As filed with the Securities and Exchange Commission on August 21,
2024
Registration No. 333-_________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
APREA THERAPEUTICS, INC.
(Exact name of registrant as specified in its
charter)
Delaware |
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84-2246769 |
(State or other jurisdiction
of incorporation or organization) |
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(I.R.S. Employer Identification
No.) |
3805 Old Easton Road
Doylestown, PA |
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18902 |
(Address of Principal Executive
Offices) |
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(Zip Code) |
Aprea Therapeutics, Inc. 2019 Equity Incentive
Plan
Non-Plan Inducement Stock Option Grant
Non-Plan Inducement Restricted Stock Unit Award
(Full title of the plan)
Oren Gilad, Ph.D.
President and Chief Executive Officer
3805 Old Easton Road
Doylestown, PA 18902
(617) 463-9385
(Name, address and telephone number, including
area code, of agent for service)
Copies
to:
Fahd M.T. Riaz, Esq.
DLA Piper LLP (US)
One Liberty Place
1650 Market Street, Suite 5000
Philadelphia, PA 19103-7300
(215) 656-3316
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large
accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange
Act.
Large Accelerated filer ¨ |
Accelerated filer ¨ |
Non-accelerated filer x |
Smaller reporting company x |
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Emerging growth company x |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. x
REGISTRATION OF ADDITIONAL
SECURITIES
EXPLANATORY NOTE
Aprea
Therapeutics, Inc. (the “Registrant”) is filing this registration statement on Form S-8 (the
“Registration Statement”) with the Securities and Exchange Commission (the “SEC”) for the purpose of
registering 149,466 shares (the “Shares”) of the Registrant’s common stock, par value $0.001 per share (the
“Common Stock”) that may be issued pursuant to equity awards granted pursuant to the Aprea Therapeutics, Inc. 2019
Equity Incentive Plan (in the form attached hereto as Exhibit 99.1) (the “2019 Plan”). The Shares are securities of
the same class as other securities for which registration statements of the Registrant filed with the Securities and Exchange
Commission on November 18, 2019 (Registration No. 333-234765), November 12, 2020 (Registration No. 333-250043), November 9, 2021 (Registration No. 333-260884), December 15, 2022 (Registration No. 333-268816) and November 9, 2023 (Registration No. 333-275440).
In
accordance with General Instruction E of Form S-8, the contents of the Registrant’s registration statements filed with the
Securities and Exchange Commission on November 18, 2019 (Registration No. 333-234765), November 12, 2020 (Registration No. 333-250043), November 9, 2021 (Registration No. 333-260884), December 15, 2022 (Registration No. 333-268816)
and November 9, 2023 (Registration No. 333-275440 are incorporated herein by reference (solely to the extent the contents of
such registration statements relate to the 2019 Plan) and the information required by Part II is omitted, except as supplemented
by the information set forth below.
