Anavex Life Sciences Corporation (AVXL)

Nice to see the AM action today.

Need to break through $2.80 and stay there to support the notion of a new uptrend!

Still nothing from these scammers? Pathetic

It may be the murines are really happy,,,

So what? Meaningless for Anavex.

Sigma-1 receptor agonist SA4503 improves cerebral protective effects in an extracorporeal cardiopulmonary resuscitation rat model

https://pmc.ncbi.nlm.nih.gov/articles/PMC13316324/

Good luck and GOD bless,

Yes

You’re welcome. And again, thank you for your patience.

That letter looks more professional than this for the past 8 weeks:

Thank you for the update Terrie.

I guess Miss Communication was brought in to run the stock into the dirt and then sell the company for peanuts.

The only thing that’s silly is all the nonsense (and worse) that has been spewed on this board for years. As for Anavex, I have been consistently right. I know how much that hurts.

The lack of communication from Anavex is a tell. Wouldn’t it be nice if they said something like this:

Dear stockholders,

Thank you for your patience during this period since I became interim CEO. For the past two months we and our consultants have undertaken a thorough review of all the data from every trial the company has done. At this time we are satisfied as to the integrity of our data. We believe Blarcamesine has shown itself to be both safe and efficacious and we are determined to move ahead with additional trials in Alzheimer’s disease as well as other indications.

Over the next several months we will be building a new team to ensure the integrity of our research and drive positive outcomes. Fortunately, our financial position is strong. We have the resources we need to conduct our research and clinical trials over the next several years. However, should we need additional capital, we are confident we can raise the funds we need through partnerships and/or from institutional biotech investors.

We believe the future of Anavex is bright. We are excited to start anew and build a world-class biotech company and rebuild credibility with our valued shareholders and partners.

Again, we thank you for your patience. We will do everything possible to enhance shareholder value, which is our primary responsibility.

Should you have any questions, please feel free to contact us through our investor relations firm. We will endeavor to respond to you as quickly and a fully as possible.

I look forward to speaking with you on a conference call in the not too distant future.

Best,

Silly response with all the time you spend here. As if you don’t have an agenda beyond saving shareholders. You’re fooling no one with any common sense.

It’s true. I do find this board entertaining. As for Anavex, I continue to believe nothing matters except a large, well designed and executed phase 3 trial in AD. Assuming Anavex is still around, which seems unlikely, and does the trial, which also seems unlikely, we may have an answer in the early 2030s. That gives me many years to continue to enjoy the entertainment.

Take care not to allow your hopes, fears, and greed to drive your investment decisions.

So what?

Sigma 1 Receptor Activation Coordinates Metabolic Stress Responses to Protect Retinal Vasculature in Ischemic Retinopathy

https://iovs.arvojournals.org/article.aspx?articleid=2817981

Good luck and GOD bless,

“ Anyway, none of it matters.”

Sure it matters. That’s why you are here “entertaining” yourself.

The Anavex fiasco is there for all to see. Distractions like how many shares are bought or posting the video of Ern for the millionth time no longer hold water. The pumping continues but his well has run dry.

Everybody (well almost everybody) finally realizes that Missling was a disaster waiting to happen and the stock price collapse was inevitable. It was just a matter of time. The only cabal at work was Missling and the board members.

In the unlikely event Anavex survives, it’ll take a well designed and executed Phase 3 trial to determine once and for all whether Blarcamesine is safe and effective. It’ll be 2030 or 2031 before we know. How many shares bought or sold every day is immaterial and a distraction. Posting the Ern video again and again smacks of delusion or desperation. Anyway, none of it matters.

Well you never know how many shares are purchased you only know how many are shared but you like to say bought, nobody really cares we're much more interested and not losing a penny today when the stock market is way up... as far as your prediction of 5 million shares bought today you only missed by 4.5 million but good try

What is the true value of Anavex? The market cap around 250 million, with perhaps 110 million or so in cash. But it has no products, and it has a burn rate for the expenses and the employees. Where are the massive layoffs? (everybody should be layed off immediately). So it should not even sell for 110 million market cap, not with no conceivable drug candidates and a burn rate of what, 10 million annually? Presuming it will take 3 years for the sole employee (hopefully) to go out and get an actual drug candidate for phase one clinical testing.........and all the expense and risks of clinical trials, it should sell for perhaps a 30 - million dollar market cap....Perhaps 30 or 40 cents, absolute max, The so called company, it is not actually a company should come out and tell the public that it is deep sixing this so called BlahBlah-casimine liquid, but the stock would go to its true value almost over night. And so you see, this is the Dream scenario of retail investors and the anon funds who just buy an index where AVXL might make up .05% of the composition. It is not even junk. At least Fred Sanford and his son "the dummie" made money as junk collectors. It is garbage, and only Tony soprano made money from garbage. insert-text-here

So, this is a MOC event?

