceeds resulting
from any such sale, transfer or other disposition shall be applied first to the Senior Debt until payment in full thereof, with the balance,
if any, to the Subordinated Debt, or to any other entitled party. If Creditor fails to release any lien or security interest as required
hereunder, Creditor hereby appoints the Collateral Agent as attorney in fact for Creditor with full power of substitution to release Creditor’s
liens and security interests as provided hereunder. Such power of attorney being coupled with an interest shall be irrevocable.
10. All
necessary action on the part of the Creditor, its officers, directors, partners, members and shareholders, as applicable, necessary for
the authorization of this Agreement and the performance of all obligations of Creditor hereunder has been taken. This Agreement constitutes
the legal, valid and binding obligation of Creditor, enforceable against Creditor in accordance with its terms. The execution, delivery
and performance of and compliance with this Agreement by Creditor will not (i) result in any material violation or default of any term
of any of the Creditor’s charter, formation or other organizational documents (such as Articles or Certificate of Incorporation,
bylaws, partnership agreement, operating agreement, etc.) or (ii) violate any material applicable law, rule or regulation.
11. If,
at any time after payment in full of the Senior Debt any payments of the Senior Debt must be disgorged by the Collateral Agent or the
Lenders for any reason (including, without limitation, any Insolvency Proceeding), this Agreement and the relative rights and priorities
set forth herein shall be reinstated as to all such disgorged payments as though such payments had not been made and Creditor shall immediately
pay over to the Collateral Agent all payments received with respect to the Subordinated Debt to the extent that such payments would have
been prohibited hereunder. At any time and from time to time, without notice to Creditor, the Collateral Agent and the Lenders may take
such actions with respect to the Senior Debt as the Collateral Agent and the Lenders, in their sole discretion, may deem appropriate,
including, without limitation, terminating advances to Borrower, increasing the principal amount, extending the time of payment, increasing
applicable interest rates, renewing, compromising or otherwise amending the terms of any documents affecting the Senior Debt and any collateral
securing the Senior Debt, and enforcing or failing to enforce any rights against Borrower or any other person. No such action or inaction
shall impair or otherwise affect the Collateral Agent’s and the Lenders’ rights hereunder.
12. This
Agreement shall bind any successors or assignees of Creditor and shall benefit any successors or assigns of the Collateral Agent and the
Lenders. This Agreement shall remain effective until terminated in writing by the Collateral Agent. This Agreement is solely for the benefit
of Creditor and the Collateral Agent and the Lenders and not for the benefit of Borrower or any other party. Creditor further agrees that
if Borrower is in the process of refinancing any portion of the Senior Debt with a new lender, and if the Collateral Agent and/or the
Lenders makes a request of Creditor, Creditor shall agree to enter into a new subordination agreement with the new lender on substantially
the terms and conditions of this Agreement.
13. Creditor
hereby agrees to execute such documents and/or take such further action as the Collateral Agent and the Lenders may at any time or times
reasonably request in order to carry out the provisions and intent of this Agreement, including, without limitation, ratifications and
confirmations of this Agreement from time to time hereafter, as and when requested by the Collateral Agent.
14. This
Agreement may be executed in two or more counterparts, each of which shall be deemed an original and all of which together shall constitute
one instrument.
15. This
Agreement shall be governed by and construed in accordance with the laws of the State of New York, without giving effect to conflicts
of laws principles. Creditor and the Collateral Agent submit to the exclusive jurisdiction of the state and federal courts located in
New York, New York in any action, suit, or proceeding of any kind, against it which arises out of or by reason of this Agreement. CREDITOR
AND COLLATERAL AGENT WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT
OR ANY OF THE TRANSACTIONS CONTEMPLATED HEREIN.
16. This
Agreement represents the entire agreement with respect to the subject matter hereof, and supersedes all prior negotiations, agreements
and commitments. Creditor is not relying on any representations by the Collateral Agent, the Lenders or Borrower in entering into this
Agreement and Creditor has kept and will continue to keep itself fully apprised of the financial and other condition of Borrower. This
Agreement may be amended only by written instrument signed by Creditor and the Collateral Agent.
