TIDMOBI
Ondine Biomedical Inc.
23 October 2023
23 October 2023
ONDINE BIOMEDICAL INC.
("Ondine Biomedical", "Ondine" or the "Company")
66.5% reduction in spine surgery infection rate
Pre-surgical Steriwave (R) nasal photodisinfection protocol
contributed to 66.5% reduction in spine surgery infection rates and
$2.5 million annual savings in Vancouver General Hospital
Canadian life sciences company, Ondine Biomedical Inc. (OBI:
LON), reports new independent research findings from Vancouver
General Hospital which were presented at the IP2023 conference in
Liverpool, England.
-- Canada's British Columbia-based hospitals, Vancouver General
& University of British Columbia (UBC) Hospitals, pioneered the
universal pre-surgical nasal photodisinfection and chlorhexidine
gluconate (CHG) wipes protocol and were the first hospitals to
adopt this approach as a standard of care, reducing post-surgical
infection rates without generating resistance.
-- 66.5% reduction in surgical site infection rate in spine
patients (7.98% vs 2.67%, p<0.001) despite rising anti-microbial
resistance.
-- $19.9 million net cost savings over the 8-year study period
between 2011 and 2019 from reduced infection rates.
-- Demonstration of long-term safety - no complications or
adverse events specific to the administration of nasal
photodisinfection.
With the inclusion of Steriwave nasal photodisinfection in its
presurgical quality improvement protocols, researchers at Vancouver
General Hospital (VGH) were able to demonstrate a 66.5% reduction
in its surgical site infection (SSI) rate in spine surgery
patients. The VGH spine group, led by Dr. John Street, presented
its research findings showing a significant and sustained reduction
of surgical site infections (SSIs) in spine surgery patients using
this universal pre-surgical protocol.
In collaboration with UBC Hospital, the new decolonization
protocol pioneered by the Vancouver Coastal Health Infection
Control team included Steriwave nasal photodisinfection alongside
skin cleansing with chlorhexidine gluconate (CHG) wipes to prevent
SSIs in patients undergoing major surgeries. As one of Canada's
largest tertiary hospitals, the VGH spine group also estimated that
the prevented SSIs over the 8-year study period between 2011-2019
resulted in institutional cost savings of $19.9 million, a net
annual cost saving of $2.49 million.
The poster, presented by Dr. Eryck Moskven, concludes that the
universal presurgical protocol involving nasal photodisinfection
and CHG skin decolonization "is a simple, safe, and clinically
effective preventative strategy for reducing the incidence of SSI
following emergent or elective spine surgery." Moreover, no
performance impact from resistance generation was observed during
the study period.
Surgical site infections are serious complications that can
occur following surgery. Spine SSIs can affect up to 18% of
patients who then require long, complex and costly treatment .
([1])
The full poster is available for viewing here .
**END**
Ondine Biomedical Inc.
+001 (604) 665
Carolyn Cross, CEO 0555
Singer Capital Markets (Nominated Adviser
and Joint Broker)
+44 (0)20 7496
Aubrey Powell, Asha Chotai, Sam Butcher 3000
RBC Capital Markets (Joint Broker)
+44 (0)20 7653
Rupert Walford, Kathryn Deegan 4000
Vane Percy & Roberts (Media Contact)
+44 (0)77 1000
Simon Vane Percy, Amanda Bernard 5910
About Ondine Biomedical Inc.
Ondine Biomedical Inc. is a Canadian headquartered company
innovating in the field of photodisinfection therapies. Ondine has
a pipeline of investigational products, based on its proprietary
photodisinfection platform, in various stages of development.
Products beyond nasal photodisinfection include therapies for a
variety of medical indications such as chronic sinusitis,
ventilator-associated pneumonia, burns, and other indications.
About Steriwave Nasal Photodisinfection
Nasal photodisinfection is a non-antibiotic method for nasal
decolonization that uses a proprietary light-activated agent
(photosensitizer) to destroy pathogens in minutes without causing
resistance . The photosensitizer is applied to each nostril using a
nasal swab, followed by illumination of the area with a specific
wavelength of red laser light for less than five minutes. The light
activates the photosensitizer, causing an oxidative burst that is
lethal to pathogens. In this single, 5-minute treatment, Steriwave
eliminates infection-causing bacteria, viruses, and fungi in the
nose - a major reservoir of pathogens. ([2])
Pre-operative nasal decolonization has been found to
significantly decrease SSIs caused by the infection-causing
pathogen S. aureus. ([3]) The Society for Healthcare Epidemiology
of America (SHEA) updated guidelines to elevate nasal
decolonization from a recommended practice to essential for
orthopaedic (including spine) and cardiothoracic surgical
procedures. ([4])
Rising rates of antimicrobial resistance are a serious concern:
the reported resistance rates for the antibiotic commonly used for
nasal decolonization, mupirocin, are as high as 81%. ([5]) SSIs
involving resistant pathogens are associated with significant
increases in the length of hospitalization and costs. ([6]) Unlike
currently used topical antibiotics, Steriwave can eradicate
pathogens including extensively drug-resistant (XDR) bacteria,
viruses (including coronaviruses), and fungi such as Candida auris.
