microcapbiotech
7日前
After about 30 YEARS in TPIV and MRKR,
I don't even care anymore.
Made so much $ in NVDA, MU, SNDK, CRDO, AVGO,
and many many others in the last several years buying both shares and leap call options, MRKR has become kind of irrelevant at this point.
jueles14
1月前
Classic CG / HCW analysts seeking banking business, but still:
Buy Rating Reaffirmed on Marker Therapeutics as Clinical Milestones Near; $8 Price Target Maintained
Analyst John Newman of Canaccord Genuity maintained a Buy rating on Marker Therapeutics, retaining the price target of $8.00.
John Newman’s rating is based on the view that upcoming clinical and regulatory milestones could significantly enhance Marker Therapeutics’ valuation while the risk profile remains manageable. He highlights the forthcoming APOLLO trial update in 2Q26, where additional patients and longer follow-up may confirm strong response and durability signals in a difficult, late-line non-Hodgkin’s lymphoma population, supporting confidence in MT-601’s potential.
He also points to anticipated alignment with the FDA on a pivotal, single-arm Phase 2 study in third-line DLBCL, which could provide a relatively efficient registration path. In addition, the grant-funded pancreatic cancer trial and the ongoing off-the-shelf MT-401 program in AML offer diversified upside, while the current cash runway into 1Q27 and the capacity to raise additional capital support continued development, justifying his unchanged $8 price target and Buy rating.
In another report released today, H.C. Wainwright also reiterated a Buy rating on the stock with a $10.00 price target.
microcapbiotech
2月前
Daraxonrasib Demonstrates Unprecedented Overall Survival Benefit in Pivotal Phase 3 RASolute 302 Clinical Trial in Patients with Metastatic Pancreatic Cancer.
REDWOOD CITY, Calif., April 13, 2026 (GLOBE NEWSWIRE) -- Revolution Medicines, a late-stage clinical oncology company developing targeted therapies for patients with RAS-addicted cancers, today announced positive topline results from its global, randomized, controlled Phase 3 RASolute 302 clinical trial evaluating daraxonrasib in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) who had been previously treated. Daraxonrasib taken orally once daily demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) compared with standard of care cytotoxic chemotherapy delivered intravenously. In the overall (intent-to-treat) study population, daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001). Daraxonrasib was generally well tolerated, with a manageable safety profile and with no new safety signals.Click here for full release.
learningcurve2020
4月前
>>On February 9, 2026, Marker Therapeutics, Inc. announced that its Board of Directors had set May 1, 2026 as the date for the company’s 2026 Annual Meeting of Stockholders, a move that advances the meeting more than 30 days from the prior year’s schedule and triggers specific disclosure requirements under securities regulations. As a result, the company established March 9, 2026 as the new deadline for stockholder proposals to be included in the 2026 proxy materials and directed investors to submit such proposals to its Houston corporate offices, with the record date, time and location of the meeting to be detailed in the forthcoming proxy statement.
>>On February 9, 2026, the Board of Directors of Marker Therapeutics, Inc. (the “Company”) determined it is in the best interest of the Company to schedule Company’s 2026 Annual Meeting of Stockholders (the “2026 Annual Meeting”) for May 1, 2026. Because the date of the 2026 Annual Meeting has advanced by more than 30 days from the anniversary date of the Company’s 2025 Annual Meeting of Stockholders (the “2025 Annual Meeting”), in accordance with Rule 14a-18 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the Company is informing stockholders of such change and that, accordingly, a new deadline has been set for submission of proposals by Stockholders intended to be included in the Company’s 2026 proxy statement and form of proxy. Proposals to be included in the Company’s proxy statement for the 2026 Annual Meeting in accordance with Rule 14a-8 under the Exchange Act must be received by the Company on or before March 9, 2026, which the Company believes is a reasonable time before it expects to begin to print and send its proxy materials. Stockholders must deliver the proposals or nominations to the Company’s principal executive offices at the following address: Marker Therapeutics, Inc., Attn: Corporate Secretary, 2450 Holcombe Blvd, TMC Partners Office 1.311, Houston, Texas 77021. The record date, time and location of the 2026 Annual Meeting will be as set forth in the Company’s proxy statement for the 2026 Annual Meeting.
jobynimble
5月前
Marker Therapeutics, Inc. (Nasdaq: MRKR), a clinical-stage immuno-oncology company with the worldwide exclusive license of Multi-Antigen Targeted T cells (also referred to as Multi-Antigen Recognizing T cells, or MAR-T cells, by Marker), a technology developed at Baylor College of Medicine for the treatment of hematologic and solid tumors, today announced that Baylor College of Medicine’s TACTOPS clinical study in pancreatic cancer was featured on Good Morning America on Thursday, January 22, 2026.
