PennyStockTrader2
2月前
Absolutely fantastic, timingwise my buyback was excellent, pricewise it was ok, bought back more than I had started with which I definitely hadnt planned for at the time, now have sold some in the pre-market, lets see where this goes, it could completely or partially retreat, trust me on that, hence why you must, I repeat must take some profits, how much profits and at what price is very very difficult to determine, but I use percentage move, 52 week hi/low, news or anticipation of future news, how much cash I need for other purchases etc. I try very hard not to use by lifetime average (profit or loss), its hard not to consider it, but I really try to distance myself from that - the market doesnt care what I paid for any shares and neither should I but still its hard. Look at price and where yu think price is going based on factors mentioned, etc. Where would I be out of the stock completely, possibly in the 9s somewhere, I would have to see how it moves, volume, etc. But let me say this for the Nth time - these biotech stocks retreat and usually there is no more news coming for months to support the price. If you can trade them at the lower end of their price history with any kind of success, you can effectively lower your average to the point that all the shares you have are free or very very cheap.
tw0122
2月前
Not bad up 50% now.. We are encouraged that this patient has been treated continuously into the 6th 28-day dosing cycle with no toxicities or AEs observed. While still early in clinical development, we believe PAS-004 is showing early signs of differentiation, indicating PAS-004 has the potential to outperform current MEK inhibitors in terms of safety, reduced administration frequency, and potentially efficacy. Our goal is to provide a once-daily or less frequent dosing treatment with broader application, not only for NF1 but also for other indications.”
Interim Phase 1 Results
Interim Phase 1 Results
Pharmacokinetics (PK)
Plasma exposure increased with an increase in dose and linear PK is observed
Long half-life of approximately 70 hours will allow for once daily dosing or longer intervals
Prolonged systemic exposure with minimal fluctuation in PAS-004 plasma concentration at steady state (Cmax/Cmin ratio of 1.2) indicates a potential to achieve constant target inhibition
PK plasma curve
At steady-state, drug levels peaked at about 5 hours with a geometric mean maximum concentration (Cmax) of 16.2 and 61.3 ng/mL for the 2 mg and 4 mg dose groups, respectively. The mean elimination half-life was 67.9 hours supporting once-daily or less frequent oral dosing.
“PAS-004 has demonstrated distinct properties that we believe are significant advantages for an oral MEK inhibitor. PAS-004 has a significantly longer half-life compared to early-generation MEK inhibitors, particularly those used for the treatment of NF1, which have half-lives of less than 8 hours. The ability to achieve prolonged plasma exposures, as reflected in stable plasma concentrations at steady state, may potentially allow PAS-004 to achieve efficacious doses with a favorable safety profile,” stated Dr. Tiago Reis Marques, Chief Executive Officer of Pasithea.
Safety & Tolerability
No treatment-related adverse events (TRAEs) or dose limiting toxicities (DLTs) observed to date
In the first 2 dosing cohorts (n=6), PAS-004 was shown to be well-tolerated with a favorable safety profile with no drug-related dose interruptions, reductions or discontinuations. There were no drug-related serious AEs (SAE) in any dose arm and no protocol-defined stopping criteria were met. Importantly, at the 2 and 4 mg dose levels no rash or skin toxicity, gastro-intestinal (GI) toxicity, or ocular toxicity have been observed to date.
The study independent Safety Review Committee has completed its safety review of data from the second dose cohort of 4 mg and the Company has initiated cohort 3 dosing at an increased dose of 8 mg in capsules and has filed a protocol amendment to increase dosing schedule.
PAS-004 Demonstrates a Differentiated MEK Inhibitor Profile
Unlike first-generation MEK inhibitors for the treatment of NF1 that require twice-daily dosing (BID) and exhibit short half-lives (
boywonder1
3月前
Dena Greeves, I was never any SPZI. What a liar. Also, I do not know Andrew. Now, go pound the table somewhere else you egoistical moron! I despise your rhetoric as your deception is known in the OTC. The Truth, as no one listens to Dina,anymore. Get your facts straight, and your your hate speech. Dena would be a wonderful drag name, just saying! 98% of OTC markets are scams but there are players like you! STFU, and get on your knees you lippy fool.
dinogreeves
3月前
You want to talk about deception I see? You are seating on another scam, two names on that ticker that didn't settle with me, one name works for toxic funders in lieu of shares, are you also one of them? Are you working with Sterling too, I got your pump scam SPZ*I, what else did I expose idiot. Get your facts straight, you know nothing.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=174812106
subslover
2年前
MIAMI BEACH, Fla., Aug. 18, 2022 (GLOBE NEWSWIRE) -- Pasithea Therapeutics Corp. (Nasdaq: KTTA) (“Pasithea” or the “Company”), a biotechnology company focused on the research and discovery of new and effective treatments for psychiatric and neurological disorders, today announced it will present the preclinical proof of concept study results of its tolerizing vaccine program in multiple sclerosis (“MS”) on August 30th at the international conference “From Laboratory to Clinic: Medicine after COVID” held at Trinity College, Oxford University, United Kingdom.
From Laboratory to Clinic is an annual translational research conference established in 1984 that brings together basic scientists, clinicians, and industry researchers to explore how the latest discoveries in immunology and molecular medicine can be applied to improve clinical medicine. During the Symposium, Pasithea’s Chairman, National Academy of Sciences Professor Lawrence Steinman, will be giving the opening keynote lecture. Other speakers will include Dr. Carola Vinuesa, Professor at the Francis Crick Institute in London; Dr. Gali Alter, Professor of medicine at Harvard Medical School; Dr. Jeffrey Ravetch, Professor and head of the Laboratory of Molecular Genetics and Immunology at the Rockefeller University and Dr. Anne Schaefer, Vice-chair of Neuroscience at the Icahn School of Medicine at Mount Sinai.
“We look forward to presenting our data at this important international conference alongside other world recognized leading authorities in immunology and immunotherapy. The study results support the Company’s commitment to the program and move us further along our path to uncover new and effective treatments for neurological disorders,” said Dr. Tiago Reis Marques, Chief Executive Officer of Pasithea.