([7])
Ondine's nasal photodisinfection system has a CE mark in Europe
and the UK and is approved in Canada and several other countries
under the name Steriwave(R). It has been used in Canada for over
ten years, with no serious adverse events reported. In the US, it
is currently undergoing clinical trials for regulatory
approval.
About the Photodisinfection Protocol used at Vancouver Coastal
Health:
Photodisinfection-based nasal decolonization therapy was first
introduced at Vancouver Coastal Health for universal pre-surgical
decolonization to reduce surgical site infections. In 2011, Dr.
Elizabeth Bryce, Regional Medical Director for Infection Control at
Vancouver Coastal Health Acute, led a multidisciplinary team
involving the Division of Medical Microbiology and Infection
Prevention, the Department of Orthopaedics and the Peri-operative
Care groups at Vancouver General Hospital and University of British
Columbia Hospital. The original Vancouver Coastal Health
decolonization team included:
-- Surgery: Bas Masri; Gary Redekop
-- Perioperative Services: Debbie Jeske; Claire Johnston; Kelly
Barr; Shelly Errico; Anna- Marie MacDonald; Tammy Thandi; Lorraine
Haas; Pauline Goundar; Lucia Allocca; Dawn Breedveld; Steve
Kabanuk
-- Infection Control: Elizabeth Bryce; Chandi Panditha; Leslie
Forrester; Diane Louke; Tracey Woznow
-- Medical Microbiology: Diane Roscoe; Titus Wong
-- Patient Safety: Linda Dempster
-- Quality Assurance, Training: Shelagh Weatherill
Having demonstrated significant patient safety outcomes and cost
savings with the first ever deployment of universal nasal
Photodisinfection, the VCH team received the 2013 Innovation Award
of Excellence from the International Conference for Prevention and
Infection Control (ICPIC), which is endorsed by the World Health
Organization.
[1] Chahoud J, Kanafani Z, Kanj SS. Surgical site infections
following spine surgery: eliminating the controversies in the
diagnosis. Front Med (Lausanne). 2014 Mar 24;1:7. doi:
10.3389/fmed.2014.00007.
[2] Liu Z, Norman G, Iheozor-Ejiofor Z, Wong JK, Crosbie EJ,
Wilson P. Nasal decontamination for the prevention of surgical site
infection in Staphylococcus aureus carriers. Cochrane Database Syst
Rev. 2017 May 18;5(5):CD012462. doi:
10.1002/14651858.CD012462.pub2. PMID: 28516472; PMCID:
PMC6481881.
[3] Lemaignen A, Armand-Lefevre L, Birgand G, et al.
Thirteen-year experience with universal Staphylococcus aureus nasal
decolonization prior to cardiac surgery: a quasi-experimental
study. J Hosp Infect. 2018;100(3):322-328.
doi:10.1016/j.jhin.2018.04.023 .
[4] Calderwood MS, Anderson DJ, Bratzler DW, et al. Strategies
to prevent surgical site infections in acute-care hospitals: 2022
Update. Infect Control Hosp Epidemiol. 2023;44(5):695-720.
doi:10.1017/ice.2023.67
[5] Poovelikunnel T, Gethin G, Humphreys H. Mupirocin
resistance: clinical implications and potential alternatives for
the eradication of MRSA. J Antimicrob Chemother.
2015;70(10):2681-2692. doi:10.1093/jac/dkv169
[6] Weigelt JA, Lipsky BA, Tabak YP, Derby KG, Kim M, Gupta V
(2010) Surgical site infections: causative pathogens and associated
outcomes. Am J Infect Control 38:112-120.
https://doi.org/10.1016/j.ajic.2009.06.010
[7] Ondine Biomedical Inc. (2023, September 14). Steriwave
proven highly effective against XDR bacteria [Press release].
https://www.londonstockexchange.com/news-article/OBI/steriwave-proven-effective-against-xdr-bacteria/16124940
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October 23, 2023 02:04 ET (06:04 GMT)
Ondine Biomedical (LSE:OBI)
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Ondine Biomedical (LSE:OBI)
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