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Moderna Inc (MRNA)
Moderna Inc (MRNA) オプション

Moderna Inc (MRNA)

35.61

1.31

(3.82%)

終値： 3月8日 6:00AM

36.1497

0.5397

( 1.52% )

取引時間後: 8:39AM

MRNA ライブオプションフロー

オプションコール

行使価格	買値	売値	前回の価格	中間価格	前日比	前日比 %	出来高	建玉	最終取引
31.00	4.55	6.25	4.90	5.40	1.56	46.71 %	215	846	05:27:37
31.50	2.85	6.00	4.45	4.425	1.20	36.92 %	8	509	04:27:46
32.00	2.81	3.75	3.85	3.28	1.50	63.83 %	645	1,545	05:30:54
32.50	2.99	3.30	3.10	3.145	1.04	50.49 %	268	25,411	05:47:04
33.00	1.95	2.78	2.80	2.365	1.10	64.71 %	256	1,118	05:49:54
33.50	1.76	2.18	2.10	1.97	0.92	77.97 %	215	907	05:39:32
34.00	1.27	1.71	1.59	1.49	0.74	87.06 %	485	1,408	05:54:11
34.50	1.00	1.41	0.42	1.205	-0.19	-31.15 %	502	925	05:49:12
35.00	0.51	0.70	0.59	0.605	0.18	43.90 %	3,612	2,291	05:56:44
35.50	0.08	0.19	0.17	0.135	-0.13	-43.33 %	778	910	05:58:57
36.00	0.01	0.01	0.01	0.01	-0.18	-94.74 %	3,835	26,190	05:54:53
36.50	0.01	0.01	0.01	0.01	-0.13	-92.86 %	2,387	1,512	05:37:34
37.00	0.01	0.01	0.01	0.01	-0.09	-90.00 %	3,209	950	05:35:10
37.50	0.01	0.01	0.01	0.01	-0.08	-88.89 %	4,032	500	05:37:25
38.00	0.01	0.01	0.01	0.01	-0.05	-83.33 %	3,971	1,802	05:34:29
38.50	0.01	0.06	0.02	0.035	-0.04	-66.67 %	1,701	122	03:37:53
39.00	0.01	0.01	0.01	0.01	-0.06	-85.71 %	1,404	879	05:15:50
39.50	0.01	0.01	0.01	0.01	-0.03	-75.00 %	214	189	05:30:33
40.00	0.01	0.01	0.01	0.01	-0.02	-66.67 %	2,837	1,332	05:21:15
40.50	0.01	0.19	0.03	0.10	-0.05	-62.50 %	16	14	01:11:28

ポートフォリオを強化: リアルタイムのディスカッションと実用的な取引アイデア。

プレミアム

オプションプット

行使価格	買値	売値	前回の価格	中間価格	前日比	前日比 %	出来高	建玉	最終取引
31.00	0.01	0.01	0.01	0.01	-0.04	-80.00 %	20	1,603	05:54:11
31.50	0.01	0.01	0.01	0.01	-0.04	-80.00 %	234	1,294	02:11:07
32.00	0.01	0.01	0.03	0.01	-0.07	-70.00 %	91	1,180	01:48:28
32.50	0.01	0.01	0.01	0.01	-0.15	-93.75 %	22	607	01:42:21
33.00	0.01	0.01	0.01	0.01	-0.23	-95.83 %	297	603	05:17:16
33.50	0.01	0.01	0.01	0.01	-0.40	-97.56 %	601	646	03:19:24
34.00	0.01	0.01	0.02	0.01	-0.57	-96.61 %	353	1,277	04:06:28
34.50	0.01	0.05	0.11	0.03	-0.66	-85.71 %	146	359	01:15:31
35.00	0.01	0.01	0.01	0.01	-1.14	-99.13 %	2,789	932	05:28:01
35.50	0.01	0.02	0.02	0.015	-1.47	-98.66 %	836	36	05:48:34
36.00	0.31	0.48	0.43	0.395	-1.33	-75.57 %	5,531	81	05:59:57
36.50	0.58	1.10	0.84	0.84	-5.30	-86.32 %	5,109	32	05:58:25
37.00	1.11	1.49	1.24	1.30	-3.28	-72.57 %	2,123	47	05:50:38
37.50	1.56	2.05	2.06	1.805	-3.79	-64.79 %	287	392	05:57:59
38.00	2.26	4.15	2.18	3.205	-0.87	-28.52 %	1,059	38	05:17:16
38.50	0.57	4.95	1.27	2.76	-4.70	-78.73 %	11	3	01:10:04
39.00	1.33	5.15	3.21	3.24	-2.19	-40.56 %	23	20	05:52:50
39.50	1.58	5.95	1.85	3.765	-3.75	-66.96 %	2	2	01:59:09
40.00	2.25	6.25	4.10	4.25	-1.42	-25.72 %	12	52	05:27:00
40.50	3.05	7.95	6.50	5.50	0.00	0.00 %	0	2	-

