Anavex Life Sciences Corporation (AVXL)

Ern Heaven is one of about 70 people still taking blarcamesine each and everyday.



Good luck and GOD bless,

I'm trying to wait long enough to see what comes out of this, it will be something to just find out what Dr. Kellmeyer and the other scientific experts within this failing company come up with and then see what happens to Chris Missling's adamant confident stance....it's worth the price for the view. $2.60 or so....ha ha

Steve 😊

It's the right thing to do. As I've said many many times though, I'm holding till they file for bankrupcy or actually become successful. I no longer give a righteous schitt.

If Missling is about to be exposed as a criminal and a fraud, would he be posting on LinkedIn? It seems he values his reputation in this field. He’s a part of our cns story and I believe he wants us to succeed. I pray he hasn’t turned hostile and has taken his humble pie in stride. Let’s get some clarity. Damn it!

They had some help. Maybe an attempted murder suicide. They are in the emergency room.

You follow the Demark system and so far we are down 7. Tomorrow might be a good day for exhaustion. I have stopped looking at my account which is usually a good sign we are near a bottom. Playing more golf and working in the garden. It is beautiful in the mountains of North Carolina. Came within a stroke of shooting my age yesterday with a triple on the last hole. YUK

Thanks Steve, I am not sure if I should feel comforted by that?

That should be suicide since they did it to themselves, right?

BDR10

I read something yesterday somewhere that they have discovered that thousands of deceased persons have been receiving Social Security, various benefits from programs issued by our government!

One female person was reported to be 129 years old...... (holy smokes !)

My wife has to "prove" that she is alive by taking a video of her on my cell phone before Germany will send her the pension that she has; it's a pain to do this each and every year!!!

Hahaha...lol...funny stuff!

Investor:

It certainly does not look great considering that we hit a lower lower low (below the prior lows), but I do see the stock attempting to form some sort of low based on the 5 wave break from around $3.70 which seems to conform to an Elliott wave sequence. The RSI is still hanging in tough by NOT following the price swing low, so that is a positive divergence, clearly (we did NOT break 30).

The last 5 days we have some indication of an effort to turn back up.....but no clear cut "signal".

Waiting for some sort of news might be better...but here's the look....

https://stockcharts.com/sc3/ui/?s=AVXL&id=p0


https://finviz.com/stock?t=AVXL&ty=c&ta=1&p=d

The longer the silence, the more suspicious we all become. Terrie needs to lay the cards on the table. I’m sure they have already spoken to major institutional shareholders. 

The beating for longs never seems to stop with this stock .

No, there is no difference. Short answer:
In corporate governance, “Director” and “Member of the Board of Directors” mean the same thing — a Director is a member of the Board. The terms are interchangeable in U.S. corporate law and banking governance.

🧩 Why the terms sound different but aren’t
Both terms refer to individuals elected to the Board of Directors to oversee the company, set strategy, and exercise fiduciary duties.

A Director is simply an individual who sits on the Board.

A Board Member is the same thing — someone who serves on the Board.

Someone call 911 there’s been a stock homocide!!!

Wow! Did I just read this? In this case, the injection went into one eyeball of a single person with glaucoma. The company did not share any other information about the patient. Over the next six months, scientists will be watching to see how well the technique works, while doctors keep an eye out for any safety issues.

That’s true. But there’s a difference between a Memeber of the BOD and a Director of the company.

Please follow your own advice.
if this dogschitt goes up 10 cents SELL.

Why would they? Houston we have a vacum.and it is not a hoover

Who at the company cares about patients, shareholders or anyone but themselves?

Nothing complex about a shareholder vote for members of the BOD. You either vote yes or no. It's really quite easy.

I think very soon we're going to find out that MISSLING was the lying crook that we all thought he was.... and lately each day we are now producing new 52-week lows.... but there's nothing to worry about because the Dead Guy ERN, and 70 other of his dead Buddies are still taking the drug that no one knows if it even works..

A CEO is usually fired for cause and retained on the board as a compromise to prevent costly legal battles, secure a smooth executive transition, or appease controlling shareholders. Since removing a director often requires a complex shareholder vote, the board may temporarily keep them on board

He needed to get a good wig like Trevor Lawrence.
We do have 5 waves down. That might be a problem.

I think it was a combination of intentionally misleading investors and too many missed haircut appointments.

