As
filed with the Securities and Exchange Commission on September 3, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-3
REGISTRATION
STATEMENT
UNDER
THE SECURITIES
ACT OF 1933
ZURA BIO LIMITED
(Exact name of registrant as specified in its
charter)
Cayman
Islands
(State or other jurisdiction
of incorporation or
organization) |
2834
(Primary Standard Industrial
Classification Code Number) |
98-172573
(I.R.S. Employer Identification
Number) |
1489 W. Warm Springs Rd. #110
Henderson, NV 89014
Tel: (702) 825-9872
(Address, including zip code, and telephone
number, including area code, of registrant’s principal executive offices)
Robert Lisicki
1489 W. Warm Springs Rd. #110
Henderson, NV 89014
Tel: (702) 825-9872
(Name, address, including zip code, and telephone
number, including area code, of agent for service)
Copies to:
Divakar
Gupta
Sarah Sellers
Brandon Fenn
Cooley LLP
55 Hudson Yards
New York, NY 10001
Tel: (212) 479-6000 |
Robert
Lisicki
1489 W. Warm Springs Rd. #110
Henderson, NV 89014
Tel: (702) 825-9872
|
From time to time after the effective date
of this Registration Statement
(Approximate date of commencement of proposed
sale to the public)
If
the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please
check the following box. ¨
If
any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415
under the Securities Act of 1933, as amended, other than securities offered only in connection with dividend or interest reinvestment
plans, check the following box. x
If
this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act,
please check the following box and list the Securities Act registration statement number of the earlier effective registration statement
for the same offering. ¨
If
this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box
and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨
If
this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become
effective upon filing with the Securities and Exchange Commission pursuant to Rule 462(e) under the Securities Act, check the
following box. ¨
If
this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register
additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following
box. ¨
Indicate by check mark whether
the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging
growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting
company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large
accelerated filer ¨ |
Accelerated
filer ¨ |
Non-accelerated
filer x |
Smaller reporting
company x |
|
Emerging growth
company x |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities
Act. ¨
The Registrant hereby amends this Registration
Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment that
specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Securities and Exchange
Commission, acting pursuant to said Section 8(a), may determine.
EXPLANATORY NOTE
This
registration statement contains the following documents:
| · | a
base prospectus which covers the offering, issuance and sale by us of up to a maximum aggregate
offering price of $300,000,000 of ordinary shares, preference shares, debt securities, warrants
and/or units from time to time in one or more offerings; and |
| · | a
sales agreement prospectus covering the offering, issuance and sale by us of up to a maximum
aggregate offering price of $125,000,000 of our Class A ordinary shares, par value $0.0001
per share (“Class A Ordinary Shares”), that may be issued and sold under
a sales agreement, dated September 3, 2024, with Leerink Partners (the “Sales Agreement”). |
The
base prospectus immediately follows this explanatory note. The specific terms of any securities to be offered pursuant to the base prospectus
other than the shares under the Sales Agreement will be specified in a prospectus supplement to the base prospectus. The specific terms
of the securities to be issued and sold under the Sales Agreement are specified in the sales agreement prospectus that immediately follows
the base prospectus. The $125,000,000 of Class A Ordinary Shares that may be offered, issued and sold under the sales agreement
prospectus is included in the $300,000,000 of securities that may be offered, issued and sold by the registrant under the base prospectus.
Upon termination of the Sales Agreement, any portion of the $125,000,000 included in the sales agreement prospectus that is not sold
pursuant to the Sales Agreement will be available for sale in other offerings pursuant to the base prospectus, and if no Class A
Ordinary Shares are sold under the Sales Agreement, the full $300,000,000 of securities may be sold in other offerings pursuant to the
base prospectus and a corresponding prospectus supplement.
The information in this prospectus
is not complete and may be changed. We may not sell these securities or accept an offer to buy these securities until the registration
statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and
it is not soliciting offers to buy these securities in any state where such offer or sale is not permitted.
SUBJECT TO COMPLETION, DATED
SEPTEMBER 3, 2024
PROSPECTUS
ZURA BIO LIMITED
$300,000,000
Class A Ordinary Shares
Preferred Shares
Debt Securities
Warrants
Units
From time to time, we may offer and sell up to $300,000,000 in the
aggregate of our Class A ordinary shares, par value $0.0001 per share (the “Class A Ordinary
Shares”), preferred shares, debt securities, warrants and/or units to purchase any of such securities, described in this
prospectus, either individually or in combination with other securities or in units, in one or more offerings. We may also offer securities
as may be issuable upon conversion, redemption, repurchase, exchange or exercise of any securities registered hereunder, including any
applicable antidilution provisions.
This prospectus provides
a general description of the securities we may offer. As may be required, each time we offer and sell securities, we will file a prospectus
supplement to this prospectus that contains specific information about the offering and, if applicable, the amounts, prices and terms
of the securities offered. We may also authorize one or more free writing prospectuses to be provided to you in connection with these
offerings. The prospectus supplement and any related free writing prospectus may also add, update or change information contained in
this prospectus. You should carefully read this prospectus, the applicable prospectus supplement and any related free writing prospectus,
as well as any documents incorporated by reference, before you invest in any of the securities being offered.
This prospectus may not be used to consummate
a sale of any securities unless accompanied by a prospectus supplement.
Our
Class A Ordinary Shares are currently listed on the Nasdaq Capital Market (“Nasdaq”) under the symbol “ZURA”.
On August 30, 2024, the last reported sales price of our Class A Ordinary Shares was $4.13 per share. The applicable prospectus
supplement will contain information, where applicable, as to any other listing on Nasdaq or any securities market or other exchange of
the securities, if any, covered by the applicable prospectus supplement.
We may offer and sell the
securities described in this prospectus and any prospectus supplement directly to investors, through agents designated from time to time
or to or through underwriters or dealers, on a continuous or delayed basis. For additional information on the methods of sale, you should
refer to the section entitled “Plan of Distribution” in this prospectus. If any agents or underwriters are involved in the
sale of any securities with respect to which this prospectus is being delivered, the names of such agents or underwriters and any applicable
fees, commissions, discounts or options to purchase additional securities will be set forth in a prospectus supplement. The price to
the public of such securities and the net proceeds we expect to receive from such sale will also be set forth in a prospectus supplement.
We are an “emerging growth company”
as defined by the Jumpstart Our Business Startups Act of 2012, and as such, have elected to comply with reduced public company reporting
requirements for this prospectus and the documents incorporated by reference herein and may elect to comply with reduced public company
reporting requirements in future filings.
Investing
in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the heading
“Risk Factors” on page 6 of this
prospectus as well as those contained in the applicable prospectus supplement and any related free writing prospectus, and under similar
headings in the other documents that are incorporated by reference into this prospectus.
NEITHER THE SECURITIES AND EXCHANGE COMMISSION
NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE.
ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
The date of this prospectus is ,
2024.
TABLE OF CONTENTS
ABOUT
THIS PROSPECTUS
This prospectus is part
of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission (the “SEC”) using
the “shelf” registration process. Under this shelf registration process, we may, from time to time, issue, offer and sell,
as applicable, any combination, either individually or in units, of the securities described in this prospectus in one or more offerings from time to time up to a total
aggregate offering price of $300,000,000 through any means described in the section titled “Plan of Distribution.”
A prospectus supplement
may also add, update, or change information included in this prospectus. Any statement contained in this prospectus will be deemed to
be modified or superseded for purposes of this prospectus to the extent that a statement contained in such prospectus supplement modifies
or supersedes such statement. Any statement so modified will be deemed to constitute a part of this prospectus only as so modified, and
any statement so superseded will be deemed not to constitute a part of this prospectus. You should rely only on the information contained
in this prospectus, any applicable prospectus supplement or any related free writing prospectus. See “Where You Can Find More
Information” and “Incorporation by Reference.”
We have not authorized any
other person to provide you with different or additional information. If anyone provides you with different or additional information,
you should not rely on it. We may only offer to sell, and seek offers to buy, any securities in jurisdictions where offers and sales
are permitted.
This prospectus incorporates
by reference, and any prospectus supplement or free writing prospectus may contain and incorporate by reference, certain market and industry
data obtained from independent market research, industry publications and surveys, governmental agencies and publicly available information.
Industry surveys, publications and forecasts generally state that the information contained therein has been obtained from sources believed
to be reliable, although they do not guarantee the accuracy or completeness of such information. We believe the data from such third-party
sources to be reliable. However, we have not independently verified any of such data and cannot guarantee its accuracy or completeness.
Similarly, internal market research and industry forecasts, which we believe to be reliable based upon our management’s knowledge
of the market and the industry, have not been verified by any independent sources. While we are not aware of any misstatements regarding
the market or industry data presented herein, our estimates involve risks and uncertainties and are subject to change based on various
factors.
You should not assume that
the information contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate
on any date subsequent to the date set forth on the front of the document or that any information we have incorporated by reference is
correct on any date subsequent to the date of the document incorporated by reference, even though this prospectus, any applicable prospectus
supplement or any related free writing prospectus is delivered, or securities are sold, on a later date.
Unless otherwise stated,
the terms “we,” “us,” “our” and “Zura” refer to Zura Bio Limited, a Cayman Islands exempted
company (formerly known, prior to the Business Combination, as JATT Acquisition Corp), or its affiliates.
MARKET
AND INDUSTRY DATA
Certain
information contained in this document relates to or is based on studies, publications, surveys and other data obtained from third-party
sources and our own internal estimates and research. While we believe these third-party sources to be reliable as of the date of this
prospectus, we have not independently verified the market and industry data contained in this prospectus or the underlying assumptions
relied on therein. Finally, while we believe our own internal research is reliable, such research has not been verified by any independent
source. Notwithstanding the foregoing, we are liable for the information provided in this prospectus.
TRADEMARKS
This
document contains references to trademarks, trade names and service marks belonging to other entities. Solely for convenience, trademarks,
trade names and service marks referred to in this prospectus may appear without the ®
or TM symbols, but such references are not intended to indicate, in any way, that the applicable
owner or licensor will not assert, to the fullest extent under applicable law, its rights to these trademarks and trade names. We do
not intend our use or display of other companies’ trade names, trademarks or service marks to imply a relationship with, or endorsement
or sponsorship of us by, any other companies.
CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus and the documents incorporated by reference herein and any prospectus supplement delivered with this prospectus contain forward-looking
statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. This includes,
without limitation, statements regarding our financial position, business strategy, our objectives, plans, expectations and assumptions.
In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including
any underlying assumptions, are forward- looking statements. The words “anticipate,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,”
“possible,” “potential,” “predict,” “project,” “should,” “will,”
“would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that
a statement is not forward-looking.
The forward-looking statements
are based on the current expectations of the Company and its management thereof and are inherently subject to uncertainties and changes
in circumstances and their potential effects and speak only as of the date of such statement. There can be no assurance that future developments
will be those that have been anticipated. These forward-looking statements involve a number of risks, uncertainties or other assumptions
that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements.
These risks and uncertainties include, but are not limited to:
| · | our
expectations regarding our product candidates and their related benefits, and our beliefs
regarding competing product candidates and products both in development and approved, may
not be achieved; |
| · | our
vision and strategy may not be successful; |
| · | the
timing of key events and initiation of our studies and release of clinical data may take
longer than anticipated or may not be achieved at all; |
| · | expectations
regarding the potential general acceptability and maintenance of our product candidates by
regulatory authorities, payors, physicians, and patients may not be achieved; |
| · | we
may be unable to attract and retain key personnel; |
| · | expectations
with respect to our future operating expenses, capital requirements and needs for additional
financing may not be achieved; |
| · | we
have not completed any clinical trials, and have no products approved for commercial sale; |
| · | we
have incurred significant losses since inception, and expect to incur significant losses
for the foreseeable future and may not be able to achieve or sustain profitability in the
future; |
| · | we
require substantial additional capital to finance our operations, and if we are unable to
raise such capital when needed or on acceptable terms, we may be forced to delay, reduce,
and/or eliminate one or more of our development programs or future commercialization efforts; |
| · | we
may be unable to renew existing contracts or enter into new contracts; |
| · | we
rely on third-party contract development manufacturing organizations for the manufacture
of clinical materials; |
| · | we
rely on contract research organizations, clinical trial sites, and other third parties to
conduct our preclinical studies and clinical trials; |
| · | we
may be unable to obtain regulatory approval for our product candidates, and there may be
related restrictions or limitations of any approved products; |
| · | we
may be unable to successfully respond to general economic and geopolitical conditions; |
| · | we
may be unable to effectively manage growth; |
| · | we
face competitive pressures from other companies worldwide; |
| · | we
may be unable to adequately protect our intellectual property rights; |
| · | our
expectations regarding the use of proceeds from offerings of our securities under this prospectus;
and |
| · | other
factors set forth in documents filed, or to be filed, with the SEC. |
Additional
discussion of the risks, uncertainties and other factors described above, as well as other risks material to our business, can be found
in the section titled “Risk Factors” contained elsewhere in this prospectus and in any applicable prospectus supplement,
any free writing prospectuses we may authorize for use in connection with a specific offering, and in our most recent Annual Report on
Form 10-K and in our most recent Quarterly Report on Form 10-Q, as well as any amendments thereto reflected in subsequent filings
with the SEC, which are incorporated by reference into this prospectus in their entirety. We may not actually achieve the plans,
intentions or expectations disclosed in our forward-looking statements. New risk factors emerge from time to time and it is not possible
to predict all such risk factors, nor can we assess the impact of all such risk factors on our business or the extent to which any factor
or combination of factors may cause actual results to differ materially from those contained in any forward-looking statements. Our forward-looking
statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures, investments or other
transactions we may execute.
Forward-looking statements
are not guarantees of performance. You should not put undue reliance on our forward-looking statements. Forward-looking statements, reflect
our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this
prospectus, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete,
and statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available
relevant information. All forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their
entirety by the foregoing cautionary statements. We undertake no obligation to update or revise publicly any forward-looking statements,
whether as a result of new information, future events or otherwise, except as required by law.
PROSPECTUS
SUMMARY
This summary highlights
selected information included in this prospectus or incorporated by reference in this prospectus, and does not contain all of the information
that may be important to you in making an investment decision. This summary is qualified in its entirety by the more detailed information
included in this prospectus. Before making your investment decision with respect to our Class A Ordinary Shares, you should carefully
read this entire prospectus, including the information under “Risk Factors” contained in this prospectus and any applicable
prospectus supplement, and under similar headings in the other documents that are incorporated by reference in this prospectus. You should
also carefully read the information incorporated by reference into this prospectus, including our financial statements, and exhibits
to the registration statement of which this prospectus is a part. Unless the context indicates otherwise, references in this prospectus
to “Zura,” “Company,” “we,” “us,” “our” and similar terms prior are intended
to refer to Zura Bio Limited and its consolidated subsidiaries, and references in this prospectus to the “Board of Directors”
or “Zura Board” are intended to refer to the board of directors of Zura Bio Limited.
Overview
Zura Bio Limited, formerly
known as JATT Acquisition Corp, is a multi-asset clinical-stage biotechnology company focused on developing novel medicines for immune
and inflammatory disorders. With its experienced leadership team, Zura aims to become a leader in the autoimmune and inflammatory field.
We are currently developing
three clinical-stage product candidates to address indications with high unmet needs and significant commercial opportunity.
| · | Tibulizumab
(ZB-106) is an IgG-scFv bispecific dual-antagonist antibody engineered by the fusion of elements
of TALTZ® (ixekizumab) and tabalumab that neutralizes IL-17A and BAFF. These cytokines
play pivotal roles in various inflammatory and autoimmune disorders. By targeting IL-17A
and BAFF, tibulizumab demonstrates potential in mitigating chronic inflammation while preserving
immune system integrity. Three Phase 1/1b clinical studies have been completed with tibulizumab
to date, including in participants with rheumatoid arthritis and Sjögren’s syndrome. |
| · | Crebankitug
(ZB-168) is a fully human, high affinity monoclonal antibody that binds and neutralizes the
IL-7 receptor chain (IL-7R) alpha. IL-7Rα sits at the nexus of two key immune pathways, IL-7
and thymic stromal lymphopoietin (TSLP), thus IL-7Rα has the potential to block activation
through either of these pathways. As a result, we believe crebankitug could be therapeutically
relevant in a broad set of indications where the IL-7 or TSLP pathways may be involved. Three
Phase 1/1b clinical studies have been conducted to date. There are additional IL-7Rα
inhibitors under development for conditions like alopecia areata, atopic dermatitis, and
ulcerative colitis. We are actively assessing the competitive landscape and evaluating potential
therapeutic indications to guide our future development efforts for crebankitug. |
| · | Torudokimab
(ZB-880) is a fully human, high affinity monoclonal antibody that neutralizes IL-33, preventing
ST2-dependent and ST2-independent (e.g., RAGE) inflammation. The IL-33/ST2 axis stands as
a validated therapeutic target for conditions such as chronic obstructive pulmonary disease
(COPD) and asthma. Three Phase 1/2 clinical studies have been conducted to date. We are actively
assessing the competitive landscape and evaluating potential therapeutic indications to guide
our future development efforts for torudokimab. |
The Business Combination
We were originally known
as JATT Acquisition Corp. On March 20, 2023 (the “Closing Date”), Zura Bio Limited, a limited company incorporated under
the laws of England and Wales (“Legacy Zura”), JATT Acquisition Corp, a Cayman Islands exempted company (“JATT”),
JATT Merger Sub, a Cayman Islands exempted company and wholly owned subsidiary of JATT (“Merger Sub”), JATT Merger Sub 2,
a Cayman Islands exempted company and wholly owned subsidiary of JATT (“Merger Sub 2”) and Zura Bio Holdings Ltd, a Cayman
Islands exempted company (“Holdco”), consummated the closing of the transactions contemplated by the Business Combination
Agreement dated June 16, 2022, as amended on September 20, 2022, November 14, 2022 and January 13, 2023, by and among
Legacy Zura, JATT, Merger Sub, Merger Sub 2 and Holdco (the “Business Combination Agreement”), following the approval at
an extraordinary general meeting of JATT’s shareholders held on March 16, 2023 (the “Extraordinary General Meeting”
and the consummation of such transactions, the “Closing”).
The Business Combination
generated approximately $56.7 million in net proceeds. On March 21, 2023, the Company’s Class A Ordinary Shares began
trading on the Nasdaq under the symbol “ZURA”.
Stock Exchange Listing
Zura’s Class A
Ordinary Shares are currently listed on Nasdaq under the symbol “ZURA”.
Corporate Information
Our
principal executive offices are located at Zura’s principal executive offices are located at 1489 W. Warm Springs Road,
#110, Henderson, Nevada and our telephone number is (702) 825-9872. Our corporate website address is www.zurabio.com. Information
contained on or accessible through our website is not a part of this prospectus, and the inclusion of our website address in this prospectus
is an inactive textual reference only.
Emerging Growth Company
We are an “emerging
growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our Business Startups
Act of 2012 (the “JOBS Act”), and we may take advantage of certain exemptions from various reporting requirements that are
applicable to other public companies that are not emerging growth companies, including, but not limited to, not being required to comply
with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley
Act”), reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements, and exemptions
from the requirements of holding a nonbinding advisory vote on executive compensation and shareholder approval of any golden parachute
payments not previously approved.
Further, Section 102(b)(1) of
the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting standards until
private companies (that is, those that have not had a Securities Act registration statement declared effective or do not have a class
of securities registered under the Exchange Act) are required to comply with the new or revised financial accounting standards. The JOBS
Act provides that a company can elect to opt out of the extended transition period and comply with the requirements that apply to non-emerging
growth companies but any such election to opt out is irrevocable.
We will remain as an emerging
growth company until the earlier of: (i) the last day of the fiscal year (a) following the fifth anniversary of the closing
of JATT’s IPO, (b) in which we have total annual gross revenue of at least $1.235 billion, or (c) in which we are deemed
to be a large accelerated filer, which means the market value of our common equity that is held by non-affiliates exceeds $700 million
as of the last business day of its most recently completed second fiscal quarter; and (ii) the date on which we have issued more
than $1.235 billion in non-convertible debt securities during the prior three-year period. References herein to “emerging growth
company” have the meaning associated with it in the JOBS Act.
Smaller Reporting Company
Additionally, we are currently
a “smaller reporting company” as defined in Item 10(f)(1) of Regulation S-K. Smaller reporting companies may take
advantage of certain reduced disclosure obligations, including, among other things, providing only two years of audited financial
statements. We may continue to be a smaller reporting company if either (i) the market value of our stock held by non-affiliates is
less than $250 million or (ii) our annual revenue is less than $100 million during the most recently completed fiscal year
and the market value of our stock held by non-affiliates is less than $700 million.
RISK
FACTORS
An investment in our securities
involves a high degree of risk. In addition to the risks and uncertainties discussed above under “Cautionary Note Regarding Forward-Looking
Statements,” you should carefully consider the risk factors incorporated by reference to our most recent Annual Report on Form 10-K,
any subsequent Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, and all other information contained or incorporated
by reference into this prospectus, as updated by our subsequent filings under the Exchange Act, and the risk factors and other information
contained in any applicable prospectus supplement, before making an investment decision. Our business, prospects, financial condition
or operating results could decline due to any of these risks and, as a result, you may lose all or part of your investment. The occurrence
of any of these risks might cause you to lose all or part of your investment in the offered securities. We may face additional risks
and uncertainties that are not presently known to us, or that we currently deem immaterial.
USE
OF PROCEEDS
Unless otherwise set forth
in a prospectus supplement or any related free writing prospectus that we may authorized to be provided to you, we currently intend to
use the net proceeds of any offering of securities for working capital and other general corporate purposes. Accordingly, we will have
significant discretion in the use of any net proceeds. We will set forth in the applicable prospectus supplement or free writing prospectus
our intended use for the net proceeds received from the sale of any securities sold pursuant to the prospectus supplement or free writing
prospectus. Pending the use of net proceeds, we intend to invest the net proceeds in short-term, investment-grade, interest bearing obligations,
certificates of deposit or direct or guaranteed obligations of the United States government.
SECURITIES
WE MAY OFFER
This prospectus contains
summary descriptions of the securities we may offer from time to time. These summary descriptions are not meant to be complete descriptions
of each security. The particular terms of any security will be described in the applicable prospectus supplement.
DESCRIPTION
OF SHARES
We are a company incorporated
in the Cayman Islands as an exempted company and our affairs are governed by our Second Amended and Restated Memorandum and Articles
of Association (the “MAA”), the Cayman Islands Companies Act and the common law of the Cayman Islands. Pursuant to the MAA,
our authorized share capital is $30,100 divided into 300,000,000 Zura Class A Ordinary Shares of a par value of $0.0001 each, no
Class B Ordinary Shares of a par value of $0.001 each, and 1,000,000 preference shares of a par value of $0.0001 each. The following
description summarizes certain terms of our shares as set out more particularly in the MAA. Because it is only a summary, it may not
contain all the information that is important to you.
Ordinary Shares
As of August 29, 2024, we
have 63,774,183 Class A Ordinary Shares outstanding. Our shareholders of record are entitled to one vote for each share held on all
matters to be voted on by shareholders.
The members of our Board
of Directors serve until the next annual general meeting. There is no cumulative voting with respect to the appointment of directors,
with the result that the holders of more than 50% of the shares eligible to vote for the appointment of directors and voting at the applicable
meeting can appoint all of the directors. Subject to the rights of any holders of preference shares to appoint directors, the number
of directors that shall constitute the Zura Board shall be as determined from time to time exclusively by the Zura Board.
Directors
may only be removed for cause by a majority of the other directors then in office or by the affirmative vote of at least two-thirds (662∕3%)
of the voting power of all then-outstanding shares of Zura entitled to vote thereon, voting together as a single class.
Our shareholders have no
conversion, preemptive or other subscription rights and there are no sinking fund or redemption provisions applicable to the ordinary
shares.
Register of Members
Under Cayman Islands law,
we must keep a register of members and there will be entered therein:
| · | the
names and addresses of the members, a statement of the shares held by each member, and of
the amount paid or agreed to be considered as paid, on the shares of each member and the
voting rights of the shares of each member; |
| · | whether
voting rights are attached to the shares in issue; |
| · | the
date on which the name of any person was entered on the register as a member; and |
| · | the
date on which any person ceased to be a member. |
Under Cayman Islands law,
the register of members of our company is prima facie evidence of the matters set out therein (i.e. the register of members will raise
a presumption of fact on the matters referred to above unless rebutted) and a member registered in the register of members will be deemed
as a matter of Cayman Islands law to have legal title to the shares as set against its name in the register of members. However, there
are certain limited circumstances where an application may be made to a Cayman Islands court for a determination on whether the register
of members reflects the correct legal position. Further, the Cayman Islands court has the power to order that the register of members
maintained by a company should be rectified where it considers that the register of members does not reflect the correct legal position.
If an application for an order for rectification of the register of members were made in respect of our shares, then the validity of
such shares may be subject to re-examination by a Cayman Islands court.
Founder Shares
Founder Shares were outstanding
JATT Class B Ordinary Shares that automatically converted into Zura Class A Ordinary Shares at the Closing on a one-for-one
basis, subject to adjustment. The Founder Shares are henceforth identical to the other Zura Class A Ordinary Shares, and holders
of Founder Shares have the same shareholder rights as public shareholders, except that (i) the Founder Shares are subject to certain
transfer restrictions, as described in more detail below and (ii) the Founder Shares are entitled to registration rights.
With certain limited exceptions,
the Founder Shares are not transferable, assignable or salable (except to permitted transferees, each of whom will be subject to the
same transfer restrictions) until the earlier of (A) six months after the completion of the Business Combination or (B) subsequent
to the Business Combination, (x) if the reported closing price of our Zura Class A Ordinary Shares equals or exceeds $12.00
per share (as adjusted for share sub-divisions, share dividends, reorganizations, recapitalizations and the like) for any 20 trading days
within any 30-trading day period commencing at least 150 days after the Business Combination or (y) the date, following the
completion of the Business Combination, on which we complete a liquidation, merger, capital share exchange, reorganization or other similar
transaction that results in all of our shareholders having the right to exchange their ordinary shares for cash, securities or other
property.
Preference Shares
Our MAA provide that preference
shares may be issued from time to time in one or more series. Our Board of Directors are authorized to fix the voting rights, if any,
designations, powers, preferences, the relative, participating, optional or other special rights and any qualifications, limitations
and restrictions thereof, applicable to the shares of each series. Our Board of Directors are able to, without shareholder approval,
issue preference shares with voting and other rights that could adversely affect the voting power and other rights of the holders of
the Class A ordinary shares and could have anti-takeover effects. The ability of our Board of Directors to issue preference shares
without shareholder approval could have the effect of delaying, deferring or preventing a change of control of us or the removal of existing
management. We have no preference shares outstanding at the date hereof, and do not expect to have any preference shares outstanding
immediately following consummation of the Business Combination. Although we do not currently intend to issue any preference shares, we
cannot assure you that we will not do so in the future. No preference shares were issued or registered in connection with the Business
Combination.
Registration Rights
March 2023 A&R Registration Rights
Agreement
On March 20, 2023,
in connection with and effective upon the consummation of the Business Combination, Zura, the Sponsor and certain other parties entered
into the A&R Registration Rights Agreement at the Closing, pursuant to which they agreed to register for resale certain Class A
Ordinary Shares and other equity securities that are held by parties thereto from time to time. The A&R Registration Rights Agreement
includes customary demand and piggyback registration rights.
With certain limited exceptions,
certain of our Class A Ordinary Shares held by parties to the A&R Registration Rights Agreement are not transferable, assignable
or salable (except to permitted transferees, each of whom will be subject to the same transfer restrictions) until the earlier of (A) six months
after the completion of the Business Combination or (B) subsequent to the Business Combination, (x) if the reported closing
price of our Zura Class A Ordinary Shares equals or exceeds $12.00 per share (as adjusted for share sub-divisions, share dividends,
reorganizations, recapitalizations and the like) for any 20 trading days within any 30-trading day period commencing at least 150 days
after the Business Combination or (y) the date, following the completion of the Business Combination, on which we complete a liquidation,
merger, capital share exchange, reorganization or other similar transaction that results in all of our shareholders having the right
to exchange their Class A ordinary shares for cash, securities or other property.
April 2023 Private Placement
Under the terms of the subscription
agreements entered into with the investors (the “2023 Subscribers”) in the April 2023 Private Placement (the “2023
PIPE Subscription Agreements”), the Company agreed to prepare and file, within 45 days after the closing of the April 2023
Private Placement (the “2023 Filing Deadline”), one or more registration statements (each a “2023 PIPE Registration
Statement”) with the SEC to register for resale the Class A Ordinary Shares (the “2023 PIPE Shares”) issued under
the 2023 PIPE Subscription Agreements and the Class A Ordinary Shares issuable upon exercise of the pre-funded warrants (the “2023
Pre-Funded Warrants”) issued to purchase up to 3,782,000 Class A Ordinary Shares (the “2023 Warrant Shares”) issued
pursuant to the 2023 PIPE Subscription Agreements, and to cause the applicable 2023 PIPE Registration Statement(s) to become effective
within a specified period after the 2023 Filing Deadline. The Company also agreed to use its best efforts to keep such 2023 PIPE Registration
Statement effective until the earlier of (i) the date all 2023 PIPE Shares and 2023 Warrant Shares held by or issuable to a 2023
Subscriber may be sold under Rule 144 (“Rule 144”) promulgated under the Securities Act without being subject to
any volume or manner of sale requirements, (ii) the date on which all 2023 PIPE Shares and 2023 Warrant Shares have actually been
sold pursuant to Rule 144 or pursuant to the 2023 PIPE Registration Statement and (iii) the date which is two years from
the date that the initial 2023 PIPE Registration Statement is declared effective (or any Additional Effectiveness Date (as defined in
the 2023 PIPE Subscription Agreements), if applicable). The Company filed the 2023 PIPE Registration Statement and it was declared effective
by the SEC on September 14, 2023.
April 2024 Private Placement
Under the terms of the subscription
agreements entered into with the investors (the “2024 Subscribers”) in the April 2024 Private Placement (the “2024
PIPE Subscription Agreements”), the Company agreed to prepare and file, within 45 days after the closing of the April 2024
Private Placement (the “2024 Filing Deadline”), one or more registration statements (each a “2024 PIPE Registration
Statement”) with the SEC to register for resale the Class A Ordinary Shares (the “2024 PIPE Shares”) issued under
the 2024 PIPE Subscription Agreements and the Class A Ordinary Shares issuable upon exercise of the pre-funded warrants (the “2024
Pre-Funded Warrants” and, together with the 2023 Pre-Funded Warrants, the “Pre-Funded Warrants”) issued to purchase
up to 18,732,301 Class A Ordinary Shares (the “2024 Warrant Shares”) issued pursuant to the 2024 PIPE Subscription Agreements,
and to cause the applicable 2024 PIPE Registration Statement(s) to become effective within a specified period after the 2024 Filing
Deadline. The Company also agreed to use its best efforts to keep such 2024 PIPE Registration Statement effective until the earlier of
(i) the date all 2024 PIPE Shares and 2024 Warrant Shares held by or issuable to a 2024 Subscriber may be sold under Rule 144
(“Rule 144”) promulgated under the Securities Act without being subject to any volume or manner of sale requirements,
(ii) the date on which all 2024 PIPE Shares and 2024 Warrant Shares have actually been sold pursuant to Rule 144 or pursuant
to the 2024 PIPE Registration Statement and (iii) the date which is two years from the date that the initial 2024 PIPE Registration
Statement is declared effective (or any Additional Effectiveness Date (as defined in the 2024 PIPE Subscription Agreements), if applicable).
The Company filed the 2024 PIPE Registration Statement on May 24, 2024, which was subsequently declared effective by the SEC on
June 3, 2024.
Dividends
We have not paid any cash
dividends on our shares to date and do not expect to pay cash dividends in the foreseeable future. The payment of cash dividends in the
future will be dependent upon our ability to comply with relevant legal requirements as well as our revenues and earnings, if any, capital
requirements and general financial condition. The payment of any dividends will be within the discretion of the Zura Board. It is the
present intention of our Board of Directors to retain all earnings, if any, for use in our business operations and, accordingly, our
board does not anticipate declaring any dividends in the foreseeable future.
Our Transfer Agent
The transfer agent for our
Class A ordinary shares is Continental Stock Transfer & Trust Company, 17 Battery Place, New York, New York 10004. We have
agreed to indemnify Continental Stock Transfer & Trust Company in its roles as transfer agent, its agents and each of its shareholders,
directors, officers and employees against all claims and losses that may arise out of acts performed or omitted for its activities in
that capacity, except for any liability due to any gross negligence, willful misconduct or bad faith of the indemnified person or entity.
Listing of Our Securities
Our Class A Ordinary
Shares are listed on Nasdaq under the symbol “ZURA”.
Extraordinary General Meetings of Shareholders
Our MAA provide that the
directors, the chief executive officer or the chairman of the Board of Directors may call general meetings, and they shall on a shareholders’
requisition forthwith proceed to convene an extraordinary general meeting of the Company. A shareholders’ requisition is a requisition
of shareholders holding at the date of deposit of the requisition not less than 10% cent in par value of the issued shares which as at
that date carry the right to vote at general meetings of the Company.
Advance Notice Requirements for Shareholder
Proposals and Director Nominations
Our MAA provide that shareholders
seeking to bring business before our annual general meeting, or to nominate candidates for election as directors at our annual general
meeting, must provide timely notice of their intent in writing. To be timely, a shareholder’s notice will need to be delivered
to our principal executive offices not less than 120 calendar days before the date of the proxy statement released to shareholders in
connection with the previous year’s annual general meeting or, if we did not hold an annual general meeting in the previous
year, or if the date of the current year’s annual general meeting has been changed by more than 30 days from the date of the
previous year’s annual general meeting, then the deadline shall be set by our Board of Directors with such deadline being
a reasonable time before we begin to print and send the related proxy materials. Our MAA also specify certain requirements as to the
form and content of a shareholders’ meeting. These provisions may preclude our shareholders from bringing matters before our annual
general meeting or from making nominations for directors at our annual general meeting.
Authorized but Unissued Shares
Our authorized but unissued
Zura Class A Ordinary Shares and preference shares are available for future issuances without shareholder approval and could be
utilized for a variety of corporate purposes, including future offerings to raise additional capital, acquisitions and employee benefit
plans. The existence of authorized but unissued and unreserved Zura Class A Ordinary Shares and preference shares could render more
difficult or discourage an attempt to obtain control of us by means of a proxy contest, tender offer, merger or otherwise.
DESCRIPTION
OF DEBT SECURITIES
We may issue debt securities
from time to time, in one or more series, as either senior or subordinated debt or as senior or subordinated convertible debt. While
the terms we have summarized below will apply generally to any debt securities that we may offer under this prospectus, we will describe
the particular terms of any debt securities that we may offer in more detail in the applicable prospectus supplement. The terms of any
debt securities offered under a prospectus supplement may differ from the terms described below.
We will issue the debt securities
under either the senior indenture or the subordinated indenture that we will enter into with trustee named in the applicable indenture.
If we offer senior debt securities, we will issue them under the senior indenture. If we issue subordinated debt securities, we will
issue them under the subordinated indenture. We have filed the forms of indentures as an exhibit to the registration statement of which
this prospectus is a part, and supplemental indentures and forms of debt securities containing the terms of the debt securities being
offered will be filed as exhibits to the registration statement of which this prospectus is a part or will be incorporated by reference
from reports that we file with the SEC. The indentures will be qualified under the Trust Indenture Act of 1939, as amended, or the Trust
Indenture Act. Unless the context requires otherwise, whenever we refer to the indenture, we are referring to the senior indenture or
the subordinated indenture, as applicable, and we also are referring to any supplemental indentures that specify the terms of a particular
series of debt securities.
The following summary of
material provisions of the debt securities and the indentures is subject to, and qualified in its entirety by reference to, all of the
provisions of the indenture applicable to a particular series of debt securities. We urge you to read the applicable prospectus supplements
and any related free writing prospectuses related to the debt securities that we may offer under this prospectus, as well as the complete
indenture that contains the terms of the debt securities.
General
The indenture does not limit
the amount of debt securities that we may issue. It provides that we may issue debt securities up to the principal amount that we may
authorize and may be in any currency or currency unit that we may designate. Except for the limitations on consolidation, merger and
sale of all or substantially all of our assets contained in the indenture, the terms of the indenture do not contain any covenants or
other provisions designed to give holders of any debt securities protection against changes in our operations, financial condition or
transactions involving us.
We may issue the debt securities
issued under the indenture as “discount securities,” which means they may be sold at a discount below their stated principal
amount. These debt securities, as well as other debt securities that are not issued at a discount, may be issued with “original
issue discount,” or OID, for U.S. federal income tax purposes because of interest payment and other characteristics or terms of
the debt securities. Material U.S. federal income tax considerations applicable to debt securities issued with OID will be described
in more detail in any applicable prospectus supplement.
We will describe in the applicable prospectus
supplement the terms of the series of debt securities being offered, including:
| · | the
title of the series of debt securities; |
| · | any
limit upon the aggregate principal amount that may be issued; |
| · | the
maturity date or dates; |
| · | the
form of the debt securities of the series; |
| · | the
applicability of any guarantees; |
| · | whether
or not the debt securities will be secured or unsecured, and the terms of any secured debt; |
| · | whether
the debt securities rank as senior debt, senior subordinated debt, subordinated debt or any
combination thereof, and the terms of any subordination; |
| · | if
the price (expressed as a percentage of the aggregate principal amount thereof) at which
such debt securities will be issued is a price other than the principal amount thereof, the
portion of the principal amount thereof payable upon declaration of acceleration of the maturity
thereof, or if applicable, the portion of the principal amount of such debt securities that
is convertible into another security or the method by which any such portion shall be determined; |
| · | the
interest rate or rates, which may be fixed or variable, or the method for determining the
rate and the date interest will begin to accrue, the dates interest will be payable and the
regular record dates for interest payment dates or the method for determining such dates; |
| · | our
right, if any, to defer payment of interest and the maximum length of any such deferral period; |
| · | if
applicable, the date or dates after which, or the period or periods during which, and the
price or prices at which, we may, at our option, redeem the series of debt securities pursuant
to any optional or provisional redemption provisions and the terms of those redemption provisions; |
| · | the
date or dates, if any, on which, and the price or prices at which we are obligated, pursuant
to any mandatory sinking fund or analogous fund provisions or otherwise, to redeem, or at
the holder’s option to purchase, the series of debt securities and the currency or
currency unit in which the debt securities are payable; |
| · | the
denominations in which we will issue the series of debt securities, if other than denominations
of $1,000 and any integral multiple thereof; |
| · | any
and all terms, if applicable, relating to any auction or remarketing of the debt securities
of that series and any security for our obligations with respect to such debt securities
and any other terms which may be advisable in connection with the marketing of debt securities
of that series; |
| · | whether
the debt securities of the series shall be issued in whole or in part in the form of a global
security or securities; the terms and conditions, if any, upon which such global security
or securities may be exchanged in whole or in part for other individual securities; and the
depositary for such global security or securities; |
| · | if
applicable, the provisions relating to conversion or exchange of any debt securities of the
series and the terms and conditions upon which such debt securities will be so convertible
or exchangeable, including the conversion or exchange price, as applicable, or how it will
be calculated and may be adjusted, any mandatory or optional (at our option or the holders’
option) conversion or exchange features, the applicable conversion or exchange period and
the manner of settlement for any conversion or exchange; |
| · | if
other than the full principal amount thereof, the portion of the principal amount of debt
securities of the series which shall be payable upon declaration of acceleration of the maturity
thereof; |
| · | additions
to or changes in the covenants applicable to the particular debt securities being issued,
including, among others, the consolidation, merger or sale covenant; |
| · | additions
to or changes in the Events of Default with respect to the securities and any change in the
right of the trustee or the holders to declare the principal, premium, if any, and interest,
if any, with respect to such securities to be due and payable; |
| · | additions
to or changes in or deletions of the provisions relating to covenant defeasance and legal
defeasance; |
| · | additions
to or changes in the provisions relating to satisfaction and discharge of the indenture; |
| · | additions
to or changes in the provisions relating to the modification of the indenture both with and
without the consent of holders of debt securities issued under the indenture; |
| · | the
currency of payment of debt securities if other than U.S. dollars and the manner of determining
the equivalent amount in U.S. dollars; |
| · | whether
interest will be payable in cash or additional debt securities at our or the holders’
option and the terms and conditions upon which the election may be made; |
| · | the
terms and conditions, if any, upon which we will pay amounts in addition to the stated interest,
premium, if any and principal amounts of the debt securities of the series to any holder
that is not a “United States person” for federal tax purposes; |
| · | any
restrictions on transfer, sale or assignment of the debt securities of the series; and |
| · | any
other specific terms, preferences, rights or limitations of, or restrictions on, the debt
securities, any other additions or changes in the provisions of the indenture, and any terms
that may be required by us or advisable under applicable laws or regulations. |
Conversion or Exchange Rights
We will set forth in the
applicable prospectus supplement the terms on which a series of debt securities may be convertible into or exchangeable for our Class A
Ordinary Shares or our other securities. We will include provisions as to settlement upon conversion or exchange and whether conversion
or exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of our
Class A Ordinary Shares or our other securities that the holders of the series of debt securities receive would be subject to adjustment.
Consolidation, Merger or Sale
Unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, the indenture will not contain any covenant that restricts
our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of our assets as an entirety or substantially as
an entirety. However, any successor to or acquirer of such assets (other than a subsidiary of ours) must assume all of our obligations
under the indenture or the debt securities, as appropriate.
Events of Default under the Indenture
Unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, the following are events of default under the indenture
with respect to any series of debt securities that we may issue:
| · | if
we fail to pay any installment of interest on any series of debt securities, as and when
the same shall become due and payable, and such default continues for a period of 90 days;
provided, however, that a valid extension of an interest payment period by us in accordance
with the terms of any indenture supplemental thereto shall not constitute a default in the
payment of interest for this purpose; |
| · | if
we fail to pay the principal of, or premium, if any, on any series of debt securities as
and when the same shall become due and payable whether at maturity, upon redemption, by declaration
or otherwise, or in any payment required by any sinking or analogous fund established with
respect to such series; provided, however, that a valid extension of the maturity of such
debt securities in accordance with the terms of any indenture supplemental thereto shall
not constitute a default in the payment of principal or premium, if any; |
| · | if
we fail to observe or perform any other covenant or agreement contained in the debt securities
or the indenture, other than a covenant specifically relating to another series of debt securities,
and our failure continues for 90 days after we receive written notice of such failure,
requiring the same to be remedied and stating that such is a notice of default thereunder,
from the trustee or holders of at least 25% in aggregate principal amount of the outstanding
debt securities of the applicable series; and |
| · | if
specified events of bankruptcy, insolvency or reorganization occur. |
If an event of default with
respect to debt securities of any series occurs and is continuing, other than an event of default specified in the last bullet point
above, the trustee or the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series, by
notice to us in writing, and to the trustee if notice is given by such holders, may declare the unpaid principal of, premium, if any,
and accrued interest, if any, due and payable immediately. If an event of default specified in the last bullet point above occurs with
respect to us, the principal amount of and accrued interest, if any, of each issue of debt securities then outstanding shall be due and
payable without any notice or other action on the part of the trustee or any holder.
The holders of a majority
in principal amount of the outstanding debt securities of an affected series may waive any default or event of default with respect to
the series and its consequences, except defaults or events of default regarding payment of principal, premium, if any, or interest, unless
we have cured the default or event of default in accordance with the indenture. Any waiver shall cure the default or event of default.
Subject to the terms of the
indenture, if an event of default under an indenture shall occur and be continuing, the trustee will be under no obligation to exercise
any of its rights or powers under such indenture at the request or direction of any of the holders of the applicable series of debt securities,
unless such holders have offered the trustee reasonable indemnity. The holders of a majority in principal amount of the outstanding debt
securities of any series will have the right to direct the time, method and place of conducting any proceeding for any remedy available
to the trustee, or exercising any trust or power conferred on the trustee, with respect to the debt securities of that series, provided
that:
| · | the
direction so given by the holder is not in conflict with any law or the applicable indenture;
and |
| · | subject
to its duties under the Trust Indenture Act, the trustee need not take any action that might
involve it in personal liability or might be unduly prejudicial to the holders not involved
in the proceeding. |
A holder of the debt securities
of any series will have the right to institute a proceeding under the indenture or to appoint a receiver or trustee, or to seek other
remedies only if:
| · | the
holder has given written notice to the trustee of a continuing event of default with respect
to that series; |
| · | the
holders of at least 25% in aggregate principal amount of the outstanding debt securities
of that series have made written request, |
| · | such
holders have offered to the trustee indemnity satisfactory to it against the costs, expenses
and liabilities to be incurred by the trustee in compliance with the request; and |
| · | the
trustee does not institute the proceeding, and does not receive from the holders of a majority
in aggregate principal amount of the outstanding debt securities of that series other conflicting
directions within 90 days after the notice, request and offer. |
These limitations do not
apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest
on, the debt securities.
We will periodically file statements with the
trustee regarding our compliance with specified covenants in the indenture.
Modification of Indenture; Waiver
We and the trustee may change an indenture without
the consent of any holders with respect to specific matters:
| · | to
cure any ambiguity, defect or inconsistency in the indenture or in the debt securities of
any series; |
| · | to
comply with the provisions described above under “Description of Debt Securities—Consolidation,
Merger or Sale;” |
| · | to
provide for uncertificated debt securities in addition to or in place of certificated debt
securities; |
| · | to
add to our covenants, restrictions, conditions or provisions such new covenants, restrictions,
conditions or provisions for the benefit of the holders of all or any series of debt securities,
to make the occurrence, or the occurrence and the continuance, of a default in any such additional
covenants, restrictions, conditions or provisions an event of default or to surrender any
right or power conferred upon us in the indenture; |
| · | to
add to, delete from or revise the conditions, limitations, and restrictions on the authorized
amount, terms, or purposes of issue, authentication and delivery of debt securities, as set
forth in the indenture; |
| · | to
make any change that does not adversely affect the interests of any holder of debt securities
of any series in any material respect; |
| · | to
provide for the issuance of and establish the form and terms and conditions of the debt securities
of any series as provided above under “Description of Debt Securities—General”
to establish the form of any certifications required to be furnished pursuant to the terms
of the indenture or any series of debt securities, or to add to the rights of the holders
of any series of debt securities; |
| · | to
evidence and provide for the acceptance of appointment under any indenture by a successor
trustee; or |
| · | to
comply with any requirements of the SEC in connection with the qualification of any indenture
under the Trust Indenture Act. |
In addition, under the indenture,
the rights of holders of a series of debt securities may be changed by us and the trustee with the written consent of the holders of
at least a majority in aggregate principal amount of the outstanding debt securities of each series that is affected. However, unless
we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, we and the trustee may make the
following changes only with the consent of each holder of any outstanding debt securities affected:
| · | extending
the fixed maturity of any debt securities of any series; |
| · | reducing
the principal amount, reducing the rate of or extending the time of payment of interest,
or reducing any premium payable upon the redemption of any series of any debt securities;
or |
| · | reducing
the percentage of debt securities, the holders of which are required to consent to any amendment,
supplement, modification or waiver. |
Discharge
Each indenture provides that
we can elect to be discharged from our obligations with respect to one or more series of debt securities, except for specified obligations,
including obligations to:
| · | register
the transfer or exchange of debt securities of the series; |
| · | replace
stolen, lost or mutilated debt securities of the series; |
| · | pay
principal of and premium and interest on any debt securities of the series; |
| · | maintain
paying agencies; |
| · | hold
monies for payment in trust; |
| · | recover
excess money held by the trustee; |
| · | compensate
and indemnify the trustee; and |
| · | appoint
any successor trustee. |
In order to exercise our
rights to be discharged, we must deposit with the trustee money or government obligations sufficient to pay all the principal of, any
premium, if any, and interest on, the debt securities of the series on the dates payments are due.
Form, Exchange and Transfer
We will issue the debt securities
of each series only in fully registered form without coupons and, unless we provide otherwise in the applicable prospectus supplement,
in denominations of $1,000 and any integral multiple thereof. The indenture provides that we may issue debt securities of a series in
temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust Company,
or DTC, or another depositary named by us and identified in the applicable prospectus supplement with respect to that series. To the
extent the debt securities of a series are issued in global form and as book-entry, a description of terms relating to any book-entry
securities will be set forth in the applicable prospectus supplement.
At the option of the holder,
subject to the terms of the indenture and the limitations applicable to global securities described in the applicable prospectus supplement,
the holder of the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any
authorized denomination and of like tenor and aggregate principal amount.
Subject to the terms of the
indenture and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt
securities may present the debt securities for exchange or for registration of transfer, duly endorsed or with the form of transfer endorsed
thereon duly executed if so required by us or the security registrar, at the office of the security registrar or at the office of any
transfer agent designated by us for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer
or exchange, we will impose no service charge for any registration of transfer or exchange, but we may require payment of any taxes or
other governmental charges.
We will name in the applicable
prospectus supplement the security registrar, and any transfer agent in addition to the security registrar, that we initially designate
for any debt securities. We may at any time designate additional transfer agents or rescind the designation of any transfer agent or
approve a change in the office through which any transfer agent acts, except that we will be required to maintain a transfer agent in
each place of payment for the debt securities of each series.
If we elect to redeem the debt securities of any
series, we will not be required to:
| · | issue,
register the transfer of, or exchange any debt securities of that series during a period
beginning at the opening of business 15 days before the day of mailing of a notice of
redemption of any debt securities that may be selected for redemption and ending at the close
of business on the day of the mailing; or |
| · | register
the transfer of or exchange any debt securities so selected for redemption, in whole or in
part, except the unredeemed portion of any debt securities we are redeeming in part. |
Information Concerning the Trustee
The trustee, other than during
the occurrence and continuance of an event of default under an indenture, undertakes to perform only those duties as are specifically
set forth in the applicable indenture. Upon an event of default under an indenture, the trustee must use the same degree of care as a
prudent person would exercise or use in the conduct of his or her own affairs. Subject to this provision, the trustee is under no obligation
to exercise any of the powers given it by the indenture at the request of any holder of debt securities unless it is offered reasonable
security and indemnity against the costs, expenses and liabilities that it might incur.
Payment and Paying Agents
Unless we otherwise indicate
in the applicable prospectus supplement, we will make payment of the interest on any debt securities on any interest payment date to
the person in whose name the debt securities, or one or more predecessor securities, are registered at the close of business on the regular
record date for the interest.
We will pay principal of
and any premium and interest on the debt securities of a particular series at the office of the paying agents designated by us, except
that unless we otherwise indicate in the applicable prospectus supplement, we will make interest payments by check that we will mail
to the holder or by wire transfer to certain holders. Unless we otherwise indicate in the applicable prospectus supplement, we will designate
the corporate trust office of the trustee as our sole paying agent for payments with respect to debt securities of each series. We will
name in the applicable prospectus supplement any other paying agents that we initially designate for the debt securities of a particular
series. We will maintain a paying agent in each place of payment for the debt securities of a particular series.
All money we pay to a paying
agent or the trustee for the payment of the principal of or any premium or interest on any debt securities that remains unclaimed at
the end of two years after such principal, premium or interest has become due and payable will be repaid to us, and the holder of the
debt security thereafter may look only to us for payment thereof.
Governing Law
The indenture and the debt
securities will be governed by and construed in accordance with the internal laws of the State of New York, except to the extent that
the Trust Indenture Act of 1939 is applicable.
Provisions Relating only to the Subordinated
Debt Securities
The subordinated debt securities
will be subordinate and junior in priority of payment to certain of our other indebtedness to the extent described in a prospectus supplement.
The indentures in the forms initially filed as exhibits to the registration statement of which this prospectus is a part do not limit
the amount of indebtedness which we may incur, including senior indebtedness or subordinated indebtedness, and do not limit us from issuing
any other debt, including secured debt or unsecured debt.
DESCRIPTION
OF WARRANTS
The following description,
together with the additional information we may include in any applicable prospectus supplement and free writing prospectus, summarizes
the material terms and provisions of the warrants that we may offer under this prospectus, which may consist of warrants to purchase
Class A Ordinary Shares, preferred shares or debt securities and may be issued in one or more series. Warrants may be offered independently
or in combination with Class A Ordinary Shares, preferred shares or debt securities offered by any prospectus supplement. While
the terms we have summarized below will apply generally to any warrants that we may offer under this prospectus, we will describe the
particular terms of any series of warrants in more detail in the applicable prospectus supplement. The following description of warrants
will apply to the warrants offered by this prospectus unless we provide otherwise in the applicable prospectus supplement. The applicable
prospectus supplement for a particular series of warrants may specify different or additional terms.
We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from reports that we file with the
SEC, the form of warrant and/or the warrant agreement and warrant certificate, as applicable, that contain the terms of the particular
series of warrants we are offering, and any supplemental agreements, before the issuance of such warrants. The following summaries of
material terms and provisions of the warrants are subject to, and qualified in their entirety by reference to, all the provisions of
the form of warrant and/or the warrant agreement and warrant certificate, as applicable, and any supplemental agreements applicable to
a particular series of warrants that we may offer under this prospectus. We urge you to read the applicable prospectus supplement related
to the particular series of warrants that we may offer under this prospectus, as well as any related free writing prospectus, and the
complete form of warrant and/or the warrant agreement and warrant certificate, as applicable, and any supplemental agreements, that contain
the terms of the warrants.
