Adagene Inc (ADAG) ニュース

ADAG the monster won’t stop

ADAG..monster bio ready to roar

ADAG new 52 week high

ADAG...HERE WE GO

adag next bio monster

ADAG new 52 week high

ADAG new 52 week high

ADAG new 52 week high

ADAG under $2

The PR headline is a false implication:

“4:13a ET 9/10/2022 - Globe Newswire
Adagene Presents Interim Monotherapy Data at ESMO 2022 Showing Compelling Safety, Anti-Tumor Activity and Pharmacokinetics of Masked, Anti-CTLA-4 SAFEbody(R) ADG126 in Patients with Advanced Tumors”

Yes technically a couple of patients had anti-tumor activity, but the headline can easily be misconstrued and read at first glance to infer that all patients had that positive reaction. The headline should be clear, naming the exact number of patients who experienced tumor reduction out of the total number of patients, if they want to claim that a build up of ADG in the tumors is anti-tumor activity then that is different “activity” than tumor reduction, if I paint mayonnaise every day on non-reducing tumors of a patient over the course of 6 months, mayonnaise would also safely show up in trial results accumulating in the area.

Company is trying to use manipulative language to pass their overall failure, so far, off as success, calling the results “intriguing”, “anti-tumor activity” implying falsely that it was across all patients, as if all the patients had anti-tumor activity when that isn’t what is reported below that verbiage in the PR, gotta critically read the PR to see how they wrote it,
Deceiving PR imo, prime example, this statement falsely implies that all patients hand this positive reaction while also being “technically true” so as not to be called out for the implication,‘can you detect the deceptive language ?

"ADG126 continues to demonstrate a remarkable safety profile, highly differentiated from both the currently approved anti-CTLA-4 therapy and others in development, as well as antitumor activity in heavily pre-treated patients with cold tumors,"

“4:13a ET 9/10/2022 - Globe Newswire
Adagene Presents Interim Monotherapy Data at ESMO 2022 Showing Compelling Safety, Anti-Tumor Activity and Pharmacokinetics of Masked, Anti-CTLA-4 SAFEbody(R) ADG126 in Patients with Advanced Tumors

EQNX::TICKER_START (NasdaqGM:ADAG), EQNX::TICKER_END - Best-in-class profile demonstrated with repeat dosing across dose levels -

- Antitumor activity observed in cold tumors with steady accumulation of activated ADG126 -

- On track in 2022 to report results of ADG126 dose escalation in combination with anti-PD-1 therapy, establishing dose regimen for phase 2a dose expansion cohorts -

Adagene Inc. ("Adagene") (Nasdaq: ADAG), a company transforming the discovery and development of novel antibody-based therapies, today announced the publication of data showing the best-in-class potential of ADG126, a masked, anti-CTLA-4 SAFEbody(R). Interim results from the Phase 1 portion of an ongoing Phase 1b/2 trial of ADG126 are being presented at the European Society for Medical Oncology (ESMO) Congress 2022 in Paris, September 9 - 13, 2022.

The poster, titled "Phase 1 Results Demonstrate Highly Differentiated Safety and PK Profile of ADG126, a Masked anti-CTLA-4 SAFEbody(R) in Patients with Advanced Solid Tumors," reviewed data from the first-in-human, open label, phase 1 dose-escalation and dose expansion. The poster reports data on 26 patients with advanced metastatic solid tumors, the majority (58%) of whom received three or more lines of prior therapies and nearly half (42%) of whom progressed from prior immuno-oncology (IO) therapy.

Key findings include:

-- Safety: ADG126 monotherapy showed an unprecedented clinical safety profile at dosing levels up to 20 mg/kg when administered to this heavily pretreated patient population once every three weeks. ADG126 was well tolerated, with no dose-limiting toxicities or treatment-related Grade 3 or higher adverse events observed. The most frequent treatment related adverse events (TRAEs) (greater-than or equal to10%) were fatigue (12%), pruritis (12%), rash (12%) and diarrhea (12%). Dose escalation is completed at 20 mg/kg and dose expansion is ongoing at 10 mg/kg.

-- Antitumor Activity in Cold Tumors: With 18 cycles of treatment at 1 mg/kg, an ovarian cancer patient experienced significant, continued reduction of an established ovarian cancer biomarker, CA125, dropping 90% to within the normal range for full clinical benefit. As of cycle 16, the patient experienced a 22% decrease in target lesions. Previously, this patient had surgery and five prior lines of systemic therapies. At the data cut-off of August 17, 2022, the disease control rate was 39% (9/23 evaluable patients).