Read Missling’s employment agreement. Being wrong about thinking small trials would be sufficient to get approval is not grounds for being fired for cause.

Right now the problem is silence. We speculate as to why. Mayo said it was the lawyers. What did Missling do to be fired for cause. Not pay bills? Take kickbacks from Lincoln? Seuxal harassment.? Falsify data? Who knows?
Breaking below 2.50 opens up 2 and below. BTW the whole sector is very weak.

Anavex must have had their anti-aging formulas stolen.... I thought we were the only people with the life-altering anti-aging serum that could be taken by pill form, but apparently someone had to have stolen it and made it in the form of an injection....https://www.yahoo.com/news/science/articles/first-ever-reverse-aging-drug-100002558.html

So where exactly do I now begin this post with all you bio tech experts?
Oh yes how’s about - “SELL” this dog of a stock. That should do it for today’s lesson. I thank you.

Where are we at now in TA terms - a quadrable bottom or are we already at septuple and can expect to be rich the longer we wait?

I think Hosai gave a more interesting thought process, maybe my point needed to be worded better!

It was important to know that the Anavex Scientific Group was looking at the data as it was submitted and that it should stand apart from Missling's habit of keeping everything pertaining to data hidden or worse, etc.

Dr. Kellmeyer, Dr. Sabbagh, Dr. Gabelle, Dr. Liedtke, Dr. Jin, Dr. Ma and all of those other folks in the backroom took part in this failure.

The realistic look is that the CHMP effort was a complete failure and Missling then threw in the towel....

Common Grounds for Firing a CEO "For Cause"While every employment contract defines "cause" differently, these are the most common categories that trigger such a termination:Dishonesty and Fraud: This includes accounting manipulation, falsifying expense reports, misappropriating company funds, or intentionally misleading the board/investors. Breach of Fiduciary Duty: Executives are "fiduciaries," meaning they have a legal obligation to act in the company’s best interest. Acting with a conflict of interest, self-dealing, or unauthorized disclosure of confidential information is a direct violation of this duty.
Serious Misconduct: This encompasses actions that damage the company's reputation or violate core workplace policies, such as sexual harassment, discrimination, or abusive behavior toward employees.
Insubordination: Willful and persistent refusal to follow lawful, board-mandated directives or company policies.
Criminal Activity: Conviction of a felony or other significant criminal acts, especially those related to the workplace or business operations.
Gross Negligence or Incompetence: While simple poor performance (missing a target) is rarely "cause," gross neglect—such as a total failure to enforce safety standards in a high-risk industry—can qualify.Why "Performance" Is Rarely the ReasonIt is a common misconception that poor financial performance is a primary reason for a "for cause" firing.
Research (such as studies by Leadership IQ) shows that CEOs are more often pushed out due to:Mismanagement of Change:
Failing to rally the organization during strategic shifts.Ignoring Stakeholders:
Losing touch with customer needs or alienating key partners.
Denying Reality: Refusing to acknowledge bad news or adapt to market feedback.
Tolerating Low Performers: Losing credibility by failing to hold subordinates accountable.
The Distinction Between CEO and DirectorIt is vital to distinguish between the two roles:The CEO role is an employment position. The board can fire an employee for "cause" based on their contract.
The Director role is a governance position. A director is usually elected by the shareholders, not hired by the board. Therefore, the board cannot unilaterally fire another director. They can only:Request resignation (which the director can refuse).Call a special shareholder meeting to vote on the director's removal (an "ordinary resolution"). Petition a court (in extreme cases of oppression or illegal conduct) to have the director removed.If a CEO is fired as an employee but remains on the board, it is usually because the board lacks a specific "automatic resignation" clause in the CEO's contract and is wary of the costs and publicity of a formal shareholder removal vote.
Disclaimer: I am an AI, not an attorney. Corporate governance and employment law are highly jurisdiction-specific (e.g., laws in Ontario under the OBCA may differ from those in other provinces or countries). If you are involved in or observing such a situation, please consult with legal counsel specializing in corporate law.

Heading back to a fresh new 52 week low. They should go back to being a printing company.

IMO, Missling did nothing evil. I saw it as he was totally in the belief that he could prove small studies were as effective as large studies. After seeing some results in Australia, (watch George's videos), and seeing the traditional endpoints were not as special as the real-life results, it became a deep dive into data seeking answers. The problem is simply that there wasn't enough data to support the conclusions of the deep dive in the opinions of the old guard. Missling may be right in his final, but until there's enough data to support his conclusions, our money was wasted. Doc kept saying the studies were designed wrong and too small. If I listened completely to Doc, I would have done much better than I did. The old guard won and Missling lost.

