Innovation Pharmaceuticals Inc (EM) (IPIX)

When do we hear news (good or bad)?

I very seldom, and not at all for years now, checked Pacer for this case: Case 1:24-cr-00243-KMW

I'd like to know how that case was resolved.

Cowtown, you were all jacked about getting oral from Humanagen on June 2. Please keep the shareholders updated, how’d that work out for you? All you ever got from Lying Leo was the Shaft or do you believe otherwise?

As usual, 180 degrees ass-backward. Czech yer maff. One dog year is often stated to be equivalent to 7 to 9 human years. Nott the other way as your calculation indicates.

And however many years, your pennystock investment advice has also been 180 degrees wronGGG. 100 percent LOSS in SPNGQ, 100 percent LOSS in HGENQ, and now a 100 percent LOSS in IPIX.

Hear back from STEVE MNUNCHIN yett? Your iHub posts are ridiculous.

It's a long game, puppy. I've been playing it for over 140 of your years currently.

Humanigen's management sending a signal ahead of oral

Slow pitch.

That did not last too long.....back down to .0003

I've never had the luxury, as you have, to really "go big" on equities. And the shorting experience I have had was mainly related to trading S&P futures. So seeing a penny yield a value of $3,755 for my IPIX shares was a nice experience.

I think it may be Humanigen's management sending a signal ahead of oral arguments scheduled June 2nd. FWIW, if anything. I think there is criminal culpability on the part of the SEC and the FDA and I am watching closely.

How is this even happening with low volume makes no sense

Snapshot:

Symbol
IPIX
Last
$0.0100
Change
+$0.0096 (+2,400.00%)
Bid
$0.0000
Ask
$0.0000
High
$0.0100
Low
$0.0100
Volume
1,000
Time (ET)
11:05:05 AM

On the plus side daptomycin actually works in several indications, has several successful phase III trials to its name and is available for use in several countries.

None of the above apply to brilacidin.

The kicker, though, may be that the CEO of the company that is responsible for daptomycin (Pfizer) has neither stolen every last cent of his shareholders’ money nor gone to ground for several years.

Leo Ehrlich, however, has done both of those things.

For daptomycin, the important established toxicities are:
• CPK elevation / myopathy (muscle injury)
• risk of rhabdomyolysis in severe cases
• eosinophilic pneumonia (rare but potentially serious)
• peripheral neuropathy reported
• infusion reactions
• GI symptoms and liver enzyme elevations
Because of the muscle risk, patients on daptomycin often get weekly creatine phosphokinase (CPK) labs.

dapto’s profile is considerably worse

“ yep mostly mild and transient”

The word “mostly” is doing a lot of work there, especially as brilacidin was literally worse than nothing.

yep mostly mild and transient

If I cursed like that, I'd be suspended for a month.....

" Brilacidin has shown efficacy against SARS-CoV-2 (COVID-19)....... in vitro."

But when administered to humans along with standard of treatment, brilacidin not only delayed their recovery compared to standard of treatment alone, it added nasty side effects of peripheral neuropathy and hypertensive spikes:

https://clinicaltrials.gov/study/NCT04784897?term=brilacidin&viewType=Card&rank=3&tab=results

Which might help to explain why the erstwhile CEO Leo Ehrlich stole all of the shareholders' cash out of the company then went on the lam.

Brilacidin Is dead as is IPIX. End of story.

Hantavirus: it's always funny/annoying when I read about a new virus scare, and then think about "would Brilacidin help in this case?"

Now it's the hantavirus, and let's check...

Brilacidin, a defensin-mimetic drug, has demonstrated broad-spectrum antiviral activity in lab studies against several enveloped, acutely infecting viruses, including bunyaviruses like Rift Valley Fever Virus. It works by targeting both the virus and the host cell, often inhibiting viral entry and disrupting the virion integrity.

Antiviral Range: Brilacidin has shown efficacy against SARS-CoV-2 (COVID-19), alphaviruses (VEEV, EEEV, SINV), and bunyaviruses (RVFV) in vitro.