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axelvento

axelvento 20時間前

Moderna at TD Cowen Conference: Strategic Diversification Focus $$$$$$$$$$

On Wednesday, 05 March 2025, Moderna Inc. (NASDAQ: MRNA) participated in the TD Cowen 45th Annual Healthcare Conference. The discussion, led by Tyler Van Buren from TD Cowen and Steven Hoege, President of Moderna, highlighted the company’s strategic initiatives, including product diversification and cost reduction. While Moderna remains committed to its ambitious growth plans, it also acknowledged potential challenges, such as lower COVID vaccination rates and market uncertainties.

Key Takeaways
Moderna aims for 2025 vaccine sales between $1.5 billion and $2.5 billion.
The company targets cash breakeven by 2028 through diversification and cost management.
Moderna’s product pipeline includes vaccines for RSV, flu COVID combo, norovirus, and CMV.
The individualized neoantigen therapy (INT) program is a key focus in oncology.
Moderna is prepared to advance its bird flu vaccine program as needed.
Financial Results
Moderna reiterated its 2025 sales guidance of $1.5 billion to $2.5 billion, acknowledging potential headwinds.
The company aims to achieve cash breakeven by 2028 through product launches and cost reductions.
Cash investment is projected to decrease from $6.4 billion in 2024 to $5 billion in 2026.
Operational Updates
RSV Vaccine: Contracting discussions are ongoing, with label expansion under review for high-risk 18-59 year olds.
Flu COVID Combo Vaccine: No revenue expected in 2025, with a 2026 opportunity pending efficacy data.
Norovirus Vaccine: Data expected in 2026, with trials paused due to a Guillain Barre syndrome case.
INT Program: Phase 3 melanoma trial fully enrolled, with potential approval in 2027.
Bird Flu Vaccine: Phase 3 study in the U.S. under agreement, with a proactive approach to pandemic preparedness.

Future Outlook
Product Launches: Aiming to launch 10 products in three years, with three files under FDA review.
Cost Discipline: Continued cost reductions to balance investment and revenue by 2028.
Q&A Highlights
RSV Competition: Moderna aims to offer the broadest label and strong efficacy for its RSV vaccine.
Flu Season: Challenges include declining vaccine coverage and evolving influenza viruses.
Flu COVID Combo vs. Monotherapy: Two-thirds of the population prefer the combination vaccine, though monovalent products will remain significant.