-- Pharmacokinetics: ADG126 plasma pharmacokinetics (PK) were approximately linear and activated ADG126 accumulated steadily during repeat dosing across different dose levels. This suggests prolonged exposures of activated ADG126 in the tumor microenvironment (TME), with cleaved ADG126 on average accumulating greater-than or equal to3-fold during repeat dosing, resulting from an approximately 1.5-fold longer half-life of total ADG126 compared with its parental antibody.

"ADG126 continues to demonstrate a remarkable safety profile, highly differentiated from both the currently approved anti-CTLA-4 therapy and others in development, as well as antitumor activity in heavily pre-treated patients with cold tumors," said Dr. Gary Richardson, OAM, MBBS, FRACP, Group Director at Cabrini Health Research, Neil Beauglehall Endowed Chair, Medical Oncology Research, and Professor of Medicine at Monash University, Australia, said, "An intriguing case study of our poster is the experience of a patient with ovarian cancer, whose tumor reduced by 22 percent accompanied by normalization of an established clinical biomarker, CA125, dropping by tenfold after more than one year of treatment with ADG126 administered every three weeks at only 1 mg/kg. These data clearly demonstrate the monotherapy activity of this novel antibody, ADG126, supporting its ongoing evaluation as both monotherapy and in combination with anti-PD-1 agents."

Trials evaluating the combination of ADG126 and anti-PD-1 therapies are ongoing in patients with advanced, metastatic tumors in the US, China and Asia Pacific (APAC), evaluating optimized doses of ADG126 in targeted tumors.

ADG126 SAFEbody applies precision-masking technology to the parental anti-CTLA-4 antibody, ADG116, for conditional activation in the TME to expand the therapeutic index and further address safety concerns with existing CTLA-4 therapies. Binding to the same unique epitope as ADG116, the masked ADG126 is designed to provide enhanced safety and efficacy profiles due to the combination of the potent Treg depletion in the TME and partial ligand blocking by the activated ADG126, which is accumulated steadily for the prolonged tumor killing effect in TME.”

Results not good: 2 out of 26 success rate

“ -- Antitumor Activity in Cold Tumors: With 18 cycles of treatment at 1 mg/kg, an ovarian cancer patient experienced significant, continued reduction of an established ovarian cancer biomarker, CA125, dropping 90% to within the normal range for full clinical benefit. As of cycle 16, the patient experienced a 22% decrease in target lesions. Previously, this patient had surgery and five prior lines of systemic therapies. At the data cut-off of August 17, 2022, the disease control rate was 39% (9/23 evaluable patients).”

Lipstick on a pig (poster), so far. While it is great that one person got better and safety profile was great, A 1/26 success rate (what they call their case study) isn’t good enough imo. From March until August 17 the disease was controlled in 9/23 patients, not good enough yet imo with only one or two reductions in tumors out of all the dosed patients.

Todays PR is a repeat of the August 30 PR, word for word, except that it was on a poster at a conference:

“ -- Compelling clinical safety demonstrated at unprecedented dosing levels with repeat dosing: -- Completed monotherapy dose escalation of ADG126 in 19 patients up to 20 mg/kg administered every three weeks with repeat dosing, and continued to enroll patients in dose expansion at 10 mg/kg. -- ADG126 monotherapy was well tolerated with no dose-limiting toxicities or treatment-related serious adverse events observed following repeat dosing across all dose levels, as reported in an abstract at the 2022 American Society of Clinical Oncology annual meeting. -- Clinical evaluation with anti-PD-1 therapies is ongoing to establish the dose and schedule for phase 2 combination cohorts. In combination cohorts with toripalimab, the safety review committee has cleared the 6 mg/kg dose administered every three weeks, approved dose expansion at 6 mg/kg, and recommended further dose escalation to 10 mg/kg, the highest dose level ever reported for the combination of anti-CTLA-4 and anti-PD-1 therapies. -- Encouraging antitumor activity observed as monotherapy in cold tumors: -- In a cohort of heavily pre-treated patients, ADG126 monotherapy resulted in durable reductions in target lesions over 20% in two patients with cold tumors: -- One ovarian cancer patient who experienced significant, continued reduction of an established ovarian cancer biomarker, CA125, dropping 90% to within the normal range for full clinical benefit after receiving up to 18 cycles of treatment at 1 mg/kg, as of this release. -- One uveal melanoma patient who received prior immuno-oncology treatment, having progressed after the combination of nivolumab and ipilimumab. -- Updated interim results will be presented in a poster on September 12 at the European Society for Medical Oncology (ESMO) Congress 2022 in Paris, September 9 -- 13, 2022 -- Both monotherapy and combination trials continue to enroll patients with advanced, metastatic tumors in the US, China and APAC, evaluating optimized doses of ADG126 in targeted tumors. -- Pharmacokinetics show effectiveness of precision masking technology: -- In monotherapy evaluation, ADG126 plasma pharmacokinetics (PK) were approximately linear and activated ADG126 accumulated steadily during repeat dosing across different dose levels. -- This reflects prolonged exposures of activated ADG126 in the tumor microenvironment (TME), with cleaved ADG126 in plasma on average accumulating >2-fold during repeat dosing. ”

