Moleculin Biotech Inc (MBRX) 銘柄情報

MBRX...........................https://stockcharts.com/h-sc/ui?s=MBRX&p=W&b=5&g=0&id=p86431144783

Boom!

MBRX new 52 week low

MBRX new 52 week low

Not anymore;)
And btw…….an all time high is right around the corner ;)-

MBRX new 52 lo

MBRX new 52 lo

$MBRX NEWS https://twitter.com/BluePillarNews/status/1772224643430031780

MBRX: effective March 22,2024 a one for 15 reverse split:

https://hedgefollow.com/upcoming-stock-splits.php

The time has come. The rise of the Phoenix

MBRX.........................https://stockcharts.com/h-sc/ui?s=MBRX&p=W&b=5&g=0&id=p86431144783

Moleculin Announces New Positive Independent Report of No Cardiotoxicity in Annamycin

Source: PR Newswire (US)
– Annamycin continues to demonstrate no evidence of cardiotoxicity to date, now in a total of 62 subjects across three of the Company's Annamycin clinical trials

– Next generation anthracycline, Annamycin, has demonstrated both safety and promising early activity across multiple clinical studies with potential to be an effective treatment across multiple oncology indications

HOUSTON, Sept. 18, 2023 /PRNewswire/ -- Moleculin Biotech, Inc., (Nasdaq: MBRX) ("Moleculin" or the "Company"), a clinical stage pharmaceutical company with a growing pipeline, including Phase 2 clinical programs, for hard-to-treat tumors and viruses, today announced it has received a new independent assessment for the absence of cardiotoxicity in subjects treated with Annamycin. Data from the following subjects were made available to an expert in chemotherapy who is affiliated with a leading cancer research institute in assessing cardiotoxicity. After review of this data, the independent expert concluded that there was no evidence of cardiotoxicity:

Moleculin Biotech, Inc. is a clinical stage pharmaceutical company focused on the development of a broad portfolio of oncology drug candidates for the treatment of highly resistant tumors. (PRNewsfoto/Moleculin Biotech, Inc.)

The first cohort of 3 subjects (190 mg/m2) of its Phase 1B/2 clinical trial evaluating Annamycin in combination with Cytarabine (also known as "Ara-C" and for which the combination of Annamycin and Ara-C is referred to as AnnAraC) for the treatment of subjects with AML as both first line therapy and for subjects who are refractory to or relapsed after induction therapy (MB106). clinicaltrialsregister.eu: EudraCT 2020-005493-10 or clinicaltrials.gov: NCT05319587;
Cohort 4a (360 mg/m2) in the Phase 1B portion of the Company's ongoing U.S. Phase 1B/2 clinical trial evaluating Annamycin for the treatment of soft tissue sarcoma lung metastases (MB-107), comprised of 3 subjects. clinicaltrials.gov: NCT04887298; and
14 subjects in the Phase 2 expansion Recommended Phase 2 Dose (RP2D) (330 mg/m2) of the ongoing U.S. Phase 1B/2 MB-107 clinical trial.
This brings the total reviewed by an independent expert to 62 subjects covering 4 separate clinical trials in the U.S. and in Europe.
The data made available included left ventricular ejection fraction (LVEF) as determined by echocardiograms, ECHO strain imaging, and Troponin levels. "ECHO strain imaging" is a method in echocardiography (medical ultrasound) for measuring regional or global deformation (contraction or beating) of the myocardium (heart muscle). By strain rate imaging, the simultaneous function of different regions can be displayed and measured. Cardiac health biomarkers such as blood Troponin levels are considered an indicator of potential long-term heart damage.

"We continue to be encouraged by the potential of Annamycin, especially with the reports from this expert covering 62 subjects. This additional independent report of additional datasets provides further validation in the absence of cardiotoxicity," commented Walter Klemp, Chairman and Chief Executive Officer of Moleculin. "Annamycin continues to establish itself as a non-cardiotoxic anthracycline, even in subjects who have received far more than the lifetime maximum cumulative anthracycline exposure established by the FDA. In fact, 53 of the 62 subjects evaluated have been taken over the lifetime maximum of 450 mg/m2 and one of them as high as 3420 mg/m2. Our growing body of positive data for Annamycin continues to bolster our confidence in our belief that Annamycin is truly a 'next generation' anthracycline, especially in light of the growing efficacy data that we have previously reported in the treatment of STS lung mets and AML. We remain focused on advancing our Annamycin development programs and ultimately, addressing the medical unmet needs of people with difficult to treat cancers and viruses."

