Explanation of Responses:
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1)
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The number of shares disposed of includes 2,379 shares acquired under the Issuer's 2008 Employee Stock Purchase Plan.
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2)
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Pursuant to the Agreement and Plan of Merger, dated September 5, 2013, between the Issuer, Otsuka Pharmaceutical Co., Ltd., and Autumn Acquisition Corporation (the "Merger Agreement"), each share of Common Stock was exchanged for $8.50 in cash.
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3)
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The option provided for vesting as to 1/48th of the shares on April 4, 2005 and on each one month anniversary thereafter.
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4)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $90,250.00, which represents the difference between $8.50 and the exercise price of the option per share.
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5)
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The option provided for vesting as to 1/48th of the shares on April 9, 2006 and on each one month anniversary thereafter.
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6)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $204,000.00, which represents the difference between $8.50 and the exercise price of the option per share.
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7)
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The option provided for vesting as to 1/48th of the shares on April 15, 2007 and on each one month anniversary thereafter.
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8)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $135,945.00, which represents the difference between $8.50 and the exercise price of the option per share.
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9)
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The option provided for vesting as to 1/48th of the shares on April 13, 2008 and on each one month anniversary thereafter.
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10)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $590,400.00, which represents the difference between $8.50 and the exercise price of the option per share.
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11)
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The option, originally for 80,000 shares and of which 12,500 shares have been exercised, provided for vesting as to 1/48th of the shares on April 12, 2009 and on each one month anniversary thereafter.
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12)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $462,375.00, which represents the difference between $8.50 and the exercise price of the option per share.
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13)
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The option originally provided for vesting as to 1/48th of the shares on April 11, 2010 and on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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14)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $579,700.00, which represents the difference between $8.50 and the exercise price of the option per share.
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15)
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The option originally provided for vesting as to 1/48th of the shares on April 24, 2011 and on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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16)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $858,000.00 which represents the difference between $8.50 and the exercise price of the option per share.
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17)
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The option originally provided for vesting as to 1/48th of the shares on April 7, 2012 and on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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18)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,057,600.00, which represents the difference between $8.50 and the exercise price of the option per share.
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19)
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The option originally provided for vesting as to 1/48th of the shares on January 6, 2013 and on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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20)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $926,400.00, which represents the difference between $8.50 and the exercise price of the option per share.
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