TIDMABH

RNS Number : 5824E

Angel Biotechnology Holdings Plc

01 June 2012

1 June 2012

Angel Biotechnology Holdings plc

("Angel" or "the Company")

Angel announces final results for period ended 31 March 2012

Angel Biotechnology Holdings plc, (AIM:ABH), the biopharmaceutical contract manufacturer, is pleased to announce its audited final results for the fifteen month period ended 31 March 2012.

Financial highlights for the period include:

   --     Revenue of GBP3.456 million (2010: GBP2.945 million*). 

-- Gross profit of GBP1.207 million (2010: GBP1.907 million*). The reduction in gross profit margin is partly as a result of the expenditure required at Cramlington to ensure the facility is fully prepared for its initial MHRA inspection.

-- Other costs relating to Cramlington have been included in the net operating expenses which have increased by GBP0.828 million.

   --     Loss before taxation of GBP1.299 million. 

-- Seven contracts and contract extensions signed totalling GBP5.3 million (2010: GBP5.3 million*).

-- Angel has dedicated its Pentlands facility, which is operating at capacity, to servicing existing clients. As a result 100% of reported revenue related to continuing and repeat clients.

-- Total assets increased by over GBP1.1 million to GBP2.7 million whilst total liabilities decreased by GBP0.6 million to GBP0.9 million resulting in a positive net asset value the period end of GBP1.8 million.

-- The current ratio has improved significantly over the period and was 2.25 at the end of the period compared to 0.77 at the end of 2010.

-- Effective financial control and cash management have seen our debtor days stabilise at an average of 36 days (2010: 18 days) and creditor days reduce to 36 days (2010: 58 days).

   --     Successful placement of ordinary shares raising GBP3.087 million before expenses. 

*Previous financial reporting period was 12 months

Business Development and Operational Highlights

-- Four new contracts were signed comprising a mixture of cell therapy programmes, therapeutic antibodies with seven contracts also signed for additional work on previously signed contracts.

-- GMP manufacture of ReNeuron Group plc's clinical material for the PISCES trial at Glasgow's Southern General Hospital continued, with the number of patients treated within the period reaching five.

-- Conference attendance by Angel was again significant over the period, with nine conferences in total attended across USA and Europe.

-- Continued invitations to make presentations at conferences demonstrate the Company's standing in the sector enabling Angel to increase its profile, particularly in relation to stem cell manufacturing.

-- Business development activities have and will continue to evolve and move Angel into new territories and markets both for its core business and its Angel Biomedical Ltd subsidiary.

-- Angel completed a range of both development and biomanufacturing projects during the period. This includes a bacteriophage project for the treatment of MRSA and a cell culture development project for Pathfinder Cell Therapy Inc.

-- The Company has committed significant resource to drive forward the five current projects which are on-going for OOO "NPF" Materia Medica in addition to the three further contracts recently signed.

Post Balance Sheet Events

The Directors believe Angel has had a very successful start to the new financial year. In April the Company signed a contract with TransGenRx Inc. for the development of a process to manufacture recombinant interferon with a value of in excess of GBP800k. This will be carried out at Cramlington and would not have been won without this facility. It is clear from discussions with clients with programmes suitable for the Cramlington facility that they will not commit to final discussions before granting of an MHRA licence. These are high value programmes and this is not an unreasonable position for sponsor companies to take. The Medicines and Healthcare products Regulatory Agency (MHRA) licensing inspection for Cramlington is planned for mid-June 2012.

Angel Biomedical Ltd (ABL)

Angel identified an opportunity to acquire the assets of a manufacturing business in February 2012. Dr Stewart White had knowledge of this business and the relevant sectors, which catalysed an early decision to open negotiations. A provisional business plan showed the potential for a significant and profitable additional business within the Angel group. Preliminary discussions indicated that there might be continued interest from the customers and the Board took the decision to proceed with the asset purchase.

It was for this reason that the Company decided to take additional cash in the second phase of the placement, to finance this activity without impacting on the on-going investment within Angel. This second phase raised a total of GBP1 million before expenses including the funding for ABL.