Annamycin is the Company's next-generation anthracycline that has been designed to be non-cardiotoxic (unlike currently prescribed anthracyclines) and has been shown in animal models to accumulate in the lungs at up to 30-fold the level of doxorubicin (a commonly prescribed anthracycline), as well as demonstrating the ability to avoid the multidrug resistance mechanisms that typically limit the efficacy of doxorubicin and other currently prescribed anthracyclines. Annamycin is currently in development for the treatment of STS lung metastases (STS lung mets) as well as both first line therapy and therapy for relapsed or refractory acute myeloid leukemia (AML), and the Company believes the drug may have the potential to treat additional indications.

About Moleculin Biotech, Inc.

Moleculin Biotech, Inc. is a clinical stage pharmaceutical company with a growing pipeline, including Phase 2 clinical programs, for hard-to-treat tumors and viruses. The Company's lead program, Annamycin is a next-generation anthracycline designed to avoid multidrug resistance mechanisms with little to no cardiotoxicity. Annamycin is currently in development for the treatment of relapsed or refractory acute myeloid leukemia (AML) and soft tissue sarcoma (STS) lung metastases.

Additionally, the Company is developing WP1066, an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other oncogenic transcription factors while also stimulating a natural immune response, targeting brain tumors, pancreatic and other cancers, and WP1220, an analog to WP1066, for the topical treatment of cutaneous T-cell lymphoma. Moleculin is also engaged in the development of a portfolio of antimetabolites, including WP1122 for the potential treatment of COVID-19 and other viruses, as well as cancer indications including brain tumors, pancreatic and other cancers.

For more information about the Company, please visit www.moleculin.com and connect on Twitter, LinkedIn and Facebook.

Forward-Looking Statements

Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Although Moleculin believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. Moleculin has attempted to identify forward-looking statements by terminology including 'believes,' 'estimates,' 'anticipates,' 'expects,' 'plans,' 'projects,' 'intends,' 'potential,' 'may,' 'could,' 'might,' 'will,' 'should,' 'approximately' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including those discussed under Item 1A. "Risk Factors" in our most recently filed Form 10-K filed with the Securities and Exchange Commission ("SEC") and updated from time to time in our Form 10-Q filings and in our other public filings with the SEC. Any forward-looking statements contained in this release speak only as of its date. We undertake no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events.

Investor Contact:

JTC Team, LLC
Jenene Thomas
(833) 475-8247
MBRX@jtcir.com

On September 14, 2023, Moleculin Biotech, Inc. (the “Company”), issued a press release which announced its abstract has been accepted for poster presentation at the 2023 CTOS Annual Meeting being held November 1-4, 2023 in Dublin, Ireland

Looks good here $$$$$

RS defeated.

We all have witnessed this stock with good news. Shoots up very fast with at least 1 mill shares traded. Wait til there is parabolic news, and 10’s of millions shares trade hands! It will shoot up to $10 easy.
I’ll wait for that ;) and it’s coming

$MBRX THIS IS GOOD >>---> As of December 31, 2022, we had cash and cash equivalents of $43.1 million and prepaid expenses and other current assets of $2.5 million. The Company believes that this cash is sufficient to meet its projected operating requirements into the third quarter of 2024.

https://dd7pmep5szm19.cloudfront.net/2705/0001437749-23-007580.htm

Recent Highlights




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Announced the publication of data evaluating Annamycin’s performance as an anthracycline designed to avoid the cardiotoxicity typically associated with currently prescribed anthracyclines, in a manuscript titled, "Anthracycline-induced cardiotoxicity – are we about to clear this hurdle?,” published in the peer-reviewed European Journal of Cancer.


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Received approval in Italy to conduct and dosed first subjects for Phase 1/2 trial evaluating Annamycin in combination with cytarabine (Ara-C) for the treatment of acute myeloid leukemia (AML).