General
We will describe in the
applicable prospectus supplement the terms of the series of warrants being offered, including:
| · | the
title of such securities; |
| · | the
offering price and aggregate number of warrants offered; |
| · | the
currency for which the warrants may be purchased; |
| · | if
applicable, the designation and terms of the securities with which the warrants are issued
and the number of warrants issued with each such security or each principal amount of such
security; |
| · | if
applicable, the date on and after which the warrants and the related securities will be separately
transferable; |
| · | if
applicable, the minimum or maximum amount of such warrants which may be exercised at any
one time; |
| · | in
the case of warrants to purchase debt securities, the principal amount of debt securities
purchasable upon exercise of one warrant and the price at, and currency in which, this principal
amount of debt securities may be purchased upon such exercise; |
| · | in
the case of warrants to purchase Class A Ordinary Shares or preferred shares, the number
of Class A Ordinary Shares or preferred shares, as the case may be, purchasable upon
the exercise of one warrant and the price at which these shares may be purchased upon such
exercise; |
| · | the
effect of any merger, consolidation, sale or other disposition of our business on the warrant
agreements and the warrants; |
| · | the
terms of any rights to redeem or call the warrants; |
| · | the
terms of any rights to force the exercise of the warrants; |
| · | any
provisions for changes to or adjustments in the exercise price or number of securities issuable
upon exercise of the warrants; |
| · | the
dates on which the right to exercise the warrants will commence and expire; |
| · | the
manner in which the warrant agreements and warrants may be modified; |
| · | a
discussion of any material or special U.S. federal income tax considerations of holding or
exercising the warrants; |
| · | the
terms of the securities issuable upon exercise of the warrants; and |
| · | any
other specific terms, preferences, rights or limitations of or restrictions on the warrants. |
Before exercising their
warrants, holders of warrants will not have any of the rights of holders of the securities purchasable upon such exercise, including:
| · | in
the case of warrants to purchase debt securities, the right to receive payments of principal
of, or premium, if any, or interest on, the debt securities purchasable upon exercise or
to enforce covenants in the applicable indenture; or |
| · | in
the case of warrants to purchase Class A Ordinary Shares or preferred shares, the right
to receive dividends, if any, or, payments upon our liquidation, dissolution or winding up
or to exercise voting rights, if any. |
Exercise of Warrants
Each warrant will entitle
the holder to purchase the securities that we specify in the applicable prospectus supplement at the exercise price that we describe
in the applicable prospectus supplement. The warrants may be exercised as set forth in the prospectus supplement relating to the warrants
offered. Unless we otherwise specify in the applicable prospectus supplement, warrants may be exercised at any time up to the close of
business on the expiration date set forth in the prospectus supplement relating to the warrants offered thereby. After the close of business
on the expiration date, unexercised warrants will become void.
Upon receipt of payment
and the warrant or warrant certificate, as applicable, properly completed and duly executed at the corporate trust office of the warrant
agent, if any, or any other office, including ours, indicated in the prospectus supplement, we will, as soon as practicable, issue and
deliver the securities purchasable upon such exercise. If less than all of the warrants (or the warrants represented by such warrant
certificate) are exercised, a new warrant or a new warrant certificate, as applicable, will be issued for the remaining warrants. If
we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities as all or part of the exercise
price for warrants.
Governing Law
Unless we otherwise specify
in the applicable prospectus supplement, the warrants and any warrant agreements will be governed by and construed in accordance with
the laws of the State of New York.
Enforceability of Rights by Holders of Warrants
Each warrant agent, if any,
will act solely as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency or trust
with any holder of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants. A warrant
agent will have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including any
duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may, without
the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right to exercise,
and receive the securities purchasable upon exercise of, its warrants.
DESCRIPTION OF UNITS
We might issue units composed
of one or more debt securities, Class A Ordinary Shares, preference shares and warrants in any combination. Each unit will be issued so
that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights
and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities
included in the unit may not be held or transferred separately, at any time or at any time before a specified date. We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from reports that we file with the
SEC, the form of unit agreement, warrant and any supplemental agreements that describe the terms of the series of units we are offering
before the issuance of the related series of units.
We may choose to evidence each series of units by unit certificates
that we would issue under a separate agreement. If we choose to evidence the units by unit certificates, we will enter into the unit agreements
with a unit agent and will indicate the name and address of the unit agent in the applicable prospectus supplement relating to the particular
series of units.
PLAN
OF DISTRIBUTION
We may sell the securities
covered hereby from time to time pursuant to underwritten public offerings, negotiated transactions, block trades or a combination of
these methods. We may sell the securities to or through underwriters or dealers, through agents, or directly to one or more purchasers.
We may distribute securities from time to time in one or more transactions:
| · | at
a fixed price or prices, which may be changed; |
| · | at
market prices prevailing at the time of sale; |
| · | at
prices related to such prevailing market prices; or |
We
may also sell equity securities covered by this registration statement in an “at the market offering” as defined in Rule 415(a)(4) under
the Securities Act. Such offering may be made into an existing trading market for such securities in transactions at other than a fixed
price, either:
| · | on
or through the facilities of The Nasdaq Capital Market or any other securities exchange or
quotation or trading service on which such securities may be listed, quoted or traded at
the time of sale; and/or |
| · | to
or through a market maker otherwise than on The Nasdaq Capital Market or such other securities
exchanges or quotation or trading services. |
Such at the market offerings,
if any, may be conducted by underwriters acting as principal or agent.
A
prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will describe
the terms of the offering of the securities, including, to the extent applicable:
| · | the
name or names of any underwriters, dealers or agents, if any; |
| · | the
purchase price of the securities and the proceeds we will receive from the sale; |
| · | any
options under which underwriters may purchase additional securities from us; |
| · | any
agency fees or underwriting discounts and other items constituting agents’ or underwriters’
compensation; |
| · | any
public offering price; |
| · | any
discounts or concessions allowed or re-allowed or paid to dealers; and |
| · | any
securities exchange or market on which the securities may be listed. |
Only
underwriters named in the prospectus supplement are underwriters of the securities offered by the prospectus supplement.
If
underwriters are used in the sale, they will acquire the securities for their own account and may resell the securities from time
to time in one or more transactions at a fixed public offering price or at varying prices determined at the time of sale. The obligations
of the underwriters to purchase the securities will be subject to the conditions set forth in the applicable underwriting agreement.
We may offer the securities to the public through underwriting syndicates represented by managing underwriters or by underwriters without
a syndicate. Subject to certain conditions, the underwriters will be obligated to purchase all of the securities offered by the prospectus
supplement. Any public offering price and any discounts or concessions allowed or re-allowed or paid to dealers may change from time
to time. We may use underwriters with whom we have a material relationship. We will describe in the prospectus supplement, naming the
underwriter, the nature of any such relationship.
We
may sell securities directly or through agents we designate from time to time. We will name any agent involved in the offering and sale
of securities, and we will describe any commissions and other compensation we will pay the agent in the prospectus supplement. Unless
the prospectus supplement states otherwise, our agent will act on a best-efforts basis for the period of its appointment.
We
may authorize agents or underwriters to solicit offers by certain types of institutional investors to purchase securities from us at
the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment
and delivery on a specified date in the future. We will describe the conditions to these contracts and the commissions we must pay for
solicitation of these contracts in the prospectus supplement.
We
may provide agents and underwriters with indemnification against civil liabilities related to offerings pursuant to this prospectus,
including liabilities under the Securities Act, or contribution with respect to payments that the agents or underwriters may make
with respect to these liabilities. Agents and underwriters may engage in transactions with, or perform services for, us in the ordinary
course of business.
All
securities we offer, other than our Class A Ordinary Shares and Class C Ordinary Shares, will be new issues of securities,
and all securities we offer, other than our Class A Ordinary Shares, will have no established trading market. Any agents or underwriters
may make a market in these securities, but will not be obligated to do so and may discontinue any market making at any time without notice.
We cannot guarantee the liquidity of the trading markets for any securities.
Any
underwriter may engage in overallotment, stabilizing transactions, short covering transactions and penalty bids in accordance with Regulation
M under the Exchange Act. Overallotment involves sales in excess of the offering size, which create a short position. Stabilizing
transactions permit bids to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short
covering transactions involve purchases of the securities in the open market after the distribution is completed to cover short positions.
Penalty bids permit the underwriters to reclaim a selling concession from a dealer when the securities originally sold by the dealer
are purchased in a stabilizing or covering transaction to cover short positions. Those activities may cause the price of the securities
to be higher than it would otherwise be. If commenced, the underwriters may discontinue any of the activities at any time. These transactions
may be effected on any exchange or over-the-counter market or otherwise.
Any
agents and underwriters who are qualified market makers on The Nasdaq Capital Market may engage in passive market making transactions
in the securities on The Nasdaq Capital Market in accordance with Rule 103 of Regulation M, during the business day prior to the
pricing of the offering, before the commencement of offers or sales of the securities. Passive market makers must comply with applicable
volume and price limitations and must be identified as passive market makers. In general, a passive market maker must display
its bid at a price not in excess of the highest independent bid for such security; if all independent bids are lowered below the passive
market maker’s bid, however, the passive market maker’s bid must then be lowered when certain purchase limits are exceeded.
Passive market making may stabilize the market price of the securities at a level above that which might otherwise prevail in the open
market and, if commenced, may be discontinued at any time.
LEGAL
MATTERS
Certain
matters with respect to U.S. federal and New York State law will be passed upon for us by Cooley LLP, New York, New York. Ogier
(Cayman) LLP, Cayman Islands, will pass upon the validity of the securities offered in this prospectus with respect to the Class A
Ordinary Shares and matters of Cayman Islands law.
EXPERTS
The financial statements
appearing in our Annual
Report on Form 10-K for the year ended December 31, 2023 have been audited by WithumSmith+Brown, PC (“Withum”),
independent registered public accountants, as set forth in their report thereon, included therein, and incorporated herein by reference.
The financial statements are incorporated herein by reference in reliance upon such report given on the authority of said firm as experts
in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
We are subject to the information
reporting requirements of the Exchange Act, and we file reports, proxy statements, and other information with the SEC. These reports,
proxy statements, and other information will be available for review at the SEC’s website at www.sec.gov. We also maintain a website
at www.zurabio.com, at which you may access these materials free of charge as soon as reasonably practicable after they are electronically
filed with, or furnished to, the SEC. The information contained in, or that can be accessed through, our website is not part of this
prospectus.
Our website address is www.zurabio.com.
Through our website, we make available, free of charge, the following documents as soon as reasonably practicable after they are electronically
filed with, or furnished to, the SEC, including our Annual Reports on Form 10-K; our proxy statements for our annual and extraordinary
shareholder meetings; our Quarterly Reports on Form 10-Q; our Current Reports on Form 8-K; Forms 3, 4, and 5 and Schedules
13D with respect to our securities filed on behalf of our directors and our executive officers; and amendments to those documents. The
information contained on, or that may be accessed through, our website is not a part of, and is not incorporated into, this prospectus.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to “incorporate
by reference” information into this prospectus from other documents that we file with the SEC, which means that we can disclose
important information to you by referring you to those documents. The information incorporated by reference is considered to be part
of this prospectus and information we file later with the SEC will automatically update and supersede this information. Any statement
contained in this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for
purposes of this prospectus to the extent that a statement contained in this prospectus or a subsequently filed document incorporated
by reference modifies or replaces that statement. The documents we are incorporating by reference as of their respective dates of filing
are (in each case, other than those documents or the portions of those documents not deemed to be filed, including the portions of these
documents that are furnished under Item 2.02 or Item 7.01 of a Current Report on Form 8-K, including any exhibits included
with such Items):
| · | our
Annual Report on Form 10-K for the year ended December 31, 2023, filed with
the SEC on March 28,
2024; |
| · | our
Quarterly Reports on Form 10-Q for the quarters ended March 31, 2024, filed with
the SEC on May 9,
2024, and amended by Amendment No. 1 to the Quarterly Report on Form 10-Q filed
with the SEC on May 15,
2024, and June 30, 2024, filed with the SEC on August 13,
2024; |
Notwithstanding
the foregoing, information furnished under Items 2.02 and 7.01 of any Current Report on Form 8-K, including the related exhibits
under Item 9.01, is not incorporated by reference in this prospectus or any prospectus supplement.
All
documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than
those documents or the portions of those documents not deemed to be filed, including the portions of these documents that are
furnished under Item 2.02 or Item 7.01 of a Current Report on Form 8-K, including any exhibits included with such Items), prior
to the termination of this offering, including all such documents we may file after the date of the initial registration statement of
which this prospectus forms a part and prior to the effectiveness of the registration statement, but excluding any information furnished
to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus
from the date of the filing of such reports and documents.
You
may obtain any of the documents incorporated by reference in this prospectus from the SEC through the SEC’s website at the
address provided above. You also may request a copy of any document incorporated by reference in this prospectus (excluding any exhibits
to those documents, unless the exhibit is specifically incorporated by reference in this document), at no cost, by writing or telephoning
us at the following address and phone number:
Zura Bio Limited
1489 W. Warm Springs Rd. #110
Henderson, NV 89014
Attn: General Counsel
(702) 825-9872
ZURA BIO LIMITED
$300,000,000
ORDINARY SHARES
PREFERENCE SHARES
DEBT SECURITIES
WARRANTS
UNITS
PROSPECTUS
, 2024
The information in this prospectus supplement is not complete
and may be changed. We may not sell these securities or accept an offer to buy these securities until the registration statement filed
with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and it is not soliciting
offers to buy these securities in any state where such offer or sale is not permitted.
SUBJECT TO COMPLETION, DATED SEPTEMBER 3, 2024
PROSPECTUS
ZURA BIO LIMITED
Up to $125,000,000
Class A
Ordinary Shares
We
have entered into a sales agreement, dated September 3, 2024 (the “Sales Agreement”), with Leerink Partners LLC
(“Leerink Partners”), relating to our Class A ordinary shares, par value $0.0001 per share (“Class A
Ordinary Shares”), offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of the
Sales Agreement, from time to time we may offer and sell our Class A Ordinary Shares having an aggregate gross sales price of
up to $125,000,000 through Leerink Partners, acting as sales agent or principal, pursuant to this prospectus.
Our
public shares are currently listed on the Nasdaq Capital Market (“Nasdaq”) under the symbol “ZURA”. On
August 30, 2024, the last reported sales price of our Class A Ordinary Shares
was $4.13 per share.
Sales of our Class A
Ordinary Shares, if any, under this prospectus supplement may be made in sales deemed to be an “at the market offering” as
defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended (the “Securities Act”). Subject
to terms of the Sales Agreement, Leerink Partners is not required to sell any specific number or dollar amount of securities but will
act as our sales agent using commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed
terms between Leerink Partners and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.
Leerink
Partners will be entitled to a commission of 3.0% of the gross sales price per share sold under the Sales Agreement. In connection with
the sale of our Class A Ordinary Shares on our behalf, Leerink Partners will be deemed to be an “underwriter” within
the meaning of the Securities Act and the compensation of Leerink Partners will be deemed to be underwriting commissions or discounts.
We have also agreed to provide indemnification and contributions to Leerink Partners against certain civil liabilities, including liabilities
under the Securities Act or the Securities Exchange Act of 1934, as amended (the “Exchange Act”). See “Plan of Distribution”
beginning on page S-21 for additional information regarding the compensation to be paid to Leerink Partners.
We are an “emerging
growth company” and a “smaller reporting company” under the federal securities laws and, as such, we have elected to
comply with certain reduced public company reporting requirements for this prospectus supplement and related base prospectus and for
future filings.
Investing
in our Class A Ordinary Shares involves a high degree of risk. You should review carefully the risks and uncertainties described
under the heading “Risk Factors” on page S-9
of this prospectus , and under similar headings in the documents that are incorporated by reference into this prospectus.
Neither the Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus
are truthful or complete. Any representation to the contrary is a criminal offense.
Leerink Partners
The date of this prospectus is ,
2024
TABLE OF CONTENTS
ABOUT
THIS PROSPECTUS
This prospectus supplement
relates to an offering of our Class A Ordinary Shares. Before buying any of the Class A Ordinary Shares that we are offering,
we urge you to carefully read this prospectus, together with the information incorporated by reference as described under the headings
“Where You Can Find More Information” and “Incorporation of Certain Information by Reference” in
this prospectus. These documents contain important information that you should consider when making your investment decision. Unless
otherwise stated, the terms “we,” “us,” “our” and “Zura” refer to Zura Bio Limited, a
Cayman Islands exempted company (formerly known, prior to the Business Combination, as JATT Acquisition Corp), or its affiliates.
This prospectus describes
the terms of this offering of Class A Ordinary Shares and also adds to and updates information contained in the documents incorporated
by reference into this prospectus. To the extent the information contained in this prospectus differs from or conflicts with the information
contained in any document incorporated by reference, the information in this prospectus will control. If any statement in one of these
documents is inconsistent with a statement in another document having a later date—for example, a document incorporated by reference
into this prospectus—the statement in the document having the later date modifies or supersedes the earlier statement.
We have not, and Leerink
Partners has not, authorized anyone to provide you with information different from that which is contained in or incorporated by reference
in this prospectus, any accompanying prospectus and in any free writing prospectus that we may authorize for use in connection with this
offering. We take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may
give to you. No one is making offers to sell or seeking offers to buy these securities in any jurisdiction where the offer or sale is
not permitted. You should assume that the information contained in this prospectus is accurate as of the date on the front cover of this
prospectus only and that any information we have incorporated by reference or included in the prospectus is accurate only as of the date
given in the document incorporated by reference or as of the date of the prospectus, as applicable, regardless of the time of delivery
of this prospectus, any accompanying prospectus, any related free writing prospectus, or any sale of our Class A Ordinary Shares.
Our business, financial condition, results of operations and prospects may have changed since those dates.
We further note that the
representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated
by reference into this prospectus supplement or the accompanying prospectus were made solely for the benefit of the parties to such agreement,
including, in some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation,
warranty or covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly,
such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.
MARKET
AND INDUSTRY DATA
Certain information contained
in this document relates to or is based on studies, publications, surveys and other data obtained from third-party sources and our own
internal estimates and research. While we believe these third-party sources to be reliable as of the date of this prospectus, we have
not independently verified the market and industry data contained in this prospectus or the underlying assumptions relied on therein.
Finally, while we believe our own internal research is reliable, such research has not been verified by any independent source. Notwithstanding
the foregoing, we are liable for the information provided in this prospectus.
TRADEMARKS
This
document contains references to trademarks, trade names and service marks belonging to other entities. Solely for convenience, trademarks,
trade names and service marks referred to in this prospectus may appear without the ®
or TM symbols, but such references are not intended to indicate, in any way, that the applicable
owner or licensor will not assert, to the fullest extent under applicable law, its rights to these trademarks and trade names. We do
not intend our use or display of other companies’ trade names, trademarks or service marks to imply a relationship with, or endorsement
or sponsorship of us by, any other companies.
CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus and the documents incorporated by reference herein and any prospectus supplement delivered with this prospectus contain forward-looking
statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. This includes,
without limitation, statements regarding our financial position, business strategy, our objectives, plans, expectations and assumptions.
In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including
any underlying assumptions, are forward- looking statements. The words “anticipate,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,”
“possible,” “potential,” “predict,” “project,” “should,” “will,”
“would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that
a statement is not forward-looking.
The forward-looking statements
are based on the current expectations of the Company and its management thereof and are inherently subject to uncertainties and changes
in circumstances and their potential effects and speak only as of the date of such statement. There can be no assurance that future developments
will be those that have been anticipated. These forward-looking statements involve a number of risks, uncertainties or other assumptions
that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements.
These risks and uncertainties include, but are not limited to:
| · | our
expectations regarding our product candidates and their related benefits, and our beliefs
regarding competing product candidates and products both in development and approved, may
not be achieved; |
| · | our
vision and strategy may not be successful; |
| · | the
timing of key events and initiation of our studies and release of clinical data may take
longer than anticipated or may not be achieved at all; |
| · | expectations
regarding the potential general acceptability and maintenance of our product candidates by
regulatory authorities, payors, physicians, and patients may not be achieved; |
| · | we
may be unable to attract and retain key personnel; |
| · | expectations
with respect to our future operating expenses, capital requirements and needs for additional
financing may not be achieved; |
| · | we
have not completed any clinical trials, and have no products approved for commercial sale; |
| · | we
have incurred significant losses since inception, and expect to incur significant losses
for the foreseeable future and may not be able to achieve or sustain profitability in the
future; |
| · | we
require substantial additional capital to finance our operations, and if we are unable to
raise such capital when needed or on acceptable terms, we may be forced to delay, reduce,
and/or eliminate one or more of our development programs or future commercialization efforts; |
| · | we
may be unable to renew existing contracts or enter into new contracts; |
| · | we
rely on third-party contract development manufacturing organizations for the manufacture
of clinical materials; |
| · | we
rely on contract research organizations, clinical trial sites, and other third parties to
conduct our preclinical studies and clinical trials; |
| · | we
may be unable to obtain regulatory approval for our product candidates, and there may be
related restrictions or limitations of any approved products; |
| · | we
may be unable to successfully respond to general economic and geopolitical conditions; |
| · | we
may be unable to effectively manage growth; |
| · | we
face competitive pressures from other companies worldwide; |
| · | we
may be unable to adequately protect our intellectual property rights; |
| · | our
expectations regarding the use of proceeds from offerings of our securities under this prospectus;
and |
| · | other
factors set forth in documents filed, or to be filed, with the SEC. |
Additional
discussion of the risks, uncertainties and other factors described above, as well as other risks material to our business, can be found
in the section titled “Risk Factors” contained elsewhere in this prospectus and in any applicable prospectus supplement,
any free writing prospectuses we may authorize for use in connection with a specific offering, and in our most recent Annual Report on
Form 10-K and in our most recent Quarterly Report on Form 10-Q, as well as any amendments thereto reflected in subsequent filings
with the SEC, which are incorporated by reference into this prospectus in their entirety. We may not actually achieve the plans,
intentions or expectations disclosed in our forward-looking statements. New risk factors emerge from time to time and it is not possible
to predict all such risk factors, nor can we assess the impact of all such risk factors on our business or the extent to which any factor
or combination of factors may cause actual results to differ materially from those contained in any forward-looking statements. Our forward-looking
statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures, investments or other
transactions we may execute.
Forward-looking statements
are not guarantees of performance. You should not put undue reliance on our forward-looking statements. Forward-looking statements, reflect
our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this
prospectus, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete,
and statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available
relevant information. All forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their
entirety by the foregoing cautionary statements. We undertake no obligation to update or revise publicly any forward-looking statements,
whether as a result of new information, future events or otherwise, except as required by law.
PROSPECTUS
SUMMARY
This summary highlights
selected information included in this prospectus or incorporated by reference in this prospectus, and does not contain all of the information
that may be important to you in making an investment decision. This summary is qualified in its entirety by the more detailed information
included in this prospectus. Before making your investment decision with respect to our Class A Ordinary Shares, you should carefully
read this entire prospectus, including the information under “Risk Factors” contained in this prospectus and any applicable
prospectus supplement, and under similar headings in the other documents that are incorporated by reference in this prospectus. You should
also carefully read the information incorporated by reference into this prospectus, including our financial statements, and exhibits
to the registration statement of which this prospectus is a part. Unless the context indicates otherwise, references in this prospectus
to “Zura,” “Company,” “we,” “us,” “our” and similar terms prior are intended
to refer to Zura Bio Limited and its consolidated subsidiaries, and references in this prospectus to the “Board of Directors”
or “Zura Board” are intended to refer to the board of directors of Zura Bio Limited.
Overview
Zura Bio Limited, formerly
known as JATT Acquisition Corp, is a multi-asset clinical-stage biotechnology company focused on developing novel medicines for immune
and inflammatory disorders. With its experienced leadership team, Zura aims to become a leader in the autoimmune and inflammatory field.
We are currently developing
three clinical-stage product candidates to address indications with high unmet needs and significant commercial opportunity.
| · | Tibulizumab
(ZB-106) is an IgG-scFv bispecific dual-antagonist antibody engineered by the fusion of elements
of TALTZ® (ixekizumab) and tabalumab that neutralizes IL-17A and BAFF. These cytokines
play pivotal roles in various inflammatory and autoimmune disorders. By targeting IL-17A
and BAFF, tibulizumab demonstrates potential in mitigating chronic inflammation while preserving
immune system integrity. Three Phase 1/1b clinical studies have been completed with tibulizumab
to date, including in participants with rheumatoid arthritis and Sjögren’s syndrome. |
| · | Crebankitug
(ZB-168) is a fully human, high affinity monoclonal antibody that binds and neutralizes the
IL-7 receptor chain (IL-7R) alpha. IL-7Rα sits at the nexus of two key immune pathways, IL-7
and thymic stromal lymphopoietin (TSLP), thus IL-7Rα has the potential to block activation
through either of these pathways. As a result, we believe crebankitug could be therapeutically
relevant in a broad set of indications where the IL-7 or TSLP pathways may be involved. Three
Phase 1/1b clinical studies have been conducted to date. There are additional IL-7Rα
inhibitors under development for conditions like alopecia areata, atopic dermatitis, and
ulcerative colitis. We are actively assessing the competitive landscape and evaluating potential
therapeutic indications to guide our future development efforts for crebankitug. |
| · | Torudokimab
(ZB-880) is a fully human, high affinity monoclonal antibody that neutralizes IL-33, preventing
ST2-dependent and ST2-independent (e.g., RAGE) inflammation. The IL-33/ST2 axis stands as
a validated therapeutic target for conditions such as chronic obstructive pulmonary disease
(COPD) and asthma. Three Phase 1/2 clinical studies have been conducted to date. We are actively
assessing the competitive landscape and evaluating potential therapeutic indications to guide
our future development efforts for torudokimab. |
The Business Combination
We were originally known
as JATT Acquisition Corp. On March 20, 2023 (the “Closing Date”), Zura Bio Limited, a limited company incorporated under
the laws of England and Wales (“Legacy Zura”), JATT Acquisition Corp, a Cayman Islands exempted company (“JATT”),
JATT Merger Sub, a Cayman Islands exempted company and wholly owned subsidiary of JATT (“Merger Sub”), JATT Merger Sub 2,
a Cayman Islands exempted company and wholly owned subsidiary of JATT (“Merger Sub 2”) and Zura Bio Holdings Ltd, a Cayman
Islands exempted company (“Holdco”), consummated the closing of the transactions contemplated by the Business Combination
Agreement dated June 16, 2022, as amended on September 20, 2022, November 14, 2022 and January 13, 2023, by and among
Legacy Zura, JATT, Merger Sub, Merger Sub 2 and Holdco (the “Business Combination Agreement”), following the approval at
an extraordinary general meeting of JATT’s shareholders held on March 16, 2023 (the “Extraordinary General Meeting”
and the consummation of such transactions, the “Closing”).
The
Business Combination generated approximately $56.7 million in net proceeds. On March 21, 2023, the Company’s Class A
Ordinary Shares began trading on the Nasdaq under the under the symbol “ZURA”.
Stock Exchange Listing
Zura’s
Class A Ordinary Shares are currently listed on Nasdaq under the symbol “ZURA”.
Corporate Information
Our
principal executive offices are located at Zura’s principal executive offices are located at 1489 W. Warm Springs Road,
#110, Henderson, Nevada and our telephone number is (702) 825-9872. Our corporate website address is www.zurabio.com. Information
contained on or accessible through our website is not a part of this prospectus, and the inclusion of our website address in this prospectus
is an inactive textual reference only.
Emerging Growth Company
We are an “emerging
growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our Business Startups
Act of 2012 (the “JOBS Act”), and we may take advantage of certain exemptions from various reporting requirements that are
applicable to other public companies that are not emerging growth companies, including, but not limited to, not being required to comply
with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley
Act”), reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements, and exemptions
from the requirements of holding a nonbinding advisory vote on executive compensation and shareholder approval of any golden parachute
payments not previously approved.
Further, Section 102(b)(1) of
the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting standards until
private companies (that is, those that have not had a Securities Act registration statement declared effective or do not have a class
of securities registered under the Exchange Act) are required to comply with the new or revised financial accounting standards. The JOBS
Act provides that a company can elect to opt out of the extended transition period and comply with the requirements that apply to non-emerging
growth companies but any such election to opt out is irrevocable.
We will remain as an emerging
growth company until the earlier of: (i) the last day of the fiscal year (a) following the fifth anniversary of the closing
of JATT’s IPO, (b) in which we have total annual gross revenue of at least $1.235 billion, or (c) in which we are deemed
to be a large accelerated filer, which means the market value of our common equity that is held by non-affiliates exceeds $700 million
as of the last business day of its most recently completed second fiscal quarter; and (ii) the date on which we have issued more
than $1.235 billion in non-convertible debt securities during the prior three-year period. References herein to “emerging growth
company” have the meaning associated with it in the JOBS Act.
Smaller Reporting Company
Additionally, we are currently
a “smaller reporting company” as defined in Item 10(f)(1) of Regulation S-K. Smaller reporting companies may take
advantage of certain reduced disclosure obligations, including, among other things, providing only two years of audited financial
statements. We may continue to be a smaller reporting company if either (i) the market value of our stock held by non-affiliates
is less than $250 million or (ii) our annual revenue is less than $100 million during the most recently completed fiscal year
and the market value of our stock held by non-affiliates is less than $700 million.
THE
OFFERING
Class A
Ordinary Shares offered by us |
Our
Class A Ordinary Shares having an aggregate offering price of up to $125,000,000. |
|
|
Class A Ordinary Shares
to be outstanding after the offering |
Up
to 94,701,175 Class A Ordinary Shares, assuming sales of 31,017,369 Class A Ordinary Shares in this offering at an assumed
offering price of $4.03 per share, which was the last reported sale price of our Class A Ordinary Shares on Nasdaq on August
26, 2024. The actual number of shares issued will vary depending on the sales prices at which our Class A Ordinary Shares are
sold under this offering. |
|
|
Plan of Distribution |
“At
the market offering” that may be made from time to time through our sales agent, Leerink Partners. See “Plan of Distribution”
on page S-21 of this prospectus supplement. |
|
|
Use of Proceeds |
We
intend to use the net proceeds from this offering as working capital, including continuing to advance our pipeline through preclinical
studies, clinical trials, regulatory submissions, commercial planning and commercialization, and for general corporate purposes.
See “Use of Proceeds” on page S-12 of this prospectus supplement. |
|
|
Risk Factors |
Investing
in our Class A Ordinary Shares involves a high degree of risk. See the information contained in or incorporated by reference
under the heading “Risk Factors” on page S-9 of this prospectus supplement, in the accompanying prospectus
and in the documents incorporated by reference into this prospectus supplement and any free writing prospectus that we authorize
for use in connection with this offering. |
|
|
Nasdaq Capital Market symbol |
“ZURA” |
The
number of Class A Ordinary Shares that will be outstanding after this offering is based on 63,683,806 Class A Ordinary
Shares outstanding as of June 30, 2024 and excludes as of June 30, 2024:
| · | options
to purchase an aggregate of 10,782,788 Class A Ordinary Shares issued to certain of
our directors, executives and employees, with a weighted average exercise price of $2.86
per share; |
| · | 1,442,473
Class A Ordinary Shares underlying restricted stock units issued to certain of our officers,
directors, employees, with a weighted average grant date fair value of $5.95 per share; |
| · | 2,000,000
Class A Ordinary Shares issuable upon exercise of Z33 Series Seed Preferred Shares
Put Right; |
| · | 3,179,417
Class A Ordinary Shares reserved for future equity award grants under the 2023 Equity
Incentive Plan and 2023 Employee Stock Purchase Plan; |
| · | the
exchange of 6,703,428 public warrants and 4,080,580 private placement warrants on August 8,
2024, pursuant to our exchange offer and consent solicitation, and the mandatory exchange
of the remaining 196,568 public warrants and 1,829,420 private placement warrants on August 27,
2024; |
| · | 3,782,000
Class A Ordinary Shares issuable upon the exercise of the 2023 Pre-Funded Warrants and
16,102,348 Class A Ordinary Shares issuable upon the exercise of the 2024 Pre-Funded
Warrants, each with a weighted average exercise price of $0.001 per share; and |
| · | the
issuance of 4,000,000 pre-funded warrants (the “Exchange Warrants”) to purchase
4,000,000 Class A Ordinary Shares to entitles affiliated with Venrock Healthcare Capital
Partners on August 21, 2024 in connection with the surrender and cancellation of 4,000,000
Class A Ordinary Shares, with a weighted average exercise price of $0.001 per share. |
To the extent additional
shares have been or will be issued, including under the above securities, prices lower than the price of our Class A Ordinary Shares
in this offering, you will incur further dilution.
RISK
FACTORS
Investing in our securities
involves risks. Before making an investment decision, you should carefully consider the risks and other information we include or incorporate
by reference in this prospectus , and in any prospectus supplement or free writing prospectus that we have authorized for use in connection
with this offering. In particular, you should consider the risk factors described under the heading “Risk Factors” in our
most recent Annual Report on Form 10-K, as may be revised or supplemented by our subsequent Quarterly Reports on Form 10-Q
or Current Reports on Form 8-K, each of which are on file with the SEC and are incorporated herein by reference, and which may be
amended, supplemented or superseded from time to time by other reports we file with the SEC in the future. In addition to those risk
factors, there may be additional risks and uncertainties which are not currently known to us or that we currently deem immaterial. Our
business, financial condition or results of operations could be materially adversely affected by any of these risks. The occurrence of
any of these risks might cause you to lose all or part of your investment in the offered securities.
Risks Related to This Offering
If you purchase Class A Ordinary Shares
in this offering, you will suffer immediate and substantial dilution in the book value per Class A Ordinary Share purchased in the
offering.
The
Class A Ordinary Shares sold in this offering from time to time will be sold at various
prices; however, we expect that the per Class A Ordinary Share offering price will be
substantially higher than the as adjusted net tangible book value per Class A Common
Share. Therefore, assuming that an aggregate of 31,017,369 Class A Ordinary Shares are
sold at a price of $4.03 per share, which was the closing price of our Class A Ordinary
Shares on Nasdaq on August 26, 2024, for aggregate gross proceeds of approximately $125,000,000,
and after deducting commissions and estimated offering expenses payable by us, new investors
in this offering will incur immediate dilution of $2.93 per share. See “Dilution”
on page S-13 of this prospectus for a more detailed discussion of the dilution you
will incur in connection with this offering.
You may experience future dilution as a
result of future equity issuances.
In order to raise additional
capital, we may at any time, including during the pendency of this offering, offer additional Class A Ordinary Shares or other securities
convertible into or exchangeable for our Class A Ordinary Shares at prices that may not be the same as the price per share in this
offering. We may sell shares or other securities in any other offering at a price per share that is less than the price per share paid
by investors in this offering, and investors purchasing shares or other securities in the future could have rights superior to existing
shareholders. The price per share at which we sell additional Class A Ordinary Shares, or securities convertible or exchangeable
into Class A Ordinary Shares, in future transactions may be higher or lower than the price per share paid by investors in this offering.
In addition, as of June 30, 2024, there were (i) options to purchase an aggregate of 10,782,788 Class A Ordinary Shares
issued to certain of our directors, executives and employees, with a weighted average exercise price of $2.86 per share; (ii) 1,442,473
Class A Ordinary Shares underlying restricted stock units issued to certain of our officers, directors, employees, with a weighted
average grant date fair value of $5.95 per share; (iii) 2,000,000 Class A Ordinary Shares issuable upon exercise of Z33 Series Seed
Preferred Shares Put Right; (iv) 3,179,417 Class A Ordinary Shares reserved for future equity award grants under the 2023 Equity
Incentive Plan and 2023 Employee Stock Purchase Plan; (v) the exchange of 6,703,428 public
warrants and 4,080,580 private placement warrants on August 8, 2024, pursuant to our exchange offer and consent solicitation, and
the mandatory exchange of the remaining 196,568 public warrants and 1,829,420 private placement warrants on August 27, 2024; (vi) 3,782,000
Class A Ordinary Shares issuable upon the exercise of the 2023 Pre-Funded Warrants and 16,102,348 Class A Ordinary Shares issuable
upon the exercise of the 2024 Pre-Funded Warrants, each with a weighted average exercise price of $0.001 per share; and (vii) the
issuance of the Exchange Warrants to purchase 4,000,000 Class A Ordinary Shares, with a weighted average exercise price of $0.001 per
share.
To
the extent additional shares have been or will be issued, including under the above securities, prices lower than the price of our Class A
Ordinary Shares in this offering, you will incur further dilution.
Sales of a significant number of Class A
Ordinary Shares, or any other securities, in the public markets, or the perception that such sales could occur, could depress the market
price of our Class A Ordinary Shares.
Sales
of a substantial number of Class A Ordinary Shares, or any other securities, in the public markets, or the perception that such
sales could occur, could depress the market price of our Class A Ordinary Shares and impair our ability to raise capital
through the sale of additional equity securities. We may sell a significant number of Class A Ordinary Shares at any time pursuant
to this prospectus or in one or more separate offerings.
We may also offer and
sell up to $300,000,000 in the aggregate of our Class A Ordinary Shares, preferred shares, debt securities, warrants and/or units,
pursuant to our shelf registration statement on Form S-3, for which this prospectus forms a part. Additionally, the market
price of our Class A Ordinary Shares or other securities could decline if holders of our shares sell them, including pursuant
to the resale registration statements, or are perceived by the market as intending to sell them.
Pursuant to the registration
rights we have with certain holders of our securities, we filed a resale shelf registration statement covering the resale of up to an
aggregate of 30,251,124 Class A Ordinary Shares and 3,782,000 Class A Ordinary Shares issuable upon the exercise of the 2023
Pre-Funded Warrants, which was declared effective on September 14, 2023. We filed a registration statement to register the resale
of 41,596,750 Class A Ordinary Shares issuable upon the exercise of the 2024 Pre-Funded Warrants, which registration statement was
declared effective on June 3, 2024.
We cannot predict the effect
that future sales of our Class A Ordinary Shares or any other securities would have on the market price of our Class A Ordinary
Shares.
The actual number of shares we may sell
under the Sales Agreement, at any one time or in total, as well as the gross proceeds resulting from those sales, is uncertain.
Subject
to certain limitations in the Sales Agreement and compliance with applicable law, we have the discretion to deliver a placement notice
to Leerink Partners at any time throughout the term of the Sales Agreement. The number of shares that may be sold by Leerink Partners
under the Sales Agreement and upon delivery of a placement notice will fluctuate based on the market price of our Class A Ordinary
Shares during the sales period and any limits we set with Leerink Partners. Because the price of any share sold will fluctuate based
on the market price of our Class A Ordinary Shares during the sales period, it is not possible to predict the number of shares that
may ultimately be sold or the gross proceeds that may be raised in connection with the sale of Class A Ordinary Shares offered
under this prospectus.
We have broad discretion in the use of
our cash and cash equivalents, including any net proceeds we receive in this offering, and may not use them effectively.
Our
management has broad discretion to use our cash and cash equivalents, including any net proceeds we receive in this offering, to fund
our operations and could spend these funds in ways that do not improve our results of operations or enhance the value of our Class A
Ordinary Shares, and you will not have the opportunity as part of your investment decision to assess whether the net proceeds are being
used effectively. The failure by our management to apply these funds effectively could result in financial losses that could have a material
adverse effect on our business, cause the price of our Class A Ordinary Shares to decline and delay the development of our product
candidates. You will not have the opportunity to influence our decisions on how to use our cash and cash equivalents, including
any net proceeds from this offering. Pending their use to fund our operations, we may invest our cash and cash equivalents, including
any net proceeds from this offering, in a manner that does not produce income or that loses value.
Any Class A Ordinary Shares offered
hereby will be sold in “at the market offerings” and investors who buy shares at different times will likely pay different
prices.
Investors who purchase shares
in this offering at different times will likely pay different prices, and accordingly may experience different levels of dilution and
different outcomes in their investment results. We will have discretion, subject to market demand, to vary the timing, pricing and number
of shares sold, and there is no maximum sales price. Pursuant to any parameters we may set, we expect to have a minimum sales price for
Class A Ordinary Shares sold in this offering, which will limit our ability to make sales if the public trading price of our Class A
Ordinary Shares drops below that minimum sales price. Such minimum sales price may be below the price paid by investors in this offering.
Further, we may increase or decrease such minimum sales price in the future. Investors may experience a decline in the value of the shares
they purchase in this offering as a result of sales made at prices lower than the prices they paid.
We believe that we were a passive foreign
investment company (“PFIC”) for U.S. federal income tax purposes for the taxable year ended December 31, 2023, and we may
be a PFIC in the current or future taxable years, which could result in adverse U.S. federal income tax consequences to U.S. investors.
If the Company is treated
as a PFIC, within the meaning of Section 1297 of the Internal Revenue Code of 1986, as amended (the “Code”) for any
taxable year (or portion thereof) during which a U.S. Holder (as defined in “Material U.S. Federal Income Tax Consequences to U.S.
Holders”) holds Class A Ordinary Shares or warrants (regardless of whether the Company remains a PFIC for subsequent taxable
years), certain adverse U.S. federal income tax consequences, such as taxation at the highest marginal ordinary income tax rates on capital
gains and on certain actual or deemed distributions, and interest charges on certain taxes treated as deferred, may apply to such U.S.
Holder and such U.S. Holder might be subject to additional reporting requirements. Under certain circumstances, certain elections may
be available to U.S. Holders of Class A Ordinary Shares to mitigate some of the adverse tax consequences resulting from PFIC treatment.
We
believe that we were a PFIC for our most recently completed taxable year, and based on the nature of our business, the projected composition
of our gross income and the projected composition and estimated fair market values of our assets, we may be a PFIC for our current taxable
year and any subsequent tax years. Because the Company’s PFIC status for the current taxable year or any subsequent taxable year
will not be determinable until after the end of each such taxable year, the Company cannot assure you that it will not be a PFIC in the
current taxable year or in any subsequent taxable year. If the Company were determined to be a PFIC, you may be unable to make certain
advantageous elections with respect to your ownership of the Class A ordinary shares that could mitigate some of the adverse consequences
of the Company’s PFIC status, or making such elections retroactively could have adverse tax consequences to you. The Company is
not representing to you, and there can be no assurance, that the Company will or will not be treated as a PFIC for this taxable year
or in any subsequent taxable year. The Company has not sought and will not seek any rulings from the IRS or any opinion from any tax
advisor as to such tax treatment. If we determine that we are a PFIC for any taxable year, upon written request by a U.S. Holder, we
will endeavor to provide or make available to such U.S. Holder such information as the IRS may require to enable the U.S. Holder to make
to make and maintain a “qualified electing fund” election, but there can be no assurance that we will timely provide such
required information, and such election in any event may be unavailable with respect to an owner of our warrants. U.S. Holders should
consult with, and rely solely upon, their tax advisors to determine the application of the PFIC rules to them and any resultant
tax consequences.
Please
see the section titled “Material U.S. Federal Income Tax Consequences to U.S. Holders — Passive Foreign Investment
Company Rules” for a more detailed discussion with respect to our potential PFIC status. U.S. Holders are urged to consult their
tax advisors regarding the possible application of the PFIC rules to holders of our Class A Ordinary Shares.
If a United States person is treated as
owning at least 10% of our ordinary shares, such holder may be subject to adverse U.S. federal income tax consequences.
If a U.S. person is treated
as owning (directly, indirectly or constructively) at least 10% of the value or voting power of our ordinary shares, such U.S. person
may be treated as a “United States shareholder” with respect to each “controlled foreign corporation” in our
group (if any). We generally will be classified as a controlled foreign corporation if such United States shareholders own (directly,
indirectly or constructively) more than 50% of the value or voting power of our ordinary shares. Additionally, under certain “downward
attribution” rules, because our group includes U.S. subsidiaries, our non-U.S. subsidiaries could be treated as controlled foreign
corporations (regardless of whether we are treated as a controlled foreign corporation). A United States shareholder of a controlled
foreign corporation may be required to report annually and include in its U.S. taxable income its pro rata share of “Subpart F
income,” “global intangible low-taxed income” and investments in U.S. property by controlled foreign corporations,
regardless of whether we make any distributions. Subpart F income generally includes dividends,
interest, rents, royalties, gains from the sale of securities and income from certain transactions with related parties, and “global
intangible low-taxed income” generally consists of net tested income of the controlled foreign corporation, other than Subpart
F income and certain other types of income, in excess of certain thresholds. Failure to comply with these reporting obligations
may subject you to significant monetary penalties and may prevent the statute of limitations from starting with respect to your U.S.
federal income tax return for the year for which reporting was due. We cannot provide any assurances that we will assist investors in
determining whether any of our non-U.S. subsidiaries is treated as a controlled foreign corporation or whether such investor is treated
as a United States shareholder with respect to any of such controlled foreign corporations. Further, we cannot provide any assurances
that we will furnish to any United States shareholders information that may be necessary to comply with the aforementioned reporting
and tax payment obligations. U.S. holders of our ordinary shares should consult their tax advisors regarding the potential application
of these rules to their investment in our ordinary shares.
USE
OF PROCEEDS
We
may issue and sell up to $125,000,000 of our Class A Ordinary Shares from time to time. Because we are not required to sell
any Class A Ordinary Shares under the Sales Agreement, and any shares that may be sold pursuant to the Sales Agreement will be sold
in “at the market offerings” at fluctuating prices, the actual total public offering amount, commissions and proceeds to
us, if any, are not determinable at this time. There can be no assurance that we will sell any Class A Ordinary Shares under or
fully utilize the Sales Agreement as a source of financing.
We
intend to use the net proceeds from this offering as working capital and for general corporate purposes. General corporate purposes may
include, among other things, research and development, manufacturing and commercialization expenditures and strategic transactions.
As of the date of
this prospectus, we cannot specify with certainty all of the particular uses of the proceeds, if any, from this offering. Accordingly,
we will retain broad discretion over the use of any such proceeds. Pending the use of the net proceeds from this offering as described
above, we may invest the net proceeds.
DILUTION
If
you purchase Class A Ordinary Shares in this offering, your ownership interest will be diluted to the extent of the difference between
the purchase price per share and the as adjusted net tangible book value per share after giving effect to this offering. We calculate
net tangible book value per share by dividing the net tangible book value, which is total tangible assets less total liabilities, redeemable
noncontrolling interest and noncontrolling interest, by the number of Class A Ordinary Shares. Dilution represents the difference
between the portion of the amount per share paid by purchasers of Class A Ordinary Shares in this offering and the as adjusted net
tangible book value per share of Class A Ordinary Share immediately after giving effect to this offering. Our net tangible book
value as of June 30, 2024, was approximately $156.5 million, or $2.46 per share.
After
giving effect to the assumed sale of 31,017,369 Class A Ordinary Shares at a sale price
of $4.03 per share, the last sale price of our Class A Ordinary Shares on Nasdaq on
August 26, 2024, after deducting commissions and estimated aggregate offering expenses payable
by us, our as adjusted net tangible book value as of June 30, 2024, would have been $277.3
million, or $2.93 per share. This represents an immediate increase in the as adjusted net
tangible book value of $0.47 per share to our existing shareholders and an immediate dilution
of $1.10 per share to new investors purchasing shares in this offering. The following table
illustrates this per share dilution:
Assumed
offering price per share |
|
|
|
|
|
$ |
4.03 |
|
Net
tangible book value per share as of June 30, 2024 |
|
$ |
2.46 |
|
|
|
|
|
Increase
in net tangible book value per share attributable to new investors in offering |
|
$ |
0.47 |
|
|
|
|
|
As
adjusted net tangible book value per share as of June 30, 2024, after giving effect to this offering |
|
|
|
|
|
$ |
2.93 |
|
Dilution
per share to new investors in this offering |
|
|
|
|
|
$ |
1.10 |
|
Changes in the assumed public
offering price of $4.03 per share would not affect our as adjusted net tangible book value after this offering because this offering
is currently limited to $125,000,000. However, each $1.00 increase (decrease) in the assumed public offering price per share would increase
(decrease) the dilution per share to new investors by approximately $0.80 per share ($0.71) per share, assuming that the aggregate dollar
amount of shares offered by us, as set forth above, remains at $125,000,000 and after deducting the commissions and estimated offering
expenses payable by us. The information discussed above is illustrative only and will adjust based on the actual public offering price,
the actual number of shares that we offer in this offering, and other terms of this offering determined at the time of each offer and
sale.
The
number of Class A Ordinary Shares that will be outstanding after this offering is based on 63,683,806 Class A Ordinary
Shares outstanding as of June 30, 2024 and excludes as of June 30, 2024:
| · | options
to purchase an aggregate of 10,782,788 Class A Ordinary Shares issued to certain of
our directors, executives and employees, with a weighted average exercise price of $2.86
per share; |
| · | 1,442,473
Class A Ordinary Shares underlying restricted stock units issued to certain of our officers,
directors, employees, with a weighted average grant date fair value of $5.95 per share; |
| · | 2,000,000
Class A Ordinary Shares issuable upon exercise of the Z33 Series Seed Preferred
Shares Put Right; |
| · | 3,179,417
Class A Ordinary Shares reserved for future equity award grants under the 2023 Equity
Incentive Plan and 2023 Employee Stock Purchase Plan; |
| · | the
exchange of 6,703,428 public warrants and 4,080,580 private placement warrants on August 8,
2024, pursuant to our exchange offer and consent solicitation, and the mandatory exchange
of the remaining 196,568 public warrants and 1,829,420 private placement warrants on August 27,
2024; |
| · | 3,782,000
Class A Ordinary Shares issuable upon the exercise of the 2023 Pre-Funded Warrants and
16,102,348 Class A Ordinary Shares issuable upon the exercise of the 2024 Pre-Funded
Warrants, each with a weighted average exercise price of $0.001 per share; and |
| · | the
issuance of the Exchange Warrants to purchase 4,000,000 Class A Ordinary Shares, with a weighted
average exercise price of $0.001 per share. |
To the extent additional
shares have been or will be issued, including under the above securities, prices lower than the price of our Class A Ordinary Shares
in this offering, you will incur further dilution.
MATERIAL
U.S. FEDERAL INCOME TAX CONSEQUENCES TO U.S. HOLDERS
The following discussion
is a summary of the material U.S. federal income tax consequences to U.S. Holders (as defined below) of the ownership and disposition
of our Class A Ordinary Shares issued pursuant to this offering. It is not a comprehensive description of all tax considerations
that may be relevant to a particular person’s decision to acquire our Class A Ordinary Shares. The effects of any applicable
state, local, or non-U.S. laws, and U.S. federal non-income tax laws, such as estate and gift tax laws, are not discussed. This discussion
is based on the Code, U.S. Treasury regulations promulgated thereunder, judicial decisions, and published rulings and administrative
pronouncements of the U.S. Internal Revenue Service (the “IRS”), all as in effect as of the date of this prospectus. All
of the foregoing authorities are subject to change, which change could apply retroactively and could alter the tax consequences of the
ownership and disposition of our Class A Ordinary Shares described below. We have not sought and will not seek any rulings from
the IRS regarding the matters discussed below. There can be no assurance the IRS or a court will not take a contrary position to that
discussed below regarding the tax consequences of the ownership and disposition of our Class A Ordinary Shares.
This discussion is limited
to U.S. Holders that hold our Class A Ordinary Shares as capital assets within the meaning of Section 1221 of the Code (generally,
property held for investment). This discussion does not address all U.S. federal income tax consequences relevant to a U.S. Holder’s
particular circumstances, including the impact of the Medicare contribution tax on net investment income, the special tax accounting
rules under Section 451(b) of the Code, and the alternative minimum tax. In addition, this following discussion does not
address all U.S. federal income tax consequences relevant to U.S. Holders subject to particular rules, including, without limitation:
| · | U.S.
expatriates and certain former citizens or long-term residents of the United States; |
| · | persons
whose functional currency is not the U.S. dollar; |
| · | persons
holding our Class A Ordinary Shares as part of a hedge, straddle or other risk reduction
strategy or as part of a conversion transaction or other integrated investment; |
| · | banks,
insurance companies, and other financial institutions; |
| · | real
estate investment trusts or regulated investment companies; |
| · | brokers,
dealers, or traders in securities, commodities, or currencies; |
| · | S
corporations or partnerships or other entities or arrangements treated as partnerships for
U.S. federal income tax purposes (and investors therein); |
| · | tax-exempt
organizations or governmental organizations; |
| · | individual
retirement accounts or other tax deferred accounts; |
| · | persons
who acquired our Class A Ordinary Shares pursuant to the exercise of any employee share
option or otherwise as compensation; |
| · | persons
that own or are deemed to own 10% or more of our ordinary shares by vote or value; |
| · | persons
that own Founder Shares or warrants; |
| · | persons
deemed to see our Class A Ordinary Shares under the constructive sale provisions of
the Code; or |
| · | persons
that acquired our securities pursuant to an exercise of employee options, in connection with
employee share incentive plans or otherwise as compensation. |
If a partnership (or other
entity or arrangement treated as a partnership for U.S. federal income tax purposes) holds our Class A Ordinary Shares, the U.S.
federal income tax treatment of a partner in such partnership will depend on the status of the partner, the activities of the partnership,
and certain determinations made at the partner level. Partnerships holding our ordinary shares and the partners in such partnerships
should consult their tax advisors regarding the U.S. federal income tax consequences applicable to them.
U.S. HOLDERS ARE URGED
TO CONSULT THEIR TAX ADVISORS REGARDING THE APPLICATION OF THE U.S. FEDERAL TAX RULES TO THEIR PARTICULAR CIRCUMSTANCES AS WELL AS THE
PARTICULAR TAX CONSEQUENCES TO THEM OF THE PURCHASE, OWNERSHIP, AND DISPOSITION OF OUR ORDINARY SHARES, INCLUDING THE APPLICABILITY
AND EFFECT OF ANY STATE, LOCAL, AND NON-U.S. TAX LAWS, AS WELL AS OTHER U.S. FEDERAL TAX LAWS AND ANY APPLICABLE TAX TREATIES.
For purposes of this discussion,
a “U.S. Holder” is a beneficial owner of our ordinary shares that, for U.S. federal income tax purposes, is or is treated
as any of the following:
| · | an
individual who is a citizen or resident of the United States; |
| · | a
corporation (or other entity treated as a corporation for U.S. federal income tax purposes)
created or organized in or under the laws of the United States, any state therein, or the
District of Columbia; |
| · | an
estate, the income of which is subject to U.S. federal income tax regardless of its source;
or |
| · | a
trust that (1) is subject to the primary supervision of a U.S. court and the control
of one or more “United States persons” (within the meaning of Section 7701(a)(30)
of the Code), or (2) has a valid election in effect to be treated as a United States
person for U.S. federal income tax purposes. |
Taxation of Dividends and Other Distributions
on Our Class A Ordinary Shares
The
discussion in this section is subject to the discussion below under “—Passive Foreign Investment Company Rules”.
