DarthYoda
1日前
Could be boom time soon. Check this stuff out...The guy nominated to be the new head of the FDA is Dr. Marty Makary. The news has kinda painted him as anti-cannabis so far. However...he has also publicly acknowledged the therapeutic properties of cannabis. So...for starters here is a quote I found from him in a book review on Amazon...
"The CBD Skincare Solution: The Power of Cannabidiol for Healthy Skin":
"An eye-opening book about how the anti-inflammatory effects of CBD can play an important role in skin health and in improving lives."Marty Makary, MD, John Hopkins physician and New York Times bestselling author of The Price We Pay
https://www.amazon.com/CBD-Skincare-Solution-Cannabidiol-Healthy/dp/0738764884
Next, check this out..."How will Trump Nominations Impact the Dietary Supplement Industry?":
"Industry thought leaders discussed the prospect of Robert F. Kennedy, Jr. at the helm of HHS and Dr. Marty Makary in charge of FDA."
January 6, 2025
“FDA promised that they’re going to answer our citizen petition by July … if you have people in charge who are thinking about a much more holistic approach, they’re much more likely to balance the pharmaceutical industry’s interest and the supplement industry’s interest in a way that we think the law was intended,” Mister said. “The previous administration sat on the CBD issue for over 5 years, and didn’t do anything except conclude that they can’t regulate it,” concurred Israelsen.
https://www.nutraceuticalsworld.com/exclusives/how-will-trump-nominations-impact-the-dietary-supplement-industry/
Here is the petition...
"CRN Petitions FDA to Change Course on ‘Drug Preclusion’":
May 10, 2023
CRN asked for clearer and more consistent application of the statute which prohibits ingredients from dietary supplements due to past drug research.
https://www.nutraceuticalsworld.com/breaking-news/crn-requests-fda-to-change-course-on-drug-preclusion/
https://www.crnusa.org/sites/default/files/pdfs/comments-pdfs/CRN-CitizenPetition-FDA-DrugPreclusion050923.pdf
Going forward, the hearing to confirm Dr. Makary as head of the FDA is Thursday March 6 at 10:00am:
Hearings to examine the nomination of Martin Makary, of Virginia, to be Commissioner of Food and Drugs, Department of Health and Human Services. Thursday, Mar 06, 2025 10:00 AM
https://www.senate.gov/committees/hearings_meetings.htm
DarthYoda
1週前
Lots of different stuff below...
"DeFloria Receives Investigational New Drug Application Clearance from FDA for Phase 2 Clinical Trial of AJA001, an Oral Cannabinoid Drug Being Developed for the Treatment of Autism Spectrum Disorder (ASD)":
Feb 24, 2025
https://www.prnewswire.com/news-releases/defloria-receives-investigational-new-drug-application-clearance-from-fda-for-phase-2-clinical-trial-of-aja001-an-oral-cannabinoid-drug-being-developed-for-the-treatment-of-autism-spectrum-disorder-asd-302382573.html
"With RFK Jr. in charge, supplement makers see chance to cash in":
2/21/2025
Last fall, before being named the senior U.S. health official, Robert F. Kennedy Jr. said the Trump administration would liberate Americans from the FDA's "aggressive suppression" of vitamins, dietary supplements, and other substances — ending the federal agency's "war on public health," as he put it.
With Kennedy now in the driver's seat, the industry will likely expect more: It aims to make bolder health claims for its products and even get the government, private insurers, and flexible spending accounts to pay for supplements, essentially putting them on an equal footing with FDA-approved pharmaceuticals.
On Feb. 13, the day Kennedy was sworn in as secretary of Health and Human Services, President Donald Trump issued a "Make America Healthy Again" agenda targeting alleged corruption in health regulatory agencies and instructing them to "ensure the availability of expanded treatment options and the flexibility for health insurance coverage to provide benefits that support beneficial lifestyle changes and disease prevention."
