MiNK Therapeutics Inc (INKT)

MiNK Therapeutics shares jump 80% after C-Further partnership announcementMarch 10, 2026 7:15 AM
IH Market News
MiNK Therapeutics (NASDAQ:INKT) shares climbed about 80% on Tuesday after the company revealed a collaboration with C-Further aimed at developing a PRAME-targeted iNKT cell therapy for pediatric cancers.Under the agreement, the clinical-stage biopharmaceutical company will receive around $1.1 million in non-dilutive funding to help support IND-enabling development of its PRAME-TCR-iNKT program. The deal also grants MiNK a double-digit percentage of any future commercial revenues generated by the therapy.The partnership will focus on advancing a T cell receptor-engineered invariant natural killer T cell therapy designed to target PRAME, a tumor-associated antigen found in several pediatric cancers, including sarcomas, acute myeloid leukemia and medulloblastoma. The initiative is among the first projects selected by C-Further, an international consortium dedicated to developing new pediatric oncology treatments.MiNK’s iNKT platform is built as an allogeneic, off-the-shelf treatment derived from healthy donors, allowing the therapy to be produced in advance and administered without the need for HLA matching or lymphodepleting chemotherapy. MiNK will act as the primary industry partner in the collaboration, while researchers at the University of Southampton will carry out preclinical studies to assess the therapy’s safety and anti-tumor activity across pediatric cancer models.The agreement is non-exclusive, enabling MiNK to continue progressing its iNKT platform independently in other cancer indications and partnerships. Funding under the collaboration will be released as specific scientific milestones are achieved, covering stages from preclinical candidate selection through translational development.C-Further is supported by Cancer Research Horizons, LifeArc and Great Ormond Street Hospital Charity, with a mission to accelerate the development of immunotherapies for children facing cancers with limited treatment options.MiNK Therapeutics stock price

Original: MiNK Therapeutics shares jump 80% after C-Further partnership announcement

Also, I don't see how target lesion reduction meets the formal criteria for a complete response by RECIST (1.1)? https://www.nature.com/articles/s41388-025-03491-0

Video: How #DDAmanda Found $INKT Early. +730%. Best Early Alert Stock Finder

#DDAmanda finds these before they run.



Z

Homerun King Of Nasdaq for 2025

$74 Market cap $300 million now from $30 million watch for that offering to hit is the name of the dilution game now 

N=1. One! I have not seen something like this just for a single case study for years!

Time to exit don't be greedy

She wants $150

Here is another example. People will pull in retail investors that try to make some money in life. Then these whales here will DUMP and we will be stuck holding the bag. Meanwhile the ones in the club get rich and we lose all the money we worked for for decades. My advice is stay away from these and don't take any advice from the mob club who never share any of their blessings with any of us. They just use that old tired line, do your DD, read, watch the money flow, yada yada. Problem with that is we are NOT PRIVY to that information since we are not part of their click.

Yep, there's $70 😃
This is a great ride. $70 is coming.
$INKT 💹

This is a great ride. $70 is coming.

$60+ 🤩 🚀

$INKT 💹

Awesome $50+ 🚀

$INKT 💹

MiNK Therapeutics Announces Publication of Complete Remission Following Allogeneic iNKT Cell Therapy in Metastatic Testicular Cancer

July 11, 2025

MiNK Therapeutics, Inc. (NASDAQ: INKT), a clinical-stage biopharmaceutical company pioneering allogeneic, off-the-shelf invariant natural killer T (iNKT) cell therapies, today announced the publication of another landmark case in Nature’s Oncogene describing a complete and durable remission in a patient with metastatic, treatment-refractory testicular cancer, following treatment with agenT-797, MiNK’s allogeneic iNKT cell therapy.

Complete remission after failure on platinum-based chemotherapy, autologous stem cell transplant, and multiple ICIs (anti–PD-1, anti–CTLA-4, and anti–TIGIT)

The publication, titled “Salvage therapy with allogeneic invariant natural killer T cells in a heavily pre-treated germ cell tumor,” presents a patient case from MiNK’s clinical trial (NCT05108623). The patient had progressed after multiple lines of therapy—including platinum-based chemotherapy, autologous stem cell transplant, and multiple immune checkpoint inhibitors (anti–PD-1, anti–CTLA-4, and anti–TIGIT)—and received a single infusion of agenT-797 alongside nivolumab. The patient achieved a complete clinical, radiologic, and biochemical remission, with no evidence of disease over two years later. Donor iNKT cells were detectable up to six months post-infusion, and treatment was well-tolerated with no cytokine release syndrome (CRS) or graft-versus-host disease (GVHD).