Hantavirus Connection: While studies show efficacy against Bunyavirales members like RVFV (a bunyavirus), specific studies regarding hantavirus (another bunyavirus) are not highlighted in the available results, though its broad-spectrum action on enveloped viruses is relevant.

“ Where did shareholders money go?”

Florida and Israel.

Filings show:
- a vacuum of capital
- remaining balance sent overseas
- reporting stopped.

Where did shareholders money go?

The cowboy is pretty silent when it comes to answering questions and providing sources for his comments!!!!

The louder the cowboy, the deeper the bullshit. There’s a reason he’s named cowtown.

I'm just curious to know where he gets his information from???? if someone posts something, at least have the courtesy to back it up with something......

Why? False optimism is all that poster offers, catering to those desperate to recover their loses. Don't fall for the lunacy.

Still waiting on the information for the board meeting with Hesai Group and what it has to do with IPIX???? Where is cowtown???????

IPIX is dead. Anyone disagree?

Hesai Group...a Chinese sensor company. Makes no sense. lol

Please educated us on what Hesai Group has to do with IPIX????? This should be entertaining.....

Absolutely nothing to do with IPIX.
Cuckoo.

I had fills on 8 different days going into the end of last month's trading. Some of those days had multiple fills. Schwab reflected higher than expected trading costs on some of those days, which caused me to suspect possible foreign transaction fees, in addition to the regular commissions. That caused me to look for news from Hesai, which I will not be surprised to find at some point. That's where I saw the announced board meeting that I referenced.

"The board of directors (the “Board”) of Hesai Group (the “Company”) hereby announces that a meeting of the Board will be held on May 19, 2026..."

https://www.sec.gov/Archives/edgar/data/1861737/000110465926048977/tm2612803d1_ex99-1.htm

The higher than expected trading costs were adjusted on the following days.

I added a second IPIX sell order this morning. My open sell order expires this week. I may be wrong, but I think having an open sell order enables me to enter a new buy order. FWIW.

Definitely not this failed mess...

Are you referring to some other failed company

That old nutcase imagined it in one of the many delusions swirling around in his lid that are on display in his nonsensical posts. He just makes stuph up from his intestinal gases and posts that twaddle as though it existed anywhere other than in his fever dreams.

His posts are garbage.

Keep trying.

Still no answer from the poster that informed us of the board meeting on may 19th.....just want to know where he saw that?????

Try asking him this: Which board did you intend to post that message on?

If their drugs are as good as the weapons they gave iran, i would recommend against taking them. Looking at the graph in the article, only a true TDS patient would blame Trump. Seek help.

Where did you see an announced board meeting????

IPIX doesn't have a Board meeting scheduled.

Indeed it doesn't have a Board.

Other than that your post is informative and helpful.

Very unusual trading activity and costs. I wonder if it is related to a just-announced Board meeting scheduled for May 19th.

perhaps Leo is taking the IBRX (Dr. Patrick Soon) route and going to Saudi Arabia. Wouldn't that be something!!!!!!

Maybe he's in China, which kicks our ass in science R&D (thanks, Donald).
https://www.aau.edu/newsroom/leading-research-universities-report/its-official-china-tops-us-rd-spending

Nifty. Have you asked AI where Leo Ehrlich is by any chance?

Interesting new delivery method for Brilacidin

From a new study: "Co-Delivery of Cationic Polymeric Sonosensitizer and Antimicrobial Peptide Mimic by Polymeric Nanoparticle for Enhanced Therapy of Lethal Bacterial Pneumonia"
"Pneumonia caused by multidrug-resistant bacteria has emerged as a significant public health concern. To address this issue, this study develops an innovative inhalable polymeric nanoparticle SK5.3, which is constructed by encapsulating a cationic polymeric sonosensitizer CBODI-2 and a cationic antimicrobial peptide mimic BriTE with an anionic, reactive oxygen species (ROS)-sensitive, amphiphilic polymer HSJT. Ultrasound (US) stimulation triggers the sonodynamic effect of CBODI-2 to generate 1O2, which cleaves ROS-sensitive scaffold within HSJT to induce nanoparticle dissociation and cargo release, but also directly cause bacterial killing. Cationic CBODI-2 and BriTE, concurrently released from dissociated SK5.3, target negatively charged bacterial cell surfaces via electrostatic attractions. These enable SK5.3+US to execute a three-mode attack synergistically combining membrane-attacking P+Ph3Br- and BriTE, and sonodynamic effect, demonstrating the potent antibacterial efficacy against Klebsiella pneumoniae and Staphylococcus aureus both in vitro and in vivo. This therapeutic superiority stems from a dual mechanism involving not only direct bactericidal effect but also beneficial host immunomodulation—suppressing inflammation together with promoting injury repair. The nanotherapeutic platform SK5.3+US represents a highly effective strategy for antibiotic-alternative treatment of refractory deep-seated infections."
Source: https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adfm.75611
Published: 04/26/206