Kennedy has said exercise, dietary supplements, and nutrition, rather than pharmaceutical products, are key to good health. Supplement makers want consumers to be able to use programs like health savings accounts, Medicare, and even benefits from the Supplemental Nutrition Assistance Program, or SNAP, to pay for such items as vitamins, fish oil, protein powders, and probiotics.
The Alliance for Natural Health hopes that in lieu of strict FDA standards, Kennedy will enable companies to make expanded marketing claims based on evidence from non-FDA sources, Verkerk said, such as the National Institutes of Health's nutritional information site, which describes the pros and cons of different supplements.
https://www.msn.com/en-us/health/other/with-rfk-jr-in-charge-supplement-makers-see-chance-to-cash-in/ar-AA1zvjw7
"Possibilities of energy utilization of CBD extraction by-product":
17 February, 2023
During the last decade, the global pharmaceutical industry was primarily focused on cannabinoid extraction (mostly cannabidiol – CBD) from dry hemp (Cannabis sativa L.) biomass. Depending on the extraction method used, the first raw cannabinoid extract amounts to an average of under 10 % of total biomass. The remaining share of 90 % is waste. The aim of this research was to determine the usability of industrial hemp waste after the ultrasound extraction in ethanol for energy production via direct combustion and pyrolysis. The biomass of industrial hemp, variety Fortuna, was used in the research. Analyses were carried out by using standard methods for determining the content of proximate and ultimate analyses, Ash content was found to be 15,40 %, coke content was 22,12 %, fixed carbon was 8,12 %, whereas volatile substances were found to be 68,81 %. The obtained HHV was 16,60 MJ kg-1, while LHV was 15,35 MJ kg-1. After the pyrolysis process, the share of produced biochar (50.45 %) and bio-oil (13.70 %) was determined. The composition of biochar was analyzed using the standard methods – moisture content of 2.71 %, ash 29.22 %, and coke 37.06 %. The obtained results confirmed the potential of CBD extraction by-products in terms of high energy value and environmentally friendly raw materials for energy production. It has proven to be an attractive source of energy that has the potential to partially replace raw materials of fossil origin in energy production.
https://www.croris.hr/crosbi/publikacija/prilog-skup/830682
"Understanding Voluntary Carbon Markets and Hemp’s Potential for Change":
December 16, 2024
How It Works
1.Credits Are Generated: Projects like reforestation, renewable energy development, and sustainable regenerative farming techniques create carbon credits by eliminating or avoiding emissions.
2.Credits Are Verified: To ensure the project’s credibility, verification bodies confirm that the claimed reductions are real, measurable, and longterm.
3.Credits Are Traded: Buyers, typically companies looking to offset their emissions, purchase the credits, supporting the funding of these projects.
Challenges in the Current System
1.Complex Verification: Proving the effectiveness of carbon-reduction projects often requires sophisticated monitoring systems, making entry daunting for smaller participants.
2.High Costs: Smaller players, including smallholder farmers or grassroots projects, struggle with the financial burden involved in generating and navigating carbon credits.
3.Transparency Issues: Some markets lack clarity on where funds go and how environmental benefits are quantified, raising concerns about accountability.
Why Hemp? Why Now?
Hemp has long been praised for its environmental benefits, but its potential as a powerful carbon-sequestration crop is only beginning to be realized. Unlike many other crops, industrial hemp not only removes CO2 but also regenerates the soil, making it an ideal candidate for nature-based carbon credits.
Hemp’s Unique Advantages
1.Rapid Growth: Industrial hemp is one of the fastest-growing plants, capable of absorbing significant quantities of CO2 during its short growth cycle.
2.Versatile Applications: Beyond its environmental benefits, hemp can be used to produce textiles, construction materials, biochar, and more, creating additional economic opportunities.