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Announced final topline successful safety data – setting a recommended Phase 2 dose - and reported 80% overall response rate in final cohort from the European Phase 1 trial evaluating Annamycin as a single agent treatment of Refractory AML.


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Granted Fast Track Designation from the U.S. Food and Drug Administration (FDA) of WP1122 for the treatment of Glioblastoma Multiforme (GBM).





Summary of Financial Results for the Full Year 2022



Research and development (R&D) expense was $19.0 million and $14.4 million for the years ended December 31, 2022 and 2021, respectively. The increase in R&D of $4.6 million is mainly related to increased clinical trial activity, and costs related to manufacturing of additional drug product.



General and administrative (G&A) expense was $11.5 million and $8.4 million for the years ended December 31, 2022 and 2021, respectively. The increase in G&A of $3.1 million was mainly attributable to an increase in regulatory and legal services, and consulting & advisory fees.



The net loss for the year ended December 31, 2022 was $29.0 million, which included non-cash gains of $1.3 million on warrants in 2022 as compared to $6.7 million in the prior year and approximately $2.3 million of stock-based compensation expense in 2022 as compared to $2.4 million in 2021.



As of December 31, 2022, we had cash and cash equivalents of $43.1 million and prepaid expenses and other current assets of $2.5 million. The Company believes that this cash is sufficient to meet its projected operating requirements into the third quarter of 2024.

.75 walk down on air shares this morning

I wonder what really happened yesterday... would love to see a full 60 minute documentary on it

https://www.prnewswire.com/news-releases/moleculin-announces-presentation-of-positive-pharmacokinetics-and-tissue-organ-distribution-data-demonstrating-high-antitumor-activity-of-annamycin-in-preclinical-cancer-models-301800750.html

who TF just sold 50K shares @ .85 the bottom area

need to check their filings they must have a shelf offering or something

something is WRONG here

very wrong

MBRX BACK OVER .90 MAYBE $1+ IN AH...

THIS IS CRAZY, MANY ARE DOWN BIG

IF THEY DONT DILUTE, THIS COULD BOUNCE

#EVENTUALLY

This is crazy. Stock is trading for half of the daily high and for less than what it traded a month ago.

Moleculin Biotech, Inc. (MBRX) Upgraded to Buy: What Does It Mean for the Stock?
https://finance.yahoo.com/news/moleculin-biotech-inc-mbrx-upgraded-160004647.html

especially after it hit 1.63

At $1.02 a share I believe this is a huge buying opportunity.

Ok here we go!!!!

This is ready to explode any week!

* * $MBRX Video Chart 03-30-2021 * *

Link to Video - click here to watch the technical chart video

Nice gain today but well off the high.

Big week coming up!
Then HUGE MONTH!
Then MAMMOTH YEAR!!

I’m holding my shares in hopes but without news, seems to be stagnate.

I hear you Sphinx. I am invested in this as well. I am not sure about it exploding since this stock has disappointed time and time again. Throughout its history it has proven that its managers are too cheap to wisely invest in studies that can bear fruit. Instead they emphasize that the Polish subsidiary needs to pay them a royalty fee every year. Go figure!

I can’t believe that this message board has but a few people chatting.
This stock is about to double in one flash announcement that could come any day.
They also have other announcements to be handed out shortly after that one!!!!
I guess I’ll just sit here and chatter amongst the few and proud and relish in our own rewards.
Unbelievable

"Annamycin is a “next-generation” anthracycline that has recently been shown in animal models to accumulate in the lungs at up to 34 times the level of doxorubicin — which may account for the 100% survival rate attained in this most recent osteosarcoma lung metastases study."

The market is currently not pricing in the significance of these findings.

This looks to me to be severely under priced.

5.70!!!!!

Make it 5.18!!! Lol

Check that $5.15!!

$5.10!! News Eminent

It was there confirmation that they closed. Share offering @ 4.75 has been completed.

Prolly another R/S

I smell something great about to Happen!

Sold my shares and deleted from my watchlist

Offering at $4.75. Closes Friday. Time to load em up!!!! 10k at 4.71;) let’s go!

rinse, repeat

Not looking good today.

Selling off in AH trading. Down 1/2 of today's gain.

* * $MBRX Video Chart 02-02-2021 * *

Link to Video - click here to watch the technical chart video