Anavex Life Sciences Corporation (AVXL) オプション

By the time "compassionate use" arrives, we are post-trials.

Yes. For example, I don't think the published trial population has changed even though Missling has said it is increasing.

Given that no one outside the organization knows what it means, it's a pretty worthless quote. An analyst would be within bounds to ask Missling to explain it.

Total BS

I stand by my opinions. I don’t care what some fancy computer program says. My opinions are based on years of business management experience in biopharma. I’m the first to admit I could be wrong in the case of Anavex. In fact, I hope I’m wrong.

LOL

I did pitch shares at 8.47. Will g e t them back tomorrow. Thsnks to trump we will be making shoes and sowing dresses gor 2 dollars an hour yehah real mid class jobs. Are coming back.

What data they would get would be almost anecdotal. Too few people and entirely self selected. Not really meaningful to a regulator.

Just like i said i bought those mu calls and av c l shares. I hope you got in mu this morning.

Our clinical trial combined elements of both Phase 2 and Phase 3 stages of development. Full EMA approval is clearly the corporate strategy based on our Phase 2/3 trial plus OLE study.

This has been beaten to death in Jan of this year and yet few folks try to bring it up...for reasons that only they know...maybe cheap shares or protecting their call strategies....
Simply put, Anavex cannot comment on what various approval orgs across the world would say regarding next steps in the approval process for various CNS indications and hence "..Phase III and IV development...."

It is hilarious and also hurting to see these lame and desperate attempts....particularly to apply it to EMA process because they smell approval and are scared......

-vg_future

Thanks, Steady....I just now read your reply.....

So there is knowledge about who's getting the drug to that specific doctor yet he is under no obligation to mention the performance to some sort of official reporting/control person? Worse is that Anavex remains in the dark.

Agreed. Mgt need to clarify this asap. Otherwise they are giving shorts a gift to attack the company. Someone needs to call mgt.

It happened already. https://wsw.com/webcast/needham146/avxl/2275487

I tried since it does not seem to be up and up to me! Avanex is conducting a trial and just ships out product to the distributor who in turn passes that to the doctor who has no person checking on that person? Funny way to conduct a trial with results being most important....oh well

Chrismiss, we probably cannot put too much faith in that clinical trial record. CM told us months ago that Part B of the trial was being expanded to include more patients but the clinical trial record has not been updated for over 1 year (despite it being required by statute that Anavex keep it up-to-date.) My guess is that the trial will now end in July and maybe we get a top-line readout in August or September.

Is there a presentation tonight?

"...it seems likely that is what his remark referenced rather than the current MAA application."

"Seems likely" is why we need clarification.

It shouldn't be that difficult for the Anavex team to clarify for the shareholders.

So no more phone ringing—did his tinnitus get cured by Anavex 2-73? That will be another indication...

Anavex does not exist in a vacuum. The own goals by the current administration are a concern to all investors, including Anavex investors.

Considering that there are several P3 trials on the drug development list and that every approval has some form of P4 trial, it seems likely that is what his remark referenced rather than the current MAA application.

Anavex is learning what the regulators are concerned about in the MAA and that informs how future trials will be designed. Anavex will design the trials to answer those concerns to prevent questions at the application stage.

Take your mis-information crap to another board. This board is about Anavex.

That's the elephant in the room that no one is addressing.

Why did Dr. Juan Lopez-Talavera claim that our AD program sets the stage for a subsequent "strategy" of a Phase 3 and Phase 4 development plan? This definitely needs to be clarified.

"Additionally, the comprehensive data from the blarcamesine Alzheimer's disease program represents a solid foundation for the subsequent strategy of our Phase III and IV development plan".

Thank you, thank you. I designed dynamic websites for a living. And the Schwab site violates so many standard practices regarding load time computation (e.g., showing old data before displaying fresh data... the evils of dynamic javascript). I MISS my TD Ameritrade account. Loved how you'd mouse over a stock's link, such as AVXL or TSLA, and it would instantly pop up a chart of the last month. Still bummed that Schwab makes it so difficult to have fingertip access to meaningful data.

A3-71 will be approved and cross scripted by end of 2026.. good luck with a3-72..They were never gonna let this stop dementiaThey make too much money from us dying

It must be obvious to everyone that the general market decline has held down the Anavex share price. And there are certainly at least two government decisions that have been responsible for this situation.
The first was the appointment of a vaccine skeptic to head up health care. He inserted himself into a measles vaccine controversy in Samoa some years ago. His criticism of the measles vaccine lead to some deaths(do your own dd on this). Even now in Texas he supported the measles vaccine on one hand but also praised some local vaccine skeptics on the other. I have travelled the world many times and I am very glad we have scientifically tested vaccines! Polio and Measles vaccines are two examples of very safe and effective vaccines that have saved millions of lives! There are many problems with the FDA ....Mainly their deference to the BP's who fund it IMO! Clearly RFK jr's appointment was political (for dropping out of the Presidential race and backing the eventual winner in a very close race). Does his appointment affect the biotech sector and Anavex? Certainly!