As discussed in the Prospectus
under “Description of Shares—Dividends,” we have not paid any cash dividends on our shares to date and do not expect
to pay cash dividends in the foreseeable future. In the event we do make distributions of cash or property, the gross amount of any such
distribution to U.S. Holders with respect to our Class A Ordinary Shares will be included in such holders’ gross income as
dividend income when actually or constructively received to the extent the distribution is paid out of our current or accumulated earnings
and profits (as determined under U.S. federal income tax principles). To the extent the amount of the distribution exceeds our current
and accumulated earnings and profits, it will be treated first as a return of capital that will be applied against and reduce (but not
below zero) the U.S. Holder’s tax basis in the Class A Ordinary Shares, and any remaining excess will be treated as gain realized
on the sale or other disposition of the Class A Ordinary Shares and will be taxed as described below under the heading “—Sale
or Other Taxable Disposition of Our Class A Ordinary Shares.” We cannot provide any assurance that we will maintain or provide
earnings and profits determinations in accordance with U.S. federal income tax principles. Therefore, a U.S. Holder should expect that
distributions may be reported as dividend income for such purposes. Dividends we pay will not be eligible for the dividends-received
deduction available to corporations in respect of dividends received from U.S. corporations.
Subject to certain limitations,
dividends paid by qualified foreign corporations to certain non-corporate U.S. Holders may be taxable at preferential tax rates. A non-U.S.
corporation is generally treated as a qualified foreign corporation with respect to dividends paid on stock that is readily tradable
on a securities market in the United States, such as the Nasdaq Capital Market on which our ordinary shares are listed, and we are not
treated as a PFIC with respect to such U.S. Holder at the time the dividend was paid or in the preceding year, and provided certain holding
periods are met. There can be no assurance that our ordinary shares are, or will continue to be, readily tradable on an established securities
exchange. Consequently, there can be no assurance that dividends paid on our Class A Ordinary Shares will be afforded the reduced
tax rates. Non-corporate U.S. Holders should consult their tax advisers regarding the availability of the reduced tax rate on dividends.
Dividends will be included in a U.S. Holder’s income on the date of the U.S. Holder’s receipt of the dividend.
Our dividends generally
will constitute foreign source income for foreign tax credit limitation purposes. Any tax withheld with respect to distributions on the
ordinary shares may, subject to a number of complex limitations, be claimed as a foreign tax credit against such U.S. Holder’s
U.S. federal income tax liability or, at such U.S. Holder’s election, may be claimed as a deduction for U.S. federal income tax
purposes. An election to deduct foreign taxes instead of claiming a foreign tax credit applies to all foreign taxes paid or accrued in
the taxable year. The limitation on foreign taxes eligible for a credit is calculated separately with respect to specific classes of
income. For this purpose, dividends distributed by us with respect to the Class A Ordinary Shares generally will constitute “passive
category income.” The rules with respect to the foreign tax credit are complex and may depend upon a U.S. Holder’s particular
circumstances, there are significant and complex limits on a U.S. Holder’s ability to claim foreign tax credits, and recently released
U.S. Treasury regulations may in some circumstances prohibit a U.S. Holder from claiming a foreign tax credit with respect to certain
non-U.S. taxes that are not creditable under applicable income tax treaties. U.S. Holders should consult their tax advisors regarding
the availability of the foreign tax credit in light of their particular circumstances.
Sale or Other Taxable Disposition of Our Class A
Ordinary Shares
The
discussion in this section is subject to the discussion below under “—Passive Foreign Investment Company Rules”.
A U.S. Holder will recognize
gain or loss on any sale, exchange or other taxable disposition of our Class A Ordinary Shares equal to the difference between (i) the
sum of (x) the amount of cash and (y) the fair market value of any other property received in such sale, exchange or other
taxable disposition and (ii) the U.S. Holder’s adjusted tax basis in such Class A Ordinary Shares, in each case as calculated
in U.S. dollars. Any such gain or loss will be capital gain or loss, and will be long-term capital gain or loss if such U.S. Holder held
the Class A Ordinary Shares for more than one year at the time of the disposition. Long-term capital gains recognized by certain
non-corporate U.S. Holders, including individuals, generally are taxed at reduced rates under current law. The deductibility of capital
losses is subject to limitations. Any such gain or loss a U.S. Holder recognizes generally will be treated as U.S. source income or loss
for foreign tax credit limitation purposes. U.S. Holders should consult their tax advisors regarding the proper treatment of gain or
loss in their particular circumstances.
U.S. Holders should consult
their tax advisors regarding the proper treatment of gain or loss in their particular circumstances.
Passive Foreign Investment Company Rules
The treatment of U.S. Holders
of our Class A Ordinary Shares purchased in this offering could be materially different from that described above if we are treated
as a PFIC for U.S. federal income tax purposes. U.S. Holders are urged to consult with their tax advisors regarding the treatment of
our Class A Ordinary Shares if we were characterized as a PFIC.
A non-U.S. corporation will
be classified as a PFIC for any taxable year in which, after applying certain look-through rules, either:
| · | at
least 75% of its gross income for such taxable year is passive income, or |
| · | at
least 50% of the value of its assets (based on an average of the quarterly values of the
assets during a taxable year) is attributable to assets that produce or are held for the
production of passive income. |
For
purposes of the above calculations, if a non-U.S. corporation owns, directly or indirectly,
25% or more of the total value of the outstanding shares of another corporation, it will
be treated as if it (a) held a proportionate share of the assets of such other corporation
and (b) received directly a proportionate share of the income of such other corporation.
Passive income generally includes dividends, interest, rents, royalties and capital gains,
but generally excludes rents and royalties which are derived in the active conduct of a trade
or business and which are received from a person other than a related person. We believe
we were a PFIC within the meaning of Section 1297 of the Code for our most recently completed
taxable year and based on the nature of our business, the projected composition of our gross
income and the projected composition and estimated fair market values of our assets, we expect
to be a PFIC for our current taxable year and may be a PFIC in subsequent taxable years.
No opinion of legal counsel or ruling from the IRS concerning our status as a PFIC has been
obtained or is currently planned to be requested. There can be no assurance regarding our
PFIC status for the current taxable year or any subsequent taxable year, because PFIC status
is determined annually and requires a factual determination that depends on, among other
things, the composition of a company’s income, assets and activities in each taxable
year, and can only be made annually after the close of each taxable year, and is thus subject
to significant uncertainty. Furthermore, the value of our gross assets is likely to be determined
in part by reference to our market capitalization, which may fluctuate significantly. Accordingly,
there can be no assurances about our PFIC status for our current or any future taxable year,
and our U.S. counsel expresses no opinion with respect to our PFIC status for any taxable
year.
A separate determination
must be made with respect to each taxable year as to whether we are a PFIC (after the close of each such taxable year). As a result,
our PFIC status may change. Because the value of our assets for purposes of the asset test (including goodwill) will generally be determined
by reference to the market price of our Class A Ordinary Shares, our PFIC status will depend in large part on the market price of
our Class A Ordinary Shares, which may fluctuate significantly. In addition, changes in the composition of our income or assets
may cause us to become a PFIC, including by how, and how quickly we spend the cash we raise in any offering, including this offering.
Finally, until such time as we start generating material revenue from operations, our PFIC status may depend, in part or in full, on
the treatment of payments we receive from other sources (including tax credits), which is uncertain, and the magnitude of such payments
compared to passive income from investments.
If we are classified as
a PFIC in any taxable year with respect to which a U.S. Holder owns our Class A Ordinary Shares, we will continue to be treated
as a PFIC with respect to such U.S. Holder in all succeeding years during which the U.S. Holder owns our Class A Ordinary Shares,
regardless of whether we continue to meet the tests described above unless (1) we cease to be a PFIC and the U.S. Holder has made
a “deemed sale” election under the PFIC rules, or (2) the U.S. Holder makes a QEF Election (as defined below) with respect
to all taxable years in which we are a PFIC during the U.S. Holder’s holding period or makes a purging election to cause a
deemed sale of our Class A Ordinary Shares at their fair market value in conjunction with a QEF Election. If a deemed sale election
is made, the U.S. Holder will be deemed to have sold our Class A Ordinary Shares it holds at their fair market value and any gain
from such deemed sale would be subject to the rules described below. After the deemed sale election, so long as we do not become
a PFIC in a subsequent taxable year, the Class A Ordinary Shares with respect to which such election was made will not be treated
as shares in a PFIC and the U.S. Holder will not be subject to the rules described below with respect to any “excess distribution”
it receives from us or any gain from an actual sale or other disposition of our Class A Ordinary Shares. If we are treated as a
PFIC with respect to a U.S. Holder, and subsequently cease to be a PFIC, such U.S. Holder should consult its tax advisors as to the possibility
and consequences of making a deemed sale election.
If we are treated as a PFIC
for any taxable year during which a U.S. Holder holds our Class A Ordinary Shares, such holder will be subject to special tax rules with
respect to any “excess distribution” received and any gain recognized from a sale or other disposition (including a pledge)
of our Class A Ordinary Shares, unless such holder makes a QEF Election or a mark-to-market election as discussed below. Distributions
a U.S. Holder receives in a taxable year that are greater than 125% of the average annual distributions such holder received during the
shorter of the three preceding taxable years or such holder’s holding period for the Class A Ordinary Shares will be
treated as an excess distribution. Under these special tax rules, if a U.S. Holder receives any excess distribution or realizes any gain
from a sale or other disposition of the Class A Ordinary Shares:
| · | the
excess distribution or gain will be allocated ratably over such holder’s holding period
for our Class A Ordinary Shares, |
| · | the
amount allocated to the current taxable year, and any taxable year before the first taxable
year in which we were a PFIC, will be taxed as ordinary income, and |
| · | the
amount allocated to each other year will be subject to the highest tax rate in effect for
that year and the interest charge generally applicable to underpayments of tax will be imposed
on the resulting tax attributable to each such year. |
The tax liability for amounts
allocated to years before the year of disposition or “excess distribution” cannot be offset by any net operating losses
for such years, and gains (but not losses) realized on the sale or other taxable disposition of our Class A Ordinary Shares
cannot be treated as capital gains.
If
we are a PFIC, a U.S. Holder generally will be subject to similar rules with respect
to distributions we receive from, and our dispositions of the stock of, any of our direct
or indirect subsidiaries or any other entities in which we hold equity interests that also
are PFICs, or lower-tier PFICs, as if such U.S. Holder held its proportionate share of the
stock of such lower-tier PFICs directly. We will endeavor, upon written request by a U.S.
Holder, to cause any lower-tier PFIC to provide or make available to such U.S. Holder such
information as the IRS may require to make or maintain a QEF Election (described below) with
respect to the lower-tier PFIC. However, there is no assurance that we will have timely knowledge
of the status of any such lower-tier PFIC. In addition, we may not hold a controlling interest
in any such lower-tier PFIC and thus there can be no assurance we will be able to cause the
lower-tier PFIC to provide the required information. U.S. Holders should consult their tax
advisors regarding the application of the PFIC rules to lower-tier PFICs.
Certain elections may be
available that would result in alternative treatments (such as mark-to-market treatment of our Class A Ordinary Shares). U.S. Holders
can avoid the interest charge on excess distributions or gain relating to our Class A Ordinary Shares by making a mark-to-market
election with respect to the Class A Ordinary Shares, provided that the Class A Ordinary Shares are “marketable stock.”
Our Class A Ordinary Shares will be marketable stock if they are “regularly traded” on certain U.S. stock exchanges
or on a non-U.S. stock exchange that meets certain conditions. For these purposes, the Class A Ordinary Shares will be considered
regularly traded during any calendar year during which they are traded, other than in de minimis quantities, on at least 15 days
during each calendar quarter. Any trades that have as one of their principal purposes meeting this requirement will be disregarded. Our
Class A Ordinary Shares will be listed on Nasdaq , which is a qualified exchange for these purposes. Consequently, if our Class A
Ordinary Shares remain listed on Nasdaq and are “regularly traded”, the mark-to-market election may be available to U.S.
Holders. However, a mark-to-market election generally cannot be made for equity interests in any lower-tier PFICs that we own, unless
shares of such lower-tier PFIC are themselves marketable stock. As a result, even if a U.S. Holder validly makes a mark-to-market election
with respect to our Class A Ordinary Shares, the U.S. Holder may continue to be subject to the rules described above with respect
to any “excess distribution” in respect of its indirect interest in any of our investments that are treated as an equity
interest in a PFIC for U.S. federal income tax purposes. A U.S. Holder that is eligible to make a mark-to-market with respect to such
Holder’s Class A Ordinary Shares may do so by providing the appropriate information on IRS Form 8621 and timely filing
that form with the U.S. Holder’s tax return for the year in which the election becomes effective. Each U.S. Holder should consult
its tax advisor as to the whether a mark-to-market election is available or advisable with respect to our Class A Ordinary Shares,
as well as the impact of such election on interests in any lower-tier PFICs.
The
adverse consequences of owning stock in a PFIC could also be mitigated if a U.S. Holder makes
a valid “qualified electing fund” election (“QEF Election”), which,
among other things, would require a U.S. Holder to include currently in income its pro rata
share of the PFIC’s net capital gains (as long-term capital gain) and other earnings
and profits (as ordinary income), on a current basis, in each case whether or not distributed,
in the taxable year of the U.S. Holder in which or with which the PFIC’s taxable year
ends. A U.S. Holder generally may make a separate election to defer the payment of taxes
on undistributed income inclusions under the QEF rules, but if deferred, any such taxes will
be subject to an interest charge.
In order to comply with
the requirements of a QEF election, a U.S. Holder must receive a PFIC Annual Information Statement from the PFIC. If we determine that
we are a PFIC for a taxable year, upon written request by a U.S. Holder, we will endeavor to provide or make available to the requesting
U.S. Holder such information as the IRS may require to enable such U.S. Holder to make and maintain a QEF Election with respect to our
Class A Ordinary Shares, including the PFIC Annual Information Statement for the tax year, which may include a statement that we permitted
such U.S. Holder to examine our books of account, records, and other documents to calculate the amounts of the our ordinary earnings
and the net capital gain according to U.S. federal income tax accounting principles and to calculate such U.S. Holder’s pro rata
shares of our ordinary earnings and net capital gain. However, there is no assurance that we will have timely knowledge of our status
as a PFIC or that the required information will be provided, and, in any event, such election may be unavailable with respect to an owner
of our warrants.
The QEF Election is made
on a shareholder-by-shareholder basis and, once made, can be revoked only with the consent of the IRS. A U.S. Holder generally makes
a QEF Election by attaching a completed IRS Form 8621, including the information provided in a PFIC Annual Information Statement, to
a timely filed U.S. federal income tax return for the tax year to which the election relates. Retroactive QEF Elections generally may
be made only in very limited circumstances or with the consent of the IRS. U.S. Holders should consult their own tax advisors regarding
the availability and tax consequences of a retroactive QEF Election under their particular circumstances.
If a U.S. Holder has made
a QEF Election with respect to our Class A Ordinary Shares, and the special tax and interest charge rules do not apply to such shares
(because of a timely QEF Election for our first taxable year as a PFIC in which the U.S. Holder holds (or is deemed to hold) such shares
or a purge of the PFIC taint pursuant to a purging election, as described above), any gain recognized on the sale of our Class A Ordinary
Shares generally will be taxable as capital gain and no interest charge will be imposed under the PFIC rules. As discussed above, if
we are a PFIC for any taxable year, a U.S. Holder of our Class A Ordinary Shares that has made a QEF Election will be currently taxed
on its pro rata share of our earnings and profits, whether or not distributed for such year. In such case, a subsequent distribution
of such earnings and profits that were previously included in income generally should not be taxable when distributed to such U.S. Holders.
The tax basis of a U.S. Holder’s shares in a PFIC with respect to which the U.S. Holder has made a valid QEF Election will be increased
by amounts that are included in income. and decreased by amounts distributed but not taxed as dividends, under the above rules.
If we are considered a PFIC,
U.S. Holders may also be subject to annual information reporting requirements. A U.S. Holder’s failure to file the annual report
may result in substantial penalties and extend the statute of limitations with respect to the U.S. Holder’s federal income tax
return. If we are or become a PFIC, U.S. Holders should consult their tax advisors regarding any reporting requirements that may apply
to them.
U.S. Holders are urged to
consult their tax advisors regarding the application of the PFIC rules to the ownership and disposition of our Class A Ordinary
Shares and the potential availability of a mark-to-market or QEF election.
Information Reporting and Backup Withholding
Dividend payments with respect
to our Class A Ordinary Shares and proceeds from the sale, exchange, or other taxable disposition of our Class A Ordinary Shares
may be subject to information reporting to the IRS and U.S. backup withholding. Certain U.S. Holders are exempt from backup withholding,
including corporations and certain tax-exempt organizations. A U.S. Holder will be subject to backup withholding if such holder is not
a corporation or otherwise exempt and such holder:
| · | fails
to furnish the holder’s taxpayer identification number, which for an individual is
ordinarily such individual’s social security number; |
| · | furnishes
an incorrect taxpayer identification number; |
| · | is
notified by the IRS that the holder previously failed to properly report payments of interest
or dividends; or |
| · | fails
to certify under penalties of perjury that the holder has furnished a correct taxpayer identification
number and that the IRS has not notified the holder that the holder is subject to backup
withholding. |
Backup withholding is not
an additional tax. Any amounts withheld under the backup withholding rules may be allowed as a refund or a credit against the U.S.
Holder’s U.S. federal income tax liability, provided the required information is timely furnished to the IRS. U.S. Holders should
consult their tax advisors regarding their qualification for an exemption from backup withholding and the procedures for obtaining such
an exemption.
Additional Reporting Requirements
Certain U.S. Holders who
are individuals (and certain entities) that hold an interest in “specified foreign financial assets” (which may include our
Class A Ordinary Shares) are required to report information relating to such assets, subject to certain exceptions (including an
exception for our Class A Ordinary Shares held in accounts maintained by certain U.S. financial institutions). Substantial penalties
apply if U.S. Holders fail to satisfy such reporting requirements. U.S. Holders should consult their tax advisors regarding the applicability
of these requirements to their acquisition, ownership, and disposition of our Class A Ordinary Shares.
PLAN
OF DISTRIBUTION
We
have entered into a Sales Agreement with Leerink Partners, under which we may issue and sell
from time to time our Class A Ordinary Shares through Leerink Partners as our sales agent.
Pursuant to this prospectus, we may issue and sell up to an aggregate of $125,000,000 of
our Class A Ordinary Shares. Sales of our Class A Ordinary Shares, if any, will be made
at market prices by any method that is deemed to be an “at the market offering”
as defined in Rule 415(a)(4) under the Securities Act, including sales made directly on Nasdaq
or any other trading market for our Class A Ordinary Shares. The Sales Agreement will be
filed as an exhibit to the registration statement of which this prospectus is a part. The
below description of the material provisions of the Sales Agreement does not purport to be
a complete statement of its terms and conditions.
Leerink
Partners will offer our Class A Ordinary Shares subject to the terms and conditions of the
Sales Agreement on a daily basis or as otherwise agreed upon by us and Leerink Partners.
We will designate the maximum amount of Class A Ordinary Shares to be sold through Leerink
Partners on a daily basis or otherwise determine such maximum amount together with Leerink
Partners. Subject to the terms and conditions of the Sales Agreement, Leerink Partners will
use commercially reasonable efforts consistent with its normal trading and sales practices
to sell such shares up to the amount specified on such terms. We may instruct Leerink Partners
not to sell Class A Ordinary Shares if the sales cannot be effected at or above the
price designated by us in any such instruction. Leerink Partners or we may suspend the offering
of our Class A Ordinary Shares being made through Leerink Partners under the Sales Agreement
upon proper notice to the other parties. Leerink Partners and we each have the right, by
giving written notice as specified in the Sales Agreement, to terminate the Sales Agreement
in each party’s sole discretion at any time.
The
aggregate compensation payable to Leerink Partners as sales agent equal to 3.0% of the gross
sales price of the shares sold through them pursuant to the Sales Agreement. We have also
agreed to reimburse Leerink Partners for up to $75,000 of the actual outside legal expenses
incurred by Leerink Partners in connection with the establishment of the at-the-market offering,
and thereafter. $15,000 on a quarterly basis, and up to $10,000 of filing fees and associated
legal expenses of Leerink Partners’ outside counsel for filings with the Financial
Industry Regulatory Authority Corporate Financing Department in connection with the transactions
contemplated by the Sales Agreement. We estimate that the total expenses in connection with
the transactions contemplated by the Sales Agreement payable by us, excluding commissions
payable to Leerink Partners under the Sales Agreement, will be approximately $450,000.
The remaining sales proceeds,
after deducting any expenses payable by us and any transaction fees imposed by any governmental, regulatory, or self-regulatory organization
in connection with the sales, will equal our net proceeds for the sale of such Class A Ordinary Shares.
Leerink Partners will provide
written confirmation to us following the close of trading on Nasdaq on each day in which Class A Ordinary Shares are sold through them
as sales agent under the Sales Agreement. Each confirmation will include the number of Class A Ordinary Shares sold through Leerink Partners
as sales agent on that day, the volume weighted average price of the shares sold, the percentage of the daily trading volume and the
net proceeds to us.
We will report at least
quarterly the number of Class A Ordinary Shares sold through Leerink Partners under the Sales Agreement, the net proceeds to us and the
compensation paid by us to Leerink Partners in connection with the sales Class A Ordinary Shares. Settlement for sales of Class A
Ordinary Shares will occur, unless the parties agree otherwise, on the first business day that is also a trading day following the date
on which any sales were made in return for payment of the net proceeds to us.There is no arrangement for funds to be received in an escrow,
trust or similar arrangement.
In
connection with the sales of our Class A Ordinary Shares on our behalf, Leerink Partners will be deemed to be an “underwriter”
within the meaning of the Securities Act, and the compensation paid to Leerink Partners will be deemed to be underwriting commissions
or discounts. We have agreed in the Sales Agreement to provide indemnification and contribution to Leerink Partners against certain liabilities,
including liabilities under the Securities Act.
As sales agent, Leerink
Partners will not engage in any transactions that stabilize our Class A Ordinary Shares.
Our Class A Ordinary
Shares are listed and traded on Nasdaq under the symbol “ZURA.” The transfer agent and registrar of our Class A Ordinary
Shares is Continental Stock Transfer & Trust Company.
LEGAL
MATTERS
Certain
matters with respect to U.S. federal and New York State law will be passed upon for us by Cooley LLP, New York, New York. Ogier
(Cayman) LLP, Cayman Islands, will pass upon the validity of the securities offered in this prospectus with respect to the Class A
Ordinary Shares and matters of Cayman Islands law. The sales agent is being represented in connection with this offering by White &
Case LLP, New York, New York.
EXPERTS
The financial statements
appearing in our Annual
Report on Form 10-K for the year ended December 31, 2023 have been audited by WithumSmith+Brown, PC (“Withum”),
independent registered public accountants, as set forth in their report thereon, included therein, and incorporated herein by reference.
The financial statements are incorporated herein by reference in reliance upon such report given on the authority of said firm as experts
in accounting and auditing.
WHERE
YOU CAN FIND MORE INFORMATION
We are subject to the information
reporting requirements of the Exchange Act, and we file reports, proxy statements, and other information with the SEC. These reports,
proxy statements, and other information will be available for review at the SEC’s website at www.sec.gov. We also maintain a website
at www.zurabio.com, at which you may access these materials free of charge as soon as reasonably practicable after they are electronically
filed with, or furnished to, the SEC. The information contained in, or that can be accessed through, our website is not part of this
prospectus.
Our website address is www.zurabio.com.
Through our website, we make available, free of charge, the following documents as soon as reasonably practicable after they are electronically
filed with, or furnished to, the SEC, including our Annual Reports on Form 10-K; our proxy statements for our annual and extraordinary
shareholder meetings; our Quarterly Reports on Form 10-Q; our Current Reports on Form 8-K; Forms 3, 4, and 5 and Schedules
13D with respect to our securities filed on behalf of our directors and our executive officers; and amendments to those documents. The
information contained on, or that may be accessed through, our website is not a part of, and is not incorporated into, this prospectus.
INCORPORATION
OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to “incorporate
by reference” information into this prospectus from other documents that we file with the SEC, which means that we can disclose
important information to you by referring you to those documents. The information incorporated by reference is considered to be part
of this prospectus and information we file later with the SEC will automatically update and supersede this information. Any statement
contained in this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for
purposes of this prospectus to the extent that a statement contained in this prospectus or a subsequently filed document incorporated
by reference modifies or replaces that statement. The documents we are incorporating by reference as of their respective dates of filing
are (in each case, other than those documents or the portions of those documents not deemed to be filed, including the portions of these
documents that are furnished under Item 2.02 or Item 7.01 of a Current Report on Form 8-K, including any exhibits included
with such Items):
| · | our
Annual Report on Form 10-K for the year ended December 31, 2023, filed with
the SEC on March 28,
2024; |
| · | our
Quarterly Reports on Form 10-Q for the quarters ended March 31, 2024, filed with
the SEC on May 9,
2024, and amended by Amendment No. 1 to the Quarterly Report on Form 10-Q filed
with the SEC on May 15,
2024, and June 30, 2024, filed with the SEC on August 13,
2024; |
Notwithstanding the foregoing,
information furnished under Items 2.02 and 7.01 of any Current Report on Form 8-K, including the related exhibits under Item
9.01, is not incorporated by reference in this prospectus or any prospectus supplement.
All
documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than
those documents or the portions of those documents not deemed to be filed, including the portions of these documents that are furnished
under Item 2.02 or Item 7.01 of a Current Report on Form 8-K, including any exhibits included with such Items), prior to the
termination of this offering, including all such documents we may file after the date of the initial registration statement of which
this prospectus forms a part and prior to the effectiveness of the registration statement, but excluding any information furnished
to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus
from the date of the filing of such reports and documents.
You
may obtain any of the documents incorporated by reference in this prospectus from the SEC through the SEC’s website at the address
provided above. You also may request a copy of any document incorporated by reference in this prospectus (excluding any exhibits
to those documents, unless the exhibit is specifically incorporated by reference in this document), at no cost, by writing or telephoning
us at the following address and phone number:
Zura Bio Limited
1489 W. Warm Springs
Rd. #110
Henderson, NV 89014
Attn: General Counsel
(702) 825-9872
ZURA BIO LIMITED
Up to $125,000,000
Class A
Ordinary Shares
PROSPECTUS
Leerink Partners
,
2024
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution
The following table sets
forth the estimated costs and expenses, other than underwriting discounts and commissions, payable by us in connection with the offering
of the securities being registered. All the amounts shown are estimates, except for the SEC registration fee and FINRA filing fee.
SEC registration
fee |
|
$ |
44,280 |
|
Financial Industry Regulatory
Authority, Inc. filing fee |
|
|
45,500 |
|
Accounting fees and expenses |
|
|
* |
|
Legal fees and expenses |
|
|
* |
|
Transfer agent fees and
expenses |
|
|
* |
|
Trustee fees and expenses |
|
|
* |
|
Printing and miscellaneous
expenses |
|
|
* |
|
Total |
|
$ |
* |
|
| * | These fees are calculated based on the securities
offered and the number of issuances and accordingly cannot be estimated at this time. |
Item 15. Indemnification of Directors and
Officers
Cayman Islands law does
not limit the extent to which a company’s memorandum and articles of association may provide for indemnification of officers and
directors, except to the extent any such provision may be held by the Cayman Islands courts to be contrary to public policy, such as
to provide indemnification against willful default, willful neglect, fraud or the consequences of committing a crime. The MAA provide
for indemnification of our current and former officers and directors to the maximum extent permitted by law, including for any liability
incurred in their capacities as such, except through their own actual fraud, willful default or willful neglect.
We have entered into indemnification
agreements with each of our officers and directors a form of which is filed as Exhibit 10.4 to our registration statement on Form S-1
that was declared effective by the SEC on July 13, 2021. These agreements require us to indemnify these individuals to the fullest
extent permitted under Cayman Islands law against liabilities that may arise by reason of their service to us, and to advance expenses
incurred as a result of any proceeding against them as to which they could be indemnified.
Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling us pursuant to the foregoing
provisions, we have been informed that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities
Act and is theretofore unenforceable.
Effective immediately upon
the consummation of the Business Combination, the Company entered into indemnification agreements with each of the newly elected directors
and newly appointed executive officers which provide that the Company will indemnify such directors and executive officers under the
circumstances and to the extent provided for therein, from and against all losses, claims, damages, liabilities, joint or several, expenses
(including legal fees and expenses), judgments, fines, penalties, interest, settlements or other amounts arising from any and all threatened,
pending or completed claim, demand, action, suit or proceeding, whether civil, criminal, administrative or investigative, and whether
formal or informal, and including appeals, in which he or she may be involved, or is threatened to be involved, as a party or otherwise,
to the fullest extent permitted under the laws of the Cayman Islands and our Second Amended and Restated Memorandum and Articles of Association.
Item 16. Exhibits
Exhibit
Number |
|
Exhibit Description |
|
|
|
|
1.1* |
|
Form of Underwriting
Agreement. |
|
|
|
|
|
1.2+ |
|
Sales Agreement, by and
between Zura Bio Limited and Leerink Partners LLC, dated September 3, 2024. |
|
|
|
|
|
2.1 |
|
Business
Combination Agreement, dated as of June 16, 2022, by and among JATT, Merger Sub, Merger Sub 2, Holdco and Zura Bio Limited (incorporated
by reference to Exhibit 2.1 of JATT’s Current Report on Form 8-K (File No. 001-40598), filed with the SEC on
June 17, 2022). |
|
|
|
|
|
3.1 |
|
Second
Amended and Restated Memorandum and Articles of Association of Zura Bio Limited (incorporated by reference to Exhibit 3.1 to
Zura’s Form 8-K (File No. 001-40598), filed with the SEC on March 24, 2023). |
|
|
|
|
|
4.1 |
|
Specimen
Share Certificate of Zura (incorporated by reference to Exhibit 4.5 of JATT’s Form S-4 (File No. 333-267005)
filed with the SEC on August 19, 2022). |
|
|
|
|
|
4.2* |
|
Form of Specimen
Certificate Representing Preferred Shares. |
|
|
|
|
|
4.3+ |
|
Form of
Indenture. |
|
|
|
|
|
4.4* |
|
Form of Warrant. |
|
|
|
|
|
4.5* |
|
Form of Warrant Agreement. |
|
|
|
|
|
4.6* |
|
Form of Unit Agreement. |
|
|
|
|
|
5.1+ |
|
Opinion
of Ogier (Cayman) LLP. |
|
|
|
|
|
5.2+ |
|
Opinion
of Cooley, LLP. |
|
|
|
|
|
23.1+ |
|
Consent
of WithumSmith+Brown, PC, independent registered public accounting firm of Zura. |
|
|
|
|
|
23.2+ |
|
Consent
of Ogier (Cayman) LLP (included in Exhibit 5.1). |
|
|
|
|
|
23.3+ |
|
Consent
of Cooley, LLP (included in Exhibit 5.2). |
|
|
|
|
|
24.1 |
|
Power
of Attorney (included on signature page to this prospectus). |
|
|
|
|
|
107+ |
|
Filing
Fee Table |
|
|
|
|
|
* To be filed
by amendment or by a report filed under the Exchange Act and incorporated herein by reference, if applicable.
+ Filed herewith.
Item 17. Undertakings
| (a) | The undersigned Registrant hereby undertakes
as follows: |
| (1) | To file, during any period in which offers
or sales are being made, a post-effective amendment to this registration statement: |
| (i) | To include any prospectus required by Section 10(a)(3) of
the Securities Act of 1933; |
| (ii) | To reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental
change in the information set forth in the registration statement. Notwithstanding the foregoing,
any increase or decrease in volume of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed
with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in
volume and price represent no more than 20 percent change in the maximum aggregate offering
price set forth in the “Calculation of Registration Fee” table in the effective
registration statement; |
| (iii) | To include any material information with
respect to the plan of distribution not previously disclosed in the registration statement
or any material change to such information in the registration statement. |
provided,
however, that:
Paragraphs
(i), (ii) and (iii) do not apply if the registration statement is on Form S-3 and the information required to be included
in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant
pursuant to Section 13 or Section 15(d) of the Securities and Exchange Act of 1934, as amended (the “Exchange Act”),
that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that
is part of the Registration Statement.
| (2) | That, for the purpose of determining
any liability under the Securities Act of 1933, each such post-effective amendment shall
be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof. |
| (3) | To remove from registration by means
of a post-effective amendment any of the securities being registered which remain unsold
at the termination of the offering. |
| (4) | That, for the purpose of determining
liability under the Securities Act of 1933 to any purchaser, each prospectus filed pursuant
to Rule 424(b) as part of a registration statement relating to an offering, other
than registration statements relying on Rule 430B or other than prospectuses filed in
reliance on Rule 430A, shall be deemed to be part of and included in the registration
statement as of the date it is first used after effectiveness. Provided, however, that no
statement made in a registration statement or prospectus that is part of the registration
statement or made in a document incorporated or deemed incorporated by reference into the
registration statement or prospectus that is part of the registration statement will, as
to a purchaser with a time of contract of sale prior to such first use, supersede or modify
any statement that was made in the registration statement or prospectus that was part of
the registration statement or made in any such document immediately prior to such date of
first use. |
| (5) | That,
for the purpose of determining any liability under the Securities Act of 1933 to any purchaser
in the initial distribution of the securities, the undersigned registrant undertakes
that in a primary offering of securities of the undersigned registrant pursuant to this registration
statement, regardless of the underwriting method used to sell the securities to the purchaser,
if the securities are offered or sold to such purchaser by means of any of the following
communications, the undersigned registrant will be a seller to the purchaser and will be
considered to offer or sell such securities to such purchaser: |
| (i) | Any preliminary prospectus or prospectus
of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424; |
| (ii) | Any free writing prospectus relating to
the offering prepared by or on behalf of the undersigned registrant or used or referred to
by the undersigned registrant; |
| (iii) | The portion of any other free writing
prospectus relating to the offering containing material information about the undersigned
registrant or our securities provided by or on behalf of the undersigned registrant; and |
| (iv) | Any other communication that is an offer
in the offering made by the undersigned registrant to the purchaser. |
| (b) | The
undersigned registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the registrant’s annual report pursuant to
section 13(a) or section 15(d) of the Exchange Act (and, where applicable, each
filing of an employee benefit plan’s annual report pursuant to section 15(d) of
the Exchange Act), that is incorporated by reference in the registration statement shall
be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof. |
| (h) | Insofar as indemnification for liabilities
arising under the Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the undersigned pursuant to the foregoing provisions, or otherwise, the undersigned
has been advised that in the opinion of the SEC such indemnification is against public policy
as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
claim for indemnification against such liabilities (other than the payment by the undersigned
of expenses incurred or paid by a director, officer or controlling person of the undersigned
in the successful defense of any action, suit or proceeding) is asserted by such director,
officer or controlling person in connection with the securities being registered, the undersigned
will, unless in the opinion of our counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such indemnification by
it is against public policy as expressed in the Act and will be governed by the final adjudication
of such issue. |
| (i) | The
undersigned registrant hereby undertakes to file an application for the purpose of determining
the eligibility of the trustee to act under subsection (a) of section 310 of the Trust
Indenture Act (“Act”) in accordance with the rules and regulations prescribed
by the Commission under section 305(b)(2) of the Act. |
SIGNATURES
Pursuant
to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the
undersigned, thereunto duly authorized, on the 3rd day of September, 2024.
|
Zura Bio
Limited |
|
|
|
|
By: |
/s/
Robert Lisicki |
|
|
Name: Robert Lisicki |
|
|
Title: Chief Executive
Officer |
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below hereby constitutes and appoints Verender S. Badial and Kim Davis, and each of
them, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution and resubstitution, for him or
her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments,
to this Post-Effective Amendment, and any registration statement relating to the offering covered by this registration statement and
filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully for all intents
and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents,
or his or her substitute or substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements
of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
indicated.
Name |
|
Title |
|
Date |
|
|
|
|
|
/s/
Robert Lisicki |
|
Chief
Executive Officer and Director |
|
September 3, 2024 |
Robert Lisicki |
|
(Principal
Executive Officer) |
|
|
|
|
|
|
|
/s/
Verender S. Badial |
|
Chief
Financial Officer and Secretary |
|
September 3, 2024 |
Verender S. Badial |
|
(Principal
Financial and Accounting Officer) |
|
|
|
|
|
|
|
/s/
Amit Munshi |
|
Chairman
of the Board |
|
September 3, 2024 |
Amit Munshi |
|
|
|
|
|
|
|
|
|
/s/
Sandeep Kulkarni |
|
Director |
|
September 3, 2024 |
Sandeep Kulkarni |
|
|
|
|
|
|
|
|
|
/s/
Arnout Ploos van Amstel |
|
Director |
|
September 3, 2024 |
Arnout Ploos van
Amstel |
|
|
|
|
|
|
|
|
|
/s/
Steve Schoch |
|
Director |
|
September 3, 2024 |
Steve Schoch |
|
|
|
|
|
|
|
|
|
/s/
Jennifer Jarrett |
|
Director |
|
September 3, 2024 |
Jennifer Jarrett |
|
|
|
|
|
|
|
|
|
/s/
Neil Graham |
|
Director |
|
September 3, 2024 |
Neil Graham |
|
|
|
|
|
|
|
|
|
/s/
Someit Sidhu, MD |
|
Director |
|
September 3, 2024 |
Someit Sidhu, MD |
|
|
|
|
|
|
|
|
|
/s/
Parvinder Thiara |
|
Director |
|
September 3, 2024 |
Parvinder Thiara |
|
|
|
|
SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE
OF THE REGISTRANT
Pursuant
to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of Zura Bio Limited
has signed this registration statement on the 3rd day of September, 2024.
|
|
|
|
Zura Bio
Limited |
|
|
|
|
By: |
/s/
Robert Lisicki |
|
|
Name: Robert Lisicki |
|
|
Title: Chief Executive
Officer |
Exhibit 1.2
ZURA BIO LIMITED
US$125,000,000
CLASS A ORDINARY SHARES
SALES AGREEMENT
September 3, 2024
LEERINK PARTNERS LLC
1301 Avenue of the Americas, 5th Floor
New York, New York 10019
Ladies and Gentlemen:
Zura Bio Limited, a Cayman Islands exempted company
(the “Company”), confirms its agreement (this “Agreement”) with Leerink Partners LLC
(the “Agent”), as follows:
1. Issuance
and Sale of Shares. The Company agrees that, from time to time during the term of this Agreement, on the terms and subject to the
conditions set forth herein, it may issue and sell through the Agent of Class A ordinary shares, US$0.0001 par value per share, of
the Company (the “Ordinary Shares”), subject to the limitations set forth in Section 5(c) (the “Placement
Shares”). Notwithstanding anything to the contrary contained herein, the parties hereto agree that compliance with the limitation
set forth in this Section 1 on the aggregate gross sales price of Placement Shares that may be issued and sold under this Agreement
from time to time shall be the sole responsibility of the Company, and that the Agent shall have no obligation in connection with such
compliance. The issuance and sale of Placement Shares through the Agent will be effected pursuant to the Registration Statement (as defined
below) filed by the Company with the Securities and Exchange Commission (the “Commission”) on September 3,
2024 and to be declared effective by the Commission, although nothing in this Agreement shall be construed as requiring the Company to
issue any Placement Shares.
The Company has prepared and will file, in accordance
with the provisions of the Securities Act of 1933, as amended, and the rules and regulations thereunder (collectively, the “Securities
Act”), with the Commission a registration statement on Form S-3, including (a) a base prospectus, relating to
certain securities, including the Ordinary Shares, to be issued from time to time by the Company, and which incorporates by reference
documents that the Company has filed or will file in accordance with the provisions of the Securities Exchange Act of 1934, as amended,
and the rules and regulations thereunder (collectively, the “Exchange Act”), and (b) a prospectus
supplement specifically relating to the Placement Shares to be issued from time to time pursuant to this Agreement (the “Prospectus
Supplement”) to the base prospectus included as part of such registration statement. The Company will furnish to the Agent,
for use by the Agent, copies of the base prospectus included as part of such registration statement at the time it becomes effective,
as supplemented by the Prospectus Supplement. Except where the context otherwise requires, such registration statement, including all
documents filed as part thereof or incorporated by reference therein, and including any information contained in a Prospectus (as defined
below) subsequently filed with the Commission pursuant to Rule 424(b) under the Securities Act or deemed to be a part of such
registration statement pursuant to Rule 430B or Rule 462(b) under the Securities Act, is herein called the “Registration
Statement.” The base prospectus, including all documents incorporated therein by reference, included in the Registration
Statement, as it may be supplemented by the Prospectus Supplement, in the form in which such prospectus and/or Prospectus Supplement have
most recently been filed by the Company with the Commission pursuant to Rule 424(b) under the Securities Act, together with
any “issuer free writing prospectus” (as used herein, as defined in Rule 433 under the Securities Act (“Rule 433”)),
relating to the Placement Shares that (i) is required to be filed with the Commission by the Company or (ii) is exempt from
filing pursuant to Rule 433(d)(5)(i), in each case, in the form filed or required to be filed with the Commission or, if not required
to be filed, in the form retained in the Company’s records pursuant to Rule 433(g), is herein called the “Prospectus.”
Any reference herein to the Registration Statement,
the Prospectus Supplement, the Prospectus or any issuer free writing prospectus shall be deemed to refer to and include the documents,
if any, that are or are deemed to be incorporated by reference therein (the “Incorporated Documents”), including,
unless the context otherwise requires, the documents, if any, filed as exhibits to such Incorporated Documents. Any reference herein to
the terms “amend,” “amendment” or “supplement” with respect to the Registration Statement, the Prospectus
Supplement, the Prospectus or any issuer free writing prospectus shall be deemed to refer to and include the filing of any document under
the Exchange Act on or after the most-recent effective date of the Registration Statement, or the respective dates of the Prospectus Supplement,
Prospectus or such issuer free writing prospectus, as the case may be, and incorporated therein by reference. For purposes of this Agreement,
all references to the Registration Statement, the Prospectus or any amendment or supplement thereto shall be deemed to include the most
recent copy filed with the Commission pursuant to its Electronic Data Gathering Analysis and Retrieval System or, if applicable, the Interactive
Data Electronic Application system when used by the Commission (collectively, “EDGAR”).
2. Placements.
Each time that the Company wishes to issue and sell any Placement Shares through the Agent hereunder (each, a “Placement”),
it will notify the Agent by email notice (or other method mutually agreed to in writing by the parties) (each such notice, a “Placement
Notice”) containing the parameters in accordance with which it desires such Placement Shares to be sold, which at a minimum
shall include the maximum number or amount of Placement Shares to be sold, the time period during which sales are requested to be made,
any limitation on the number or amount of Placement Shares that may be sold in any one Trading Day (as defined in Section 3) and
any minimum price below which sales may not be made, a form of which containing such minimum sales parameters is attached hereto as Schedule
1. The Placement Notice must originate from one of the individuals authorized to act on behalf of the Company and set forth on
Schedule 2 (with a copy to each of the other individuals from the Company listed on such Schedule 2), and
shall be addressed to each of the recipients from the Agent set forth on Schedule 2, as such Schedule 2 may
be updated by either party from time to time by sending a written notice containing a revised Schedule 2 to the other party
in the manner provided in Section 12 (including by email correspondence to all of the individuals of the Company set forth on Schedule
2, if receipt of such correspondence is actually acknowledged by any of the individuals to whom the notice is sent, other than
via auto-reply). The Placement Notice shall be effective upon receipt by the Agent unless and until (i) in accordance with the notice
requirements set forth in Section 4, the Agent declines to accept the terms contained therein for any reason, in its sole discretion,
within two Trading Days of the date the Agent receives the Placement Notice, (ii) in accordance with the notice requirements set
forth in Section 4, the Agent suspends sales under the Placement Notice for any reason in its sole discretion, (iii) the entire
amount of the Placement Shares has been sold pursuant to this Agreement, (iv) in accordance with the notice requirements set forth
in Section 4, the Company suspends sales under or terminates the Placement Notice for any reason in its sole discretion, (v) the
Company issues a subsequent Placement Notice and explicitly indicates that its parameters supersede those contained in the earlier dated
Placement Notice or (vi) this Agreement has been terminated pursuant to the provisions of Section 11. The amount of any discount,
commission or other compensation to be paid by the Company to the Agent in connection with the sale of the Placement Shares effected through
the Agent shall be calculated in accordance with the terms set forth in Schedule 3. It is expressly acknowledged and agreed
that neither the Company nor the Agent will have any obligation whatsoever with respect to a Placement or any Placement Shares unless
and until the Company delivers a Placement Notice to the Agent and the Agent does not decline such Placement Notice pursuant to the terms
set forth above, and then only upon the terms specified therein and herein. In the event of a conflict between the terms of this Agreement
and the terms of a Placement Notice, the terms of the Placement Notice will control with respect to the matters covered thereby.
3. Sale
of Placement Shares by the Agent. On the basis of the representations and warranties herein contained and subject to the terms and
conditions herein set forth, including Section 5(c), upon the Agent’s acceptance of the terms of a Placement Notice as provided
in Section 2, and unless the sale of the Placement Shares described therein has been declined, suspended or otherwise terminated
in accordance with the terms of this Agreement, the Agent, for the period specified in the Placement Notice, will use its commercially
reasonable efforts consistent with its normal trading and sales practices and applicable state and federal laws, rules and regulations
and the rules of the Nasdaq Capital Market (“Nasdaq”) to sell such Placement Shares up to the number or
amount specified in, and otherwise in accordance with the terms of, such Placement Notice. The Agent will provide written confirmation
to the Company (including by email correspondence to each of the individuals of the Company set forth on Schedule 2, if
receipt of such correspondence is actually acknowledged by any of the individuals to whom the notice is sent, other than via auto-reply)
no later than the opening of the Trading Day (as defined below) immediately following the Trading Day on which it has made sales of Placement
Shares hereunder setting forth the number or amount of Placement Shares sold on such Trading Day, the volume-weighted average price of
the Placement Shares sold and the Net Proceeds (as defined below) payable to the Company. Unless otherwise specified by the Company in
a Placement Notice, the Agent may sell Placement Shares by any method permitted by law deemed to be an “at the market offering”
as defined in Rule 415(a)(4) of the Securities Act, including sales made directly on or through Nasdaq or on or through any
other existing trading market for the Ordinary Shares. If expressly authorized by the Company (including in a Placement Notice), the Agent
may also sell Placement Shares in negotiated transactions. Notwithstanding the provisions of Section 6(rr), except as may be otherwise
agreed by the Company and the Agent, the Agent shall not purchase Placement Shares on a principal basis pursuant to this Agreement unless
the Company and the Agent enter into a separate written agreement setting forth the terms of such sale. The Company acknowledges and agrees
that (i) there can be no assurance that the Agent will be successful in selling Placement Shares, (ii) the Agent will incur
no liability or obligation to the Company or any other person or entity if it does not sell Placement Shares for any reason other than
a failure by the Agent to use its commercially reasonable efforts consistent with its normal trading and sales practices and applicable
state and federal laws, rules and regulations and the rules of Nasdaq to sell such Placement Shares as required under this Agreement
and (iii) the Agent shall be under no obligation to purchase Placement Shares on a principal basis pursuant to this Agreement unless
the Company and the Agent enter into a separate written agreement setting forth the terms of such sale. For the purposes hereof, “Trading
Day” means any day on which the Ordinary Shares are purchased and sold on Nasdaq.
4. Suspension
of Sales.
(a) The
Company or the Agent may, upon notice to the other party in writing (including by email correspondence to each of the individuals of the
other party set forth on Schedule 2, if receipt of such correspondence is actually acknowledged by any of the individuals
to whom the notice is sent, other than via auto-reply) or by telephone (confirmed immediately by email correspondence to each of the individuals
of the other party set forth on Schedule 2), suspend any sale of Placement Shares; provided, however, that
such suspension shall not affect or impair either party’s obligations with respect to any Placement Shares sold hereunder prior
to the receipt of such notice. The Agent may, in its sole discretion, upon notice to the Company, suspend any sale of Placement Shares
if the Company files any amendment or supplement with the Commission pursuant to Section 7(a)(iv). While a suspension pursuant to
this Section 4(a) is in effect, any obligation under Section 7(m), 7(n), 7(o), 7(p) and 7(q) with respect to
the delivery of certificates, opinions or comfort letters to the Agent, shall be waived. Each of the parties agrees that no such notice
under this Section 4 shall be effective against the other party unless notice is sent by one of the individuals named on Schedule
2 hereto to the other party in writing (including by email correspondence to each of the individuals of the other party set forth
on Schedule 2, if receipt of such correspondence is actually acknowledged by any of the individuals to whom the notice is
sent, other than via auto-reply).
(b) Notwithstanding
any other provision of this Agreement, during any period in which the Company is in possession of material non-public information, the
Company and the Agent agree that (i) no sale of Placement Shares will take place, (ii) the Company shall not request the sale
of any Placement Shares and shall cancel any effective Placement Notices instructing the Agent to make any sales and (iii) the Agent
shall not be obligated to sell or offer to sell any Placement Shares.
5. Settlement
and Delivery of the Placement Shares.
(a) Settlement
of Placement Shares. Unless otherwise specified in the applicable Placement Notice, settlement for sales of Placement Shares will
occur on the first Trading Day (or such earlier day as is industry practice or as is required for regular-way trading) following the date
on which such sales are made (each, a “Settlement Date”). The amount of proceeds to be delivered to the Company
on a Settlement Date against receipt of the Placement Shares sold (the “Net Proceeds”) will be equal to the
aggregate gross sales price received by the Agent at which such Placement Shares were sold, after deduction of (i) the Agent’s
commission, discount or other compensation for such sales payable by the Company pursuant to Section 2 hereof, (ii) any other
amounts due and payable by the Company to the Agent hereunder pursuant to Section 7(g) hereof and (iii) any transaction
fees imposed by any governmental or self-regulatory organization in respect of such sales.
(b) Delivery
of Placement Shares. On or before each Settlement Date, the Company will issue the Placement Shares being sold on such date and will,
or will cause its transfer agent to, electronically transfer such Placement Shares by crediting the Agent’s or its designee’s
account (provided the Agent shall have given the Company written notice of such designee prior to the Settlement Date) at The Depository
Trust Company through its Deposit and Withdrawal at Custodian System (“DWAC”) or by such other means of delivery
as may be mutually agreed upon by the parties hereto, which in all cases shall be duly authorized, freely tradeable, transferable, registered
Ordinary Shares in good deliverable form. On each Settlement Date, the Agent will deliver the related Net Proceeds in same day funds to
an account designated by the Company on or prior to the Settlement Date. The Agent shall be responsible for providing DWAC instructions
or other instructions for delivery by other means with regard to the transfer of the Placement Shares being sold. In addition to and in
no way limiting the rights and obligations set forth in Section 9(a) hereto, the Company agrees that if the Company, defaults
in its obligation to deliver duly authorized, freely tradeable, transferable, registered Placement Shares in good deliverable form by
2:30 P.M., New York City time, on a Settlement Date (other than as a result of a failure by the Agent to provide instructions for delivery),
the Company will (i) take all necessary action to cause the full amount of any Net Proceeds that were delivered to the Company’s
account with respect to such settlement, together with any costs incurred by the Agent and/or its clearing firm in connection with recovering
such Net Proceeds, to be immediately returned to the Agent or its clearing firm no later than 5:00 P.M., New York City time, on such
Settlement Date, by wire transfer of immediately available funds to an account designated by the Agent or its clearing firm, (ii) indemnify
and hold the Agent and its clearing firm harmless against any loss, claim, damage, or expense (including reasonable legal fees and expenses),
as incurred, arising out of or in connection with such default by the Company or its transfer agent (if applicable) and (iii) pay
to the Agent (without duplication) any commission, discount or other compensation to which it would otherwise have been entitled absent
such default.
(c) Limitations
on Offering Size. Under no circumstances shall the Company cause or request the offer or sale of any Placement Shares if, after giving
effect to the sale of such Placement Shares, the aggregate number or gross sales proceeds of Placement Shares sold pursuant to this Agreement
would exceed the lesser of: (i) the number or dollar amount of Ordinary Shares registered pursuant to, and available for offer and
sale under, the Registration Statement pursuant to which the offering of Placement Shares is being made, (ii) the number of authorized
but unissued Ordinary Shares of the Company (less Ordinary Shares issuable upon exercise, conversion or exchange of any outstanding securities
of the Company or otherwise reserved from the Company’s authorized share capital), (iii) the number or dollar amount of Ordinary
Shares permitted to be offered and sold by the Company under Form S-3 (including General Instruction I.B.6. thereof, if such instruction
is applicable), (iv) the number or dollar amount of Ordinary Shares that the Company’s board of directors or a duly authorized
committee thereof is authorized to issue and sell from time to time, and notified to the Agent in writing, or (v) the dollar amount
of Ordinary Shares for which the Company has filed the Prospectus Supplement. Under no circumstances shall the Company cause or request
the offer or sale of any Placement Shares pursuant to this Agreement at a price lower than the minimum price authorized from time to time
by the Company’s board of directors or a duly authorized committee thereof, and notified to the Agent in writing. Notwithstanding
anything to the contrary contained herein, the parties hereto acknowledge and agree that compliance with the limitations set forth in
this Section 5(c) on the number or dollar amount of Placement Shares that may be issued and sold under this Agreement from time
to time shall be the sole responsibility of the Company, and that the Agent shall have no obligation in connection with such compliance.
