FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * McDermott Michael 2. Date of Event Requiring Statement (MM/DD/YYYY)
1/1/2022 

3. Issuer Name and Ticker or Trading Symbol PFIZER INC [PFE]
(Last)       (First)       (Middle)
PFIZER INC.-CORP. SECRETARY, 235 EAST 42ND ST.
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Executive Vice President /
(Street)
NEW YORK, NY 10017      
(City)             (State)             (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock  66186.0000  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Appreciation Rights  2/25/2023 (1) 2/25/2023 (1) Common Stock  14178.0000  $22.8900  D   
Stock Appreciation Rights  2/26/2022 (1) 2/26/2022 (1) Common Stock  12340.0000  $25.6000  D   
Stock Appreciation Rights  2/23/2022 (2) 2/23/2022 (2) Common Stock  14952.0000  $27.3400  D   
Stock Appreciation Rights  2/23/2024 (1) 2/23/2024 (1) Common Stock  12412.0000  $27.3400  D   
Stock Appreciation Rights  2/22/2023 (2) 2/22/2023 (2) Common Stock  13307.0000  $30.1700  D   
Stock Appreciation Rights  2/22/2025 (1) 2/22/2025 (1) Common Stock  11125.0000  $30.1700  D   
Stock Appreciation Rights  2/27/2025 (2) 2/27/2025 (2) Common Stock  48419.0000  $31.3100  D   
Stock Appreciation Rights  2/27/2027 (1) 2/27/2027 (1) Common Stock  41485.0000  $31.3100  D   
Stock Appreciation Rights  2/25/2026 (2) 2/25/2026 (2) Common Stock  37925.0000  $33.8200  D   
Stock Appreciation Rights  2/25/2028 (1) 2/25/2028 (1) Common Stock  32769.0000  $33.8200  D   
Stock Appreciation Rights  2/28/2024 (2) 2/28/2024 (2) Common Stock  18999.0000  $38.7100  D   
Stock Appreciation Rights  2/28/2026 (1) 2/28/2026 (1) Common Stock  16011.0000  $38.7100  D   

Explanation of Responses:
(1)  The stock appreciation rights, which are subject to certain vesting requirements, will be settled in shares of Pfizer common stock on the seventh anniversary of the date of grant.
(2)  The stock appreciation rights, which are subject to certain vesting requirements, will be settled in shares of Pfizer common stock on the fifth anniversary of the date of grant.

Remarks:
poamm21.htm

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
McDermott Michael
PFIZER INC.-CORP. SECRETARY
235 EAST 42ND ST.
NEW YORK, NY 10017


Executive Vice President

Signatures
Susan E. Grant, by power of atty., for Michael McDermott 1/10/2022
**Signature of Reporting Person Date
Pfizer (NYSE:PFE)
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Pfizer (NYSE:PFE)
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