RespireRx Pharmaceuticals Inc (CE) (RSPI) ニュース

Interesting reply in that specifically noted is the seperation of assets/efforts with ResolutionRx and that of RespireRx. Suggestive that there is an overarching plan in place for RespireRx assets not to be intertwined with the OSA program of ResolutionRx. Logical as it fits their commentary in filings and actions or lack of (EM trading status)

The BOD and new VP from a year ago are not listed or updated on website and all platform summaries are from 2022. Needs a significant re-work if Respire is what carries the development efforts forward.

Pharmacol Biochem Behav. 2024 Dec:245:173895.
doi: 10.1016/j.pbb.2024.173895. Epub 2024 Oct 24.
Nonsedating anxiolytics
Rok Cerne 1, Jodi L Smith 2, Aleksandra Chrzanowska 3, Arnold Lippa 4
PMID: 39461622 DOI: 10.1016/j.pbb.2024.173895
Abstract
Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and alprazolam. While the GABAAR PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects including sedation, motor impairment, addictive potential and tolerance development. A substantial effort was thus devoted to the design of GABAAR PAMs as anxiolytics with reduced sedative liabilities. Several non-benzodiazepine (BZD) GABAAPAMs progressed to clinical trials (bretazenil, abecarnil, alpidem, and ocinaplon) with alpidem obtaining regulatory approval as anxiolytic, but later withdrawn from market due to hepatotoxicity. Advances in molecular biology gave birth to a host of subtype selective GABAAR-PAMs which suffered from signs of sedation and motor impairment and only three compounds progressed to proof-of-concept studies (TPA-023, AZD7325 and PF-06372865). TPA-023 was terminated due to toxicity in preclinical species while AZD7325 and PF-06372865 did not achieve efficacy endpoints in patients. We highlight a new compound, KRM-II-81, that is an imidazodiazepine selective for GABAAR containing a2/3 and ß3 proteins. In preclinical studies KRM-II-81 produced anxiolytic-like effects but with minimal sedation, respiratory depression, and abuse liability. Thus, KRM-II-81 is a newly discovered, non- BZD anxiolytic compound, which targets a selective population of GABAAR for improved therapeutic gain and reduced side effects.

Okay, that makes me feel better. That link I found by Googling. I just assumed you could navigate to it through the website, but I tried after reading your post and it doesn't seem as though you can. The URL itself should just be eliminated but at least it's not something you can access from the website.

Thanks for your efforts.

Here is what I just got from the funding investment group handling the sub company . The replie below was to the posting I sent them by All City Baby

Re: LTListener post# 52589

I agree that the current state of the website is quite awful. Not only does it look amateurish, on the company management page it lists Dr. James Manuso as the CEO. He left the company on September 30, 2018.

https://www.respirerx.com/corporate/management.html

https://www.globenewswire.com/news-release/2018/06/19/1526825/0/en/RespireRx-Pharmaceuticals-Inc-Announces-Resignation-of-Dr-James-S-Manuso.html

Happy new year to you too. Thanks for your email.


Maybe check your sources regarding the management page on the company’s website. Link below for your reference.

https://respirerx.com/scientific-team-leaders/

Whilst I appreciate the information you have provided, as previously mentioned I’m assisting with raising capital for ResolutionRX so this is where I’m spending my efforts. If you have queries / concerns, or require information for RespireRX, as you are a shareholder, I kindly suggest you speaking with Jeff Margolis directly

Makes 2 of us . I hold igpk and rdar . My soun absolutely killed it . Looking at U now . Still have rspi for my lottery ! Liking it

Thankyou for taking the entitative with all the e-mails you have sent and being the voice of reason .Not an easy time with the way this company lacks any communication with us shareholders. GLT US ALL this coming year....

It takes more than they currently are at. Only way is a merger at this point would be the quickest , I also wrote Jeff he was on the road and will get back with me , I asked him about letter. I also wrote the investment firm and passed on some of our concerns and pointed out what we all are seeing and feeling and with no info or updates how do they think they will raise funding for RSPI. He was out of office til the 6th so hopefully he will present our concerns to RSPI and ask the same questions we are all concerned about.

https://listingcenter.nasdaq.com/assets/initialguide.pdf

https://www.nasdaq.com/solutions/listings/markets/americas/ways-to-list

Well,

This has been stated in past filings...