-Dow Jones Newswires

August 30, 2022 17:25 ET (21:25 GMT)

Fill gap at $1.38 in the short term, nothing new to be presented this weekend imo

A DAG



Gene-try

They have enough funding till late 2024, they have non-dilutive revenue and opportunities for more non-dilutive revenue, they have promising drugs in the pipeline that have exhibited safety and efficacy and they have a buyback in progress and charts which have completely consolidated: 1 month, 3 months, 6 months, 1 year and 5 year charts all ready to go. Perfect opportunity by any and all measures imo. From 31.83 to 1.46 in 18 months, down 97%:, Assets:Liabilities 3:1.

"5:25p ET 8/30/2022 - Dow Jones
Press Release: Adagene Reports Financial Results for the Six Months Ended June 30, 2022 and Provides Corporate Updates

Adagene Reports Financial Results for the Six Months Ended June 30, 2022 and Provides Corporate Updates

-- Topline data for anti-CTLA-4 antibody, ADG116, shows compelling clinical safety and complete and partial responses as both a single agent and in combination with anti-PD-1 therapy; results to be presented at SITC 2022 --

-- Masked, anti-CTLA-4 antibody, ADG126, safely dosed repeatedly up to 20 mg/kg as a single agent with encouraging efficacy signals; results to be presented at ESMO 2022 --

-- Presentation of combination dosing data with anti-PD-1 therapies in 2022, while dose expansion begins for both ADG116 and ADG126 in targeted tumors --

-- Submitted regulatory filing for clinical trial of masked, IgG1-based anti-CD137 candidate, ADG206, with greater preclinical potency than the analog of a benchmark antibody, urelumab, that demonstrated monotherapy efficacy in clinic; patient dosing planned in early 2023 --

-- Cash balance of US$168 million supports streamlined operations into late 2024, with planned key readouts in 2023 for anti-CTLA-4 and anti-PD-1 combination therapies expected to pave way for pivotal trials --

-- Technology licensing collaborations provide near-term revenue opportunity --

SAN DIEGO and SUZHOU, China, Aug. 30, 2022 (GLOBE NEWSWIRE) -- Adagene Inc. ("Adagene") (Nasdaq: ADAG), a platform-driven, clinical-stage biotechnology company transforming the discovery and development of novel antibody-based therapies, today reported financial results for the six months ended June 30, 2022 and provided corporate updates.

"We are prioritizing development of two anti-CTLA-4 antibodies, which have best-in-class profiles and are on track to deliver proof-of-concept clinical results in combination therapy in 2023. Anti-CTLA-4 therapy is known for dose dependent toxicity, making it extremely difficult to optimize dosing levels, dosing frequency and dosing intervals for prevailing anti-CTLA-4 therapy, especially in combination therapy with anti-PD-1. We have solved this problem with differentiated candidates suitable for the massive market opportunity for next generation anti-CTLA-4 therapies, increasing market penetration into known and new indications with enhanced safety and efficacy, especially for tumor types not addressed with the currently available therapy, and rapid entry into new markets such as China with few approved indications for anti-CTLA-4 in combination with widely accessible anti-PD-1 therapy," said Peter Luo, Ph.D., Co-founder, Chief Executive Officer and Chairman of Adagene. "We are also excited to advance our next generation anti-CD137 agonistic antibody, ADG206, into clinic given its first- and best-in-class potential in both monotherapy and in combination with multiple agents."