But the government decision that has affected the general market the most is to initiate a Tariff War. In his first Presidency he did this for a short time with Canada and Mexico. Then he renegotiated NAFTA. At the time he said the new deal he negotiated was the best the world had ever seen! Lately he has attacked the deal he negotiated claiming is was very unfair to the US and Canada and Mexico were taking advantage, raping and pillaging the US! Does he not remember that he did the deal? Tariff wars make both sides loss. Look at how Smoot/Hawley deepened the Depression in 1930! US Tariffs are a tax paid by US consumers! They are inflationary. And world wide tariffs will cause worldwide inflation! No wonder stock markets around the world are tanking!
And does this affect the biotech sector and Anavex? Certainly!
Governments come and go. They do some good things and some bad things. But ANAVEX is doing nothing but good and will survive many governments!

That's a good question.

Despite fear mongering about the market, 2 facts:

S&P 500 is about where it was a year ago, before Fed money pump to inflate the market before the election

AVXL is about double what it was a year ago.

Tariffs not an issue with AVXL

Sad.

Thanks, F, ... maybe it's a glitch on my schwab.

AVXL Share Price Up Today
I have Schwab, and it's not factoring the day's close and update total for AVXL.
I have my AVXL shares with Schwab, and follow the share price by watching Schwab's watchlist, where I have AVXL listed.

I found no problems today.

Presently, Schwab shows AVXL with a close at $8.32. After hours, right now, the latest trade is listed at $8.33, a 1.71% gain today over yesterday.

The Dow-Jones was down 0.91% for the day.

Alive and “weak”? Haha! More like dead and buried. Let the man rest in peace already.

Is anyone having problems with their brokerage account not registering the AVXL day change.? I have Schwab, and it's not factoring the day's close and update total for AVXL. I've got schwab working on it.

When a patient signed up for a trial the drug was distributed via the trial Drs and maybe directly from the distributor via mail. Compassionate use could just continue that pathway.

I did look into how that worked in AU and there is a particular distributor that specializes in trial drugs and distribution. At the point of compassionate use the system knows who is getting the drug and how much and how often. That system can continue.

Kund
If I may, you hate this stock, post hourly about your hate, yet you listen to every presentation..
Your words, nothing new year after year, 10 + years...a marvelous life you have carved out for yourself

Groan.

As usual, when u expect anything with this stock, even with good news, there's a 90% chance u will be disappointed....NEVER EVER EXPECT

Wrong.
He discusses the Brain loss data, prophylactic use of Blarcamesine, meeting with other regulators discussing path forward, and the recent OLE data.

All in all a good presentation. He stumbled a bit in choosing words and still made his points clearly.

https://clinicaltrials.gov/study/NCT06245213?term=ANAVEX3-71&rank=2

Targeted end date: 5/15 🙌

I can't help on this one.

Next news should be about 3-71 results in the schizophrenia P2 trial (part B).

Good talk. OLE in presentation but otherwise nothing new.

What? No news about that Phase IV trial?

In a very stormy market Anavex is a gem!

No debt.

Cash for 4 years.

EMA blarcamesine Alzheimers approval expected 2025.

Applications in UK, Canada, Australia and Asia-Pacific in 2025.

Partnership(s) announcement due any time in 2025.

Anavex 3-71 phase 2b results mid 2025. (June ?)

Preparing for blarcamesine trials in Parkinsons and Fragile X.

Blarcamesine Alzheimers approval in Europe will stir up FDA talks!

Worldwide partnerships will make Anavex very cash rich!

Billions in upfront and milestones with very attractive royalties are expected in 2025! Investors will be looking for a dynamic safe harbor in stormy markets!

Steady T
I would think that any patient on the drug would have a script written and endorsed/verified by Avanex for that specific doctor participating in the trial; otherwise there might be people receiving the drug from that doctor and not authorized by Anavex....

Of course, I don't know how clinical trials are monitored by these distributors...or Anavex.

Something stinks with this process and does not seem legal to me...maybe someone like Boi would know?

Looks like he used my suggestion and used his tape from last month presentation, he only spoke when it was ole data slide. He is stretching his cash more by not speaking all the time.

IH Admin [Shelly]

Member Level
Re: None

Friday, April 04, 2025 2:21:42 PM

Post#
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I've been getting quite a few messages from Mods and Members re: political posts on stock specific boards.

The trajectory the current Administration has chosen has been creating havoc with the markets. This is understandably something that people want to discuss as it relates to their investments, trades and portfolios.

Some have argued that the political climate and fluctuations in the broader market don't play a part in OTCBB and penny stocks. However, others believe these absolutely impact every aspect of trading and investing.

Going forward, we are going to allow discussion of current political events on stock specific boards when they're impacting the market as a whole.
The messages that should be removed are ones where the Author is personalizing it, such as speculating about other Members political stance (i.e. "you're just a dumb MAGA/Lib").

I know this isn't welcome news to many people but there's simply no way to separate current political events from the markets these days.

I don't think that Anavex is sending pills to individuals. Anavex sends the drugs to a distributor that then fills the prescriptions from individual's Dr.

All Anavex knows is how many pills the distributor orders.

I'm ecstatic on ANY UP day!

Good talk. OLE in presentation but otherwise nothing new.

UP 14 whole pennies! Yippee!

Nice to see you cackling with JOY!