3.Sustainability: Unlike some carbon-offset solutions, hemp farming leaves the land enriched, making it a regenerative approach to climate action.
https://hempcarbonstandard.org/understanding-voluntary-carbon-markets-and-hemps-potential-for-change/
DarthYoda
2週前
"Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice":
18 February 2025
Abstract
Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD promotes muscle injury recovery in athletes, but whether and how CBD improves endurance performance remains unclear. Here we investigated the effects of CBD treatment on exercise performance in mice and assessed whether this effect involves the gut microbiome. CBD administration significantly increased treadmill running performance in mice, accompanied by an increase in oxidative myofiber composition. CBD also increased mitochondrial biogenesis and the expression of associated genes such as PGC-1a, phosphorylated CREB and AMPK in muscle tissue. Interestingly, CBD altered the composition of the gut microbiome, and antibiotic treatment reduced the muscle endurance-enhancing effects of CBD and mitochondrial biogenesis. We isolated Bifidobacterium animalis, a microbe increased by CBD administration, and named it KBP-1. Treatment with B. animalis KBP-1 in mice resulted in improved running performance. Whole-genome analysis revealed that B. animalis KBP-1 presented high expression of genes involved in branched-chain amino acid biosynthesis, expression of branched-chain amino acid release pumps and metabolism of lactic acid. In summary, our study identified CBD and B. animalis KBP-1 as potential endurance exercise-promoting agents.
https://www.nature.com/articles/s12276-025-01404-5
DarthYoda
1月前
I vaguely remember posting about heavy metals, hemp, batteries, CBD, etc a long time ago, but there does now seem to be even more connections worth investigating. What condition does RFK say some vaccines can cause? Autism. What does RFK say one of the biggest problems are with vaccines? Heavy metals. What does RFK suggest people with Autism try? Chelation to remove heavy metals...
http://www.autismpolicyblog.com/2024/10/rfk-jr-and-chelation.html?m=1
What protects against heavy metals toxicity? CBD. What can improve life and symptoms for people with Autism? CBD. There seem to be profound connections between CBD, heavy metals, and Autism. Thankfully, these connections are being investigated. Hopefully, this research can lead to Ajna001 being fast tracked by FDA for Autism treatment.
"Exposure to heavy metals may increase risk of autism":
https://www.medicalnewstoday.com/articles/317754
"Association of autism with toxic metals: A systematic review of case-control studies":
2022 Jan
The findings from this review demonstrate that high levels of toxic metals are associated with ASD, therefore, critical care is necessary to reduce body burden of these metals in children with ASD as a major therapeutic strategy.
https://pubmed.ncbi.nlm.nih.gov/34896416/
DarthYoda
1月前
I know my metals talk has nothing to do with the company's current business plan, but it does look like I was onto something...Because of the battery and electric vehicle boom Nickel is actually the metal for which phytomining is being researched the most...The new research below is exactly what should be done with hemp. It may turn out to be the best candidate for the job...
"US scientists engineer plant to harvest precious minerals, improve soil, create biofuel":
1/28/2025
“Our idea” Dhankher said as per the UMass Amherst release, “is to determine which genes and proteins are responsible for Alyssum’s nickel hyperaccumulation, then re-engineer Camelina so that it, too, can hyperaccumulate nickel. We also want to determine which soil amendments will optimize the engineered Camelina’s ability to pull even more nickel from the soil.”
https://www.msn.com/en-us/science/environmental-science/us-scientists-engineer-plant-to-harvest-precious-minerals-improve-soil-create-biofuel/ar-AA1y081c
"The Feds Are Trying to Get Plants to Mine Metal Through Their Roots":
Mar 21, 2024
Some species can absorb extreme amounts of nickel from soils. Such “phytomining” could help provide batteries essential for the renewable revolution.
Of the 350,000 known plant species, just 750 are “hyperaccumulators” that readily absorb sky-high amounts of metals and incorporate them into their tissues.
https://www.wired.com/story/the-feds-are-trying-to-get-plants-to-mine-metal-through-their-roots/
With that all being said, if hemp is now also being looked at to pull PFAS(forever chemicals) out of the ground, you gotta wonder if CBD can protect against the effects of PFAS, similarly to how it can protect from heavy metals toxicity...
