IMS Ims Health Holdings, Inc.

EXPLANATORY NOTE

IMS Health Holdings, Inc., a Delaware corporation (the “ Registrant ”), is filing this post-effective amendment to deregister certain securities originally registered pursuant to the Registration Statement on Form S-8 filed on April 9, 2014 (file no. 333-176155) with respect to shares of the Registrant’s Common Stock, par value $0.01 (the “ Common Stock ”). These shares were registered for offer or sale pursuant to (i) Healthcare Technology Holdings, Inc. 2010 Equity Incentive Plan, (ii) IMS Health Holdings, Inc. 2014 Incentive and Stock Award Plan and (iii) IMS Health Incorporated Defined Contribution Executive Retirement Plan (collectively, the “ Plans ”). A total of 49,370,150 shares were registered for issuance under the Plans.

On May 3, 2016, Quintiles Transnational Holdings Inc., a North Carolina corporation (“ Quintiles ”), and the Registrant entered into an Agreement and Plan of Merger (the “ Merger Agreement ”). Pursuant to the Merger Agreement, the Registrant will merge with and into Quintiles, with Quintiles continuing as the surviving corporation (the “ Surviving Corporation ”), and the separate corporate existence of the Registrant will cease (the “ Merger ”). Immediately prior to the completion of the Merger, Quintiles will convert to a Delaware corporation. Pursuant to the Merger Agreement, Quintiles, as the Surviving Corporation, will assume the obligations of the Registrant under the Plans. Consequently, no future awards will be made under the Plans. As a result of the transactions contemplated by the Merger, the Registrant has terminated all offerings of the Registrant’s Common Stock pursuant to the Registration Statement and hereby removes and withdraws from registration all securities registered pursuant to the Registration Statement that remain unsold as of the date hereof.