As filed with the Securities and Exchange Commission on August 6, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
exellogo201709a04a.jpg
EXELIXIS, INC.
(Exact name of registrant as specified in its charter)

Delaware04-3257395
(State or other jurisdiction of incorporation or organization)(I.R.S. Employer Identification Number)
1851 Harbor Bay Parkway
Alameda, CA 94502
(Address of Principal Executive Offices, including Zip Code)
EXELIXIS, INC. 2000 EMPLOYEE STOCK PURCHASE PLAN
(Full Title of the Plan)
Michael M. Morrissey
President and Chief Executive Officer
Exelixis, Inc.
1851 Harbor Bay Parkway
Alameda, CA 94502
(650) 837-7000
(Name, Address, and Telephone Number, including Area Code, of Agent for Service)
Copies to:
Jeffrey J. HessekielRaquel Fox
Executive Vice President, General Counsel and SecretarySkadden, Arps, Slate, Meagher & Flom LLP
Exelixis, Inc.1440 New York Ave NW
1851 Harbor Bay Parkway
Washington, DC 20005
Alameda, CA 94502
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filerýAccelerated filer
¨
Non-accelerated filer
¨
Smaller reporting company
¨
Emerging growth company
¨
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨


EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Exelixis, Inc. (the “Company”) for the purpose of registering an additional 6,000,000 shares of common stock, par value of $0.001 per share (the “Common Stock”) to be issued pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan (as amended and restated, the “ESPP”). This Registration Statement relates solely to the registration of additional securities of the same class as other securities for which registration statements on Form S-8 relating to the ESPP set forth herein are effective.
Pursuant to General Instruction E to Form S-8, the contents of the prior Registration Statements on Form S-8 relating to the ESPP (File Nos. 333-35862, 333-57026, 333-82722, 333-102770, 333-113472, 333-124536, 333-133237, 333-147063, 333-159280 and 333-212866 previously filed with the Securities and Exchange Commission (the “Commission”) on April 28, 2000, March 14, 2001, February 14, 2002, January 28, 2003, March 10, 2004, May 2, 2005, April 12, 2006, October 31, 2007, May 15, 2009 and August 3, 2016, respectively, and Post-Effective Amendment No. 1 to certain of such Registration Statements on Form S-8 filed with the Commission on September 2, 2011 (collectively, the “Prior Registration Statements”)) are incorporated herein by reference in this Registration Statement, except as further supplemented by the information set forth below.
PART I
INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS*
*Information required by Part I to be contained in the Section 10(a) prospectus is omitted from this Registration Statement in accordance with Rule 428(b)(1) under the Securities Act of 1933, as amended (the “Securities Act”). The documents containing the information specified in Part I have been or will be delivered to the participants in the ESPP as required by Rule 428(b) and are not being filed with the Commission as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.


PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE
The following documents filed by the Company with the Commission are incorporated by reference into this Registration Statement:1
•The Company’s Annual Report on Form 10-K for the fiscal year ended December 29, 2023 (the “Form 10-K”), filed on February 6, 2024;
•The Company’s Quarterly Report on Form 10-Q for the fiscal quarter ended March 29, 2024, filed on April 30, 2024;
•The Company's Quarterly Report on Form 10-Q for the fiscal quarter ended June 28, 2024, filed on August 6, 2024;
•The Company’s Current Reports on Form 8-K filed on January 8, 2024 (but not including any Item 2.02 and Exhibit 99.1 of such filing, which were furnished under applicable Commission rules rather than filed), March 29, 2024, May 10, 2024, May 20, 2024, June 3, 2024 and August 6, 2024 (but not including any Item 2.02 and Exhibit 99.1 of such filing, which were furnished under applicable Commission rules rather than filed); and
•The description of the Company’s common stock that is contained in the Company’s Registration Statement on Form 8-A (File No. 000-30235), filed with the Commission on April 6, 2000, pursuant to Section 12 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), including any amendment or report filed for the purpose of updating such description, including Exhibit 4.2 to the Form 10-K.
All reports and other documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this Registration Statement and prior to the filing of a post-effective amendment that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Notwithstanding the foregoing, unless specifically stated to the contrary, none of the information that the Company discloses under Items 2.02 or 7.01 of any Current Report on Form 8-K that it may from time to time furnish to the Commission will be incorporated by reference into, or otherwise included in, this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein, or in any other subsequently filed document that also is or is deemed to be incorporated by reference herein, modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

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ITEM 8. EXHIBITS
4

SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Alameda, State of California, on August 6, 2024.
EXELIXIS, INC.
By:
/s/ Michael M. Morrissey
Michael M. Morrissey, Ph. D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints MICHAEL M. MORRISSEY, CHRISTOPHER J. SENNER and JEFFREY J. HESSEKIEL, and each or any one of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