Today is the end of June and the end of the 2nd calendar quarter financial institutions will be rebalancing there stock holdings.

Good luck and GOD bless,

On the basis of what. Not starting strong.

"Don't let Fear Uncertainty and Doubt" cloud your investment decision. Fixed it for you.

Yes, and enriching himself at the expense of shareholders in the process. What a guy.

Expect nearly 5 million shares of AVXL to be bought today!!!

Good luck and GOD bless,

You will get more efficacy from drinking coffee, then taking this drug. It’s over.  The company is another SAVA. Reputation is damaged and must start over from scratch. This was a failed cancer drug 15 years ago and it has failed at every other indication. Misleading was very good at getting you all to follow the shiny new object. 

No regulatory body will approved a drug that has not been shown to be safe and effective. The CHMP said there was no evidence of either. Your demand for approval is based on flawed data that was contorted to try to get the results that Missling wanted. Despite his best efforts at deception, the CHMP saw right through his scheme. Everyone wants better AD treatments. That is the goal. But to advocate so vociferously for a compound that had failed in the clinic only invites disappointment. If Anavex can actually survive long enough to a properly designed and executed phase 3 trial and prove safety and efficacy to the satisfaction of drug regulators then it should and will be approved. Until then, do not left fear, hope, and greed drive your investment decisions.

Again we can't actually know with any certainty how well Blarcamesine works because we still haven't see a well designed trial with conclusions that can be trusted.

Approve Blarcamesine! The best CNS drug invented to date. Hands down. No brain bleeding here in over 10 years of drug trial results. Sign me up for Amazon home delivery.. C'mon & hurry up.. Imo

"...Among these compounds, the most advanced clinical programs involve blarcamesine in Alzheimer’s disease and Rett syndrome, and pridopidine in Huntington’s disease and ALS These phase 2 and phase 3 trials have played a major role in increasing acceptance of s1 receptor-targeting therapies among clinicians and regulatory agencies....."

Written by Dr. Mauricee Tangui PhD

https://www.tandfonline.com/doi/full/10.1080/14728214.2026.2696872#d1e155

Good luck and GOD bless,

It tacked on another $0.95 between your post and the close.

An interesting pre-print published a few days ago examined individual neurons in the human entorhinal cortex—one of the first brain regions affected in Alzheimer's disease, where pathological changes often begin before much of the hippocampus. Using single-cell sequencing, the researchers analysed tens of thousands of brain cells and identified around 30 distinct subtypes of excitatory neurons. Each subtype had its own characteristic pattern of gene expression. One of these subtypes was labelled Exc ZNF385D COL24A1 (Supplementary Figure 3A), meaning that COL24A1 was one of the principal marker genes used to distinguish this neuronal population from the other excitatory neuron subtypes in the entorhinal cortex.

https://www.biorxiv.org/content/10.64898/2026.06.22.733753v1.full.pdf

Sigma 1 receptor agonists: the new trend or an emerging therapeutic option?

https://www.tandfonline.com/doi/full/10.1080/14728214.2026.2696872#references-Section1

Good luck and GOD bless,

Anavex needs something that it doesn’t have: A drug that works.

Her valuable insight was my first comment which is gained through experiences. Dr Kellmeyer has a career in exactly as you described but has been indirectly aware of parnerships, licensing, dissolving of partnerships, mergers, aquisitions and joint ventures. I have not followed her career but did know of her 17 years ago through Amylin Pharma, a glp-1 discovery company I was invested in. Amylin was on a roll, Symilin was their first FDA approval, they were added to the qqq's (nasdaq top 100 companies) at one point and Eli Lilly was their partner. They were working on a once weekly formula. Incredibly, Lilly decided to develop their own in house once weekly formula, the suits could not get along! Amylin had to legally sue Lilly to disolve the partnership and won. Amylin was eventually bought out through a BMY/AZN joint venture which to this date was exactly 14 years ago! This was a true area of a medical breakthrough and look where the glp-1's are now...