This Registration Statement is also filed for
the purpose of registering an aggregate of 33,650 shares of Common Stock comprised of:
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26,920 shares of Common
Stock issuable upon the exercise of an inducement stock option grant, and |
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6,730
shares of Common Stock issuable upon the vesting of an inducement restricted stock unit award, |
each granted to Nadeem Q. Mirza, M.D., M.P.H.,
as an inducement for his acceptance of employment with the Registrant as its Chief Medical Officer (collectively, the “Inducement
Awards”). The Inducement Awards were granted outside of the Registrant’s 2019 Plan pursuant to the “inducement”
grant exception under Nasdaq Listing Rule 5635(c)(4) and have been approved by the Registrant’s Board of Directors.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Information required by Part I of Form S-8
to be contained in the Section 10(a) prospectus is omitted from this Registration Statement in accordance with Rule 428
under the Securities Act of 1933, as amended (the “Securities Act”). The document(s) containing the information specified
in Part I will be sent or given to the participant in the Inducement Awards pursuant to Rule 428(b)(1). Such document(s) are
not being filed with the SEC as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424
of the Securities Act. These document(s) and the documents incorporated by reference in the Registration Statement pursuant to Item
3 of Part II of this form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the
Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents filed by the Registrant
with the Commission are hereby incorporated by reference into this Registration Statement:
(a) |
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The Registrant’s
Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Commission on March 26,
2024; |
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(b) |
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The Registrant’s
Current Reports on Form 8-K filed with the Commission on January 4,
2024, January 26,
2024, February 6,
2024, March 12,
2024 (other than the information furnished pursuant to Item 7.01), and March 26,
2024 (other than the information furnished pursuant to Item 2.02), April 10,
2024, May 14,
2024 (other than the information furnished pursuant to Item 2.02), June 17,
2024, and June 20,
2024; , and August 12, 2024 (other than the information furnished pursuant to Item 2.02) and |
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(c) |
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The Registrant’s
information specifically incorporated by reference in the 2023 10-K from the Registrant’s definitive proxy statement on Schedule 14A for the 2024 annual meeting of stockholders, filed with the SEC on April 25, 2024; |
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(d) |
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The Registrant’s
Quarterly Reports on Form 10-Q for the quarter ended March 31, 2024 filed with the SEC on May 15, 2024; |
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(e) |
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The Registrant’s Quarterly Reports on Form 10-Q for the quarter ended June 30, 2024 filed with the SEC on August 12, 2024; and |
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(f) |
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The description of the
Common Stock set forth in the Registrant’s Registration Statement on Form 8-A (File No. 001-39069), filed with the Commission on September 30, 2019, including any amendments or reports filed for the purpose of updating such description. |
All other reports and documents
subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports
furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the
date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates
that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated
by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for
purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also
is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
Section 102 of the Delaware
General Corporation Law permits a corporation to eliminate the personal liability of its directors for monetary damages for a breach
of fiduciary duty as a director, except where the director breached his or her duty of loyalty, failed to act in good faith, engaged
in intentional misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in violation
of Delaware corporate law or obtained an improper personal benefit. Our certificate of incorporation provides that none of our directors
shall be personally liable to us or our stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding
any provision of law imposing such liability, except to the extent that the Delaware General Corporation Law prohibits the elimination
or limitation of liability of directors for breaches of fiduciary duty.
Section 145 of the Delaware
General Corporation Law provides that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation
and certain other persons serving at the request of the corporation in related capacities against expenses (including attorneys’
fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by the person in connection with an action,
suit or proceeding to which he or she is or is threatened to be made a party by reason of such position, if such person acted in good
faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal
action or proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that, in the case of actions brought
by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to which such person
shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or other adjudicating
court determines that, despite the adjudication of liability but in view of all of the circumstances of the case, such person is fairly
and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.
Our certificate of incorporation
provides that we will indemnify each person who was or is a party or is threatened to be made a party or is involved in any threatened,
pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or
in the right of us) by reason of the fact that he or she is or was, or has agreed to become, our director or officer, or is or was serving,
or has agreed to serve, at our request as a director, officer, partner, employee or trustee of, or in a similar capacity with, another
corporation, partnership, joint venture, trust or other enterprise (all such persons being referred to as an “Indemnitee”),
or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding and
any appeal therefrom, if such Indemnitee acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to,
our best interests, and, with respect to any criminal action or proceeding, he or she had no reasonable cause to believe his or her conduct
was unlawful. Our certificate of incorporation also provides that we will indemnify any Indemnitee who was or is a party to an action
or suit by or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee is or was, or has agreed
to become, our director or officer, or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee
or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise, or by reason
of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees) and, to
the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding,
and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably believed to be in, or not opposed
to, our best interests, except that no indemnification shall be made with respect to any claim, issue or matter as to which such person
shall have been adjudged to be liable to us, unless a court determines that, despite such adjudication but in view of all of the circumstances,
he or she is entitled to indemnification of such expenses. Notwithstanding the foregoing, to the extent that any Indemnitee has been
successful, on the merits or otherwise, he or she will be indemnified by us against all expenses (including attorneys’ fees) actually
and reasonably incurred by him or her or on his or her behalf in connection therewith. If we do not assume the defense, expenses must
be advanced to an Indemnitee under certain circumstances.