Signature  Title Date
/s/ Michael M. Morrissey  Director, President and August 6, 2024
Michael M. Morrissey, Ph.D.Chief Executive Officer (Principal Executive Officer)
/s/ Christopher J. Senner  Executive Vice President and  August 6, 2024
Christopher J. Senner
Chief Financial Officer
(Principal Financial and Accounting Officer)
/s/ Stelios Papadopoulos  Chairman of the Board August 6, 2024
Stelios Papadopoulos, Ph.D.
/s/ Mary C. Beckerle  Director August 6, 2024
Mary C. Beckerle, Ph.D.
/s/ S. Gail Eckhardt  Director August 6, 2024
S. Gail Eckhardt, M.D.
/s/ Maria C. Freire  Director August 6, 2024
Maria C. Freire, Ph.D.
5

Signature  Title Date
/s/ Tomas J. Heyman  Director August 6, 2024
Tomas J. Heyman
/s/ David E. Johnson  Director August 6, 2024
David E. Johnson
/s/ Robert L. Oliver, Jr.  Director August 6, 2024
Robert L. Oliver, Jr.
 
/s/ George Poste  Director August 6, 2024
George Poste, DVM, Ph.D., FRS
/s/ Julie Anne Smith  Director August 6, 2024
Julie Anne Smith
/s/ Jack L. Wyszomierski  Director August 6, 2024
Jack L. Wyszomierski

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Exhibit 5.1 FIRM/AFFILIATE OFFICES ----------- BOSTON CHICAGO HOUSTON LOS ANGELES NEW YORK PALO ALTO WILMINGTON ----------- BEIJING BRUSSELS FRANKFURT HONG KONG LONDON MUNICH PARIS SÃO PAULO SEOUL SHANGHAI SINGAPORE TOKYO TORONTO SKADDEN, ARPS, SLATE, MEAGHER & FLOM LLP 1440 NEW YORK AVENUE, N.W. WASHINGTON, D.C. 20005-2111 ________ TEL: (202) 371-7000 FAX: (202) 393-5760 www.skadden.com August 6, 2024 Exelixis, Inc. 1851 Harbor Bay Parkway Alameda, California 94502 Re: Exelixis, Inc. Registration Statement on Form S-8 Ladies and Gentlemen: We have acted as special United States counsel to Exelixis, Inc., a Delaware corporation (the “Company”), in connection with the registration statement on Form S-8 (together with the exhibits thereto, the “Registration Statement”) to be filed on the date hereof by the Company with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933 (the “Securities Act”), relating to the registration of 6,000,000 shares (the “Shares”) of the Company’s common stock, par value $0.001 per share, available for future issuance under the Exelixis, Inc. 2000 Employee Stock Purchase Plan (as amended and restated, the “Plan”). This opinion is being furnished in accordance with the requirements of Item 601(b)(5) of Regulation S-K of the General Rules and Regulations of the Commission promulgated under the Securities Act (the “Rules and Regulations”).

 
Exelixis, Inc. August 6, 2024 Page 2 In rendering the opinion stated herein, we have examined the following: (a) the Registration Statement in the form to be filed with the Commission on the date hereof; (b) the Plan; (c) an executed copy of a certificate of Jeffrey J. Hessekiel, Executive Vice President, General Counsel and Secretary of the Company, dated the date hereof (the “Officer’s Certificate”); (d) a copy of the Company’s Restated Certificate of Incorporation, as in effect as of the date hereof (the “Certificate of Incorporation”), certified by the Secretary of State of the State of Delaware, and certified pursuant to the Officer’s Certificate; (e) a copy of the Company’s Amended and Restated Bylaws, as amended and in effect as of the date hereof (the “Bylaws”), and certified pursuant to the Officer’s Certificate; and (f) copies of certain resolutions of the Company’s Board of Directors (or a committee thereof), relating to the approval of the Plan, the filing of the Registration Statement and certain related matters, and certified pursuant to the Officer’s Certificate. We have also examined originals or copies, certified or otherwise identified to our satisfaction, of such records of the Company and such agreements, certificates and receipts of public officials, certificates of officers or other representatives of the Company and others, and such other documents as we have deemed necessary or appropriate as a basis for the opinion stated below, including the facts and conclusions set forth in the Officer’s Certificate. In our examination, we have assumed the genuineness of all signatures, including electronic signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as facsimile, electronic, certified or photocopied copies, and the authenticity of the originals of such copies. In making our examination of executed documents, we have assumed that the parties thereto, other than the Company, had the power, corporate or other, to enter into and perform all obligations thereunder and have also assumed the due authorization by all requisite action, corporate or other, and the execution and delivery by such parties of such documents and the validity and binding effect thereof on such parties. As to any facts relevant to the opinion stated herein that we did not independently establish or verify, we have relied upon statements and representations of officers and other representatives of the Company and others and of public officials, including the facts and conclusions set forth in the Officer’s Certificate.