BriTE is Brilacidin tetrahydrochloride (BriTE), according to the Google summary where I found the study.

So I asked the AI gods: "This clinical study states it has developed an inhalable polymeric nanoparticle. From the info provided and your best guess, how can I envision this solution, something like a asthma inhaler?"


This is the AI answer:

You are exactly half right! The way the medicine enters the body is very similar to an asthma inhaler, but there is a fascinating, futuristic twist to how the medicine is actually activated once it gets there.

Based on the study abstract, you shouldn't envision a standard quick-puff asthma inhaler that you carry in your pocket. Instead, envision a two-step clinical treatment. Here is how you can picture this solution working in the real world:


Step 1: The Delivery (The "Inhaler" Phase)
Because this treatment is designed for deep-seated pneumonia (severe lung infections), it likely wouldn't be a quick metered-dose inhaler (the classic L-shaped asthma "puffer").

Instead, envision a nebulizer. The patient would wear a mask over their nose and mouth, breathing in a continuous, fine, cloud-like mist for 10 to 15 minutes.

This mist contains the SK5.3 nanoparticles. Think of these nanoparticles as microscopic Trojan Horses. They are tightly packed spheres that are completely inert and harmless while floating through the air and settling deep into the infected pockets of the lungs. Because they have a negative electrical charge, they naturally stick to the surface of the bacteria (which also carry a charge).


Step 2: The Activation (The "Ultrasound" Phase)
This is where the treatment differs entirely from an asthma inhaler. If you only inhale the nanoparticles, nothing happens. They are "locked."

To unlock them, the doctor must use an ultrasound machine.

A technician would place an ultrasound wand on the patient's chest or back, aiming directly at the infected areas of the lungs. The sound waves safely pass through the patient's tissue and hit the nanoparticles waiting inside.


Step 3: The Attack (The Mechanism)
When the ultrasound waves hit the SK5.3 nanoparticles, it triggers a "sonodynamic effect." Here is what happens on a microscopic level:

1. The Burst: The ultrasound energy causes one of the internal ingredients (CBODI-2) to generate reactive oxygen species, specifically singlet oxygen.

2. The Release: This oxygen reaction acts like a chemical detonator, breaking apart the protective polymer shell (HSJT) of the nanoparticle.

3. The Synergistic Kill: The Trojan Horse bursts open, releasing the bacteria-killing payload—the cationic antimicrobial peptide mimic (BriTE) and the chemical $\text{P}^+\text{Ph}_3\text{Br}^-$. These aggressively attack and shred the membranes of the drug-resistant bacteria.

4.The Healing: Simultaneously, this process tells the patient's own immune system to calm down (suppressing harmful inflammation) and start repairing the lung tissue.


In summary: Envision a treatment where a patient first breathes in a high-tech mist through a mask to coat their lungs with microscopic, dormant "smart bombs." Then, a doctor uses an ultrasound wand on their chest to detonate those bombs directly on top of the drug-resistant bacteria.

I get that things change, however if one is out and claims the company is dead, why keep coming back to the gravesite.....isn't time to just move on or am i missing something....

Things change. What once was promising is now garbage. A failed drug pipeline, an incompetent,lying CEO and a company so decimated that it has no cash, no hope and technically, only one person in the entire company. So a changed opinion is completely justified.

Hey Hound, are you still a shareholder, I remember way back when you would sell your kids to buy more IPIX!!!!!