[Balance of Page Intentionally
Left Blank]
IN WITNESS WHEREOF, the undersigned
have executed this Agreement as of the date first above written.
OXFORD
FINANCE LLC, as
Collateral Agent
By:
/s/ Colette H. Featherly
Name: Colette
H. Featherly
Title: Senior
Vice President
[Signature Page to Subordination Agreement]
IN WITNESS WHEREOF, the undersigned
have executed this Agreement as of the date first above written.
CREDITOR:
PHARMACEUTICAL
INVESTMENT COMPANY
By: /s/
Ibrahim Abdulrahman I Aljuffali
Name: Dr
Ibrahim Abdulrahman I Aljuffali
Title: Chairman
[Signature Page to Subordination Agreement]
Each of the undersigned approves of the terms
of this Agreement.
BORROWER:
|
|
CENTOGENE N.V. |
|
By: |
/s/ Kim Stratton |
Name: |
Kim Stratton |
Title: |
Chief Executive Officer |
BORROWER: |
|
CENTOGENE GMBH |
|
By: |
/s/ Peter Andreas Bauer |
Name: |
Dr Peter Andreas Bauer |
Title: |
Managing Director (Geschäftsführer) |
CENTOGENE GMBH |
|
By: |
/s/ Michael Priebe |
Name: |
Michael Priebe |
Title: |
VP Finance |
BORROWER: |
|
CENTOSAFE B.V. |
|
By: |
/s/ Jose Miguel Coego Rios |
Name: |
Jose Miguel Coego Rios |
Title: |
CFO |
BORROWER: |
|
CENTOGENE US, LLC
|
|
By: |
/s/ Debashree Ganguly |
Name: |
Debashree Ganguly |
Title: |
Managing Officer |
[Signature Page to Subordination Agreement]
Exhibit 99.6
Execution Version
PHARMACEUTICAL
INVESTMENT COMPANY
Alra’idah
Digital City, Building MU04, Al Nakhil District
P.O. Box 6847, Riyadh
11452
The Kingdom of Saudi
Arabia
October 26, 2023
Re: Right of
First Offer Agreement
Ladies and Gentlemen:
This
right of first offer agreement (this “Agreement”) is entered into by and between Pharmaceutical Investment Company,
a closed joint stock company incorporated pursuant to the laws of the Kingdom of Saudi Arabia (together with its successors and/or permitted
assigns, “Lender”), DPE Deutschland II A GmbH & Co. KG (“DPE A”), a German limited partnership,
DPE Deutschland II B GmbH & Co. KG, a German limited partnership (“DPE B”; DPE A and DPE B collectively “DPE”),
Careventures Fund II S.C.Sp, a special limited partnership organized under the laws of Luxembourg (“Careventures”), TVM Life
Science Innovation I, L.P., a Canadian limited partnership organized under the laws of Quebec (“TVM I”) and TVM Life
Science Innovation II SCSp, a special limited partnership organized under the laws of Luxembourg (“TVM II”; TVM I
and TVM II collectively “TVM”), relating to certain rights, obligations and other matters set forth herein in connection
with Centogene N.V., a public company with limited liability (naamloze vennootschap) incorporated under the laws of the Netherlands
(“Borrower”) and Lender’s entry into that certain Loan Agreement, dated as of the date hereof, by and between
Borrower and Lender (as may be amended, restated, amended and restated, modified or supplemented in accordance with its terms from time
to time, the “Loan Agreement”), and is to be effective as of the Closing Date (as defined in the Loan Agreement).
Lender, DPE, Careventures and TVM are each referred to herein as a “Party” and collectively as the “Parties”.
1. Defined Terms.
(a) The following capitalized terms shall be defined herein as follows:
“Affiliate”
has the meaning set forth in Rule 144 of the Securities Act as in effect on the date hereof.
“Agreement”
has the meaning set forth in the preamble of this Agreement.
“Borrower”
has the meaning set forth in the preamble of this Agreement.
“Business
Day” means any day other than a Saturday, a Sunday or any day on which banking institutions in New York City, United States,
Riyadh, Saudi Arabia or Frankfurt am Main, Germany are authorized or required by Law or executive order to close or be closed.