The segment spotlighted the Baylor-led research recently published in Nature Medicine evaluating autologous Multi-Antigen Targeted T cell therapy in patients with pancreatic ductal adenocarcinoma (PDAC) and highlighted the potential of Multi-Antigen Targeted approaches to address a significant unmet need in pancreatic cancer (Musher B et al, Nature Medicine, 2026).
“We are honored to see the Baylor pancreatic cancer study receive national attention,” said Juan Vera, M.D., President and Chief Executive Officer of Marker Therapeutics. “We congratulate Dr. Ann Leen, Dr. Benjamin Musher, and the Baylor research team on advancing this important work, and we appreciate the opportunity to help raise awareness of innovative cell therapy approaches being explored for patients facing pancreatic cancer. We believe this visibility underscores the promise of MAR-T cells and the importance of continued clinical development to improve patient outcomes.”
As previously reported, the Phase 1/2 pancreatic cancer study conducted at Baylor College of Medicine demonstrated a favorable safety profile and showed up to 84.6% disease control rate when combining Multi-Antigen Targeted T cells with frontline chemotherapy in Arm A, with the research group also highlighting a correlation between clinical benefit and the expansion and persistence of infused T cells. In Arm A, the median duration of response for patients achieving a partial or complete response was 7.5 months (range 3.5 – 16.6) and median overall survival was 14.1 months. Investigators also reported that infused T cells were detected up to 12 months post-treatment and were observed at higher frequencies in patients who responded.
Building on this encouraging Baylor clinical study, Marker seeks now to recapitulate or potentially improve upon these results in an upcoming Company-sponsored study (ClinicalTrials.gov identifier: NCT06549751) by increasing the target antigen profile, using higher cell doses and incorporating lymphodepletion to further promote T cell expansion. The Company has received funding from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) program and the Cancer Prevention and Research Institute of Texas (CPRIT) and anticipates clinical initiation of the pancreatic cancer program in the first half of 2026.
Broadcast Details
Program: Good Morning America (ABC)
Aired: Thursday, January 22, 2026
Segment Link: https://www.goodmorningamerica.com/video/129449690
About MAR-T cells
The multi-antigen recognizing (MAR) T cell platform (formerly known as multiTAA-specific T cells) is a novel, non-genetically modified cell therapy approach that selectively expands tumor-specific T cells from a patient's/donor’s blood capable of recognizing a broad range of tumor antigens. Unlike other T cell therapies, MAR-T cells allow the recognition of hundreds of different epitopes within up to six tumor-specific antigens, thereby reducing the possibility of tumor escape. Since MAR-T cells are not genetically engineered, Marker believes that its product candidates will be easier and less expensive to manufacture, with an improved safety profile compared to current engineered T cell approaches and may provide patients with meaningful clinical benefits.
About MT-601
The Company’s lead product, MT-601, is a multi-antigen recognizing (MAR) T cell product that utilizes a non-genetically modified approach that specifically targets six different tumor antigens upregulated in tumor cells (Survivin, PRAME, WT-1, NY-ESO-1, SSX-2, MAGEA-4). Marker is currently investigating MT-601 in the Phase 1 APOLLO trial (clinicaltrials.gov identifier: NCT05798897) for the treatment of patients with lymphoma who have relapsed after or are ineligible to receive anti-CD19 CAR-T cell therapies. Due to the broad target recognition profile of MT-601, the Company is exploring its potential application beyond lymphoma in patients with pancreatic cancer. The Company’s pancreatic cancer program is supported by the National Cancer Institute of the National Institutes of Health (Award Number R44CA295168), and the Cancer Prevention and Research Institute of Texas (CPRIT, Award Number DP250150).
About Marker Therapeutics, Inc.
Marker Therapeutics, Inc. is a Houston, TX-based clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumors. The Company was founded at Baylor College of Medicine, and clinical trials that enrolled more than 200 patients across various hematological and solid tumor indications showed that the Company’s autologous and allogeneic MAR-T cell products were well tolerated and demonstrated durable clinical responses. Marker’s goal is to introduce novel T cell therapies to the market and improve patient outcomes. To achieve these objectives, the Company prioritizes the preservation of financial resources and focuses on operational excellence. Marker’s unique T cell platform is strengthened by non-dilutive funding from U.S. state and federal agencies supporting cancer research.
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