[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
Washington, D.C. 20549
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
1. Name and Address of Reporting Person * Dolsten Mikael 2. Issuer Name and Ticker or Trading Symbol PFIZER INC [ PFE ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
President R&D
(Last)          (First)          (Middle)
3. Date of Earliest Transaction (MM/DD/YYYY)
NEW YORK, NY 10017
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  5/11/2022    S    200.0000  D $49.3600  397044.0000  D   
Common Stock  5/11/2022    S    2358.0000  D $49.3400  394686.0000  D   
Common Stock  5/11/2022    S    2891.0000  D $49.3500  391795.0000  D   
Common Stock  5/11/2022    S    7876.0000  D $49.3300  383919.0000  D   
Common Stock  5/11/2022    S    18562.0000  D $49.3200  365357.0000  D   
Common Stock  5/11/2022    S    32015.0000  D $49.3100  333342.0000  D   
Common Stock                 1817.0000  I  By Rule 16b-3 Plan 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Phantom Stock Units SSP   (1) 5/11/2022    I     15167.0000 (2)      (3)  (3) Common Stock  15167.0000  $49.4500  27380.0000  D   

Explanation of Responses:
(1)  Each unit represents one phantom share of common stock.
(2)  This transaction constitutes an intra-plan transfer into the Pfizer stock unit fund under the Pfizer Inc. Supplemental Savings Plan.
(3)  These units, which were acquired pursuant to the Pfizer Supplemental Savings Plan, are settled in cash following the reporting person's separation from service and may be transferred by the reporting person into an alternative investment account at any time.

Reporting Owners
Reporting Owner Name / Address
Director 10% Owner Officer Other
Dolsten Mikael
235 EAST 42ND ST.
NEW YORK, NY 10017

President R&D

Susan E. Grant, by power of atty., for Mikael Dolsten 5/12/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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