“Capital
Shares” of any Person means any and all shares of, interests in, rights to purchase, warrants or options for, participations
in, or other equivalents of, in each case however designated, the equity of such Person, but excluding any debt securities convertible
into such equity.
“Careventures”
has the meaning set forth in the preamble of this Agreement.
“Common
Shares” means the common shares, par value €0.12 per share, of Borrower.
“Exchange
Act” means the U.S. Securities Exchange Act of 1934, as amended.
“Exercise
Notice” has the meaning set forth in Section 2(b).
“Exercise
Period” has the meaning set forth in Section 2(b).
“DPE”
has the meaning set forth in the preamble of this Agreement.
“Fundamental
Change” means any of the following events:
(a)
the acquisition by any party (or parties acting in concert) of Common Shares representing more than 50% of the voting power of all of
Borrower’s Common Shares;
(b)
the consummation of (i) any sale, lease or other transfer, in one transaction or a series of related transactions, of all or substantially
all of the assets of Borrower and its Subsidiaries, taken as a whole, to any Person; or (ii) any transaction or series of related transactions
in connection with which (whether by means of merger, demerger, consolidation, share exchange, business combination, reclassification,
recapitalization, acquisition, liquidation or otherwise), the result of which is Borrower’s shareholders prior to any transaction
described in clause (i) or (ii) cease to own more than 50% of all classes of common equity of Borrower or its successor
following any such transaction; or
(c)
Borrower’s shareholders approve any plan or proposal for the liquidation or dissolution of Borrower;
provided,
however, that a transaction or event described in clause (a) or (b) above will not be deemed to constitute a Fundamental
Change if the Specified Shareholders each continue, immediately after such transaction or event described in clause (a) or (b)
to be the direct or indirect “beneficial owner” (as defined below) of substantially the same number of Common Shares
of Borrower (or replacement equity interests in the surviving entity, acquirer, successor, or transferee, as applicable (or the parent
entity thereof)) as each “beneficially owned” as of the date hereof.
For
the purposes of this definition, whether a Person is a “beneficial owner,” and whether shares are “beneficially owned,”
will be determined in accordance with Rule 13d-3 under the Exchange Act.
“Governmental
Entity” means (a) any supranational, national, federal, state, provincial, municipal, local or foreign government, governmental
authority, regulatory or administrative agency, governmental commission, department, board, bureau, agency, instrumentality, any court,
tribunal, arbitrator, mediator or other governmental official, authority or instrumentality and (b) any entity to whom a Governmental
Entity has assigned or delegated any authority or oversight responsibilities, including any notified body accredited, designated, licensed,
authorized or approved to assess and certify the conformity of a medical device (including in vitro diagnostic medical device) with the
requirements of the In Vitro Diagnostic Medical Devices Directive 98/79/EC, the In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746,
and applicable harmonized standards.
“JAMS”
has the meaning set forth in Section 9.
“JAMS
Rules” has the meaning set forth in Section 9.
“Lender”
has the meaning set forth in the preamble of this Agreement.
“Law”
means any statute, law, ordinance, rule, regulation, code, approval, license, Permit or Order, in each case, of any Governmental Entity.
“Loan
Agreement” has the meaning set forth in the preamble of this Agreement.
“Party”
or “Parties” has the meaning set forth in the preamble of this Agreement.
“Person”
means an individual, corporation, partnership, limited liability company, joint venture, trust or unincorporated organization or a Governmental
Entity.
“Permitted
Transferee” means, with respect to any Proposed Transferor, any Affiliate of the Proposed Transferor, any investment fund,
account or other vehicle (other than any portfolio company) managed or controlled, directly or indirectly, by such Proposed Transferor
or any Affiliate of such Transferor, or any limited partner, member or stockholder of any of the foregoing.
“Proposed
Transferee” has the meaning set forth in Section 2(d).
“Proposed
Transferor” has the meaning set forth in Section 2(a).
“Representatives”
means with respect to any Person, such Person’s Affiliates and its and their respective directors, officers, employees, agents,
insurance providers, and legal and financial advisors.
“ROFO
Option” has the meaning set forth in Section 2(b).