Dr. Luo continued: "On the longer-term horizon, we have developed a portfolio of masked, bispecific T cell engagers (TCEs) for tumor directed T cell therapies, armed with proprietary, tailor-made anti-CD3 and CD28 by leveraging our NEObody(TM) and SAFEbody(R) technologies, that aim to push the boundaries of what is possible with TCEs -- to achieve safe, potent and durable responses for patients by combining our novel modalities with the fundamental pathways across the cancer immunity cycle."

He concluded: "Building on success of existing technology licensing deals, we are also pursuing additional collaboration agreements that leverage our pipeline, our integrated AI-powered antibody discovery platform, and our SAFEbody precision masking technology, to bring potential non-dilutive funding to Adagene. We believe that the combination of our proprietary technology platforms and our highly differentiated clinical and preclinical pipelines presents us with many value-creating levers to navigate today's turbulent financial markets."

PIPELINE & BUSINESS HIGHLIGHTS

ADG116 (anti-CTLA-4 NEObody(TM) targeting a unique epitope)
-- Encouraging efficacy demonstrated as a single agent and in combination with anti-PD-1: -- Observed one partial response with ADG116 monotherapy in a tumor type where no anti-CTLA-4 therapy is currently approved. -- Observed one confirmed rapid complete response with repeat dosing for ADG116 in combination with toripalimab in a tumor type where no anti-CTLA-4 therapy is currently approved. -- Presentation of data from this phase 1b/2 trial will take place at the Society for Immunotherapy of Cancer's 37th Annual Meeting (SITC 2022) in Boston, November 8-12, 2022. -- For competitive reasons, Adagene is currently not disclosing the dose or tumor types of these objective responses. -- Compelling safety demonstrated as a single agent and in combination with anti-PD-1: -- Completed monotherapy dose escalation of ADG116 in 30 patients up to 15 mg/kg administered every three weeks with repeat dosing, and continued to enroll patients in dose expansion at 10 mg/kg. -- Only one dose-limiting toxicity event reported at ESMO-IO 2021 for the 10 mg/kg dose. As of this release, no additional or late-onset dose-limiting toxicities reported with ADG116 monotherapy, including in patients who received more than four cycles. -- A safety review committee cleared advancement to dose expansion with 3 mg/kg of ADG116 for combination cohorts with toripalimab. -- Continued advancement of combinations with anti-PD-1 or anti-CD137: -- Completing dose escalation of ADG116 in combination with the anti-PD-1 antibody, pembrolizumab (ADG116-P001 / KEYNOTE-C97). Presentation of data from this phase 1b/2 trial will take place at SITC 2022. -- Evaluation ongoing of ADG116 in combination with the anti-CD137 therapy, ADG106, to optimize the dose and schedule for this novel, proprietary combination. Adagene is a global leader in exploring the synergistic clinical effects for the dual pathway targeting CTLA-4 and CD137 given the compelling preclinical rationale for this powerful combination. -- Paving the way for combination trials in China, advanced dose escalation to 10 mg/kg in phase 1 monotherapy trial (ADG116-1002). A significant untapped clinical and market opportunity exists for the proven combination of anti-CTLA-4 and anti-PD-1 therapies as the combination is only approved in one tumor type in China.