We have entered into indemnification
agreements with each of our executive officers and directors. In general, these agreements provide that we will indemnify the director
or executive officer to the fullest extent permitted by law for claims arising in his or her capacity as a director or executive officer
of our company or in connection with their service at our request for another corporation or entity. The indemnification agreements also
provide for procedures that will apply in the event that a director or executive officer makes a claim for indemnification and establish
certain presumptions that are favorable to the director or executive officer.
We maintain a general liability
insurance policy that covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their
capacities as directors or officers.
The underwriting agreement, to be filed by an
amendment to this registration statement, will provide for indemnification of us and our directors and officers by the underwriters against
certain liabilities under the Securities Act and the Exchange Act.
Insofar as the forgoing provisions
permit indemnification of directors, executive officers, or persons controlling us for liability arising under the Securities Act of
1933, as amended, or the Securities Act, we have been informed that, in the opinion of the Securities and Exchange Commission, such indemnification
is against public policy as expressed in the Securities Act and is therefore unenforceable.
Item 7. Exemption from Registration Claimed.
Not applicable.
Exhibit
No. |
Description |
4.1 |
Amended and Restated Certificate
of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K,
filed with the Commission on October 7, 2019) |
4.2 |
Certificate of Amendment
to Amended and Restated Certificate of Incorporation of Aprea Therapeutics, Inc. (incorporated by reference to Exhibit 3.1
to the Current Report on Form 8-K filed on February 13, 2023) |
4.3 |
Certificate of Designation
of Series A Non-Voting Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Current
Report on Form 8-K filed on May 17, 2022) |
4.4 |
Amended and Restated Bylaws
of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the quarter
ended September 30, 2020, filed with the Commission on November 6, 2020) |
5.1* |
Opinion of DLA Piper LLP (US) |
23.1* |
Consent of EisnerAmper LLP |
23.2* |
Consent of DLA Piper LLP (US) (included in Exhibit 5.1) |
23.3* |
Consent of Ernst & Young LLP. |
24 |
Power of Attorney (contained on the signature page hereto) |
99.1 |
Aprea Therapeutics, Inc. 2019 Equity Incentive
Plan (incorporated by reference to Exhibit 10.1 to the Registrant’s Registration Statement (Form S-1/A), filed with
the Commission on September 27, 2019) |
99.2 |
Aprea Therapeutics, Inc.
Inducement Stock Option Agreement, dated May 1, 2024, by and between Aprea Therapeutics, Inc. and Nadeem Q. Mirza, M.D.,
M.P.H. (incorporated by reference to Exhibit 10.5 to the Registrant's Quarterly Report on Form 10-Q for the quarter ended
March 31, 2024, filed with the Commission on May 14, 2024) |
99.3 |
Aprea Therapeutics, Inc.
Inducement Restricted Stock Unit Award Agreement, dated May 1, 2024, by and between Aprea Therapeutics, Inc. and Nadeem
Q. Mirza, M.D., M.P.H. (incorporated by reference to Exhibit 10.6 to the Registrant's Quarterly Report on Form 10-Q for
the quarter ended March 31, 2024, filed with the Commission on May 14, 2024) |
107* |
Filing Fee Table |
Item 9. Undertakings.
(a)
The undersigned Registrant hereby undertakes:
(1) To file, during any period in which
offers or sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus
required by section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus
any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered
would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be
reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in
volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the “Calculation
of Registration Fee” table in the effective registration statement; and
(iii) To include any material
information with respect to the plan of distribution not previously disclosed in this registration statement or any material change to
such information in this registration statement; provided, however, that subparagraphs (i), (ii) and (iii) do not apply if
the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished
to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated
by reference in this registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is
part of the registration statement.
(2) That, for the purpose of determining
any liability under the Securities Act, each such post effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.
SIGNATURE
Pursuant to the requirements
of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Doylestown, Commonwealth of Pennsylvania, on August 21, 2024.