Dr Paul Harper, Executive Chairman said:

"The Company's resources have been at full stretch throughout this period. The task of re-commissioning Cramlington, opening business development discussions with new clients who would use the GMP manufacturing capability of that facility and latterly integrating a new business whilst maintaining full services to all our current clients has presented a considerable challenge. Staff at all levels within the business have shown the highest level of commitment and professionalism to deliver the required outcomes. The support of our shareholder base in ensuring that we have had the funds to complete these tasks has been important as has the shift towards investment from new institutional investors. We will now concentrate on consolidating our business and delivering shareholder value."

For further information:

Angel Biotechnology Holdings plc

Lorna Peers, Finance Director +44 (0) 131 445 6077

Stewart White, Acting CEO/Commercial Director www.angelbio.com

Grant Thornton, Corporate Finance

Colin Aaronson / Melanie Frean +44 (0) 20 7383 5100

Hybridan LLP (Broker)

Claire Noyce, Deepak Reddy +44 (0) 20 7947 4350

Media enquiries:

The Communications Portfolio Ltd

Ariane Comstive / Caolan Mahon +44 (0) 20 7536 2028 / 2029

ariane.comstive@communications-portfolio.co.uk

Notes to Editors:

Angel Biotechnology Holdings plc is a full service contract bio-manufacturing partner to biotechnology and pharmaceutical companies worldwide. Angel specialises in advanced biologics including biopharmaceutical proteins and cell therapies, such as cellular vaccines and stem cells. At present, Angel's products are principally used in pre-clinical studies and clinical trials with a view to becoming the contract manufacturer of choice on a continuing basis.

Drug development companies outsource their biopharmaceutical manufacturing requirements to Angel to reduce their own capital requirements and enable them to develop products more rapidly. In addition, Angel provides complete regulatory services and documentation to its customers while its manufacturing processes adhere to the most stringent regulatory requirements. Products are produced to current Good Manufacturing Practice (cGMP) standards as required by the US Food and Drug Administration (FDA), and in facilities that are certified to European standards by the Medicines and Healthcare products Regulatory Agency (MHRA).

Its customers range from early-stage biotechnology companies including ReNeuron plc and US-based Pathfinder Cell Therapy Inc, to established pharmaceutical companies such as Russian-based OOO "NPF" Materia Medica Holdings.

Angel has three facilities: Pentlands Science Park near Edinburgh where it employs 38 people, a site in Cramlington, near Newcastle-upon-Tyne, which is expected to employ up to 10 people by the end of 2012 and Angel Biomedical Ltd facility in Glasgow.

More information is available at www.angelbio.com .

CHAIRMAN AND ACTING CHIEF EXECUTIVE OFFICER'S REPORT

The Company has concentrated its efforts this period on delivering the goals and targets set out in the last Annual Report.

-- The key deliverable was to complete the re-commissioning of the Cramlington facility which has progressed with only minor delays where we chose to implement upgrades to facilitate extending our MHRA licences to include this facility, avoiding disruption later this year.

-- We maximised the revenue generating potential of the Pentlands facility through careful planning and management of the work flows and mix of projects to ensure maximum efficiency.

-- Business development activities were boosted to ensure that both existing and new clients were aware of the new capacity and resource that the Cramlington facility adds to our existing offering.

-- The agreement for the proposed joint venture with Materia Medica Holdings (MMH) which was first announced on 17 October 2011 has made significant progress, and we have identified space in Cramlington for the new dedicated GMP area with the aim to design, build and commission by Q1 2013.

-- We took the opportunity to re-structure our senior team to focus on business generation, improved management of our resources and to build greater quality and depth in our technical team.

During the period, the Company was able to secure sufficient contracts to utilise our Pentlands facility. However, without further capacity at Pentlands it proved a challenge to sign significant new business. Future growth will be related to the provision of new capacity at Cramlington providing confidence to both existing and potential customers that Angel can provide for the larger capacities required by later stage clinical trials. For the period ended 31 March 2012, we therefore forecast that revenues in the period would be similar to that for 2010 (on an annualised basis) whilst costs would increase to reflect the investment in the Cramlington facility including the purchase of new equipment and hiring of essential staff in preparation for licensing. Whilst we have generated interest from new clients in placing contracts, as exemplified by the recent announcement concerning TransGenRx, most are waiting for confirmation that a licence has been granted before finalising discussions.

