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UNITED STATES
SECURITIES AND EXCHANGE
COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13
OR 15(d)
OF THE SECURITIES EXCHANGE
ACT OF 1934
Date of Report (Date of earliest
event reported):
June 11, 2024
60 DEGREES PHARMACEUTICALS,
INC.
(Exact name of registrant
as specified in its charter)
Delaware |
|
001-41719 |
|
45-2406880 |
(State or other jurisdiction
of Incorporation) |
|
(Commission File Number) |
|
(IRS Employer
Identification Number) |
1025 Connecticut Avenue NW Suite 1000,
Washington, D.C. |
|
20036 |
(Address of registrant’s principal executive office) |
|
(Zip code) |
(202) 327-5422
(Registrant’s telephone
number, including area code)
Not Applicable
(Former name or former address,
if changed since last report)
Check the appropriate box
below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following
provisions (see General Instruction A.2. below):
☐ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
☐ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
☐ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
☐ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant
to Section 12(b) of the Act:
Title of each class |
|
Trading symbol(s) |
|
Name of each exchange on which
registered |
Common Stock, par value $0.0001 per share |
|
SXTP |
|
The Nasdaq Stock Market LLC |
Warrants, each warrant to purchase one share of Common Stock |
|
SXTPW |
|
The Nasdaq Stock Market LLC |
Indicate by check mark whether
the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule
12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging
growth company ☒
If an emerging growth company,
indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act.
Item 8.01. Other Events.
On June 11, 2024, 60 Degrees
Pharmaceuticals, Inc. (the “Company”) issued a press release announcing that the Company received U.S. Food and Drug Administration
orphan drug designation for tafenoquine for treatment of patients with acute babesiosis. The
Company’s press release is filed as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
The information set forth
under this Item 8.01, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities
Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall
it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly
set forth by specific reference in such a filing.
Item 9.01 Financial Statements
and Exhibits.
(d) Exhibits.
The following exhibits are
being filed herewith:
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.
|
60 DEGREES PHARMACEUTICALS, INC. |
|
|
Date: June 12, 2024 |
By: |
/s/ Geoffrey Dow |
|
Name: |
Geoffrey Dow |
|
Title: |
Chief Executive Officer and President |
Exhibit 99.1
60 Degrees Pharmaceuticals Receives
FDA Orphan Drug Designation for Tafenoquine for Treatment of Patients with Acute Babesiosis
| · | With
the tafenoquine for acute babesiosis orphan drug designation, 60 Degrees Pharmaceuticals
now qualifies for certain incentives, including market exclusivity, tax credits, and exemption
from certain FDA filing fees. |
| · | 60
Degrees Pharmaceuticals recently announced it has entered into an agreement with Tufts
Medical Center in Boston to
conduct the world’s first clinical trial evaluating the efficacy and safety
of tafenoquine in
treating human babesiosis patients. |
| · | FDA
orphan drug designation is granted for therapeutic candidates that may prevent or treat a
rare disease or condition, such as acute babesiosis. |
WASHINGTON, June 11, 2024 (GLOBE NEWSWIRE)
-- 60 Degrees Pharmaceuticals, Inc. (NASDAQ: SXTP; SXTPW) (the “Company” or “60 Degrees Pharmaceuticals”), a
pharmaceutical company focused on developing new medicines for infectious diseases, announced today that the U.S. Food and Drug Administration
(“FDA”) has granted its investigational tafenoquine candidate orphan drug designation for the treatment of patients
with acute babesiosis.
FDA orphan drug designation is granted
for therapeutic candidates that may prevent or treat a rare disease or condition, such as acute babesiosis. Babesiosis is a steadily
emerging, infectious disease transmitted by a microscopic parasite, Babesia, through the bite of the black-legged (deer) tick,
the vector that spreads Lyme disease. Babesiosis may be life-threatening in elderly and immunosuppressed patients. Up to 10 percent of
Lyme disease patients may be coinfected with Babesia. Therefore, up to 47,600 of the estimated 476,000 patients with new Lyme infections
each year may be co-infected with Babesia.
“Results of recent animal studies
of tafenoquine show exciting promise for the drug to have potential in human patients with acute babesiosis,” said Chief
Executive Officer of 60 Degrees Pharmaceuticals, Geoff Dow, PhD. “The FDA granting tafenoquine orphan drug designation for
acute babesiosis validates the growing need for an additional therapeutic option that infectious disease specialists can use in addressing
this very serious, potentially life-threatening illness. We look forward to results of our clinical trial program in coming months and
to the prospect of securing a secondary indication for tafenoquine in the area of acute babesiosis treatment.”