“ROFO
Party” or “ROFO Parties” has the meaning set forth in Section 2(a).
“Securities
Act” means the U.S. Securities Act of 1933, as amended.
“Specified
Shareholder” means each of DPE, Careventures and TVM.
“Subsidiary”
means, with respect to any Person, (a) any corporation, association or other business entity (other than a partnership or limited liability
company) of which more than 50% of the total voting power of the Capital Shares entitled (without regard to the occurrence of any contingency,
but after giving effect to any voting agreement or shareholders’ agreement that effectively transfers voting power) to vote in
the election of directors, managers or trustees, as applicable, of such corporation, association or other business entity is owned or
controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of such Person; and (b) any partnership or
limited liability company where (i) more than 50% of the capital accounts, distribution rights, equity and voting interests, or of the
general and limited partnership interests, as applicable, of such partnership or limited liability company are owned or controlled, directly
or indirectly, by such Person or one or more of the other Subsidiaries of such Person, whether in the form of membership, general, special
or limited partnership or limited liability company interests or otherwise; and (ii) such Person or any one or more of the other Subsidiaries
of such Person is a controlling general partner of, or otherwise controls, such partnership or limited liability company.
“Transfer”
means any direct or indirect sale, transfer, hypothecation, assignment, gift, bequest or disposition by any other means, whether for
value or no value and whether voluntary or involuntary. The term “Transferred” shall have a correlative meaning.
“Transfer
Notice” has the meaning set forth in Section 2(a).
“Transfer
Shares” has the meaning set forth in Section 2(a).
“TVM”
has the meaning set forth in the preamble of this Agreement.
2. Right of First Offer.
(a) Following
the consummation of any Fundamental Change of Borrower, and for so long as Lender holds at least 10% of outstanding Common Shares of
Borrower, including, prior to conversion, on an as-converted basis, if any Specified Shareholder or its Affiliates (collectively, “ROFO
Parties” and each a “ROFO Party”) desires to Transfer, directly or indirectly, any Common Shares then held
by such ROFO Party (the “Transfer Shares” and such ROFO Party, the “Proposed Transferor”), to any
Person or Persons other than any Permitted Transferee, in a bona fide transaction or series of related transactions, then such Specified
Shareholder shall be required to give written notice (a “Transfer Notice”) to Lender, which shall set forth the price
per Common Share in cash at which the Proposed Transferor is willing to Transfer the Transfer Shares to Lender (the “Proposed
Transferor Price”). In the event a Specified Shareholder or its Affiliates proposes to Transfer Common Shares to a Permitted
Transferee, such Specified Shareholder shall cause the Permitted Transferee to sign a joinder to this Agreement in form and substance
reasonably acceptable to Lender.
(b) Upon
delivery of the Transfer Notice, Lender shall have an option (the “ROFO Option”) to (x) purchase all (but not less
than all) of the Transfer Shares at the Proposed Transferor Price, to be exercised by irrevocable written notice (the “Exercise
Notice”) to be delivered to the Proposed Transferor not later than 20 Business Days after the date of delivery of the Transfer
Notice (the “Exercise Period”), or (y) propose, by irrevocable written notice (the “Lender Price Notice”),
such notice to be delivered to the Proposed Transferor within the Exercise Period, a lower price per Common Share in cash at which Lender
is willing to purchase all (but not less than all) Transfer Shares (the “Lender Price”). If Lender delivers within
the Exercise Period a Lender Price Notice, the Proposed Transferor shall have the option, by written notice to Lender, not later than
45 days after delivery of the Lender Price Notice (the “Acceptance Period”) to accept the Lender Price (the “Lender
Price Acceptance Notice”).