Corporate Achievements and Milestones in 2011/12

Angel completed a fundraising in January 2011 raising GBP1.962m in an oversubscribed placement. The funds were raised to provide more working capital to support increased business from Materia Medica (MMH) and to fund the re-commissioning of the new Cramlington facility.

The lease for Cramlington was signed in March 2011 and WHP Engineering were contracted to begin the process of reversing the mothballing of the facility. The new facility will increase our GMP manufacturing capacity five-fold and allow us to bid for larger and potentially more profitable contracts that would be too large to carry out at Pentlands.

In 2011, the Company changed its reporting date from 31 December to 31 March. This change has resulted in a 15 month period ending on 31 March 2012 and the Company thereafter will return to a 12 month reporting schedule. In March 2011, Lorna Peers was appointed Finance Director and joined the Board of the Company.

Despite the fact that we could not increase our manufacturing capacity in the period, we signed contract extensions with Pathfinder, MMH and ReNeuron. In addition, we proposed a joint venture undertaking with MMH in which part of the Cramlington facility would be developed as an extension to the existing GMP area, the work to be funded by MMH, and the dedicated facility to be operated by Angel. This would allow Angel to sign up new MMH business without interfering with our ability to bring in contracts from new clients. As a consequence, three new MMH contracts were signed with a value in excess of GBP4.5m, for completion over a 22 month period. These projects will be initiated in the Angel manufacturing space at Cramlington, before the new MMH extension is ready and before an MHRA license is granted as these early phases can be carried out in a non-GMP environment.

The joint venture will change the contract structure such that Angel receives regular revenue from each programme rather than payment on attainment of milestones. The design of the MMH facility extension has now been agreed and legal agreements are at an advanced stage.

Towards the end of 2011 the Board decided to take the opportunity to raise additional capital and a placement was undertaken in two phases.

The funds were required to:

-- Ensure that the work at Cramlington remained on schedule and that enhancements to the GMP facility could be implemented to avoid disruption in activities later this year.

-- Purchase essential new equipment in the absence of cost effective equipment leasing facilities.

   --     Invest in the recruitment needed to manage a much larger manufacturing resource. 

-- Invest in the business development activities required to build the pipeline for Cramlington.

-- Invest in establishing the MMH joint venture facility. Whilst MMH fund the design and build, Angel will have some costs in licensing and QA/QC activities.

-- Fund an acquisition opportunity which became available between the two phases of the placement which led to the establishment of a new subsidiary, Angel Biomedical Ltd.

The additional capital raised in the period has been used to invest in the business, in particular, to ensure that the Cramlington facility is completed on time. We have taken the opportunity to make significant upgrades to the facility, these take account of changes in the licencing requirements since the GMP facility was first designed, improve the operation of the facility to minimise the operational resource required and will also limit potential lost time due to unscheduled shut downs. MMH projects have begun in the development labs at Cramlington while the joint venture is being finalised. MMH have asked that Angel design a more sophisticated facility than first envisaged but both parties have agreed the footprint which leaves the existing capacity for Angel programmes as originally planned. A design has been agreed and build should be complete by Q1 2013. The design, build and fit-out costs will be paid by MMH. Angel has the responsibility for providing staff, ensuring that the facility is licenced and for providing the infrastructure and technical support for projects to be undertaken at the facility. In the meantime, MMH programmes will continue in the main part of the facility.

Dr Stewart White joined the Board of the Company as Commercial Director in December 2011. He was recruited as a dedicated and experienced business development expert with the objective of boosting and focusing our existing team to meet the challenge of filling Cramlington with new business. The Board believed that Stewart had the experience and ability to take on a more senior role as the Company grows.

Following Gordon Sherriff's decision to leave the Company, the Board decided to restructure the senior team to maintain our customer service and quality standards. Part of the restructuring process included the appointment of Dr Stewart White as Acting CEO and the formation of an Executive Committee of the Board involving executive directors and senior management.

Re-commissioning Cramlington, whilst maintaining the effort required at Pentlands to deliver the maximum revenue possible and to take over a new manufacturing business as seamlessly as possible could only be achieved with the support and dedication of experienced and industrious staff, at all levels within the business. The Board of Angel thank the team for their hard work and commitment.