ADG126 (anti-CTLA-4 SAFEbody(R) targeting a unique epitope with precision masking)
-- Compelling clinical safety demonstrated at unprecedented dosing levels with repeat dosing: -- Completed monotherapy dose escalation of ADG126 in 19 patients up to 20 mg/kg administered every three weeks with repeat dosing, and continued to enroll patients in dose expansion at 10 mg/kg. -- ADG126 monotherapy was well tolerated with no dose-limiting toxicities or treatment-related serious adverse events observed following repeat dosing across all dose levels, as reported in an abstract at the 2022 American Society of Clinical Oncology annual meeting. -- Clinical evaluation with anti-PD-1 therapies is ongoing to establish the dose and schedule for phase 2 combination cohorts. In combination cohorts with toripalimab, the safety review committee has cleared the 6 mg/kg dose administered every three weeks, approved dose expansion at 6 mg/kg, and recommended further dose escalation to 10 mg/kg, the highest dose level ever reported for the combination of anti-CTLA-4 and anti-PD-1 therapies. -- Encouraging antitumor activity observed as monotherapy in cold tumors: -- In a cohort of heavily pre-treated patients, ADG126 monotherapy resulted in durable reductions in target lesions over 20% in two patients with cold tumors: -- One ovarian cancer patient who experienced significant, continued reduction of an established ovarian cancer biomarker, CA125, dropping 90% to within the normal range for full clinical benefit after receiving up to 18 cycles of treatment at 1 mg/kg, as of this release. -- One uveal melanoma patient who received prior immuno-oncology treatment, having progressed after the combination of nivolumab and ipilimumab. -- Updated interim results will be presented in a poster on September 12 at the European Society for Medical Oncology (ESMO) Congress 2022 in Paris, September 9 -- 13, 2022 -- Both monotherapy and combination trials continue to enroll patients with advanced, metastatic tumors in the US, China and APAC, evaluating optimized doses of ADG126 in targeted tumors. -- Pharmacokinetics show effectiveness of precision masking technology: -- In monotherapy evaluation, ADG126 plasma pharmacokinetics (PK) were approximately linear and activated ADG126 accumulated steadily during repeat dosing across different dose levels. -- This reflects prolonged exposures of activated ADG126 in the tumor microenvironment (TME), with cleaved ADG126 in plasma on average accumulating >2-fold during repeat dosing.

(MORE TO FOLLOW) Dow Jones Newswires

August 30, 2022 17:25 ET (21:25)

"PIPELINE & BUSINESS HIGHLIGHTS

ADG116 (anti-CTLA-4 NEObody(TM) targeting a unique epitope):



Observed one partial response with ADG116 monotherapy in a tumor type where no anti-CTLA-4 therapy is currently approved.





Completed monotherapy dose escalation of ADG116 in 30 patients up to 15 mg/kg administered every three weeks with repeat dosing, and continued to enroll patients in dose expansion at 10 mg/kg.





Completing dose escalation of ADG116 in combination with the anti-PD-1 antibody, pembrolizumab (ADG116-P001 / KEYNOTE-C97). Presentation of data from this phase 1b/2 trial will take place at SITC 2022.


ADG126 (anti-CTLA-4 SAFEbody(R) targeting a unique epitope with precision masking):




Completed monotherapy dose escalation of ADG126 in 19 patients up to 20 mg/kg administered every three weeks with repeat dosing, and continued to enroll patients in dose expansion at 10 mg/kg.





In a cohort of heavily pre-treated patients, ADG126 monotherapy resulted in durable reductions in target lesions over 20% in two patients with cold tumors:





One ovarian cancer patient who experienced significant, continued reduction of an established ovarian cancer biomarker, CA125, dropping 90% to within the normal range for full clinical benefit after receiving up to 18 cycles of treatment at 1 mg/kg, as of this release.





In monotherapy evaluation, ADG126 plasma pharmacokinetics (PK) were approximately linear and activated ADG126 accumulated steadily during repeat dosing across different dose levels.

ADG106 (agonistic anti-CD137 NEObody(TM)):




Results from the phase 1b/2 trial (ADG106-1008) in China evaluating ADG106 in combination with toripalimab, showed one observed partial response in a nasopharyngeal carcinoma (NPC) patient out of 20 patients enrolled. Currently, four patients remain on therapy.





Reflecting its strategic presence and collaborations in Singapore, Adagene continues to support the ongoing IITs in Singapore and explore the anti-CD137 opportunity with ADG106 in selected indications in a combination setting, including:





An ongoing phase 1b/2 clinical trial (ADG106-T6001) evaluating ADG106 in combination with the anti-PD-1 antibody, nivolumab, for patients with advanced non-small cell lung cancer (NSCLC) who have progressed after prior treatment. Dose escalation is complete and dose expansion is ongoing.


ADG206 (masked, IgG1 FC engineered anti-CD137 POWERbody(TM)):




Adagene submitted a Human Research Ethics Committee (HREC) regulatory filing in Australia to advance this anti-CD137 POWERbody(TM), ADG206, into a phase 1 clinical trial in patients with advanced metastatic solid tumors."