"Viability of Hemp as a PFAS Remediation Tool Moves Forward, as Contamination Spreads":
January 23, 2025
“Starting in 2025, the Mi’kmaq Nation, [Upland Grassroots], [University of Virginia], the Connecticut Agricultural Experiment Station and Central Aroostook Soil and Water Conservation District will use a four-year, $1.6 million EPA grant to continue hemp planting at [the former] Loring [Air Force Base] and testing potential ways to extract PFAS [per- and polyfluoroalkyl substances] from harvested hemp.”
https://beyondpesticides.org/dailynewsblog/2025/01/viability-of-hemp-as-a-pfas-remediation-tool-moves-forward-as-contamination-spreads/
"Minnesota Just Became the First State to Target Plastic Chemicals in Food":
January 22, 2025
On January 16, Gustafson introduced bill SF 188, which aims to pressure food manufacturers to reduce their use and levels of phthalate chemicals — plasticizers used to make plastics more flexible and durable — in their products.
https://www.foodandwine.com/minnesota-bill-sf188-phthalate-testing-packaged-foods-8777895
DarthYoda
1月前
Hey good to see you Fangster. I agree about the food. There are a lot of issues in this sector. All are government dependent unfortunately. There is no free market. There is no sense in how they approach food, drugs, dietary supplements, even without cannabis. So much needs to be fixed. However, next week on Feb 5th there will be a banking hearing so maybe that is a start...
https://www.marijuanamoment.net/marijuana-businesses-tell-gop-senate-committee-about-struggles-accessing-financial-services-ahead-of-debanking-hearing/
Oh, and FWIW, hemp plants CAN pull soluble precious metals like Gold and Palladium out of the ground. It's called phytomining, but there hasn't been much effort to research it thoroughly to see how well it could work after things like selective breeding for enhanced metals absorption...
"Phytoextraction of palladium and gold from Broken Hill gossan" :
2015
A second trial used Cannabis sativa (Hemp) due to recorded metal tolerance of this species. Pots were re-seeded with C. sativa. Hemp germinated and grew well relative to B. juncea. Potassium cyanide solution (50 mL of 8 g L-1) was applied to each pot at the point of maximum biomass to induce the solubility of precious metals and therefore to induce hyperaccumulation. Significant metal concentration values after KCN treatment were as follows: Copper (6,726 µg g-1) > nickel (184 µg g-1) > palladium (62 µg g-1) > gold (9 µg g-1). Following established criteria values, copper, palladium, and gold hyperaccumulation was observed. The mean metal concentrations of copper, nickel, and palladium from Hemp grown in soil B were greater compared to Hemp grown in soil A and control plants (p < 0.05). However, gold concentration between Hemp A and Hemp B was not different significantly (p > 0.05).
https://mro.massey.ac.nz/items/58b8f1c0-2e1b-4180-b374-90125a6b8446
"Phytomining: Can plants really grow gold?":
May 1, 2013
https://www.mgsrefining.com/blog/phytomining-can-plants-really-grow-gold/
"Phytomining of noble metals – A review":
6 August 2021
https://www.sciencedirect.com/science/article/pii/S0045653521022773
DarthYoda
1月前
"100% of Fast Food Samples Tested Positive for Heavy Metals, Lead, and Cadmium":
October 12, 2023
Summary
-100% of the fast food samples tested contained alarming levels of cadmium.The levels of cadmium were between 74%-1158% higher than what the EPA allows in drinking water.
-Cadmium is highly carcinogenic and can cause toxic reactions even at low levels.
-In-and-Out french fries had 1,158% higher levels of cadmium than what the EPA allows in drinking water.
-Jack-in-the-Box french fries had 970% higher levels of cadmium than what the EPA allows in drinking water.
-100% of the 42 fast food samples tested had trace amounts or higher of lead.
-Even low levels of lead in blood have been shown to negatively affect a child’s intelligence, ability to pay attention, and academic achievement.