Full transcript - TD Cowen 45th Annual Healthcare Conference:

https://www.investing.com/news/transcripts/moderna-at-td-cowen-conference-strategic-diversification-focus-93CH-3913103

👆️ 1 👍️ 1 😀 2

axelvento

axelvento 2日前

Moderna anticipates 2027 release for cancer vaccine in collaboration with Merck

https://www.investing.com/news/stock-market-news/moderna-anticipates-2027-release-for-cancer-vaccine-in-collaboration-with-merck-93CH-3909817

👆️ 1 💪 1

axelvento

axelvento 2日前

BioNTech and Pfizer must pay damages to Moderna for the use of one of its patents in Germany. This was the ruling handed down today by Düsseldorf Regional Court in the dispute over mRNA vaccines. It is the second win for Moderna after a favourable ruling in London last year.

https://www.juve-patent.com/cases/moderna-and-freshfields-triumph-in-dusseldorf-against-biontech-and-pfizer/

Vexari

Before the measles vaccine

We had the Brady Bunch

Telling it like it is

Natural immunity from measles is lifelong

While vaccines push endless boosters

Trust your immune system

Not the pharma-driven panic

~ Dr Sherri Tenpenny ~

Fear mongering = vaccine push

Must keep those dollars rolling

From the uneducated

Must feel good

About that

👎️ 1 💊 1 🗑️ 1 🤪 1

tw0122

MRNA $32s bottom feeder $$$$

axelvento

axelvento 3日前

insider buy$ https://www.secform4.com/filings/1682852/0001127602-25-007904.htm

👌 1 👍️ 1 💯 1

axelvento

axelvento 3日前

Moderna CEO Stephane Bancel purchases $5 million in company stock

Bancel acquired a total of 160,314 shares of Moderna’s common stock, with purchase prices ranging from $31.04 to $31.53 per share.

https://www.investing.com/news/insider-trading-news/moderna-ceo-stephane-bancel-purchases-5-million-in-company-stock-93CH-3907204

👆️ 1 👌 1 👍️ 1

axelvento

axelvento 4日前

-clown- RFK Jr urges Americans to get vaccinated amid measles outbreak: ‘A call to action’

https://www.hindustantimes.com/world-news/us-news/rfk-jr-urges-americans-to-get-vaccinated-amid-measles-outbreak-a-call-to-action-101740995866989.html

👍️ 1 💯 1 😀 1

axelvento

axelvento 6日前

Recent advances and perspectives on the development of circular RNA cancer vaccines

https://www.nature.com/articles/s41541-025-01097-x

👆️ 1 👍️ 1 😀 1

axelvento

axelvento 7日前

Moderna Receives Medicines and Healthcare Products Regulatory Agency Marketing Authorization in the UK for RSV Vaccine

https://investors.modernatx.com/news/news-details/2025/Moderna-Receives-Medicines-and-Healthcare-Products-Regulatory-Agency-Marketing-Authorization-in-the-UK-for-RSV-Vaccine/default.aspx

👍️ 1 💯 1 🔝 1

axelvento

axelvento 1週前

Killer T cells could hold key to future 'bird flu' vaccines, study suggests

https://medicalxpress.com/news/2025-02-killer-cells-key-future-bird.html

axelvento

axelvento 1週前

Moderna to Present at Upcoming Conferences in March 2025

https://investors.modernatx.com/news/news-details/2025/Moderna-to-Present-at-Upcoming-Conferences-in-March-2025/default.aspx

👆️ 1 👍️ 1 💯 1

axelvento

axelvento 2週前

From Tumor Biology to Breakthrough Therapies: The Rise of Personalized Cancer Vaccines

Notably, in the KEYNOTE-942 trial (NCT03897881) led by Jeffrey S Weber, investigators observed improved relapse-free survival (RFS) with a combination of neoantigen vaccines and pembrolizumab (Keytruda; Merck & Co), marking a significant step forward in clinical translation.1,2 This phase 2b study evaluated the efficacy and safety of mRNA-4157 (V940; Moderna and Merck), an mRNA-based individualized neoantigen therapy, combined with pembrolizumab vs pembrolizumab monotherapy in patients with resected high-risk melanoma (stage IIIB-IV). The trial enrolled 157 patients across the US and Australia, randomized 2:1 to receive either the combination therapy or monotherapy.2

At a median follow-up of 24 months, the combination therapy improved RFS (HR 0.561, P=0.053), with 18-month RFS rates of 79% vs 62% in the monotherapy group. The combination therapy was associated with more grade 3 or higher treatment-related adverse events (AEs, 25% vs 18%), though no grade 4 to 5 events were attributed to mRNA-4157. Immune-mediated AE rates were similar between groups.2

