Avalo Therapeutics Inc (AVTX)

Avalo Therapeutics shares jump as Guggenheim starts coverage with BuyFebruary 2, 2026 10:36 AM
IH Market News
Shares of Avalo Therapeutics Inc (NASDAQ:AVTX) climbed about 5.8% in premarket trading on Monday after Guggenheim launched coverage on the stock with a Buy recommendation and a $50 price target.Guggenheim analyst Yatin Suneja said he is encouraged by Avalo’s IL-1ß inhibitor, AVTX-009, which is being developed to treat hidradenitis suppurativa (HS), a chronic inflammatory skin disease. He pointed to the therapy’s high-affinity, IL-1ß-specific mechanism as a potential differentiator versus competing treatments, offering greater selectivity and the prospect of less frequent dosing.Avalo is currently running its Phase II LOTUS trial, which includes 250 patients, with topline results expected in the second quarter of 2026. Suneja assigns a 65% chance that the program advances into Phase III development.The analyst also highlighted substantial upside potential, estimating that Avalo’s market value could reach $2 billion to $3 billion in a favorable scenario—equating to roughly a three- to five-fold increase from current levels. Guggenheim projects possible peak global sales of around $2.1 billion for AVTX-009 if it secures regulatory approval.According to the note, Avalo aims to begin a pivotal HS study in 2027, with topline data potentially available by 2029. With the company’s enterprise value currently near $530 million, Suneja believes there is meaningful headroom for further share price appreciation.Avalo Therapeutics stock price

Original: Avalo Therapeutics shares jump as Guggenheim starts coverage with Buy

Should it dip below 10 thinking to re-enter.

Looks like interest is coming back..16.70

?????

$35 next week??

Uh…

AVTX over $20
Next day settlement begins 5/28 per SEC mandate

Crystal ball glowing green

No worry what I'm hearing is more upside coming. AVTX was trading at $1130 last June.

Hearing a lot more coming here. Last June $1130.00 Micro Float.... 700k

#AVTX 🔥 huge move and ready for next week? $avtx

Nope

I took a chance and bought at $20. But missed a 50% profit due to no day trades left. Was hoping it would hold at least $25 for Monday. Oh well. Will be lucky to get out at $15 Monday morning in my opinion.

Same no daytrade stuck at 23

Yes.

Was this CERC?

I'm stuck with this until Monday at 7 am. Out of day trades so hope it holds.

just broke 30..do i hear 35??

AVTX: And ya sold way too EARLY, Dude!!!

AVTX..over 26 mvg again for ph

BCG Wow AVTX What a move!

Another holo? Congrats for the holders here. Will be interesting watching people chase this and lose their a--

As per per, They are getting $115 million upfront payment that will go beyond 2027. And someone mentioned the float is 800k.

Although if you multiply by the peak price at the beginning of winter of about .25 cents... that's like $60.... and .12-.13 where it was mostly at is more like a $30 mark and a break even for many... so... I wouldn't get excited yet

Finally a chance to get out with sizeable returns lol... and hopefully it doesn't tank in the morning and instead runs to 30+ ahaha

Holy smokes! I bought 200 shares of this at 4.91 last Friday and just sold at 22.50 for a sweet 460% profit. That doesn’t happen often. 973$ to 4,500$ in 2 hours.

ELECTION IS COMING

AVTX: So there goes ALL of our trading theories, down the toilet!!! (Now it's grab them any time, & flip them any time!!!)

400 PERCCEEEENT

AVTX: A 6-bagger for sure, even before the looming Open!!!

Wild

https://stockcharts.com/h-sc/ui?s=avtx&p=D&yr=0&mn=6&dy=0&id=p38090673899

https://www.barchart.com/stocks/quotes/avtx/technical-chart?plot=CANDLE&volume=total&data=DO&density=M&pricesOn=1&asPctChange=0&logscale=1&indicators=BBANDS(20,2);SMA(13);PTP(50);ADX(14);SMA(50);SMACD(12,26,9);RSI(14,100);ACCUM;STOSL(14,3)&sym=CNNA&grid=1&height=500&studyheight=100

https://www.barchart.com/stocks/quotes/avtx/opinion

https://finance.yahoo.com/quote/avtx/

Short sell!