-A Sonic Drive-in cheeseburger had the highest amount of lead, 912% higher than what the EPA allows in drinking water.
-Arsenic was also detected in 17% of the fast food samples.
-The highest level of arsenic was found in Panda Express’s orange chicken and white rice at 362% higher than EPA levels allowed in drinking water.
Cadmium
The highest level of cadmium was found in fast food french fries. This is presumably because potatoes are grown in the ground and absorb more heavy metals in the growth process. In-and-Out had 1,158% higher levels than what the EPA allows in drinking water, and Jack-in-the-Box had cadmium levels 970% higher than what the EPA allows in drinking water. According to a March 2023 paper by Wang et al. “Cadmium (Cd) is a highly carcinogenic metal, which can cause toxic reactions even at low concentrations. Long-term ingestion of high-dose Cd can cause serious health problems (Ankit et al., 2021).
The paper further explains how cadmium may be polluting food. “Application of sewage sludge, farmyard manure, or some commercial fertilizers may also increase Cd levels in the soil (Bigalke et al., 2017, Kubier et al.,)” The paper also points to reasons “such as dumping of domestic or industrial wastewater (Rao & Kashifuddin, 2016), and misuse of phosphate fertilizer.”
https://www.momsacrossamerica.com/fast_food_heavy_metals
You would think our "food" would at least have to be as clean as our cannabis, but no.
DarthYoda
5月前
"Fourth Circuit Court Rules Hemp-Derived Products Legal Nationwide, Contradicting DEA":
Sep19, 2024
The Fourth Circuit Court of Appeals has ruled that all hemp-derived products, including those created through chemical synthesis, are legal under federal law.
This ruling aligns with a 2022 decision from the Ninth Circuit but goes against more recent guidance from the DEA. In a letter from February 2023, the DEA stated that the 2018 Farm Bill was not intended to legalize synthetic cannabinoids, such as THC-O, even if their THC content is below the legal limit.
Despite acknowledging the disagreement, the Fourth Circuit sided with the Ninth Circuit’s interpretation, which held that the Farm Bill’s definition of hemp includes all cannabis plant derivatives as long as they contain less than 0.3 percent delta-9 THC. The court stated that this interpretation is clear and that they did not need to defer to the DEA’s position.
“The Ninth Circuit held that it didn’t need to consider the DEA’s position on synthetically derived substances because the definition of ‘hemp’ under the 2018 Farm Act was unambiguous in its application to all products derived from the cannabis plant, ‘so long as they do not cross the 0.3 percent delta-9 THC threshold,’” states the court. “Between the DEA’s February 2023 letter and [the Ninth Circuit decision], we think the Ninth Circuit’s interpretation of the 2018 Farm Act is the better of the two. And we’re free to make that determination ourselves, despite a contrary interpretation from the DEA, because we agree with the Ninth Circuit that § 1639o is unambiguous.”
The case arose from a dispute over whether an employer could fire an employee for using hemp products. The court ultimately upheld the firing because the employee failed to prove the products used were compliant with the THC limits outlined in the 2018 Farm Bill.
https://themarijuanaherald.com/2024/09/fourth-circuit-court-rules-hemp-derived-products-legal-nationwide-contradicting-dea/
"New Study Reveals CBD’s Surprising Ability To Combat Deadly Mosquitoes":
September 20, 2024
CBD results in 100% mortality of pesticide-resistant mosquito larvae.
New research in the effort to address global insecticide resistance has found that CBD, commonly used to manage various health conditions, is also highly effective in eliminating mosquito larvae.
The study, published in the journal Insects, found that hemp leaf extract – which contains the active ingredient cannabidiol, or CBD – kills mosquito larvae from two different strains of the yellow fever mosquito within 48 hours, one that was resistant to typical insecticides and another that was not.
“Mosquitoes are one of the deadliest animals in the world, mainly because as adults they serve as vectors of disease,” said Erick Martinez Rodriguez, lead author of the study and a graduate student in entomology at The Ohio State University. “It’s very important to be able to control these pests at an early stage, when they are at the most vulnerable.”
