Anadis Launches Products to Reduce Global Childhood Diarrhea Deaths - Oral Rotavirus & E.coli Antibodies
2008年3月11日 - 1:00AM
ビジネスワイヤ(英語)
Anadis Ltd. (ASX:ANX; OTC: ANDIY) an Australian biopharmaceutical
company announced today the in-licensing of GastroGard-R, an
all-natural orally administered formulation containing specific
antibodies proven to reduce rotavirus virus diarrhea in young
children. The license allows Anadis to exclusively supply
humanitarian agencies worldwide as well as to enter large national
markets including India, Korea, Indonesia and Australia, with other
countries expected to be added based on demand. GastroGard-R is
positioned to complement global rotavirus virus vaccine initiatives
and reduces overall morbidity and mortality from this terrible
disease. The announcement was made at the Partnering for Global
Health Forum 2008 (http://pgh.bio.org) being held in Washington
D.C. Each year more than 600,000 children die from rotavirus-caused
diarrhea and another two million children are hospitalized,
predominantly in developing countries (WHO). The virus is spread
through exposure to contaminated food and water. Before age five,
every child in the world will suffer at least one episode of
rotavirus disease, a condition associated with diarrhea, fever and
vomiting. The CDC estimates 55,000 children each year in the United
States are hospitalized because of rotavirus diarrhea, and that
rotavirus is the most common cause of severe diarrhea in children.
GastroGard-R provides prophylactic treatment of at -risk children
aged one month to three years to prevent diarrhea due to rotavirus.
Rotavirus is very infectious in young children and outbreaks occur
frequently during winter in hospitals, daycare centers, and in the
family setting. Two vaccines have been licensed in the global
effort to prevent rotavirus diarrhea related morbidity, Merck�s
RotaTeq (NYSE: MRK) and GlaxoSmithKline�s RotaRix (NYSE: GSK) while
several global partnerships have been established, involving
non-profit agencies, the CDC and the World Health Organization, to
reduce the costs of deploying these expensive vaccines.
GastroGard-R is positioned to complement vaccine initiatives as
part of this worldwide disease control effort. Providing
immediate-acting (so-called �passive�) immunity by oral means is
especially important for the millions of children without access to
these new vaccines, such as children who are too young or old to
receive vaccine priority, as well as children at risk from epidemic
disease spread in refugee camps, hospitals or daycare centers.
GastroGard-R is a non-sterile, oral powder, consisting of the
concentrated proteins, including immunoglobulins, from the pre-milk
(colostrum) of hyper-immunised cows. The primary immunoglobulin in
the formulation is IgG1. GastroGard-R has been studied extensively
and has been in use throughout Australia for many years but has not
been commercialized globally until now. Six hospital-based clinical
studies were performed with GastroGardR, four in Australia and two
in other countries. Five of these studies were randomized, double
blind, placebo-controlled design and the other study was open.
Patients were aged from 28 days to three (3) years and combined
analysis of these studies demonstrated a statistically significant
reduction in the incidence of rotavirus infection in children given
GastroGard-R compared with children not given GastroGard-R� (p
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