"The Company is also engaged in business development efforts (licensing/sub-licensing, joint venture and other commercial structures) with a view to securing strategic partnerships that represent strategic and operational infrastructure additions, as well as cash and in-kind funding opportunities. These efforts have focused on, but have not been limited to, transacting with brand and generic pharmaceutical and biopharmaceutical companies as well as companies with potentially useful contract research, formulation or manufacturing capabilities, significant subject matter expertise and financial resources. No assurance can be given that any transaction will come to fruition and that if it does, that the terms will be favorable to the Company."

Seems like there would be opportunties where some Nasdaq pharma have cash and experience, but maybe less than desired trial results that would be looking for new assets to bring into their world and develop. Could be win-win approach and certainly RSPI lacks significantly in some areas of business development. Could just be reverse merger into Nasdaq shell as well. Seems like this approach would be a better fit for these assets and how they have been non chalant about sticking with the OTC.

Hmmm.... Could Lippa et al. be aiming for listing on the NASDAQ? What would it take to accomplish that?

Meanwhile nasdaq much better than OTC. I'm Here in RSPI as my only OTC value bet. Don't see much value elsewhere.

Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy

Sabhya Rana, Anna F. Fusco, Jeffrey M. Witkin, Daniel P. Radin, Rok Cerne, Arnold Lippa, David D. Fulle
https://doi.org/10.1016/j.pharmthera.2024.108744Get rights and content

Abstract
Ampakines are a class of compounds that are positive allosteric modulators of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and enhance glutamatergic neurotransmission. Glutamatergic synaptic transmission and AMPA receptor activation are fundamentally important to the genesis and propagation of the neural impulses driving breathing, including respiratory motoneuron depolarization. Ampakines therefore have the potential to modulate the neural control of breathing. In this paper, we describe the influence of ampakines on respiratory motor output in health and disease. We dissect the molecular mechanisms underlying ampakine action, delineate the diverse targets of ampakines along the respiratory neuraxis, survey the spectrum of respiratory disorders in which ampakines have been tested, and culminate with an examination of how ampakines modulate respiratory function after spinal cord injury. Collectively, the studies reviewed here indicate that ampakines may be a useful adjunctive strategy to pair with conventional respiratory rehabilitation approaches in conditions with impaired neural activation of the respiratory muscles

LT - I've attended many professional conferences where I usually presented. Deals are not made at the conferences, but at the social gatherings after presentations. I see that Lippa and likely most of RSPI are still and will continue attending these conferences, which of course means RSPI is still open for deal making. In addition, researchers present findings before publication which allows Lippa and Cerne to find new approaches, molecules and preclinical results of RSPI's molecules. I suspect they came by their dronabinol platform through a conference social gathering. Lippa is well regarded in neuropharmacology and also a venture capitalist. He took over Cortex obviously recognizing their platform has huge potential. This is hypothetical, whether or not I am correct we will see hopefully soon.

I bought quiet a few right before they went EM. I'll hold for a buyout which I believe will happen this year .

Thinking about this further...

Someone mentioned these shares as not being marketable, yet implication is still very valuable. That is an ironic status for a company who according to filings have consistently mentioned the OTC as hindering financing activities. So why take it off the market? Why suggest to another poster that only accredited investors can help fund the cash needed for filings and it take months to complete on a not very complex balance sheet/activities? Several comments have suggested the company wanted less interference, noise and keep shares in known/institutional type hands. This makes sense.

Conclusion: They have no concerns about current trading status and/or funding. A "if you build it, they will come" approach... And really if the DOD funded SCI phase 2 gets underway soon, if they land NIH grant funding for KRM-ll-81 in Q1 and if they are connected to the UIC phase 1/2 dronabinol trial sponsored by VA then they are sitting pretty good. Government entities are now likely funding clinicals on all 3 of their platforms in 2025!! Brilliant strategy. It is painful as an investor to see the lack of communication and presentation. Yet that all can be swiftly corrected when they are ready to engage the markets again. Speculation on spinning out assets or moving to another trading exchange is logical and likely on point. I agree with you in that these shares are potentially worth a gold mine if you compare the progress of these assets versus other mid level pharmas well I think this one may rival some of the best storied stocks from the OTC... Definitely excited for the future in the coming months and years to follow the progress. Just don't have the tolerance on a stock forum for getting lambasted for conducting due diligence and investing by some. I appreciate all your DD and the discussions here as it helps build an understanding of what is possible.