60 Degrees Pharmaceuticals
recently announced it has entered into an agreement with Tufts Medical Center in Boston to
conduct the world’s first clinical trial evaluating the efficacy and safety of tafenoquine in
treating patients who have acute babesiosis. Recruitment for the trial will begin on June 13, 2024, and will include at least
24 patients hospitalized with babesiosis. Additional recruitment sites at prominent university hospitals in the Northeast U.S. are also
planned.
With the tafenoquine for acute babesiosis
orphan drug designation, 60 Degrees Pharmaceuticals now qualifies for certain incentives, including market exclusivity, tax credits,
and exemption from certain FDA filing fees.
About Tafenoquine
Tafenoquine is
approved for malaria prophylaxis in the United States under
the product name ARAKODA®. The safety of the approved regimen of tafenoquine for
malaria prophylaxis has been assessed in five separate randomized, double-blind, active comparator or placebo-controlled trials for durations
of up to six months. Tafenoquine has not been proven
to be effective for treatment or prevention of babesiosis and is not approved by the U.S. Food and Drug Administration for
such an indication.
About the Study of Tafenoquine for Patients
Hospitalized with Babesiosis
The study is a randomized, double-blind,
placebo-controlled trial that will enroll patients at multiple sites in the Northeast U.S. and will compare the safety and
efficacy of tafenoquine versus placebo in patients hospitalized for babesiosis with low risk for relapsing disease who will also
be administered a standard-of-care antimicrobial regimen. The two main study endpoints will be the time to sustained clinical resolution
of symptoms and the time to molecular cure as determined by an FDA-approved nucleic acid test. At least 24, and as many as 33 patients,
will be recruited before an interim analysis is conducted. Sufficient enrollment capacity is planned to allow all study subjects to be
recruited during the 2024 tick season (June to September) if caseload is high. The interim analysis will include both a test of significance,
as well as size re-estimation to allow additional recruitment if required. The study will be conducted at three hospitals in the Northeast
U.S. The efficacy and safety of 8-aminoquinolines, a class of drugs that includes tafenoquine and primaquine, for
prevention and treatment of malaria is well documented. Several case reports of tafenoquine use for babesiosis indicate
that the drug is already being used for this purpose in the practice of medicine in the U.S.
About
ARAKODA® (tafenoquine)
Tafenoquine was discovered by Walter Reed Army Institute of Research. Tafenoquine was approved for malaria
prophylaxis in 2018 in the United States as ARAKODA® and in Australia as KODATEF®.
Both were commercially launched in 2019 and are currently distributed through pharmaceutical wholesaler networks in each respective country.
They are available at retail pharmacies as a prescription-only malaria prevention drug. According to the Centers for Disease Control
and Prevention, the long terminal half-life of tafenoquine, which is approximately 16 days, may offer potential advantages
in less-frequent dosing for prophylaxis for malaria. ARAKODA® is not suitable for everyone, and patients and prescribers
should review the Important Safety Information below. Individuals at risk of contracting malaria are prescribed ARAKODA®
2 x 100 mg tablets once per day for three days (the loading phase) prior to travel to an area of the world where malaria is endemic,
2 x 100 mg tablets weekly for up to six months during travel, then 2 x 100 mg in the week following travel.
ARAKODA® (tafenoquine)
Important Safety Information
ARAKODA® is an antimalarial indicated for the prophylaxis of malaria in patients aged 18 years of age and older.
Contraindications
ARAKODA® should not be administered to:
|
· |
Glucose-6-phosphate dehydrogenase (“G6PD”) deficiency or unknown G6PD status; |
|
· |
Breastfeeding by a lactating woman when the infant is found to be G6PD deficient; or if |
|
· |
G6PD status is unknown; |
|
· |
Patients with a history of psychotic disorders or current psychotic symptoms; or |
|
· |
Known hypersensitivity reactions to tafenoquine, other 8-aminoquinolines, or any component of ARAKODA(R). |
Warnings
and Precautions
Hemolytic Anemia: G6PD testing must be performed before prescribing ARAKODA® due to the risk of hemolytic
anemia. Monitor patients for signs or symptoms of hemolysis.
G6PD Deficiency in Pregnancy or Lactation: ARAKODA® may cause fetal harm when administered to a pregnant woman with
a G6PD-deficient fetus. ARAKODA® is not recommended during pregnancy. A G6PD-deficient infant may be at risk for hemolytic
anemia from exposure to ARAKODA® through breast milk. Check infant’s G6PD status before breastfeeding begins.
Methemoglobinemia: Asymptomatic elevations in blood methemoglobin have been observed. Initiate appropriate therapy if signs
or symptoms of methemoglobinemia occur.
Psychiatric Effects: Serious psychotic adverse reactions have been observed in patients with a history of psychosis or schizophrenia,
at doses different from the approved dose. If psychotic symptoms (hallucinations, delusions, or grossly disorganized thinking or behavior)
occur, consider discontinuation of ARAKODA® therapy and evaluation by a mental health professional as soon as possible.