Overall, the findings suggest that mRNA-4157 plus pembrolizumab enhances RFS with a manageable safety profile, supporting the potential role of mRNA-based neoantigen therapy in the adjuvant treatment of high-risk melanoma.2

With promising results such as those observed in the KEYNOTE-942 trial, Wu explained that pharmaceutical industry has begun to provide funding for larger studies investigating neoantigen vaccines in the adjuvant and neoadjuvant settings. For example, one study (NCT05933577) investigating melanoma (nearly finished) received funding from Merck and Moderna and enrolled 1089 patients. Another study (NCT06295809) investigating cutaneous squamous cell carcinoma in the adjuvant and neoadjuvant setting (will be commencing soon) also received funding from industry and has enrolled 1000 patients. Other studies include investigations into renal cell carcinoma (RCC, NCT06307431), bladder (NCT06305767), non-small cell lung cancer (NCT06077760), and resected pancreatic ductal adenocarcinoma (NCT05968326), all in the adjuvant setting with between 200 and approximately 900 patients enrolled.1

“Now we're getting—with support from industry—not 10 or 15 patient studies, but rather on the order of 200 and even more than 1000 patients,” Wu said. “I think in the time to come, we'll be able to really, truly look at the clinical impact of such vaccines.”

https://www.pharmacytimes.com/view/from-tumor-biology-to-breakthrough-therapies-the-rise-of-personalized-cancer-vaccines

👍️ 1 🔝 1 😀 1

Vexari

What if cancer

Is a parasite

👎️ 1 🕳️ 1 🗑️ 1 🚽 1 🤪 1

axelvento

axelvento 2週前

Yale doctor's use of ‘cancer vaccine' makes waves after early trials show promising results

The patients remained cancer-free for nearly three years, up until the study ended, Braun said. “We’re able to generate a long-lasting, anti-cancer immune response with the vaccine,” he said.

The next stage is a larger trial, in partnership with pharmaceutical companies Merck and Moderna, that will test the vaccine in combination with other treatments in 270 patients around the world. The first patient who enrolled in the new trial is being treated at Yale Cancer Center, Braun said.

https://www.nature.com/articles/s41586-024-08507-5

https://www.ctinsider.com/business/article/yale-cancer-vaccine-kidney-tumor-dna-research-20173018.php

👍️ 1 💯 1 🔝 1

axelvento

axelvento 2週前

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

https://www.nature.com/articles/s41586-024-08508-4

axelvento

axelvento 2週前

-history repeats itself - New coronavirus with potential to cause pandemic discovered in China

The new virus is even closer related to MERS, a deadlier type of coronavirus that kills up to a third of people it infects.

HKU5-CoV-2 is strikingly similar to the pandemic virus, sparking fears that history could repeat itself just two years after the worst was declared over.

https://www.dailymail.co.uk/health/article-14421599/coronavirus-potential-cause-pandemic-discovered-china.html

👆️ 1 🤑 2

Vexari

Reading between the lines

Now up for reassessment

🕳️ 1 🗑️ 1 🚽 1 🤪 1 🫵 1

axelvento

axelvento 2週前

$BNTX Experimental vaccine for common cancer shows potential in clinical trial
Some pancreatic cancer patients showed immune response to mRNA vaccine

Vinod Balachandran, MD, principal investigator of the trial and senior study author at MSK, stated his optimism about the efficacy of this treatment.

"We find that with RNA vaccine technology, we can teach the immune system to recognize pancreatic cancer, and this immune response could potentially last for many years," he said.

"The ability to trigger a robust, long-lasting immune response is a requisite feature for any cancer vaccine."

https://www.foxnews.com/health/experimental-vaccine-common-cancer-shows-potential-clinical-trial

axelvento

axelvento 3週前

Kennedy has downplayed concerns about his anti-vaccine sentiments, saying in a Senate hearing that “all of my kids are vaccinated, and I believe vaccines have a critical role in healthcare.”