What I am saying in my humble opinion, is that she dwarfs Sandra's insight and for that fact MIsslings as well. So at the time she was doing this:

Dr. Kellmeyer served as a Senior Manager of Clinical Development at Amylin Pharmaceuticals. During her time there, she was instrumental in the clinical and regulatory strategies required to bring amylin analogs—such as SYMLIN®—to market for type 1 and type 2 diabetes patients. Her extensive work with the FDA and EMA heavily influenced the current landscape of multi-hormonal metabolic therapies

She would make a great CEO, again, imho, in a new area of breakthrough therapy over multiple CNS indications. Take a look at all the SEC filings prior to Missling being dismissed. They are all signed by MIssling and jointly by Missling and Sandra for the quarterlies. I do believe there is a power struggle of some sort going on. Hope I am wrong. Anavex needs new leadership and Terrie, even in an interim role, is a great start.

Grasping at straws.

No one can honestly say Blarcamesine has promise when the data are corrupt and untrustworthy. The CHMP said it best: There is no evidence of safety or efficacy for any indication.

Hope, fear, and greed make Anavex the dream that never dies and never wakes up.

AVXL down 10 cents while markets are up. What a great company.

Shut it down already.

https://seekingalpha.com/article/4918440-anavex-stock-waiting-validation-blarcamesine-shows-some-promise

Bearing in mind that at some point in in time there will be a hundred promising companies to invest in, I do not see the investment case here. Not even close. I view this as a start from scratch thing with nothing but 100 million bucks and a shell, and with Blacarsime to be a failed attempt which among other adminstrative and clinical screw ups, is very probably ineffective based on Euro or U.S. approval requirements. It was a one product company, like most micro bios, and that product is a failure...thinking it was just the case of inept or deceptive management is engaging in yet another deception, this time a self deception. Like cellcetix or NWBO or the stem cell micro cap companies, or the other micro cap dementia/ alzheimer micro caps, I owned them all basically, lost money, walked away as they were just stringing me along, all of them, and as a new owner was a starry eyed fool. The only thing that saved me was getting extremely lucky -- like a blind squirrel -- knowing when to buy and when to sell AVXL in industrial quantities, and really not even knowing that it was also to be a failure, So even though I was incapable of appreciating the danger like everybody else, I saw the wildly extended charts and held my nose, shut my dream machine off, and dumped it all. Extended charts are the surest way to lose your azz in the stock market, in all sectors. This entire biotech sector in particular, reigns supreme, is a three card monty. Regular people, even regular people who are smart, shojuld avoid it.
Avxl: It is a raffle ticket with very low odds. Nobody should ever feel compelled to buy a raffle tickets; only poor people and hopers buy them; unsuccessful types. Move on. PS: I am expecting this general market, virtually all sectors to go down in the near and intermediate time spans. It is wildly overvalued. Do yourself and your money and loved ones a favor and simply hold your nose and punch up the 10 year chart of the Naz or the S and P. They both look like Avxl during its two fabulous speculative based on nothing runs, the one time from around 3.50 post reverse split to 13, and then several years later, even worse, from 5 bucks to 32 bucks.........those charts are what the major market charts today look like. American investors are gonna take a terrible beating which will have profound effects on their standards of living.

But did they file the proper report to be in compliance with the NASDAQ? Did they address the data issues that were collected inappropriately, the side effects that were questionably reported according to the EMA, and did they address what status our upcoming trials or what the AD fate is with Blarcamesine?

“And given the filings delay, he also left behind a mess and under a dark cloud.“

I can only imagine what a mess he left, though it’s not surprising given his career track record. He is one bad hombre.

It does look somewhat better but I will never believe anything when it comes to this stock until I actually see it I've been around way too long

For years Missling was consistently cagey or evasive about the SAP, endpoints, data, etc. It's good he's gone, and no surprise. And given the filings delay, he also left behind a mess and under a dark cloud.