6. Representations
and Warranties of the Company. The Company represents and warrants to, and agrees with, the Agent that as of the date of this Agreement,
and as of (i) each Representation Date (as defined in Section 7(m)), (ii) each date on which a Placement Notice is given,
(iii) the date and time of each sale of any Placement Shares pursuant to this Agreement and (iv) each Settlement Date (each
such time or date referred to in clauses (i) through (iv), an “Applicable Time”):
(a) The
Company is eligible for and the transactions contemplated by this Agreement meet the requirements for and comply with the conditions for
the use of Form S-3 (including General Instructions I.A and I.B.1.) under the Securities Act. The Registration Statement and
any Rule 462(b) Registration Statement will have been filed with the Commission and will have been declared effective by the
Commission under the Securities Act prior to the issuance of any Placement Notices by the Company. The Company has complied to the Commission’s
satisfaction with all requests of the Commission for additional or supplemental information. At the time the Registration Statement becomes
effective, the Company will meet the then-applicable requirements for use of Form S-3 (including General Instructions I.A and I.B.1.)
under the Securities Act. The Registration Statement, when filed, will meet, and the offering and sale of Placement Shares as contemplated
hereby will comply with, the requirements of Rule 415(a)(1)(x) under the Securities Act. The Agent will be named as the agent
engaged by the Company in the section entitled “Plan of Distribution” in the Prospectus Supplement. The Company has not received,
and has no notice from the Commission of, any notice pursuant to Rule 401(g)(1) under the Securities Act objecting to the use
of the shelf registration statement form. No stop order of the Commission preventing or suspending the use of the base prospectus, the
Prospectus Supplement or the Prospectus, or the effectiveness of the Registration Statement, has been issued, and no proceedings for such
purpose are pending before or, to the knowledge of the Company, threatened by the Commission. At the time of the initial filing of the
Registration Statement, the Company will have paid the required Commission filing fees relating to the securities covered by the Registration
Statement, including the Shares that may be sold pursuant to this Agreement, in accordance with Rule 457(o) under the Securities
Act. Copies of the Registration Statement, the Prospectus, any such amendments or supplements to any of the foregoing and all Incorporated
Documents that were or will be filed with the Commission on or prior to the date of this Agreement have been delivered, or are available
through EDGAR, to the Agent and its counsel.
(b) Each
of the Registration Statement and any post-effective amendment thereto, at the time it became or becomes effective, at each deemed effective
date with respect to the Agent pursuant to Rule 430B(f)(2) under the Securities Act and as of each Applicable Time, complied,
complies and/or will comply in all material respects with the requirements of the Securities Act and did not, does not and will not contain
any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
therein not misleading, except that the representations and warranties set forth in this sentence do not apply to Agent’s Information
(as defined below). The Prospectus and any amendment or supplement thereto, when so filed with the Commission under Rule 424(b) under
the Securities Act, complied, complies and as of each Applicable Time will comply in all material respects with the requirements of the
Securities Act, and each Prospectus Supplement, Prospectus or issuer free writing prospectus (or any amendments or supplements to any
of the foregoing) furnished to the Agent for use in connection with the offering of the Placement Shares was identical to the electronically
transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by Regulation S-T. Neither the
Prospectus nor any amendment or supplement thereto, as of its date and as of each Applicable Time, included, includes or will include
an untrue statement of a material fact or omitted, omits or will omit to state a material fact necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not misleading, except that the representations and warranties
set forth in this sentence do not apply to Agent’s Information. Each Incorporated Document heretofore filed, when it was filed (or,
if any amendment with respect to any such document was filed, when such amendment was filed), conformed in all material respects with
the requirements of the Exchange Act and were filed on a timely basis with the Commission, and any further Incorporated Documents so filed
and incorporated after the date of this Agreement will be filed on a timely basis and, when so filed, will conform in all material respects
with the requirements of the Exchange Act; no such Incorporated Document when it was filed (or, if an amendment with respect to any such
document was filed, when such amendment was filed), contained an untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they
were made, not misleading; and no such Incorporated Document, when it is filed, will contain an untrue statement of a material fact or
will omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading.
(c) (i) At
the time of filing the Registration Statement and (ii) at the time of the execution of this Agreement (with such date being used
as the determination date for purposes of this clause (ii)), the Company was not and is not an “ineligible issuer” (as defined
in Rule 405), without taking account of any determination by the Commission pursuant to Rule 405 that it is not necessary that
the Company be considered an ineligible issuer.
(d) The
Company is, and since March 10, 2021 has been, an “emerging growth company,” as defined in Section 2(a) of
the Securities Act (an “Emerging Growth Company”).
(e) Each
issuer free writing prospectus, as of its issue date and as of each Applicable Time, did not, does not and will not include any information
that conflicted, conflicts or will conflict with the information contained in the Registration Statement or the Prospectus, including
any Incorporated Document deemed to be a part thereof that has not been superseded or modified. Each issuer free writing prospectus that
the Company has filed, or is required to file, pursuant to Rule 433 or that was prepared by or on behalf of or used by the Company
complies or will comply in all material respects with the requirements of the Securities Act.
(f) The
Company has not distributed and, prior to the later to occur of each Settlement Date and completion of the Agent’s distribution
of the Placement Shares under this Agreement, will not distribute any offering material in connection with the offering and sale of the
Placement Shares other than the Registration Statement, the Prospectus or any Permitted Free Writing Prospectus (as defined below).
(g) The
interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement and the
Prospectus fairly presents the information called for in all material respects and has been prepared in accordance in all material respects
with the Commission’s rules and guidelines applicable thereto.
(h) The
Company is subject to and in compliance in all material respects with the reporting requirements of Section 13 or Section 15(d) of
the Exchange Act. The Ordinary Shares are registered pursuant to Section 12(b) of the Exchange Act and is listed on Nasdaq,
and the Company has taken no action designed to, or reasonably likely to have the effect of, terminating the registration of the Ordinary
Shares under the Exchange Act or delisting the Ordinary Shares from Nasdaq, nor has the Company received any notification that the Commission
or Nasdaq is contemplating terminating such registration or listing. The Company is in compliance with the current listing standards of
Nasdaq. The Company has filed a Notification of Listing of Additional Shares with Nasdaq with respect to the Placement Shares.
(i) No
person (as such term is defined in Rule 1-02 of Regulation S-X promulgated under the Securities Act) has the right to act as an underwriter
or as a financial advisor to the Company in connection with the offer and sale of the Placement Shares hereunder, whether as a result
of the filing or effectiveness of the Registration Statement or the sale of the Placement Shares as contemplated hereby or otherwise.
Except for the Agent, there is no broker, finder or other party that is entitled to receive from the Company or any of its Subsidiaries
(as defined below) any brokerage or finder’s fee or other fee or commission as a result of any transactions contemplated by this
Agreement.
(j) The
Company has been duly incorporated and is validly existing as an exempted company in good standing under the laws of the Cayman Islands,
with full corporate power and authority to acquire, own, lease and operate its properties, and to conduct its business as described in
the Registration Statement and the Prospectus and to enter into and perform its obligations under this Agreement. The Company is duly
qualified to transact business as a foreign corporation and is conducting business consistently with the laws of good standing in the
State of New York and under the laws of each other jurisdiction that requires such qualification, whether by reason of the ownership or
leasing of property or the conduct of business, except to the extent that the failure to be so qualified or in good standing would not
reasonably be expected, individually or in the aggregate, to have a material adverse effect on the condition (financial or otherwise),
earnings, results of operations, business, properties, operations, assets, liabilities or prospects of the Company and its Subsidiaries,
taken as a whole, whether or not arising from transactions in the ordinary course of business (a “Material Adverse Effect”).
(k) Each
of the Company’s “subsidiaries” (for purposes of this Agreement, as defined in Rule 405 under the Securities Act)
(each, a “Subsidiary” and collectively, the “Subsidiaries”) has been duly organized
and is validly existing in good standing (where such concept exists) under the laws of the jurisdiction of its organization and has full
power and authority to acquire, own, lease and operate its properties, and to conduct its business as, described in the Registration Statement
and the Prospectus. Each Subsidiary is duly qualified to transact business and is in good standing (where such concept exists) under the
laws of each jurisdiction that requires such qualification, whether by reason of the ownership or leasing of property or the conduct of
business, except to the extent that the failure to be so qualified or in good standing would not reasonably be expected, individually
or in the aggregate, to have a Material Adverse Effect. All of the issued and outstanding share capital or other equity or ownership interests
of each Subsidiary has been duly authorized and validly issued, is fully paid and non-assessable, has been issued in compliance with federal
state and securities laws and is owned by the Company, directly or through other wholly-owned Subsidiaries, free and clear of any security
interest, mortgage, pledge, lien, encumbrance or adverse claim. The Company does not own or control, directly or indirectly, any corporation,
association or other entity, other than the Subsidiaries listed on Exhibit 21 to the Company’s most recent Annual Report on
Form 10-K filed with the Commission. No Subsidiary is prohibited or restricted, directly or indirectly, from paying dividends to
the Company, from making any other distribution with respect to such Subsidiary’s equity securities, from repaying to the Company
or any other Subsidiary any amounts that may from time to time become due under any loans or advances to such Subsidiary from the Company
or from transferring any property or assets to the Company or to any other Subsidiary.
(l) The
Company has the authorized and outstanding capitalization as set forth in the Company’s annual report on Form 10-K for the
most recent fiscal year or, if later, the Company’s quarterly report on Form 10-Q for the most recent fiscal quarter, as of
the dates referred to therein (subject, in each case, to the issuance of Placement Shares under this Agreement, the issuance of Ordinary
Shares upon exercise of share options and warrants disclosed as outstanding as of the date hereof in the Registration Statement and the
Prospectus and the grant of options under existing share option plans described in the Registration Statement and the Prospectus). The
Ordinary Shares conform in all material respects to the description thereof contained in the Registration Statement and the Prospectus,
including under the heading “Description of Shares.” All of the issued and outstanding share capital or other equity or ownership
interest of the Company (including the Ordinary Shares) has been duly authorized and validly issued and is fully paid and non-assessable,
has been issued in compliance with all federal, state and local securities laws and is free and clear of any security interest, mortgage,
pledge, encumbrance or adverse claim. None of the outstanding Ordinary Shares of share capital of the Company were issued in violation
of any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase securities of the Company. There
are no authorized or outstanding options, warrants, preemptive rights, rights of first refusal or other rights to purchase or subscribe
for, or equity or debt securities convertible into or exchangeable or exercisable for, any shares of the Company or any of its Subsidiaries
other than those described in the Registration Statement, the Prospectus, or any Incorporated Document. The descriptions of the Company’s
equity incentive plan, share option plans and other plans or arrangements described in the Prospectus and in effect as of the date hereof
(collectively, the “Stock Plans”) and the options or other rights granted thereunder, set forth in the Registration
Statement and the Prospectus accurately and fairly present the information required to be shown with respect to such Stock Plans and the
options or other rights granted thereunder.
(m) The
Placement Shares have been duly authorized for issuance and sale pursuant to this Agreement and, when issued and delivered by the Company
against payment therefor pursuant to this Agreement, will be validly issued, fully paid and non-assessable and will conform in all material
respects to the description thereof contained in the Prospectus. The issuance and sale of the Placement Shares as contemplated hereby
shall not be subject to any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase the Placement
Shares. When issued and delivered by the Company against payment therefor pursuant to this Agreement, the purchasers of the Placement
Shares issued and sold hereunder will acquire good, marketable and valid title to such Placement Shares, free and clear of all pledges,
security interests, charges, claims or encumbrances. The issuance and sale of the Placement Shares as contemplated hereby will not cause
any holder of any shares, securities convertible into or exchangeable or exercisable for share capital or options, warrants or other rights
to purchase shares or any other securities of the Company to have any right to acquire any preferred shares of the Company. There are
no restrictions upon the voting or transfer of the Ordinary Shares under the Company’s second amended and restated memorandum and
articles of association or any agreement or other instrument to which the Company is a party or otherwise filed as an exhibit to the Registration
Statement.
(n) There
is no statute, regulation, contract, agreement or other document required to be described in the Registration Statement, Prospectus or
in any Incorporated Document, or to be filed as an exhibit to the Registration Statement or any Incorporated Document which is not described
or filed as required. The statements set forth or incorporated by reference in the Prospectus, insofar as they purport to constitute summaries
of the terms of the statutes, regulations, contracts, agreements or other documents described and filed, constitute accurate summaries
of the terms thereof in all material respects. The statements set forth or incorporated by reference in the Prospectus under the headings
“Risk Factors” and “Description of Shares,” insofar as such statements summarize legal matters, agreements, documents
or proceedings discussed therein, are accurate and fair summaries of such legal matters, agreements, documents or proceedings. The statements
in the Prospectus under the heading “Material U.S. Federal Income Tax Consequences to U.S. Holders,” insofar as such statements
purport to summarize provisions of U.S. federal income tax laws, fairly present, to the extent required by the Securities Act and the
rules and regulations thereunder, in all material respects, such provisions. Neither the Company nor any of its Subsidiaries has
sent or received any communication regarding termination of, or intent not to renew or render performance under, any of the contracts
or agreements referred to or described in the Prospectus or any free writing prospectus, or referred to or described in, or filed as an
exhibit to, the Registration Statement, or any Incorporated Document, and no such termination or non-renewal has been threatened by the
Company or any of its Subsidiaries or, to the Company’s knowledge, any other party to any such contract or agreement, which threat
of termination or non-renewal has not been rescinded as of the date hereof.
(o) This
Agreement has been duly and validly authorized, executed and delivered by the Company and constitutes a valid and legally binding obligation
of the Company, enforceable against the Company in accordance with its terms, except as enforceability, including rights of indemnification,
may be limited by bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and other similar laws relating to or affecting
creditors’ rights generally and by general principles of equity. This Agreement conforms in all material respects to the descriptions
thereof in the Registration Statement and the Prospectus.
(p) The
Company is not and, after giving effect to the offering and sale of the Placement Shares and the application of the proceeds thereof as
described in the Prospectus, will not be an “investment company” as defined in the Investment Company Act of 1940, as amended.
(q) No
consent, approval, license, permit, qualification, authorization or other order or decree of, or registration or filing with, any court
or other governmental, taxing or regulatory authority or agency, is required for the Company’s execution, delivery and performance
of this Agreement or consummation of the transactions contemplated hereby or by the Registration Statement and the Prospectus (including
the issuance and sale of the Placement Shares hereunder), except such as have been already obtained or made or as may be required under
the Securities Act, applicable state securities or Blue Sky laws, applicable rules of Nasdaq, or Rule 5110 of the Financial
Industry Regulatory Authority, Inc. (“FINRA”).
(r) Neither
the execution and delivery by the Company of, nor the performance of the Company of its obligations under, this Agreement will conflict
with, result in a breach or violation of, or result in the creation or imposition of any charge or encumbrance upon any property or assets
of the Company or any of its Subsidiaries pursuant to: (i) the memorandum and articles of association (as amended from time to time),
certificate or articles of incorporation, charter, bylaws, limited liability company agreement, certificate or agreement of limited or
general partnership or other similar organizational documents, as the case may be, of such entity, (ii) the terms of any indenture,
contract, license, lease, mortgage, deed of trust, note agreement, agreement or other instrument, obligation, condition, covenant or instrument
to which it is a party or bound or to which its property or assets is subject or (iii) any statute, law, rule, regulation, judgment,
order or decree applicable to the Company or any of its Subsidiaries of any court, regulatory body, administrative agency, governmental
body, arbitrator or other authority having jurisdiction over the Company, any of its Subsidiaries or any of their respective properties
or assets, as applicable, except, in the case of clauses (ii) and (iii) above, for any such conflict, breach, violation or default
that would not, individually or in the aggregate, have a Material Adverse Effect.
(s) Subsequent
to the respective dates as of which information is given in the Registration Statement and the Prospectus: (i) there has been no
material adverse change, or any development that could reasonably be expected to result in a material adverse change, in the condition
(financial or otherwise), earnings, results of operations, business, properties, operations, assets, liabilities or prospects of the Company
and its Subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course of business; (ii) neither
the Company nor its Subsidiaries has (A) incurred any material liability or obligation, indirect, direct or contingent, including
without limitation any losses or interference with its business from fire, explosion, flood, earthquakes, accident or other calamity,
whether or not covered by insurance, or from any strike, labor dispute or court or governmental action, order or decree, that are material,
individually or in the aggregate, to the Company and its Subsidiaries, considered as one entity, (B) entered into any material transactions
not in the ordinary course of business or (C) issued or granted any shares of the Company’s share capital or securities convertible
into or exchangeable or exercisable for or that represent the right to receive shares of the Company’s share capital other than
under the Stock Plans; and (iii) there has not been any material decrease in the share capital or any material increase in any short-term
or long-term indebtedness of the Company or any of its Subsidiaries and there has been no dividend or distribution of any kind declared,
paid or made by the Company or, except for dividends paid to the Company or another Subsidiary, by any Subsidiary on any class of shares,
or any repurchase or redemption by the Company or any of its Subsidiaries of any class of shares.
(t) There
are no persons (as such term is defined in Rule 1-02 of Regulation S-X promulgated under the Securities Act) with registration or
other similar rights to have any equity or debt securities of the Company registered for sale under the Registration Statement or included
in the offering contemplated by this Agreement, except for such rights as have been duly waived in a writing previously furnished to the
Agent.
(u) The
financial statements included or incorporated by reference in the Registration Statement and the Prospectus, together with the related
notes and schedules, present fairly, in all material respects, the consolidated financial position of the Company and the Subsidiaries
as of the dates indicated and the consolidated results of operations, cash flows and changes in shareholders’ equity of the Company
and the Subsidiaries for the periods specified and have been prepared in compliance with the requirements of the Securities Act and Exchange
Act and in conformity with United States generally accepted accounting principles (“GAAP”) applied on a consistent
basis during the periods involved, except as may be set forth in the related notes included therein. To the extent applicable, any pro
forma financial statements, information or data included or incorporated by reference in the Registration Statement and the Prospectus
comply with the requirements of Regulation S-X of the Securities Act, including, without limitation, Article 11 thereof, fairly present
the information set forth herein, and the assumptions used in the preparation of such pro forma financial statements and data are reasonable,
the pro forma adjustments used therein are appropriate to give effect to the circumstances referred to therein and the pro forma adjustments
have been properly applied to the historical amounts in the compilation of those statements and data. The other financial data set forth
or incorporated by reference in the Registration Statement and the Prospectus is accurately and fairly presented and prepared on a basis
consistent with the financial statements and books and records of the Company. There are no financial statements (historical or pro forma)
that are required to be included or incorporated by reference in the Registration Statement or the Prospectus that are not included or
incorporated by reference therein as required. The Company and the Subsidiaries do not have any material liabilities or obligations, direct
or contingent (including any off-balance sheet obligations or any “variable interest entities” as that term is used in Accounting
Standards Codification Paragraph 810-10-25-20), not disclosed in the Registration Statement and the Prospectus. All disclosures contained
in the Registration Statement or the Prospectus that contain “non-GAAP financial measures” (as such term is defined by the
rules and regulations of the Commission) comply, in all material respects, with Regulation G under the Exchange Act and Item 10 of
Regulation S-K under the Securities Act, to the extent applicable. The statistical, industry-related and market-related data included
or incorporated by reference in the Registration Statement and the Prospectus were obtained or derived from sources which the Company
reasonably and in good faith believes are reliable and accurate, such data agree with the sources from which they are derived, and the
Company has obtained the written consent to the use of such data from such sources to the extent required. To the Company’s knowledge,
no person who has been suspended or barred from being associated with a registered public accounting firm, or who has failed to comply
with any sanction pursuant to Rule 5300 promulgated by the Public Company Accounting Oversight Board (“PCAOB”),
has participated in or otherwise aided the preparation of, or audited, the financial statements, supporting schedules or other financial
data filed with the Commission as a part of the Registration Statement and the Prospectus.
(v) There
are no actions, suits, claims, investigations or proceedings pending or, to the Company’s knowledge, threatened to which the Company
or any of the Subsidiaries is or would be a party, or of which any of the respective properties or assets of the Company and the Subsidiaries
is or would be subject, at law or in equity, before any court or arbitral body or by or before any federal, state, local or foreign governmental
or regulatory commission, board, body, authority or agency, that (i) are required to be described in the Registration Statement or
the Prospectus and are not so described, (ii) could reasonably be expected to have a material adverse effect on the ability of the
Company to perform its obligations under this Agreement or on the consummation of any of the transactions contemplated hereby or (iii) could
reasonably be expected to have a Material Adverse Effect. The aggregate of all pending legal or governmental proceedings to which the
Company or any of its Subsidiaries is a party or of which any of their respective properties or assets is the subject which are not described
in the Prospectus, including ordinary routine litigation incidental to the Company’s business, could not reasonably be expected
to (A) result in a Material Adverse Effect or (B) have a material adverse effect on the ability of the Company to perform its
obligations under this Agreement or the consummation of any of the transactions contemplated hereby.
(w) The
Company owns or leases all such real properties as are necessary to the conduct of its operations as presently conducted in all material
respects.
(x) Neither
the Company nor any Subsidiary is in violation or default of (i) any provision of its memorandum and articles of association (as
amended from time to time), certificate or articles of incorporation, charter, bylaws, limited liability company agreement, certificate
or agreement of limited or general partnership, or other similar organizational documents, as the case may be, of such entity, (ii) the
terms of any indenture, contract, lease, mortgage, deed of trust, note agreement, loan agreement or other agreement, obligation, condition,
covenant or instrument to which it is a party or bound or to which its property or assets is subject, or (iii) any statute, law,
rule, regulation, judgment, order or decree of any court, regulatory body, administrative agency, governmental body, arbitrator or other
authority having jurisdiction over the Company, any of its Subsidiaries or any of their respective properties or assets, as applicable,
except, in the case of clauses (ii) and (iii) above, for any such default or violation that would not, individually or in the
aggregate, have a Material Adverse Effect.
(y) WithumSmith+Brown,
PC (“Withum”), the Company’s independent registered public accounting firm, whose report on the consolidated
financial statements of the Company is filed with the Commission as part of the Company’s most recent annual report on Form 10-K
filed with the Commission and incorporated by reference in the Registration Statement and the Prospectus, is (i) an independent registered
public accounting firm as required by the Securities Act, the Exchange Act and the rules of the PCAOB, (ii) in compliance with
the applicable requirements relating to the qualification of accountants under Rule 2-01 of Regulation S-X under the Securities Act
and (iii) a registered public accounting firm as defined by the PCAOB whose registration has not been suspended or revoked and who
has not requested such registration to be withdrawn. Withum has not been engaged by the Company to perform any “prohibited activities”
or provided to the Company any “non-audit services” (as defined in Section 10A of the Exchange Act).
(z) There
are no transfer taxes or other similar fees or charges under federal law, the laws of any state, any foreign law, or any political subdivision
thereof, required to be paid in connection with the execution and delivery of this Agreement or the issuance by the Company or sale by
the Company of the Placement Shares.
(aa) Each
of the Company and its Subsidiaries has filed all U.S., federal, state, local and foreign tax returns that are required to have been filed
pursuant to applicable law except insofar as the failure to file such returns would not, individually or in the aggregate, reasonably
be expected to result in a Material Adverse Effect, and paid all taxes due pursuant to such returns or pursuant to any assessment received
by the Company and its Subsidiaries, except for such taxes, if any, as are being contested in good faith and as to which adequate reserves
have been provided and except for such taxes or assessments the nonpayment of which would not, individually or in the aggregate, reasonably
be expected to result in a Material Adverse Effect. The Company does not have any knowledge of any tax deficiencies that have been asserted
against the Company that would, individually or in the aggregate, not reasonably be expected to result in a Material Adverse Effect. All
material taxes which the Company and its Subsidiaries are required by law to withhold or to collect for payment have been duly withheld
and collected and have been paid to the appropriate governmental authority or agency or have been accrued, reserved against and entered
on the books of the Company and its Subsidiaries.
(bb) No
labor dispute with the employees of the Company or any of its Subsidiaries exists or, to the Company’s knowledge, is threatened
or imminent, and the Company is not aware of any existing, threatened or imminent labor disturbance by the employees of any of its or
any of its Subsidiaries’ principal suppliers, manufacturers, contractors or customers, in each case that would have a Material Adverse
Effect. None of the employees of the Company or any of its Subsidiaries is represented by a union and, to the knowledge of the Company,
no union organizing activities are taking place. Neither the Company nor any of its Subsidiaries has violated (or received notice of any
violation of) any federal, state or local law or foreign law relating to the discrimination in hiring, promotion or pay of employees,
nor any applicable wage or hour laws, or the rules and regulations thereunder, or analogous foreign laws and regulations, which would,
individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect.
(cc) Each
of the Company and its Subsidiaries are insured by recognized and reputable institutions with policies in such amounts and with such deductibles
and covering such risks as are generally deemed adequate and customary for their businesses including, but not limited to, policies covering
real and personal property owned or leased by the Company and its Subsidiaries against theft, damage, destruction, acts of vandalism and
earthquakes and policies covering the Company and its Subsidiaries for clinical trial liability claims. The Company has no reason to believe
that it or any of its Subsidiaries will not be able (i) to renew its existing insurance coverage as and when such policies expire
or (ii) to obtain comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now
conducted and at a cost that could not reasonably be expected to have a Material Adverse Effect. Neither the Company nor any of its Subsidiaries
has been denied any material insurance coverage which it has sought or for which it has applied.
(dd) Except
as set forth in the Registration Statement or the Prospectus, the Company and each of its Subsidiaries has good and marketable title in
fee simple to all real property owned by them and good and marketable title to all personal property owned by them that is material to
their business (except with respect to intellectual property, which is addressed exclusively in Section 6(nn) and Section 6(aaa)
below), in each case free and clear of all liens, encumbrances and defects except such as do not materially affect the value of such property
and do not interfere with the use made and proposed to be made of such property by the Company or any Subsidiary.
(ee) The
Company and its Subsidiaries possess and are operating in compliance with such valid and current material certificates, authorizations
or permits required by United States federal, state or foreign regulatory agencies or bodies to conduct their respective businesses as
currently conducted and as described in the Registration Statement and the Prospectus (collectively, “Permits”),
except where the failure to so possess would not reasonably be expected, individually or in the aggregate, to have a Material Adverse
Effect. Neither the Company nor any of its Subsidiaries is in violation of, or in default under, any of the Permits or has received any
written notice of proceedings relating to the revocation or modification of, or non-compliance with, any such certificate, authorization
or permit, which, individually or in the aggregate, if the subject of an unfavorable decision, ruling or finding, would reasonably be
expected to result in a Material Adverse Effect.
(ff) The
Company and its Subsidiaries, on a consolidated basis, make and keep books and records that are accurate in all material respects and
maintain a system of internal accounting controls designed, and which the company believes is sufficient, to provide reasonable assurance
that: (i) transactions are executed in accordance with management’s general or specific authorization; (ii) transactions
are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain accountability for assets;
(iii) access to assets is permitted only in accordance with management’s general or specific authorization; and (iv) the
recorded accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect
to any differences.
(gg) The
Company has established and maintains disclosure controls and procedures (as defined in Rules 13a-15 and 15d-15 under the Exchange
Act), which (i) are designed to ensure that material information relating to the Company, including its consolidated Subsidiaries,
is made known to the Company’s principal executive officer and its principal financial officer by others within those entities,
particularly during the periods in which the periodic reports required under the Exchange Act are being prepared; (ii) have been
evaluated by management of the Company for effectiveness as of the end of the Company’s most recent fiscal quarter; and (iii) are
effective in all material respects to perform the functions for which they were established. Since the end of the Company’s most
recent audited fiscal year, there has been no material weakness in the Company’s internal control over financial reporting (whether
or not remediated) and no change in the Company’s internal control over financial reporting, including any corrective actions with
regard to significant deficiencies or material weaknesses, that has materially affected, or is reasonably likely to materially affect,
the Company’s internal control over financial reporting. The Company is not aware of any change in its internal control over financial
reporting that has occurred during its most recent fiscal quarter that has materially affected, or is reasonably likely to materially
affect, the Company’s internal control over financial reporting.
(hh) Neither
the Company, nor any of its Subsidiaries, nor to the knowledge of the Company, any of its or their respective directors, officers or controlling
persons has taken, directly or indirectly, without giving effect to any actions taken by the Agent, (i) any action designed to or
that would reasonably be expected to cause or result in, under the Exchange Act or otherwise, stabilization or manipulation of the price
of any security of the Company to facilitate the sale or resale of the Placement Shares or (ii) any action designed to or that might
constitute or reasonably be expected to cause or result in a violation of Regulation M under the Exchange Act.
a. (ii) Except
as could not reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect: (i) neither the Company
nor any of its Subsidiaries is in violation of any applicable United States federal, state or local, or any foreign, statute, law, rule,
regulation, ordinance, code, policy or rule of common law or any judicial or administrative interpretation thereof, including any
judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the environment (including,
without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation,
laws and regulations relating to the emissions, discharges, release or threatened release of chemicals, pollutants, contaminants, wastes,
toxic substances, hazardous substances, petroleum or petroleum products (collectively, “Hazardous Materials”)
or otherwise related to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous
Materials (collectively, “Environmental Laws”); (ii) the Company and its Subsidiaries have all material
permits, authorizations and approvals required under any applicable Environmental Laws and are in compliance with their requirements;
(iii) there are no pending or, to the Company’s knowledge, threatened administrative, regulatory or judicial actions, suits,
demands, demand letters, claims, liens, notices of noncompliance or violation, investigation or proceedings relating to any Environmental
Law against the Company or any of its Subsidiaries, or any investigation with respect to which the Company or any of its Subsidiaries
has received written notice or any written notice by any person or entity alleging potential liability for investigatory costs, cleanup
costs, governmental responses costs, natural resources damages, property damages, personal injuries, attorneys’ fees or penalties
arising out of, based on or resulting from the presence, or release into the environment, of any Hazardous Materials at any location owned,
leased or operated by the Company or any of its Subsidiaries, now or in the past; and (iv) to the Company’s knowledge, there
are no events or circumstances that might reasonably be expected to form the basis of an order for clean-up or remediation, or an action,
suit, investigation or proceeding by any private party or governmental body or agency, against or affecting the Company or any of its
Subsidiaries relating to Hazardous Materials or any Environmental Laws.
(ii) Except
as would not reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect: (i) the Company and any
“employee benefit plan” (as defined under the Employee Retirement Income Security Act of 1974, as amended, and the regulations
and published interpretations thereunder (collectively, “ERISA”)) established or maintained by the Company,
or any member of any group of organizations described in Sections 414(b), (c), (m) or (o) of the Internal Revenue Code of 1986,
as amended, and the regulations and published interpretations thereunder (the “Code”) of which the Company is
a member (“ERISA Affiliates”) are in compliance in all material respects with ERISA; (ii)no “reportable
event” (as defined under ERISA) has occurred or is reasonably expected to occur with respect to any “employee benefit plan”
established or maintained by the Company, or any of its ERISA Affiliates; (iii) no “employee benefit plan” established
or maintained by the Company or any of its ERISA Affiliates, if such “employee benefit plan” were terminated, would have any
“amount of unfunded benefit liabilities” (as defined under ERISA); (iv) neither the Company nor any of its ERISA Affiliates
has incurred or reasonably expects to incur any liability under (x) Title IV of ERISA with respect to termination of, or withdrawal
from, any “employee benefit plan” or (y) Sections 412, 4971, 4975 or 4980B of the Code; and (v) each “employee
benefit plan” established or maintained by the Company or any of its ERISA Affiliates that is intended to be qualified under Section 401(a) of
the Code is so qualified and nothing has occurred, whether by action or failure to act, which would reasonably be expected to cause the
loss of such qualification.
(jj) The
Company is in compliance in all material respects with, and there is and has been no failure on the part of the Company and, to the Company’s
knowledge, any of the Company’s directors or officers, in their capacities as such, to comply with, any provision of the Sarbanes-Oxley
Act of 2002 and all rules and regulations promulgated thereunder or implementing the provisions thereof (the “Sarbanes-Oxley
Act”) and the rules and regulations promulgated in connection therewith, including Section 402 relating to loans,
in each case to the extent to which the Company is required to comply.
(kk) Neither
the Company, any of its Subsidiaries, nor, to the knowledge of the Company, any of their respective directors, officers, agents, employees
or affiliates, has taken or will take any action, directly or indirectly, that (i) would result in a violation by such persons of
any applicable anti-corruption laws, including the Foreign Corrupt Practices Act of 1977, as amended, and the rules and regulations
thereunder (the “FCPA”) including, without limitation, making use of the mails or any means or instrumentality
of interstate commerce corruptly in furtherance of an offer, payment, promise to pay or authorization of the payment of any money, or
other property, gift, promise to give, or authorization of the giving of anything of value to any “foreign official” (as such
term is defined in the FCPA) or any foreign political party or official thereof or any candidate for foreign political office or otherwise
took any action (or failed to fully disclose any action) in contravention of the FCPA; and the Company, its Subsidiaries and each of their
respective affiliates have conducted their businesses in compliance with the FCPA and have instituted and maintain, and will continue
to maintain, policies and procedures designed to ensure, and which are reasonably expected to continue to ensure, continued compliance
therewith, (ii) is in furtherance of an offer, payment, promise to pay, or authorization or approval of the unlawful payment or giving
of money, property, gifts or anything else of value, directly or indirectly, to any “government official” (including any officer
or employee of a government or government-owned or controlled entity or of a public international organization, or any person acting in
an official capacity for or on behalf of any of the foregoing, or any political party or party official or candidate for political office)
to influence official action or secure an improper advantage; and the Company, each of its Subsidiaries and, to the Company’s knowledge,
each of their respective affiliates have conducted their businesses in compliance with applicable anti-corruption laws, or (iii)
could result in a violation or a sanction for violation by such persons of the Foreign Corrupt Practices Act of 1977 or the U.K. Bribery
Act 2010, each as may be amended, or similar law of any other relevant jurisdiction, or the rules or regulations thereunder;
and the Company and its Subsidiaries have instituted and maintain policies and procedures designed to ensure compliance therewith. No
part of the proceeds of the offering will be used, directly or indirectly, in violation of the Foreign Corrupt Practices Act of 1977 or
the U.K. Bribery Act 2010, each as may be amended, or similar law of any other relevant jurisdiction, or the rules or regulations
thereunder.
(ll) The
operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicable financial recordkeeping
and reporting requirements and the anti-money laundering statutes and the rules and regulations thereunder and any related or similar
rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Money Laundering
Laws”) and no action, suit, investigation or proceeding by or before any court or governmental agency, authority or body
or any arbitrator involving the Company or any of its Subsidiaries with respect to the Money Laundering Laws is pending or, to the best
of the Company’s knowledge, threatened.
(mm) Neither
the Company nor any of its Subsidiaries nor, to the knowledge of the Company, any director, officer, agent, employee or affiliate of the
Company or any of its Subsidiaries (i) is, or is controlled or 50% or more owned in the aggregate by or is acting on behalf of, one
or more individuals or entities that are currently the subject of any sanctions administered or enforced by the United States (including
any administered or enforced by the Office of Foreign Assets Control of the U.S. Department of the Treasury, the U.S. Department of State
or the Bureau of Industry and Security of the U.S. Department of Commerce), the United Nations Security Council, the European Union, a
member state of the European Union (including sanctions administered or enforced by His Majesty’s Treasury of the United Kingdom)
or other relevant sanctions authority (collectively, “Sanctions” and such persons, “Sanctioned Persons”
and each such person, a “Sanctioned Person”), (ii) is located, organized or resident in a country or territory
that is, or whose government is, the subject of Sanctions that broadly prohibit dealings with that country or territory (collectively,
“Sanctioned Countries” and each, a “Sanctioned Country”) or (iii) will, directly
or indirectly, use the proceeds of this offering, or lend, contribute or otherwise make available such proceeds to any Subsidiary, joint
venture partner or other individual or entity in any manner that would result in a violation of any Sanctions by any individual or entity
(including any individual or entity participating in the offering, whether as underwriter, advisor, investor or otherwise). Neither the
Company nor any of its Subsidiaries has engaged in any dealings or transactions with or for the benefit of a Sanctioned Person, or with
or in a Sanctioned Country, in the preceding 3 years, nor does the Company or any of its Subsidiaries have any plans to engage in dealings
or transactions with or for the benefit of a Sanctioned Person, or with or in a Sanctioned Country, in violation of Sanctions.
(nn) The
Company and its Subsidiaries own or possess the right to use all inventions, patent applications, patents, trademarks, trade names, service
names, domain names, copyrights, trade secrets, know-how and other intellectual property as are (i) necessary or material for the
conduct of their respective businesses as currently conducted or as currently proposed to be conducted and as described in the Registration
Statement and the Prospectus and (ii) necessary or material for the commercialization of the products described in the Registration
Statement and the Prospectus as being under development (collectively, “Intellectual Property”). There is no
pending or, to the Company’s knowledge, threatened (i) action, suit, proceeding, or claim by others challenging the rights
of the Company or any of its Subsidiaries in or to any such Intellectual Property that, if decided adversely to the Company or such Subsidiary
would, individually or in the aggregate, have a Material Adverse Effect, and the Company is unaware of any facts which would form a reasonable
basis for any such claim; (ii) action, suit, proceeding, or claim by others that the Company or any of its Subsidiaries infringes,
misappropriates, or otherwise violates any Intellectual Property of others that, if decided adversely to the Company or such Subsidiary
would, individually or in the aggregate, have a Material Adverse Effect, and the Company is unaware of any facts which would form a reasonable
basis for any such claim; or (iii) action, suit, proceeding, or claim by others challenging the validity, scope, or enforceability
of any such Intellectual Property owned or licensed by the Company or its Subsidiaries that, if decided adversely to the Company or such
Subsidiary would, individually or in the aggregate, have a Material Adverse Effect, and the Company is unaware of any facts which
would form a reasonable basis for any such claim. To the Company’s knowledge, the operation of the business of the Company and its
Subsidiaries as now conducted, and as described in the Prospectus, and in connection with the development and commercialization of the
products described in the Prospectus does not infringe, misappropriate, conflict with or otherwise violate any claim of any patent or
published patent application of any other person or entity. There is no prior art of which the Company or any of its Subsidiaries is aware
that may render any patent owned or licensed by the Company or its Subsidiaries invalid or any patent application owned or licensed by
the Company or its Subsidiaries unpatentable which has not been disclosed to the applicable government patent office once in substantive
prosecution. The Company’s granted or issued patents have been duly maintained since in-licensing by the Company or its Subsidiaries
and are accordingly in full force and effect, and none of the patents have been adjudged invalid or unenforceable in whole or in part
since in-licensing by the Company or its Subsidiaries. The Company knows of no infringement, misappropriation or violation by others of
any Intellectual Property owned or licensed by the Company or its Subsidiaries which would reasonably be expected to have a Material Adverse
Effect. Neither the Company nor any of its Subsidiaries is a party to or bound by any options, licenses or agreements with respect to
the Intellectual Property of any other person or entity that are required to be set forth in the Prospectus and that are not described
therein in all material respects. The Company and its Subsidiaries have taken all reasonable steps necessary to secure their interests
in the Intellectual Property of the Company and its Subsidiaries from their employees and contractors and to protect the confidentiality
of all of their confidential information and trade secrets. To the Company’s knowledge, none of the technology or intellectual property
used by the Company and its Subsidiaries in its business has been obtained or is being used by the Company or its Subsidiaries in violation
of any contractual obligation binding on the Company or its Subsidiaries, or, to the Company’s knowledge, any of its officers, directors
or employees or otherwise in violation of the rights of any persons. No third party has been granted by the Company or its Subsidiaries
rights to the Intellectual Property of the Company (other than the Company's and its Subsidiaries’ license agreements with Pfizer
and Eli Lilly, and non-exclusive licenses granted in the ordinary course of business) or its Subsidiaries, including any rights that,
if exercised, could enable such party to develop products competitive to those of the Company as described in the Registration Statement
and the Prospectus. All Intellectual Property owned or exclusively licensed by the Company or its Subsidiaries are free and clear of all
liens, encumbrances, defects or other restrictions (other than pursuant to the Company’s and its Subsidiaries' license agreements
with Pfizer and Eli Lilly and non-exclusive licenses granted in the ordinary course of business), except those that would not reasonably
be expected, individually or in the aggregate, to have a Material Adverse Effect. The Company and its Subsidiaries are not subject to
any judgment, order, writ, injunction or decree of any court or any federal, state, local, foreign or other governmental department, commission,
board, bureau, agency or instrumentality, domestic or foreign, or any arbitrator, nor has it entered into or is it a party to any agreement
made in settlement of any pending or threatened litigation, which materially restricts or impairs their use of any Intellectual Property.
(oo) The
Company and each of its Subsidiaries (i) are and have at all times been in compliance with all laws, statutes, rules, regulations
or guidance applicable to the Company and its Subsidiaries and the ownership, testing, development, manufacture, packaging, processing,
use, distribution, marketing, advertising, labeling, promotion, sale, offer for sale, storage, import, export or disposal of any pharmaceuticals
or biohazardous substances, materials or any other products developed, manufactured or distributed by the Company (including, without
limitation, from the United States Food and Drug Administration (“FDA”), European Medicines Agency (“EMA”)
and any local or other governmental or regulatory authority performing functions similar to those performed by the FDA or EMA) (collectively,
“Applicable Laws”), except as could not, individually or in the aggregate, reasonably be expected to result
in a Material Adverse Effect, (ii) have not received any notice of adverse finding, warning letter, untitled letter or other correspondence
or notice from the FDA or any other federal, state or foreign governmental authority having authority over the Company, any of its Subsidiaries
or their activities alleging or asserting material noncompliance with any Applicable Laws or any licenses, certificates, approvals, clearances,
authorizations, permits and supplements or amendments thereto required by any such Applicable Laws (collectively, the “Governmental
Permits”), (iii) have made all filings with, the appropriate local, or other governmental or regulatory agencies or
bodies that are necessary for the ownership or lease of their respective properties or the conduct of their respective businesses as described
in the Registration Statement and the Prospectus, except where any failures to possess or make the same would not, singularly or in the
aggregate, have a Material Adverse Effect, (iv) possess all material Governmental Permits necessary to conduct their respective businesses
as described in the Registration Statement and the Prospectus, and such Governmental Permits are valid and in full force and effect and
are not in violation of any term of any such Governmental Permits, (v) have filed, obtained, maintained or submitted all material
reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required by any Applicable
Laws or Governmental Permits and that all such reports, documents, forms, notices, applications, records, claims, submissions and supplements
or amendments were complete and correct in all material respects on the date filed (or were corrected or supplemented by a subsequent
submission), and (vi) are not a party to any corporate integrity agreements, monitoring agreements, consent decrees, settlement orders
or similar agreements with or imposed by any governmental authority. All Governmental Permits are valid and in full force and effect,
except where the validity or failure to be in full force and effect would not, singularly or in the aggregate, have a Material Adverse
Effect. Neither the Company nor any Subsidiary has received notification of any revocation, modification, suspension, termination or invalidation
(or proceedings related thereto) of any such Governmental Permit and the Company has no reason to believe that any such Governmental Permit
will not be renewed. Neither the Company, any of its Subsidiaries nor, to the Company’s knowledge, any of their respective directors,
officers, employees or agents has been convicted of any crime under any Applicable Laws or has been the subject of an FDA debarment proceeding.
Neither the Company nor any of its Subsidiaries has been nor is now subject to the FDA’s Application Integrity Policy. To the Company’s
knowledge, neither the Company, any of its Subsidiaries nor any of its directors, officers, employees or agents has made, or caused the
making of, any false statements on, or material omissions from, any other records or documentation prepared or maintained to comply with
the requirements of the FDA or any other governmental authority.
(pp) There
is no legal or governmental proceeding to which the Company or any of its Subsidiaries is a party or of which any property or assets of
the Company or any of its Subsidiaries is the subject, including any proceeding before the FDA, the EMA or any foreign, local, national
or other governmental agency with jurisdiction over the types of products being developed by the Company that is required to be described
in the Registration Statement or the Prospectus and is not described therein, or which, singularly or in the aggregate, if determined
adversely to the Company or any of its Subsidiaries, could reasonably be expected to have a Material Adverse Effect; and no such proceedings
are threatened or contemplated by governmental or regulatory authorities or threatened by others. The Company and its Subsidiaries (i) have
not received notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any
governmental authority or third party alleging that any product operation or activity is in violation of any Applicable Laws or Governmental
Permits and have no knowledge that any such governmental authority or third party is considering any such claim, litigation, arbitration,
action, suit, investigation or proceeding and (ii) have not received notice that any governmental authority has taken, is taking
or intends to take action to limit, suspend, modify or revoke any Governmental Permits and the Company has no knowledge that any such
governmental authority is considering such action.
(qq) The
non-clinical studies and clinical trials conducted or being conducted by or on behalf of the Company or any of its Subsidiaries or in
which any of their respective product candidates have participated and, to the Company’s knowledge, the non-clinical studies and
clinical trials directed or sponsored by the Company’s collaborators (collectively, the “Studies”) that
are described in, or the results of which are referred to in, the Registration Statement and the Prospectus, if any, were and, if still
pending, are being conducted with reasonable care and in all material respects in accordance with the protocols, procedures and controls
pursuant to all Applicable Laws and Governmental Permits and with standard medical and scientific research procedures; each description
of the results of such Studies is accurate and complete in all material respects and fairly presents the data derived from such Studies,
and the Company and its Subsidiaries have no knowledge of any other non-clinical studies or clinical trials the results of which are inconsistent
with, or otherwise call into question, the results described or referred to in the Registration Statement and the Prospectus; the Company
and its Subsidiaries have made all such filings and obtained all such approvals as may be required by the EMA, the FDA or any committee
thereof or from any other United States or foreign government agency with jurisdiction over the types of products being developed by the
Company; neither the Company nor any of its Subsidiaries has received any notice of, or correspondence from, any governmental authority
requiring the termination, suspension or modification of any Study; and the Company and its Subsidiaries have each operated and currently
are in compliance in all material respects with all applicable rules, regulations and policies of all governmental authorities. There
have been no material serious adverse events resulting from any Study. To the Company’s knowledge, the manufacturing facilities
and operations of its suppliers are operated in compliance in all material respects with all Applicable Laws and Governmental Permits.
(rr) The
Company acknowledges and agrees that the Agent has informed the Company that the Agent may, to the extent permitted under the Securities
Act and the Exchange Act, purchase and sell Ordinary Shares for its own account while this Agreement is in effect; provided, that
(i) no such purchase or sales shall take place while a Placement Notice is in effect (except to the extent the Agent may engage in
sales of Placement Shares purchased or deemed purchased from the Company as a “riskless principal” or in a similar capacity)
and (ii) the Company shall not be deemed to have authorized or consented to any such purchases or sales by the Agent, except as may
be otherwise agreed by the Company and the Agent.
(ss) The
Company is not a party to any agreement with an agent or underwriter for any other “at the market” or continuous equity transaction.
(tt) The
Company is not required to register as a “broker” or “dealer” in accordance with the provisions of the Exchange
Act and does not, directly or indirectly through one or more intermediaries, control or have any other association with (within the meaning
of Article I of the By-laws of FINRA) any member firm of FINRA. No relationship, direct or indirect, exists between or among the
Company, on the one hand, and the directors, officers or shareholders of the Company, on the other hand, which is required by the rules of
FINRA to be described in the Registration Statement and the Prospectus, which is not so described. All of the information (including,
but not limited to, information regarding affiliations, security ownership and trading activity) provided to the Agent or its counsel
by the Company, its officers and directors and the holders of any securities (debt or equity) or warrants, options or rights to acquire
any securities of the Company in connection with the filing to be made and other supplemental information to be provided to FINRA pursuant
to FINRA Rule 5110 in connection with the transactions contemplated by this Agreement is true, complete and correct.
(uu) As
of the close of trading on Nasdaq on August 29, 2024, the aggregate market value of the outstanding voting and non-voting common
equity (as defined in Rule 405) of the Company held by persons other than affiliates of the Company (pursuant to Rule 144 of
the Securities Act, those that directly, or indirectly through one or more intermediaries, control, or are controlled by, or are under
common control with, the Company) (the “Non-Affiliate Shares”), was approximately $200.0 million (calculated
by multiplying (x) the price at which the common equity of the Company was last sold on Nasdaq on August 29, 2024 by (y) the
number of Non-Affiliate Shares outstanding on August 29, 2024). The Company is not a shell company (as defined in Rule 405)
and has not been a shell company for at least 12 calendar months previously.
(vv) Neither
the issuance, sale and delivery of the Placement Shares nor the application of the proceeds thereof by the Company as described in the
Registration Statement and the Prospectus will violate Regulation T, U or X of the Board of Governors of the Federal Reserve System or
any other regulation of such Board of Governors.
(ww) Neither
the Company nor, to the Company’s knowledge, any of its affiliates (within the meaning of Rule 144 under the Securities Act)
has, prior to the date hereof, made any offer or sale of any securities which could be “integrated” (within the meaning of
the Securities Act) with the offer and sale of the Placement Shares hereunder.
(xx) Each
financial or operational projection or other “forward-looking statement” (as defined by Section 27A of the Securities
Act or Section 21E of the Exchange Act) contained in the Registration Statement or the Prospectus (i) was so included by the
Company in good faith and with reasonable basis after due consideration by the Company of the underlying assumptions, estimates and other
applicable facts and circumstances and (ii) as required, is accompanied by meaningful cautionary statements identifying those factors
that could cause actual results to differ materially from those in such forward-looking statement.
(yy) There
are no relationships, direct or indirect, or related party transactions involving the Company or any of its Subsidiaries or any other
person (including any director, officer, shareholder, customer or supplier of the Company or any of its Subsidiaries) required to be described
in the Registration Statement or the Prospectus that have not been described as required. There are no material outstanding loans, advances
(except normal advances for business expenses in the ordinary course of business) or guarantees of indebtedness by the Company or any
of its Subsidiaries to or for the benefit of any of the officers or directors of the Company or any of its Subsidiaries, or any of the
family members of any of such persons.
(zz) The
Company is not in or subject to a bankruptcy or insolvency proceeding in any jurisdiction.
(aaa) The
Company has duly and properly filed or caused to be filed with the U.S. Patent and Trademark Office (the “PTO”)
and applicable foreign and international patent and trademark authorities having similar requirements all patents, trademarks, copyrights
and applications relating to the same owned by the Company and its Subsidiaries (the “Company Patent and Trademark Applications”).
To the knowledge of the Company, the Company has complied with the PTO’s duty of candor and disclosure for the Company Patent and
Trademark Applications and has made no material misrepresentation in the Company Patent and Trademark Applications. To the Company’s
knowledge, patent applications filed by the Company disclose patentable subject matter. The Company has not been notified of any inventorship
challenges nor has any interference been declared or provoked nor is any material fact known by the Company that would preclude the issuance
of patents with respect to the Company Patent and Trademark Applications or would render such patents, if issued, invalid or unenforceable.
Except as would not have a Material Adverse Effect, neither the Company nor any of its Subsidiaries has breached and is currently in breach
of any provision of any license, contract or other agreement governing the use by the Company or its Subsidiaries of Intellectual Property
owned by third parties (collectively, the “Licenses”) and no third party has alleged any such breach and the
Company is unaware of any facts that would form a reasonable basis for such a claim. To the Company’s knowledge, no other party
to the Licenses has breached or is currently in breach of any provision of the Licenses. Each of the Licenses is in full force and effect
and constitutes a valid and binding agreement between the parties thereto, enforceable in accordance with its terms, and there has not
occurred any breach or default under any such Licenses or any event that, with the giving of notice or lapse of time, would constitute
a breach or default thereunder. Except as would not have a Material Adverse Effect, neither the Company nor any of its Subsidiaries has
been and is currently involved in any disputes regarding the Licenses. To the Company’s knowledge, all patents licensed to the Company
pursuant to the Licenses are valid, enforceable and being duly maintained. To the Company’s knowledge, all patent applications licensed
to the Company pursuant to the Licenses are being duly prosecuted.
(bbb) The Company and its Subsidiaries’ information technology assets and equipment, computers,
systems, networks, hardware, software, websites, applications, data (including the data of their respective customers, employees,
suppliers, vendors and any third party data maintained by or on behalf of them), and databases (collectively, “IT
Systems”) are adequate in all material respects for, and operate and perform in all material respects as required in
connection with the operation of the business of the Company and its Subsidiaries as currently conducted. Except as would not
reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect, to the Company’s knowledge, there
has been no security breach or attack or other compromise of or relating to any of the Company’s and its Subsidiaries’
IT Systems. The Company and its Subsidiaries are presently in compliance with all applicable laws or statutes and all judgments,
orders, rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and
contractual obligations relating to the privacy and security of IT Systems and data (including all personal, personally
identifiable, sensitive, confidential or regulated data (“Personal Data”)) and to the protection of such
IT Systems and Personal Data from unauthorized use, access, misappropriation or modification, except as could not, individually or
in the aggregate, reasonably be expected to result in a Material Adverse Effect. Neither the Company nor its Subsidiaries have
received any written notice of any claims, investigations, or alleged violations of law with respect to Personal Data.
(ccc) The
statistical and market related data included in the Registration Statement and the Prospectus are based on or derived from sources that
the Company believes to be reliable and accurate, and such data agree in all material respects with the sources from which they are derived.
(ddd) The
choice of laws of the State of New York as the governing law of this Agreement is a valid choice of law under the laws of the Cayman Islands
that will be honored by the courts of the Cayman Islands. The Company has the power to submit to the non-exclusive personal jurisdiction
of the State of New York, and the Company has the power to designate, appoint and authorize an authorized agent for service of process
in any action arising out of or relating to this Agreement or the Placement Shares in such courts in the State of New York, and service
of process effected on such authorized agent will be effective to confer valid personal jurisdiction over the Company.
(iii) Any
final judgment for a fixed sum of money rendered by a court having jurisdiction under its own domestic laws in respect of any suit, action
or proceeding against the Company based upon this Agreement and the Placement Shares would be recognized and enforced against the Company
by the courts of the Cayman Islands without re-examining the merits of the case under the common law doctrine of obligation; provided
that (i) adequate service of process has been effected and the defendant has had a reasonable opportunity to be heard, (ii) such
judgments or the enforcement thereof are not contrary to the law, public policy, security or sovereignty of the Cayman Islands, are given
by a foreign court of competent jurisdiction, are final and conclusive, and are not in respect of any tax, fine or other penalty, (iii) such
judgments were not obtained by fraudulent means and do not conflict with any other valid judgment in the same matter between the same
parties, and (iv) an action between the same parties in the same matter is not pending in any court of the Cayman Islands at the
time the lawsuit is instituted in a foreign court; it is not necessary that this Agreement, the Prospectus or any other document be filed
or recorded with any court or other authority in the Cayman Islands.
Any certificate signed by
any officer of the Company and delivered to the Agent or its counsel in connection with the offering of the Placement Shares shall be
deemed a representation and warranty by the Company, as to matters covered thereby, to the Agent.