The impact of the current global economic uncertainty directly affects R&D spend and the availability of investment to fund new product development. Despite these challenges, Angel has been able to rely upon its reputation for quality and customer service coupled by the breadth and depth of our technical resource to attract new business. Fortunately we have a good level of repeat business which has provided considerable support in these difficult times.

Business Development

   --     The total value of contracts signed in the period ending 31 March 2012 was GBP5.3m. 

-- Four new contracts were signed comprising a mixture of cell therapy programmes, therapeutic antibodies with seven contracts also signed for additional work on previously signed contracts.

-- Conference attendance by Angel delegates was again significant over the period, with nine conferences in total attended across USA and Europe. The continued invitations to make presentations demonstrate the company's standing in the sector enabling Angel to increase its profile, particularly in relation to stem cell manufacturing.

-- As part of the commercial review towards the end of the period, the team carried out a pricing review via benchmarking. This continues our shared risk approach during development stages of projects, moving revenue recognition and cash generation away from purely milestone related activities.

   --     Angel continued its relationship with BPTC in the USA who act as a commission-based agent. 

-- Business development activities have and will continue to evolve and Angel into new territories and markets both for its core business and its ABL subsidiary.

-- There will be an increased focus on establishing meaningful presence in our growth territories.

Operations

-- Our development and GMP operations yielded revenues of GBP3.456 million in the period resulting in a gross profit of GBP1.207 million (35%).

-- The Company is committed to continual improvement in our operations and invested in our Pentlands cleanroom facility, in preparation for the MHRA inspection mid-year 2012.

-- GMP manufacture of ReNeuron's clinical material for the PISCES trial at Glasgow's Southern General Hospital continued, with the number of patients treated in the period reaching five.

-- The Company has committed significant resource to drive forward the five current projects which are on-going for Materia Medica in addition to the three further contracts recently signed.

-- Angel completed a range of both development and biomanufacturing projects during the period. This includes a bacteriophage project for the treatment of MRSA and a cell culture development project for Pathfinder.

Having expanded over an additional site, operational activities within the group will continue to be managed carefully and will allow the Company to demonstrate its commitment to providing the necessary capacity, synchronising any additional expansion with sustainable revenue generation. The Company has already demonstrated its ability in this regard by during the period, re-commissioning Cramlington with only an additional headcount of five. The operational capabilities of Angel are now fit for purpose and can provide the necessary expertise at the scale our customers demand.

Finance

-- Revenue for the fifteen month period to 31 March 2012 of GBP3.456 million (12 months to December 2010: GBP2.945 million).

-- Gross profit for the fifteen month period to 31 March 2012 of GBP1.207 million (12 months to December 2010: GBP1.907 million). The reduction in gross profit margin is partly as a result of the expenditure required at Cramlington to ensure the facility is fully prepared for its initial MHRA inspection.

-- Other costs relating to Cramlington have been included in the net operating expenses which have increased by GBP0.828 million.

-- Seven contracts and contract extensions signed totalling GBP5.3 million (2010: GBP5.3 million).

   --     Successful placement of ordinary shares raising GBP3.087 million before expenses. 

-- 58% of the revenue for the period was generated by one customer, Materia Medica. This percentage has remained static over both periods. Our aim, with Cramlington coming on-line, is to see this percentage reduced during the year ending March 2013.

-- Angel has dedicated its Pentlands facility, which is operating at capacity, to servicing existing clients. As a result 100% of reported revenue related to continuing and repeat clients and a total of seven contracts were completed during the period.

-- Total assets increased by over GBP1.1 million whilst total liabilities decreased by GBP0.6 million to GBP0.9 million resulting in a positive net asset value at the period end of GBP1.8 million.

-- The current ratio has improved significantly over the period and was 2.25 at the period end compared to 0.77 at the end of 2010.

   --     The convertible loan to EphaG was repaid in full as anticipated by June 2011. 

-- Effective financial control and cash management have seen our receivables days stabilise at an average of 36 days (2010: 18 days) and payable days reduce to 36 days (2010: 58 days).