(c) If
(A) Lender delivers an Exercise Notice to the Proposed Transferor within the Exercise Period, or (B) Lender delivers a Lender Price Notice
to the Proposed Transferor within the Exercise Period and the Proposed Transferor delivers to Lender a Lender Price Acceptance Notice
within the Acceptance Period, Lender and the Proposed Transferor shall enter, within 20 days after delivery of the Exercise Notice or
the Lender Price Acceptance Notice (as the case may be), into a binding sale and transfer agreement in respect of the Transfer Shares
on customary terms, such agreement providing for a purchase price equal to the Proposed Transferor Price (in case of (A) of this sentence)
or the Lender Price (in case of (B) of this sentence), in each case such price being payable in full in cash at closing of the Transfer,
and such agreement further providing for customary representations and warranties as to capacity, due authorization, enforceability,
and title to shares free and clear of liens and encumbrances, and no other representations or warranties (the “ROFO SPA Terms”),
and at such closing, and upon the payment in full of the applicable price to the Proposed Transferor, the Proposed Transferor shall be
required to Transfer the Transfer Shares to Lender free and clear of all liens and encumbrances, other than those arising under applicable
federal or state securities laws, and shall execute and deliver such additional documents as are reasonably necessary or appropriate
to consummate the closing and the purchase and sale of the Transfer Shares; the closing of the sale of the Transfer Shares by the Proposed
Transferor to Lender shall be held via electronic exchange of documents or at such other time and place as the Proposed Transferor and
Lender may agree (but shall in any event occur within 90 days after execution of the purchase agreement (which 90-day period shall be
extended to up to 365 days, as required, in order for the relevant parties to obtain any required approval of any Governmental Entity)).
(d) If
(x) Lender declines to exercise the ROFO Option in writing or (y) Lender fails to deliver an Exercise Notice or Lender Price Notice to
the Proposed Transferor within the Exercise Period, in each case, such decline to exercise or failure to deliver an Exercise Notice or
Lender Price Notice exercising Lender’s right of first offer shall result in the termination of the ROFO Option set out in this
Section
2 solely with respect to the Transfer Shares identified in such Transfer Notice, and the Proposed Transferor shall be entitled to
initiate a sale process with respect to the Transfer Shares, to be supported by the Borrower, and consummate the Transfer with respect
to all (but not less than all) of the Transfer Shares to any Person or Persons other than any Permitted Transferee (a “Proposed
Transferee”) at any price and terms; provided that the execution of the binding agreement on such Transfer with such
Person or Persons is entered into within 180 days following the expiration of the Exercise Period and the closing of the sale of the
Transfer Shares shall occur within 90 days after execution of such binding agreement (which 90-day period shall be extended up to 365
days, as required, in order for the relevant parties to obtain any required approvals of any Governmental Entity). If such agreement
is not entered into within such 180-day period for any reason or if such closing does not occur within such 90-day period (as extended,
if applicable), then the restrictions provided for in this Section 2 shall again become effective, and no Transfer of the Transfer
Shares may be made thereafter by the Proposed Transferor without again offering the same to Lender in accordance with this Section
2; provided, that, in the event the Proposed Transferor is again offering the Transfer Shares to Lender within such 180-day
period in accordance with this Section 2, the Exercise Period for any such subsequent offer of the Transfer Shares shall be a
period of 10 Business Days after the date of delivery of the revised Transfer Notice.
(e) If
Lender delivered to the Proposed Transferor within the Exercise Period a Lender Price Notice and the Proposed Transferor does not deliver
to Lender within the Acceptance Period a Lender Price Acceptance Notice, the Proposed Transferor shall be entitled to initiate a sale
process with respect to the Transfer Shares to be supported by the Borrower, and consummate the Transfer with respect to all (but not
less than all) of the Transfer Shares to any Person or Persons other than any Proposed Transferee at such terms as the Proposed Transferor
agrees with such third party; provided, that the execution of the binding agreement on such Transfer with such Person or Persons
is entered into within 180 days following the expiration of the Exercise Period and the closing of the sale of the Transfer Shares shall
occur within 90 days after execution of the binding agreement (which 90-day period shall be extended up to 365 days as required, in order
for the relevant parties to obtain any required approvals of any Governmental Entity); provided, however, that if the price
per Common Share offered by the Proposed Transferee (the “Third Party Price”) is below the Proposed Transferor Price
set out in the Transfer Notice, the Proposed Transferor shall deliver to Lender a written notice of the Third Party Price (the “Second
Offer Notice”) and shall only be entitled to consummate the Transfer to the Proposed Transferee if Lender does not deliver,
within 10 Business Days after delivery of the Second Offer Notice (the “Second Offer Period”), a written notice under
which it irrevocably accepts the Transfer to it at the Third Party Price (the “Second Offer Acceptance Notice”). If
Lender delivers to the Proposed Transferor, within the Second Offer Period a Second Offer Acceptance Notice, Lender and the Proposed
Transferor shall enter, within 20 days after delivery of the Second Offer Acceptance Notice, into a binding sale and transfer agreement
in respect of the Transfer Shares, such agreement providing for a purchase price equal to the Third Party Price and otherwise for the
ROFO SPA Terms and the further provisions of Section 2(c) shall apply mutatis mutandis.