Unlike adult mosquitoes that can fly across great distances and transmit disease by biting, mosquito larvae are aquatic organisms often found in standing water. Conventional synthetic insecticides are critical chemical tools for killing mosquito larvae populations, but their rampant overuse has led to both insecticide resistance and other detrimental effects on the environment.
Challenges of Conventional Insecticides
Inspired by previous Ohio State research that discovered that the bark properties of a plant native to Madagascar worked as a natural mosquito insecticide and repellent, Martinez Rodriguez sought to determine if hemp could act as a viable and safe alternative to current biopesticides.
The hemp plant is related to marijuana, but does not contain its levels of the ingredient that makes people feel “high.” CBD from hemp is used in a variety of products from gummies and oils to treat anxiety, pain, insomnia, and other conditions.
To test hemp’s toxic effects against mosquito larvae, the team took air-dried hemp leaves, pulverized them into a fine powder, and soaked the material in methanol for a few weeks to reach the desired CBD concentrations.
The methanol was later removed from the solution to make it easier to chemically analyze, resulting in an extract that was eventually given to the larvae with their food.
Depending on the concentration of hemp extract used, the team discovered that the hemp leaf was potent enough to be equally toxic to both strains of mosquito larvae. What was surprising, though, said Martinez Rodriguez, was the small amount needed to be so deadly.
“If you compare the amount of hemp extract needed to kill 50% of the population to other synthetic conventional insecticides, it is on the high side, but when you compare it side-by-side to other natural extracts we have tested in our lab, only a relatively low amount is required to produce high mortality values in larvae,” said Martinez Rodriguez. While CBD eventually led to 100% mortality for the larvae, different concentrations of the hemp extract caused different mortality rates in the hours leading up to that time.
Hemp’s Advantages and Future Research Directions
The mosquito larvae were considered dead if no movement was recorded after scientists gently touched their abdomen with a needle or pipette tip. Although it’s still unclear how the extract affects them biologically, the team’s findings showed that CBD was the primary active ingredient in the extract and that it can successfully bypass the larvae’s metabolic resistance to other insecticides, which aligns with past work that found CBD has notable growth-inhibiting properties against other insects.
Since hemp is also a more sustainable crop than many other plant alternatives, insecticide products that use it could potentially be produced relatively cheaply, said Martinez Rodriguez.
While this discovery bodes well for developing future natural-based mosquito control products, said Peter Piermarini, co-author of the study and a professor of entomology at Ohio State, further research would have to be done to investigate how safe hemp and CBD would be for non-target organisms, like honey bees or other pollinating insects that scientists don’t want to kill or disrupt by introducing potentially harmful additives to the environment.
“CBD is a compound that appears to be safe for people and our companion animals to ingest,” said Piermarini. “It’ll be interesting to learn more about how CBD interacts with various proteins in mammals and insects to understand why it’s safe for people but not insects.”
Reference: “Larvicidal Activity of Hemp Extracts and Cannabidiol against the Yellow Fever Mosquito Aedes aegypti” by Erick J. Martínez Rodríguez, P. Larry Phelan, Luis Canas, Nuris Acosta, Harinantenaina L. Rakotondraibe and Peter M. Piermarini, 9 July 2024, Insects.
DOI: 10.3390/insects15070517
This work was supported by the Infectious Diseases Institute and the College of Food, Agricultural, and Environmental Sciences at Ohio State. Other Ohio State co-authors include Larry Phelan, Luis Canas, Nuris Acosta and Harinantenaina L. Rakotondraibe.
https://scitechdaily.com/new-study-reveals-cbds-surprising-ability-to-combat-deadly-mosquitoes/
Wolf-man jack
7月前
“ Charlotte's Web Holdings, Inc. (TSE:CWEB) just released its latest quarterly report and things are not looking great. It definitely looks like a negative result overall with revenues falling 14% short of analyst estimates at US$12m. Statutory losses were US$0.07 per share, 40% bigger than what the analysts expected. Following the result, the analysts have updated their earnings model, and it would be good to know whether they think there's been a strong change in the company's prospects, or if it's business as usual. Readers will be glad to know we've aggregated the latest statutory forecasts to see whether the analysts have changed their mind on Charlotte's Web Holdings after the latest results.
