RNS Number:1280U
Amersham PLC
12 January 2004



                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1)           Name of company

Amersham plc


2)           Name of shareholder having a major interest

Merrill Lynch & Co Inc and its direct and indirect subsidiaries


3)           Please state whether notification indicates that it is in respect
of holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18

Non-Beneficial interest


4)           Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

Merrill Lynch & Co Inc and its direct and indirect subsidiaries


5)           Number of shares/amount of stock acquired

Not advised


6)           Percentage of issued class

N/A


7)           Number of shares/amount of stock disposed

N/A


8)           Percentage of issued class

N/A


9)           Class of security

Ordinary shares of 5 pence each


10)       Date of transaction

Not advised


11)       Date company informed

7 January 2004


12)       Total holding following this notification

34,196,620





13)       Total percentage holding of issued class following this notification

4.85%


14)       Any additional information

N/A


15)       Name of contact and telephone number for queries

Susan Henderson, Deputy Company Secretary Tel 01494 542063


16)       Name and signature of authorised company official responsible for
making this notification

Susan M Henderson,



Date of notification 12 January 2004


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