7. Covenants
of the Company. The Company covenants and agrees with the Agent that:
(a) Registration
Statement Amendments. After the date of this Agreement and during any period in which the Prospectus relating to any Placement Shares
is required to be delivered by the Agent under the Securities Act (including in circumstances where such requirement may be satisfied
pursuant to Rule 172 under the Securities Act or a similar rule); (i) the Company will notify the Agent promptly of the time
when any subsequent amendment to the Registration Statement, other than Incorporated Documents, has been filed with the Commission and/or
has become effective or any subsequent supplement to the Prospectus, other than Incorporated Documents, has been filed and of any request
by the Commission for any amendment or supplement to the Registration Statement or Prospectus or for additional information (in each case,
insofar as it relates to the transactions contemplated hereby); (ii) the Company will prepare and file with the Commission, promptly
upon the Agent’s reasonable request, any amendments or supplements to the Registration Statement or Prospectus that, in the Agent’s
reasonable opinion, may be necessary or advisable in connection with the distribution of the Placement Shares by the Agent (provided,
however, that the failure of the Agent to make such request shall not relieve the Company of any obligation or liability hereunder, or
affect the Agent’s right to rely on the representations and warranties made by the Company in this Agreement and provided, further,
that the only remedy the Agent shall have with respect to the failure by the Company to make such filing (but without limiting the Agent’s
rights under Section 9 hereof) will be to cease making sales under this Agreement until such amendment or supplement is filed); (iii) the
Company will not file any amendment or supplement to the Registration Statement or Prospectus, other than Incorporated Documents, relating
to the offering of the Placement Shares unless a copy thereof has been submitted to the Agent within a reasonable period of time before
the filing and the Agent has not reasonably objected thereto (provided, however, that the failure of the Agent to make such objection
shall not relieve the Company of any obligation or liability hereunder, or affect the Agent’s right to rely on the representations
and warranties made by the Company in this Agreement and provided, further, that the only remedy the Agent shall have with respect to
the Company’s making such filing notwithstanding the Agent’s objection (but without limiting the Agent’s rights under
Section 9 hereof) will be to cease making sales under this Agreement) and the Company will furnish to the Agent at the time of filing
thereof a copy of any Incorporated Document, except for those documents available via EDGAR; and (iv) the Company will cause each
amendment or supplement to the Prospectus, other than Incorporated Documents, to be filed with the Commission as required pursuant to
the applicable paragraph of Rule 424(b) of the Securities Act and, in the case of any Incorporated Document, to be filed with
the Commission as required pursuant to the Exchange Act, within the time period prescribed (the determination to file any amendment or
supplement with the Commission under this Section 7(a), upon notice to the Agent, based on the Company’s reasonable opinion
or reasonable objections, shall be made exclusively by the Company; provided that the Agent may, in its sole discretion, suspend sales
of Placement Shares under Section 4).
(b) Notice
of Commission Stop Orders. The Company will advise the Agent, promptly after it receives notice or obtains knowledge thereof, of the
issuance or threatened issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement, of the
suspension of the qualification of the Placement Shares for offering or sale in any jurisdiction or of the initiation or threatening of
any proceeding for any such purpose; and it will promptly use its commercially reasonable efforts to prevent the issuance of any stop
order or to obtain its withdrawal if such a stop order should be issued. The Company will advise the Agent promptly after it receives
any request by the Commission for any amendments to the Registration Statement or any amendment or supplements to the Prospectus or for
additional information related to the offering of the Placement Shares or for additional information related to the Registration Statement
or the Prospectus.
(c) Delivery
of Prospectus; Subsequent Changes. During any period in which the Prospectus relating to the Placement Shares is required to be delivered
by the Agent under the Securities Act with respect to the offer and sale of the Placement Shares (including in circumstances where such
requirement may be satisfied pursuant to Rule 172 under the Securities Act or a similar rule), the Company will comply with all requirements
imposed upon it by the Securities Act, as from time to time in force, and will file on or before their respective due dates (taking into
account any extensions available under the Exchange Act) all reports and any definitive proxy or information statements required to be
filed by the Company with the Commission pursuant to Sections 13(a), 13(c), 14, 15(d) or any other provision of or under the Exchange
Act. If during such period any event occurs as a result of which the Prospectus as then amended or supplemented would include an untrue
statement of a material fact or omit to state a material fact necessary to make the statements therein, in the light of the circumstances
then existing, not misleading, or if during such period it is necessary to amend or supplement the Registration Statement or Prospectus
to comply with the Securities Act, the Company will promptly notify the Agent to suspend the offering of Placement Shares during such
period and the Company will promptly amend or supplement the Registration Statement or Prospectus (at the expense of the Company) so as
to correct such statement or omission or effect such compliance. If the Company has omitted any information from the Registration Statement
pursuant to Rule 430B under the Securities Act, it will use its best efforts to comply with the provisions thereof and make all requisite
filings with the Commission pursuant to said Rule 430B and to notify the Agent promptly of all such filings if not available on EDGAR.
(d) Listing
of Placement Shares. During any period in which the Prospectus relating to the Placement Shares is required to be delivered by the
Agent under the Securities Act with respect to the offer and sale of the Placement Shares (including in circumstances where such requirement
may be satisfied pursuant to Rule 172 under the Securities Act or a similar rule), the Company will use its commercially reasonable
efforts to cause the Placement Shares to be listed on Nasdaq. The Company will timely file with Nasdaq all material documents and notices
required by Nasdaq of companies that have or will issue securities that are traded on Nasdaq.
(e) Delivery
of Registration Statement and Prospectus. The Company will furnish to the Agent and its counsel (at the expense of the Company) copies
of the Registration Statement, the Prospectus (including all Incorporated Documents) and all amendments and supplements to the Registration
Statement or Prospectus that are filed with the Commission during any period in which the Prospectus relating to the Placement Shares
is required to be delivered under the Securities Act (including all Incorporated Documents filed with the Commission during such period),
in each case as soon as reasonably practicable and in such quantities as the Agent may from time to time reasonably request and, at the
Agent’s request, will also furnish copies of the Prospectus to each exchange or market on which sales of the Placement Shares may
be made; provided, however, that the Company shall not be required to furnish any document (other than the Prospectus) to
the Agent to the extent such document is available on EDGAR.
(f) Earnings
Statement. The Company will make generally available to its security holders and to the Agent as soon as practicable, but in any event
not later than 15 months after the end of the Company’s current fiscal quarter, an earnings statement covering a 12-month period
that satisfies the provisions of Section 11(a) of and Rule 158 under the Securities Act; provided that the Company will
be deemed to have furnished such statement to its security holders and the Agent to the extent such statement has been filed on EDGAR.
(g) Expenses.
The Company, whether or not the transactions contemplated hereunder are consummated or this Agreement is terminated in accordance with
the provisions of Section 11 hereunder, will pay all expenses incident to the performance of its obligations hereunder, including
expenses relating to (i) the preparation, printing and filing of the Registration Statement and each amendment and supplement thereto,
of the Prospectus and of each amendment and supplement thereto and of this Agreement and such other documents as may be required in connection
with the offering, purchase, sale, issuance or delivery of the Placement Shares, (ii) the preparation, issuance, sale and delivery
of the Placement Shares and any stamp or transfer taxes due or payable in connection therewith, (iii) the qualification of the Placement
Shares under securities laws in accordance with the provisions of Section 7(w) of this Agreement, including filing fees (provided,
however, that any fees or disbursements of counsel for the Agent in connection therewith shall be paid by the Agent except as set forth
in clauses (vii) and (viii) below), (iv) the printing and delivery to the Agent and its counsel of copies of the Prospectus
and any amendments or supplements thereto, and of this Agreement, (v) the fees and expenses incurred in connection with the listing
or qualification of the Placement Shares for trading on Nasdaq, (vi) the filing fees and expenses, if any, owed to the Commission
or FINRA and the fees and expenses of any transfer agent or registrar for the Shares, (vii) the reasonable and documented fees and
associated expenses of the Agent’s outside legal counsel for filings with the FINRA Corporate Financing Department in an amount
not to exceed US$10,000 (excluding FINRA filing fees referred to in clause (vi) above and in addition to the fees and disbursements
referred to in clause (viii) below), and (viii) the reasonable fees and disbursements of the Agent’s outside legal counsel
(A) in an amount not to exceed US$75,000 arising out of executing this Agreement and the Company’s delivery of the initial
certificate pursuant to Section 7(m), (B) in an amount not to exceed US$25,000 in connection with each Representation Date (as
defined below) involving the filing of a Form 10-K (including any Form 10-K/A containing amended financial information or a
material amendment to the previously filed Form 10-K) on which the company is required to provide a certificate pursuant to Section 7(m) (in
addition to the fees and associated expenses referred to in clause (vii) above) and (C) in an amount not to exceed US$15,000
in connection with each other Representation Date on which the Company is required to provide a certificate pursuant to Section 7(m) (in
addition to the fees and associated expenses referred to in clause (vii) above).
(h) Use
of Proceeds. The Company will use the Net Proceeds as described in the Prospectus in the section entitled “Use of Proceeds.”
(i) Notice
of Other Sales. Without the prior written consent of the Agent, the Company will not, directly or indirectly, offer to sell, sell,
contract to sell, grant any option to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares offered pursuant
to this Agreement) or securities convertible into or exchangeable or exercisable for Ordinary Shares, warrants or any rights to purchase
or acquire Ordinary Shares during the period beginning on the second Trading Day immediately prior to the date on which any Placement
Notice is delivered to Agent hereunder and ending on the first Trading Day immediately following the final Settlement Date with respect
to Placement Shares sold pursuant to such Placement Notice (or, if the Placement Notice has been terminated or suspended prior to the
sale of all Placement Shares covered by a Placement Notice, the date of such suspension or termination); and will not directly or indirectly
in any other “at the market offering” or continuous equity transaction offer to sell, sell, contract to sell, grant any option
to sell or otherwise dispose of any Ordinary Shares (other than the Placement Shares offered pursuant to this Agreement) or securities
convertible into or exchangeable or exercisable for Ordinary Shares, warrants or any rights to purchase or acquire, Ordinary Shares prior
to the termination of this Agreement; provided, however, that such restrictions will not be required in connection with
the Company’s issuance or sale of (i) Ordinary Shares, options to purchase Ordinary Shares, other securities under the Company’s
equity incentive plans, or Ordinary Shares issuable upon the exercise of options or vesting of other securities, pursuant to any employee
or director stock option or benefits plan, stock ownership plan or dividend reinvestment plan (but not Ordinary Shares subject to a waiver
to exceed plan limits in its dividend reinvestment plan) of the Company whether now in effect or hereafter implemented, (ii) Ordinary
Shares issuable upon conversion of securities or the exchange and/or exercise of warrants, options or other rights in effect or outstanding,
and disclosed in filings by the Company available on EDGAR or otherwise in writing to the Agent and (iii) Ordinary Shares or securities
convertible into or exchangeable for Ordinary Shares as consideration for mergers, acquisitions, joint ventures, collaborations, licensing
agreements, other business combinations or strategic alliances occurring after the date of this Agreement which are not issued for capital
raising purposes; (iv) warrants issued upon the surrender and cancellation of outstanding Ordinary Shares; and (v) modification
of any outstanding options, warrants of any rights to purchase or acquire Ordinary Shares. Notwithstanding the foregoing provisions, nothing
herein shall be construed to restrict the Company’s ability to (i) file, or require the Company to provide notice to the Agent
of the filing of, a registration statement, or amendment or supplement thereto, under the Securities Act or (ii) enter into and/or
consummate a committed underwritten equity offering with the Agent’s prior written consent, or otherwise prohibit the issuance of
its equity securities in a private placement transaction.
(j) Change
of Circumstances. The Company will, at any time during a fiscal quarter in which the Company intends to tender a Placement Notice
or sell Placement Shares, advise the Agent promptly after it shall have received notice or obtained knowledge of any information or fact
that would alter or affect in any material respect any opinion, certificate, letter or other document provided or required to be provided
to the Agent pursuant to this Agreement.
(k) Due
Diligence Cooperation. During the term of this Agreement, the Company will cooperate with any reasonable due diligence review conducted
by the Agent, its affiliates agents and counsel from time to time in connection with the transactions contemplated hereby, including providing
information and making available documents and senior corporate officers, during regular business hours and at the Company’s principal
offices, as the Agent may reasonably request.
(l) Required
Filings Relating to Placement of Placement Shares. The Company agrees that on or prior to such dates as the Securities Act shall require,
with respect to the Placement Shares, the Company will (i) file a prospectus supplement with the Commission under the applicable
paragraph of Rule 424(b) under the Securities Act, which prospectus supplement will set forth, within the relevant period, the
number or amount of Placement Shares sold through the Agent, the Net Proceeds to the Company and the compensation payable by the Company
to the Agent with respect to such Placement Shares, and (ii) deliver such number of copies of each such prospectus supplement to
each exchange or market on which such sales were effected as may be required by the rules or regulations of such exchange or market;
provided, that, unless a prospectus supplement containing such information is required to be filed under the Securities Act, the
requirement of this Section 7(l) may be satisfied by Company’s inclusion in the Company’s Form 10-K or Form 10-Q,
as applicable, of the number or amount of Placement Shares sold through the Agent, the Net Proceeds to the Company and the compensation
payable by the Company to the Agent with respect to such Placement Shares during the relevant period.
(m) Representation
Dates; Certificate. On or prior to the date on which the Company first delivers a Placement Notice pursuant to this agreement (the
“First Placement Notice Date”) and each time the Company:
(i) amends
or supplements the Registration Statement or the Prospectus (other than (x) a prospectus supplement filed in accordance with Section 7(l) of
this Agreement or (y) a prospectus supplement relating solely to an offering of securities other than the Placement Shares) by means
of a post-effective amendment, sticker or supplement but not by means of incorporation of document(s) by reference into the Registration
Statement or the Prospectus;
(ii) files
an annual report on Form 10-K under the Exchange Act (including any Form 10-K/A containing amended financial information or
a material amendment to the previously filed Form 10-K);
(iii) files
a quarterly report on Form 10-Q under the Exchange Act; or
(iv) files
a current report on Form 8-K containing amended financial information (other than an earnings release that is “furnished”
pursuant to Item 2.02 or Item 7.01 of Form 8-K) under the Exchange Act (each date of filing of one or more of the documents referred
to in clauses (i) through (iv) shall be a “Representation Date”),
the Company shall furnish the Agent (but in the
case of clause (iv) above only if the Agent reasonably determines that the information contained in such Form 8-K is material
at a time when a Placement Notice is pending or in effect and the Agent requests such certificate within three Business Days after the
filing of such Form 8-K with the Commission) with a certificate, in the form substantially similar to the form attached hereto as
Exhibit 7(m) (modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended
or supplemented), within three Trading Days of any Representation Date. The requirement to provide a certificate under this Section 7(m) shall
be waived for any Representation Date occurring at a time at which no Placement Notice is pending or in effect, or if a suspension is
in effect with respect to any Placement Notice, which waiver shall continue until the earlier to occur of (1) the date the Company
delivers a Placement Notice hereunder (which for such calendar quarter shall be considered a Representation Date) and (2) the next
occurring Representation Date. Notwithstanding the foregoing, if the Company subsequently decides to sell Placement Shares following a
Representation Date on which the Company relied on the waiver referred to in the previous sentence and did not provide the Agent with
a certificate under this Section 7(m), then before the Company delivers a Placement Notice or the Agent sells any Placement Shares
pursuant thereto, the Company shall provide the Agent with a certificate, in the form attached hereto as Exhibit 7(m),
dated the date of such Placement Notice. Within three Trading Days of each Representation Date, the Company shall have furnished to the
Agent such further information, certificates and documents as the Agent may reasonably request.
(n) Legal
Opinions. On or prior to the First Placement Notice Date and on any date which the Company is obligated to deliver a certificate pursuant
to Section 7(m) for which no suspension or waiver is applicable, the Company shall cause to be furnished to the Agent the written
opinion and negative assurance letter of each of (i) Cooley LLP, U.S. counsel to the Company (“U.S. Company Counsel”),
and (ii) Ogier (Cayman) LLP, Cayman Islands, counsel to the Company (“Cayman Company Counsel”) or such
other counsel reasonably satisfactory to the Agent, in form and substance reasonably satisfactory to the Agent and its counsel, dated
the date that the opinion and negative assurance letter are required to be delivered, modified, as necessary, to relate to the Registration
Statement and the Prospectus as then amended or supplemented; provided, however, that the Company shall be required to furnish
to the Agent no more than one opinion from U.S. Company Counsel and Cayman Company Counsel in connection with each annual report on Form 10-K;
and provided further that in lieu of such opinion and negative assurance letter for subsequent Representation Dates, Cayman Company
Counsel may furnish the Agent with a letter to the effect that the Agent may rely on a prior opinion or negative assurance letter delivered
by such Cayman Company Counsel under this Section 7(n) to the same extent as if it were dated the date of such letter (except
that statements in such prior opinion or negative assurance letter shall be deemed to relate to the Registration Statement and the Prospectus
as amended or supplemented at such Representation Date).
(o) Intellectual
Property Opinion. On or prior to the First Placement Notice Date and on any date which the Company is obligated to deliver a
certificate pursuant to Section 7(m) for which no waiver is applicable, the Company shall cause to be furnished to the
Agent the written opinion of counsel for the Company with respect to intellectual property matters, or such other intellectual
property counsel satisfactory to the Agent (“Intellectual Property Counsel”), in form and substance
satisfactory to the Agent and its counsel, dated the date that the opinion letter is required to be delivered, modified, as
necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented; provided, however, that in
lieu of such written opinion for subsequent Representation Dates, Intellectual Property Counsel may furnish the Agent with a
letter to the effect that the Agent may rely on a prior opinion letter delivered by such counsel under this
Section 7(o) to the same extent as if it were dated the date of such opinion letter (except that statements in such prior
opinion letter shall be deemed to relate to the Registration Statement and the Prospectus as amended or supplemented at such
Representation Date).
(p) Comfort
Letter. On or prior to the First Placement Notice Date and within one (1) Trading Day of each Representation Date in which the
Company is obligated to deliver a certificate pursuant to Section 7(m) for which no waiver is applicable, the Company shall
cause its independent registered public accounting firm (and any other independent accountants whose report is included in the Registration
Statement or the Prospectus) to furnish the Agent letters (the “Comfort Letters”), dated the date the Comfort
Letter is delivered, which shall meet the requirements set forth in this Section 7(p); provided, that if requested by the
Agent, the Company shall cause a Comfort Letter to be furnished to the Agent within 10 Trading Days of the occurrence of any material
transaction or event that necessitates the filing of additional, pro forma, amended or revised financial statements (including any restatement
of previously issued financial statements). Each Comfort Letter shall be in form and substance satisfactory to the Agent and each Comfort
Letter from the Company’s independent registered public accounting firm shall (i) confirm that they are an independent registered
public accounting firm within the meaning of the Securities Act and the PCAOB, (ii) state, as of such date, the conclusions and findings
of such firm with respect to the financial information and other matters ordinarily covered by accountants’ “comfort letters”
to underwriters in connection with registered public offerings (the first such letter, the “Initial Comfort Letter”)
and (iii) update the Initial Comfort Letter with any information that would have been included in the Initial Comfort Letter had
it been given on such date and modified as necessary to relate to the Registration Statement and the Prospectus, as amended and supplemented
to the date of such letter. The Company shall not be required to furnish more than one comfort letter hereunder per each filing of an
annual report on Form 10-K.
(q) Market
Activities. The Company will not, directly or indirectly, and will cause its officers, directors and Subsidiaries not to (i) take
any action designed to cause or result in, or that constitutes or would reasonably be expected to constitute, the stabilization or manipulation
of the price of any security of the Company to facilitate the sale or resale of Ordinary Shares to be issued and sold pursuant to this
Agreement or (ii) sell, bid for, or purchase Ordinary Shares in violation of Regulation M, or pay anyone any compensation for soliciting
purchases of the Placement Shares other than the Agent; provided, however, that the Company may bid for and purchase Ordinary
Shares in accordance with Rule 10b-18 under the Exchange Act.
(r) Insurance.
The Company and its Subsidiaries shall maintain, or cause to be maintained, insurance in such amounts and covering such risks as is reasonable
and customary for the business for which it is engaged.
(s) Compliance
with Laws. The Company and each of its Subsidiaries shall maintain, or cause to be maintained, all material environmental certificates,
authorizations or permits required by federal, state and local law in order to conduct their businesses as described in the Prospectus
(collectively, “Permits”), and the Company and each of its Subsidiaries shall conduct their businesses, or cause their
businesses to be conducted, in substantial compliance with such Permits and with applicable Environmental Laws, except where the failure
to maintain or be in compliance with such Permits could not reasonably be expected to result in a Material Adverse Effect.
(t) Investment
Company Act. The Company will conduct its affairs in such a manner so as to reasonably ensure that neither it nor any of its Subsidiaries
will be or become, at any time prior to the termination of this Agreement, an “investment company,” as such term is defined
in the Investment Company Act.
(u) Securities
Act and Exchange Act. The Company will use its best efforts to comply with all requirements imposed upon it by the Securities Act
and the Exchange Act as from time to time in force, so far as necessary to permit the sales of, or dealings in, the Placement Shares as
contemplated by the provisions hereof and the Prospectus.
(v) No
Offer to Sell. Other than a free writing prospectus (as defined in Rule 405 under the Securities Act) approved in advance by
the Company and the Agent, neither the Agent nor the Company (including its agents and representatives, other than the Agent in its capacity
as agent) will make, use, prepare, authorize, approve or refer to any written communication (as defined in Rule 405 under the Securities
Act), required to be filed with the Commission, that constitutes an offer to sell or solicitation of an offer to buy Placement Shares
hereunder.
(w) Blue
Sky and Other Qualifications. The Company will use its commercially reasonable efforts, in cooperation with the Agent, to qualify
the Placement Shares for offering and sale, or to obtain an exemption for the Placement Shares to be offered and sold, under the applicable
securities laws of such states and other jurisdictions (domestic or foreign) as the Agent may designate and to maintain such qualifications
and exemptions in effect for so long as required for the distribution of the Placement Shares (but in no event for less than one year
from the date of this Agreement); provided, however, that the Company shall not be obligated to file any general consent to service
of process or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in which it is not so qualified or
to subject itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject. In each jurisdiction
in which the Placement Shares have been so qualified or exempt, the Company will file such statements and reports as may be required by
the laws of such jurisdiction to continue such qualification or exemption, as the case may be, in effect for so long as required for the
distribution of the Placement Shares (but in no event for less than one year from the date of this Agreement).
(x) Sarbanes-Oxley
Act. The Company will maintain and keep accurate books and records reflecting its assets and maintain internal accounting controls
in a manner designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial
statements for external purposes in accordance with GAAP and including those policies and procedures that (i) pertain to the maintenance
of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company, (ii) provide
reasonable assurance that transactions are recorded as necessary to permit the preparation of the Company’s financial statements
in accordance with GAAP, (iii) that receipts and expenditures of the Company are being made only in accordance with management’s
and the Company’s directors’ authorization, and (iv) provide reasonable assurance regarding prevention or timely detection
of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on its financial statements.
The Company will maintain such controls and other procedures, including, without limitation, those required by Sections 302 and 906 of
the Sarbanes-Oxley Act, and the applicable regulations thereunder that are designed to ensure that information required to be disclosed
by the Company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within
the time periods specified in the Commission’s rules and forms, including, without limitation, controls and procedures designed
to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is accumulated
and communicated to the Company’s management, including its principal executive officer and principal financial officer, or persons
performing similar functions, as appropriate to allow timely decisions regarding required disclosure and to ensure that material information
relating to the Company is made known to it by others within the Company, particularly during the period in which such periodic reports
are being prepared..
(y) Emerging
Growth Company. The Company will promptly notify the Agent if the company ceases to be an Emerging Growth Company at any time prior
to the completion of the Agent’s distribution of the Placement Shares pursuant to this Agreement.
(z) Renewal
of Registration Statement. If, immediately prior to the third anniversary of the initial effective date of the Registration Statement
(the “Renewal Date”), any of the Placement Shares remain unsold and this Agreement has not been terminated,
the Company, in its sole discretion, may, prior to the Renewal Date, file a new shelf registration statement or, if applicable, an automatic
shelf registration statement relating to the Ordinary Shares that may be offered and sold pursuant to this Agreement (which shall include
a prospectus reflecting the number or amount of Placement Shares that may be offered and sold pursuant to this Agreement), in a form reasonably
satisfactory to the Agent and its counsel, and, if such registration statement is not an automatic shelf registration statement, will
use commercially reasonable efforts to cause such registration statement to be declared effective within 180 days after the Renewal Date.
The Company will take all other reasonable actions necessary or appropriate to permit the public offer and sale of the Placement Shares
to continue as contemplated in the expired registration statement and this Agreement. From and after the effective date thereof, references
herein to the “Registration Statement” shall include such new shelf registration statement or such new automatic shelf registration
statement, as the case may be.
(aa) General
Instruction I.B.6. of Form S-3. If, from and after the date of this Agreement, the Company is no longer eligible to use Form S-3
(including pursuant to General Instruction I.B.6.) at the time it files with the Commission an annual report on Form 10-K or any
post-effective amendment to the Registration Statement, then it shall promptly notify the Agent and, within two Business Days after the
date of filing of such annual report on Form 10-K or amendment to the Registration Statement, the Company shall file a new prospectus
supplement with the Commission reflecting the number of Ordinary Shares available to be offered and sold by the Company under this Agreement
pursuant to General Instruction I.B.6. of Form S-3; provided, however, that the Company may delay the filing of any
such prospectus supplement if, in the reasonable judgment of the Company, it is in the best interest of the Company to do so, provided
that no Placement Notice is in effect or pending during such time. Until such time as the Company shall have corrected such misstatement
or omission or effected such compliance, the Company shall not notify the Agent to resume the offering of Placement Shares.
(bb) Tax
Indemnity. The Company will indemnify and hold harmless the Agent against any documentary, stamp or similar issue tax, including any
interest and penalties, on the issue and sale of the Placement Shares.
(cc) Transfer
Agent. The Company has engaged and will maintain, at its sole expense, a transfer agent and registrar for the Ordinary Shares.
8. Conditions
to the Agent’s Obligations. The obligations of the Agent hereunder with respect to a Placement will be subject to the continuing
accuracy and completeness of the representations and warranties made by the Company herein, to the due performance by the Company of its
obligations hereunder, to the completion by the Agent of a due diligence review satisfactory to the Agent in its reasonable judgment,
and to the continuing satisfaction (or waiver by the Agent in its sole discretion) of the following additional conditions:
(a) Registration
Statement Effective. The Registration Statement shall be effective and shall be available for all offers and sales of Placement Shares
(i) that have been issued pursuant to all prior Placement Notices and (ii) that will be issued pursuant to any Placement Notice.
(b) No Material Notices. None of the
following events shall have occurred and be continuing: (i) receipt by the Company or any of its Subsidiaries of any request
for additional information from the Commission or any other federal or state governmental authority during the period of
effectiveness of the Registration Statement, the response to which would require any post-effective amendments or supplements to the
Registration Statement or the Prospectus; (ii) the issuance by the Commission or any other federal or state governmental
authority of any stop order suspending the effectiveness of the Registration Statement or the initiation of any proceedings for that
purpose; (iii) receipt by the Company or any of its Subsidiaries of any notification with respect to the suspension of the
qualification or exemption from qualification of any of the Placement Shares for sale in any jurisdiction or the initiation or
threatening of any proceeding for such purpose; or (iv) the occurrence of any event that makes any material statement made in
the Registration Statement or the Prospectus or any material Incorporated Document untrue in any material respect or that requires
the making of any changes in the Registration Statement, the Prospectus or Incorporated Documents so that, in the case of the
Registration Statement, it will not contain any untrue statement of a material fact or omit to state any material fact required to
be stated therein or necessary to make the statements therein not misleading and, in the case of the Prospectus, so that it will not
contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to
make the statements therein, in the light of the circumstances under which they were made, not misleading.
(c) No
Misstatement or Material Omission. The Agent shall not have advised the Company that the Registration Statement or Prospectus, or
any amendment or supplement thereto, contains an untrue statement of fact that in the Agent’s opinion is material, or omits to state
a fact that in the Agent’s opinion is material and is required to be stated therein or is necessary to make the statements therein
not misleading.
(d) Material
Changes. Except as contemplated in the Prospectus, or disclosed in the Company’s reports filed with the Commission, there shall
not have been any material adverse change, on a consolidated basis, in the authorized share capital of the Company or any Material Adverse
Effect or any development that could reasonably be expected to result in a Material Adverse Effect, or any downgrading in or withdrawal
of the rating assigned to any of the Company’s securities (other than asset backed securities), if any, by any rating organization
or a public announcement by any rating organization that it has under surveillance or review its rating of any of the Company’s
securities (other than asset backed securities), if any, the effect of which, in the judgment of the Agent (without relieving the Company
of any obligation or liability it may otherwise have), is so material as to make it impracticable or inadvisable to proceed with the offering
of the Placement Shares on the terms and in the manner contemplated in the Prospectus.
(e) Company
Counsel Legal Opinions. The Agent shall have received the opinions and negative assurance letters, as applicable, of U.S. Company
Counsel and Cayman Company Counsel required to be delivered pursuant to Section 7(n) and Section 7(o), as applicable, on
or before the date on which such delivery of such opinions and negative assurance letters are required pursuant to Section 7(n) and
Section 7(o), as applicable.
(f) Agent’s
Counsel Legal Opinion. The Agent shall have received from White & Case LLP, counsel for the Agent, such opinion or opinions,
on or before the date on which the delivery of the U.S. Company Counsel legal opinion is required pursuant to Section 7(n), with
respect to such matters as the Agent may reasonably require, and the Company shall have furnished to such counsel such documents as they
may request to enable them to pass upon such matters.
(g) Comfort
Letter. The Agent shall have received the Comfort Letter required to be delivered pursuant to Section 7(p) on or before
the date on which such delivery of such Comfort Letter is required pursuant to Section 7(p).
(h) Representation
Certificate. The Agent shall have received the certificate required to be delivered pursuant to Section 7(m) on or before
the date on which delivery of such certificate is required pursuant to Section 7(m).
(i) Secretary’s
Certificate. On or prior to the First Placement Notice Date, the Agent shall have received a certificate, signed on behalf of the
Company by the Secretary of the Company and attested to by an executive officer of the Company, dated as of such date and in form and
substance satisfactory to the Agent and its counsel, certifying as to (i) the second amended and restated memorandum and articles
of association of the Company, (ii) the resolutions of the board of directors of the Company or duly authorized committee thereof
authorizing the execution, delivery and performance of this Agreement and the issuance and sale of the Placement Shares and (iii) the
incumbency of the officers of the Company duly authorized to execute this Agreement and the other documents contemplated by this Agreement
(including each of the officers set forth on Schedule 2).
(j) No
Suspension. The Ordinary Shares shall be duly listed, and admitted and authorized for trading, subject to official notice of issuance,
on Nasdaq. Trading of the Ordinary Shares shall not have been suspended on, and the Ordinary Shares shall not have been delisted from,
Nasdaq.
(k) Other
Materials. On each date on which the Company is required to deliver a certificate pursuant to Section 7(m), the Company shall
have furnished to the Agent such appropriate further information, opinions, certificates, letters and other documents as the Agent may
have reasonably requested. All such information, opinions, certificates, letters and other documents shall have been in compliance with
the provisions hereof. The Company shall have furnished the Agent with conformed copies of such opinions, certificates, letters and other
documents as the Agent may have reasonably requested.
(l) Securities
Act Filings Made. All filings with the Commission required by Rule 424(b) or Rule 433 under the Securities Act to have
been filed prior to the issuance of any Placement Notice hereunder shall have been made within the applicable time period prescribed for
such filing by Rule 424(b) (without reliance on Rule 424(b)(8) of the Securities Act) or Rule 433, as applicable.
(m) Approval
for Listing. Either (i) the Placement Shares shall have been approved for listing on Nasdaq, subject only to notice of issuance,
or (ii) the Company shall have filed an application for listing of the Placement Shares on Nasdaq at, or prior to, the First Placement
Notice Date and Nasdaq shall have reviewed such application and not provided any objections thereto.
(n) FINRA.
FINRA shall have raised no objection to the terms of the offering contemplated hereby and the amount of compensation allowable or payable
to the Agent as described in the Prospectus.
(o) No
Termination Event. There shall not have occurred any event that would permit the Agent to terminate this Agreement pursuant to Section 11(a).
9. Indemnification
and Contribution.
(a) Company
Indemnification. The Company agrees to indemnify and hold harmless the Agent, its affiliates and their respective partners, members,
directors, officers, employees and agents, and each person, if any, who (i) controls the Agent within the meaning of Section 15
of the Securities Act or Section 20 of the Exchange Act or (ii) is controlled by or is under common control with the Agent,
in each case from and against any and all losses, claims, liabilities, expenses and damages (including any and all investigative, legal
and other expenses reasonably incurred in connection with, and any and all amounts paid in settlement (in accordance with this Section 9)),
any action, suit, investigation or proceeding between any of the indemnified parties and any indemnifying parties or between any indemnified
party and any third party (including any governmental or self-regulatory authority, or otherwise, or any claim asserted or threatened),
as and when incurred, to which the Agent, or any such other person may become subject under the Securities Act, the Exchange Act or other
federal or state statutory law or regulation, at common law or otherwise, insofar as such losses, claims, liabilities, expenses or damages
arise out of or are based, directly or indirectly, on (x) any untrue statement or alleged untrue statement of a material fact contained
in the Registration Statement or the Prospectus (or any amendment or supplement to the Registration Statement or the Prospectus) or in
any free writing prospectus, or (y) the omission or alleged omission to state in any such document a material fact required to be
stated therein or necessary to make the statements therein (solely with respect to the Prospectus, in light of the circumstances under
which they were made) not misleading; provided, however, that this indemnity agreement shall not apply to the extent that
such loss, claim, liability, expense or damage arises from the sale of the Placement Shares pursuant to this Agreement and is caused,
directly or indirectly, by an untrue statement or omission, or alleged untrue statement or omission, made in reliance upon and in conformity
with the Agent’s Information. This indemnity agreement will be in addition to any liability that the Company might otherwise have.
(b) Agent
Indemnification. The Agent agrees to indemnify and hold harmless the Company and its directors and each officer of the Company who
signed the Registration Statement, and each person, if any, who (i) controls the Company within the meaning of Section 15 of
the Securities Act or Section 20 of the Exchange Act or (ii) is controlled by or is under common control with the Company against
any and all loss, liability, claim, damage and expense described in the indemnity contained in Section 9(a), as incurred, but only
with respect to untrue statements or omissions, or alleged untrue statements or omissions, made in the Registration Statement (or any
amendments thereto) or the Prospectus (or any amendment or supplement thereto) or in any free writing prospectus in reliance upon and
in conformity with the Agent’s Information.
(c) Procedure.
Any party that proposes to assert the right to be indemnified under this Section 9 will, promptly after receipt of notice of commencement
of any action against such party in respect of which a claim is to be made against an indemnifying party or parties under this Section 9,
notify each such indemnifying party of the commencement of such action, enclosing a copy of all papers served, but the omission so to
notify such indemnifying party will not relieve the indemnifying party from (i) any liability that it might have to any indemnified
party otherwise than under this Section 9 and (ii) any liability that it may have to any indemnified party under the foregoing
provision of this Section 9 unless, and only to the extent that, such omission results in the forfeiture of substantive rights or
defenses by the indemnifying party. If any such action is brought against any indemnified party and it notifies the indemnifying party
of its commencement, the indemnifying party will be entitled to participate in and, to the extent that it elects by delivering written
notice to the indemnified party promptly after receiving notice of the commencement of the action from the indemnified party, jointly
with any other indemnifying party similarly notified, to assume the defense of the action, with counsel reasonably satisfactory to the
indemnified party, and after notice from the indemnifying party to the indemnified party of its election to assume the defense, the indemnifying
party will not be liable to the indemnified party for any other documented legal expenses except as provided below and except for the
reasonable costs of investigation subsequently incurred by the indemnified party in connection with the defense. The indemnified party
will have the right to employ its own counsel in any such action, but the fees, expenses and other charges of such counsel will be at
the expense of such indemnified party unless (1) the employment of counsel by the indemnified party has been authorized in writing
by the indemnifying party, (2) the indemnified party has reasonably concluded (based on advice of counsel) that there may be legal
defenses available to it or other indemnified parties that are different from or in addition to those available to the indemnifying party,
(3) a conflict or potential conflict exists (based on advice of counsel to the indemnified party) between the indemnified party and
the indemnifying party (in which case the indemnifying party will not have the right to direct the defense of such action on behalf of
the indemnified party) or (4) the indemnifying party has not in fact employed counsel reasonably satisfactory to the indemnified
party to assume the defense of such action within a reasonable time after receiving notice of the commencement of the action, in each
of which cases the reasonable fees, disbursements and other charges of counsel will be at the expense of the indemnifying party or parties.
It is understood that the indemnifying party or parties shall not, in connection with any proceeding or related proceedings in the same
jurisdiction, be liable for the reasonable and documented fees, disbursements and other charges of more than one separate firm (plus local
counsel) admitted to practice in such jurisdiction at any one time for all such indemnified party or parties. All such fees, disbursements
and other charges will be reimbursed by the indemnifying party within thirty (30) days after the indemnifying party receives a written
invoice relating to such fees, disbursements and other charges in reasonable detail. An indemnifying party will not, in any event, be
liable for any settlement of any action or claim effected without its written consent. No indemnifying party shall, without the prior
written consent of each indemnified party, settle or compromise or consent to the entry of any judgment in any pending or threatened claim,
action or proceeding relating to the matters contemplated by this Section 9 (whether or not any indemnified party is a party thereto),
unless such settlement, compromise or consent (1) includes an unconditional release of each indemnified party, in form and substance
reasonably satisfactory to such indemnified party, from all liability arising out of such claim, action or proceeding and (2) does
not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any indemnified party.
(d) Settlement
Without Consent if Failure to Reimburse. If an indemnified party shall have requested an indemnifying party to reimburse the
indemnified party for reasonable and documented fees and expenses of counsel for which it is entitled to be reimbursed under this Section 9,
such indemnifying party agrees that it shall be liable for any settlement of the nature contemplated by Section 9(a) effected
without its written consent if (i) such settlement is entered into more than 45 days after receipt by such indemnifying party of
the aforesaid request, (ii) such indemnifying party shall have received notice of the terms of such settlement at least 30 days prior
to such settlement being entered into and (iii) such indemnifying party shall not have reimbursed such indemnified party in accordance
with such request prior to the date of such settlement.
(e) Contribution.
In order to provide for just and equitable contribution in circumstances in which the indemnification provided for in the foregoing paragraphs
of this Section 9 is applicable in accordance with its terms but for any reason is held to be unavailable or insufficient from the
Company or the Agent, the Company and the Agent will contribute to the total losses, claims, liabilities, expenses and damages (including
any investigative, legal and other expenses reasonably incurred in connection with, and any amount paid in settlement of, any action,
suit, investigation or proceeding or any claim asserted, but after deducting any contribution received by the Company from persons other
than the Agent, such as persons who control the Company within the meaning of the Securities Act, officers of the Company who signed the
Registration Statement and directors of the Company, who also may be liable for contribution) to which the Company and the Agent may be
subject in such proportion as shall be appropriate to reflect the relative benefits received by the Company on the one hand and the Agent
on the other hand. The relative benefits received by the Company on the one hand and the Agent on the other hand shall be deemed to be
in the same proportion as the total Net Proceeds from the sale of the Placement Shares (before deducting expenses) received by the Company
bear to the total compensation received by the Agent from the sale of Placement Shares on behalf of the Company. If, but only if, the
allocation provided by the foregoing sentence is not permitted by applicable law, the allocation of contribution shall be made in such
proportion as is appropriate to reflect not only the relative benefits referred to in the foregoing sentence but also the relative fault
of the Company, on the one hand, and the Agent, on the other hand, with respect to the statements or omission that resulted in such loss,
claim, liability, expense or damage, or action, suit, investigation or proceeding in respect thereof, as well as any other relevant equitable
considerations with respect to such offering. Such relative fault shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or omission or alleged omission to state a material fact relates to information
supplied by the Company or the Agent, the intent of the parties and their relative knowledge, access to information and opportunity to
correct or prevent such statement or omission. The Company and the Agent agree that it would not be just and equitable if contributions
pursuant to this Section 9(e) were to be determined by pro rata allocation or by any other method of allocation that
does not take into account the equitable considerations referred to herein. The amount paid or payable by an indemnified party as a result
of the loss, claim, liability, expense or damage, or action, suit, investigation or proceeding in respect thereof, referred to above in
this Section 9(e) shall be deemed to include, for the purpose of this Section 9(e), any legal or other expenses reasonably
incurred by such indemnified party in connection with investigating or defending any such action, suit, investigation, proceeding or claim
to the extent consistent with this Section 9. Notwithstanding the foregoing provisions of this Section 9(e), the Agent shall
not be required to contribute any amount in excess of the commissions received by it under this Agreement and no person found guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from
any person who was not guilty of such fraudulent misrepresentation. For purposes of this Section 9(e), any person who controls a
party to this Agreement within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, any affiliates
of the Agent, any partners, members, directors, officers, employees and agents of the Agent and each person that is controlled by or under
common control with the Agent will have the same rights to contribution as that party, and each officer and director of the Company who
signed the Registration Statement will have the same rights to contribution as the Company, subject in each case to the provisions hereof.
Any party entitled to contribution, promptly after receipt of notice of commencement of any action against such party in respect of which
a claim for contribution may be made under this Section 9(e), will notify any such party or parties from whom contribution may be
sought, but the omission to so notify will not relieve that party or parties from whom contribution may be sought from any other obligation
it or they may have under this Section 9(e) except to the extent that the failure to so notify such other party materially prejudiced
the substantive rights or defenses of the party from whom contribution is sought. Except for a settlement entered into pursuant to the
last sentence of Section 9(c) hereof or pursuant to Section 9(d) hereof, no party will be liable for contribution
with respect to any action or claim settled without its written consent if such consent is required pursuant to Section 9(c) hereof.
10. Representations
and Agreements to Survive Delivery. The indemnity and contribution agreements contained in Section 9 of this Agreement and all
representations and warranties of the Company herein or in certificates delivered pursuant hereto shall survive, as of their respective
dates, regardless of (i) any investigation made by or on behalf of the Agent, any controlling persons, or the Company (or any of
their respective officers, directors, employees or controlling persons), (ii) delivery and acceptance of the Placement Shares and
payment therefor or (iii) any termination of this Agreement.
11. Termination.
(a) The
Agent shall have the right, by giving notice as hereinafter specified, at any time to terminate this Agreement if (i) any Material
Adverse Effect, or any development that could reasonably be expected to result in a Material Adverse Effect, has occurred that, in the
judgment of the Agent, may materially impair the ability of the Agent to sell the Placement Shares hereunder, (ii) the Company shall
have failed, refused or been unable to perform any agreement on its part to be performed hereunder; provided, however, in
the case of any failure of the Company to deliver (or cause another person to deliver) any certification, opinion or letter required under
Section 7(m), Section 7(n), Section 7(o) or Section 7(p), the Agent’s right to terminate shall not arise
unless such failure to deliver (or cause to be delivered) continues for more than 15 calendar days from the date such delivery was required,
(iii) any other condition of the Agent’s obligations hereunder is not fulfilled, (iv) any suspension or limitation of
trading in the Placement Shares or in securities generally on Nasdaq shall have occurred, (v) a general banking moratorium shall
have been declared by any of United States federal or New York authorities, or (vi) there shall have occurred any outbreak or escalation
of national or international hostilities or any crisis or calamity, or any change in the United States or international financial markets,
or any substantial change or development involving a prospective substantial change in United States or international political, financial
or economic conditions that, in the judgment of the Agent, may materially impair the ability of the Agent to sell the Placement Shares
hereunder or to enforce contracts for the sale of securities. Any such termination shall be without liability of any party to any other
party except that the provisions of Section 7(g), Section 9, Section 10, Section 16 and Section 17 hereof shall
remain in full force and effect notwithstanding such termination. If the Agent elects to terminate this Agreement as provided in this
Section 11(a), the Agent shall provide the required notice as specified in Section 12.
(b) The
Company shall have the right, by giving 10 days’ prior notice as hereinafter specified, to terminate this Agreement in its sole
discretion at any time after the date of this Agreement. Any such termination shall be without liability of any party to any other party
except that the provisions of Section 7(g), Section 9, Section 10, Section 11(f), Section 16 and Section 17
hereof shall remain in full force and effect notwithstanding such termination.
(c) The
Agent shall have the right, by giving 10 days’ prior notice as hereinafter specified, to terminate this Agreement in its sole discretion
at any time after the date of this Agreement. Any such termination shall be without liability of any party to any other party except that
the provisions of Section 7(g), Section 9, Section 10, Section 11(f), Section 16 and Section 17 hereof shall
remain in full force and effect notwithstanding such termination.
(d) Unless
earlier terminated pursuant to this Section 11, this Agreement shall automatically terminate upon the issuance and sale of all of
the Placement Shares through the Agent on the terms and subject to the conditions set forth herein; provided that the provisions
of Section 7(g), Section 9, Section 10, Section 11(f), Section 16 and Section 17 hereof shall remain in
full force and effect notwithstanding such termination.
(e) This
Agreement shall remain in full force and effect unless terminated pursuant to Sections 11(a), (b), (c), or (d) above or otherwise
by mutual agreement of the parties; provided, however, that any such termination by mutual agreement shall in all cases
be deemed to provide that Section 7(g), Section 9, Section 10, Section 11(f), Section 16 and Section 17
shall remain in full force and effect.
(f) Any
termination of this Agreement shall be effective on the date specified in such notice of termination; provided, however, that such
termination shall not be effective until the close of business on the date of receipt of such notice by the Agent or the Company, as the
case may be. If such termination shall occur prior to the Settlement Date for any sale of Placement Shares, such Placement Shares shall
settle in accordance with the provisions of this Agreement. Upon termination of this Agreement, the Company shall not be required to pay
to the Agent any discount or commission with respect to any Placement Shares not otherwise sold by the Agent under this Agreement; provided,
however, that the Company shall remain obligated to reimburse the Agent’s expenses pursuant to Section 7(g).
12. Notices.
All notices or other communications required or permitted to be given by any party to any other party pursuant to the terms of this Agreement
shall be in writing, unless otherwise specified in this Agreement, and if sent to the Agent, shall be delivered to:
Leerink Partners LLC
1301 Avenue of the Americas, 5th
Floor
New York, New York 10019
Attention: Peter M. Fry
E-mail: peter.fry@leerink.com
with copies (which shall not constitute notice)
to:
Leerink Partners LLC
1301 Avenue of the Americas, 5th
Floor
New York, New York 10019
Attention: Legal Department
E-mail: LegalNotice@leerink.com
White & Case, LLP
1221 Avenue of the Americas
New York, New York 10020
Attention: Jessica Y. Chen
and if to the Company, shall be delivered to:
Zura Bio Limited
Attention: Chief Financial Officer
E-mail: verender.badial@zurabio.com
with a copy (which shall not constitute notice)
to:
Cooley LLP
Attention: Daniel I. Goldberg
E-mail: dgoldberg@cooley.com
Each party to this Agreement may change such address
for notices by sending to the parties to this Agreement written notice of a new address for such purpose. Each such notice or other communication
shall be deemed given (i) when delivered personally on or before 4:30 P.M., New York City time, on a Business Day, or, if such day
is not a Business Day, on the next succeeding Business Day, (ii) by Electronic Notice as set forth in the next paragraph, (iii) on
the next Business Day after timely delivery to a nationally-recognized overnight courier or (iv) on the Business Day actually received
if deposited in the U.S. mail (certified or registered mail, return receipt requested, postage prepaid). For purposes of this Agreement,
“Business Day” shall mean any day on which the Nasdaq and commercial banks in the City of New York are open
for business.
An electronic communication (“Electronic
Notice”) shall be deemed written notice for purposes of this Section 12 if sent to the electronic mail address specified
by the receiving party in Section 12. Electronic Notice shall be deemed received at the time the party sending Electronic Notice
receives actual acknowledgment of receipt from the person whom the notice is sent, other than via auto-reply. Any party receiving Electronic
Notice may request and shall be entitled to receive the notice on paper, in a nonelectronic form (“Nonelectronic Notice”),
which shall be sent to the requesting party within 10 days of receipt of the written request for Nonelectronic Notice.
13. Successors
and Assigns. This Agreement shall inure to the benefit of and be binding upon the Company and the Agent and their respective successors
and the affiliates, controlling persons, officers, directors and other persons referred to in Section 9 hereof. References to any
of the parties contained in this Agreement shall be deemed to include the successors and permitted assigns of each such party. Nothing
in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto, the persons referred to in
the preceding sentence and their respective successors and permitted assigns any rights, remedies, obligations or liabilities under or
by reason of this Agreement, except as expressly provided in this Agreement. Neither party may assign its rights or obligations under
this Agreement without the prior written consent of the other party; provided, however, that the Agent may assign its rights and
obligations hereunder to an affiliate of the Agent without obtaining the Company’s consent, so long as such affiliate is a registered
broker-dealer.
14. Adjustments
for Share Splits. The parties acknowledge and agree that all share-related numbers contained in this Agreement shall be adjusted to
take into account any share split, share dividend or similar event effected with respect to the Ordinary Shares.
15. Entire
Agreement; Amendment; Severability; Waiver. This Agreement (including all schedules (as amended pursuant to this Agreement) and exhibits
attached hereto and Placement Notices issued pursuant hereto) constitutes the entire agreement and supersedes all other prior and contemporaneous
agreements and undertakings, both written and oral, among the parties hereto with regard to the subject matter hereof. Neither this Agreement
nor any term hereof may be amended except pursuant to a written instrument executed by the Company and the Agent; provided, however,
that Schedule 2 of this Agreement may be amended by either party from time to time by sending a notice containing a revised
Schedule 2 to the other party in the manner provided in Section 12 and, upon such amendment, all references herein
to Schedule 2 shall automatically be deemed to refer to such amended Schedule 2. In the event that any one
or more of the provisions contained herein, or the application thereof in any circumstance, is held invalid, illegal or unenforceable
as written by a court of competent jurisdiction, then such provision shall be given full force and effect to the fullest possible extent
that it is valid, legal and enforceable, and the remainder of the terms and provisions herein shall be construed as if such invalid, illegal
or unenforceable term or provision was not contained herein, but only to the extent that giving effect to such provision and the remainder
of the terms and provisions hereof shall be in accordance with the intent of the parties as reflected in this Agreement. No implied waiver
by a party shall arise in the absence of a waiver in writing signed by such party. No failure or delay in exercising any right, power,
or privilege hereunder shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further
exercise thereof or the exercise of any right, power, or privilege hereunder.
16. GOVERNING
LAW AND TIME; WAIVER OF JURY TRIAL. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF
NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAWS. SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME. EACH PARTY HEREBY
IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING
OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.
17. Consent
to Jurisdiction. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the
City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection with any of the transactions contemplated
hereby, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally
subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum, or that the venue
of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process
being served in any such suit, action or proceeding by mailing a copy (certified or registered mail, return receipt requested) to such
party at the address in effect for notices under Section 12 of this Agreement and agrees that such service shall constitute good
and sufficient notice of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process
in any manner permitted by law.
18. Construction.
(a) The
section and exhibit headings herein are for convenience only and shall not affect the construction hereof.
(b) Words
defined in the singular shall have a comparable meaning when used in the plural, and vice versa.
(c) The
words “hereof,” “hereto,” “herein” and “hereunder” and words of similar import, when used
in this Agreement, shall refer to this Agreement as a whole and not to any particular provision of this Agreement.
(d) Wherever
the word “include,” “includes” or “including” is used in this Agreement, it shall be deemed to be
followed by the words “without limitation.”
(e) References
herein to any gender shall include each other gender.
(f) References
herein to any law, statute, ordinance, code, regulation, rule or other requirement of any governmental authority shall be deemed
to refer to such law, statute, ordinance, code, regulation, rule or other requirement of any governmental authority as amended, reenacted,
supplemented or superseded in whole or in part and in effect from time to time and also to all rules and regulations promulgated
thereunder.
19. Permitted
Free Writing Prospectuses. Each of the Company and the Agent represents, warrants and agrees that, unless it obtains the prior written
consent of the other party, which consent shall not be unreasonably withheld, conditioned or delayed, it has not made and will
not make any offer relating to the Placement Shares that would constitute an issuer free writing prospectus, or that would otherwise constitute
a free writing prospectus (as defined in Rule 405), required to be filed with the Commission. Any such free writing prospectus consented
to by the Agent or by the Company, as the case may be, is hereinafter referred to as a “Permitted Free Writing Prospectus.”
The Company represents and warrants that it has treated and agrees that it will treat each Permitted Free Writing Prospectus as an issuer
free writing prospectus, and that it has complied and will comply with the requirements of Rule 433 applicable to any Permitted Free
Writing Prospectus, including timely filing with the Commission where required, legending and record keeping.
20. Absence
of Fiduciary Relationship. The Company acknowledges and agrees that:
(a) the
Agent has been retained to act as sales agent in connection with the sale of the Placement Shares, the Agent has acted at arms’
length and no fiduciary or advisory relationship between the Company or any of its respective affiliates, shareholders (or other equity
holders), creditors or employees or any other party, on the one hand, and the Agent, on the other hand, has been or will be created in
respect of any of the transactions contemplated by this Agreement, irrespective of whether the Agent has advised or is advising the Company
on other matters and the Agent has no duties or obligations to the Company with respect to the transactions contemplated by this Agreement
except the obligations expressly set forth herein;
(b) the
Company is capable of evaluating, and understanding and understands and accepts, the terms, risks and conditions of the transactions contemplated
by this Agreement;
(c) neither
the Agent nor its affiliates have provided any legal, accounting, regulatory or tax advice with respect to the transactions contemplated
by this Agreement and it has consulted its own legal, accounting, regulatory and tax advisors to the extent it has deemed appropriate;
(d) the
Company has been advised and is aware that the Agent and its affiliates are engaged in a broad range of transactions which may
involve interests that differ from those of the Company and that the Agent and its affiliates have no obligation to disclose such interests
and transactions to the Company by virtue of any fiduciary, advisory or agency relationship or otherwise; and
(e) the
Company waives, to the fullest extent permitted by law, any claims it may have against the Agent or its affiliates for breach of
fiduciary duty or alleged breach of fiduciary duty in connection with the transactions contemplated by this Agreement and agrees that
the Agent and its affiliates shall have no liability (whether direct or indirect) to the Company in respect of such a fiduciary claim
or to any person asserting a fiduciary duty claim on behalf of or in right of the Company, including shareholders (or other equity holders),
creditors or employees of the Company.