3. Survival.
Each Party’s obligations and covenants made in this Agreement shall survive the execution and delivery of this Agreement.
4. Entire Agreement; Amendment; Waiver. This Agreement represents
the entire understanding and agreement between the Parties hereto with respect to the subject matter hereof. Nothing expressed or implied
in this Agreement is intended or shall be construed so as to grant or confer on any person, firm or corporation other than the Parties
hereto, any rights or privileges hereunder. This Agreement can be amended, supplemented or changed, and any provision hereof can be waived,
only by written instrument making specific reference to this Agreement signed by the Party against whom enforcement of any such amendment,
supplement, modification or waiver is sought. No action taken pursuant to this Agreement shall be deemed to constitute a waiver by the
Party taking such action of compliance with any agreement
contained
herein. The waiver by any Party hereto of a breach of any provision of this Agreement shall not operate or be construed as a further
or continuing waiver of such breach or as a waiver of any other or subsequent breach. No failure on the part of any Party to exercise,
and no delay in exercising, any right, power or remedy hereunder shall operate as a waiver thereof, nor shall any single or partial exercise
of such right, power or remedy by such Party preclude any other or further exercise thereof or the exercise of any other right, power
or remedy.
5. Assignability.
Neither this Agreement nor any right, remedy, obligation or liability arising hereunder or by reason hereof will be assignable by any
Party without the prior written consent of the other Parties; provided, however, that Lender may assign any of its rights,
remedies, obligations or liabilities arising under this Agreement to its Permitted Transferees, if (a) it assigns its position as lender
under the Loan Agreement and its Common Shares to such Permitted Transferees and (b) such Permitted Transferees sign a joinder to this
Agreement in form and substance reasonably acceptable to Lender.
6. Further Instruments and Acts. Each of the Parties to this Agreement
agrees to execute and deliver such further instruments and do such further acts as may be reasonably necessary or proper to more effectively
carry out the purposes of this Agreement.
7. Waiver of Jury Trial. EACH OF BORROWER AND LENDER IRREVOCABLY WAIVES
ANY AND ALL RIGHT TO TRIAL BY JURY WITH RESPECT TO ANY LEGAL PROCEEDING ARISING OUT OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT.
8. Governing Law. This Agreement will be governed by and construed
in accordance with the internal laws of the State of New York.
9. Arbitration. Each Party agrees that any dispute, difference, claim,
question or controversy arising out of or in connection with this Agreement, which is not amicably settled between the Parties hereto
within a period of one month from the date of the start of negotiations between the Parties, shall be finally resolved pursuant to arbitration
pursuant to the terms set forth in this Section 9. New York, NY will be the place of arbitration. Arbitration shall be governed
by Judicial Arbitration & Mediation Services (“JAMS”) and its JAMS Comprehensive Rules and Procedures (“JAMS
Rules”) in effect at the time the arbitration is commenced. A panel of three neutral arbitrators will be selected in accordance
with the JAMS Rules to conduct the arbitration. The arbitration shall be conducted in English. The arbitral award shall be final and
enforced in any court of competent jurisdiction by either Party. To the extent permissible by Law, the Parties hereby waive any right
to appeal the decision of the arbitration. The arbitral tribunal may award legal costs and expenses as it deems fit. The Parties hereby
acknowledge and agree that arbitrators may issue procedural orders and decide on interim measures/injunctions in the course of the arbitration.