FDA Issues Back-to-Back Vaccine Approvals as RFK Jr. Takes HHS Seat

As they say, history repeats itself
https://www.biospace.com/fda/fda-issues-back-to-back-vaccine-approvals-as-rfk-jr-takes-hhs-seat

👆️ 1 💯 1

axelvento

axelvento 3週前

Cancer Vaccines: https://finance.yahoo.com/news/cancer-vaccines-market-track-major-180000959.html

Leading cancer vaccine companies such as IO Biotech, Merck, Moderna, Candle Therapeutics, ISA Pharmaceuticals, PDS Biotechnology, PDC*line Pharma, LG Chem, AVEO Oncology, Archival Farma, and others are developing novel cancer vaccines that can be available in the cancer vaccines market in the coming years.

Some of the key cancer vaccines in the pipeline include IO102-IO103, mRNA-4157 (V940) + KEYTRUDA, CAN-2409, Nelipepimut-S + Cemiplimab, PDS0101 + Pembrolizumab, PDC*lung01, LB-LR1109, RUTI, and others.

👆️ 1 🔜 1

axelvento

axelvento 3週前

Scientists Crack The Code For Delivering MRNA Medicine To The Brain

https://scienceblog.com/scientists-crack-the-code-for-delivering-mrna-medicine-to-the-brai/

👍️ 1 💯 1 😀 1

Vexari

Unpacking the lies

~~~ That we've been fed ~~~
(3:04)

Get the truth instead

NaturalNews

To learn more, visit: https://discover.brighteon.com/unpacking-the-lies-weve-been-fed

RFK Jr.

🕳️ 1 🗑️ 1 🤥 1 🫵 1

axelvento

axelvento 3週前

Moderna Earnings: Maintaining Our $102 Fair Value Estimate as Long-Term Pipeline and Strategy Intact

https://www.morningstar.com/company-reports/1264965-moderna-earnings-maintaining-our-102-fair-value-estimate-as-long-term-pipeline-and-strategy-intact?listing=0P0001F631

👆️ 1 💪 1

axelvento

axelvento 3週前

Antidepressant, it's no use......it's just harmful...
$MRNA

Vexari

Not much repeat business

In that model

👎️ 1 💊 1 🕳️ 1 🗑️ 1

Vexari

What is an Antidepressant

Why is it called for

Personalities

Can be damaging

To the hive mind

👎️ 1 🕳️ 1 🗑️ 1 🤪 1 0️⃣ 1

Vexari

How is it currently made

Take out all poisons

Starting point

RFK Jr. Outlines His Health Secretary Priorities in Post-Confirmation Interview With Fox News

‘I’m not going to take away anybody’s vaccine’

https://time.com/7222533/rfk-jr-health-human-services-secretary-confirmation-interview-fox-vaccines/

🕳️ 1 🗑️ 1 🙅 1 🚽 1 🤪 1

axelvento

axelvento 3週前

Revenue: $966 million vs. $942.8 million expected

axelvento

axelvento 3週前

RFK Jr. Is Already Taking Aim at Antidepressants

Conspicuously absent was any explicit mention of childhood vaccines, which Kennedy has long railed against as the head of the anti-vaccine advocacy group Children’s Health Defense.

https://www.motherjones.com/politics/2025/02/kennedy-rfk-antidepressants-ssri-school-shootings/

axelvento

axelvento 3週前

RFK Jr. Outlines His Health Secretary Priorities in Post-Confirmation Interview With Fox News

‘I’m not going to take away anybody’s vaccine’

https://time.com/7222533/rfk-jr-health-human-services-secretary-confirmation-interview-fox-vaccines/

axelvento

axelvento 3週前

Recent Progress and Upcoming Late-Stage Pipeline Milestones

The Company remains focused on a prioritized research and development portfolio, delivering up to 10 product approvals through 2027.

Vexari

What does the confirmation of RFK Jr. mean