21. Recognition
of the U.S. Special Resolution Regimes. In the event that the Agent is a Covered Entity and becomes subject to a proceeding under
a U.S. Special Resolution Regime, the transfer from the Agent of this Agreement, and any interest and obligation in or under this Agreement,
will be effective to the same extent as the transfer would be effective under the U.S. Special Resolution Regime if this Agreement, and
any such interest and obligation, were governed by the laws of the United States or a state of the United States.
In the event that the Agent
is a Covered Entity and the Agent or a BHC Act Affiliate of the Agent becomes subject to a proceeding under a U.S. Special Resolution
Regime, Default Rights under this Agreement that may be exercised against the Agent are permitted to be exercised to no greater extent
than such Default Rights could be exercised under the U.S. Special Resolution Regime if this Agreement were governed by the laws of the
United States or a state of the United States.
For purposes of this Agreement,
(A) “BHC Act Affiliate” has the meaning assigned to the term “affiliate” in, and shall be interpreted in
accordance with, 12 U.S.C. § 1841(k); (B) “Covered Entity” means any of the following: (i) a “covered
entity” as that term is defined in, and interpreted in accordance with, 12 C.F.R. § 252.82(b); (ii) a “covered bank”
as that term is defined in, and interpreted in accordance with, 12 C.F.R. § 47.3(b); or (iii) a “covered FSI” as
that term is defined in, and interpreted in accordance with, 12 C.F.R. § 382.2(b); (C) “Default Right” has the meaning
assigned to that term in, and shall be interpreted in accordance with, 12 C.F.R. §§ 252.81, 47.2 or 382.1, as applicable; and
(D) “U.S. Special Resolution Regime” means each of (i) the Federal Deposit Insurance Act and the regulations promulgated
thereunder and (ii) Title II of the Dodd-Frank Wall Street Reform and Consumer Protection Act and the regulations promulgated thereunder.
22. Counterparts.
This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. Delivery of an executed Agreement by one party to the other may be made by facsimile or electronic
transmission. Counterparts may be delivered via facsimile, electronic mail (including any electronic
signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act, the Electronic Signatures and Records Act
or other applicable law, e.g., www.docusign.com) or other transmission method and any counterpart so delivered shall be deemed to have
been duly and validly delivered and be valid and effective for all purposes.
23. Use
of Information. The Agent may not provide any information gained in connection with this Agreement
and the transactions contemplated by this Agreement, including due diligence, to any third party other than its legal counsel advising
it on this Agreement and the transactions contemplated by this Agreement unless expressly approved by the Company in writing.
24. Agent’s
Information. As used in this Agreement, “Agent’s Information” means solely the information in the
seventh paragraph under the heading “Plan of Distribution” in the Prospectus.
All references in this Agreement
to the Registration Statement, the Prospectus or any amendment or supplement to any of the foregoing shall be deemed to include the copy
filed with the Commission pursuant to EDGAR. All references in this Agreement to financial statements and schedules and other information
that is “contained,” “included” or “stated” in the Registration Statement or the Prospectus (and all
other references of like import) shall be deemed to mean and include all such financial statements and schedules and other information
that is incorporated by reference in the Registration Statement or the Prospectus, as the case may be.
All
references in this Agreement to “supplements” to the Prospectus shall include any supplements, “wrappers” or similar
materials prepared in connection with any offering, sale or private placement of any Placement Shares by the Agent outside of the
United States.
[Remainder of Page Intentionally Blank]
If
the foregoing correctly sets forth the understanding between the Company and the Agent, please so indicate in the space provided
below for that purpose, whereupon this letter shall constitute a binding agreement between the Company and the Agent.
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Very truly yours, |
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ZURA BIO LIMITED |
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By: |
/s/
Verender Badial |
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Name: Verender Badial |
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Title: Chief Financial Officer |
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ACCEPTED as of the date |
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first-above written: |
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LEERINK PARTNERS LLC |
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By: |
/s/ Peter M. Fry |
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Name: Peter M. Fry |
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Title: Head of Alternative Equities |
SCHEDULE 1
FORM OF PLACEMENT NOTICE
From: |
[●] |
Cc: |
[●] |
To: |
Leerink Partners LLC |
Subject: |
Leerink Partners —At the Market Offering—Placement Notice |
Ladies and Gentlemen:
Pursuant
to the terms and subject to the conditions contained in the Sales Agreement, dated September 3, 2024 (the “Agreement”),
by and between Zura Bio Limited, a Cayman Islands exempted company (the “Company”), and Leerink Partners LLC
(“Leerink Partners”), I hereby request on behalf of the Company that Leerink Partners sell up to [●]
Class A ordinary shares, US$0.0001 par value per share, of the Company (the “Shares”), at a minimum market
price of US$[●] per share[; provided that no more than [●] Shares shall be sold in any one Trading Day (as such term
is defined in Section 3 of the Agreement)]. Sales should begin on the date of this Placement Notice and shall continue until [DATE]
[all Shares that are the subject of this Placement Notice are sold].
SCHEDULE 2
The Company
Robert Lisicki, Chief Executive Officer
Verender Badial, Chief Financial Officer
Kim Davis, Chief Legal Officer & Corporate Secretary
Leerink Partners
Dan Dubin, M.D.
Sean Pitt
atm@leerink.com
SCHEDULE 3
Compensation
The
Company shall pay Leerink Partners compensation, in cash, equal to 3.0% of the gross proceeds from the sales of Placement Shares
pursuant to the terms of the Sales Agreement of which this Schedule 3 forms a part.
Exhibit 7(m)
Form of Representation Date Certificate
Each
of [●], the duly qualified and elected Chief Executive Officer of Zura Bio Limited, a Cayman Islands exempted company (the “Company”),
and [●], the duly qualified and elected Chief Financial Officer of the Company, does hereby certify in such respective capacity
and on behalf of the Company, pursuant to Section 7(m) of the Sales Agreement, dated September 3, 2024 (the “Sales
Agreement”), by and between the Company and Leerink Partners LLC, that, after due inquiry, to the best of the knowledge
of the undersigned:
(i) The
representations and warranties of the Company in Section 6 of the Sales Agreement (A) to the extent such representations and
warranties are subject to qualifications and exceptions contained therein relating to materiality or Material Adverse Effect, are true
and correct on and as of the date hereof with the same force and effect as if expressly made on and as of the date hereof, except for
those representations and warranties that speak solely as of a specific date and which were true and correct as of such date, and (B) to
the extent such representations and warranties are not subject to any qualifications or exceptions relating to materiality or Material
Adverse Effect, are true and correct in all material respects as of the date hereof as if made on and as of the date hereof with the same
force and effect as if expressly made on and as of the date hereof, except for those representations and warranties that speak solely
as of a specific date and which were true and correct as of such date.
(ii) The
Company has complied with all agreements and satisfied all conditions on its part to be performed or satisfied pursuant to the Sales Agreement
at or prior to the date hereof.
(iii) As
of the date hereof, (A) the Registration Statement complies in all material respects with the requirements of the Securities Act
and does not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary
in order to make the statements therein not misleading, (B) the Prospectus complies in all material respects with the requirements
of the Securities Act does not contain any untrue statement of a material fact or omit to state a material fact required to be stated
therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading
and (C) no event has occurred as a result of which it is necessary to amend or supplement the Registration Statement or the Prospectus
in order to make the statements therein not untrue or misleading or for clauses (A) and (B) above, to be true and correct.
(iv) There
has been no material adverse change, or any development that could reasonably be expected to result in a material adverse change, in the
condition (financial or otherwise), earnings, results of operations, business, properties, operations, assets, liabilities or prospects
of the Company and its Subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course of business, since
the date as of which information is given in the Prospectus, as amended or supplemented to the date hereof.
(v) The
Company does not possess any material non-public information.
(vi) The
maximum amount of Placement Shares that may be sold pursuant to the Sales Agreement has been duly authorized by the Company’s board
of directors or a duly authorized committee thereof pursuant to a resolution or unanimous written consent in accordance with the Company’s
amended and restated articles of incorporation, amended and restated bylaws and applicable law.
Cooley
LLP, Ogier (Cayman) LLP and White & Case LLP are entitled to rely on this certificate in connection with the respective
opinions such firms are rendering pursuant to the Sales Agreement.
Capitalized terms used but
not defined herein shall have the meanings ascribed to them in the Sales Agreement.
IN WITNESS WHEREOF, each of
the undersigned, in such individual’s respective capacity as Chief Executive Officer or Chief Financial Officer of the Company,
has executed this Officers’ Certificate on behalf of the Company.
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By: |
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Name: |
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Title: Chief Executive Officer |
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Date: |
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By: |
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Name: |
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Title: Chief Financial Officer |
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Date: |
[Company Signature Page to Officers’
Certificate]
Exhibit 4.3
Zura
Bio Limited,
Issuer
AND
[TRUSTEE],
Trustee
INDENTURE
Dated as of [•], 20__
Debt Securities
Table
Of Contents
Page
Section 1.01 |
Definitions of Terms |
1 |
article 2 |
ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES |
5 |
Section 2.01 |
Designation and Terms of Securities |
5 |
Section 2.02 |
Form of Securities and Trustee’s Certificate |
8 |
Section 2.03 |
Denominations: Provisions for Payment |
8 |
Section 2.04 |
Execution and Authentications |
10 |
Section 2.05 |
Registration of Transfer and Exchange |
10 |
Section 2.06 |
Temporary Securities |
12 |
Section 2.07 |
Mutilated, Destroyed, Lost or Stolen Securities |
12 |
Section 2.08 |
Cancellation |
13 |
Section 2.09 |
Benefits of Indenture |
13 |
Section 2.10 |
Authenticating Agent |
13 |
Section 2.11 |
Global Securities |
14 |
Section 2.12 |
CUSIP Numbers |
15 |
article 3 |
REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS |
15 |
Section 3.01 |
Redemption |
15 |
Section 3.02 |
Notice of Redemption |
15 |
Section 3.03 |
Payment Upon Redemption |
17 |
Section 3.04 |
Sinking Fund |
17 |
Section 3.05 |
Satisfaction of Sinking Fund Payments with Securities |
17 |
Section 3.06 |
Redemption of Securities for Sinking Fund |
18 |
Section 4.01 |
Payment of Principal, Premium and Interest |
18 |
Section 4.02 |
Maintenance of Office or Agency |
18 |
Section 4.03 |
Paying Agents |
19 |
Section 4.04 |
Appointment to Fill Vacancy in Office of Trustee |
20 |
Table
Of Contents
(continued)
Page
article 5 |
SECURITYHOLDERS’ LISTS AND REPORTS BY THE COMPANY AND THE TRUSTEE |
20 |
Section 5.01 |
Company to Furnish Trustee Names and Addresses of Securityholders |
20 |
Section 5.02 |
Preservation Of Information; Communications With Securityholders |
20 |
Section 5.03 |
Reports by the Company |
21 |
Section 5.04 |
Reports by the Trustee |
21 |
article 6 |
REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT |
22 |
Section 6.01 |
Events of Default |
22 |
Section 6.02 |
Collection of Indebtedness and Suits for Enforcement by Trustee |
24 |
Section 6.03 |
Application of Moneys Collected |
25 |
Section 6.04 |
Limitation on Suits |
25 |
Section 6.05 |
Rights and Remedies Cumulative; Delay or Omission Not Waiver |
26 |
Section 6.06 |
Control by Securityholders |
27 |
Section 6.07 |
Undertaking to Pay Costs |
27 |
article 7 |
CONCERNING THE TRUSTEE |
28 |
Section 7.01 |
Certain Duties and Responsibilities of Trustee |
28 |
Section 7.02 |
Certain Rights of Trustee |
29 |
Section 7.03 |
Trustee Not Responsible for Recitals or Issuance or Securities |
31 |
Section 7.04 |
May Hold Securities |
31 |
Section 7.05 |
Moneys Held in Trust |
31 |
Section 7.06 |
Compensation and Reimbursement |
32 |
Section 7.07 |
Reliance on Officer’s Certificate |
32 |
Section 7.08 |
Disqualification; Conflicting Interests |
33 |
Section 7.09 |
Corporate Trustee Required; Eligibility |
33 |
Section 7.10 |
Resignation and Removal; Appointment of Successor |
33 |
Section 7.11 |
Acceptance of Appointment By Successor |
34 |
Section 7.12 |
Merger, Conversion, Consolidation or Succession to Business |
36 |
Table
Of Contents
(continued)
Page
Section 7.13 |
Preferential Collection of Claims Against the Company |
36 |
Section 7.14 |
Notice of Default |
36 |
article 8 |
CONCERNING THE SECURITYHOLDERS |
36 |
Section 8.01 |
Evidence of Action by Securityholders |
36 |
Section 8.02 |
Proof of Execution by Securityholders |
37 |
Section 8.03 |
Who May be Deemed Owners |
37 |
Section 8.04 |
Certain Securities Owned by Company Disregarded |
38 |
Section 8.05 |
Actions Binding on Future Securityholders |
38 |
article 9 |
SUPPLEMENTAL INDENTURES |
39 |
Section 9.01 |
Supplemental Indentures Without the Consent of Securityholders |
39 |
Section 9.02 |
Supplemental Indentures With Consent of Securityholders |
40 |
Section 9.03 |
Effect of Supplemental Indentures |
40 |
Section 9.04 |
Securities Affected by Supplemental Indentures |
40 |
Section 9.05 |
Execution of Supplemental Indentures |
40 |
article 10 |
SUCCESSOR ENTITY |
41 |
Section 10.01 |
Company May Consolidate, Etc. |
41 |
Section 10.02 |
Successor Entity Substituted |
42 |
article 11 |
SATISFACTION AND DISCHARGE |
42 |
Section 11.01 |
Satisfaction and Discharge of Indenture |
42 |
Section 11.02 |
Discharge of Obligations |
43 |
Section 11.03 |
Deposited Moneys to be Held in Trust |
43 |
Section 11.04 |
Payment of Moneys Held by Paying Agents |
43 |
Section 11.05 |
Repayment to Company |
43 |
article 12 |
IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND DIRECTORS |
44 |
Section 12.01 |
No Recourse |
44 |
article 13 |
MISCELLANEOUS PROVISIONS |
44 |
Section 13.01 |
Effect on Successors and Assigns |
44 |
Section 13.02 |
Actions by Successor |
44 |
Section 13.03 |
Surrender of Company Powers |
44 |
Table
Of Contents
(continued)
Page
Section 13.04 |
Notices |
45 |
Section 13.05 |
Governing Law; Jury Trial Waiver |
45 |
Section 13.06 |
Treatment of Securities as Debt |
45 |
Section 13.07 |
Certificates and Opinions as to Conditions Precedent |
45 |
Section 13.08 |
Payments on Business Days |
46 |
Section 13.09 |
Conflict with Trust Indenture Act |
46 |
Section 13.10 |
Counterparts |
46 |
Section 13.11 |
Separability |
46 |
Section 13.12 |
Compliance Certificates |
47 |
Section 13.13 |
Patriot Act |
47 |
Section 13.14 |
Force Majeure |
47 |
Section 13.12 |
Table of Contents; Headings |
47 |
INDENTURE
Indenture,
dated as of [·], 20__, among Zura Bio Limited,
an exempted company incorporated under the laws of the Cayman Islands (the “Company”), and[Trustee],
as trustee (the “Trustee”):
Whereas,
for its lawful corporate purposes, the Company has duly authorized the execution and delivery of this Indenture to provide for the issuance
of debt securities (hereinafter referred to as the “Securities”), in an unlimited aggregate principal amount to be issued
from time to time in one or more series as in this Indenture provided, as registered Securities without coupons, to be authenticated by
the certificate of the Trustee;
Whereas,
to provide the terms and conditions upon which the Securities are to be authenticated, issued and delivered, the Company has duly authorized
the execution of this Indenture; and
Whereas,
all things necessary to make this Indenture a valid agreement of the Company, in accordance with its terms, have been done.
Now,
Therefore, in consideration of the premises and the purchase of the Securities by the holders thereof, it is mutually covenanted
and agreed as follows for the equal and ratable benefit of the holders of Securities:
article
1
DEFINITIONS
Section
1.01 Definitions of Terms.
The terms defined in this
Section (except as in this Indenture or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise
requires) for all purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in
this Section and shall include the plural as well as the singular. All other terms used in this Indenture that are defined in the Trust
Indenture Act of 1939, as amended, or that are by reference in such Act defined in the Securities Act of 1933, as amended (except as
herein or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise requires), shall have the meanings
assigned to such terms in said Trust Indenture Act and in said Securities Act as in force at the date of the execution of this instrument.
“Authenticating
Agent” means the Trustee or an authenticating agent with respect to all or any of the series of Securities appointed by
the Trustee pursuant to Section 2.10.
“Board of Directors”
means the Board of Directors (or the functional equivalent thereof) of the Company or any duly authorized committee of such Board.
“Board Resolution”
means a copy of a resolution certified by the Secretary or an Assistant Secretary of the Company to have been duly adopted by the Board
of Directors (or duly authorized committee thereof) and to be in full force and effect on the date of such certification.
“Business Day”
means, with respect to any series of Securities, any day other than a day on which federal or state banking institutions in the Borough
of Manhattan, the City of New York, or in the city of the Corporate Trust Office of the Trustee, are authorized or obligated by law,
executive order or regulation to close.
“Commission”
means the Securities and Exchange Commission, as from time to time constituted, created under the Exchange Act, or, if at any time after
the execution of this instrument such Commission is not existing and performing the duties now assigned to it under the Trust Indenture
Act, then the body performing such duties at such time.
“Company”
means Zura Bio Limited, an exempted company incorporated under the laws of the Cayman
Islands, and, subject to the provisions of Article Ten, shall also include its successors and assigns.
“Corporate Trust
Office” means the office of the Trustee at which, at any particular time, its corporate trust business shall be principally
administered, which office at the date hereof is located at
.
“Custodian”
means any receiver, trustee, assignee, liquidator or similar official under any Insolvency Law.
“Defaulted Interest”
has the meaning set forth in Section 2.03.
“Depositary”
means, with respect to Securities of any series for which the Company shall determine that such Securities will be issued as a Global
Security, The Depository Trust Company, another clearing agency, or any successor registered as a clearing agency under the Exchange
Act, or other applicable statute or regulation, which, in each case, shall be designated by the Company pursuant to either Section 2.01
or 2.11.
“Event of Default”
means, with respect to Securities of a particular series, any event specified in Section 6.01, continued for the period of time, if any,
therein designated.
“Exchange Act”
means the United States Securities and Exchange Act of 1934, as amended, and the rules and regulations promulgated by the Commission
thereunder.
“Global Security”
means a Security issued to evidence all or a part of any series of Securities which is executed by the Company and authenticated and
delivered by the Trustee to the Depositary or pursuant to the Depositary’s instruction, all in accordance with the Indenture, which
shall be registered in the name of the Depositary or its nominee.
“Governmental
Obligations” means securities that are (a) direct obligations of the United States of America for the payment of which
its full faith and credit is pledged or (b) obligations of a Person controlled or supervised by and acting as an agency or instrumentality
of the United States of America, the payment of which is unconditionally guaranteed as a full faith and credit obligation by the United
States of America that, in either case, are not callable or redeemable at the option of the issuer thereof at any time prior to the stated
maturity of the Securities, and shall also include a depositary receipt issued by a bank or trust company as custodian with respect to
any such Governmental Obligation or a specific payment of principal of or interest on any such Governmental Obligation held by such custodian
for the account of the holder of such depositary receipt; provided, however, that (except as required by law) such custodian is not authorized
to make any deduction from the amount payable to the holder of such depositary receipt from any amount received by the custodian in respect
of the Governmental Obligation or the specific payment of principal of or interest on the Governmental Obligation evidenced by such depositary
receipt.
“herein”,
“hereof” and “hereunder”, and other words of similar import, refer to this Indenture
as a whole and not to any particular Article, Section or other subdivision.
“Indenture”
means this instrument as originally executed or as it may from time to time be supplemented or amended by one or more indentures supplemental
hereto entered into in accordance with the terms hereof and shall include the terms of particular series of Securities established as
contemplated by Section 2.01.
“Insolvency law”
means the Companies Law (2016 Revision), the Companies Winding Up Rules, the Insolvency Practitioners’ Regulations and the Foreign
Bankruptcy Proceedings (International Cooperation Rules) of the Cayman Islands.
“Interest Payment
Date”, when used with respect to any installment of interest on a Security of a particular series, means the date specified
in such Security or in a Board Resolution or in an indenture supplemental hereto with respect to such series as the fixed date on which
an installment of interest with respect to Securities of that series is due and payable.
“Officer”
means, with respect to the Company, the chairman of the Board of Directors, a chief executive officer, a president, a chief financial
officer, a chief operating officer, any executive vice president, any senior vice president, any vice president, the treasurer or any
assistant treasurer, the controller or any assistant controller or the secretary or any assistant secretary.
“Officer’s
Certificate” means a certificate signed by any Officer. Each such certificate shall include the statements provided for
in Section 13.07, if and to the extent required by the provisions thereof.
“Opinion of Counsel”
means an opinion in writing subject to customary exceptions of legal counsel, who may be an employee of or counsel for the Company, that
is delivered to the Trustee in accordance with the terms hereof. Each such opinion shall include the statements provided for in Section
13.07, if and to the extent required by the provisions thereof.
“Outstanding”,
when used with reference to Securities of any series, means, subject to the provisions of Section 8.04, as of any particular time, all
Securities of that series theretofore authenticated and delivered by the Trustee under this Indenture, except (a) Securities theretofore
canceled by the Trustee or any paying agent, or delivered to the Trustee or any paying agent for cancellation or that have previously
been canceled; (b) Securities or portions thereof for the payment or redemption of which moneys or Governmental Obligations in the necessary
amount shall have been deposited in trust with the Trustee or with any paying agent (other than the Company) or shall have been set aside
and segregated in trust by the Company (if the Company shall act as its own paying agent); provided, however, that if such Securities
or portions of such Securities are to be redeemed prior to the maturity thereof, notice of such redemption shall have been given as provided
in Article Three, or provision satisfactory to the Trustee shall have been made for giving such notice; and (c) Securities in lieu of
or in substitution for which other Securities shall have been authenticated and delivered pursuant to the terms of Section 2.07.
“Person”
means any individual, corporation, partnership, joint venture, joint-stock company, limited liability company, association, trust, unincorporated
organization, any other entity or organization, including a government or political subdivision or an agency or instrumentality thereof.
“Predecessor
Security” of any particular Security means every previous Security evidencing all or a portion of the same debt as that
evidenced by such particular Security; and, for the purposes of this definition, any Security authenticated and delivered under Section
2.07 in lieu of a lost, destroyed or stolen Security shall be deemed to evidence the same debt as the lost, destroyed or stolen Security.
“Responsible
Officer” when used with respect to the Trustee means any officer within the Corporate Trust Office of the Trustee (or any
successor group of the Trustee) or any other officer of the Trustee customarily performing functions similar to those performed by any
of the above designated officers and also means, with respect to a particular corporate trust matter, any other officer to whom such
matter is referred because of his or her knowledge of and familiarity with the particular subject and in each case who shall have direct
responsibility for the administration of this Indenture.
“Securities”
has the meaning stated in the first recital of this Indenture and more particularly means any Securities authenticated and delivered
under this Indenture.
“Securities Act” means
the Securities Act of 1933, as amended.
“Securityholder”, “holder
of Securities”, “registered holder”, or other similar term, means the Person or Persons in whose
name or names a particular Security is registered on the Security Register kept for that purpose in accordance with the terms of this
Indenture.
“Security Register”
and “Security Registrar” shall have the meanings as set forth in Section 2.05.
“Subsidiary” means,
with respect to any Person, any corporation, association, partnership or other business entity of which more than 50% of the total voting
power of shares of capital stock or other interests (including partnership interests) entitled (without regard to the occurrence of any
contingency) to vote in the election of directors, managers, general partners or trustees thereof is at the time owned or controlled,
directly or indirectly, by (i) such Person; (ii) such Person and one or more Subsidiaries of such Person; or (iii) one or more Subsidiaries
of such Person.
“Trustee”
means _________________________, and, subject to the provisions of Article Seven, shall also include its successors and assigns, and,
if at any time there is more than one Person acting in such capacity hereunder, “Trustee” shall mean each such Person. The
term “Trustee” as used with respect to a particular series of the Securities shall mean the trustee with respect to that
series.
“Trust Indenture
Act” means the Trust Indenture Act of 1939, as amended.
“U.S.A.
Patriot Act” means the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct
Terrorism Act of 2001, Pub. L. 107-56, as amended and signed into law October 26, 2001.
article
2
ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES
Section
2.01 Designation and Terms of Securities.
(a) The
aggregate principal amount of Securities that may be authenticated and delivered under this Indenture is unlimited. The Securities may
be issued in one or more series up to the aggregate principal amount of Securities of that series from time to time authorized by or
pursuant to a Board Resolution or pursuant to one or more indentures supplemental hereto. Prior to the initial issuance of Securities
of any series, there shall be established in or pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established
in one or more indentures supplemental hereto:
(1)
the title of the Securities of the series (which shall distinguish the Securities of that series from all other Securities);
(2)
any limit upon the aggregate principal amount of the Securities of that series that may be authenticated and delivered under
this Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of,
other Securities of that series);
(3)
the maturity date or dates on which the principal of the Securities of the series is payable;
(4)
the form of the Securities of the series including the form of the certificate of authentication for such series;
(5)
the applicability of any guarantees;
(6)
whether or not the Securities will be secured or unsecured, and the terms of any secured debt;
(7)
whether the Securities rank as senior debt, senior subordinated debt, subordinated debt or any combination thereof, and the
terms of any subordination;
(8)
if the price (expressed as a percentage of the aggregate principal amount thereof) at which such Securities will be issued
is a price other than the principal amount thereof, the portion of the principal amount thereof payable upon declaration of acceleration
of the maturity thereof, or if applicable, the portion of the principal amount of such Securities that is convertible into another security
or the method by which any such portion shall be determined;
(9)
the interest rate or rates, which may be fixed or variable, or the method for determining the rate and the date interest will
begin to accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method for determining
such dates;
(10)
the Company’s right, if any, to defer the payment of interest and the maximum length of any such deferral period;
(11)
if applicable, the date or dates after which, or the period or periods during which, and the price or prices at which, the
Company may at its option, redeem the series of Securities pursuant to any optional or provisional redemption provisions and the terms
of those redemption provisions;
(12)
the date or dates, if any, on which, and the price or prices at which the Company is obligated, pursuant to any mandatory
sinking fund or analogous fund provisions or otherwise, to redeem, or at the Securityholder’s option to purchase, the series of
Securities and the currency or currency unit in which the Securities are payable;
(13)
the denominations in which the Securities of the series shall be issuable, if other than denominations of one thousand U.S.
dollars ($1,000) or any integral multiple thereof;
(14)
any and all terms, if applicable, relating to any auction or remarketing of the Securities of that series and any security
for the obligations of the Company with respect to such Securities and any other terms which may be advisable in connection with the
marketing of Securities of that series;
(15)
whether the Securities of the series shall be issued in whole or in part in the form of a Global Security or Securities; the
terms and conditions, if any, upon which such Global Security or Securities may be exchanged in whole or in part for other individual
Securities; and the Depositary for such Global Security or Securities;
(16)
if applicable, the provisions relating to conversion or exchange of any Securities of the series and the terms and conditions
upon which such Securities will be so convertible or exchangeable, including the conversion or exchange price, as applicable, or how
it will be calculated and may be adjusted, any mandatory or optional (at the Company’s option or the holders’ option) conversion
or exchange features, the applicable conversion or exchange period and the manner of settlement for any conversion or exchange, which
may, without limitation, include the payment of cash as well as the delivery of securities;
(17)
if other than the full principal amount thereof, the portion of the principal amount of Securities of the series which shall
be payable upon declaration of acceleration of the maturity thereof pursuant to Section 6.01;
(18)
additions to or changes in the covenants applicable to the series of Securities being issued, including, among others, the
consolidation, merger or sale covenant;
(19)
additions to or changes in the Events of Default with respect to the Securities and any change in the right of the Trustee
or the Securityholders to declare the principal, premium, if any, and interest, if any, with respect to such Securities to be due and
payable;
(20)
additions to or changes in or deletions of the provisions relating to covenant defeasance and legal defeasance;
(21)
additions to or changes in the provisions relating to satisfaction and discharge of this Indenture;
(22)
additions to or changes in the provisions relating to the modification of this Indenture both with and without the consent
of Securityholders of Securities issued under this Indenture;
(23)
the currency of payment of Securities if other than U.S. dollars and the manner of determining the equivalent amount in U.S.
dollars;
(24)
whether interest will be payable in cash or additional Securities at the Company’s or the Securityholders’ option
and the terms and conditions upon which the election may be made;
(25)
the terms and conditions, if any, upon which the Company shall pay amounts in addition to the stated interest, premium, if
any and principal amounts of the Securities of the series to any Securityholder that is not a “United States person” for
federal tax purposes;
(26)
any restrictions on transfer, sale or assignment of the Securities of the series; and
(27)
any other specific terms, preferences, rights or limitations of, or restrictions on, the Securities, any other additions or
changes in the provisions of this Indenture, and any terms that may be required by us or advisable under applicable laws or regulations.
All Securities of any one
series shall be substantially identical except as may otherwise be provided in or pursuant to any such Board Resolution or in any indentures
supplemental hereto.
If any of the terms of the
series are established by action taken pursuant to a Board Resolution of the Company, a copy of an appropriate record of such action
shall be certified by the secretary or an assistant secretary of the Company and delivered to the Trustee at or prior to the delivery
of the Officer’s Certificate of the Company setting forth the terms of the series.
Securities of any particular
series may be issued at various times, with different dates on which the principal or any installment of principal is payable, with different
rates of interest, if any, or different methods by which rates of interest may be determined, with different dates on which such interest
may be payable and with different redemption dates.
Section
2.02 Form of Securities and Trustee’s Certificate.
The Securities of any series
and the Trustee’s certificate of authentication to be borne by such Securities shall be substantially of the tenor and purport
as set forth in one or more indentures supplemental hereto or as provided in a Board Resolution, and set forth in an Officer’s
Certificate, and they may have such letters, numbers or other marks of identification or designation and such legends or endorsements
printed, lithographed or engraved thereon as the Company may deem appropriate and as are not inconsistent with the provisions of this
Indenture, or as may be required to comply with any law or with any rule or regulation made pursuant thereto or with any rule or regulation
of any securities exchange on which Securities of that series may be listed, or to conform to usage.
Section
2.03 Denominations: Provisions for Payment.
The Securities shall be issuable
as registered Securities and in the denominations of one thousand U.S. dollars ($1,000) or any integral multiple thereof, subject to
Section 2.01(a)(13). The Securities of a particular series shall bear interest payable on the dates and at the rate specified with respect
to that series. Subject to Section 2.01(a)(23), the principal of and the interest on the Securities of any series, as well as any premium
thereon in case of redemption or repurchase thereof prior to maturity, and any cash amount due upon conversion or exchange thereof, shall
be payable in the coin or currency of the United States of America that at the time is legal tender for public and private debt, at the
office or agency of the Company maintained for that purpose. Each Security shall be dated the date of its authentication. Interest on
the Securities shall be computed on the basis of a 360-day year composed of twelve 30-day months.
The interest installment
on any Security that is payable, and is punctually paid or duly provided for, on any Interest Payment Date for Securities of that series
shall be paid to the Person in whose name said Security (or one or more Predecessor Securities) is registered at the close of business
on the regular record date for such interest installment. In the event that any Security of a particular series or portion thereof is
called for redemption and the redemption date is subsequent to a regular record date with respect to any Interest Payment Date and prior
to such Interest Payment Date, interest on such Security will be paid upon presentation and surrender of such Security as provided in
Section 3.03.
Any interest on any Security
that is payable, but is not punctually paid or duly provided for, on any Interest Payment Date for Securities of the same series (herein
called “Defaulted Interest”) shall forthwith cease to be payable to the registered holder on the relevant regular record
date by virtue of having been such holder; and such Defaulted Interest shall be paid by the Company, at its election, as provided in
clause (1) or clause (2) below:
(1)
The Company may make payment of any Defaulted Interest on Securities to the Persons in whose names such Securities (or their
respective Predecessor Securities) are registered in the Security Register at the close of business on a special record date for the
payment of such Defaulted Interest, which shall be fixed in the following manner: the Company shall notify the Trustee in writing of
the amount of Defaulted Interest proposed to be paid on each such Security and the date of the proposed payment, and at the same time
the Company shall deposit with the Trustee an amount of money equal to the aggregate amount proposed to be paid in respect of such Defaulted
Interest or shall make arrangements satisfactory to the Trustee for such deposit prior to the date of the proposed payment, such money
when deposited to be held in trust for the benefit of the Persons entitled to such Defaulted Interest as in this clause provided. Thereupon
the Trustee shall fix a special record date for the payment of such Defaulted Interest which shall not be more than 15 nor less than
10 days prior to the date of the proposed payment and not less than 10 days after the receipt by the Trustee of the notice of the proposed
payment. The Trustee shall promptly notify the Company of such special record date and, in the name and at the expense of the Company,
shall cause notice of the proposed payment of such Defaulted Interest and the special record date therefor to be sent, to each Securityholder
at his or her address as it appears in the Security Register (as hereinafter defined), not less than 10 days prior to such special record
date. Notice of the proposed payment of such Defaulted Interest and the special record date therefor having been sent as aforesaid, such
Defaulted Interest shall be paid to the Persons in whose names such Securities (or their respective Predecessor Securities) are registered
on such special record date.
(2)
The Company may make payment of any Defaulted Interest on any Securities in any other lawful manner not inconsistent with
the requirements of any securities exchange on which such Securities may be listed, and upon such notice as may be required by such exchange,
if, after notice given by the Company to the Trustee of the proposed payment pursuant to this clause, such manner of payment shall be
deemed practicable by the Trustee.
Unless otherwise set forth
in a Board Resolution or one or more indentures supplemental hereto establishing the terms of any series of Securities pursuant to Section
2.01 hereof, the term “regular record date” as used in this Section with respect to a series of Securities and any Interest
Payment Date for such series shall mean either the fifteenth day of the month immediately preceding the month in which an Interest Payment
Date established for such series pursuant to Section 2.01 hereof shall occur, if such Interest Payment Date is the first day of a month,
or the first day of the month in which an Interest Payment Date established for such series pursuant to Section 2.01 hereof shall occur,
if such Interest Payment Date is the fifteenth day of a month, whether or not such date is a Business Day.
Subject to the foregoing
provisions of this Section, each Security of a series delivered under this Indenture upon transfer of or in exchange for or in lieu of
any other Security of such series shall carry the rights to interest accrued and unpaid, and to accrue, that were carried by such other
Security.
Section
2.04 Execution and Authentications.
The Securities shall be signed
on behalf of the Company by one of its Officers. Signatures may be in the form of a manual or facsimile signature.
The Company may use the facsimile
signature of any Person who shall have been an Officer (at the time of execution), notwithstanding the fact that at the time the Securities
shall be authenticated and delivered or disposed of such Person shall have ceased to be such an officer of the Company. The Securities
may contain such notations, legends or endorsements required by law, stock exchange rule or usage. Each Security shall be dated the date
of its authentication by the Trustee.
A Security shall not be valid
until authenticated manually by an authorized signatory of the Trustee, or by an Authenticating Agent. Such signature shall be conclusive
evidence that the Security so authenticated has been duly authenticated and delivered hereunder and that the holder is entitled to the
benefits of this Indenture. At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver
Securities of any series executed by the Company to the Trustee for authentication, together with a written order of the Company for
the authentication and delivery of such Securities, signed by an Officer, and the Trustee in accordance with such written order shall
authenticate and deliver such Securities.
Upon
the Company’s delivery of any such authentication order to the Trustee at any time after the initial issuance of Securities under
this Indenture, the Trustee shall be provided with, and (subject to Sections 315(a) through 315(d) of the Trust Indenture Act) shall
be fully protected in relying upon, (1) an Opinion of Counsel or reliance letter and (2) an Officer’s Certificate stating that
all conditions precedent to the execution, authentication and delivery of such Securities are in conformity with the provisions of this
Indenture.
The Trustee shall not be
required to authenticate such Securities if the issue of such Securities pursuant to this Indenture will affect the Trustee’s own
rights, duties or immunities under the Securities and this Indenture or otherwise in a manner that is not reasonably acceptable to the
Trustee.
Section
2.05 Registration of Transfer and Exchange.
(a)
Securities of any series may be exchanged upon presentation thereof at the office or agency of the Company designated for
such purpose, for other Securities of such series of authorized denominations, and for a like aggregate principal amount, upon payment
of a sum sufficient to cover any tax or other governmental charge in relation thereto, all as provided in this Section. In respect of
any Securities so surrendered for exchange, the Company shall execute, the Trustee shall authenticate and such office or agency shall
deliver in exchange therefor the Security or Securities of the same series that the Securityholder making the exchange shall be entitled
to receive, bearing numbers not contemporaneously outstanding.
(b)
The Company shall keep, or cause to be kept, at its office or agency designated for such purpose a register or registers (herein
referred to as the “Security Register”) in which, subject to such reasonable regulations as it may prescribe, the Company
shall register the Securities and the transfers of Securities as in this Article provided and which at all reasonable times shall be
open for inspection by the Trustee. The registrar for the purpose of registering Securities and transfer of Securities as herein provided
shall be appointed as authorized by Board Resolution or Supplemental Indenture (the “Security Registrar”).
Upon surrender for transfer
of any Security at the office or agency of the Company designated for such purpose, the Company shall execute, the Trustee shall authenticate
and such office or agency shall deliver in the name of the transferee or transferees a new Security or Securities of the same series
as the Security presented for a like aggregate principal amount.
The Company initially appoints
the Trustee as Security Registrar for each series of Securities.
All Securities presented
or surrendered for exchange or registration of transfer, as provided in this Section, shall be accompanied (if so required by the Company
or the Security Registrar) by a written instrument or instruments of transfer, in form satisfactory to the Company or the Security Registrar,
duly executed by the registered holder or by such holder’s duly authorized attorney in writing.
(c)
Except as provided pursuant to Section 2.01 pursuant to a Board Resolution, and set forth in an Officer’s Certificate,
or established in one or more indentures supplemental to this Indenture, no service charge shall be made for any exchange or registration
of transfer of Securities, or issue of new Securities in case of partial redemption of any series or repurchase, conversion or exchange
of less than the entire principal amount of a Security, but the Company may require payment of a sum sufficient to cover any tax or other
governmental charge in relation thereto, other than exchanges pursuant to Section 2.06, Section 3.03(b) and Section 9.04 not involving
any transfer.
(d)
The Company and the Security Registrar shall not be required (i) to issue, exchange or register the transfer of any Securities
during a period beginning at the opening of business 15 days before the day of the sending of a notice of redemption of less than all
the Outstanding Securities of the same series and ending at the close of business on the day of such sending, nor (ii) to register the
transfer of or exchange any Securities of any series or portions thereof called for redemption or surrendered for repurchase, but not
validly withdrawn, other than the unredeemed portion of any such Securities being redeemed in part or not surrendered for repurchase,
as the case may be. The provisions of this Section 2.05 are, with respect to any Global Security, subject to Section 2.11 hereof.
The Trustee shall have no
obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed under this Indenture or
under applicable law with respect to any transfer of any interest in any Security (including any transfers between or among Depositary
participants or beneficial owners of interests in any Global Security) other than to require delivery of such certificates and other
documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture,
and to examine the same to determine substantial compliance as to form with the express requirements hereof.
Section
2.06 Temporary Securities.
Pending the preparation of
definitive Securities of any series, the Company may execute, and the Trustee shall authenticate and deliver, temporary Securities (printed,
lithographed or typewritten) of any authorized denomination. Such temporary Securities shall be substantially in the form of the definitive
Securities in lieu of which they are issued, but with such omissions, insertions and variations as may be appropriate for temporary Securities,
all as may be determined by the Company. Every temporary Security of any series shall be executed by the Company and be authenticated
by the Trustee upon the same conditions and in substantially the same manner, and with like effect, as the definitive Securities of such
series. Without unnecessary delay the Company will execute and will furnish definitive Securities of such series and thereupon any or
all temporary Securities of such series may be surrendered in exchange therefor (without charge to the Securityholders), at the office
or agency of the Company designated for the purpose, and the Trustee shall authenticate and such office or agency shall deliver in exchange
for such temporary Securities an equal aggregate principal amount of definitive Securities of such series, unless the Company advises
the Trustee to the effect that definitive Securities need not be executed and furnished until further notice from the Company. Until
so exchanged, the temporary Securities of such series shall be entitled to the same benefits under this Indenture as definitive Securities
of such series authenticated and delivered hereunder.
Section
2.07 Mutilated, Destroyed, Lost or Stolen Securities.
In case any temporary or
definitive Security shall become mutilated or be destroyed, lost or stolen, the Company (subject to the next succeeding sentence) shall
execute, and upon the Company’s request the Trustee (subject as aforesaid) shall authenticate and deliver, a new Security of the
same series, bearing a number not contemporaneously outstanding, in exchange and substitution for the mutilated Security, or in lieu
of and in substitution for the Security so destroyed, lost or stolen. In every case the applicant for a substituted Security shall furnish
to the Company and the Trustee such security or indemnity as may be required by them to save each of them harmless, and, in every case
of destruction, loss or theft, the applicant shall also furnish to the Company and the Trustee evidence to their satisfaction of the
destruction, loss or theft of the applicant’s Security and of the ownership thereof. The Trustee may authenticate any such substituted
Security and deliver the same upon the written request or authorization of any officer of the Company. Upon the issuance of any substituted
Security, the Company may require the payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in
relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith.
In case any Security that
has matured or is about to mature shall become mutilated or be destroyed, lost or stolen, the Company may, instead of issuing a substitute
Security, pay or authorize the payment of the same (without surrender thereof except in the case of a mutilated Security) if the applicant
for such payment shall furnish to the Company and the Trustee such security or indemnity as they may require to save them harmless, and,
in case of destruction, loss or theft, evidence to the satisfaction of the Company and the Trustee of the destruction, loss or theft
of such Security and of the ownership thereof.
Every replacement Security
issued pursuant to the provisions of this Section shall constitute an additional contractual obligation of the Company whether or not
the mutilated, destroyed, lost or stolen Security shall be found at any time, or be enforceable by anyone, and shall be entitled to all
the benefits of this Indenture equally and proportionately with any and all other Securities of the same series duly issued hereunder.
All Securities shall be held and owned upon the express condition that the foregoing provisions are exclusive with respect to the replacement
or payment of mutilated, destroyed, lost or stolen Securities, and shall preclude (to the extent lawful) any and all other rights or
remedies, notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment
of negotiable instruments or other securities without their surrender.
Section
2.08 Cancellation.
All Securities surrendered
for the purpose of payment, redemption, repurchase, exchange, registration of transfer or conversion shall, if surrendered to the Company
or any paying agent (or any other applicable agent), be delivered to the Trustee for cancellation, or, if surrendered to the Trustee,
shall be cancelled by it, and no Securities shall be issued in lieu thereof except as expressly required or permitted by any of the provisions
of this Indenture. On request of the Company at the time of such surrender, the Trustee shall deliver to the Company canceled Securities
held by the Trustee. In the absence of such request the Trustee may dispose of canceled Securities in accordance with its standard procedures
and deliver a certificate of disposition to the Company. If the Company shall otherwise acquire any of the Securities, however, such
acquisition shall not operate as a redemption or satisfaction of the indebtedness represented by such Securities unless and until the
same are delivered to the Trustee for cancellation.
Section
2.09 Benefits of Indenture.
Nothing in this Indenture
or in the Securities, express or implied, shall give or be construed to give to any Person, other than the parties hereto and the holders
of the Securities any legal or equitable right, remedy or claim under or in respect of this Indenture, or under any covenant, condition
or provision herein contained; all such covenants, conditions and provisions being for the sole benefit of the parties hereto and of
the holders of the Securities.
Section
2.10 Authenticating Agent.
So long as any of the Securities
of any series remain Outstanding there may be an Authenticating Agent for any or all such series of Securities which the Trustee shall
have the right to appoint. Said Authenticating Agent shall be authorized to act on behalf of the Trustee to authenticate Securities of
such series issued upon exchange, transfer or partial redemption, repurchase or conversion thereof, and Securities so authenticated shall
be entitled to the benefits of this Indenture and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder.
All references in this Indenture to the authentication of Securities by the Trustee shall be deemed to include authentication by an Authenticating
Agent for such series. Each Authenticating Agent shall be acceptable to the Company and shall be a corporation that has a combined capital
and surplus, as most recently reported or determined by it, sufficient under the laws of any jurisdiction under which it is organized
or in which it is doing business to conduct a trust business, and that is otherwise authorized under such laws to conduct such business
and is subject to supervision or examination by federal or state authorities. If at any time any Authenticating Agent shall cease to
be eligible in accordance with these provisions, it shall resign immediately.
Any Authenticating Agent
may at any time resign by giving written notice of resignation to the Trustee and to the Company. The Trustee may at any time (and upon
request by the Company shall) terminate the agency of any Authenticating Agent by giving written notice of termination to such Authenticating
Agent and to the Company. Upon resignation, termination or cessation of eligibility of any Authenticating Agent, the Trustee may appoint
an eligible successor Authenticating Agent acceptable to the Company. Any successor Authenticating Agent, upon acceptance of its appointment
hereunder, shall become vested with all the rights, powers and duties of its predecessor hereunder as if originally named as an Authenticating
Agent pursuant hereto.
Section
2.11 Global Securities.
(a)
If the Company shall establish pursuant to Section 2.01 that the Securities of a particular series are to be issued as a Global
Security, then the Company shall execute and the Trustee shall, in accordance with Section 2.04, authenticate and deliver, a Global Security
that (i) shall represent, and shall be denominated in an amount equal to the aggregate principal amount of, all of the Outstanding Securities
of such series, (ii) shall be registered in the name of the Depositary or its nominee, (iii) shall be delivered by the Trustee to the
Depositary or pursuant to the Depositary’s instruction (or if the Depositary names the Trustee as its custodian, retained by the
Trustee), and (iv) shall bear a legend substantially to the following effect: “Except as otherwise provided in Section 2.11 of
the Indenture, this Security may be transferred, in whole but not in part, only to another nominee of the Depositary or to a successor
Depositary or to a nominee of such successor Depositary.”
(b) Notwithstanding the provisions of Section 2.05, the Global Security of a series may be transferred, in whole but not in part
and in the manner provided in Section 2.05, only to another nominee of the Depositary for such series, or to a successor Depositary for
such series selected or approved by the Company or to a nominee of such successor Depositary.
(c)
If at any time the Depositary for a series of the Securities notifies the Company that it is unwilling or unable to continue
as Depositary for such series or if at any time the Depositary for such series shall no longer be registered or in good standing under
the Exchange Act, or other applicable statute or regulation, and a successor Depositary for such series is not appointed by the Company
within 90 days after the Company receives such notice or becomes aware of such condition, as the case may be, or if an Event of Default
has occurred and is continuing and the Company has received a request from the Depositary or from the Trustee, this Section 2.11 shall
no longer be applicable to the Securities of such series and the Company will execute, and subject to Section 2.04, the Trustee will
authenticate and deliver the Securities of such series in definitive registered form without coupons, in authorized denominations, and
in an aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global Security.
In addition, the Company may at any time determine that the Securities of any series shall no longer be represented by a Global Security
and that the provisions of this Section 2.11 shall no longer apply to the Securities of such series. In such event the Company will execute
and, subject to Section 2.04, the Trustee, upon receipt of an Officer’s Certificate evidencing such determination by the Company,
will authenticate and deliver the Securities of such series in definitive registered form without coupons, in authorized denominations,
and in an aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global
Security. Upon the exchange of the Global Security for such Securities in definitive registered form without coupons, in authorized denominations,
the Global Security shall be canceled by the Trustee. Such Securities in definitive registered form issued in exchange for the Global
Security pursuant to this Section 2.11(c) shall be registered in such names and in such authorized denominations as the Depositary, pursuant
to instructions from its direct or indirect participants or otherwise, shall instruct the Trustee. The Trustee shall deliver such Securities
to the Depositary for delivery to the Persons in whose names such Securities are so registered.
Section
2.12 CUSIP Numbers.
The Company in issuing the
Securities may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP” numbers
in notices of redemption as a convenience to Securityholders; provided that any such notice may state that no representation is made
as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance
may be placed only on the other elements of identification printed on the Securities, and any such redemption shall not be affected by
any defect in or omission of such numbers. The Company will promptly notify the Trustee of any change in the “CUSIP” numbers.
article
3
REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS
Section
3.01 Redemption.
The Company may redeem the
Securities of any series issued hereunder on and after the dates and in accordance with the terms established for such series pursuant
to Section 2.01 hereof.
Section
3.02 Notice of Redemption.
(a)
In case the Company shall desire to exercise such right to redeem all or, as the case may be, a portion of the Securities
of any series in accordance with any right the Company reserved for itself to do so pursuant to Section 2.01 hereof, the Company
shall, or shall cause the Trustee to, give notice of such redemption to holders of the Securities of such series to be redeemed by mailing
(or with regard to any Global Security held in book entry form, by electronic mail in accordance with the applicable procedures of the
Depositary), a notice of such redemption not less than 30 days and not more than 90 days before the date fixed for redemption of that
series to such Securityholders at their last addresses as they shall appear upon the Security Register, unless a shorter period is specified
in the Securities to be redeemed. Any notice that is mailed in the manner herein provided shall be conclusively presumed to have been
duly given, whether or not the registered holder receives the notice. In any case, failure duly to give such notice to the holder of
any Security of any series designated for redemption in whole or in part, or any defect in the notice, shall not affect the validity
of the proceedings for the redemption of any other Securities of such series or any other series. In the case of any redemption of Securities
prior to the expiration of any restriction on such redemption provided in the terms of such Securities or elsewhere in this Indenture,
the Company shall furnish the Trustee with an Officer’s Certificate evidencing compliance with any such restriction.
Each such notice of redemption
shall identify the Securities to be redeemed (including CUSIP numbers, if any), specify the date fixed for redemption and the redemption
price at which Securities of that series are to be redeemed, and shall state that payment of the redemption price of such Securities
to be redeemed will be made at the office or agency of the Company, upon presentation and surrender of such Securities, that interest
accrued to the date fixed for redemption will be paid as specified in said notice, that from and after said date interest will cease
to accrue and that the redemption is from a sinking fund, if such is the case. If less than all the Securities of a series are to be
redeemed, the notice to the holders of Securities of that series to be redeemed in part shall specify the particular Securities to be
so redeemed.
In case any Security is to
be redeemed in part only, the notice that relates to such Security shall state the portion of the principal amount thereof to be redeemed,
and shall state that on and after the redemption date, upon surrender of such Security, a new Security or Securities of such series in
principal amount equal to the unredeemed portion thereof will be issued.
(b)
If less than all the Securities of a series are to be redeemed, the Company shall give the Trustee at least 45 days’
notice (unless a shorter notice shall be satisfactory to the Trustee) in advance of the date fixed for redemption as to the aggregate
principal amount of Securities of the series to be redeemed, and thereupon the Securities to be redeemed shall be selected, by lot, on
a pro rata basis, or in such other manner as the Company shall deem appropriate and fair in its discretion and that may provide for the
selection of a portion or portions (equal to one thousand U.S. dollars ($1,000) or any integral multiple thereof) of the principal amount
of such Securities of a denomination larger than $1,000, the Securities to be redeemed and shall thereafter promptly notify the Company
in writing of the numbers of the Securities to be redeemed, in whole or in part. The Company may, if and whenever it shall so elect,
by delivery of instructions signed on its behalf by an Officer, instruct the Trustee or any paying agent to call all or any part of the
Securities of a particular series for redemption and to give notice of redemption in the manner set forth in this Section, such notice
to be in the name of the Company or its own name as the Trustee or such paying agent may deem advisable. In any case in which notice
of redemption is to be given by the Trustee or any such paying agent, the Company shall deliver or cause to be delivered to, or permit
to remain with, the Trustee or such paying agent, as the case may be, such Security Register, transfer books or other records, or suitable
copies or extracts therefrom, sufficient to enable the Trustee or such paying agent to give any notice by mail that may be required under
the provisions of this Section.
Section
3.03 Payment Upon Redemption.
(a)
If the giving of notice of redemption shall have been completed as above provided, the Securities or portions of Securities
of the series to be redeemed specified in such notice shall become due and payable on the date and at the place stated in such notice
at the applicable redemption price, together with interest accrued to, but excluding, the date fixed for redemption and interest on such
Securities or portions of Securities shall cease to accrue on and after the date fixed for redemption, unless the Company shall default
in the payment of such redemption price and accrued interest with respect to any such Security or portion thereof. On presentation and
surrender of such Securities on or after the date fixed for redemption at the place of payment specified in the notice, said Securities
shall be paid and redeemed at the applicable redemption price for such series, together with interest accrued thereon to, but excluding,
the date fixed for redemption (but if the date fixed for redemption is an Interest Payment Date, the interest installment payable on
such date shall be payable to the registered holder at the close of business on the applicable record date pursuant to Section 2.03).
(b) Upon
presentation of any Security of such series that is to be redeemed in part only, the Company shall execute and the Trustee shall authenticate
and the office or agency where the Security is presented shall deliver to the Securityholder thereof, at the expense of the Company,
a new Security of the same series of authorized denominations in principal amount equal to the unredeemed portion of the Security so
presented.
