By Denise Roland
This article is being republished as part of our daily
reproduction of WSJ.com articles that also appeared in the U.S.
print edition of The Wall Street Journal (February 14, 2019).
The world's largest maker of generic drugs is looking for growth
in an unlikely place: high-price biotech medicines.
Teva Pharmaceutical Industries Ltd., which supplies more than
one in 10 drugs taken in the U.S., has struggled in recent years
with slumping generics prices and heavy debt. Forced to cut
thousands of jobs and shut research facilities, the Israeli company
is now turning to biotech drugs to revive its fortunes.
"We figured out a strategy where we'd continue to be leaders in
generics but really focus our R&D on innovative biologics and
biosimilars," Chief Executive Kåre Schultz said in an interview.
"That's what we're working hard on right now."
Teva's results for 2018 underscore the scale of the challenge he
faces. The company on Wednesday reported a 16% slide in annual
revenue to $18.9 billion, with adjusted earnings per share -- which
strips out one-time items -- falling 27% to $2.92. Teva forecast a
further decline in revenue this year, to between $17 billion and
$17.4 billion.
The outlook and weak sales last year for migraine-prevention
treatment Ajovy, one of Teva's newer drugs, sent the company's
shares down 7.7% on the Tel Aviv Stock Exchange.
Biotech, or biologic, drugs are made using living cells in a
process that resembles brewing. They are much more complex than
pill-form medicines and typically command higher prices because
they target specialty diseases like cancer and rheumatological
conditions.
Teva already sells some biologic drugs, but they make up a small
portion of revenue. Mr. Schultz, who became company CEO just over a
year ago, envisions biologics accounting for about half of Teva's
sales.
Teva doesn't have the financial firepower to buy new drug
prospects and has had to cut its research budget. So Mr. Schultz
has halved the size of the company's research pipeline to focus
purely on biologic drugs. It now has 25 drugs in development,
mostly at an early stage.
The 57-year-old industry veteran zeroed in on biologics after
discovering that Teva already had pockets of expertise in the area
but without focus. "The R&D strategy was really all over the
place," said Mr. Schultz, who joined Teva in 2017 from Denmark's
Lundbeck A/S.
In doing so, he is tapping into a broader trend. Between 2006
and 2016, biologics' share of the pharmaceutical market rose from
16% to 25%, according to IQVIA, a health-care data company.
With its push into biologics, Teva is doubling down on what has
been a lucrative sideline for the company: original, branded drugs.
For years, Teva counted on multiple sclerosis drug Copaxone to
boost profits, but sales are now dropping sharply in the face of
competition from cheaper copies.
That sideline started as a lucky break. In 1987, then-CEO Eli
Hurvitz agreed to help out a friend who was working on a new drug
at Israel's Weizmann Institute by bankrolling the clinical trials
needed to win regulatory approval. In return, Teva got the rights
to sell the drug. According to company lore, Mr. Hurvitz carried
around a piece of paper promising to resign if his risky bet on the
multiple sclerosis drug didn't pan out.
Copaxone was launched 10 years later and has since generated
nearly $50 billion for Teva. At its peak in 2013, it accounted for
a fifth of Teva's sales.
Teva continued to develop innovative drugs, but its efforts
didn't yield enough to replace the revenue lost when cheaper copies
of its blockbuster emerged in late 2017.
Copaxone's decline compounded an already dire situation for
Teva. The company was grappling with heavy debts and a price war in
the U.S. generic-drug market, sparked by consolidation among
pharmacy chains and the influx of new competitors. Mr. Schultz's
predecessor, Erez Vigodman, departed in February 2017, and the
company didn't have a permanent chief executive for nearly nine
months.
Weeks after joining the company, Mr. Schultz launched a
cost-cutting plan that involved eliminating about 14,000 positions,
or a quarter of Teva's staff, and shutting up to 25 of the
company's 80 factories and several research centers.
Mr. Schultz says the turnaround is making progress. Cost cuts
are ahead of schedule, debt has been narrowed and revenue is
expected to start edging up in 2020 as the generics business
resumes growth. Some newer branded drugs, like Ajovy and Austedo
for Huntington's and other movement disorders, could also start to
gain momentum.
Despite his focus on biologics, Mr. Schultz wants Teva to remain
a dominant player in generic drugs. He believes the price decline
that has halved the value of the U.S. generics market over the past
five years is bottoming out.
And the company's R&D push may bring it into familiar
territory: Some of the research projects are for biosimilars,
essentially generics for biologic drugs.
Write to Denise Roland at Denise.Roland@wsj.com
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February 14, 2019 02:47 ET (07:47 GMT)
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