Following the recent earnings report, the consensus from three analysts covering Charlotte's Web Holdings is for revenues of US$50.8m in 2024. This implies a measurable 6.9% decline in revenue compared to the last 12 months. The loss per share is expected to greatly reduce in the near future, narrowing 33% to US$0.19. Before this earnings announcement, the analysts had been modelling revenues of US$57.5m and losses of US$0.22 per share in 2024. We can see there's definitely been a change in sentiment in this update, with the analysts administering a meaningful downgrade to next year's revenue estimates, while at the same time reducing their loss estimates.
The consensus price target fell 14% to CA$0.65, with the dip in revenue estimates clearly souring sentiment, despite the forecast reduction in losses.”
https://finance.yahoo.com/news/earnings-release-heres-why-analysts-122818344.html
DarthYoda
7月前
"Citing failures to protect public health, lawmaker looks to remove FDA's food authority":
August 2nd 2024
Rep. Rosa DeLauro (D-CT), who's been in Congress for more than three decades, has had enough.
She's introduced legislation to remove the FDA's food authority and start fresh with a new agency: The Federal Food Administration.
https://wjla.com/resources/pdf/1425c052-a30c-4578-90ea-6744f83ac635-TAM24855.pdf
The agency sent us the below statement:
"As you may be aware, in May the FDA reached a significant milestone with approval of its reorganization involving the creation of a unified Human Foods Program (HFP), adoption of a new model for its field operations and other significant modernization efforts. The reorganization implementation is currently targeted for Oct. 1, 2024, notably enhancing the agency’s ability to oversee and protect the human food supply and other products the FDA regulates. The reorganization will enable the FDA to be more efficient, nimble and prepared for the ever-changing and complex industries we regulate, new food and medical product technologies, as well as the impacts of globalization, climate change and other factors that require the agency to quickly adapt.
Additional information can be found here:
https://www.fda.gov/about-fda/fda-organization/fda-modernization-efforts-establishing-unified-human-foods-program-new-model-field-operations-and
https://wjla.com/news/spotlight-on-america/toxic-baby-food-fda-citing-failures-protect-public-health-formula-bacteria-heavy-metals-tainted-applesauce-rosa-delauro-connecticut-test-contaminants-safe-products
DarthYoda
7月前
I found a recently published research paper that was funded by Charlotte's Web, and I threw in a couple more papers below it as well. The one funded by Charlotte's Web is focused on a new cannabinoid called Cannabielsoin or CBE, (there is S-CBE and R-CBE, this paper focused on S-CBE), which is an oxidation product of CBD. You guys know I love seeing stuff like this...Enjoy!
"Cannabielsoin (CBE), a CBD Oxidation Product, Is a Biased CB1 Agonist":
Published: 12 July 2024
Funding
Funding for this study was provided by Charlotte’s Web.
https://www.mdpi.com/2227-9059/12/7/1551
"Cannabidiol ameliorates lipopolysaccharide-induced cardiovascular toxicity by its antioxidant and anti-inflammatory activity via regulating IL-6, Hif1a, STAT3, eNOS pathway":
18 July 2024
Results
Histopathological analysis of the LPS group showed moderate hyperemia, hemorrhages, edema, inflammation, and myocardial cell damage. There was a slight to moderate increase in Cox-1, G-CSF, and IL-3 immunoexpressions, along with enhanced expressions of IL-6, Hif1a, and STAT3 genes, and decreased expressions of eNOS genes. Additionally, there were increased levels of TOS and decreased TAS levels observed biochemically. CBD treatment effectively reversed and improved all of these observed changes.