 
Exelixis, Inc. August 6, 2024 Page 3 In rendering the opinion set forth below, we have also assumed that (i) the Shares will be issued in book-entry form and an appropriate account statement evidencing the Shares credited to a recipient’s account maintained with the Company’s transfer agent and registrar will be issued by the Company’s transfer agent and registrar, (ii) each award agreement under which options, stock appreciation rights, restricted stock, restricted stock units, stock bonuses, other stock-based awards and certain other awards are granted pursuant to the Plan will be consistent with the Plan and will be duly authorized, executed and delivered by the parties thereto, and (iii) the issuance of the Shares does not violate or conflict with any agreement or instrument binding on the Company (except that we do not and will not make this assumption with respect to the Certificate of Incorporation and the Bylaws). We do not express any opinion with respect to the laws of any jurisdiction other than the General Corporation Law of the State of Delaware (the “DGCL”). Based upon the foregoing and subject to the qualifications and assumptions stated herein, we are of the opinion that the Shares have been duly authorized by all requisite corporate action on the part of the Company under the DGCL and, when the Shares are issued to the Plan participants in accordance with the terms and conditions of the Plan and the applicable award agreement for consideration in an amount at least equal to the par value of such Shares, the Shares will be validly issued, fully paid and nonassessable. We hereby consent to the filing of this opinion with the Commission as an exhibit to the Registration Statement. In giving this consent, we do not thereby admit that we are included in the category of persons whose consent is required under Section 7 of the Securities Act or the Rules and Regulations. This opinion is expressed as of the date hereof unless otherwise expressly stated, and we disclaim any undertaking to advise you of any subsequent changes in the facts stated or assumed herein or of any subsequent changes in applicable laws. Very truly yours, /s/ Skadden, Arps, Slate, Meagher & Flom LLP RF

 

Exhibit 23.1
 

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2000 Employee Stock Purchase Plan of Exelixis, Inc. of our reports dated February 6, 2024, with respect to the consolidated financial statements of Exelixis, Inc. and the effectiveness of internal control over financial reporting of Exelixis, Inc. included in its Annual Report (Form 10-K) for the year ended December 29, 2023, filed with the Securities and Exchange Commission.

San Mateo, California
August 6, 2024


0000939767Exelixis IncS-8S-8EX-FILING FEESxbrli:sharesiso4217:USDxbrli:pure000093976712024-08-062024-08-0600009397672024-08-062024-08-06

Exhibit 107

CALCULATION OF REGISTRATION FEE

Security Type
Title of Securities
to be Registered
Fee Calculation Rule
Amount Being
Registered (1)
Proposed Maximum
Offering
Price per Unit
Proposed Maximum Aggregate
Offering Price
Fee Rate
Amount of
Registration Fee
EquityCommon Stock, $0.001 par value per shareRule 457(c) and (h) 6,000,000
$23.193(2)
$139,158,000(2)
0.00014760$20,540
Total Offering Amounts$139,158,000$20,540
Total Fees Previously Paid$0
Total Fee Offsets$0
Net Fee Due$20,540
(1)    This Registration Statement covers the offer and sale of 6,000,000 shares of Common Stock of Exelixis, Inc. (the “Registrant” or the “Company”) under the Exelixis, Inc. 2000 Employee Stock Purchase Plan (the “2000 Plan”). Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of the Registrant’s Common Stock that become issuable under the 2000 Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of outstanding shares of the Registrant’s Common Stock.
(2)    Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) under the Securities Act. The offering price per share and aggregate offering price are based upon the average of the high and low prices of the Registrant’s Common Stock on July 30, 2024, as reported on the Nasdaq Global Select Market.

v3.24.2.u1
Submission
Aug. 06, 2024
Submission [Line Items]  
Central Index Key 0000939767
Registrant Name Exelixis Inc
Form Type S-8
Submission Type S-8
Fee Exhibit Type EX-FILING FEES
v3.24.2.u1
Offerings - Offering: 1
Aug. 06, 2024
USD ($)
shares
Offering:  
Fee Previously Paid false
Other Rule true
Security Type Equity
Security Class Title Common Stock, $0.001 par value per share
Amount Registered | shares 6,000,000
Proposed Maximum Offering Price per Unit 23.193
Maximum Aggregate Offering Price $ 139,158,000
Fee Rate 0.01476%
Amount of Registration Fee $ 20,540
Offering Note
(1)    This Registration Statement covers the offer and sale of 6,000,000 shares of Common Stock of Exelixis, Inc. (the “Registrant” or the “Company”) under the Exelixis, Inc. 2000 Employee Stock Purchase Plan (the “2000 Plan”). Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of the Registrant’s Common Stock that become issuable under the 2000 Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of outstanding shares of the Registrant’s Common Stock.
(2)    Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) under the Securities Act. The offering price per share and aggregate offering price are based upon the average of the high and low prices of the Registrant’s Common Stock on July 30, 2024, as reported on the Nasdaq Global Select Market.
v3.24.2.u1
Fees Summary
Aug. 06, 2024
USD ($)
Fees Summary [Line Items]  
Total Offering $ 139,158,000
Previously Paid Amount 0
Total Fee Amount 20,540
Total Offset Amount 0
Net Fee $ 20,540
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