~~~ For FDA and Big pharma ~~~
(23:50)

Follow the data

This is historic
- RFK Jr. Confirmed as HHS Head: A Pivotal Moment (0:01)

- Censorship and Corruption in Government Agencies (1:34)

- Proposed Reforms and Legal Actions Against the FDA (2:24)

- Impact on the Nutrition Industry and Big Pharma (7:56)

- Concerns About Heavy Metals and GMOs (12:03)

- Calls for Criminal Prosecutions and Systemic Reform (17:16)

For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews

💊 1 🕳️ 1 🗑️ 1 🫵 1

axelvento

axelvento 3週前

Moderna Reports Fourth Quarter and Fiscal Year 2024 Financial Results and Provides Business Updates

Cash Position: Cash, cash equivalents and investments as of December 31, 2024, were $9.5 billion, compared to $9.2 billion as of September 30, 2024. The increase during the quarter was primarily attributable to the timing of accounts receivable collections.

https://investors.modernatx.com/news/news-details/2025/Moderna-Reports-Fourth-Quarter-and-Fiscal-Year-2024-Financial-Results-and-Provides-Business-Updates/default.aspx

👆️ 1 💯 1

axelvento

axelvento 3週前

Senate confirms RFK Jr. as HHS secretary in 52-48 vote

https://www.foxnews.com/politics/senate-confirms-robert-f-kennedy-jr-serve-trumps-health-secretary

dstock07734

dstock07734 4週前

How about you read the paper first before we have a serious discussion?
https://www.iovance.com/uploads/Chesney-JITC-2022-Efficacy-and-safety-of-lifileucel-TIL-cell-therapy-in-pts-w-adv-melanoma-after-pr-2447-publication.pdf

While you read papers on cell therapy, keep one question in your mind: can the treatment trigger massive and sustainable t-cell (CD4 & 8) infiltration into tumor sites after the treatment stops?

BTW, you don't happen to think that Merck would construct vaccine manufacturing facilities based on the following results on mRNA trials, do you?

https://clinicaltrials.gov/study/NCT03313778
https://pubmed.ncbi.nlm.nih.gov/39115419/

https://jitc.bmj.com/content/8/Suppl_3/A477.1
https://clinicaltrials.gov/study/NCT03313778

https://clinicaltrials.gov/study/NCT05933577
https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.TPS9616

https://s29.q4cdn.com/435878511/files/doc_presentations/2024/Jun/03/asco-2024-adjuvant-melanoma.pdf
https://clinicaltrials.gov/study/NCT03897881

https://ascopubs.org/doi/10.1200/JCO.2023.41.17_suppl.LBA9503
https://www.clinicaltrials.gov/study/NCT03897881

https://pubmed.ncbi.nlm.nih.gov/33016924/
https://clinicaltrials.gov/study/NCT03480152

axelvento

axelvento 4週前

Three Years After Experimental Vaccine, These Patients Are Still Cancer-Free

https://gizmodo.com/three-years-after-experimental-vaccine-these-patients-are-still-cancer-free-2000559585

👆️ 1 💪 1

jondoeuk

jondoeuk 4週前

From memory, one of three pivotal trials ongoing. I know they were planing to start a few more PhI/II trials, including one in pancreatic (based on BNTX data*).

* https://www.nature.com/articles/s41586-023-06063-y https://www.globenewswire.com/news-release/2024/04/07/2858841/0/en/Three-year-Phase-1-Follow-Up-Data-for-mRNA-based-Individualized-Immunotherapy-Candidate-Show-Persistence-of-Immune-Response-and-Delayed-Tumor-Recurrence-in-Some-Patients-with-Resec.html

jondoeuk

jondoeuk 4週前

The vaccine targets five antigens VHL, PBRM1, BAP1, KDM5C, PIK3CA.