“This case exemplifies the powerful potential of iNKT cells in treating even the most challenging cancers,” said Dr. Benjamin Garmezy, Assistant Director of Genitourinary Research for Sarah Cannon Research Institute at SCRI Oncology Partners. “We observed a remarkable response in a patient who had exhausted standard and experimental treatments, offering compelling evidence to further pursue clinical studies of iNKT cell therapies in solid tumors.”

Durable Responses & Immune Activation in Solid Tumors with Allo-iNKT Therapy
These findings are part of a growing body of clinical evidence supporting the potential of agenT-797 in solid tumors. At the 2025 inaugural AACR Immuno-Oncology meeting, MiNK presented data from its Phase 2 trial in 2L gastric cancer, demonstrating immune activation, increased tumor infiltration, and early signals of tumor control in patients previously refractory to checkpoint inhibitors. Notably, extended survival beyond 12 months was observed in several patients—an outcome rarely seen in this setting. These clinical observations were further reinforced in a separate peer-reviewed case report published in Oncogene, which described a patient with metastatic gastric cancer who achieved a 42% tumor reduction and more than nine months of progression-free survival following a single infusion of agenT-797 in combination with nivolumab.

Together, these data highlight the potential of agenT-797 to reshape the tumor microenvironment and deliver durable clinical activity, even in heavily pretreated, immunotherapy-resistant cancers. The ongoing Phase 2 trial in gastric cancer (NCT06251973) is actively enrolling, with additional readouts expected in upcoming months. You can access the full publication here.

About MiNK Therapeutics
MiNK Therapeutics is a clinical-stage biopharmaceutical company advancing a new class of allogeneic invariant natural killer T (iNKT) cell therapies and precision-targeted immune technologies. MiNK’s proprietary platform is designed to restore immune balance and drive cytotoxic responses across cancer, immune-mediated diseases, and pulmonary immune failure. The company’s lead candidate, agenT-797, is an off-the-shelf, cryopreserved iNKT cell therapy currently in clinical development for graft-versus-host disease (GvHD), solid tumors, and severe pulmonary inflammation. MiNK is also advancing a pipeline of T cell receptor (TCR)-based therapies and neoantigen discovery tools that enable highly specific immune targeting across tumor and tissue types. With a scalable manufacturing process and a differentiated mechanism that bridges innate and adaptive immunity, MiNK is committed to delivering accessible, durable, and broadly applicable immune reconstitution therapies. For more information, visit www.minktherapeutics.com or follow us on X @MiNK_iNKT. Information important to investors is routinely posted to our website and social media channels.

About AgenT-797
AgenT-797 is an allogeneic invariant natural killer T (iNKT) cell therapy that harnesses the dual power of innate and adaptive immunity. iNKTs function as “master regulators,” combining the cytotoxic capabilities of NK cells with T-cell–like antigen recognition and memory. This unique biology enables a robust, pathogen-agnostic immune response that can be directed against hard-to-treat tumors.

Manufactured by MiNK Therapeutics in Lexington, MA, agenT-797 is a scalable, off-the-shelf product designed to provide accessible, transformative treatment options. In clinical trials, agenT-797 can bolster peripheral memory T-cell activation, enhance tumor infiltration, and potentially improve outcomes for patients with solid cancers (Cytryn et al., AACR IO 2024; Oncogene, 2024), as well as reduce inflammation in critically ill patients with severe respiratory pathology (Nature Communications, 2024).

https://ih.advfn.com/stock-market/NASDAQ/mink-therapeutics-INKT/stock-news/96413894/mink-therapeutics-announces-publication-of-complet

$INKT

Jen and Garo have run another company into the ground!