Their filings have indicated they consider the OTC to be hindering fund raising. They didn't give much effort to maintain OTC status falling to EM.

Logical to believe another approach is possibly in play. Normal companies supposedly in need of cash would at minimum communicate and present company to prospective investment entities, etc. The lack of suggests they have other plans established and in motion.

Yes.

My next sentence implied that no?

"Maybe they just get funding deal and go straight to Nasdaq?? Have seen mergers before with a company with cash looking for development assets"

"I was suggesting merger with already established Nasdaq company with cash looking for assets".

Is that really what you meant by this?
"Maybe they just get funding deal and go straight to Nasdaq??"

What assets? I wasn't unclear. I said that THE SHARES that you hold essentially are not marketable.

LT - Considering Lippa's history, I don't think a merger is in his nature. Besides, if that were the aim, RSPI would not be in EM. Right? It would be interesting to see who is buying while in EM - could it be RSPI in anticipation of an explosion?

Why aren’t these assets marketable?

Do you think DOD and NIH involvement is a joke?

Sorry if confusing but I was suggesting merger with already established Nasdaq company with cash looking for assets.

I suppose with your level of interest here you would like to see that as well. No?

"Maybe they just get funding deal and go straight to Nasdaq??"
Have you read the NASDAQ listing standards? It wouldn't seem so....RSPI doesn't come close to meeting any of them.
https://listingcenter.nasdaq.com/assets/initialguide.pdf

It says a lot that you actually believe that this board has been read 75,000 times in the last 24 hours. But that's a different issue than the one that was being discussed.....the breakout board IS NOT based on reads. Do I need to explain it again?

Your shit ton of due diligence has resulted in your holding of shares that essentially are not marketable.

I hope that comes true. I have been waiting for almost 5 years now.

It makes you wonder...

Are they serious about drug development and changing people's lives or not?

You just can't do the science part (which I think has positioned their candidates well) and completely ignore the business/stakeholder/communication side of the equation....

This is from last July.

Here’s a repost of my email to Dr Milap Sandhu (msandhu@sralab.org) who will manage CX1739’s clinical trial, funded by the DoD:

Hello Dr Sandhu,

I’m reaching out to you about the recent announcement of a DoD funded study of CX1739. Could you confirm that this is being planned, and if so when will recruitment begin?

I appreciate your time,

Bruno


He promptly replied:

Dear Bruno,

Thank you for reaching out.

Yes, we are planning to initiate a study with CX1739 in individuals with SCI. We are at early stages of this research and it'll take a few months before we begin enrollment.

Are you or someone you know has a spinal cord injury?

Best regards,
Milap

"progress behind the scenes isn't halted"

They just need to get filings done which was supposedly well underway until this "pause" to get off this EM.

But the concern is how many opportunities to attract talent resources, collaborative resources, partnerships, position the company for further fair value investment, build out the shareholder base, position to capitalize on clinical success etc, etc is passing them by??

Nah I don't think so as long as progress behind the scenes isn't halted look at Ltnc spent over a year in EM then suddenly remmerged from 001 to 02 cent run and they got 10x OS than ours

Anyone know anything about the eoy shareholders letter that was promised 

Yep it makes the company look real bad and will also hurt other contracts. Really makes no sense at all. Poor management to say the least. The longer this drags on the harder it will be to get off the expert market.

Curious that the transfer agent has not updated the OS since mid-November. It seems in the past this was a weekly occurrence....

That would be management's choice...

Why on earth they brought this company onto this expert market is beyond me. It really looks silly.

Especially in light of a DOD funded phase 2 on one candidate and working with the NIH on preclinicals and likely phase 1 funding for another candidate as well as significant effort and patent positioning related to their OSA program that the company has chunks of funding lined up at 20 mil valuation, which they stated is low!