Aprea Therapeutics, Inc. |
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By: |
/s/ Oren Gilad |
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Name: |
Oren Gilad, Ph.D. |
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Title: |
President and Chief Executive Officer |
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POWER OF ATTORNEY
The officers and directors
of Aprea Therapeutics, Inc. whose signatures appear below hereby constitute and appoint Oren Gilad and John Hamill, and each of
them, their true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute
on behalf of the undersigned this Registration Statement on Form S-8, and any amendment or amendments thereto, and each of the undersigned
does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements
of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date
indicated.
Signature |
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Title |
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Date |
/s/ Oren Gilad |
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President, Chief Executive
Officer and Director |
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August 21, 2024 |
Oren Gilad, Ph.D. |
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(Principal Executive Officer) |
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/s/ John P.
Hamill |
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Senior Vice President, Chief
Financial Officer |
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August 21, 2024 |
John P. Hamill |
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(Principal Financial and
Accounting Officer) |
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/s/ Marc Duey |
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Director |
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August 21, 2024 |
Marc Duey |
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/s/ Michael
Grissinger |
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Director |
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August 21, 2024 |
Michael Grissinger |
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/s/ John B.
Henneman |
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Director |
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August 21, 2024 |
John B. Henneman III |
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/s/ Rifat Pamukcu |
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Director |
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August 21,
2024 |
Rifat Pamukcu, M.D. |
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/s/ Richard
Peters |
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Director |
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August 21,
2024 |
Richard Peters, M.D., Ph.D. |
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/s/ Gabriel
Gruia |
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Director |
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August 21,
2024 |
Gabriel Gruia, M.D. |
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/s/ Bernd Seizinger |
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Director |
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August 21,
2024 |
Bernd R. Seizinger, M.D., Ph.D. |
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/s/ Jean-Pierre
Bizzari |
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Director |
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August 21,
2024 |
Jean-Pierre Bizzari, M.D. |
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Exhibit 5.1
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DLA Piper LLP (US)
One Liberty Place
1650 Market Street, Suite 5000
Philadelphia, PA 19103-7300
www.dlapiper.com |
August 21, 2024
Aprea Therapeutics, Inc.
3805 Old Easton Road
Doylestown, PA 18902
RE: Aprea Therapeutics, Inc.
- Registration Statement on Form S-8
Ladies and Gentlemen:
We
have acted as counsel to Aprea Therapeutics, Inc., a Delaware corporation (the “Company”), in connection
with the filing by the Company of a Registration Statement on Form S-8 (the “Registration Statement”) with
the Securities and Exchange Commission (the “Commission”) covering the offering of up to 149,466 shares (the
“Plan Shares”) of the Registrant’s common stock, par value $0.001 per share (the “Common Stock”)
that may be issued pursuant to equity awards granted pursuant to the Aprea Therapeutics, Inc. 2019 Equity Incentive Plan and
33,650 shares (the “Inducement Shares”) of the Company’s Common Stock consisting of (a) 26,920 shares
of Common Stock issuable upon the exercise of a stock option grant and (b) 6,730 shares of Common Stock issuable upon the vesting
of a restricted stock unit award to be granted as inducement awards by the Company (the “Inducement Awards”).
In connection with this opinion, we have examined
and relied upon (a) the Registration Statement and related prospectus, (b) the documents evidencing the Inducement Awards, (c) the
Company’s certificate of incorporation and bylaws, each as currently in effect, and (d) such other records, documents, opinions,
certificates, memoranda and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below.
We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to originals
of all documents submitted to us as copies, the accuracy, completeness and authenticity of certificates of public officials, and the due
authorization, execution and delivery of all documents by all persons other than the Company where authorization, execution and delivery
are prerequisites to the effectiveness thereof. As to certain factual matters, we have relied upon a certificate of an officer of the
Company and have not independently verified such matters.
Our opinion is expressed only with respect to the
General Corporation Law of the State of Delaware. We express no opinion to the extent that any other laws are applicable to the subject
matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or
regulation.