INTK.............................https://stockcharts.com/h-sc/ui?s=INTK&p=W&b=5&g=0&id=p86431144783

MiNK Therapeutics Announces $5.8 Million Private Placement and Appointment of Board Observer

INKT for swing Preclinical data is to be shared at AACR on April 8, 2024
Float 5m Insiders own 71.34% , had 9.68% 13D from 14/02/24 , No dilution

INKT under $2

Mink SITC 2022 posters are full of very exciting data! Here are some highlights.

1.Allogeneic unmodified iNKTs (agenT-797) show reductions in target and non-target lesions or disease stabilization in patients with solid
tumor cancers when administered alone [27%] and in combination with pembrolizumab (KEYTRUDA®) or nivolumab (OPDIVO®) [66%].
Phase 1 data show early signals of activity with disease stabilization in patients refractory to standard of care and those
who have progressed on KEYTRUDA or OPDIVO.
agenT-797 preferentially kills tumor-promoting M2 macrophages while preserving pro-inflammatory M1 macrophages
associated with anti-tumor responses.
agenT-797 can be dosed up to 1000x106
cells without lymphodepletion showing no signs of neurotoxicity and cytokine release syndrome (CRS grade ≥ 3).

2.Allo-iNKTs show signals of durable disease stabilization and modulation of M-spike protein seen in heavily pre-treated r/r multiple myeloma patients (2/8) after ≥6 prior lines of therapy.

3. agenT-797 shows 70% survival in severe viral ARDS compared to site reference controls (~10%); potential for a variant agnostic approach
to infections. In Phase 1/2 study, agenT-797 shows survival of 70% in mechanically ventilated patients compared to ~10% in a comparative case control population.

4. Increased 90-day survival in a subgroup of patients on respiratory bypass (ECMO) of 75% compared to 30% in a
comparative cohort with median survival of 119.5 vs 47 days.
agenT-797 demonstrates a favorable safety profile. Only 1 grade ≥3 treatment related adverse event and no CRS was
observed. agenT-797 treatment was associated with a reduction in secondary infections, including reduced incidence of pneumonia at
the highest dose level, a driver of ICU mortality.

5. MiNK’s FAP-CAR-iNKT therapeutic candidate, MiNK-215, demonstrates robust efficacy in non small cell lung cancer (NSCLC) preclinical
models, promoting curative responses, eliminating tumor burden in the lungs, and enhancing tumor specific CD8+ T cell infiltration
through tumor stroma.
FAP-CAR-iNKT demonstrates a drastic increase of CD8+ T cells infiltrating the tumor and significantly increased tumor
killing compared to T cells in murine models.
MiNK-215 shows robust preclinical efficacy towards tumor expressing FAP (FAP+ cancer model), underscoring potential to
target FAP+ tumors.

6. MiNK-413 is a differentiated allogeneic IL-15-armored-BCMA-CAR-iNKT therapeutic candidate, a next generation approach designed to
overcome the limitations of current autologous cell therapies.
MiNK-413 demonstrates superior tumor clearance in a systemic multiple myeloma models, compared to control BCMA-CAR.
Armoring MiNK-413 with soluble IL-15 enables prolonged persistence, which may translate to increased durability in patients.
MiNK-413 has the potential to target a broader population of patients with multiple myeloma.

7. MiNK’s proprietary CARDIS platform enables high-throughput rapid selection and optimization of functional CARs, like
MiNK-413 (IL-15-armored-BCMA-CAR-iNKT) and MiNK-215 (FAP-CAR-iNKT).

Allo-iNKTs (agenT-797) reinvigorate partially exhausted T cells and improve effector functions within the tumor microenvironment; critical
mechanisms in rescuing PD-1 refractory tumors.
In addition to their direct anti-tumor activity, allogeneic iNKT cells (agenT-797) improve immune effector function of immune
cells in the tumor microenvironment.
agenT-797 restores the cytotoxic capacity, activation, and cytokine production of partially exhausted T cells. agenT-797 preferentially kills tumor-promoting M2 macrophages while preserving pro-inflammatory M1 macrophages associated with anti-tumor responses.
agenT-797 activates dendritic cells, which can promote activation of T cells through enhanced antigen presentation.

The full poster presentations can be accessed on the publication section of MiNK’s website at https://minktherapeutics.com/publications/.

ARDS data will be important. BARDA support is a big deal.

Very interesting technology. Deserves a board.