Executives and institutional stakeholders have significant funds linked to equity positions. Certainly many see the need for liquidity and capitalizing on their position on 3 different platforms before opportunity to attract resources and investment interest passes them by.

I would hope so...

"I would not be surprised to get an update soon on how the setting up of the trial is unfolding, recruiting of subjects, etc."

They originally stated hoping to initiate trial end of last year. I would think starting fresh in 2025 to get the DOD funds rolling on this phase 2 would be important from many angles.

On top of that I believe according to what I could gleen from NIH websites, that they would hear about grant funding for KRM-ll-81 in the next few months. So a material event related to the gabakine program is likely on the horizon.

And on top of that their OSA program licensor UIC has a VA sponsored dronabinol phase 1/2 projected to start Q1. I would like to know how this program fits within the overall plans/FDA guidance of their OSA program.

I would love that but doubtful. My fear is that we stay on the expert market. Been doing the OTCs a long time and so many end up being pieces of crap. Meanwhile we just hold our shares.

More press mentions RespireRx Pharmaceuticals, in particular the relevance to spinal cord neuroplasticity, which is, by the way the reason why Dr. Dariusz Nasiek joined the board of director, and provided 100000$ in cash, which he arranged to be backed by 33 million shares of RSPI as a disincentive to further dilution.

And in addition, we should bear in mind that the DoD clinical trial funding is specifically about using the new ampakine CX1739 to support therapeutic hypoxia for recovery of spinal cord damage.

So the pieces of the puzzle are coming together. I would not be surprised to get an update soon on how the setting up of the trial is unfolding, recruiting of subjects, etc.

I posted here earlier this year the name of the Dr who will run the trial, and where. I also confirmed with him that this was indeed underway. Let me try to get in touch with him again.

https://www.einnews.com/pr_news/773474888/spinal-cord-injury-therapeutics-market-projected-to-witness-substantial-growth-2024-2031-abbvie-inc-pfizer-inc

https://southeast.newschannelnebraska.com/story/52104007/spinal-cord-injury-therapeutics-market-projected-to-witness-substantial-growth-2024-2031-abbvie-inc-pfizer-inc

Maybe they just get funding deal and go straight to Nasdaq?? Have seen mergers before with a company with cash looking for development assets. Could this be the reason for the non chalant approach the past 6 months??

I mean they think the OSA program is worth 20-40 million. The phase 2 candidate is worth a chunk certainly and KRM-ll-81 with a robust set of successful preclinicals might be more valuable than all the rest combined…

Many think this is worth a nickel or two now in anticipation of multiple clinical trials forthcoming..

So when it shows 75000 reads in a day that is coming from 3 of us permabulls who do a shit ton of due diligence and expecting company executives to meet their fiduciary duties?

And this is similar daily for months on end…. Uh huh.

I agree and they need to get this resolved asap!

Position on the BOB is based on "the change in posting activity in the past 24 hours vs. the average from the prior 7 days", not the number of board reads.
On a board like this just a few posters can have a big influence on a BOB position. For example you and 2 other posters account for more than half of the most recent poster activity, making up the majority of what you refer to as "so much interest in this EM stock".

I think it is board reads…

But why so much interest in this EM stock?

Continually..

Tell him all of it. The Break out board measures posting activity and has zero to do with the Company's operations.

Sadly the more time that goes by they will never get currant. Still makes no sense they didn't file.

Break out board

Bob? What's that? 

Imagine what it will be like if they ever go current again?

Then through in an FDA Approval and or institutional partnerships we could all be celebrating here.

Look at that, RSPI in back on the BoB, not bad for a ticker in the EM!

Some people like the paint color green, some like the paint color red.

I doubt there is any or will be any effort to revive older ampakine compounds. They have already focused soley on the low impact ampakines and have this phase 2 for SCI funded and supposedly I think a presentation a few years back suggested they needed just funding to get CX-1739 or CX717 in ADHD phase 2 clinicals. I am guessing there is way too much risk and stigma with the old high impact compounds. Plus they have an enormously promising gabakine and an OSA program with patent position that both are and can be extremely valuable. Focus and updates need to be centered around these compounds heading into clinicals.

Now maybe in the future they can afford to explore the past with newer technology, but given the current lack of everything seems far fetched to even place into ones imagination...