From the paper: ''All patients generated T?cell immune responses against the PCV antigens, including to RCC driver mutations in VHL, PBRM1, BAP1, KDM5C and PIK3CA.'' https://www.nature.com/articles/s41586-024-08507-5

MRNA's vaccine targets up to 34 patient-specific neoantigens.

DCVax-L in combination with poly-iclc can certainly fix those highly mutated genes.

There is a reason why NWBO has never disclosed or talked about this trial. NWBO's -L isn't a gene therapy either.

Can you imagine the magnitude of efficacy that the latest version of DCVax-L in combination with keytruda can bring after dendritic cells present hundreds of tumor-associated antigens to immune system?

Again, there is a reason why NWBO has never disclosed or talked about this trial. Also, if a mutation is never transcribed, translated and processed, it cannot stimulate an immune response from T-cells. Looking at the data from Dr Rosenberg's group at the US NCI, as well as others, only approximately 1-6% of the mutations are actually transcribed, translated and processed, presented on the surface and can be recognised by the patient's own T-cells using current methods https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30374-3 https://aacrjournals.org/cancerdiscovery/article/9/8/1022/41919/Unique-Neoantigens-Arise-from-Somatic-Mutations-in https://ascopubs.org/doi/10.1200/JCO.21.02170

dstock07734

dstock07734 4週前

The vaccine targets five antigens VHL, PBRM1, BAP1, KDM5C, PIK3CA. It happens that some of those antigens also exist in three types of brain tumors. DCVax-L in combination with poly-iclc can certainly fix those highly mutated genes. Here I am talking about the version of DCVax-L developed fifteen years ago. Can you imagine the magnitude of efficacy that the latest version of DCVax-L in combination with keytruda can bring after dendritic cells present hundreds of tumor-associated antigens to immune system?

https://www.nature.com/articles/s41586-024-08507-5

axelvento

axelvento 4週前

CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial
Chimeric antigen receptor (CAR) macrophages (CAR-Ms) mediate antitumor immunity via phagocytosis, cytokine release, activation of the tumor microenvironment and antigen presentation. We report results from a non-prespecified interim analysis of a first-in-human, phase 1 clinical trial of CT-0508, an anti-human epidermal growth factor receptor 2 (HER2) CAR-M in patients with advanced HER2-overexpressing tumors. Fourteen patients were treated across two different regimens. Patients with breast cancer and gastroesophageal cancer were primarily enrolled and had to have demonstrated overexpression of HER2 according to the American Society of Clinical Oncology/College of American Pathologists guidelines (HER2 immunohistochemistry 3+ or immunohistochemistry 2+/in situ hybridization-amplified). No lymphodepletion chemotherapy was used before infusion. The primary endpoints were safety and CAR-M manufacturability. Secondary endpoints included cellular kinetics and efficacy using objective response rate, overall survival, progression-free survival and duration of response. No dose-limiting toxicities, severe cytokine release syndrome (≥grade 3) or immune effector cell-associated neurotoxicity syndrome were observed; 44% (n?=?4 of 9, 95% confidence interval?=?14–79%) of HER2 3+ tumors achieved stable disease as best overall response 8 weeks after treatment. No meaningful activity was observed in the HER2 2+ population (n?=?5). Correlative analyses of serial biopsies confirmed that CT-0508 traffics to and remodels the tumor microenvironment, resulting in expansion of CD8+ T cells. These findings demonstrate the preliminary safety, tolerability and manufacturing feasibility of CT-0508 for HER2+ tumors. ClinicalTrials.gov registration: NCT04660929.

https://www.nature.com/articles/s41591-025-03495-z

Carisma and Moderna Expand Collaboration to Develop Two In Vivo CAR-M Therapies for Autoimmune Diseases

https://ir.carismatx.com/news-releases/news-release-details/carisma-and-moderna-expand-collaboration-develop-two-vivo-car-m