- 5:25p ET 8/30/2022 - Globe Newswire
Adagene Reports Financial Results for the Six Months Ended June 30, 2022 and Provides Corporate Updates

Still the best chart set up that I have currently in my research

“Additional data from ongoing ADG126 clinical program to be presented in second half of 2022, including safety in combination with anti-PD-1 therapies”

“Another exciting and surprising aspect of these interim findings is that we see early signals of efficacy in certain ‘cold’ tumors with SAFEbody ADG126, which further builds on prior clinical evidence with its parental antibody ADG116, targeting a unique epitope of CTLA-4 to enable not only a safer but potentially better therapy than the options we have available today.”

““Following these monotherapy dose escalation results, we look forward to releasing further data in coming months to confirm if the strong safety profile of ADG126 is preserved in combination with anti-PD-1 therapy, consistent with our preclinical observations,” said Peter Luo, Ph.D., Co-founder, Chief Executive Officer and Chairman of Adagene.”

6-K 05/26/2022

https://www.otcmarkets.com/filing/html?id=15852709&guid=pD9-kWAqNv9JqBh

Sanofi news today hopefully, 6 months ago:

“8:22a ET 3/2/2022 - MarketWatch
Sanofi to pay up to $2.5 billion in deal with Adagene

Shares of Adagene Inc. (ADAG) jumped 11.2% in premarket trading on Wednesday after it announced a licensing and commercialization deal with Sanofi (SAN.FR) that is worth up to $2.5 billion. U.S.-listed shares of Sanofi were down 1.5%. Adagene will develop masked versions of up to four of Sanofi's antibodies in development. Per the terms of the deal, Sanofi will pay Adadene $17.5 million now; however, the milestone payments are worth up to $2.5 billion, and the company is eligible for royalties based on sales of the therapies if they are commercialized.”

This can be a big moment for the company, the chart is ready and primed

ADAG’s charts are positioned better than any stock for a spike higher on Monday, this can be one of the bright spots in this market, let’s see if they take advantage of the opportunity

A close at 1.41 would be absolute chart perfection for Monday

This stock chart is so overdue for a spike it is incredible, just need a spark

ADAG and the Night King, Game of Thrones August 21, One year Williams indicator

“6:15a ET 3/2/2022 - Dow Jones
Adagene in Antibody Licensing Agreement With Sanofi

By Chris Wack

Adagene Inc. said it has entered into a collaboration and exclusive license agreement with Sanofi to generate masked monoclonal and bispecific antibodies for development and commercialization by Sanofi.

Under the agreement, Adagene will be responsible for early stage research activities to develop masked versions of Sanofi candidate antibodies, using Adagene's SAFEbody technology.

Sanofi will be solely responsible for later stage research and all clinical, product development and commercialization activities.

Adagene said Sanofi will make an upfront payment of $17.5 million and will have the ability to advance two initial Sanofi antibody candidates in the collaboration, followed by an option for two additional candidates. Adagene will be eligible to receive total potential development, regulatory and commercial milestone payments of up to $2.5 billion for advancement of the candidates, which will be exclusively developed and commercialized by Sanofi. Adagene is eligible also to receive tiered royalties on global net sales of approved collaboration products.

SAFEbody technology was designed by Adagene to address safety and tolerability challenges associated with many antibody therapeutics by using precision masking technology to shield the binding domain of the biologic therapy.

Write to Chris Wack at chris.wack@wsj.com

(END) Dow Jones Newswires

March 02, 2022 06:15 ET (11:15 GMT)
Copyright (c) 2022 Dow Jones & Company, Inc.”

2.5 billion dollar deal was made in March…

“8:22a ET 3/2/2022 - MarketWatch
Sanofi to pay up to $2.5 billion in deal with Adagene

Shares of Adagene Inc. (ADAG) jumped 11.2% in premarket trading on Wednesday after it announced a licensing and commercialization deal with Sanofi (SAN.FR) that is worth up to $2.5 billion. U.S.-listed shares of Sanofi were down 1.5%. Adagene will develop masked versions of up to four of Sanofi's antibodies in development. Per the terms of the deal, Sanofi will pay Adadene $17.5 million now; however, the milestone payments are worth up to $2.5 billion, and the company is eligible for royalties based on sales of the therapies if they are commercialized. Adagene's stock has tumbled 77.6% over the past year, while the S&P 500 is up 10.3%.

-Jaimy Lee

(END) Dow Jones Newswires

March 02, 2022 08:22 ET (13:22 GMT)
Copyright (c) 2022 Dow Jones & Company, Inc.”

4.5 months since that deal.