Section
3.04 Sinking Fund.
The provisions of Sections
3.04, 3.05 and 3.06 shall be applicable to any sinking fund for the retirement of Securities of a series, except as otherwise specified
as contemplated by Section 2.01 for Securities of such series.
The minimum amount of any
sinking fund payment provided for by the terms of Securities of any series is herein referred to as a “mandatory sinking fund payment,”
and any payment in excess of such minimum amount provided for by the terms of Securities of any series is herein referred to as an “optional
sinking fund payment”. If provided for by the terms of Securities of any series, the cash amount of any sinking fund payment may
be subject to reduction as provided in Section 3.05. Each sinking fund payment shall be applied to the redemption of Securities of any
series as provided for by the terms of Securities of such series.
Section
3.05 Satisfaction of Sinking Fund Payments with Securities.
The Company (i) may deliver
Outstanding Securities of a series and (ii) may apply as a credit Securities of a series that have been redeemed either at the election
of the Company pursuant to the terms of such Securities or through the application of permitted optional sinking fund payments pursuant
to the terms of such Securities, in each case in satisfaction of all or any part of any sinking fund payment with respect to the Securities
of such series required to be made pursuant to the terms of such Securities as provided for by the terms of such series, provided that
such Securities have not been previously so credited. Such Securities shall be received and credited for such purpose by the Trustee
at the redemption price specified in such Securities for redemption through operation of the sinking fund and the amount of such sinking
fund payment shall be reduced accordingly.
Section
3.06 Redemption of Securities for Sinking Fund.
Not less than 45 days prior
to each sinking fund payment date for any series of Securities (unless a shorter period shall be satisfactory to the Trustee), the Company
will deliver to the Trustee an Officer’s Certificate specifying the amount of the next ensuing sinking fund payment for that series
pursuant to the terms of the series, the portion thereof, if any, that is to be satisfied by delivering and crediting Securities of that
series pursuant to Section 3.05 and the basis for such credit and will, together with such Officer’s Certificate, deliver to the
Trustee any Securities to be so delivered. Not less than 30 days before each such sinking fund payment date the Securities to be redeemed
upon such sinking fund payment date shall be selected in the manner specified in Section 3.02 and the Company shall cause notice of the
redemption thereof to be given in the name of and at the expense of the Company in the manner provided in Section 3.02. Such notice having
been duly given, the redemption of such Securities shall be made upon the terms and in the manner stated in Section 3.03.
article
4
COVENANTS
Section
4.01 Payment of Principal, Premium and Interest.
The Company will duly and
punctually pay or cause to be paid the principal of (and premium, if any) and interest on the Securities of that series at the time and
place and in the manner provided herein and established with respect to such Securities. Payments of principal on the Securities may
be made at the time provided herein and established with respect to such Securities by U.S. dollar check drawn on and mailed to the address
of the Securityholder entitled thereto as such address shall appear in the Security Register, or U.S. dollar wire transfer to, a U.S.
dollar account if such Securityholder shall have furnished wire instructions to the Trustee no later than 15 days prior to the relevant
payment date. Payments of interest on the Securities may be made at the time provided herein and established with respect to such Securities
by U.S. dollar check mailed to the address of the Securityholder entitled thereto as such address shall appear in the Security Register,
or U.S. dollar wire transfer to, a U.S. dollar account if such Securityholder shall have furnished wire instructions in writing to the
Security Registrar and the Trustee no later than 15 days prior to the relevant payment date.
Section
4.02 Maintenance of Office or Agency.
So long as any series of
the Securities remain Outstanding, the Company agrees to maintain an office or agency with respect to each such series and at such other
location or locations as may be designated as provided in this Section 4.02, where (i) Securities of that series may be presented for
payment, (ii) Securities of that series may be presented as herein above authorized for registration of transfer and exchange, and (iii)
notices and demands to or upon the Company in respect of the Securities of that series and this Indenture may be given or served, such
designation to continue with respect to such office or agency until the Company shall, by written notice signed by any officer authorized
to sign an Officer’s Certificate and delivered to the Trustee, designate some other office or agency for such purposes or any of
them. If at any time the Company shall fail to maintain any such required office or agency or shall fail to furnish the Trustee with
the address thereof, such presentations, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and
the Company hereby appoints the Trustee as its agent to receive all such presentations, notices and demands. The Company initially appoints
the Corporate Trust Office of the Trustee as its paying agent with respect to the Securities.
Section
4.03 Paying Agents.
(a)
If the Company shall appoint one or more paying agents for all or any series of the Securities, other than the Trustee, the
Company will cause each such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the
Trustee, subject to the provisions of this Section:
(1)
that it will hold all sums held by it as such agent for the payment of the principal of (and premium, if any) or interest
on the Securities of that series (whether such sums have been paid to it by the Company or by any other obligor of such Securities) in
trust for the benefit of the Persons entitled thereto;
(2)
that it will give the Trustee notice of any failure by the Company (or by any other obligor of such Securities) to make any
payment of the principal of (and premium, if any) or interest on the Securities of that series when the same shall be due and payable;
(3)
that it will, at any time during the continuance of any failure referred to in the preceding paragraph (a)(2) above, upon
the written request of the Trustee, forthwith pay to the Trustee all sums so held in trust by such paying agent; and
(4)
that it will perform all other duties of paying agent as set forth in this Indenture.
(b)
If the Company shall act as its own paying agent with respect to any series of the Securities, it will on or before each due
date of the principal of (and premium, if any) or interest on Securities of that series, set aside, segregate and hold in trust for the
benefit of the Persons entitled thereto a sum sufficient to pay such principal (and premium, if any) or interest so becoming due on Securities
of that series until such sums shall be paid to such Persons or otherwise disposed of as herein provided and will promptly notify the
Trustee of such action, or any failure (by it or any other obligor on such Securities) to take such action. Whenever the Company shall
have one or more paying agents for any series of Securities, it will, prior to each due date of the principal of (and premium, if any)
or interest on any Securities of that series, deposit with the paying agent a sum sufficient to pay the principal (and premium, if any)
or interest so becoming due, such sum to be held in trust for the benefit of the Persons entitled to such principal, premium or interest,
and (unless such paying agent is the Trustee) the Company will promptly notify the Trustee of this action or failure so to act.
(c)
Notwithstanding anything in this Section to the contrary, (i) the agreement to hold sums in trust as provided in this Section
is subject to the provisions of Section 11.05, and (ii) the Company may at any time, for the purpose of obtaining the satisfaction and
discharge of this Indenture or for any other purpose, pay, or direct any paying agent to pay, to the Trustee all sums held in trust by
the Company or such paying agent, such sums to be held by the Trustee upon the same terms and conditions as those upon which such sums
were held by the Company or such paying agent; and, upon such payment by the Company or any paying agent to the Trustee, the Company
or such paying agent shall be released from all further liability with respect to such money.
Section
4.04 Appointment to Fill Vacancy in Office of Trustee.
The Company, whenever necessary
to avoid or fill a vacancy in the office of Trustee, will appoint, in the manner provided in Section 7.10, a Trustee, so that there shall
at all times be a Trustee hereunder.
article
5
SECURITYHOLDERS’ LISTS AND REPORTS BY THE COMPANY AND THE TRUSTEE
Section
5.01 Company to Furnish Trustee Names and Addresses of Securityholders.
The Company will furnish
or cause to be furnished to the Trustee (a) within 15 days after each regular record date (as defined in Section 2.03) a list, in such
form as the Trustee may reasonably require, of the names and addresses of the holders of each series of Securities as of such regular
record date, provided that the Company shall not be obligated to furnish or cause to furnish such list at any time that the list shall
not differ in any respect from the most recent list furnished to the Trustee by the Company and (b) at such other times as the Trustee
may request in writing within 30 days after the receipt by the Company of any such request, a list of similar form and content as of
a date not more than 15 days prior to the time such list is furnished; provided, however, that, in either case, no such list need be
furnished for any series for which the Trustee shall be the Security Registrar.
Section
5.02 Preservation Of Information; Communications With Securityholders.
(a)
The Trustee shall preserve, in as current a form as is reasonably practicable, all information as to the names and addresses
of the holders of Securities contained in the most recent list furnished to it as provided in Section 5.01 and as to the names and addresses
of holders of Securities received by the Trustee in its capacity as Security Registrar (if acting in such capacity).
(b) The Trustee may destroy any list furnished to it as provided in Section 5.01 upon receipt of a new list so furnished.
(c)
Securityholders may communicate as provided in Section 312(b) of the Trust Indenture Act with other Securityholders with respect
to their rights under this Indenture or under the Securities, and, in connection with any such communications, the Trustee shall satisfy
its obligations under Section 312(b) of the Trust Indenture Act in accordance with the provisions of Section 312(b) of the Trust Indenture
Act.
Section
5.03 Reports by the Company.
(a)
The Company will at all times comply with Section 314(a) of the Trust Indenture Act. The Company covenants and agrees to provide
(which delivery may be via electronic mail) to the Trustee within 30 days, after the Company files the same with the Commission, copies
of the annual reports and of the information, documents and other reports (or copies of such portions of any of the foregoing as the
Commission may from time to time by rules and regulations prescribe) that the Company is required to file with the Commission pursuant
to Section 13 or Section 15(d) of the Exchange Act; provided, however, the Company shall not be required to deliver to the Trustee any
correspondence filed with the Commission or any materials for which the Company has sought and received confidential treatment by the
Commission; and provided further, that so long as such filings by the Company are available on the Commission’s Electronic Data
Gathering, Analysis and Retrieval System (EDGAR), or any successor system, such filings shall be deemed to have been filed with the Trustee
for purposes hereof without any further action required by the Company. For the avoidance of doubt, a failure by the Company to file
annual reports, information and other reports with the Commission within the time period prescribed thereof by the Commission shall not
be deemed a breach of this Section 5.03.
(b) Delivery of reports, information and documents to the Trustee under Section 5.03 is for informational purposes only and the
information and the Trustee’s receipt of the foregoing shall not constitute constructive notice of any information contained therein,
or determinable from information contained therein including the Company’s compliance with any of their covenants thereunder (as
to which the Trustee is entitled to rely exclusively on an Officer’s Certificate). The Trustee is under no duty to examine any
such reports, information or documents delivered to the Trustee or filed with the Commission via EDGAR to ensure compliance with the
provision of this Indenture or to ascertain the correctness or otherwise of the information or the statements contained therein. The
Trustee shall have no responsibility or duty whatsoever to ascertain or determine whether the above referenced filings with the Commission
on EDGAR (or any successor system) has occurred.
Section
5.04 Reports by the Trustee.
(a)
If required by Section 313(a) of the Trust Indenture Act, the Trustee, within sixty (60) days after each May 1, shall send
to the Securityholders, as their names and addresses appear upon the Security Register, a brief report dated as of such May 1, which
complies with Section 313(a) of the Trust Indenture Act.
(b) The Trustee shall comply with Section 313(b) and 313(c) of the Trust Indenture Act.
(c)
A copy of each such report shall, at the time of such transmission to Securityholders, be filed by the Trustee with the Company,
with each securities exchange upon which any Securities are listed (if so listed) and also with the Commission. The Company agrees to
notify the Trustee when any Securities become listed on any securities exchange.
article
6
REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT
Section
6.01 Events of Default.
(a)
Whenever used herein with respect to Securities of a particular series, “Event of Default” means any one or more
of the following events that has occurred and is continuing:
(1)
the Company defaults in the payment of any installment of interest upon any of the Securities of that series, as and when
the same shall become due and payable, and such default continues for a period of 90 days; provided, however, that a valid extension
of an interest payment period by the Company in accordance with the terms of any indenture supplemental hereto shall not constitute a
default in the payment of interest for this purpose;
(2)
the Company defaults in the payment of the principal of (or premium, if any, on) any of the Securities of that series as and
when the same shall become due and payable whether at maturity, upon redemption, by declaration or otherwise, or in any payment required
by any sinking or analogous fund established with respect to that series; provided, however, that a valid extension of the maturity of
such Securities in accordance with the terms of any indenture supplemental hereto shall not constitute a default in the payment of principal
or premium, if any;
(3)
the Company fails to observe or perform any other of its covenants or agreements with respect to that series contained in
this Indenture or otherwise established with respect to that series of Securities pursuant to Section 2.01 hereof (other than a covenant
or agreement that has been expressly included in this Indenture solely for the benefit of one or more series of Securities other than
such series) for a period of 90 days after the date on which written notice of such failure, requiring the same to be remedied and stating
that such notice is a “Notice of Default” hereunder, shall have been given to the Company by the Trustee, by registered or
certified mail, or to the Company and the Trustee by the holders of at least 25% in principal amount of the Securities of that series
at the time Outstanding;
(4)
the Company pursuant to or within the meaning of any Insolvency Law (i) commences a voluntary case, (ii) consents to the entry
of an order for relief against it in an involuntary case, (iii) consents to the appointment of a Custodian of it or for all or substantially
all of its property or (iv) makes a general assignment for the benefit of its creditors; or
(5)
a court of competent jurisdiction enters an order under any Insolvency Law that (i) is for relief against the Company in an
involuntary case, (ii) appoints a Custodian of the Company for all or substantially all of its property or (iii) orders the liquidation
of the Company, and the order or decree remains unstayed and in effect for 90 days.
(b)
In each and every such case (other than an Event of Default specified in clause (4) or clause (5) above), unless the principal
of all the Securities of that series shall have already become due and payable, either the Trustee or the holders of not less than 25%
in aggregate principal amount of the Securities of that series then Outstanding hereunder, by notice in writing to the Company (and to
the Trustee if given by such Securityholders), may declare the principal of (and premium, if any, on) and accrued and unpaid interest
on all the Securities of that series to be due and payable immediately, and upon any such declaration the same shall become and shall
be immediately due and payable. If an Event of Default specified in clause (4) or clause (5) above occurs, the principal of and accrued
and unpaid interest on all the Securities of that series shall automatically be immediately due and payable without any declaration or
other act on the part of the Trustee or the holders of the Securities.
(c)
At any time after the principal of (and premium, if any, on) and accrued and unpaid interest on the Securities of that series
shall have been so declared due and payable, and before any judgment or decree for the payment of the moneys due shall have been obtained
or entered as hereinafter provided, the holders of a majority in aggregate principal amount of the Securities of that series then Outstanding
hereunder, by written notice to the Company and the Trustee, may rescind and annul such declaration and its consequences if: (i) the
Company has paid or deposited with the Trustee a sum sufficient to pay all matured installments of interest upon all the Securities of
that series and the principal of (and premium, if any, on) any and all Securities of that series that shall have become due otherwise
than by acceleration (with interest upon such principal and premium, if any, and, to the extent that such payment is enforceable under
applicable law, upon overdue installments of interest, at the rate per annum expressed in the Securities of that series to the date of
such payment or deposit) and the amount payable to the Trustee under Section 7.06, and (ii) any and all Events of Default under the Indenture
with respect to such series, other than the nonpayment of principal on (and premium, if any, on) and accrued and unpaid interest on Securities
of that series that shall not have become due by their terms, shall have been remedied or waived as provided in Section 6.06.
No such rescission and annulment
shall extend to or shall affect any subsequent default or impair any right consequent thereon.
(d)
In case the Trustee shall have proceeded to enforce any right with respect to Securities of that series under this Indenture
and such proceedings shall have been discontinued or abandoned because of such rescission or annulment or for any other reason or shall
have been determined adversely to the Trustee, then and in every such case, subject to any determination in such proceedings, the Company
and the Trustee shall be restored respectively to their former positions and rights hereunder, and all rights, remedies and powers of
the Company and the Trustee shall continue as though no such proceedings had been taken.
Section
6.02 Collection of Indebtedness and Suits for Enforcement by Trustee.
(a)
The Company covenants that (i) in case it shall default in the payment of any installment of interest on any of the Securities
of a series, or in any payment required by any sinking or analogous fund established with respect to that series as and when the same
shall have become due and payable, and such default shall have continued for a period of 90 days, or (ii) in case it shall default
in the payment of the principal of (or premium, if any, on) any of the Securities of a series when the same shall have become due and
payable, whether upon maturity of the Securities of a series or upon redemption or upon declaration or otherwise then, upon demand of
the Trustee, the Company will pay to the Trustee, for the benefit of the holders of the Securities of that series, the whole amount that
then shall have been become due and payable on all such Securities for principal (and premium, if any) or interest, or both, as the case
may be, with interest upon the overdue principal (and premium, if any) and (to the extent that payment of such interest is enforceable
under applicable law) upon overdue installments of interest at the rate per annum expressed in the Securities of that series; and, in
addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, and the amount payable to
the Trustee under Section 7.06.
(b)
If the Company shall fail to pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an
express trust, shall be entitled and empowered to institute any action or proceedings at law or in equity for the collection of the sums
so due and unpaid, and may prosecute any such action or proceeding to judgment or final decree, and may enforce any such judgment or
final decree against the Company or other obligor upon the Securities of that series and collect the moneys adjudged or decreed to be
payable in the manner provided by law or equity out of the property of the Company or other obligor upon the Securities of that series,
wherever situated.
(c)
In case of any receivership, insolvency, liquidation, bankruptcy, reorganization, readjustment, arrangement, composition or
judicial proceedings affecting the Company, or its creditors or property, the Trustee shall have power to intervene in such proceedings
and take any action therein that may be permitted by the court and shall (except as may be otherwise provided by law) be entitled to
file such proofs of claim and other papers and documents as may be necessary or advisable in order to have the claims of the Trustee
and of the holders of Securities of such series allowed for the entire amount due and payable by the Company under the Indenture at the
date of institution of such proceedings and for any additional amount that may become due and payable by the Company after such date,
and to collect and receive any moneys or other property payable or deliverable on any such claim, and to distribute the same after the
deduction of the amount payable to the Trustee under Section 7.06; and any receiver, assignee or trustee in bankruptcy or reorganization
is hereby authorized by each of the holders of Securities of such series to make such payments to the Trustee, and, in the event that
the Trustee shall consent to the making of such payments directly to such Securityholders, to pay to the Trustee any amount due it under
Section 7.06.
(d)
All rights of action and of asserting claims under this Indenture, or under any of the terms established with respect to Securities
of that series, may be enforced by the Trustee without the possession of any of such Securities, or the production thereof at any trial
or other proceeding relative thereto, and any such suit or proceeding instituted by the Trustee shall be brought in its own name as trustee
of an express trust, and any recovery of judgment shall, after provision for payment to the Trustee of any amounts due under Section
7.06, be for the ratable benefit of the holders of the Securities of such series.
In case of an Event of Default
hereunder, the Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate
judicial proceedings as the Trustee shall deem most effectual to protect and enforce any of such rights, either at law or in equity or
in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in the Indenture or in aid of
the exercise of any power granted in this Indenture, or to enforce any other legal or equitable right vested in the Trustee by this Indenture
or by law.
Nothing contained herein
shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Securityholder any plan of reorganization,
arrangement, adjustment or composition affecting the Securities of that series or the rights of any Securityholder thereof or to authorize
the Trustee to vote in respect of the claim of any Securityholder in any such proceeding.
Section
6.03 Application of Moneys Collected.
Any moneys collected by the
Trustee pursuant to this Article with respect to a particular series of Securities shall be applied in the following order, at the date
or dates fixed by the Trustee and, in case of the distribution of such moneys on account of principal (or premium, if any) or interest,
upon presentation of the Securities of that series, and notation thereon of the payment, if only partially paid, and upon surrender thereof
if fully paid:
FIRST: To the payment of
costs and expenses of collection and of all amounts payable to the Trustee under Section 7.06;
SECOND: To the payment of
the amounts then due and unpaid upon Securities of such series for principal (and premium, if any) and interest, in respect of which
or for the benefit of which such money has been collected, ratably, without preference or priority of any kind, according to the amounts
due and payable on such Securities for principal (and premium, if any) and interest, respectively; and
THIRD: To the payment of
the remainder, if any, to the Company or any other Person lawfully entitled thereto.
Section
6.04 Limitation on Suits.
No holder of any Security
of any series shall have any right by virtue or by availing of any provision of this Indenture to institute any suit, action or proceeding
in equity or at law upon or under or with respect to this Indenture or for the appointment of a receiver or trustee, or for any other
remedy hereunder, unless (i) such Securityholder previously shall have given to the Trustee written notice of an Event of Default and
of the continuance thereof with respect to the Securities of such series specifying such Event of Default, as hereinbefore provided;
(ii) the holders of not less than 25% in aggregate principal amount of the Securities of such series then Outstanding shall have made
written request upon the Trustee to institute such action, suit or proceeding in its own name as Trustee hereunder; (iii) such Securityholder
or Securityholders shall have offered to the Trustee indemnity satisfactory to it against the costs, expenses and liabilities to be incurred
in compliance with such request; (iv) the Trustee for 90 days after its receipt of such notice, request and offer of indemnity, shall
have failed to institute any such action, suit or proceeding and (v) during such 90 day period, the holders of a majority in principal
amount of the Securities of that series do not give the Trustee a direction inconsistent with the request.
Notwithstanding anything
contained herein to the contrary or any other provisions of this Indenture, the right of any holder of any Security to receive payment
of the principal of (and premium, if any) and interest on such Security, as therein provided, on or after the respective due dates expressed
in such Security (or in the case of redemption, on the redemption date), or to institute suit for the enforcement of any such payment
on or after such respective dates or redemption date, shall not be impaired or affected without the consent of such holder and by accepting
a Security hereunder it is expressly understood, intended and covenanted by the taker and holder of every Security of such series with
every other such taker and holder and the Trustee, that no one or more holders of Securities of such series shall have any right in any
manner whatsoever by virtue or by availing of any provision of this Indenture to affect, disturb or prejudice the rights of the holders
of any other of such Securities, or to obtain or seek to obtain priority over or preference to any other such holder, or to enforce any
right under this Indenture, except in the manner herein provided and for the equal, ratable and common benefit of all holders of Securities
of such series. For the protection and enforcement of the provisions of this Section, each and every Securityholder and the Trustee shall
be entitled to such relief as can be given either at law or in equity.
Section
6.05 Rights and Remedies Cumulative; Delay or Omission Not Waiver.
(a)
Except as otherwise provided in Section 2.07, all powers and remedies given by this Article to the Trustee or to the Securityholders
shall, to the extent permitted by law, be deemed cumulative and not exclusive of any other powers and remedies available to the Trustee
or the holders of the Securities, by judicial proceedings or otherwise, to enforce the performance or observance of the covenants and
agreements contained in this Indenture or otherwise established with respect to such Securities.
(b)
No delay or omission of the Trustee or of any holder of any of the Securities to exercise any right or power accruing upon
any Event of Default occurring and continuing as aforesaid shall impair any such right or power, or shall be construed to be a waiver
of any such default or an acquiescence therein; and, subject to the provisions of Section 6.04, every power and remedy given by this
Article or by law to the Trustee or the Securityholders may be exercised from time to time, and as often as shall be deemed expedient,
by the Trustee or by the Securityholders.
Section
6.06 Control by Securityholders.
The holders of a majority
in aggregate principal amount of the Securities of any series at the time Outstanding, determined in accordance with Section 8.04, shall
have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising
any trust or power conferred on the Trustee with respect to such series; provided, however, that such direction shall not be in conflict
with any rule of law or with this Indenture or subject the Trustee in its sole discretion to personal liability. Subject to the provisions
of Section 7.01, the Trustee shall have the right to decline to follow any such direction if the Trustee in good faith shall, by a Responsible
Officer or officers of the Trustee, determine that the proceeding so directed, subject to the Trustee’s duties under the Trust
Indenture Act, would involve the Trustee in personal liability or might be unduly prejudicial to the Securityholders not involved in
the proceeding. The holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding affected
thereby, determined in accordance with Section 8.04, may on behalf of the holders of all of the Securities of such series waive any past
default in the performance of any of the covenants contained herein or established pursuant to Section 2.01 with respect to such series
and its consequences, except a default in the payment of the principal of, or premium, if any, or interest on, any of the Securities
of that series as and when the same shall become due by the terms of such Securities otherwise than by acceleration (unless such default
has been cured and a sum sufficient to pay all matured installments of interest and principal and any premium has been deposited with
the Trustee (in accordance with Section 6.01(c)). Upon any such waiver, the default covered thereby shall be deemed to be cured for all
purposes of this Indenture and the Company, the Trustee and the holders of the Securities of such series shall be restored to their former
positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent or other default or impair any right
consequent thereon.
Section
6.07 Undertaking to Pay Costs.
All parties to this Indenture
agree, and each holder of any Securities by such holder’s acceptance thereof shall be deemed to have agreed, that any court may
in its discretion require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee
for any action taken or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of
such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees and expenses,
against any party litigant in such suit, having due regard to the merits and good faith of the claims or defenses made by such party
litigant; but the provisions of this Section shall not apply to any suit instituted by the Trustee, to any suit instituted by any Securityholder,
or group of Securityholders, holding more than 10% in aggregate principal amount of the Outstanding Securities of any series, or to any
suit instituted by any Securityholder for the enforcement of the payment of the principal of (or premium, if any) or interest on any
Security of such series, on or after the respective due dates expressed in such Security or established pursuant to this Indenture.
article
7
CONCERNING THE TRUSTEE
Section
7.01 Certain Duties and Responsibilities of Trustee.
(a)
The Trustee, prior to the occurrence of an Event of Default with respect to the Securities of a series and after the curing
of all Events of Default with respect to the Securities of that series that may have occurred, shall undertake to perform with respect
to the Securities of such series such duties and only such duties as are specifically set forth in this Indenture, and no implied covenants
shall be read into this Indenture against the Trustee. In case an Event of Default with respect to the Securities of a series has occurred
(that has not been cured or waived), the Trustee shall exercise with respect to Securities of that series such of the rights and powers
vested in it by this Indenture, and use the same degree of care and skill in their exercise, as a prudent man would exercise or use under
the circumstances in the conduct of his or her own affairs.
(b) No provision of this Indenture shall be construed to relieve the Trustee from liability for its own negligent action, its
own negligent failure to act, or its own willful misconduct, except that:
(i) prior to the occurrence of an Event of Default with respect to the Securities of a series and after the curing or waiving
of all such Events of Default with respect to that series that may have occurred:
(A) the duties and obligations of the Trustee shall with respect to the Securities of such series be determined solely by the
express provisions of this Indenture, and the Trustee shall not be liable with respect to the Securities of such series except for the
performance of such duties and obligations as are specifically set forth in this Indenture, and no implied covenants or obligations shall
be read into this Indenture against the Trustee; and
(B) in the absence of bad faith on the part of the Trustee, the Trustee may with respect to the Securities of such series conclusively
rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any certificates or opinions furnished
to the Trustee and conforming to the requirements of this Indenture; but in the case of any such certificates or opinions that by any
provision hereof are specifically required to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine
whether or not they conform to the requirements of this Indenture;
(ii) the Trustee shall not be liable to any Securityholder or to any other Person for any error of judgment made in good faith
by a Responsible Officer or Responsible Officers of the Trustee, unless it shall be proved that the Trustee was negligent in ascertaining
the pertinent facts;
(iii) the
Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in accordance with the direction
of the holders of not less than a majority in principal amount of the Securities of any series at the time Outstanding relating to the
time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred
upon the Trustee under this Indenture with respect to the Securities of that series;
(iv)
none of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise
incur personal financial liability in the performance of any of its duties or in the exercise of any of its rights or powers if there
is reasonable ground for believing that the repayment of such funds or liability is not reasonably assured to it under the terms of this
Indenture or adequate indemnity against such risk is not reasonably assured to it;
(v)
The Trustee shall not be required to give any bond or surety in respect of the performance of its powers or duties hereunder;
(vi) The permissive right of the Trustee to do things enumerated in this Indenture shall not be construed as a duty of the Trustee;
and
(vii) No Trustee shall have any duty or responsibility for any act or omission of any other Trustee appointed with respect to a
series of Securities hereunder.
Section
7.02 Certain Rights of Trustee.
Except as otherwise provided
in Section 7.01:
(a)
The Trustee may conclusively rely and shall be protected in acting or refraining from acting upon any resolution, certificate,
statement, instrument, opinion, report, notice, request, consent, order, approval, bond, security or other paper or document believed
by it to be genuine and to have been signed or presented by the proper party or parties;
(b) Any
request, direction, order or demand of the Company mentioned herein shall be sufficiently evidenced by a Board Resolution or an
instrument signed in the name of the Company by any authorized Officer of the Company (unless other evidence in respect thereof is
specifically prescribed herein);
(c)
The Trustee may consult with counsel and the opinion or written advice of such counsel or, if requested, any Opinion of Counsel
shall be full and complete authorization and protection in respect of any action taken or suffered or omitted hereunder in good faith
and in reliance thereon;
(d) The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request,
order or direction of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders shall have
offered to the Trustee security or indemnity reasonably acceptable to the Trustee against the costs, expenses and liabilities that may
be incurred therein or thereby; nothing contained herein shall, however, relieve the Trustee of the obligation, upon the occurrence of
an Event of Default with respect to a series of the Securities (that has not been cured or waived), to exercise with respect to Securities
of that series such of the rights and powers vested in it by this Indenture, and to use the same degree of care and skill in their exercise,
as a prudent man would exercise or use under the circumstances in the conduct of his or her own affairs;
(e)
The Trustee shall not be liable for any action taken or omitted to be taken by it in good faith and believed by it to be authorized
or within the discretion or rights or powers conferred upon it by this Indenture;
(f)
The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate,
statement, instrument, opinion, report, notice, request, consent, order, approval, bond, security, or other papers or documents or inquire
as to the performance by the Company of one of its covenants under this Indenture, unless requested in writing so to do by the holders
of not less than a majority in principal amount of the Outstanding Securities of the particular series affected thereby (determined as
provided in Section 8.04); provided, however, that if the payment within a reasonable time to the Trustee of the costs, expenses or liabilities
likely to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee
by the security afforded to it by the terms of this Indenture, the Trustee may require security or indemnity reasonably acceptable to
the Trustee against such costs, expenses or liabilities as a condition to so proceeding. The reasonable expense of every such examination
shall be paid by the Company or, if paid by the Trustee, shall be repaid by the Company upon demand;
(g) The
Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents or
attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with
due care by it hereunder;
(h) In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations hereunder
arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages,
accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions,
loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee
shall use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable
under the circumstances;
(i) In no event shall the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of
any kind whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood
of such loss or damage and regardless of the form of action; and
(j)
The Trustee agrees to accept and act upon instructions or directions pursuant to this Indenture sent by unsecured e-mail,
facsimile transmission or other similar unsecured electronic methods; provided, however, that (a) the party providing such written
instructions, subsequent to such transmission of written instructions, shall provide the originally executed instructions or directions
to the Trustee in a timely manner, and (b) such originally executed instructions or directions shall be signed by an authorized
representative of the party providing such instructions or directions. If the party elects to give the Trustee e-mail or facsimile instructions
(or instructions by a similar electronic method) and the Trustee in its discretion elects to act upon such instructions, the Trustee’s
understanding of such instructions shall be deemed controlling. The Trustee shall not be liable for any losses, costs or expenses arising
directly or indirectly from the Trustee’s reliance upon and compliance with such instructions notwithstanding such instructions
conflict or are inconsistent with a subsequent written instruction. The party providing electronic instructions agrees to assume all
risks arising out of the use of such electronic methods to submit instructions and directions to the Trustee, including without limitation
the risk of the Trustee acting on unauthorized instructions, and the risk or interception and misuse by third parties. The Trustee may
request that the Company deliver an Officer’s Certificate setting forth the names of individuals and/or titles of officers authorized
at such time to furnish the Trustee with Officer’s Certificates, Company Orders and any other matters or directions pursuant to
this Indenture;
(k)
The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right
to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder and under the Securities,
and each agent, custodian or other person employed to act under this Indenture; and
(l)
The Trustee shall not be deemed to have knowledge of any Default or Event of Default (other than an Event of Default constituting
the failure to pay the interest on, or the principal of, the Securities if the Trustee also serves as the paying agent for such Securities)
until the Trustee shall have received written notification in the manner set forth in this Indenture or a Responsible Officer of the
Trustee shall have obtained actual knowledge.
Section
7.03 Trustee Not Responsible for Recitals or Issuance or Securities.
(a)
The recitals contained herein and in the Securities shall be taken as the statements of the Company, and the Trustee assumes
no responsibility for the correctness of the same. The Trustee shall not be responsible for any statement in any registration statement,
prospectus, or any other document in connection with the sale of Securities. The Trustee shall not be responsible for any rating on the
Securities or any action or omission of any rating agency.
(b) The Trustee makes no representations as to the validity or sufficiency of this Indenture or of the Securities.
(c)
The Trustee shall not be accountable for the use or application by the Company of any of the Securities or of the proceeds
of such Securities, or for the use or application of any moneys paid over by the Trustee in accordance with any provision of this Indenture
or established pursuant to Section 2.01, or for the use or application of any moneys received by any paying agent other than the Trustee.
Section
7.04 May Hold Securities.
The Trustee or any paying
agent or Security Registrar, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights
it would have if it were not Trustee, paying agent or Security Registrar.
Section
7.05 Moneys Held in Trust.
Subject to the provisions
of Section 11.05, all moneys received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes
for which they were received, but need not be segregated from other funds except to the extent required by law. The Trustee shall be
under no liability for interest on any moneys received by it hereunder except such as it may agree with the Company to pay thereon.
Section
7.06 Compensation and Reimbursement.
(a)
The Company shall pay to the Trustee for each of its capacities hereunder from time to time compensation for its services
as the Company and the Trustee shall from time to time agree upon in writing. The Trustee’s compensation shall not be limited by
any law on compensation of a trustee of an express trust. The Company shall reimburse the Trustee upon request for all reasonable out-of-pocket
expenses incurred by it. Such expenses shall include the reasonable compensation and expenses of the Trustee’s agents and counsel.
(b) The Company shall indemnify each of the Trustee in each of its capacities hereunder against any loss, liability or expense
(including the cost of defending itself and including the reasonable compensation and expenses of the Trustee’s agents and counsel)
incurred by it except as set forth in Section 7.06(c) in the exercise or performance of its powers, rights or duties under this Indenture
as Trustee or Agent. The Trustee shall notify the Company promptly of any claim for which it may seek indemnity. The Company shall defend
the claim and the Trustee shall cooperate in the defense. The Trustee may have one separate counsel and the Company shall pay the reasonable
fees and expenses of such counsel. The Company need not pay for any settlement made without its consent, which consent shall not be unreasonably
withheld. This indemnification shall apply to officers, directors, employees, shareholders and agents of the Trustee.
(c)
The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee or by any officer,
director, employee, shareholder or agent of the Trustee through negligence or bad faith.
(d) To ensure the Company’s payment obligations in this Section, the Trustee shall have a lien prior to the Securities on
all funds or property held or collected by the Trustee, except that held in trust to pay principal of or interest on particular Securities.
When the Trustee incurs expenses or renders services in connection with an Event of Default specified in Section 6.01(4) or (5), the
expenses (including the reasonable fees and expenses of its counsel) and the compensation for services in connection therewith are to
constitute expenses of administration under any insolvency law. The provisions of this Section 7.06 shall survive the termination of
this Indenture and the resignation or removal of the Trustee.
Section
7.07 Reliance on Officer’s Certificate.
Except as otherwise provided
in Section 7.01, whenever in the administration of the provisions of this Indenture the Trustee shall deem it reasonably necessary or
desirable that a matter be proved or established prior to taking or suffering or omitting to take any action hereunder, such matter (unless
other evidence in respect thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part of the
Trustee, be deemed to be conclusively proved and established by an Officer’s Certificate delivered to the Trustee and such certificate,
in the absence of negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered
or omitted to be taken by it under the provisions of this Indenture upon the faith thereof.
Section
7.08 Disqualification; Conflicting Interests.
If the Trustee has or shall
acquire any “conflicting interest” within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Company
shall in all respects comply with the provisions of Section 310(b) of the Trust Indenture Act.
Section
7.09 Corporate Trustee Required; Eligibility.
There shall at all times
be a Trustee with respect to the Securities issued hereunder which shall at all times be a corporation organized and doing business under
the laws of the United States of America or any state or territory thereof or of the District of Columbia, or a corporation or other
Person permitted to act as trustee by the Commission, authorized under such laws to exercise corporate trust powers, having a combined
capital and surplus of at least fifty million U.S. dollars ($50,000,000), and subject to supervision or examination by federal, state,
territorial, or District of Columbia authority.
If such corporation or other
Person publishes reports of condition at least annually, pursuant to law or to the requirements of the aforesaid supervising or examining
authority, then for the purposes of this Section, the combined capital and surplus of such corporation or other Person shall be deemed
to be its combined capital and surplus as set forth in its most recent report of condition so published. The Company may not, nor may
any Person directly or indirectly controlling, controlled by, or under common control with the Company, serve as Trustee. In case at
any time the Trustee shall cease to be eligible in accordance with the provisions of this Section, the Trustee shall resign immediately
in the manner and with the effect specified in Section 7.10.
Section
7.10 Resignation and Removal; Appointment of Successor.
(a)
The Trustee or any successor hereafter appointed may at any time resign with respect to the Securities of one or more series
by giving written notice thereof to the Company and the Securityholders of such series, as their names and addresses appear upon the
Security Register. Upon receiving such notice of resignation, the Company shall promptly appoint a successor trustee with respect to
Securities of such series by written instrument, in duplicate, executed by order of the Board of Directors, one copy of which instrument
shall be delivered to the resigning Trustee and one copy to the successor trustee. If no successor trustee shall have been so appointed
and have accepted appointment within 30 days after the sending of such notice of resignation, the resigning Trustee may petition any
court of competent jurisdiction for the appointment of a successor trustee with respect to Securities of such series, or any Securityholder
of that series who has been a bona fide holder of a Security or Securities for at least six months may on behalf of himself and all others
similarly situated, petition any such court for the appointment of a successor trustee. Such court may thereupon after such notice, if
any, as it may deem proper and prescribe, appoint a successor trustee.
(b) In case at any time any one of the following shall occur:
(i) the Trustee shall fail to comply with the provisions of Section 7.08 after written request therefor by the Company or by any
Securityholder who has been a bona fide holder of a Security or Securities for at least six months; or
(ii) the Trustee shall cease to be eligible in accordance with the provisions of Section 7.09 and shall fail to resign after written
request therefor by the Company or by any such Securityholder; or
(iii) the Trustee shall become incapable of acting, or shall be adjudged a bankrupt or insolvent, or commence a voluntary bankruptcy
proceeding, or a receiver of the Trustee or of its property shall be appointed or consented to, or any public officer shall take charge
or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation or liquidation;
then, in any such case, the
Company may remove the Trustee with respect to all Securities and appoint a successor trustee by written instrument, in duplicate, executed
by order of the Board of Directors, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor
trustee, or any Securityholder who has been a bona fide holder of a Security or Securities for at least six months may, on behalf of
that holder and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment
of a successor trustee. Such court may thereupon after such notice, if any, as it may deem proper and prescribe, remove the Trustee and
appoint a successor trustee.
(c)
The holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding may at any
time remove the Trustee with respect to such series by so notifying the Trustee and the Company and may appoint a successor Trustee for
such series with the consent of the Company.
(d) Any resignation or removal of the Trustee and appointment of a successor trustee with respect to the Securities of a series
pursuant to any of the provisions of this Section shall become effective upon acceptance of appointment by the successor trustee as provided
in Section 7.11.
(e)
Any successor trustee appointed pursuant to this Section may be appointed with respect to the Securities of one or more series
or all of such series, and at any time there shall be only one Trustee with respect to the Securities of any particular series.
Section
7.11 Acceptance of Appointment By Successor.
(a)
In case of the appointment hereunder of a successor trustee with respect to all Securities, every such successor trustee so
appointed shall execute, acknowledge and deliver to the Company and to the retiring Trustee an instrument accepting such appointment,
and thereupon the resignation or removal of the retiring Trustee shall become effective and such successor trustee, without any further
act, deed or conveyance, shall become vested with all the rights, powers, trusts and duties of the retiring Trustee; but, on the request
of the Company or the successor trustee, such retiring Trustee shall, upon payment of any amounts due to it pursuant to the provisions
of Section 7.06, execute and deliver an instrument transferring to such successor trustee all the rights, powers, and trusts of the retiring
Trustee and shall duly assign, transfer and deliver to such successor trustee all property and money held by such retiring Trustee hereunder.
(b)
In case of the appointment hereunder of a successor trustee with respect to the Securities of one or more (but not all) series,
the Company, the retiring Trustee and each successor trustee with respect to the Securities of one or more series shall execute and deliver
an indenture supplemental hereto wherein each successor trustee shall accept such appointment and which (i) shall contain such provisions
as shall be necessary or desirable to transfer and confirm to, and to vest in, each successor trustee all the rights, powers, trusts
and duties of the retiring Trustee with respect to the Securities of that or those series to which the appointment of such successor
trustee relates, (ii) shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers,
trusts and duties of the retiring Trustee with respect to the Securities of that or those series as to which the retiring Trustee is
not retiring shall continue to be vested in the retiring Trustee, and (iii) shall add to or change any of the provisions of this Indenture
as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one Trustee, it being understood
that nothing herein or in such supplemental indenture shall constitute such Trustees co-trustees of the same trust, that each such Trustee
shall be trustee of a trust or trusts hereunder separate and apart from any trust or trusts hereunder administered by any other such
Trustee and that no Trustee shall be responsible for any act or failure to act on the part of any other Trustee hereunder; and upon the
execution and delivery of such supplemental indenture the resignation or removal of the retiring Trustee shall become effective to the
extent provided therein, such retiring Trustee shall with respect to the Securities of that or those series to which the appointment
of such successor trustee relates have no further responsibility for the exercise of rights and powers or for the performance of the
duties and obligations vested in the Trustee under this Indenture, and each such successor trustee, without any further act, deed or
conveyance, shall become vested with all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities
of that or those series to which the appointment of such successor trustee relates; but, on request of the Company or any successor trustee,
such retiring Trustee shall duly assign, transfer and deliver to such successor trustee, to the extent contemplated by such supplemental
indenture, the property and money held by such retiring Trustee hereunder with respect to the Securities of that or those series to which
the appointment of such successor trustee relates.
(c)
Upon request of any such successor trustee, the Company shall execute any and all instruments for more fully and certainly
vesting in and confirming to such successor trustee all such rights, powers and trusts referred to in paragraph (a) or (b) of this Section,
as the case may be.
(d) No successor trustee shall accept its appointment unless at the time of such acceptance such successor trustee shall be qualified
and eligible under this Article.
(e)
Upon acceptance of appointment by a successor trustee as provided in this Section, the Company shall send notice of the succession
of such trustee hereunder to the Securityholders. If the Company fails to send such notice within ten days after acceptance of appointment
by the successor trustee, the successor trustee shall cause such notice to be sent at the expense of the Company.
Section
7.12 Merger, Conversion, Consolidation or Succession to Business.
Any corporation into which
the Trustee may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion
or consolidation to which the Trustee shall be a party, or any corporation succeeding to all or substantially all the corporate trust
business of the Trustee, including the administration of the trust created by this Indenture, shall be the successor of the Trustee hereunder,
provided that such corporation shall be qualified under the provisions of Section 7.08 and eligible under the provisions of Section 7.09,
without the execution or filing of any paper or any further act on the part of any of the parties hereto, anything herein to the contrary
notwithstanding. In case any Securities shall have been authenticated, but not delivered, by the Trustee then in office, any successor
by merger, conversion or consolidation to such authenticating Trustee may adopt such authentication and deliver the Securities so authenticated
with the same effect as if such successor Trustee had itself authenticated such Securities.
Section
7.13 Preferential Collection of Claims Against the Company.
The Trustee shall comply
with Section 311(a) of the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture
Act. A Trustee who has resigned or been removed shall be subject to Section 311(a) of the Trust Indenture Act to the extent included
therein.
Section
7.14 Notice of Default.
If any Event of Default occurs
and is continuing and if such Event of Default is known to a Responsible Officer of the Trustee, the Trustee shall send to each Securityholder
in the manner and to the extent provided in Section 313(c) of the Trust Indenture Act notice of the Event of Default within the earlier
of 90 days after it occurs and 30 days after it is known to a Responsible Officer of the Trustee or written notice of it is received
by the Trustee, unless such Event of Default has been cured; provided, however, that, except in the case of a default in the payment
of the principal of (or premium, if any) or interest on any Security, the Trustee shall be protected in withholding such notice if and
so long as the Responsible Officers of the Trustee in good faith determine that the withholding of such notice is in the interest of
the Securityholders.
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8
CONCERNING THE SECURITYHOLDERS
Section
8.01 Evidence of Action by Securityholders.
Whenever in this Indenture
it is provided that the holders of a majority or specified percentage in aggregate principal amount of the Securities of a particular
series may take any action (including the making of any demand or request, the giving of any notice, consent or waiver or the taking
of any other action), the fact that at the time of taking any such action the holders of such majority or specified percentage of that
series have joined therein may be evidenced by any instrument or any number of instruments of similar tenor executed by such holders
of Securities of that series in person or by agent or proxy appointed in writing.
If the Company shall solicit
from the Securityholders of any series any request, demand, authorization, direction, notice, consent, waiver or other action, the Company
may, at its option, as evidenced by an Officer’s Certificate, fix in advance a record date for such series for the determination
of Securityholders entitled to give such request, demand, authorization, direction, notice, consent, waiver or other action, but the
Company shall have no obligation to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent,
waiver or other action may be given before or after the record date, but only the Securityholders of record at the close of business
on the record date shall be deemed to be Securityholders for the purposes of determining whether Securityholders of the requisite proportion
of Outstanding Securities of that series have authorized or agreed or consented to such request, demand, authorization, direction, notice,
consent, waiver or other action, and for that purpose the Outstanding Securities of that series shall be computed as of the record date;
provided, however, that no such authorization, agreement or consent by such Securityholders on the record date shall be deemed effective
unless it shall become effective pursuant to the provisions of this Indenture not later than six months after the record date.
Section
8.02 Proof of Execution by Securityholders.
Subject to the provisions
of Section 7.01, proof of the execution of any instrument by a Securityholder (such proof will not require notarization) or his or her
agent or proxy and proof of the holding by any Person of any of the Securities shall be sufficient if made in the following manner:
(a)
The fact and date of the execution by any such Person of any instrument may be proved in any reasonable manner acceptable
to the Trustee.
(b) The ownership of Securities shall be proved by the Security Register of such Securities or by a certificate of the Security
Registrar thereof.
The Trustee may require such
additional proof of any matter referred to in this Section as it shall deem necessary.
Section
8.03 Who May be Deemed Owners.
Prior to the due presentment
for registration of transfer of any Security, the Company, the Trustee, any paying agent and any Security Registrar may deem and treat
the Person in whose name such Security shall be registered upon the books of the Security Registrar as the absolute owner of such Security
(whether or not such Security shall be overdue and notwithstanding any notice of ownership or writing thereon made by anyone other than
the Security Registrar) for the purpose of receiving payment of or on account of the principal of, premium, if any, and (subject to Section
2.03) interest on such Security and for all other purposes; and neither the Company nor the Trustee nor any paying agent nor any Security
Registrar shall be affected by any notice to the contrary.
Section
8.04 Certain Securities Owned by Company Disregarded.
In determining whether the
holders of the requisite aggregate principal amount of Securities of a particular series have concurred in any direction, consent or
waiver under this Indenture, the Securities of that series that are owned by the Company or any other obligor on the Securities of that
series or by any Person directly or indirectly controlling or controlled by or under common control with the Company or any other obligor
on the Securities of that series shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except
that for the purpose of determining whether the Trustee shall be protected in relying on any such direction, consent or waiver, only
Securities of such series that the Trustee actually knows are so owned shall be so disregarded. The Securities so owned that have been
pledged in good faith may be regarded as Outstanding for the purposes of this Section, if the pledgee shall establish to the satisfaction
of the Trustee the pledgee’s right so to act with respect to such Securities and that the pledgee is not a Person directly or indirectly
controlling or controlled by or under direct or indirect common control with the Company or any such other obligor. In case of a dispute
as to such right, any decision by the Trustee taken upon the advice of counsel shall be full protection to the Trustee.
Section
8.05 Actions Binding on Future Securityholders.
At any time prior to (but
not after) the evidencing to the Trustee, as provided in Section 8.01, of the taking of any action by the holders of the majority or
percentage in aggregate principal amount of the Securities of a particular series specified in this Indenture in connection with such
action, any holder of a Security of that series that is shown by the evidence to be included in the Securities the holders of which have
consented to such action may, by filing written notice with the Trustee, and upon proof of holding as provided in Section 8.02, revoke
such action so far as concerns such Security. Except as aforesaid any such action taken by the holder of any Security shall be conclusive
and binding upon such holder and upon all future holders and owners of such Security, and of any Security issued in exchange therefor,
on registration of transfer thereof or in place thereof, irrespective of whether or not any notation in regard thereto is made upon such
Security. Any action taken by the holders of the majority or percentage in aggregate principal amount of the Securities of a particular
series specified in this Indenture in connection with such action shall be conclusively binding upon the Company, the Trustee and the
holders of all the Securities of that series.
article
9
SUPPLEMENTAL INDENTURES
Section
9.01 Supplemental Indentures Without the Consent of Securityholders.
In addition to any supplemental
indenture otherwise authorized by this Indenture, the Company and the Trustee may from time to time and at any time enter into an indenture
or indentures supplemental hereto (which shall conform to the provisions of the Trust Indenture Act as then in effect), without the consent
of the Securityholders, for one or more of the following purposes:
(a)
to cure any ambiguity, defect, or inconsistency herein or in the Securities of any series;
(b) to comply with Article Ten;
(c)
to provide for uncertificated Securities in addition to or in place of certificated Securities;
(d) to add to the covenants, restrictions, conditions or provisions relating to the Company for the benefit of the holders of
all or any series of Securities (and if such covenants, restrictions, conditions or provisions are to be for the benefit of less than
all series of Securities, stating that such covenants, restrictions, conditions or provisions are expressly being included solely for
the benefit of such series), to make the occurrence, or the occurrence and the continuance, of a default in any such additional covenants,
restrictions, conditions or provisions an Event of Default, or to surrender any right or power herein conferred upon the Company;
(e)
to add to, delete from, or revise the conditions, limitations, and restrictions on the authorized amount, terms, or purposes
of issue, authentication, and delivery of Securities, as herein set forth;
(f) to
make any change that does not adversely affect the rights of any Securityholder in any material respect;
(g)
to provide for the issuance of and establish the form and terms and conditions of the Securities of any series as provided
in Section 2.01, to establish the form of any certifications required to be furnished pursuant to the terms of this Indenture or any
series of Securities, or to add to the rights of the holders of any series of Securities;
(h) to evidence and provide for the acceptance of appointment hereunder by a successor trustee; or
(i) to comply with any requirements of the Commission or any successor in connection with the qualification of this Indenture
under the Trust Indenture Act.
The Trustee is hereby authorized
to join with the Company in the execution of any such supplemental indenture, and to make any further appropriate agreements and stipulations
that may be therein contained, but the Trustee shall not be obligated to enter into any such supplemental indenture that affects the
Trustee’s own rights, duties or immunities under this Indenture or otherwise.
Any supplemental indenture
authorized by the provisions of this Section may be executed by the Company and the Trustee without the consent of the holders of any
of the Securities at the time Outstanding, notwithstanding any of the provisions of Section 9.02.
Section
9.02 Supplemental Indentures With Consent of Securityholders.
With the consent (evidenced
as provided in Section 8.01) of the holders of not less than a majority in aggregate principal amount of the Securities of each series
affected by such supplemental indenture or indentures at the time Outstanding, the Company, when authorized by a Board Resolution, and
the Trustee may from time to time and at any time enter into an indenture or indentures supplemental hereto (which shall conform to the
provisions of the Trust Indenture Act as then in effect) for the purpose of adding any provisions to or changing in any manner or eliminating
any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner not covered by Section 9.01 the
rights of the holders of the Securities of such series under this Indenture; provided, however, that no such supplemental indenture shall,
without the consent of the holders of each Security then Outstanding and affected thereby, (a) extend the fixed maturity of any Securities
of any series, or reduce the principal amount thereof, or reduce the rate or extend the time of payment of interest thereon, or reduce
any premium payable upon the redemption thereof or (b) reduce the aforesaid percentage of Securities, the holders of which are required
to consent to any such supplemental indenture.
It shall not be necessary
for the consent of the Securityholders of any series affected thereby under this Section to approve the particular form of any proposed
supplemental indenture, but it shall be sufficient if such consent shall approve the substance thereof.
Section
9.03 Effect of Supplemental Indentures.
Upon the execution of any
supplemental indenture pursuant to the provisions of this Article or of Section 10.01, this Indenture shall, with respect to such series,
be and be deemed to be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties
and immunities under this Indenture of the Trustee, the Company and the holders of Securities of the series affected thereby shall thereafter
be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and conditions
of any such supplemental indenture shall be and be deemed to be part of the terms and conditions of this Indenture for any and all purposes.
Section
9.04 Securities Affected by Supplemental Indentures.
Securities of any series
affected by a supplemental indenture, authenticated and delivered after the execution of such supplemental indenture pursuant to the
provisions of this Article or of Section 10.01, may bear a notation in form approved by the Company, provided such form meets the requirements
of any securities exchange upon which such series may be listed, as to any matter provided for in such supplemental indenture. If the
Company shall so determine, new Securities of that series so modified as to conform, in the opinion of the Board of Directors, to any
modification of this Indenture contained in any such supplemental indenture may be prepared by the Company, authenticated by the Trustee
and delivered in exchange for the Securities of that series then Outstanding.
Section
9.05 Execution of Supplemental Indentures.
Upon the request of the Company,
accompanied by its Board Resolutions authorizing the execution of any such supplemental indenture, and upon the filing with the Trustee
of evidence of the consent of Securityholders required to consent thereto as aforesaid, the Trustee shall join with the Company in the
execution of such supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities
under this Indenture or otherwise, in which case the Trustee may in its discretion but shall not be obligated to enter into such supplemental
indenture. The Trustee, subject to the provisions of Section 7.01, shall receive an Officer’s Certificate or an Opinion of Counsel
as conclusive evidence that any supplemental indenture executed pursuant to this Article is authorized or permitted by the terms of this
Article and that all conditions precedent to the execution of the supplemental indenture have been complied with; provided, however,
that such Officer’s Certificate or Opinion of Counsel need not be provided in connection with the execution of a supplemental indenture
that establishes the terms of a series of Securities pursuant to Section 2.01 hereof.