Post Balance Sheet Events

The directors believe Angel has had a very successful start to the new financial year. In April, we signed a contract with TransGenRx Inc. for the development of a process to manufacture recombinant interferon with a value of in excess of GBP800k. This will be carried out in Cramlington and would not have been won without this facility. It is clear from discussions with clients with programmes suitable for the Cramlington facility that they will not commit to final discussions before the granting of a licence. These are high value programmes and this is not an unreasonable position for sponsor companies to take. The Medicines and Healthcare products Regulatory Agency (MHRA) licensing inspection for Cramlington is planned for mid-June 2012.

Angel Biomedical Ltd (ABL)

Angel identified an opportunity to acquire the assets of a manufacturing business in February 2012. Dr White had knowledge of this business and the relevant sectors, which catalysed an early decision to open negotiations. A provisional business plan showed the potential for a significant and profitable additional business within the Angel group. Preliminary discussions indicated that there might be continued interest from the customers and the Board took the decision to proceed with the asset purchase. It was for this reason that the Company decided to take additional cash in the second phase of the placement, to finance this activity without impact on the on-going investment within Angel.

ABL comprises 6,500 sq ft of clean room and laboratory space in a state of the art building on the outskirts of Glasgow. The facility and processes have been previously accredited to ISO 13485 and ISO 22442 to support the manufacture of collagen-based products. All necessary assets have been transferred to ABL to allow continuation of manufacturing, including a small number of staff. It is, for practical purposes, a going concern.

Collagen has been used in medical applications for decades. However, the provenance of material is critical with material procured from countries which can claim to have no incidence of bovine spongiform encephalitis. Of great importance to ABL is the fact that the material sourcing, process, facility and a medical device product have previously been through FDA approval. ABL manufactures collagen raw materials and can convert this material into a matrix which can be fashioned and formulated to suit a very wide range of applications in the medical devices, in-vitro diagnostics and regenerative medicine industries.

ABL integrates well with the Angel core business in stem cells and cell therapy products, in that Angel group can now offer an integrated service by providing a custom collagen matrix, processed stem cells and assemble a finished product to GMP standards. Indeed, Angel has carried out similar work previously for Azellon who produce an autologous meniscal bandage.

The formation of ABL extends Angel's distinctive competencies by providing a turn-key solution for the development and manufacture of tissue engineering products by providing not only the biological component, but also the mechanism of delivery.

In addition to these advanced products, ABL will also develop a wider customer base providing collagen products which will allow more rapid revenue generation due to reduced regulatory requirements. For example, collagen materials are used in-vitro diagnostics, R&D and cosmetics applications.

Support services for ABL will be provided by Angel and the corporate overhead will be leveraged over a larger and more diverse revenue generating operation.

Since acquiring these assets ABL has secured and announced a supply agreement with Cardium Therapeutics with a value in excess of GBP400k for the initial twelve month period. The agreement covers the manufacture of formulated collagen for Cardium's Excellagen product, which has recently been cleared for marketing by the US Food and Drug Administration (FDA). Excellagen is a professional use high molecular weight fibrillar Type 1 collagen topical gel (2.6%) specifically engineered as an adjunct to debridement for the management of diabetic foot ulcers and other dermal wounds.

In addition to this, ABL will assist Cardium in gaining a CE Mark for Excellagen for marketing and sale in the European Union and in other countries recognising CE Mark approval. ABL will also support Cardium in establishing its own Device Master File with the FDA's Center for Devices and Radiological Health.

Outlook

The business has gone through an intense period of change as we have built up our manufacturing capacity whilst adding new products and services in particular, establishing and integrating our new business, ABL. Our staff have risen to the challenge and have managed to maintain the target level of revenue generating activities whilst managing the re-commissioning of Cramlington. We expect the next period to be one of consolidation with emphasis on signing new business for both ABH and ABL and driving the synergies possible through combining the resources of these two businesses.

ABL allows us to tap into a wholly new market for Angel, accessing new customers and opportunities that would not formally have been available. Since we expect this new business to be self-sustaining the overall impact on the Group should be positive.

The business environment remains relatively difficult with development spend under tight control in most businesses and the available funding to support such activities difficult to come by. Re-structuring, down-sizing and setting changed priorities in the healthcare sector continues and shows

no signs of slowing and more consolidation is expected. Broadening our business offering will allow the business to tap into more opportunities and this should help mitigate some of these factors.

The Directors believe that the strategy pursued to build capacity and functionality remains the right one and positions the business to take advantage of and to generate new opportunities.