NO WAY

LL

Avalo Acquires Anti-IL-1ß mAb and Announces Private Placement Financing of up to $185 Million

$avtx 11.11 NEWS https://ir.avalotx.com/press-releases/detail/183/avalo-acquires-anti-il-1-mab-and-announces-private

https://finviz.com/quote.ashx?t=AVTX&p=d

Cash Position

The company has -2.7 months of cash left based on quarterly cash burn of -$9.3M and estimated current cash of $-8.4M.
https://dilutiontracker.com/app/search/AVTX

AVTX 10Qndueb3/18

AVTX 10Q March 11

AVTX 10Q March 4

RespireRx Pharmaceuticals RSPI $ KRM–II–81 has shown promising results for Epilepsy.
Has fully suppressed the epileptiform activity in the excised brain tissue from a 19-year-old patient with pharmaco-resistant epilepsy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784158/

CERECOR in September 2016 acquired right to Anti Epilepsy Drug LY3130481 from Eli Lilly Cerecor branded drug CERC-611
Cerecor and Aevi Genomic Medicine Merged Feb 2020
Cerecor rebranded into Avalo Therapeutics ticker AVTX
Avalo Therapeutics (formerly Cerecor) is developing AVTX 611 (formerly CERC 611)
November 2022 Avalo Therapeutics enters into an agreement with ES Therapeutics to sell its net economic rights to future payments of previously out-licensed assets including CERC 611
AVTX 611 got rebranded to ES 481 is being developed by ES Therapeutics for the treatment of Epilepsy.
Clinical development is underway in Australia and Canada.
Study Design
Total Participants: 24
Study Start date:
November 21, 2021
Estimated Completion Date:
December 31, 2023

This webpage mentions:
The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81
https://www.sciencedirect.com/science/article/abs/pii/S000689931930410X




The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81
Abstract
The need for improved antiepileptics is clearly mandated despite the existence of multiple existing medicines from different chemical and mechanistic classes. Standard of care agents do not fully control epilepsies and have a variety of side-effect and safety issues. Patients typically take multiple antiepileptic drugs and yet many continue to have seizures. Antiepileptic-unresponsive seizures are life-disrupting and life-threatening. One approach to seizure control is surgical resection of affected brain tissue and associated neural circuits. Although non-human brain studies can provide insight into novel antiepileptic mechanisms, human epileptic brain is the bottom-line biological substrate. Human epileptic brain can provide definitive information on the presence or absence of the putative protein targets of interest in the patient population, the potential changes in these proteins in the epileptic state, and the engagement of novel molecules and their functional impact in target tissue. In this review, we discuss data on two novel potential antiepileptic drugs. CERC-611 (LY3130481) is an AMPA receptor antagonist that selectively blocks AMPA receptors associated with the auxiliary protein TARP ?-8 and is in clinical development. KRM-II-81 is a positive allosteric modulator of GABAA receptors selectively associated with protein subunits a2 and a 3. Preclinical data on these compounds argue that patient-based biological data increase the probability that a newly discovered molecule will translate its antiepileptic potential to patients.

May grab some today. Could be making the turn now

It's possible

Dammmmn down from $1000 in July to $5.... suddenly I have more faith in AMC lol

Hmmmmm!!

www.zacks.com STRONG BUY #1 wowza

45 Million Dollar Milestone payment and over 10 Million in cash no debt This could push cash over 50$ per share waiting for data tiny float now after massive 240 for 1 RS

Back below a dollar in 2024

For shareholders best interest ? tomorrow is the day ! 1 for 240 RS !!! Most wipe out , You make money by trading , they make $$ by RS ....right ?

Dirtbags changed ratio to 240 to 1 and moved the date to the 29th - just doesn't get much more pinkish than this group of clowns.

Ouchhhhheeee 250 to 1 RS tomorrow - the illusion of being a real company continues with a stolen pps increase by theft.