ihubstockmover
3週前
$BCTX " As reported in BriaCell’s recent AACR preclinical poster presentation, Bria-PROS+ demonstrated activation of both adaptive and innate immunity including activation of naïve (resting) T-cells, dendritic cells and natural killer (NK) cells. BriaCell believes these preclinical findings support further clinical evaluation as a potential immunotherapy for prostate cancer. Bria-PROS+ is based on the same Bria-OTS+ platform as Bria-BRES+, BriaCell’s next generation breast cancer immunotherapy candidate, which recently received FDA clearance of its Investigational New Drug (IND) application.
Bria-PROS+ builds on Bria-Cell’s Bria-OTS clinical program in breast cancer, where the first patient dosed experienced the sustained complete resolution of a lung metastasis. This 78-year-old woman with advanced metastatic breast cancer and multiple prior treatment failures achieved complete (100%) resolution of a lung metastasis following four doses of Bria-OTS single agent therapy. The complete response of the lesion, initially observed at 2 months, was subsequently confirmed at 4 months, 6 months, and at 11 months. The patient received 17 cycles of Bria-OTS, completed 12 months of the study, and remains in survival follow-up. "
Frankestin
4週前
My best estimate: approximately 260 enrolled today, reflecting the sharp uptick in site and patient interest since the Nature Medicine feature — now at 70+ active sites.
Of those, approximately 100 are in the TPC arm. With a median OS of approximately 8 months in this heavily pretreated population, exponential decay math puts 85-90 of them already as events. The remaining 54 needed for the 144-event threshold are coming from the experimental arms — roughly 50 patients there have 20+ months of follow-up, well past the 15.6-month Phase 2 median.
Running the numbers across scenarios: if Bria-IMT is performing at Phase 2 levels (median OS approximately 15.6 months), we are at or past 144 events already. If it is outperforming — say median OS 25+ months — we are just below the threshold. Either way, after June every single day without an interim announcement is itself a data point. The longer the silence, the better the drug may be working.
On dilution: four raises since early 2025, the last a 30 million dollar offering in January 2026 at 5.59 per unit. Par for the course in clinical-stage biotech — and with zero debt, a current ratio of 3.42, and a float that remains small, the capital structure is cleaner than the headlines suggest. At approximately 30 million market cap, the market is still pricing this as if the trial doesn’t exist.
Holding. Watching the calendar, not the ticker.
Frankestin
6月前
BriaCell is entering a rare position for a small-cap biotech: a true binary event with substantial upside and meaningful de-risking already in place.
🔹 Why the setup is compelling:
• Exceptional upside potential (uncommon in small-caps)
• Real de-risking driven by multiple predictive biomarkers
• Outstanding safety profile, especially for a cellular immunotherapy
• Early Phase 3 signals already encouraging
BriaCell stands out as the only allogeneic immuno-cellular therapy in breast cancer with:
• Overall Survival (OS) signals in Phase 2
• Initial PFS improvement in Phase 3
• Well-defined predictive biomarkers (NLR, DTH, Th1 signatures)
• Clear clinical benefit in HR+/HER2-low populations
Partnerships or Big Pharma Interest
Big pharma companies do not invest unless there is:
• a validated biomarker,
• a strong safety profile,
• and a credible pathway to approval.
BriaCell now has:
• biomarkers (NLR, DTH, Th1 signatures),
• excellent safety,
• a true Phase 3 program underway.
This is the first time in the company’s history where it can realistically attract major pharmaceutical partners.
• Excellent safety, even in heavily pre-treated patients
surfkast
10月前
BriaCell Therapeutics (NASDAQ: BCTX), a clinical-stage biotechnology company, has announced a 1-for-10 share consolidation to maintain Nasdaq listing compliance. The consolidation is expected to take effect on August 25, 2025, with post-consolidation trading beginning around August 26, 2025, subject to TSX and Nasdaq approval.