Same old same old - if this dogschitt goes up 10 cents SELL.

Thank you - this has been my biggest laugh of the week.
Imagine if you will, a CEO of a bank stock just going to a mic and announcing, “there is definitely money in our vault.”
Now, perhaps, everyone can laugh. That’s a keeper!!
Disclaimer: this is not to say that anything is known of behind the scenes right now, only that the above mentioned strategy has “Not even close” written all over it. Eye roll. Good Lord - 

"That is basically my thinking and the fact that the Interim CEO, Terrie Kellmeyer, has not come out with a concrete statement about what has been reported as legitimate scientific data,"

I don't get this idea SAB...it would be quite strange for the CEO to out of nowhere say "all our data is legitimate data" I imagine the sp would probably fall at her bringing up such a thing.
Obv if some legitimate source had challenged their data as being "real" then this would make sense to come out with such a statement. As things stand the only source if the CHMP saying methodological issues etc, however CHMP also said this about the MABS in their full EMA reports.

As I’ve said, I think the lawyers are now in control and have told management to keep silent. I’d be shocked if this isn’t tied up in a legal battle that will go on for a while. No way Missling is going to go quietly.

Would be interesting to see the results of a properly designed and powered P3 trial that includes the ABCLEAR 2/3 subgroups in the SAP.

When might that happen...?

That is basically my thinking and the fact that the Interim CEO, Terrie Kellmeyer, has not come out with a concrete statement about what has been reported as legitimate scientific data, is worrisome.....at this point, an encouraging statement from her would be welcomed!

You hit on the most sensitive and scary thing....did Missling keep this information hidden from Dr. Jin, Dr. Sabbath, and Dr. Gabelle when he knew the data was bad.

Surely, by now, they know exactly what was possibly misinformation! No "good news" ?????

☹️

The problem is we don’t actually know whether the data can be trusted. Missling routinely moved goal posts, changed end points and cherry picked data. He fooled a lot of retail investors whose hopes, fears and greed drove investment decisions that cost a lot of them a lot of money. (By the way, the reviewers in Europe weren’t fooled by the data.) That is why a properly designed and sized phase 3 trial was and is needed. Only then can we be sure of the results. Whether or not you like it, that is what needs to happen.

Yah! It must have been BP that got Missling fired for cause.

Should a safe drug proven with over 9 years of drug trial results with no deaths be approved? I believe it should be immediatly approved. Imo

Col24a1 has also appeared in two AD astrocyte papers:

2022 paper - COL24A1 appeared among the genes distinguishing Alzheimer's-associated astrocytes from normal astrocytes.
https://www.cell.com/neuron/fulltext/S0896-6273(22)00244-6 (figure 4d).

2024 paper - COL24A1 was part of a relatively select astrocyte population involved in helping maintain and remodel the brain's local tissue environment as Alzheimer's disease progresses.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11614739/

Interesting in the context of the stronger brain-preservation signal seen in COL24A1 WT patients in ABCLEAR 2/3, as these studies repeatedly place COL24A1 in brain cells involved in responding to neurodegenerative stress.
Col24a1wt patients had 48.5% less whole brain deterioration than placebo (p=0.0003) whereas for ITT was 37.6% less whole brain deterioration (p=0.0019).

Big Pharma interference.Should be investigated Imo

Yep. The complete silence tells you all you need to know. Maybe we'll never hear from the company again.

The company is trash.  It’s over or it will need to start from scratch.  SAVA 

Can you imagine, this guy might operate a road vehicle.

This pre-print was from a few days ago, it looked at post mortem human brains parkinsons and non-parkinsons. One of the peripheral findings was that astrocytes in parkinsons brains showed significantly higher COL24A1 expression than control astrocytes. COL24A1 was significant enough to be highlighted on the astrocyte volcano plot in figure 3b.
Astrocytes are the brain's support and maintenance cells. They help maintain synapses, regulate the environment around neurons, respond to injury, and play an important role in preserving healthy brain tissue.
https://www.medrxiv.org/content/10.64898/2026.06.04.26354575v1.full.pdf

So, glad you do agree with what I posted.

So, glad you do agree with what I posted.