Conclusions
CBD protects the heart and aorta against systemic inflammation through its antioxidant and anti-inflammatory activity via regulating IL-6, Hif1a, STAT3, and eNOS intracellular pathways.
https://link.springer.com/article/10.1007/s11033-024-09772-3
"Cannabinoid Content and Label Accuracy of Various Hemp-Derived Haircare, Cosmetic, and Edible Products Available at Retail Stores and Online in the United States":
19 July 2024
Results: Ninety-seven products were purchased (35 in-store, 62 online). Of the 71 products with a specific total CBD amount on the label, 35 (49%) were underlabeled (>10% more CBD than advertised), 27 (38%) were overlabeled (>10% less CBD than advertised), and 9 (12.7%) were accurately labeled (within ±10% of labeled CBD). The median (range) percentage deviations were -53% (-100%–76%) for haircare products, +18% (-100%-1076%) for cosmetics, and -1% (-100%-4468%) for food/drinks. CBD label accuracy did not differ significantly between products with external testing claims versus those without (t40 = 0.23, p = 0.82). Overall, 24% of the 97 (total) products made a cosmetic or beauty claim (e.g., “skin looks more youthful”), 40% made a therapeutic claim (e.g., “pain relief”), and 86% made a health halo effect claim (e.g., “paraben-free,” “dye-free,” etc.). Most products (63%) did not include a disclaimer that claims had not been evaluated by the FDA.
Conclusions: Most of the products included in this sample were inaccurately labeled for CBD content, including those claiming to have been tested by third party laboratories. A notable finding was that 10 products did not contain any CBD. Many products made therapeutic claims or used marketing tactics to seemingly convey they were safe/healthy, but only about one-third included disclaimers that these statements had not been evaluated by the FDA. These findings highlight the need for proper regulatory oversight of cannabinoid-containing products to ensure quality assurance and deter misleading or unfounded health claims in product marketing.
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0039
DarthYoda
8月前
"Case Report: Cannabis Oil Treats Common Skin Disease in Dog":
JUL 11, 2024
Veterinary students and scientists in Brazil used cannabis oil to successfully treat a dog with a common skin disease that did not respond to previous treatment. The corresponding study was published in Frontiers in Veterinary Science.
Discoid lupus erythematosus (DLE) is a common autoimmune disease that typically affects the skin on the nose and ears of dogs. It is characterized by inflammation, loss of hair pigment, and redness, which can lead to crusting and ulceration. The condition's underlying cause remains unknown; however, it is thought to arise from a mix of genetics, infections, hormones, and sun exposure. Current treatments include corticosteroids to reduce inflammation; however, these carry a risk of unwanted side effects.
Previous research suggests that cannabinoids cannabidiol (CBD) and tetrahydrocnnabidiol (THC) reduce inflammation in both dogs and humans without any detrimental side effects.
In the current case report, a two-year-old female mixed-breed dog with DLE was not responding to corticosteroids and other medications. The researchers thus decided to treat the dog with cannabis oil.
After some experimentation, they found that cannabis oil containing CBD and THC on a ratio of 3:1 worked best. To begin, the dog was given a single drop orally once daily for three days to test for negative reactions. The treatment continued after no negative reactions were reported, and the dosage was slowly adjusted until the minimum effective dose was found. After several weeks, some signs of DLE started to disappear, and after a year, all symptoms were relieved.
"After 1year, the dog remains clinically stable on a low dose of full-spectrum CBD-rich oil. No evidence of DLE recurrence was observed," wrote the researchers in their paper.
“This case suggests that cannabinoid therapy (CT) may be a viable alternative or complementary therapy for DLE in dogs, particularly for those experiencing adverse effects from conventional treatments. Further research is warranted to confirm the efficacy and safety of CT for DLE management in dogs,” continued the researchers.
https://www.labroots.com/trending/cannabis-sciences/27420/report-cannabis-oil-treats-common-skin-disease-dog-2
Here is the actual paper...
"Case report: Cannabinoid therapy for discoid lupus erythematosus in a dog":
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1309167/full
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