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axelvento

axelvento 4週前

data before the market opens on Friday, February 14th. Analysts expect Moderna to post earnings of ($2.86) per share and revenue of $951.09 million for the quarter

axelvento

axelvento 4週前

"there's more" A Phase 3 Non-small Cell Lung Cancer

https://www.merck.com/news/merck-and-moderna-initiate-phase-3-trial-evaluating-adjuvant-v940-mrna-4157-in-combination-with-keytruda-pembrolizumab-after-neoadjuvant-keytruda-and-chemotherapy-in-patients-with-certain-ty/

https://clinicaltrials.gov/study/NCT06077760?term=mRNA-4157&rank=5

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jondoeuk

jondoeuk 4週前

A randomised and double-blind PhII is ongoing https://clinicaltrials.gov/study/NCT06307431

axelvento

axelvento 4週前

https://x.com/moderna_tx/status/1887234640806658174

$MRNA

axelvento

axelvento 4週前

Nine patients with advanced kidney cancer who received an experimental vaccine tailored to their tumors’ specific mutations mounted an immune response to their disease and remained cancer-free for three years, an early-phase clinical trial has shown.

https://gizmodo.com/three-years-after-experimental-vaccine-these-patients-are-still-cancer-free-2000559585

https://www.nature.com/articles/s41586-024-08507-5

Vexari

Understanding what cancer is

Will lead to its prevention

Breaking the matrix

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MetaMonster

MetaMonster 1月前

Moderna needs to buyout RNAZ cure to cancer vaccine and burn the dirty rat shorts that suppressed the only hope for terminally ill cancer patients

tmonkey

tmonkey 1月前

kennedy getting approved will put this dn even more---sure paid off for that bozo to pull out of the race and kiss the donalds arrrrrrrrrrrrrs

axelvento

axelvento 1月前

Work finishes on Moderna Innovation and Technology Centre in Oxfordshire

Construction is now complete on the Moderna Innovation and Technology Centre (MITC), the pharma firm’s new research, development and manufacturing facility at Harwell Campus in Oxfordshire.

Subject to licensure, the first product manufactured at scale at the centre is expected to be a Covid-19 vaccine to support the NHS vaccination programme.

In the event of a pandemic, the site will have the capacity to produce a minimum of 250 million vaccine doses per year.

The MITC also features labs and office spaces to support high-priority pre-clinical and clinical-stage assays.

Its biomarker, bioanalytical, and molecular assay laboratories will process samples from Moderna’s clinical trials to assess the safety and effectiveness of potential therapeutics and vaccines.

Stephen Hoge, MD president of Moderna, said: “We’re immensely proud of our new manufacturing facility and clinical laboratories in Oxfordshire and the significant and ongoing investment into R&D across the UK.

“By investing heavily across clinical trials and research, we aim to drive breakthroughs that could improve patient outcomes, support the UK healthcare ecosystem and ultimately shape the future of medicine.”

Moderna has launched 23 clinical trials in the UK across 110 sites since 2021, involving more than 12,700 people.

It has an ongoing 10-year strategic partnership with the UK government, managed by the UK Health Security Agency (UKHSA).

Prof Dame Jenny Harries, chief executive of the UKHSA, added: “The Covid-19 pandemic demonstrated how government can and must work closely with industry to respond to emerging health threats.

“Our partnership with Moderna exemplifies these opportunities and will support the UK’s ambitions towards the 100 Days Mission, help put the UK at the forefront of new technologies and drive economic growth.

"The completion of construction of this impressive facility marks a real milestone and doing so in less than two years is a remarkable achievement.

“Once regulated, it will help ensure the NHS has rapid access to mRNA vaccines if needed in a future pandemic, as well as open doors to new vaccine products.”

The event at Harwell coincided with the first meeting of the new government’s joint oversight committee, co-chaired by Georgia Gould MP, parliamentary secretary at the cabinet office, and Moderna President, Stephen Hoge.

The committee discussed the progress of their partnership and toured the facility, which is expected to be fully operational later this year.

https://thebusinessmagazine.co.uk/technology-innovation/work-finishes-on-moderna-innovation-and-technology-centre-in-oxfordshire/

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