Today the Uvalde video will be released publicly showing the police dodging their responsibilities, A DAG with a soft “G” sounds like “A dodge”, while “A” in Spanish means “To”, therefore “To dodge”, secondly a BHAT (Bat) is a weapon, as is A DAG(ger), BHAT went up 800%.

People sleeping on ADAG but starting to figure out

ADAG has been under the MACD since last September can this stock wake up please, buyback program and 2.5 billion in revenue and products they offer as well, needs to get above water with a big roar.

2.5 Billion dollars incoming to ADAG:

“8:22a ET 3/2/2022 - MarketWatch
Sanofi to pay up to $2.5 billion in deal with Adagene

Shares of Adagene Inc. (ADAG) jumped 11.2% in premarket trading on Wednesday after it announced a licensing and commercialization deal with Sanofi (SAN.FR) that is worth up to $2.5 billion. U.S.-listed shares of Sanofi were down 1.5%. Adagene will develop masked versions of up to four of Sanofi's antibodies in development. Per the terms of the deal, Sanofi will pay Adadene $17.5 million now; however, the milestone payments are worth up to $2.5 billion, and the company is eligible for royalties based on sales of the therapies if they are commercialized. Adagene's stock has tumbled 77.6% over the past year, while the S&P 500 is up 10.3%.

-Jaimy Lee

(END) Dow Jones Newswires

March 02, 2022 08:22 ET (13:22 GMT)
Copyright (c) 2022 Dow Jones & Company, Inc.”

Bid/ask spread is wide and ask is as thin as it gets, not many shares left, if it goes on a run it will run hard

ADAG-ger

2.5 billion in future revenue:

“8:22a ET 3/2/2022 - MarketWatch
Sanofi to pay up to $2.5 billion in deal with Adagene

Shares of Adagene Inc. (ADAG) jumped 11.2% in premarket trading on Wednesday after it announced a licensing and commercialization deal with Sanofi (SAN.FR) that is worth up to $2.5 billion. U.S.-listed shares of Sanofi were down 1.5%. Adagene will develop masked versions of up to four of Sanofi's antibodies in development. Per the terms of the deal, Sanofi will pay Adadene $17.5 million now; however, the milestone payments are worth up to $2.5 billion, and the company is eligible for royalties based on sales of the therapies if they are commercialized. Adagene's stock has tumbled 77.6% over the past year, while the S&P 500 is up 10.3%.

-Jaimy Lee

(END) Dow Jones Newswires”

“4:05p ET 6/29/2022 - Globe Newswire
Adagene Announces Authorization of Share Repurchase Program up to US$10 Million

EQNX::TICKER_START (NasdaqGM:ADAG), EQNX::TICKER_END Adagene Inc. ("Adagene") (Nasdaq: ADAG), a company transforming the discovery and development of novel antibody-based therapies, today announced that its board of directors has authorized a share repurchase program under which, Adagene may repurchase up to US$10 million of its ordinary shares in the form of American depositary shares, subject to the relevant rules under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the Company's insider trading policy (such repurchase program, the "2022 Share Repurchase Program").

The Company's share repurchases, if any, under the 2022 Share Repurchase Program may be made from time to time on the open market at prevailing market prices, in open-market transactions, privately negotiated transactions or block trades, and/or through other legally permissible means, depending on market conditions and in accordance with the applicable rules and regulations. The timing and conditions of the share repurchases will be subject to various factors including the requirements under Rule 10b-18 and Rule 10b5-1 of the Exchange Act. The Company's board of directors will review the 2022 Share Repurchase Program periodically and may authorize adjustments to its terms and size or suspend or discontinue the program. The Company expects to utilize its existing funds to fund repurchases made under this program.

The Company has disclosed certain details of the repurchases made in accordance with the prior share repurchase program in its annual report for the year ended December 31, 2021 filed with the SEC. See Item 16.E. Purchases of Equity Securities by the Issuer and Affiliated Purchasers on page 212.

The 2022 Share Repurchase Program will be effective upon and from the date on which a formal stock repurchase plan engagement agreement is signed with a qualified broker-dealer(s), and terminates over a twelve-month period depending upon market and economic conditions, and other factors including price, legal and regulatory requirements and capital availability. The 2022 Share Repurchase Program does not obligate Adagene to acquire any particular number of American depositary shares, and the 2022 Share Repurchase Program may be modified or suspended at any time at the management's discretion.”

Buying back a good percentage of the float, chart is ready, be ready