Dr Paul Harper

Chairman, Angel Biotechnology Holdings Plc

Dr Stewart White

Acting Chief Executive Officer, Angel Biotechnology Holdings Plc

31 May 2012

Statement of comprehensive income for the PERIOD ended 31 MARCH 2012

 
                                                                      Period ended         Year ended 
                                                              Notes      31-Mar-12          31-Dec-10 
                                                                               GBP                GBP 
 
 Revenue                                                          2      3,455,936          2,945,201 
 Cost of sales                                                         (2,249,141)        (1,038,447) 
 
 Gross profit                                                            1,206,795          1,906,754 
                                                                     -------------      ------------- 
 
  Net operating expenses                                               (2,473,136)        (1,645,006) 
 
 Operating (loss)/profit                                          3    (1,266,341)            261,748 
                                                                     -------------      ------------- 
 
  Finance income                                                  4          2,437              1,239 
 Finance costs                                                    5       (34,856)           (69,696) 
 
 (Loss)/Profit before taxation                                         (1,298,760)            193,291 
                                                                     -------------      ------------- 
 
 UK corporation tax                                               7              -                  - 
 
 
 (Loss)/Profit for the year and total comprehensive income 
  attributable to owners of the Company                                (1,298,760)            193,291 
                                                                     -------------      ------------- 
 
 (Loss)/Profit per share (pence) 
 Basic                                                            8        (0.047)   p           0.01   p 
 
 Diluted                                                          8        (0.047)   p           0.01   p 
 
 
 
 BALANCE SHEET AS AT 31 MARCH 2012 
 
 
                                                 Notes     31-Mar-12     31-Dec-10 
                                                                 GBP           GBP 
 
 Non-current assets 
 Intangible assets                                  10         4,360         6,873 
 Property, plant and equipment                      11       988,548       416,155 
 
                                                             992,908       423,028 
 
 Current assets 
 Trade and other receivables                        13     1,126,634       532,190 
 Cash and cash equivalents                                   580,255       613,339 
                                                           1,706,889     1,145,529 
 
 Total assets                                              2,699,797     1,568,557 
                                                        ------------  ------------ 
 
 Current liabilities 
 Trade and other payables                           13     (382,957)     (377,938) 
 Finance leases                                     12      (50,349)             - 
 Loans                                              14      (14,037)     (358,108) 
 Deferred income                                           (312,432)     (757,636) 
                                                        ------------  ------------ 
                                                           (759,775)   (1,493,682) 
 Non-current liabilities 
 Finance leases                                     12     (134,706)             - 
 
 Total liabilities                                         (894,481)   (1,493,682) 
                                                        ------------  ------------ 
 
 Net assets                                                1,805,316        74,875 
                                                        ------------  ------------ 
 
 Capital and reserves 
 Share capital                                      15     3,273,617     2,110,796 
 Share premium account                              16       523,216     4,384,487 
 Retained earnings                                  17   (1,991,517)   (6,420,408) 
 Equity attributable to owners of the Company              1,805,316        74,875 
                                                        ------------  ------------ 
 
 
 
  Statement of Changes in Equity for PERIOD Ended 31 MARCH 2012 
 
 
                                                      Share                         Total 
                                        Share       premium      Retained   shareholders' 
                                      capital       account      earnings           funds 
                                          GBP           GBP           GBP             GBP 
 
 At 31 December 2009                1,490,926     3,574,640   (6,653,699)     (1,588,133) 
 
 Transactions with owners: 
  Share issue (net of costs)          619,870       809,847             -       1,429,717 
 Share based payment                        -             -        40,000          40,000 
 
  Total comprehensive income: 
  Profit for the year                       -             -       193,291         193,291 
 
 At 31 December 2010                2,110,796     4,384,487   (6,420,408)          74,875 
 
 Transactions with owners: 
  Share issue (net of costs)        1,162,821     1,822,380             -       2,985,201 
 Share based payment                        -             -        44,000          44,000 
 Capital Reduction                          -   (5,683,651)     5,683,651               - 
 
 
  Total comprehensive income: 
  Loss for the period                       -             -   (1,298,760)     (1,298,760) 
 
 
 At 31 March 2012                   3,273,617       523,216   (1,991,517)       1,805,316 
                                   ----------  ------------  ------------  -------------- 
 