The Parties hereunder agree that any one of them may request in aid of arbitration from any court of competent jurisdiction, injunctive
relief or other conservatory measures. The Parties hereto hereby agree that the fact of any arbitration hereunder, the content of any
such proceedings and the outcome thereof shall be treated as confidential and shall be held confidential by each Party and their respective
Representatives in accordance with Section 17.
10. Expenses. Each of the Parties shall bear all of its own costs and
expenses incurred in connection with transactions contemplated by this Agreement, including without limitation, legal and meeting expenses
and costs in connection with the preparation of this Agreement and any filing expenses with respect to this Agreement.
11. Counterparts.
This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including .pdf or any electronic
signature
complying
with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method and any counterpart so delivered shall
be deemed to have been duly and validly delivered and be valid and effective for all purposes.
12. Notices. All notices and other communications under this Agreement
shall be in writing and shall be deemed given (a) when delivered personally by hand (with written confirmation of receipt), (b) when
sent by e-mail (with written confirmation of transmission) or (c) one Business Day following the day sent by overnight courier (with
written confirmation of receipt), in each case at the following addresses and facsimile numbers (or to such other address or facsimile
number as a Party may have specified by notice given to the other Party pursuant to this provision):
If
to Lender:
c/o
Pharmaceutical Investment Company
Alra’idah
Digital City, Building MU04, Al Nakhil District,
P.O.
Box 6847, Riyadh 11452,
The
Kingdom of Saudi Arabia
Attn:
[***]
Email: [***]
with
a copy to (which shall not constitute notice):
Latham
& Watkins LLP
Al-Tatweer
Towers, 7th Floor, Tower 1
King
Fahad Highway, PO Box 17411
Riyadh
11484, Saudi Arabia
Attn: Ahmed el-Gaili, David Zaheer, and Gregory P. Rodgers
Email: Ahmed.el-Gaili@lw.com
david.zaheer@lw.com
Greg.Rodgers@lw.com
If
to DPE:
c/o
DPE Deutsche Private Equity Gesellschaft mbH
Ludwigstr. 7
80539
Munich, Germany
Attn:
[***]
Email:
[***]
with a copy to (which shall
not constitute notice):
Gütt Olk Feldhaus
Hackenstraße 5
80331 Munich, Germany
Attn: Kilian Helmreich
Email: kilian.helmreich@gof-partner.com
If
to Careventures:
c/o
Careventures Fund II S C Sp
42
44 avenue de la Gare
L
1610 Luxembourg
Attn: [***]
Email: [***]
If
to TVM:
c/o TVM Life Science Management GmbH
Ottostraße 4
80333 Munich, Germany
Attn: [***]
Email: [***]
13. Binding Effect. The provisions of this Agreement will be binding
upon and accrue to the benefit of the Parties hereto and their respective heirs, legal representatives, successors and permitted assigns.
14. No Third Party Beneficiaries. This Agreement is for the sole benefit
of the Parties hereto and their successors and permitted assigns and nothing expressed or referred to in this Agreement will be construed
to give any Person, other than the Parties to this Agreement and such permitted assigns, any legal or equitable right, remedy or claim
under or with respect to this Agreement or any provision of this Agreement, whether as third party beneficiary or otherwise.
15. Severability. If any term or provision of this Agreement is invalid,
illegal or unenforceable in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other term or provision
of this Agreement or invalidate or render unenforceable such term or provision in any other jurisdiction.
16. Interpretation. Any reference to a contract, instrument or other
document as of a given date means the contract, instrument or other document as amended, supplemented and modified from time to time
through such date. The headings contained in this Agreement are for convenience of reference only and will not affect the meaning or
interpretation of this Agreement. All preamble, recital, article, section, exhibit and schedule references are to the preambles, recitals,
articles, sections, exhibits and schedules of this Agreement, unless otherwise specified. All references in this Agreement to “dollars”
or “$” are to U.S. dollars. All payments to be made in cash under this Agreement are to be paid in U.S. dollars. All references
in this Agreement to any period of days will mean the relevant number of calendar days, unless otherwise specified. When calculating
the period of time before which, within which or following which, any act is to be done or step taken pursuant to this Agreement, the
date that is the reference date in calculating such period will be excluded. If the last day of any period is a non-Business Day, the
period in question will end on the next succeeding Business Day. Words in the singular will be held to include the plural and vice versa.
