Mayo Clinic Zooms in on Nanobacteria
2007年2月2日 - 1:15AM
ビジネスワイヤ(英語)
Nanobac Pharmaceuticals, Inc. (OTCBB:NNBP) announces scientists at
Mayo, working under a collaborative agreement with Nanobac
Pharmaceuticals Inc., have published an article in the Journal of
Investigative Medicine regarding successfully isolating
nanoparticles from human kidney stones in cell cultures. The Mayo
scientists also isolated proteins, RNA and DNA that appear to be
associated with the nanoparticles or CNPs. Entitled "Mayo Clinic
Zooms In On Nanobacteria," the paper describes why the Mayo
researchers say the findings could lead to solving the mystery of
whether nanoparticles are viable living forms that can lead to
disease - in this case, kidney stones. "We are looking at how
kidney stones start as very small calcifications inside the kidney
and then eventually grow into stones," said Mayo Clinic's John
Lieske. "In the laboratory, we have isolated nanoparticles from
kidney tissue and kidney stones, and have successfully propagated
them in culture. This does not clearly confirm the role of
nanoparticles in the formation of kidney stones, but it offers
insight not otherwise known." Intriguingly, the study cites
evidence that the calcification process is not driven solely by
physical chemistry, but instead is influenced by specific proteins
and cellular responses. "There are at least two novel hypotheses
here in terms of how stones might actually form. One: an infectious
agent. If that was the case, that would point us in the direction
of using different kinds of treatments specific to an infectious
agent. Two: the idea that cells drive calcification. That would
suggest other alternative therapies," added co-researcher Virginia
Miller. Dr. Maniscalco, co-chair of Nanobac, stated, �We believed
that CNPs play a major role in one of the most pervasive medical
conditions in existence: calcification of arteries and organs. This
study conducted by one of the lead medical and research facilities
in the United States, lends credence to our beliefs.� About Nanobac
Pharmaceuticals: Nanobac Pharmaceuticals, Inc. is dedicated to the
discovery and development of products and services to improve human
health through the detection and treatment of calcifying
nanoparticles (CNPs), formerly known as nanobacteria. The company's
pioneering research is establishing the pathogenic role of CNPs in
soft tissue calcification, particularly in coronary artery,
prostate and vascular disease. Nanobac's drug discovery and
development is focused on new and existing compounds that
effectively inhibit, destroy or neutralize CNPs. Nanobac
manufactures In Vitro Diagnostic (IVD) kits and reagents for
detecting calcifying nanoparticles. IVD products include a line of
assays, proprietary antibodies and reagents for uniquely
recognizing CNPs. Nanobac's BioAnalytical Services works with
biopharmaceutical partners to develop and apply methods for
avoiding, detecting, and inactivating or eliminating CNPs from raw
materials. Nanobac Pharmaceuticals, Inc. is headquartered in Tampa,
Florida. For more information, visit our website at:
http://www.nanobac.com. Investors are cautioned that certain
statements in this document, some statements in periodic press
releases and some oral statements of Nanobac Pharmaceuticals, Inc.
officials are "Forward-Looking Statements" within the meaning of
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Pharmaceuticals, Inc. actions, which may be provided by management,
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has no specific intention to update these statements.
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