 
 
 
 
 Cash Flow Statement for the PERIOD ended 31 MARCH 2012 
 
                                                         Period ended   Year ended 
                                                            31-Mar-12    31-Dec-10 
                                                                  GBP          GBP 
 
 Cash flows from operating activities: 
 
 Operating (loss)/profit                                  (1,266,341)      261,748 
 Amortisation and depreciation                                107,169       54,691 
 Share based payment expense                                   44,000       40,000 
 Increase in receivables                                    (594,444)    (292,894) 
 (Decrease)/increase in payables                                5,019    (759,576) 
 (Decrease)/increase in deferred income                     (445,203)      229,971 
 Cash used in operations                                  (2,149,800)    (466,060) 
 
 Interest paid                                               (34,856)     (69,696) 
 
 Net cash used in operating activities                    (2,184,656)    (535,756) 
 
 Cash flows from investing activities: 
 
 Interest received                                              2,437        1,239 
 Purchase of non-current assets                             (490,686)    (115,269) 
 
 Net cash used by investing activities                      (488,249)    (114,030) 
                                                        -------------  ----------- 
 
 Cash outflow before financing                            (2,672,905)    (649,786) 
 
 Cash flows from financing activities: 
 Receipt of loans                                                   -       40,865 
 Repayment of loans                                         (344,071)    (230,313) 
 Finance lease payments                                       (1,308)     (36,144) 
 Issue of ordinary share capital                            2,985,200    1,429,717 
 
 Net cash from financing activities                         2,639,821    1,204,125 
                                                        -------------  ----------- 
 
 Net (decrease)/increase in cash and cash equivalents        (33,084)      554,339 
 
 Cash and cash equivalents at beginning of year               613,339       59,000 
 
 Cash and cash equivalents at end of year                     580,255      613,339 
                                                        -------------  ----------- 
 

EARNINGS PER SHARE

The calculation of the basic and diluted earnings per share is based on the following data:

 
                                                      2012               2010 
                                                GBP                       GBP 
 Earnings: 
 (Loss)/Profit on ordinary activities 
  after tax                                    (1,298,760)            193,291 
                                             =============      ============= 
                                                       No.                No. 
 Weighted average no of shares: 
 For basic                                   2,755,785,355      2,033,232,751 
 Effect of dilutive potential ordinary 
  shares: 
  Share options                                          -         26,587,990 
 
 For diluted                                 2,755,785,355      2,059,820,741 
                                          ================   ================ 
 Basic (loss)/profit per share                    (0.047p)              0.01p 
                                          ================   ================ 
 Diluted (loss)/profit per share                  (0.047p)              0.01p 
                                          ================   ================ 
 

Notes

1. Extract from Annual Report and Accounts

The financial information set out above does not constitute the Company's statutory accounts for the periods ended 31 March 2012 or 31 December 2010 but is derived from those accounts. Statutory accounts for 2010 have been delivered to the registrar of companies, and those for 2012 will be delivered in due course. The auditors have reported on those accounts; their reports were (i) unqualified, (ii) did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying their report and (iii) did not contain a statement under section 498 (2) or (3) of the Companies Act 2006 in respect of the accounts for 2010 or 2012.The annual report and accounts for the period ended 31 March 2012 will be posted to shareholders in

June 2012. The results for the period ended 31 March 2012 were approved by the Board of Directors on 31 May 2012 and are audited. The information contained in this preliminary announcement has been approved by the Board of Directors.

2. Basis of preparation

The preliminary announcement has been prepared under the historical cost convention on a going concern basis and in accordance with the recognition and measurement principles of International Financial Reporting Standards and IFRIC interpretations as adopted by the EU ("IFRS"). The preliminary announcement has been prepared on the basis of the same accounting policies as published in the audited financial statements of the Company for the period ended 31 March 2010.

3. Report Distribution

Copies of the annual report will be sent to shareholders shortly and will be available for a period of one month to the public at the offices of Angel Biotechnology Holdings Plc, Pentlands Science Park, Penicuik, Edinburgh, UK, EH26 0PZ and at the Company's website www.angelbio.com.

This information is provided by RNS

The company news service from the London Stock Exchange

END

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