Words of one gender will be held to include the other genders and neutral as the context requires. The terms “hereof,” “herein,”
“hereunder,” “hereto” and “herewith” and words of similar import will, unless otherwise specified,
be construed to refer to this Agreement and not to any particular provision of this Agreement. The word “including” and words
of similar import when used in this Agreement will mean “including, without limitation,” unless otherwise specified. The
word “or” will not be exclusive. The Parties acknowledge and agree that each has negotiated and reviewed the terms of this
Agreement, assisted by such legal and tax counsel as they desired, and has contributed to its revisions. The Parties further agree that
the rule of construction that any ambiguities are resolved against the drafting Party will be subordinated to the principle that the
terms and provisions of this Agreement will be construed fairly as to all Parties and not in favor of or against any Party.
17. Confidentiality. No Party hereto nor any of its Representatives
may make any press release or other public disclosure regarding the existence of this Agreement, its contents, or the transactions contemplated
by this Agreement without the written consent of the other Parties, in any case, as to the form, content, and timing and manner of distribution
or publication of such press release or other public disclosure (which consent may not be unreasonably withheld, conditioned, or delayed).
Each Party shall hold confidential the terms and provisions of this Agreement and the terms of the transactions contemplated by this
Agreement. Notwithstanding the foregoing, nothing in this Section 17 will prevent any Party or its Representatives from making
any press release or other disclosure (a) required by Law or the rules of any stock exchange, in which case the Party required to make
such press release or other disclosure shall use commercially reasonable efforts to allow the other Parties reasonable time to review
and comment on such release or disclosure in advance of its issuance or (b) to the accountants, Representatives, stockholders, members
and partners of such Party and its Affiliates or actual or potential acquirers of the disclosing Party’s interest in the Borrower,
each as necessary in connection with the ordinary conduct of their businesses (so long as such Persons agree to keep the terms of this
Agreement confidential).
[Signature Page
Follows]
The undersigned
hereby execute and deliver this Agreement as of the date first set forth above.
|
Lender: |
|
|
|
PHARMACEUTICAL INVESTMENT COMPANY |
|
|
|
By: |
/s/ Ibrahim Abdulrahman I Aljuffali |
|
|
Name: Dr. Ibrahim Abdulrahman I Aljuffali |
|
|
Title: Chairman |
Signature Page to ROFO Agreement
|
Specified Shareholders: |
|
|
|
DPE DEUTSCHLAND II A GMBH
& CO. KG, represented by: DPE DEUTSCHE PRIVATE EQUITY GESELLSCHAFT MBH |
|
|
|
By: |
/s/ Guido Prehn |
|
|
Name: Guido Prehn |
|
|
Title: MD |
|
DPE DEUTSCHLAND II B GMBH
& CO. KG, represented by: DPE DEUTSCHE PRIVATE EQUITY GESELLSCHAFT MBH: |
|
|
|
By: |
/s/ Guido Prehn |
|
|
Name: Guido Prehn |
|
|
Title: MD |
|
CAREVENTURES FUND II S.C.SP |
|
|
|
By: |
/s/ Eric Souetre |
|
|
Name: Eric Souetre |
|
|
Title: Director |
|
TVM LIFE SCIENCE INNOVATION I, L.P. |
|
|
|
By: |
/s/ Anthony Gausi |
|
|
Name: Anthony Gausi |
|
|
Title: Director of TVM LSI I(GP) Limited |
|
TVM LIFE SCIENCE INNOVATION II SCSP |
|
|
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By: |
/s/ Jens Hoellermann |
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Name: Jens Hoellermann |
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Title: Manager/Gérant |
|
TVM LIFE SCIENCE INNOVATION II SCSP |
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|
|
By: |
/s/ Karen McSorley |
|
|
Name: Karen McSorley |
|
|
Title: Authorised Signatory |
Signature Page to ROFO Agreement
Centogene NV (NASDAQ:CNTG)
過去 株価チャート
から 8 2024 まで 9 2024
Centogene NV (NASDAQ:CNTG)
過去 株価チャート
から 9 2023 まで 9 2024