Hypersensitivity Reactions: Serious hypersensitivity reactions have been observed with administration of ARAKODA®.
If hypersensitivity reactions occur, institute appropriate therapy.
Delayed Adverse Reactions: Due to the long half-life of ARAKODA® (approximately 16 days), psychiatric effects,
hemolytic anemia, methemoglobinemia, and hypersensitivity reactions may be delayed in onset and/or duration.
Adverse Reactions: The most common adverse reactions (incidence greater than or equal to 1 percent) were: headache, dizziness,
back pain, diarrhea, nausea, vomiting, increased alanine aminotransferase, motion sickness, insomnia, depression, abnormal dreams, and
anxiety.
Drug Interactions
Avoid co-administration with drugs that are substrates of organic cation transporter-2 or multidrug and toxin extrusion transporters.
Use
in Specific Populations
Lactation: Advise women not to breastfeed a G6PD-deficient infant or infant with unknown G6PD status during treatment and for 3 months
after the last dose of ARAKODA®.
To report SUSPECTED ADVERSE REACTIONS, contact 60 Degrees Pharmaceuticals, Inc. at 1- 888-834-0225 or the FDA at 1-800-FDA-1088
or www.fda.gov/medwatch. The full prescribing information of ARAKODA® is located here.
About 60 Degrees Pharmaceuticals,
Inc.
60 Degrees Pharmaceuticals, Inc., founded in 2010, specializes in developing and marketing new medicines for the treatment and prevention
of infectious diseases that affect the lives of millions of people. 60 Degrees Pharmaceuticals, Inc. achieved FDA approval
of its lead product, ARAKODA® (tafenoquine), for malaria prevention, in 2018. 60 Degrees Pharmaceuticals,
Inc. also collaborates with prominent research organizations in the U.S., Australia, and Singapore. The 60 Degrees
Pharmaceuticals, Inc. mission has been supported through in-kind funding from the U.S. Department of Defense and private
institutional investors including Knight Therapeutics Inc., a Canadian-based pan-American specialty pharmaceutical company. 60 Degrees
Pharmaceuticals, Inc. is headquartered in Washington D.C., with a majority-owned subsidiary in Australia. Learn more at www.60degreespharma.com.
The statements contained herein may include
prospects, statements of future expectations and other forward-looking statements that are based on management’s current views
and assumptions and involve known and unknown risks and uncertainties. Actual results, performance or events may differ materially from
those expressed or implied in such forward-looking statements.
Cautionary Note Regarding Forward-Looking
Statements
This press release may contain “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private
Securities Litigation Reform Act of 1995. Forward-looking statements reflect the current view about future events. When used in this
press release, the words “anticipate,” “believe,” “estimate,” “expect,” “future,”
“intend,” “plan,” or the negative of these terms and similar expressions, as they relate to us or our management,
identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead,
they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans
and strategies, projections, anticipated events and trends, the economy, activities of regulators and future regulations and other future
conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in
circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition
may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking
statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in
the forward-looking statements include, among others, the following: there is substantial doubt as to our ability to continue on a going-concern
basis; we might not be eligible for Australian government research and development tax rebates; if we are not able to successfully develop,
obtain FDA approval for, and provide for the commercialization of non- malaria prevention indications for tafenoquine (ARAKODA® or
other regimen) or Celgosivir in a timely manner, we may not be able to expand our business operations; we may not be able to successfully
conduct planned clinical trials or patient recruitment in our trials might be slow or negligible; and we have no manufacturing capacity
which puts us at risk of lengthy and costly delays of bringing our products to market. More detailed information about the Company
and the risk factors that may affect the realization of forward-looking statements is set forth in the Company’s filings with the Securities
and Exchange Commission (“SEC”), including the information contained in our Annual Report on Form 10-K filed with the SEC on April
1, 2024, and our subsequent SEC filings. Investors and security holders are urged to read these documents free of charge on
the SEC’s web site at www.sec.gov. As a result of these matters, changes in facts, assumptions not being realized or other
circumstances, the Company’s actual results may differ materially from the expected results discussed in the forward-looking statements
contained in this press release. Any forward-looking statement made by us in this press release is based only on information currently
available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking
statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or
otherwise.
Media Contact:
Sheila A. Burke
SheilaBurke-consultant@60degreespharma.com
(484) 667-6330
Investor Contact:
Patrick Gaynes
patrickgaynes@60degreespharma.com
(310) 989-5666
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60 Degrees Pharmaceuticals (NASDAQ:SXTPW)
過去 株価チャート
から 5 2024 まで 6 2024
60 Degrees Pharmaceuticals (NASDAQ:SXTPW)
過去 株価チャート
から 6 2023 まで 6 2024