Smilin_B
7年前
ASX RELEASE 4 May 2018
Innate Immunotherapeutics completes acquisition of Amplia Therapeutics
and new Board appointments
Innate Immunotherapeutics Limited (ASX Code: IIL) is pleased to announce that it has today
completed the acquisition of privately owned Melbourne-based biopharmaceutical company Amplia
Therapeutics Pty Ltd (Amplia). As a result of the transaction, the Company will accelerate the
development of Amplia's Focal Adhesion Kinase (FAK) inhibiting drug candidates for application in
immuno-oncology and other indications.
The FAKi candidates AMP886 and AMP945 represent highly attractive compounds for clinical
development possessing excellent potency and drug-like properties, biological selectivity,
bioavailability and manufacturing scale-up potential. Innate has acquired all the shares of Amplia in
exchange for 18,460,308 new ordinary shares issued today by Innate. Following this weeks 10 for 1
share consolidation and the issue of new shares to the Amplia shareholders, Innate now has
41,023,303 shares on issue.
The completion of the Amplia transaction has also occasioned a change in the composition of the
Innate Board. Chris Collins, the Company's previous largest shareholder and director since early
2006, has today retired as a director. "Chris has been a stalwart supporter of Innate for over ten
years and the Company would never have been able to progress the clinical development of our
previous drug candidates without his encouragement and backing. We owe him a very big vote of
thanks." said CEO Simon Wilkinson.
The Company also records its sincere thanks to Elizabeth Hopkins, Andrew Sneddon, and Chairman
Michael Quinn, all of whom are today stepping down from the Board. "Innate's shareholders and our
many other stakeholders have been very well served by this group of committed and very
professional independent directors" said Mr Wilkinson.
Joining the Board’s remaining members Robert Peach and Simon Wilkinson from today are Andrew
Cooke, Chris Behrenbruch, Chris Burns, and Warwick Tong. Mr Cooke, the Company's Secretary since
late 2013, has extensive experience in law, corporate finance, governance and compliance. Mr
Cooke will chair the Company's Audit Committee. Messrs Behrenbruch, Burns, and Tong were
formally directors of Amplia and have a deep knowledge of the FAK assets now owned by Innate.
Each also has over 20 years hands-on experience in the pharmaceutical and biotechnology industry.
Smilin_B
7年前
ELEASE 26 April 2018
Results of General Meeting
Innate Immunotherapeutics Limited (ASX Code: IIL) is pleased to confirm that each of the resolutions
considered at its General Meeting held earlier today were passed.
Results of the General Meeting are summarised as follows:
# RESOLUTION PASSED/
FAILED
VOTE
SoH*/
POLL
PROXIES
FOR
PROXIES
AGAINST
PROXIES
DISCRETION
PROXIES
ABSTAIN
1 Consolidation of Capital Passed SoH 57,087,386 1,048,247 1,344,637 1,210,868
2 Acquisition of Amplia Passed SoH 59,178,282 25,512 1,344,637 142,707
3 Issue of Consideration
Shares to Amplia Passed SoH 59,112,491 60,892 1,344,637 173,118
4 Appointment of Andrew
Cooke as a Director Passed SoH 58,858,276 61,431 1,398,504 372,927
5 Appointment of Christian
Behrenbruch as a Director Passed SoH 58,376,787 675,512 1,398,504 240,335
6 Appointment of Warwick
Tong as a Director Passed SoH 58,432,754 691,929 1,342,537 223,918
7 Appointment of Christopher
Burns as a Director Passed SoH 58,367,754 675,512 1,407,537 240,335
*Show of Hands
For Further Information:
Mr Simon Wilkinson, CEO
+64 21 661 850
or visit the Innate Immunotherapeutics website at www.innateimmuno.com
makinezmoney
7年前
$INNMF: NEWS... Acquisition of 100% of AMPLIA-therapeutics
http://www.innateimmuno.com/irm/PDF/1462_0/FocusonImmunoOncologyampAcquisitionof2DrugCandidates
ASX RELEASE 23 March 2018
Innate Immunotherapeutics refocuses on immuno-oncology and announces
acquisition of two novel cancer drug candidates
https://stockhead.com.au/health/innate-switches-cancer-failed-ms-bid-shares-rocket-148pc/
Innate Immunotherapeutics Limited (ASX Code: IIL) is pleased to announce that it has entered into a
conditional agreement with the shareholders of Amplia Therapeutics Pty Ltd (Amplia) to acquire all
of the shares of Amplia in consideration for the issue of Innate ordinary shares. In acquiring Amplia,
Innate will acquire that company's Focal Adhesion Kinase (FAK) cancer programme. FAK is emerging
as a promising target in cancer therapy.
"Prior to the Company's recently terminated clinical development of MIS416 for multiple sclerosis,
we were also positioning our immune modulating drug as a potential anti-cancer co-therapy" said
Innate's CEO Simon Wilkinson. "In parallel with our MS programme, we monitored the rapid
developments in the immuno-oncology field and continued to support various long running
collaborations in the cancer co-therapy space." "Refocusing on this existing area of our business is a
logical move for the Company and we are particularly excited to be pursuing certain cancers where
the immune system could play an important role in successful treatment strategies" said Mr
Wilkinson.
Amplia has in-licensed two FAK targeting drug candidates (currently referred to as AMP886 and
AMP945) from Cancer Research Technology Limited, a wholly owned subsidiary of Cancer Research
UK. The drug candidates were originally developed by the Melbourne based Cancer Therapeutics
Cooperative Research Centre (CTx). The CRC Program, is an Australian Government initiative
supporting end-user driven research collaborations to address the major challenges facing Australia.
"There have been multiple independent high-quality publications suggesting that the successful
targeting of FAK could increase the efficacy of other immuno-oncology therapies in tumours where
to date they have limited anti-tumour effects as single agents" said Innate director Dr Robert Peach
who led the Company's technical review of the drug candidates. "CTx have done an excellent job
selecting and characterizing AMP886 and AMP945 before licensing them to Cancer Research
Technology Limited. I was impressed at the thoroughness of their work".
Amplia is a privately owned Melbourne-based biopharmaceutical company. Subject to approval by
the shareholders of both Innate and Amplia, Innate will acquire all the shares of Amplia in exchange
for new ordinary shares to be issued by Innate. Following settlement, Amplia shareholders will own
45% of the total issued capital of Innate and Innate expects to have approximately $2 million cash in
hand and no debt. The Board and management of the Company will include representatives from
the current Innate team and the Amplia team.
In the short term and using existing financial resources, the Company will focus on reviewing
opportunities for MIS416 and advancing the preclinical development of at least one of the two
Amplia drug candidates with a view to being 'Phase 1 ready' within approximately 12 months.
Shareholder approval of the proposed transaction will be sought at a General Meeting to be held at
11am on Thursday 26th April at Level 17, 383 Kent St, Sydney. Shareholder approval will also be
sought for a ten into one consolidation of the issued capital of the Company. The Notice of Meeting
for this General Meeting is expected to be despatched on Wednesday 28th March.
Attached to this announcement are further details concerning the proposed transaction, as required
by ASX Listing Rule 11.1.
- End
For Further Information:
Mr Simon Wilkinson
Managing Director and CEO
Email: simon@innateimmuno.com