On the basis of the foregoing, and in reliance
thereon, we are of the opinion that the Plan Shares have been duly authorized and, when and to the extent issued in accordance with the
terms of the Plan and any award agreement entered into under the Plan, the Plan Shares will be validly issued, fully paid and nonassessable,
and that the Inducement Shares, when issued in accordance with the terms of Inducement Awards, the Registration Statement and the related
prospectus, will be validly issued, fully paid, and nonassessable (except as to shares issued pursuant to deferred payment arrangements,
which will be fully paid and nonassessable when such deferred payments are made in full).
This opinion is limited to the matters expressly
set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated. This
opinion speaks only as to law and facts in effect or existing as of the date hereof and we have no obligation or responsibility to update
or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in law that may
hereafter occur.
We consent to the filing of this opinion as an
exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent
is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.
Very truly yours, |
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/s/ DLA Piper LLP (US) |
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Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in this Registration Statement
of Aprea Therapeutics, Inc. on Form S-8 to be filed on or about August 12, 2024 of our report dated March 26, 2024,
on our audit of the financial statements as of December 31, 2023 and for the year then ended, which report was included in the Annual
Report on Form 10-K filed March 26, 2024.
/s/ EisnerAmper LLP
EISNERAMPER LLP
Philadelphia, Pennsylvania
August 21, 2024
Exhibit 23.3
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8) of our report dated March 30, 2023, with respect
to the consolidated financial statements of Aprea Therapeutics, Inc. for the fiscal years ending 2022 and 2021 included in its Annual
Report (Form 10-K) for the year ended December 31, 2023, filed with the Securities and Exchange Commission.
/s/ Ernst &
Young LLP
Iselin, New Jersey
August 21, 2024
Exhibit 107
Calculation of Filing Fee Table
Form S-8
Aprea Therapeutics, Inc.
Table 1: Newly Registered Securities
Security
Type |
Security Class
Title |
Fee
Calculation
Rule |
Amount
Registered(1) |
Proposed
Maximum
Offering
Price Per
Unit(2) |
Maximum
Aggregate
Offering
Price(2) |
Fee Rate |
Amount of
Registration
Fee |
Equity |
Common stock, par value $0.001 |
Rule 457(c)
and Rule
457(h) |
149,466(5) |
$3.505 |
$523,878.33 |
0.00014760 |
$77.32 |
Equity |
Common stock, $0.001 par value per share, Non-Plan Inducement Stock Option Grant |
Other(2) |
26,920(3) |
$3.505 |
$94,354.60 |
0.00014760 |
$13.93 |
Equity |
Common stock, $0.001 par value per share, Non-Plan Inducement Restricted Stock Unit Award |
Other(2) |
6,730(4) |
$3.505 |
$23,588.65 |
0.00014760 |
$3.48 |
Total Offering Amounts |
|
$641,821.58 |
|
$94.73 |
Total Fee Offsets |
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|
— |
Net Fee Due |
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$94.73 |
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(1) |
Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of common stock, $0.001 par value per share (“Common Stock”), of Aprea Therapeutics, Inc. (the “Registrant”) that become issuable pursuant to the non-plan inducement stock option grant and the non-plan inducement restricted stock unit award set forth herein by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of Common Stock, as applicable. |
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(2) |
Estimated in accordance with Rule 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $3.505 per share of Common Stock, the average of the high and low prices of the Common Stock as reported on The Nasdaq Capital Market on August 16, 2024, a date that is within five business days prior to the date on which this Registration Statement is being filed. |
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(3) |
Represents shares of Common Stock reserved for issuance upon the exercise of a stock option to be granted outside the Registrant’s 2019 Equity Incentive Plan (the “2019 Plan”) as an inducement grant pursuant to Nasdaq Listing Rule 5635(c)(4). |
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(4) |
Represents shares of Common Stock reserved for issuance upon the vesting of a restricted stock unit award to be granted outside the 2019 Plan as an inducement grant pursuant to Nasdaq Listing Rule 5635(c)(4). |
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(5) |
Consists of shares of Common Stock under the 2019 Plan. |
Aprea Therapeutics (NASDAQ:APRE)
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