Promptly after the execution
by the Company and the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Company shall (or shall
direct the Trustee to) send a notice, setting forth in general terms the substance of such supplemental indenture, to the Securityholders
of all series affected thereby .as their names and addresses appear upon the Security Register. Any failure of the Company to send, or
cause the sending of, such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental
indenture.
article
10
SUCCESSOR ENTITY
Section
10.01 Company May Consolidate, Etc.
Nothing contained in this
Indenture shall prevent any consolidation or merger of the Company with or into any other Person (whether or not affiliated with the
Company) or successive consolidations or mergers in which the Company or its successor or successors shall be a party or parties, or
shall prevent any sale, conveyance, transfer or other disposition of the property of the Company or its successor or successors as an
entirety, or substantially as an entirety, to any other Person (whether or not affiliated with the Company or its successor or successors);
provided, however, the Company hereby covenants and agrees that, upon any such consolidation or merger (in each case, if the Company
is not the survivor of such transaction) or any such sale, conveyance, transfer or other disposition (other than a sale, conveyance,
transfer or other disposition to a Subsidiary of the Company), the due and punctual payment of the principal of (premium, if any) and
interest on all of the Securities of all series in accordance with the terms of each series, according to their tenor, and the due and
punctual performance and observance of all the covenants and conditions of this Indenture with respect to each series or established
with respect to such series pursuant to Section 2.01 to be kept or performed by the Company shall be expressly assumed, by supplemental
indenture (which shall conform to the provisions of the Trust Indenture Act, as then in effect) reasonably satisfactory in form to the
Trustee executed and delivered to the Trustee by the entity formed by such consolidation, or into which the Company shall have been merged,
or by the entity which shall have acquired such property.
Section
10.02 Successor Entity Substituted.
(a)
In case of any such consolidation, merger, sale, conveyance, transfer or other disposition and upon the assumption by the
successor entity by supplemental indenture, executed and delivered to the Trustee and satisfactory in form to the Trustee, of the obligations
set forth under Section 10.01 on all of the Securities of all series Outstanding, such successor entity shall succeed to and be substituted
for the Company with the same effect as if it had been named as the Company herein, and thereupon the predecessor corporation shall be
relieved of all obligations and covenants under this Indenture and the Securities.
(b) In case of any such consolidation, merger, sale, conveyance, transfer or other disposition, such changes in phraseology and
form (but not in substance) may be made in the Securities thereafter to be issued as may be appropriate.
(c)
Nothing contained in this Article shall require any action by the Company in the case of a consolidation or merger of any
Person into the Company where the Company is the survivor of such transaction, or the acquisition by the Company, by purchase or otherwise,
of all or any part of the property of any other Person (whether or not affiliated with the Company).
article
11
SATISFACTION AND DISCHARGE
Section
11.01 Satisfaction and Discharge of Indenture.
If at any time: (a) the Company
shall have delivered to the Trustee for cancellation all Securities of a series theretofore authenticated and not delivered to the Trustee
for cancellation (other than any Securities that shall have been destroyed, lost or stolen and that shall have been replaced or paid
as provided in Section 2.07 and Securities for whose payment money or Governmental Obligations have theretofore been deposited in trust
or segregated and held in trust by the Company and thereupon repaid to the Company or discharged from such trust, as provided in Section
11.05); or (b) all such Securities of a particular series not theretofore delivered to the Trustee for cancellation shall have become
due and payable, or are by their terms to become due and payable within one year or are to be called for redemption within one year under
arrangements satisfactory to the Trustee for the giving of notice of redemption, and the Company shall deposit or cause to be deposited
with the Trustee as trust funds the entire amount in moneys or Governmental Obligations or a combination thereof, sufficient in the opinion
of a nationally recognized firm of independent public accountants expressed in a written certification thereof delivered to the Trustee,
to pay at maturity or upon redemption all Securities of that series not theretofore delivered to the Trustee for cancellation, including
principal (and premium, if any) and interest due or to become due to such date of maturity or date fixed for redemption, as the case
may be, and if the Company shall also pay or cause to be paid all other sums payable hereunder with respect to such series by the Company
then this Indenture shall thereupon cease to be of further effect with respect to such series except for the provisions of Sections 2.03,
2.05, 2.07, 4.01, 4.02, 4.03, 7.10, 11.05 and 13.04, that shall survive until the date of maturity or redemption date, as the case may
be, and Sections 7.06 and 11.05, that shall survive to such date and thereafter, and the Trustee, on demand of the Company and at the
cost and expense of the Company shall execute proper instruments acknowledging satisfaction of and discharging this Indenture with respect
to such series.
Section
11.02 Discharge of Obligations.
If at any time all such Securities
of a particular series not heretofore delivered to the Trustee for cancellation or that have not become due and payable as described
in Section 11.01 shall have been paid by the Company by depositing irrevocably with the Trustee as trust funds moneys or an amount of
Governmental Obligations sufficient to pay at maturity or upon redemption all such Securities of that series not theretofore delivered
to the Trustee for cancellation, including principal (and premium, if any) and interest due or to become due to such date of maturity
or date fixed for redemption, as the case may be, and if the Company shall also pay or cause to be paid all other sums payable hereunder
by the Company with respect to such series, then after the date such moneys or Governmental Obligations, as the case may be, are deposited
with the Trustee the obligations of the Company under this Indenture with respect to such series shall cease to be of further effect
except for the provisions of Sections 2.03, 2.05, 2.07, 4,01, 4.02, 4,03, 7.06, 7.10, 11.05 and 13.04 hereof that shall survive until
such Securities shall mature and be paid.
Thereafter, Sections 7.06
and 11.05 shall survive.
Section
11.03 Deposited Moneys to be Held in Trust.
All moneys or Governmental
Obligations deposited with the Trustee pursuant to Sections 11.01 or 11.02 shall be held in trust and shall be available for payment
as due, either directly or through any paying agent (including the Company acting as its own paying agent), to the holders of the particular
series of Securities for the payment or redemption of which such moneys or Governmental Obligations have been deposited with the Trustee.
Section
11.04 Payment of Moneys Held by Paying Agents.
In connection with the satisfaction
and discharge of this Indenture all moneys or Governmental Obligations then held by any paying agent under the provisions of this Indenture
shall, upon demand of the Company, be paid to the Trustee and thereupon such paying agent shall be released from all further liability
with respect to such moneys or Governmental Obligations.
Section
11.05 Repayment to Company.
Any moneys or Governmental
Obligations deposited with any paying agent or the Trustee, or then held by the Company, in trust for payment of principal of or premium,
if any, or interest on the Securities of a particular series that are not applied but remain unclaimed by the holders of such Securities
for at least two years after the date upon which the principal of (and premium, if any) or interest on such Securities shall have respectively
become due and payable, or such other shorter period set forth in applicable escheat or abandoned or unclaimed property law, shall be
repaid to the Company on May 31 of each year or upon the Company’s request or (if then held by the Company) shall be discharged
from such trust; and thereupon the paying agent and the Trustee shall be released from all further liability with respect to such moneys
or Governmental Obligations, and the holder of any of the Securities entitled to receive such payment shall thereafter, as a general
creditor, look only to the Company for the payment thereof.
article
12
IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND DIRECTORS
Section
12.01 No Recourse.
No recourse under or upon
any obligation, covenant or agreement of this Indenture, or of any Security, or for any claim based thereon or otherwise in respect thereof,
shall be had against any incorporator, stockholder, officer or director, past, present or future as such, of the Company or of any predecessor
or successor corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue
of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood
that this Indenture and the obligations issued hereunder are solely corporate obligations, and that no such personal liability whatever
shall attach to, or is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of
any predecessor or successor corporation, or any of them, because of the creation of the indebtedness hereby authorized, or under or
by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom; and
that any and all such personal liability of every name and nature, either at common law or in equity or by constitution or statute, of,
and any and all such rights and claims against, every such incorporator, stockholder, officer or director as such, because of the creation
of the indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture
or in any of the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration
for, the execution of this Indenture and the issuance of such Securities.
article
13
MISCELLANEOUS PROVISIONS
Section
13.01 Effect on Successors and Assigns.
All the covenants, stipulations,
promises and agreements in this Indenture made by or on behalf of the Company shall bind its successors and assigns, whether so expressed
or not.
Section
13.02 Actions by Successor.
Any act or proceeding by
any provision of this Indenture authorized or required to be done or performed by any board, committee or officer of the Company shall
and may be done and performed with like force and effect by the corresponding board, committee or officer of any corporation that shall
at the time be the lawful successor of the Company.
Section
13.03 Surrender of Company Powers.
The Company by instrument
in writing executed by authority of its Board of Directors and delivered to the Trustee may surrender any of the powers reserved to the
Company, and thereupon such power so surrendered shall terminate both as to the Company and as to any successor corporation.
Section
13.04 Notices.
Except as otherwise expressly
provided herein, any notice, request or demand that by any provision of this Indenture is required or permitted to be given, made or
served by the Trustee, the Security Registrar, any paying or other agent under this Indenture or by the holders of Securities or by any
other Person pursuant to this Indenture to or on the Company may be given or served by being deposited in first class mail, postage prepaid,
addressed (until another address is filed in writing by the Company with the Trustee), as follows: .
Any notice, election, request or demand by the Company or any Securityholder or by any other Person pursuant to this Indenture to or
upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if given or made in writing at the Corporate
Trust Office of the Trustee.
Section
13.05 Governing Law; Jury Trial Waiver.
This Indenture and each Security
shall be governed by, and construed in accordance with, the internal laws of the State of New York, except to the extent that the Trust
Indenture Act is applicable.
EACH PARTY HERETO, AND EACH
HOLDER OF A SECURITY BY ACCEPTANCE THEREOF, HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO
A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS INDENTURE.
Section
13.06 Treatment of Securities as Debt.
It is intended that the Securities
will be treated as indebtedness and not as equity for federal income tax purposes. The provisions of this Indenture shall be interpreted
to further this intention.
Section
13.07 Certificates and Opinions as to Conditions Precedent.
(a)
Upon any application or demand by the Company to the Trustee to take any action under any of the provisions of this Indenture,
the Company shall furnish to the Trustee an Officer’s Certificate stating that all conditions precedent provided for in this Indenture
(other than the certificate to be delivered pursuant to Section 13.12) relating to the proposed action have been complied with and, if
requested, an Opinion of Counsel stating that in the opinion of such counsel all such conditions precedent have been complied with, except
that in the case of any such application or demand as to which the furnishing of such documents is specifically required by any provision
of this Indenture relating to such particular application or demand, no additional certificate or opinion need be furnished.
(b)
Each certificate or opinion provided for in this Indenture and delivered to the Trustee with respect to compliance with a
condition or covenant in this Indenture (other than the certificate to be delivered pursuant to Section 13.12 of this Indenture or Section
314(a)(1) of the Trust Indenture Act) shall include (i) a statement that the Person making such certificate or opinion has read such
covenant or condition; (ii) a brief statement as to the nature and scope of the examination or investigation upon which the statements
or opinions contained in such certificate or opinion are based; (iii) a statement that, in the opinion of such Person, he has made such
examination or investigation as is reasonably necessary to enable him to express an informed opinion as to whether or not such covenant
or condition has been complied with; and (iv) a statement as to whether or not, in the opinion of such Person, such condition or covenant
has been complied with.
Section
13.08 Payments on Business Days.
Except as provided pursuant
to Section 2.01 pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures
supplemental to this Indenture, in any case where the date of maturity of interest or principal of any Security or the date of redemption
of any Security shall not be a Business Day, then payment of interest or principal (and premium, if any) may be made on the next succeeding
Business Day with the same force and effect as if made on the nominal date of maturity or redemption, and no interest shall accrue for
the period after such nominal date.
Section
13.09 Conflict with Trust Indenture Act.
If and to the extent that
any provision of this Indenture limits, qualifies or conflicts with the duties imposed by Section 318(c) of the Trust Indenture Act,
such imposed duties shall control.
Section
13.10 Counterparts.
This Indenture may be executed
in any number of counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same
instrument. The exchange of copies of this Indenture and of signature pages by facsimile or PDF transmission shall constitute effective
execution and delivery of this Indenture as to the parties hereto and may be used in lieu of the original Indenture for all purposes.
Signatures of the parties hereto transmitted by facsimile or PDF shall be deemed to be their original signatures for all purposes.
Section
13.11 Separability.
In case any one or more of
the provisions contained in this Indenture or in the Securities of any series shall for any reason be held to be invalid, illegal or
unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Indenture
or of such Securities, but this Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable provision
had never been contained herein or therein.
Section
13.12 Compliance Certificates.
The Company shall deliver
to the Trustee, within 120 days after the end of each fiscal year during which any Securities of any series were outstanding, an officer’s
certificate stating whether or not the signers know of any Event of Default that occurred during such fiscal year. Such certificate shall
contain a certification from the principal executive officer, principal financial officer or principal accounting officer of the Company
that a review has been conducted of the activities of the Company and the Company’s performance under this Indenture and that the
Company has complied with all conditions and covenants under this Indenture. For purposes of this Section 13.12, such compliance shall
be determined without regard to any period of grace or requirement of notice provided under this Indenture. If the officer of the Company
signing such certificate has knowledge of such an Event of Default, the certificate shall describe any such Event of Default and its
status.
Section
13.13 U.S.A Patriot Act.
The parties hereto acknowledge
that in accordance with Section 326 of the U.S.A. Patriot Act, the Trustee, like all financial institutions and in order to help fight
the funding of terrorism and money laundering, is required to obtain, verify, and record information that identifies each person or legal
entity that establishes a relationship or opens an account with the Trustee. The parties to this Indenture agree that they will provide
the Trustee with such information as it may request in order for the Trustee to satisfy the requirements of the U.S.A. Patriot Act.
Section
13.14 Force Majeure.
In no event shall the Trustee,
the Security Registrar, any paying agent or any other agent under this Indenture be responsible or liable for any failure or delay in
the performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including
without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
catastrophes or acts of God, and interruptions, loss or malfunctions or utilities, communications or computer (software and hardware)
services; it being understood that the Trustee, the Security Registrar, any paying agent or any other agent under this Indenture shall
use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable
under the circumstances.
Section
13.15 Table of Contents; Headings.
The table of contents and
headings of the articles and sections of this Indenture have been inserted for convenience of reference only, are not intended to be
considered a part hereof, and will not modify or restrict any of the terms or provisions hereof.
In
Witness Whereof, the parties hereto have caused this Indenture to be duly executed all as of the day and year first above
written.
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Title: |
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CROSS-REFERENCE TABLE (1)
Section
of Trust Indenture Act of 1939, as Amended |
|
Section
of Indenture |
310(a) |
|
7.09 |
310(b) |
|
7.08 |
|
|
7.10 |
310(c) |
|
Inapplicable |
311(a) |
|
7.13 |
311(b) |
|
7.13 |
311(c) |
|
Inapplicable |
312(a) |
|
5.01 |
|
|
5.02(a) |
312(b) |
|
5.02(c) |
312(c) |
|
5.02(c) |
313(a) |
|
5.04(a) |
313(b) |
|
5.04(b) |
313(c) |
|
5.04(a) |
|
|
5.04(b) |
313(d) |
|
5.04(c) |
314(a) |
|
5.03 |
|
|
13.12 |
314(b) |
|
Inapplicable |
314(c) |
|
13.07(a) |
314(d) |
|
Inapplicable |
314(e) |
|
13.07(b) |
314(f) |
|
Inapplicable |
315(a) |
|
7.01(a) |
|
|
7.01(b) |
315(b) |
|
7.14 |
315(c) |
|
7.01 |
315(d) |
|
7.01(b) |
315(e) |
|
6.07 |
316(a) |
|
6.06 |
|
|
8.04 |
316(b) |
|
6.04 |
316(c) |
|
8.01 |
317(a) |
|
6.02 |
317(b) |
|
4.03 |
318(a) |
|
13.09 |
| (1) | This Cross-Reference Table does not constitute
part of the Indenture and shall not have any bearing on the interpretation of any of its
terms or provisions. |
Exhibit 5.1
Zura Bio Limited
c/o Maples Corporate Services Limited,
PO Box 309, Ugland House,
Grand Cayman, KY1-1104
Cayman Islands |
|
D +1 345 949 9876 |
|
E bradley.kruger@ogier.com |
|
|
|
Reference: 502885.00001 |
|
|
|
|
|
|
|
3 September 2024 |
Zura Bio Limited (the Company)
We have acted as Cayman Islands legal advisers
to the Company in connection with the Company’s registration statement on Form S-3, including all amendments or preliminary
or final supplements thereto, filed with the United States Securities and Exchange Commission (the Commission) under the United
States Securities Act of 1933 (the Act), as amended, (including its exhibits, the Registration Statement) related to the
offering and sale of up to US$300,000,000 in the aggregate of our Class A ordinary shares, par value $0.0001 per share (the Class A
Ordinary Shares), preferred shares, debt securities, warrants and/or units (the Securities), including up to US$125,000,000
in the aggregate of our Class A Ordinary Shares, that may be issued and sold under the Sales Agreement (as defined below).
We have been advised that the Securities may be
issued and sold or delivered from time to time as set forth in the Registration Statement and any amendment thereto under Rules 462(b) of
the Act and that this opinion is required to be furnished in accordance with Registration Statement. No opinion is expressed herein as
to any matter pertaining to the contents of the Registration Statement other than as expressly stated herein with respect to the issue
of the Class A Ordinary Shares.
We have reviewed (i) the prospectus dated 3 September 2024
included in the Registration Statement (the Prospectus); and (ii) the sales agreement dated 3 September 2024 related to the
issue and sale of up to US$125,000,000 in the aggregate of our Class A Ordinary Shares through Leerink Partners LLC (the Agent)
by and between the Company and the Agent (the Sales Agreement) pursuant to which Ordinary Shares may be issued.
Ogier (Cayman) LLP
89 Nexus Way
Camana Bay
Grand Cayman, KY1-9009
Cayman Islands
T +1 345 949 9876
F +1 345 949 9877
ogier.com |
A
list of Partners may be inspected on our website |
Zura Bio Limited
3 September 2024
This opinion is given in accordance with the terms
of the Legal Matters section of the Registration Statement.
A reference to a Schedule is a reference to a
schedule to this opinion and the headings herein are for convenience only and do not affect the construction of this opinion.
For the purposes of giving this opinion,
we have examined a copy of the Registration Statement, the Prospectus and the Sales Agreement. In addition, we have examined the corporate
and other documents listed in Schedule 1. We have not made any searches or enquiries concerning, and have not examined any documents entered
into by or affecting the Company or any other person, save for the searches, enquiries and examinations expressly referred to in Schedule
1.
In giving this opinion we have relied
upon the assumptions set forth in Schedule 2 without having carried out any independent investigation or verification in respect of those
assumptions.
On the basis of the examinations and
assumptions referred to above and subject to the qualifications set forth in Schedule 3 and the limitations set forth below, we are of
the opinion that:
Corporate status
| (a) | The Company has been duly incorporated as an exempted company with limited liability and is validly existing
and in good standing with the Registrar of Companies of the Cayman Islands (the Registrar). |
Corporate power
| (b) | The Company has all requisite power under its M&A (as defined in Schedule 1) to issue the Class A
Ordinary Shares, to execute and deliver the Sales Agreement and to perform its obligations, and exercise its rights, under the Sales Agreement. |
Corporate authorisation
| (c) | The Company has taken all requisite corporate action to authorise: |
| (i) | the issuance of the Class A Ordinary Shares; and |
| (ii) | the execution and delivery of the Sales Agreement and the performance of its obligations, and the exercise
of its rights, under such documents. |
Zura Bio Limited
3 September 2024
Shares
| (d) | The Class A Ordinary Shares to be offered and issued by the Company as contemplated by the Registration
Statement, when issued by the Company upon: |
| (i) | payment in full of the consideration as set out in the Registration Statement and in accordance with the
terms set out in the Registration Statement and in accordance with the M&A; and |
| (ii) | the entry of those Class A Ordinary Shares as fully paid on the register of members of the Company, |
shall be validly issued, fully paid and
non-assessable. As a matter of Cayman Islands law, the Class A Ordinary Shares are only issued when they have been entered into the
register of members of the Company.
We offer no opinion:
| (a) | as to any laws other than the laws of the Cayman Islands, and we have not, for the purposes of this opinion,
made any investigation of the laws of any other jurisdiction, and we express no opinion as to the meaning, validity, or effect of references
in the documents to statutes, rules, regulations, codes or judicial authority of any jurisdiction other than the Cayman Islands; |
| (b) | except to the extent that this opinion expressly provides otherwise, as to the commercial terms of, or
the validity, enforceability or effect of the documents reviewed (or as to how the commercial terms of such documents reflect the intentions
of the parties), the accuracy of representations, the fulfilment of warranties or conditions, the occurrence of events of default or terminating
events or the existence of any conflicts or inconsistencies among the documents and any other agreements into which the Company may have
entered or any other documents; or |
| (c) | as to whether the acceptance, execution or performance of the Company’s obligations under the documents
reviewed by us will result in the breach of or infringe any other agreement, deed or document (other than the M&A) entered into by
or binding on the Company. |
Zura Bio Limited
3 September 2024
5 | Governing law of this opinion |
| (a) | governed by, and shall be construed in accordance with, the laws of the Cayman Islands; |
| (b) | limited to the matters expressly stated in it; and |
| (c) | confined to, and given on the basis of, the laws and practice in the Cayman Islands at the date of this
opinion. |
| 5.2 | Unless otherwise indicated, a reference to any specific Cayman Islands legislation is a reference to that
legislation as amended to, and as in force at, the date of this opinion. |
We hereby consent to the filing of this
opinion as an exhibit to the Registration Statement and also consent to the reference to this firm in the Registration Statement under
the heading “Legal Matters”. In the giving of our consent, we do not thereby admit that we are in the category of persons
whose consent is required under Section 7 of the Act or the Rules and Regulations of the Commission thereunder.
This opinion may be used only in connection
with the offer and sale of the Class A Ordinary Shares while the Registration Statement is effective.
Yours faithfully
/s/ Ogier
Ogier (Cayman) LLP
Zura Bio Limited
3 September 2024
Schedule
1
Documents examined
Corporate and other documents
1 | The Certificate of Incorporation of the Company dated 10 March 2021 and the Certificate of Incorporation
on Change of Name of the Company dated 21 March 2023, each issued by the Registrar (together, the Certificate of Incorporation). |
2 | The amended and restated memorandum of association (the Memorandum) and amended and restated articles
of association of the Company, as adopted by special resolution passed on 16 March 2023 and effective on 20 March 2023 (together
with the Memorandum, the M&A). |
3 | A Certificate of Good Standing dated 30 August 2024 (the Good Standing Certificate) issued by
the Registrar in respect of the Company. |
4 | A certificate dated on the date hereof as to certain matters of fact signed by a director of the Company
in the form annexed hereto (the Director’s Certificate), having attached to it a copy of the written resolutions of the directors
of the Company passed on 31 August 2024 (the Resolutions). |
5 | The Register of Writs and Other Originating Process maintained by the office of the Clerk of Courts in
the Cayman Islands as inspected by us on 3 September 2024 (the Register of Writs). |
| 6 | A draft specimen certificate for Class A Ordinary Shares (the Share Certificates). |
Zura Bio Limited
3 September 2024
Schedule
2
Assumptions
Assumptions
of general application
| 1 | All original documents examined by us are authentic and complete. |
| 2 | All copy documents examined by us (whether in facsimile, electronic or other form) conform to the originals
and those originals are authentic and complete. |
| 3 | All signatures, seals, dates, stamps and markings (whether on original or copy documents) are genuine. |
| 4 | Each of the Certificate of Incorporation and the M&A is in full force and effect and is accurate and
complete as at the date of this opinion. |
| 5 | The M&A have not been amended, varied, supplemented or revoked in any respect. |
| 6 | The powers and authority of the directors set out in the M&A have not been varied or restricted in
any way by resolution or direction of the shareholders of the Company. |
| 7 | Each of the Good Standing Certificate and the Director’s Certificate is accurate and complete as
at the date of this opinion. |
| 8 | Where any document has been provided to us in draft or undated form, that document has been executed by
all parties in materially the form provided to us and, where we have been provided with successive drafts of a document marked to show
changes from a previous draft, all such changes have been accurately marked. |
| 9 | There will be no intervening circumstance relevant to this opinion between the date hereof and the date
upon which the Class A Ordinary Shares are issued. |
| 10 | There is nothing under any law (other than the laws of the Cayman Islands) that would or might affect
the opinions herein. |
Status, authorisation and execution
| 11 | Each of the parties to the documents other than the Company is duly incorporated, formed or organised
(as applicable), validly existing and in good standing under all relevant laws. |
| 12 | Any individuals who are parties to the documents or who sign or have signed documents or who give or have
given information on which we rely, have the legal capacity under all relevant laws (including the laws of the Cayman Islands) to enter
into and perform their obligations under such documents, sign such documents and give such information. |
Zura Bio Limited
3 September 2024
| 13 | Each document has been duly authorised, executed and unconditionally delivered by or on behalf of all
parties to it in accordance with all applicable laws (other than, in the case of the Company, the laws of the Cayman Islands). |
| 14 | In authorising the execution and delivery of the documents by the Company, the filing of the Registration
Statement and Prospectus, the exercise of its rights and performance of its obligations under the documents and the issue and allotment
of the Class A Ordinary Shares, each of the directors of the Company has acted in good faith with a view to the best interests of
the Company and has exercised the standard of care, diligence and skill that is required of him or her. |
| 15 | Each document has been duly executed and unconditionally delivered by the Company in the manner authorised
in the Resolutions. |
| 16 | The person named in the Resolutions as authorised to execute the documents on behalf of the Company in
fact executed such documents with the intention to bind the Company. |
| 17 | The Resolutions remain in full force and effect and each of the directors of the Company has acted in
good faith with a view to the best interests of the Company and has exercised the standard of care, diligence and skill that is required
of him or her in approving the documents and no director has a financial interest in or other relationship to a party of the transactions
contemplated by the documents which has not been properly disclosed in the Resolutions; |
| 18 | Each of the parties to the documents other than the Company is duly incorporated, formed or organized
(as applicable), validly existing and in good standing under all relevant laws. Any individuals who are parties to the documents, or who
sign or have signed, or who give or have given information on which we rely, have the legal capacity under all relevant laws (including
the laws of the Cayman Islands) to enter into and perform their obligations under such documents, sign such documents and give such information. |
Enforceability
| 19 | Each of the Documents is legal, valid, binding and enforceable against all relevant parties in accordance
with its terms under its governing law and all other relevant laws (other than, in the case of the Company, the laws of the Cayman Islands). |
| 20 | If an obligation is to be performed in a jurisdiction outside the Cayman Islands, its performance will
not be contrary to an official directive, impossible or illegal under the laws of that jurisdiction. |
| 21 | None of the opinions expressed herein will be adversely affected by the laws or public policies of any
jurisdiction other than the Cayman Islands. In particular, but without limitation to the previous sentence: |
| (a) | the laws or public policies of any jurisdiction other than the Cayman Islands will not adversely affect
the capacity or authority of the Company; and |
Zura Bio Limited
3 September 2024
| (b) | neither the execution or delivery of the documents nor the exercise by any party to the documents of its
rights or the performance of its obligations under them contravene those laws or public policies. |
| 22 | There are no agreements, documents or arrangements (other than the documents expressly referred to in
this opinion as having been examined by us) that materially affect or modify the documents or the transactions contemplated by them or
restrict the powers and authority of the Company in any way. |
| 23 | No moneys paid to or for the account of any party under a Document represent, or will represent, criminal
property or terrorist property (as defined in the Proceeds of Crime Act (Revised) of the Cayman Islands and the Terrorism Act (Revised)
of the Cayman Islands respectively). None of the parties to the Documents is acting or will act in relation to the transactions contemplated
by the Documents, in a manner inconsistent with sanctions imposed by Cayman Islands authorities, the European Union, the United Nations
or United Kingdom sanctions or measures extended by statutory instrument to the Cayman Islands by order of His Majesty in Council. |
| 24 | None of the transactions contemplated by the documents relate to any shares, voting rights or other rights
that are subject to a restrictions notice issued pursuant to the Companies Act (Revised) (the Companies Act) of the Cayman Islands
(a Restrictions Notice). |
Approvals, consents and filings
| 25 | The Company has obtained all consents, licences, approvals and authorisations of any governmental or regulatory
authority or agency or of any other person that it is required to obtain pursuant to the laws of all relevant jurisdictions (other than
those of the Cayman Islands) to ensure the legality, validity, enforceability, proper performance and admissibility in evidence of the
Documents. Any conditions to which such consents, licences, approvals and authorisations are subject have been, and will continue to be,
satisfied or waived by the parties entitled to the benefit of them. |
| 26 | All of the following that are necessary to ensure the validity, legality, enforceability or admissibility
in evidence of the Documents have been made or paid: |
| (a) | all notarisations, apostillings and consularisations required pursuant to the laws of all relevant jurisdictions
(other than those of the Cayman Islands); and |
| (b) | all filings, recordings, registrations and enrolments of the Documents with any court, public office or
elsewhere in any jurisdiction outside the Cayman Islands; and |
| (c) | all payments outside the Cayman Islands of stamp duty, registration or other tax on or in relation to
the Documents. |
| 26.2 | No Class A Ordinary Shares will be issued unless and until all required Nasdaq approvals and shareholder
approvals required by the rules and regulations of Nasdaq (if any) have been obtained. Any conditions to which such approvals are
subject have been, and will continue to be, satisfied or waived by the parties entitled to the benefit of them. |
Zura Bio Limited
3 September 2024
Share Issuance
| 27 | The Class A Ordinary Shares shall be issued at an issue price in excess of the par value thereof
and shall be entered on the register of members of the Company as fully paid. |
| 28 | The maximum number of the Class A Shares to be issued by the Company would not exceed the Company's
authorised share capital. |
| 29 | There are no circumstances or matters of fact existing which may properly form the basis for an application
for an order for rectification of the register of members of the Company. |
| 30 | No invitation has been or will be made by or on behalf of the Company to the public in the Cayman Islands
to subscribe for any of the Class A Shares; |
| 31 | All necessary corporate action will be taken to authorise and approve any issuance of Class A Ordinary
Shares, the terms of the offering of such Class A Ordinary Shares and other related matters and the applicable definitive purchase,
underwriting or similar agreement will be duly approved, executed and delivered by or on behalf of the Company and all other parties thereto. |
| 32 | Neither the directors nor the shareholders of the Company have taken any steps to appoint a liquidator
of the Company and no receiver or restructuring officer has been appointed over any of the Company’s property or assets. |
Sovereign immunity
| 33 | The Company is not a sovereign entity of any state and does not have sovereign immunity for the purposes
of the UK State Immunity Act 1978 (which has been extended by statutory instrument to the Cayman Islands). |
Zura Bio Limited
3 September 2024
Schedule
3
Qualifications
Good Standing
| 1 | Under the Companies Act annual returns in respect of the Company must be filed with the Registrar, together
with payment of annual filing fees. A failure to file annual returns and pay annual filing fees may result in the Company being struck
off the Register of Companies, following which its assets will vest in the Financial Secretary of the Cayman Islands and will be subject
to disposition or retention for the benefit of the public of the Cayman Islands. |
| 2 | In good standing means only that as of the date of the Good Standing Certificate the Company is
up-to-date with the filing of its annual returns and payment of annual fees with the Registrar. We have made no enquiries into the Company's
good standing with respect to any filings or payment of fees, or both, that it may be required to make under the laws of the Cayman Islands
other than the Companies Act. |
Limited liability
| 3 | We are not aware of any Cayman Islands authority as to when the courts would set aside the limited liability
of a shareholder in a Cayman Islands company. Our opinion on the subject is based on the Companies Act and English common law authorities,
the latter of which are persuasive but not binding in the courts of the Cayman Islands. Under English authorities, circumstances in which
a court would attribute personal liability to a shareholder are very limited, and include: (a) such shareholder expressly assuming
direct liability (such as a guarantee); (b) the company acting as the agent of such shareholder; (c) the company being incorporated
by or at the behest of such shareholder for the purpose of committing or furthering such shareholder’s fraud, or for a sham transaction
otherwise carried out by such shareholder. In the absence of these circumstances, we are of the opinion that a Cayman Islands’ court
would have no grounds to set aside the limited liability of a shareholder. |
Non-Assessable
| 4 | In this opinion, the phrase “non-assessable” means, with respect to the Class A Ordinary
Shares in the Company, that a shareholder shall not, solely by virtue of its status as a shareholder, be liable for additional assessments
or calls on the Class A Ordinary Shares by the Company or its creditors (except in exceptional circumstances, such as involving fraud,
the establishment of an agency relationship or an illegal or improper purpose or other circumstance in which a court may be prepared to
pierce or lift the corporate veil). |
Register of Writs
| 5 | Our examination of the Register of Writs cannot conclusively reveal whether or not there is: |
| (a) | any current or pending litigation in the Cayman Islands against the Company; or |
Zura Bio Limited
3 September 2024
| (b) | any application for the winding up or dissolution of the Company or the appointment of any liquidator,
trustee in bankruptcy or restructuring officer in respect of the Company or any of its assets, |
as notice of these matters might not
be entered on the Register of Writs immediately or updated expeditiously or the court file associated with the matter or the matter itself
may not be publicly available (for example, due to sealing orders having been made). Furthermore, we have not conducted a search of the
summary court. Claims in the summary court are limited to a maximum of CI $20,000.
Enforceability
| 6 | In this opinion, the term “enforceable” means that the relevant obligations are of a type
that the courts of the Cayman Islands will ordinarily enforce, but it does not mean that those obligations will necessarily be enforced
in all circumstances in accordance with their terms. In particular, but without limitation: |
| (a) | enforcement may be limited by insolvency or similar laws affecting the rights of creditors; |
| (b) | enforcement may be limited by general principles of equity. In particular, equitable remedies, such as
specific performance and injunction, will only be granted by a court in its discretion and may not be available where the court considers
damages to be an adequate remedy; |
| (c) | a claim may be barred by statutes of limitation, or it may be or become subject to defences of set-off,
abatement, laches or counterclaim and the doctrines of estoppel, waiver, election, forbearance or abandonment; |
| (d) | a court may refuse to allow unjust enrichment; |
| (e) | enforcement of an obligation of a party under a Document may be invalidated or vitiated by reason of fraud,
duress, misrepresentation or undue influence or it may be limited by Cayman Islands law dealing with frustration of contracts; |
| (f) | a provision of a Document that fetters any statutory power of a Cayman Islands’ company, such as
a provision restricting the company’s power to commence its winding up, to alter its memorandum and articles of association or to
increase its share capital, may not be enforceable; |
| (g) | the effectiveness of a provision in a Document releasing a party from a liability or duty otherwise owed
may be limited by law; |
| (h) | a court will not enforce a provision of a Document to the extent that it may be illegal or contrary to
public policy in the Cayman Islands or purports to bar a party unconditionally from, seeking any relief from the courts of the Cayman
Islands or any other court or tribunal chosen by the parties; |
Zura Bio Limited
3 September 2024
| (i) | a provision of a Document is construed as being penal in nature, in that it provides that a breach of
a primary obligation results in a secondary obligation that imposes a detriment on the contract-breaker out of all proportion to any legitimate
interest of the innocent party in the enforcement of the primary obligation, will not be enforceable (and we express no opinion as to
whether such a provision is proportionate); |
| (j) | a court may refuse to give effect to a provision in a Document (including a provision that relates to
contractual interest on a judgment debt) that it considers usurious; |
| (k) | a court may not enforce a provision of a Document to the extent that the transactions contemplated by
it contravene economic or other sanctions imposed in respect of certain states or jurisdictions by a treaty, law, order or regulation
applicable to the Cayman Islands; |
| (l) | a court may refuse to give effect to a provision in a Document that involves the enforcement of any foreign
revenue or penal laws; |
| (m) | where a contract provides for the payment of legal fees and expenses incurred by a party to that contract
in enforcing the contract, a party who succeeds in enforcing the contract is entitled to recover by court judgment the amount of the legal
fees and expenses found to be due under the terms of the contract. In all other cases, costs of legal proceedings can only be recovered
from another party to the proceedings by a court order, which is a matter for the discretion of the court, and such costs are liable to
taxation (assessment by the court); and |
| (n) | enforcement or performance of any provision in a Document which relates to a Relevant Interest may be
prohibited or restricted if any such Relevant Interest is or becomes subject to a Restrictions Notice. |
7 | A court may determine in its discretion the extent of enforceability of a provision of the a Document
that provides for or requires, as the case may be: |
| (a) | severability of any provision of the Documents held to be illegal or unenforceable; |
| (b) | any calculation, determination or certificate to be conclusive or binding, including if that calculation,
determination or certificate is fraudulent or manifestly inaccurate or has an unreasonable or arbitrary basis; |
| (c) | the vesting in a party of a discretion or of a power to determine a matter in its opinion, if that discretion
is exercised unreasonably or the opinion is not based on reasonable grounds; or |
| (d) | written amendments or waivers of the Documents if a purported amendment or waiver is effected by oral
agreement or course of conduct, |
and we express no opinion on any provisions
of that type.
Zura Bio Limited
3 September 2024
| 8 | The law of the Cayman Islands may not recognise a difference between negligence and gross negligence. |
| 9 | Where any Document is dated “as of” a specific date, although the parties to that Document
have agreed between themselves that, as a matter of contract and to the extent possible, their rights and obligations under it take effect
from a date prior to the date of execution and delivery, that Document still comes into effect on the date it is actually executed and
delivered. Rights of third parties under that Document also take effect from the date that Document is actually executed and delivered,
rather than the “as of” date. |
Public offering in the Cayman Islands
| 10 | The Company is prohibited by section 175 of the Companies Act from making any invitation to the public
in the Cayman Islands to subscribe for any of its securities. |
Exhibit 5.2
Divakar Gupta
+1 212 479 6474
dgupta@cooley.com |
|
September 3, 2024
Zura Bio Limited
1489 W. Warm Springs Rd., #110
Henderson, NV 89014
Ladies and Gentlemen:
We have acted as special U.S. counsel to
Zura Bio Limited, a Cayman Islands exempted company (the “Company”), in connection with the filing by the
Company with the Securities and Exchange Commission (the “Commission”) of a Registration Statement on
Form S-3 (the “Registration Statement”) under the Securities Act of 1933, as amended (the
“Securities Act”). The Registration Statement includes two prospectuses, (i) a base prospectus (the
“Base Prospectus”), and (ii) a sales agreement prospectus (the “Sales Agreement
Prospectus”) covering up to $125,000,000 of the Company’s Class A Ordinary Shares (as defined below) that
may be sold under the Sales Agreement, dated September 3, 2024, between the Company and Leerink Partners LLC (such
agreement, the “Sales Agreement”, and such shares, the “Placement Shares”). The
Base Prospectus provides that it will be supplemented in the future by one or more prospectus supplements (each, a
“Prospectus Supplement”). The Registration Statement, including the Base Prospectus (as supplemented from
time to time by one or more Prospectus Supplements), and the Sales Agreement Prospectus, will provide for the registration by the
Company of the sale of the following securities:
| · | Class A
ordinary shares, par value of US$0.0001 per share, of the Company (the “Class A
Ordinary Shares”); |
| · | preference
shares, par value of US$0.0001 per share, of the Company (the “Preference Shares”); |
| · | debt
securities, in one or more series (the “Debt Securities”), which
may be issued pursuant to an indenture to be dated on or about the date of the first issuance
of Debt Securities thereunder, by and between a trustee to be selected by the Company (the
“Trustee”) and the Company, in the form filed as Exhibit 4.3
to the Registration Statement and one or more indentures supplemental thereto with respect
to any particular series of Debt Securities (the “Indenture”); |
| · | warrants
to purchase Class A Ordinary Shares or Debt Securities (the “Warrants”),
which may be issued under one or more warrant agreements, to be dated on or about the date
of the first issuance of the applicable Warrants thereunder, by and between a warrant agent
to be selected by the Company (the “Warrant Agent”) and the Company,
in the forms to be incorporated by reference as an exhibit to the Registration Statement
(each a “Warrant Agreement”); |
· |
units consisting of any combination of Class A Ordinary Shares, Preference Shares, Debt Securities or Warrants in one or more
series (the “Units”), which may be issued under unit agreements, to be dated on or about the date of the
first issuance of the applicable Units thereunder, by and between a unit agent to be selected by the Company (the “Unit
Agent”) and the Company, in the form to be incorporated by reference as an exhibit to the Registration Statement (the
“Unit Agreement”); and |
The Class A Ordinary Shares, Preference Shares, the Debt Securities,
the Warrants, the Units and the Placement Shares, plus any additional Class A Ordinary Shares, Preference Shares, Debt Securities,
Warrants or Units that may be registered pursuant to any registration statement that the Company may hereafter file with the Commission
pursuant to Rule 462(b) under the Securities Act in connection with an offering by the Company pursuant to the Registration
Statement, are collectively referred to herein as the “Securities.” The Securities are being registered for
offer and sale from time to time pursuant to Rule 415 under the Securities Act.
Cooley
LLP 55 Hudson Yards New York, NY 10001-2157
t: (212) 479-6000 f: (212) 479-6275 cooley.com
Zura Bio Limited
September 3, 2024
Page Two |
|
In connection with this opinion, we have examined
and relied upon the Registration Statement, the Base Prospectus, the Sales Agreement Prospectus and such other records, documents, certificates,
opinions, memoranda and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below.
As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such
matters.
In rendering this opinion, we have assumed the
genuineness of all signatures; the authenticity of all documents submitted to us as originals; the conformity to originals of all documents
submitted to us as copies; the accuracy, completeness and authenticity of certificates of public officials; and the due authorization,
execution and delivery of all documents where authorization, execution and delivery are prerequisites to the effectiveness thereof .
Our opinion herein is expressed solely with respect
to the laws of the State of New York. Our opinion is based on these laws as in effect on the date hereof. We express no opinion as to
whether any particular laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to any federal
or state law, rule or regulation relating to securities, or to the sale or issuance thereof.
We are not hereby rendering any opinion with respect to any Class A
Ordinary Shares or Preference Shares issuable upon the conversion or exercise, as applicable, of any Debt Securities, any Warrants or
any securities that are the components of Units. We have assumed that with respect to any Debt Securities issuable upon the exercise of
any Warrants, the applicable Warrants will be valid and legally binding obligations of the Company. We have also assumed that (i) the
Company is validly existing under the laws of the Cayman Islands, has the corporate power to enter into and perform its obligations under
the Debt Securities, the Indenture, the Warrants and the Units in accordance with their terms, (ii) upon issuance, the Company will
have duly authorized, executed and delivered the Debt Securities, the Indenture, the Warrants and the Units in accordance with its organizational
documents and the laws of the Cayman Islands, (iii) any Class A Ordinary Shares or Preference Shares issued upon conversion
of the Debt Securities, upon exercise of the Warrants or are components of the Units will be duly authorized, validly issued, fully paid
and nonassessable, and (iv) the execution, delivery and performance by the Company of its obligations under the Debt Securities,
the Indenture, the Warrants or the Units will not violate the laws of the Cayman Islands or any other applicable laws (excepting from
such assumption the laws of the State of New York). We have also assumed that any Debt Securities, any Warrants and any Units offered
under the Registration Statement and the related Indenture, Warrant Agreement or Unit Agreement, as applicable, will be executed in the
forms filed as exhibits to the Registration Statement or incorporated by reference therein.
On the basis of the foregoing and in reliance
thereon, and subject to the qualifications herein stated, we are of the opinion that:
1. With
respect to any series of the Debt Securities issued under the Indenture and offered under the Registration Statement, provided that; (i) the
Registration Statement and any required post-effective amendment thereto have become effective under the Securities Act and the Base Prospectus
and any and all Prospectus Supplement(s) required by applicable laws have been delivered and filed as required by such laws; (ii) the
Indenture has been duly authorized by the Company and the Trustee by all necessary corporate action; (iii) the Indenture has been
duly executed and delivered by the Company and the Trustee and has been qualified under the Trust Indenture Act of 1939, as amended; (iv) the
issuance and terms of the Debt Securities, including as to any Class A Ordinary Shares or Preference Shares to be issued on the conversion
thereof, have been duly authorized by the Company by all necessary corporate action; (v) the terms of the Debt Securities and of
their issuance and sale have been duly established in conformity with the Indenture so as not to violate any applicable law or result
in a default under or breach of any agreement or instrument binding upon the Company, so as to be in conformity with the Company’s
then operative memorandum and articles of association (the “Articles”), and so as to comply with any requirement
or restriction imposed by any court or governmental body having jurisdiction over the Company; and (vi) the notes representing the
Debt Securities have been duly executed and delivered by the Company and authenticated by the Trustee pursuant to the Indenture and delivered
against payment therefor, then the Debt Securities, when issued and sold in accordance with the Indenture and a duly authorized, executed
and delivered purchase, underwriting or similar agreement or upon exercise of any Warrants in accordance with their terms, will be binding
obligations of the Company, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws relating
to or affecting creditors’ rights generally, and by general equitable principles (regardless of whether considered in a proceeding
at law or in equity).
Cooley
LLP 55 Hudson Yards New York, NY 10001-2157
t: (212) 479-6000 f: (212) 479-6275 cooley.com
Zura Bio Limited
September 3, 2024
Page Three |
|
2. With
respect to the Warrants issued under the Warrant Agreements and offered under the Registration Statement, provided that (i) the Registration
Statement and any required post-effective amendment thereto have become effective under the Securities Act and the Base Prospectus and
any and all Prospectus Supplement(s) required by applicable laws have been delivered and filed as required by such laws; (ii) the
applicable Warrant Agreement has been duly authorized by the Company and the Warrant Agent by all necessary corporate action; (iii) the
applicable Warrant Agreement has been duly executed and delivered by the Company and the Warrant Agent; (iv) the issuance and terms
of the Warrants, including as to any Class A Ordinary Shares, Preference Shares or Debt Securities to be issued on the exercise thereof,
have been duly authorized by the Company by all necessary corporate action; (v) the terms of the Warrants and of their issuance and
sale have been duly established in conformity with the applicable Warrant Agreement and as described in the Registration Statement, the
Prospectus and the related Prospectus Supplement(s), so as not to violate any applicable law or result in a default under or breach of
any agreement or instrument binding upon the Company, so as to be in conformity with the Articles, and so as to comply with any requirement
or restriction imposed by any court or governmental body having jurisdiction over the Company; and (vi) the Warrants have been duly
executed and delivered by the Company and authenticated by the Warrant Agent pursuant to the applicable Warrant Agreement and delivered
against payment therefor, then the Warrants, when issued and sold in accordance with the applicable Warrant Agreement and a duly authorized,
executed and delivered purchase, underwriting or similar agreement, will be binding obligations of the Company, except as may be limited
by bankruptcy, insolvency, reorganization, moratorium or other similar laws relating to or affecting creditors’ rights generally,
and by general equitable principles (regardless of whether considered in a proceeding at law or in equity).
3. With
respect to the Units issued under the Unit Agreements and offered under the Registration Statement, provided that (i) the Registration
Statement and any required post-effective amendment thereto have become effective under the Securities Act and the Base Prospectus and
any and all Prospectus Supplement(s) required by applicable laws have been delivered and filed as required by such laws; (ii) the
applicable Unit Agreement has been duly authorized by the Company and the Unit Agent by all necessary corporate action; (iii) the
applicable Unit Agreement has been duly executed and delivered by the Company and the Unit Agent; (iv) the issuance and terms of
the Units, including as to any Class A Ordinary Shares, Preference Shares, Debt Securities or Warrants that are components of such Units,
have been duly authorized by the Company by all necessary corporate action; (v) the terms of the Units, including as to any Class
A Ordinary Shares, Preference Shares, Debt Securities or Warrants that are components of such Units, and of their issuance and sale have
been duly established in conformity with the applicable Unit Agreement and as described in the Registration Statement, the Base Prospectus
and the related Prospectus Supplement(s), so as not to violate any applicable law or result in a default under or breach of any agreement
or instrument binding upon the Company, so as to be in conformity with the Articles, and so as to comply with any requirement or restriction
imposed by any court or governmental body having jurisdiction over the Company; and (vi) the Units, including as to any Class A Ordinary
Shares, Preference Shares, Debt Securities or Warrants that are components of such Units, have been duly executed and delivered by the
Company and authenticated by the Unit Agent pursuant to the applicable Unit Agreement and delivered against payment therefor, then the
Units, when issued and sold as contemplated in the Registration Statement, the Base Prospectus and the Prospectus Supplement(s) and
in accordance with the applicable Unit Agreement and a duly authorized, executed and delivered purchase, underwriting or similar agreement,
will be valid and legally binding obligations of the Company, except as may be limited by bankruptcy, insolvency, reorganization, moratorium
or other similar laws relating to or affecting creditors’ rights generally, and by general equitable principles (regardless of whether
considered in a proceeding at law or in equity).
* * * * *
We hereby consent to the filing of this opinion
as an exhibit to the Registration Statement and to the reference to our firm under the caption “Legal Matters” in the Base
Prospectus . We further consent to the incorporation by reference of this opinion into any registration statement filed pursuant to Rule 462(b) under
the Securities Act with respect to additional Securities. In giving such consents, we do not thereby admit that we are in the category
of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.
Our opinion set forth above is limited to the
matters expressly set forth in this letter, and no opinion has been or should be implied or may be inferred beyond the matters expressly
stated. This opinion speaks only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility
to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in
law that may hereafter occur.
Very truly yours,
Cooley
llp
By: |
/s/ Divakar Gupta |
|
|
Divakar Gupta |
|
Cooley
LLP 55 Hudson Yards New York, NY 10001-2157
t: (212) 479-6000 f: (212) 479-6275 cooley.com
Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference
in the Prospectus constituting a part of this Registration Statement on Form S-3 of our report dated March 27, 2024, relating to the
consolidated financial statements of Zura Bio Limited as of and for the year ended December 31, 2023, and the period from January 18,
2022 (date of inception) to December 31, 2022, which is incorporated by reference in the Prospectus.
We also consent to the reference to us under
the caption “Experts” in the Prospectus.
/s/ WithumSmith+Brown, PC
East Brunswick, New Jersey
September 3, 2024
Exhibit 107
Calculation of Filing Fee Tables
Form S-3
(Form Type)
Zura Bio Limited
(Exact Name of Registrant as Specified in its Charter)
Table 1: Newly Registered and Carry Forward
Securities
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Security
Type |
|
Security
Class
Title |
|
Fee
Calculation
or Carry
Forward
Rule |
|
Amount
Registered |
|
Proposed
Maximum
Offering
Price Per
Unit |
|
Maximum
Aggregate
Offering
Price |
|
Fee
Rate |
|
Amount of
Registration
Fee |
|
Carry
Forward
Form
Type |
|
Carry
Forward
File
Number |
|
Carry
Forward
Initial
effective
date |
|
Filing Fee
Previously
Paid In
Connection
with
Unsold
Securities
to
be Carried
Forward |
|
Newly
Registered Securities |
|
|
|
|
|
|
|
|
|
|
|
|
|
Fees to Be
Paid |
|
Debt |
|
Debt
Securities |
|
Rule 457(o) |
|
(1) |
|
(2) |
|
(2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Equity |
|
Class A
Ordinary Shares, par value $0.0001 per share |
|
Rule 457(o) |
|
(1) |
|
(2) |
|
(2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Equity |
|
Preference
Shares, par value $0.0001 per share |
|
Rule 457(o) |
|
(1) |
|
(2) |
|
(2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Other |
|
Warrants |
|
Rule 457(o) |
|
(1) |
|
(2) |
|
(2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Other |
|
Units |
|
Rule 457(o) |
|
(1) |
|
(2) |
|
(2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total |
|
n/a |
|
Rule 457(o)
|
|
n/a |
|
Unallocated
(Universal)
Shelf |
|
$300,000,000 |
|
$0.0001476 |
|
$44,280(3) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fees
Previously
Paid |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry
Forward Securities |
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry
Forward
Securities |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total
Offering Amounts |
|
|
|
$300,000,000 |
|
$0.0001476 |
|
$44,280 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total
Fees Previously Paid |
|
|
|
|
|
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total
Fee Offsets |
|
|
|
|
|
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net
Fee Due |
|
|
|
|
|
|
|
$44,280 |
|
|
|
|
|
|
|
|
(1) |
The amount to be registered consists of up to $300,000,000 of an indeterminate amount of Class A ordinary shares, preference shares, debt securities, warrants and/or units. There is also being registered hereunder such currently indeterminate number of (i) Class A ordinary shares or other securities of the registrant as may be issued upon conversion of, or in exchange for, convertible or exchangeable preference shares and/or debt securities registered hereby, or (ii) Class A ordinary shares, preference shares, or debt securities as may be issued upon exercise of warrants registered hereby, as the case may be. Any securities registered hereunder may be sold separately or as units with the other securities registered hereunder. If any debt securities are issued at an original issue discount, then the principal amount of such debt securities shall be in such greater amount as shall result in an aggregate initial offering price not to exceed $300,000,000, less the aggregate dollar amount of all securities previously issued hereunder. |
(2) |
The proposed maximum aggregate offering price per unit will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder and is not specified as to each class of security pursuant to Instruction 2.A.iii.b. to the Calculation of Filing Fee Tables and Related Disclosure on Item 16(b) of Form S-3 under the Securities Act. |
(3) |
Estimated solely for purposes of computing the registration fee pursuant to Rule 457(o) under the Securities Act of 1933, as amended. In no event will the aggregate offering price of all securities sold by the registrant from time to time pursuant to this registration statement exceed $300,000,000. No separate consideration will be received for (i) Class A ordinary shares or other securities of the registrant that may be issued upon conversion of, or in exchange for, convertible or exchangeable preferences shares and/or debt securities registered hereby, or (ii) Class A ordinary shares, preference shares or debt securities that may be issued upon exercise of warrants registered hereby, as the case may be. |
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